Pub Date : 2017-11-08DOI: 10.4172/2324-8777.1000233
Adem Beriso
Until now cancer detection and treatment methods are mostly ineffective due to the following two main reasons. Firstly, patients go to health center when they feel ill, most probably after cancer cells created in their body some long time later and/or the methods by themselves are non-specific screening methods, which often resulted in late cancer detection for effective treatment and some of these methods may be destructive to normal cells or even can cause cancer. Secondly, current cancer treatment methods are non-selection and toxic those kill both abnormal and normal cells leading to serious side effects. The use of nanotechnology to health sector, particularly its ability to detect cancer in its early stage and for complete treatment along with reducing toxicity, promises to have a deep impact on healthcare in general and on cancer in particular. This new technology has already shown the potential to detect cancer in its early stage and to increase the specificity of treatment of tumor cells while leaving healthy cells undamaged through the use of the unique properties of nanoparticles. This review discusses the use of nanoparticles such as quantum dots, magnetic nanoparticles, gold nanoparticles, polymeric micelles, liposomes, dendrimers and porous silicon nanoparticles for the early detection and treatment of cancer.
{"title":"Early Cancer Detection and Treatment with Nanotechnology","authors":"Adem Beriso","doi":"10.4172/2324-8777.1000233","DOIUrl":"https://doi.org/10.4172/2324-8777.1000233","url":null,"abstract":"Until now cancer detection and treatment methods are mostly ineffective due to the following two main reasons. Firstly, patients go to health center when they feel ill, most probably after cancer cells created in their body some long time later and/or the methods by themselves are non-specific screening methods, which often resulted in late cancer detection for effective treatment and some of these methods may be destructive to normal cells or even can cause cancer. Secondly, current cancer treatment methods are non-selection and toxic those kill both abnormal and normal cells leading to serious side effects. The use of nanotechnology to health sector, particularly its ability to detect cancer in its early stage and for complete treatment along with reducing toxicity, promises to have a deep impact on healthcare in general and on cancer in particular. This new technology has already shown the potential to detect cancer in its early stage and to increase the specificity of treatment of tumor cells while leaving healthy cells undamaged through the use of the unique properties of nanoparticles. This review discusses the use of nanoparticles such as quantum dots, magnetic nanoparticles, gold nanoparticles, polymeric micelles, liposomes, dendrimers and porous silicon nanoparticles for the early detection and treatment of cancer.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"44 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73762951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-06DOI: 10.4172/2324-8777.1000228
S. Arumugam
Two types of multi-walled carbon nanotubes are (MWCNTs) functionalized with dendrimer/palladium nanoparticle catalysts viz., MWCNTs-poly(propylene imine) generation 2 (G2)-PdNPs (MWCNTs-PPI(G2)-PdNPs) and MWCNTs-poly(propylene imine) generation 3 (G3)-PdNPs (MWCNTs-PPI(G3)-PdNPs) were prepared. The newly developed catalysts were characterized by the spectroscopic/microscopic techniques. The catalytic activity of these catalysts were investigated by performing C-C cross coupling reactions viz., (i) Suzuki-Miyaura, (ii) Heck and (iii) Sonogashira as model reactions. The formation of product in each reaction was identified by thin layer chromatographic (TLC) technique (2:8 percentages of ethyl acetate and hexane) and then purified by column chromatography.The resulting products were characterized by 1H and 13CNMR spectroscopy and the percentage of yield was calculated by gravimetrical method. The study of reusability of the superior catalyst viz.,MWCNT-PPI(G3)-PdNPs was examined so as to know the stability of the catalyst for the same reactions.
用树状聚合物/钯纳米颗粒催化剂对两种多壁碳纳米管(MWCNTs)进行功能化，分别制备了MWCNTs-聚丙烯亚胺第2代(G2)-PdNPs (MWCNTs- ppi (G2)-PdNPs)和MWCNTs-聚丙烯亚胺第3代(G3)-PdNPs (MWCNTs- ppi (G3)-PdNPs)。采用光谱学/显微技术对催化剂进行了表征。通过(i) Suzuki-Miyaura， (ii) Heck和(iii) Sonogashira交叉偶联反应考察了这些催化剂的催化活性。采用薄层色谱(TLC)技术鉴定各反应产物的形成(乙酸乙酯和己烷的比例为2:8)，然后采用柱层析纯化。用1H和13CNMR光谱对产物进行了表征，并用重量法计算了产率。考察了优选催化剂MWCNT-PPI(G3)-PdNPs的可重复使用性，以了解催化剂在相同反应中的稳定性。
{"title":"New Multi-Walled Carbon Nanotubes Functionalized with Dendrimer Stabilized Palladium Nanoparticles Catalyst for C-C Cross Coupling Reactions","authors":"S. Arumugam","doi":"10.4172/2324-8777.1000228","DOIUrl":"https://doi.org/10.4172/2324-8777.1000228","url":null,"abstract":"Two types of multi-walled carbon nanotubes are (MWCNTs) functionalized with dendrimer/palladium nanoparticle catalysts viz., MWCNTs-poly(propylene imine) generation 2 (G2)-PdNPs (MWCNTs-PPI(G2)-PdNPs) and MWCNTs-poly(propylene imine) generation 3 (G3)-PdNPs (MWCNTs-PPI(G3)-PdNPs) were prepared. The newly developed catalysts were characterized by the spectroscopic/microscopic techniques. The catalytic activity of these catalysts were investigated by performing C-C cross coupling reactions viz., (i) Suzuki-Miyaura, (ii) Heck and (iii) Sonogashira as model reactions. The formation of product in each reaction was identified by thin layer chromatographic (TLC) technique (2:8 percentages of ethyl acetate and hexane) and then purified by column chromatography.The resulting products were characterized by 1H and 13CNMR spectroscopy and the percentage of yield was calculated by gravimetrical method. The study of reusability of the superior catalyst viz.,MWCNT-PPI(G3)-PdNPs was examined so as to know the stability of the catalyst for the same reactions.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"33 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91204101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-06DOI: 10.4172/2324-8777.1000230
B. T. Usubaliev, Tagiyev Db, Nurullayev Vh, Munshieva Mk, Aliyeva Fb, Hasanova Mm, Rzayeva Aq, Safarova Ps
The coordination compounds of iron (II) and (III) with phthalic acid were synthesized. The compounds were studied by X-ray diffraction (XRD), differential thermal (DTA), and IR spectroscopy. It has been established that, regardless of the oxidative number of iron, the synthesis products have the same chemical composition and chemical formula - [Fe2(o-C6H4(COO)2)3]. It also found that the carboxyl groups of phthalate dianion have a monodentate and bridging function, and the complex itself is a polymer-layered structure. Based on the obtained results, given the proposed schematic structure of the complex compound. Also were studied the thermal stability of the complex compound in the temperature range 20-660°С and the supramolecular interaction of this substance with the rheological properties of heavy commercial oils.
{"title":"Synthesis and Physico-Chemical Studies of Complex Compounds of Iron (II) and (III) With Phthalic Acid","authors":"B. T. Usubaliev, Tagiyev Db, Nurullayev Vh, Munshieva Mk, Aliyeva Fb, Hasanova Mm, Rzayeva Aq, Safarova Ps","doi":"10.4172/2324-8777.1000230","DOIUrl":"https://doi.org/10.4172/2324-8777.1000230","url":null,"abstract":"The coordination compounds of iron (II) and (III) with phthalic acid were synthesized. The compounds were studied by X-ray diffraction (XRD), differential thermal (DTA), and IR spectroscopy. It has been established that, regardless of the oxidative number of iron, the synthesis products have the same chemical composition and chemical formula - [Fe2(o-C6H4(COO)2)3]. It also found that the carboxyl groups of phthalate dianion have a monodentate and bridging function, and the complex itself is a polymer-layered structure. Based on the obtained results, given the proposed schematic structure of the complex compound. Also were studied the thermal stability of the complex compound in the temperature range 20-660°С and the supramolecular interaction of this substance with the rheological properties of heavy commercial oils.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"39 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73235955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-06DOI: 10.4172/2324-8777.1000231
Elaheh Mohebbi
The adsorption of ethylene and acetylene molecules on Ag (110) surface has been investigated by using density-functional theory with and without consideration of dispersion (van der Waals interactions) between molecules and the surface. We find that both molecules prefer to adsorb on atop site of the step edge in comparison to the short bridge, long bridge and hollow sites. Our results indicate the weak interaction between adsorbates and substrate and the molecular geometry are almost unaffected by adsorption. The new results including dispersion in our calculations for the most stable site (atop) of ethylene and acetylene molecules on Ag (110) surface; show a good agreement with experimental adsorption energy especially for acetylene.
{"title":"Adsorption of Ethylene and Acetylene Molecules on Ag (110) Surface","authors":"Elaheh Mohebbi","doi":"10.4172/2324-8777.1000231","DOIUrl":"https://doi.org/10.4172/2324-8777.1000231","url":null,"abstract":"The adsorption of ethylene and acetylene molecules on Ag (110) surface has been investigated by using density-functional theory with and without consideration of dispersion (van der Waals interactions) between molecules and the surface. We find that both molecules prefer to adsorb on atop site of the step edge in comparison to the short bridge, long bridge and hollow sites. Our results indicate the weak interaction between adsorbates and substrate and the molecular geometry are almost unaffected by adsorption. The new results including dispersion in our calculations for the most stable site (atop) of ethylene and acetylene molecules on Ag (110) surface; show a good agreement with experimental adsorption energy especially for acetylene.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"69 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82664825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-06DOI: 10.4172/2324-8777.1000229
Y. Taranets, O. Bezkrovnaya, I. Pritula, P. Mateychenko
Investigated is the effect of L-threonine (L-thr) amino acid on the growth of pathogenic calcium oxalate monohydrate (СОМ) crystals. It is found that L-thr molecules inhibit the growth of COM crystals and prevent their aggregation. Additions of 2-4 mM L-threonine in the investigated system decreases the crystal size (5-6 μm) in comparison with that of СОМ crystals without additives (9 μm). Increase of L-thr concentration in the solution up to 8-20 mM does not lead to further decrease of the crystal size.
研究了l -苏氨酸(L-thr)氨基酸对致病性一水草酸钙(СОМ)晶体生长的影响。发现L-thr分子抑制COM晶体的生长并阻止其聚集。与未添加l -苏氨酸(9 μm)的СОМ相比，添加2-4 mM l -苏氨酸使晶体尺寸减小(5-6 μm)。当溶液中L-thr浓度增加到8 ~ 20 mM时，晶体尺寸不会进一步减小。
{"title":"L-Threonine Amino Acid as a Promoter of the Growth of Pathogenic Calcium Oxalate Monohydrate Crystals","authors":"Y. Taranets, O. Bezkrovnaya, I. Pritula, P. Mateychenko","doi":"10.4172/2324-8777.1000229","DOIUrl":"https://doi.org/10.4172/2324-8777.1000229","url":null,"abstract":"Investigated is the effect of L-threonine (L-thr) amino acid on the growth of pathogenic calcium oxalate monohydrate (СОМ) crystals. It is found that L-thr molecules inhibit the growth of COM crystals and prevent their aggregation. Additions of 2-4 mM L-threonine in the investigated system decreases the crystal size (5-6 μm) in comparison with that of СОМ crystals without additives (9 μm). Increase of L-thr concentration in the solution up to 8-20 mM does not lead to further decrease of the crystal size.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"65 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84367894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-06DOI: 10.4172/2324-8777.1000232
Dilan S. Udawattha, Kasthurige Se, M. Narayana
Nano fluids consist of thermal conductivity enhancement compared to the base fluid, but the cost of synthesizing of nanoparticles hinders its industrial applications. Recently, it was found that graphene nanolayers can be obtained by shear exfoliation of liquids. Moreover, graphene synthesizes by relatively abandon material graphite. In contrast to conventional heat transfer liquid like water, nanofluids are not transparent to solar thermal applications. It has been proven beyond doubt that kerosene, diesel and gasoline based nanofluids heat transfer coefficient enhancement would improve their efficiency of applications. In this paper water, kerosene, gasoline and diesel based nanofluids containing graphene nanolayers were prepared by shear exfoliation of fluids. Presents of graphene nanolayers were confirmed by scanning electron microscopic images. A spectrophotometer used to measure the stability of water, kerosene, gasoline and diesel nanofluids. Absorption of water-graphene nanofluid was examined to analyze the effectiveness of water based nanofluid for the solar collectors.
{"title":"Graphene in the Form of Liquid Suspension by Shear Exfoliation of Liquids: Stability Study of Gasoline, Diesel, Kerosene and Water Based Nanofluids Containing Graphene Nanolayers","authors":"Dilan S. Udawattha, Kasthurige Se, M. Narayana","doi":"10.4172/2324-8777.1000232","DOIUrl":"https://doi.org/10.4172/2324-8777.1000232","url":null,"abstract":"Nano fluids consist of thermal conductivity enhancement compared to the base fluid, but the cost of synthesizing of nanoparticles hinders its industrial applications. Recently, it was found that graphene nanolayers can be obtained by shear exfoliation of liquids. Moreover, graphene synthesizes by relatively abandon material graphite. In contrast to conventional heat transfer liquid like water, nanofluids are not transparent to solar thermal applications. It has been proven beyond doubt that kerosene, diesel and gasoline based nanofluids heat transfer coefficient enhancement would improve their efficiency of applications. In this paper water, kerosene, gasoline and diesel based nanofluids containing graphene nanolayers were prepared by shear exfoliation of fluids. Presents of graphene nanolayers were confirmed by scanning electron microscopic images. A spectrophotometer used to measure the stability of water, kerosene, gasoline and diesel nanofluids. Absorption of water-graphene nanofluid was examined to analyze the effectiveness of water based nanofluid for the solar collectors.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"12 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89949066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-22DOI: 10.4172/2324-8777.1000225
Ş. Çolak, Cangül Aktürk
In the present study, undoped ZnO and Mn, Cu and Co doped (5 mol%) ZnO nanoparticles have been synthesized by hydrosis method and structural, optical, magnetic properties of these samples have been performed. Crystal sizes of the undoped and doped ZnO nanoparticles have been determined to be ∼12 nm by XRD analysis. The crystallite size of ZnO nanoparticles have been observed to be decreased by doping process. A single, broad and unresolved EPR signal with additional two resonance peaks, Ia and Ib which are believed to be related with oxygen and zinc damage centers, and have been arised for the undoped ZnO nanoparticles. Six resolved, four resolved and a single unresolved EPR resonance signals were also recorded for the Mn, Cu and Co doped ZnO nanoparticles, respectively. UV irradiation caused some organoleptic changes for undoped and doped ZnO nanoparticles. Also, some new EPR resonance lines have also been arised for UV-irradiated ZnO nanoparticles which were accepted to be originating from the formation of oxygen and/or zinc damage centers during the UVirradiation process. From UV-Vis studies, the absorbance peaks for the synthesized ZnO nanoparticles have been appeared at ∼360 nm and the mean gap energy was calculated to be 3.20-3.32 eV. The band gap enery of undoped ZnO have found to be decreased by doping process.
{"title":"Investigation of Synthesized ZnO Nanoparticles","authors":"Ş. Çolak, Cangül Aktürk","doi":"10.4172/2324-8777.1000225","DOIUrl":"https://doi.org/10.4172/2324-8777.1000225","url":null,"abstract":"In the present study, undoped ZnO and Mn, Cu and Co doped (5 mol%) ZnO nanoparticles have been synthesized by hydrosis method and structural, optical, magnetic properties of these samples have been performed. Crystal sizes of the undoped and doped ZnO nanoparticles have been determined to be ∼12 nm by XRD analysis. The crystallite size of ZnO nanoparticles have been observed to be decreased by doping process. A single, broad and unresolved EPR signal with additional two resonance peaks, Ia and Ib which are believed to be related with oxygen and zinc damage centers, and have been arised for the undoped ZnO nanoparticles. Six resolved, four resolved and a single unresolved EPR resonance signals were also recorded for the Mn, Cu and Co doped ZnO nanoparticles, respectively. UV irradiation caused some organoleptic changes for undoped and doped ZnO nanoparticles. Also, some new EPR resonance lines have also been arised for UV-irradiated ZnO nanoparticles which were accepted to be originating from the formation of oxygen and/or zinc damage centers during the UVirradiation process. From UV-Vis studies, the absorbance peaks for the synthesized ZnO nanoparticles have been appeared at ∼360 nm and the mean gap energy was calculated to be 3.20-3.32 eV. The band gap enery of undoped ZnO have found to be decreased by doping process.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"29 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88965859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-22DOI: 10.4172/2324-8777.1000224
H. R. Taghiyari, Vahid Hassani, S. Maleki, C. Eckelman
The effect of changes of urea-formaldehyde resin content and nanowollastonite content on the withdrawal capacities of sheet metal screws and medium density fiberboard screws from the edge, face, and end surfaces of oriented strand lumber were investigated. The panels were produced with two urea-formaldehyde resin contents (8% and 10%), and two nano-wollastonite contents (10% and 20%). Specimens were prepared and tested according to ASTM standard D 1761-88. Sheet metal screws had a higher withdrawal capacity than medium density fiberboard screws. Withdrawal capacity in the face and edge directions were significantly higher than in the end direction. Changes in urea-formaldehyde resin content had no effect on screw withdrawal capacity in any of the three directions, implying that compaction in the composite panels had higher impact on screw withdrawal strength in comparison to the increase in resincontent from 8% to 10%. However, addition of NW resulted in a decrease in withdrawal capacity values at both resin levels in all directions.
{"title":"Effects of Nano-Wollastonite on Screw Withdrawal Capacity of Oriented Strand Lumber","authors":"H. R. Taghiyari, Vahid Hassani, S. Maleki, C. Eckelman","doi":"10.4172/2324-8777.1000224","DOIUrl":"https://doi.org/10.4172/2324-8777.1000224","url":null,"abstract":"The effect of changes of urea-formaldehyde resin content and nanowollastonite content on the withdrawal capacities of sheet metal screws and medium density fiberboard screws from the edge, face, and end surfaces of oriented strand lumber were investigated. The panels were produced with two urea-formaldehyde resin contents (8% and 10%), and two nano-wollastonite contents (10% and 20%). Specimens were prepared and tested according to ASTM standard D 1761-88. Sheet metal screws had a higher withdrawal capacity than medium density fiberboard screws. Withdrawal capacity in the face and edge directions were significantly higher than in the end direction. Changes in urea-formaldehyde resin content had no effect on screw withdrawal capacity in any of the three directions, implying that compaction in the composite panels had higher impact on screw withdrawal strength in comparison to the increase in resincontent from 8% to 10%. However, addition of NW resulted in a decrease in withdrawal capacity values at both resin levels in all directions.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"45 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80652262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-22DOI: 10.4172/2324-8777.1000226
Abdul Hadi Mahmud, A. Jani, M. Ali
The present study describes the synthesizing and attaching of betulinic acid-aminopropyl triethoxysilane (BA-APTES) on top of the nanoporous alumina (NA) surface. The NA was fabricated by using electrochemical anodization process under an applied voltage of 40 V for 20 hours resulting in average pore size of 45 nm characterized by Scanning Electron Microscope (SEM). The well-recognized therapeutic compound, betulinic acid (BA) was first extracted from the bark of Melaleuca cajuputi plant and further purified by column chromatography. The purified BA was incorporated with APTES using 1-hydroxybenzotriazole hydrate (HOBt) and O-(Benzotriazol-1-yl)-N,N,N’-tetramethyluronium hexafluorophosphate (HBTU) as a peptide coupling agent. The synthesized BA-APTES was silanized on top of the fabricated NA surface. The aromatic portion of 1H and 13C of the synthesized BA-APTES compound was validated by means of Nuclear Magnetic Resonance (NMR). The FTIR spectra show emerging peaks at 2900 cm-1 and 1250 cm-1 signifying the present of aldehyde and also aliphatic amine on NA, respectively. With the aid of XPS analysis, the chemical composition of BA-APTES has evidenced that the presence of the compounds on the surface of NA membrane. Hence, the authors suggest that the modified NA surface has a potential to be applied as a new material for therapeutic agent.
{"title":"Synthesis and Characterization of Betulinic Acid-Aminopropyltriethoxysilane Compounds and Their Assembly onto NanoporousAlumina Surfaces as Potential Therapeutic Agents","authors":"Abdul Hadi Mahmud, A. Jani, M. Ali","doi":"10.4172/2324-8777.1000226","DOIUrl":"https://doi.org/10.4172/2324-8777.1000226","url":null,"abstract":"The present study describes the synthesizing and attaching of betulinic acid-aminopropyl triethoxysilane (BA-APTES) on top of the nanoporous alumina (NA) surface. The NA was fabricated by using electrochemical anodization process under an applied voltage of 40 V for 20 hours resulting in average pore size of 45 nm characterized by Scanning Electron Microscope (SEM). The well-recognized therapeutic compound, betulinic acid (BA) was first extracted from the bark of Melaleuca cajuputi plant and further purified by column chromatography. The purified BA was incorporated with APTES using 1-hydroxybenzotriazole hydrate (HOBt) and O-(Benzotriazol-1-yl)-N,N,N’-tetramethyluronium hexafluorophosphate (HBTU) as a peptide coupling agent. The synthesized BA-APTES was silanized on top of the fabricated NA surface. The aromatic portion of 1H and 13C of the synthesized BA-APTES compound was validated by means of Nuclear Magnetic Resonance (NMR). The FTIR spectra show emerging peaks at 2900 cm-1 and 1250 cm-1 signifying the present of aldehyde and also aliphatic amine on NA, respectively. With the aid of XPS analysis, the chemical composition of BA-APTES has evidenced that the presence of the compounds on the surface of NA membrane. Hence, the authors suggest that the modified NA surface has a potential to be applied as a new material for therapeutic agent.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"30 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79891757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-22DOI: 10.4172/2324-8777.1000227
T. López, P. Larraza, E. Gómez
Today, cancer is one of the main causes of mortality. The most common treatments are chemotherapy, surgery, radiology and radiosurgery. The catalytic nanomedicine is a new research branch focused on the preparation of nanobiomaterials with medical applications to create a targeted therapy. The goal of this study was to determine the cytotoxic effect of the platinum nanoparticle (NPt) and the copper nanoparticle (NP-Cu) in lines of cancer cells as well as healthy cells for the cervical uterus cancer (HeLa), prostate cancer (DU 145). The catalyst nanoparticles used to break the bonds C-C, C-N and C=O in nitrogenous bases were synthesized in a sol-gel process. It is proven that they were biocompatible and non-toxic. Cell barriers were crossed with platinum and copper supported on functionalized titania (TiO2). In vitro tests were performed giving as a result that the NPt nanoparticles are much slower than the NP-Cu ones.
{"title":"Platinum and Copper Supported in Functionalized Titania Nanoparticles for the Treatment of Cervical and Prostate Cancer","authors":"T. López, P. Larraza, E. Gómez","doi":"10.4172/2324-8777.1000227","DOIUrl":"https://doi.org/10.4172/2324-8777.1000227","url":null,"abstract":"Today, cancer is one of the main causes of mortality. The most common treatments are chemotherapy, surgery, radiology and radiosurgery. The catalytic nanomedicine is a new research branch focused on the preparation of nanobiomaterials with medical applications to create a targeted therapy. The goal of this study was to determine the cytotoxic effect of the platinum nanoparticle (NPt) and the copper nanoparticle (NP-Cu) in lines of cancer cells as well as healthy cells for the cervical uterus cancer (HeLa), prostate cancer (DU 145). The catalyst nanoparticles used to break the bonds C-C, C-N and C=O in nitrogenous bases were synthesized in a sol-gel process. It is proven that they were biocompatible and non-toxic. Cell barriers were crossed with platinum and copper supported on functionalized titania (TiO2). In vitro tests were performed giving as a result that the NPt nanoparticles are much slower than the NP-Cu ones.","PeriodicalId":16457,"journal":{"name":"Journal of Nanomaterials & Molecular Nanotechnology","volume":"23 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79121052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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