Journal of oral biology and craniofacial research最新文献_第9页

Comparative evaluation of Hyaluronic acid and injectable platelet-rich fibrin as a non-surgical approach for management of black triangle 透明质酸与注射富血小板纤维蛋白非手术治疗黑三角的比较评价

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-10-08 DOI: 10.1016/j.jobcr.2025.09.030

Mansi Pal, Nand Lal, Umesh Pratap Verma, Anjani Kumar Pathak

Aims

To compare and evaluate the clinical efficacy of Hyaluronic Acid and Injectable Platelet Rich Fibrin (i-PRF) in the management of gingival black triangles using clinical and photographic analysis over 6 months.

Material and method

Thirty patients (15 in each group) were evaluated in this comparative study. Patients were divided into two groups: Group(HA) and Group(i-PRF). Injections were administered at baseline, 3 weeks, and 6 weeks. Black triangle height and area were measured at baseline, 1 month, 3 months, and 6 months using a UNC-15 probe and ImageJ software. Data were analyzed using repeated measures ANOVA and Tukey's post hoc test.

Results

Both the HA and i-PRF groups showed significant reductions in black triangle height and area over a 6-month period. HA reduced height by 0.80 mm at 1 month (p = 0.067), 1.47 mm at 3 months (p < 0.001), and 2.00 mm at 6 months (p < 0.001), while i-PRF reduced height by 1.20 mm (p = 0.003), 1.80 mm (p < 0.001), and 2.27 mm (p < 0.001) at the same intervals. Area reductions followed similar patterns. No significant intergroup differences were observed.

Conclusion

HA and i-PRF are effective, minimally invasive, and biocompatible treatments for managing black triangles. HA offers ease of use and patient comfort, while i-PRF is biologically driven and cost-effective. Material selection should be based on clinical conditions and patient preferences.

目的比较和评价透明质酸与富血小板纤维蛋白（i-PRF）治疗6个月牙龈黑三角的临床疗效。材料与方法30例患者（每组15例）进行比较研究。患者分为两组：HA组和i-PRF组。在基线、3周和6周进行注射。使用UNC-15探针和ImageJ软件在基线、1个月、3个月和6个月测量黑色三角形的高度和面积。数据分析采用重复测量方差分析和Tukey事后检验。结果在6个月的时间里，HA组和i-PRF组的黑三角高度和面积均有显著降低。HA在1个月降低高度0.80 mm (p = 0.067)，在3个月降低高度1.47 mm (p < 0.001)，在6个月降低高度2.00 mm (p < 0.001)，而i-PRF在相同的间隔降低高度1.20 mm (p = 0.003), 1.80 mm （p < 0.001）和2.27 mm （p < 0.001）。面积的减少也有类似的模式。各组间无显著差异。结论ha和i-PRF治疗黑三角是一种有效、微创、生物相容性好的治疗方法。HA提供了易用性和患者舒适度，而i-PRF是生物驱动的，具有成本效益。材料的选择应根据临床情况和患者的偏好。

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引用次数: 0

Clinical and radiographic success of single-cone bioceramic obturation versus traditional techniques: a systematic review and meta-analysis of randomized controlled trials 与传统技术相比，单锥生物陶瓷闭合术的临床和影像学成功：随机对照试验的系统回顾和荟萃分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-09-02 DOI: 10.1016/j.jobcr.2025.08.031

Firas Elmsmari , Yousef Elsayed , Abdelrahman Aboubakr , Mahdi Kaafarani , Osama Nour , Ajinkya M. Pawar

Background

Bioceramic sealers, known for their bioactivity and biocompatibility, offer a promising alternative to traditional resin-based sealers. However, clinical evaluations are lacking. This systematic review and meta-analysis compared the clinical and radiographic outcomes of bioceramic single-cone obturation with those of conventional treatment and sealers.

Methods

We conducted a systematic search of PubMed, ScienceDirect, and the Cochrane Library for randomized controlled trials (RCTs) published up to March 2024. Our review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD420250212604). Included studies compared bioceramic single-cone obturation with conventional obturation in permanent teeth with a follow-up of ≥6 months. Risk of bias was assessed using the second version of the Cochrane Risk of Bias tool (RoB 2.0). A random-effects meta-analysis was performed to calculate pooled success rates, odds ratios (ORs), and 95 % confidence intervals (CIs). Heterogeneity and publication bias were assessed via I² statistics and Egger's test.

Results

Three RCTs involving 259 participants met inclusion criteria. The success rates for the bioceramic group were 88.7 %, 87.1 %, and 92.0 % at 6, 12, and 18 months, respectively, while those for the controls were 76.4 %, 76.4 %, and 90.7 %, respectively. Three studies reported higher success rates in the bioceramic groups than in the controls, although between-group differences were not statistically significant (overall OR range 1.12–2.09; p > 0.05). We observed moderate heterogeneity at the early follow-ups and negligible heterogeneity at the 18-month follow-ups.

Conclusion

Single-cone obturation with bioceramic sealers may result in small but clinically relevant advantages; however, more high-quality RCTs with longer-term follow-up are needed.

生物陶瓷密封剂以其生物活性和生物相容性而闻名，为传统的树脂基密封剂提供了一个有希望的替代品。然而，缺乏临床评价。本系统综述和荟萃分析比较了生物陶瓷单锥封闭术与常规治疗和封闭术的临床和影像学结果。方法系统检索PubMed、ScienceDirect和Cochrane图书馆截至2024年3月发表的随机对照试验（rct）。我们的审查方案已在国际前瞻性系统评论注册（PROSPERO）（CRD420250212604）中注册。纳入的研究比较了生物陶瓷单锥体封闭与传统的恒牙封闭，随访时间≥6个月。使用第二版Cochrane偏倚风险工具（RoB 2.0）评估偏倚风险。随机效应荟萃分析计算合并成功率、优势比（ORs）和95%置信区间（ci）。通过I2统计量和Egger’s检验评估异质性和发表偏倚。结果3项随机对照试验共纳入259例受试者，符合纳入标准。在6、12、18个月时，生物陶瓷组的成功率分别为88.7%、87.1%、92.0%，而对照组的成功率分别为76.4%、76.4%、90.7%。三项研究报告生物陶瓷组的成功率高于对照组，但组间差异无统计学意义（总OR范围1.12-2.09;p > 0.05）。我们在早期随访中观察到中度异质性，在18个月的随访中观察到可忽略的异质性。结论生物陶瓷单锥封闭术虽小，但具有临床意义；然而，需要更多高质量、长期随访的随机对照试验。

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引用次数: 0

Comparative evaluation of antimicrobial properties and surface roughness of four maxillofacial prosthetic materials 四种颌面修复材料抗菌性能和表面粗糙度的比较评价

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-09-24 DOI: 10.1016/j.jobcr.2025.09.019

Zaihan Ariffin , Yanti Johari , Farhana Rahman , Suharni Mohamad , Nafij Bin Jamayet , James Dudley

Objectives

The adherence of microorganisms to the surfaces of maxillofacial prosthetic materials can cause surrounding tissue infections leading to discomfort, irritation and infection. It is therefore beneficial if maxillofacial prosthetic materials possess antimicrobial effects or resist microbial adherence. The purpose of this study was to compare the antimicrobial effect, surface roughness and microbial adherence of a locally produced modified polymethyl methacrylate maxillofacial prosthetic material with a commercially produced polymethyl methacrylate and two silicone elastomers against three microorganisms.

Methods

Four study groups were formed, each with 10 samples (n = 10): modified polymethyl methacrylate (m-PMMA), commercially produced polymethyl methacrylate (c-PMMA), silicone A-2000 (A-2000), and silicone A-2186 (A-2186). The microorganisms tested against the four prosthetic materials were Staphylococcus aureus (S. aureus), Streptococcus mutans (S. mutans), and Candida albicans (C. albicans). The antimicrobial effect, microbial adherence and surface roughness were assessed and scanning electron microscopy images examined surface roughness and microbial adherence.

Results

None of the tested materials showed antimicrobial activity against the evaluated microbial strains. Microbial adherence was significantly higher on silicone elastomers, with greater colony-forming units of both S. aureus and S. mutans compared to PMMA (p < 0.017). No significant difference was observed in C. albicans adherence between the silicone elastomers and PMMA. Surface roughness analysis revealed a statistically significant difference between PMMA and silicone elastomers (p < 0.05), with the silicones exhibiting greater roughness.

Conclusions

The fillers in m-PMMA may inhibit the release of antimicrobial agents. The locally produced m-PMMA demonstrated less microbial adherence in comparison to other tested materials.

Clinical implications

The locally produced m-PMMA was associated with less microbial adherence in comparison to other tested materials and has potential to reduce the risk of infection.

目的微生物附着于颌面部修复材料表面可引起周围组织感染，引起不适、刺激和感染。因此，如果颌面假体材料具有抗菌作用或抵抗微生物粘附是有益的。本研究的目的是比较本地生产的改性聚甲基丙烯酸甲酯颌面假体材料与商业生产的聚甲基丙烯酸甲酯和两种有机硅弹性体对三种微生物的抗菌效果、表面粗糙度和微生物粘附性。方法组成4个研究组，每组10个样品（n = 10）：改性聚甲基丙烯酸甲酯（m-PMMA）、市售聚甲基丙烯酸甲酯（c-PMMA）、硅胶A-2000 （A-2000）和硅胶A-2186 （A-2186）。对4种假体材料检测的微生物分别为金黄色葡萄球菌（S. aureus）、变形链球菌（S. mutans）和白色念珠菌（C. albicans）。评估了抗菌效果、微生物粘附性和表面粗糙度，扫描电子显微镜图像检查了表面粗糙度和微生物粘附性。结果所有材料均未显示出抑菌活性。与PMMA相比，有机硅弹性体上的微生物粘附性明显更高，金黄色葡萄球菌和变形葡萄球菌的集落形成单位都更大（p < 0.017）。在有机硅弹性体和PMMA之间，白色念珠菌粘附性没有显著差异。表面粗糙度分析显示PMMA和有机硅弹性体之间存在统计学差异（p < 0.05），有机硅弹性体表现出更大的粗糙度。结论m-PMMA填充剂可抑制抗菌药物的释放。与其他测试材料相比，本地生产的m-PMMA显示出较少的微生物粘附性。临床意义与其他测试材料相比，本地生产的m-PMMA具有较少的微生物粘附性，具有降低感染风险的潜力。

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引用次数: 0

Impact of hyaluronic acid filler on lip impressions: a cheiloscopic study 透明质酸填充物对唇印的影响：一项唇镜研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-08-27 DOI: 10.1016/j.jobcr.2025.08.025

Kananda Loiola Fernandes de Aguiar , Vandilson Pinheiro Rodrigues , Rafael Soares Diniz , Victor RM. Munoz-Lora , José Ferreira Costa , Letícia Machado Gonçalves-Soares

Objectives

The objective of this study was to evaluate, through cheiloscopic analysis, the impact of hyaluronic acid (HA) lip augmentation on lip impressions. Eleven patients underwent HA injections and had their lips analyzed for thickness, morphological classification, commissure position, and lip impression types at three time points: before treatment (T1), one month after (T2), and three months after (T3). Lip thickness was measured using a digital caliper, and commissure position was classified based on standardized digital photographs. For lip impression recording, lipstick was applied, and the lips were then pressed against a substrate. The types of lip grooves were determined after dividing the impression into eight quadrants. Data were statistically analyzed using repeated measures ANOVA and Fisher's exact test, with a significance level of 5 %.

Results

There was a significant increase in both upper and lower lip thickness, which remained stable after 3 months (p < 0,001). Regarding morphological classification, medium and mixed lips maintained their pattern in most cases, while thin lips became medium or mixed. No patient had “thick” or “very thick” lips after the treatment. There were also important changes in commissure position, particularly among patients with “lowered” commissures, which shifted to “horizontal.” No variations in lip impressions were observed across the quadrants examined at any time point.

Conclusion

The findings of this study suggest that, for purposes of human identification, the pattern of lip impressions remains unchanged after HA lip augmentation.

目的本研究的目的是通过唇镜分析，评估透明质酸（HA）丰唇对唇印的影响。11例患者接受血凝素注射，并在治疗前（T1）、治疗后1个月（T2）和治疗后3个月（T3）三个时间点分析唇部厚度、形态分类、连接位置和唇印类型。使用数字卡尺测量唇厚，并根据标准化的数字照片对接合位置进行分类。对于唇印记录，使用口红，然后将嘴唇压在基板上。将印模划分为八个象限，确定唇槽类型。数据采用重复测量方差分析和Fisher精确检验进行统计学分析，显著性水平为5%。结果患者上、下唇厚度均显著增加，3个月后保持稳定（p < 0.001）。在形态分类上，中等嘴唇和混合嘴唇在大多数情况下保持不变，而薄嘴唇则成为中等或混合嘴唇。治疗后没有患者出现“厚”或“非常厚”的嘴唇。交合位置也有重要的变化，特别是在“低”交合的患者中，交合位置转变为“水平”。在任何时间点检查的象限中都没有观察到唇印的变化。结论本研究结果表明，在HA丰唇后，唇印模式保持不变。

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引用次数: 0

Corrigendum to “Evaluation of sealant retention and caries prevention of 2 % chitosan-based pit and fissure sealants in permanent 1st molars – A randomised trial” [J Oral Biol Craniofac Res 15 (2025) 1490–1496] “评估2%壳聚糖基牙窝和牙缝密封剂在第一恒磨牙中的固位和龋预防作用——一项随机试验”[J]口腔生物与颅面杂志，15(2025):1490-1496。

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-12-20 DOI: 10.1016/j.jobcr.2025.09.012

Naina Kumar, Kavita Rai, Krithika Shetty, Manju Raman Nair

引用次数: 0

Oral health status, self-assessment and risk among tribes and narikuravars of Villupuramdistrict, Tamil Nadu – An epidemiological study 泰米尔纳德邦Villupuramdistrict部落和narikuravars的口腔健康状况、自我评估和风险——一项流行病学研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-08-20 DOI: 10.1016/j.jobcr.2025.08.018

V. Kalaivani (Dr), Arthi Balasubramaniam (Dr), I. Meignana Arumugham (Dr)

Background

Irular and Narikuravars, are the oldest Dravidian ethnic group and a semi-nomadic community people located in Tamil Nadu. Both the indigenous groups are relegated to the margins of society and face limited access to oral health care. Thus, we aimed to assess the normative need by assessing their oral health status and risks of Narikuravar and Irular tribes residing in Villupuram District, Tamil Nadu.

Method

ology: A cross-sectional epidemiological study with convenience sampling technique was conducted for 936 Irular and Narikuravar community people in Marakanam and Valavanur town panchayat of Dindivanam taluk of Villupuram district. Oral health status and self-assessment of oral health and risks was assessed using World Health Organization (WHO) oral health assessment form, self-oral health assessment form (2013).

Result

Narikuravar constitutes 32.8 % whereas Irula's constitute 67.2 % of the study population. Nearly 39.9 % of the study population had no formal schooling. Irular females with no formal schooling had high DMFT scores (3.27 ± 1.60). Also, the prevalence of gingivitis and periodontitis are high in Irular females with no formal schooling (32.3 % and 26 %) with no significant difference from Narikuravars. About 5.2 % of Narikuravar communities had high use of smoking and smokeless tobacco. Irulars consumed high cariogenic diet compared Narikuravars (p = 0.000).

Conclusion

Narikuvar community had more oral lesion compared to Irula's community people. Both communities had high prevalence of dental caries and periodontal disease. Females with no formal schooling of both communities had high caries experience, periodontitis.

dirular和Narikuravars是位于泰米尔纳德邦的最古老的德拉威民族和半游牧社区。这两个土著群体都处于社会边缘，获得口腔保健的机会有限。因此，我们旨在通过评估居住在泰米尔纳德邦Villupuram区的Narikuravar和Irular部落的口腔健康状况和风险来评估规范需求。方法：采用方便抽样方法，对维鲁布拉姆区丁迪瓦纳姆区马拉卡南和瓦拉瓦努尔镇村务委员会的936名Irular和Narikuravar社区居民进行了横断面流行病学调查。采用世界卫生组织（WHO）口腔健康评估表、口腔自我健康评估表（2013）对口腔健康状况和口腔健康风险自我评估进行评估。结果尼库拉瓦人占研究人群的32.8%，而伊鲁拉人占67.2%。近39.9%的研究人口没有受过正规教育。未受正规教育的不规则女性DMFT得分较高（3.27±1.60）。此外，牙龈炎和牙周炎的患病率在没有受过正规教育的不规则女性中也很高（32.3%和26%），与Narikuravars没有显著差异。约5.2%的Narikuravar社区吸烟和无烟烟草使用率很高。与Narikuravars相比，irular的饮食易患龋齿（p = 0.000）。结论narikuvar社区口腔病变发生率高于Irula社区。两个社区的龋齿和牙周病患病率均较高。两社区未接受正规教育的女性患龋齿、牙周炎的比例较高。

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引用次数: 0

Exploring knowledge gaps: A mixed-method cross-sectional study on Indian dental students’ perspectives and ethical awareness on artificial intelligence in dentistry 探索知识差距：印度牙科学生对牙科人工智能的观点和伦理意识的混合方法横断面研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-08-15 DOI: 10.1016/j.jobcr.2025.08.005

A. Subha , R. Poornima , M. Varshini

Introduction

In the realm of healthcare, Artificial Intelligence (AI) has emerged as a powerful tool with the potential to enhance diagnostics, treatment planning, and patient care. This comprehensive survey was conducted among dental students in India to better understand their knowledge, attitudes, and perceptions of the integration of AI in dentistry.

Materials and method

A structured questionnaire that consisted of both closed-ended and open-ended questions was designed to gather data on the students’ demographic information, knowledge, attitudes, and perceptions towards AI in dentistry. Additionally, their perspectives on ethical consideration related to AI use was also evaluated. The survey was carried out using Google Forms among 1256 dentistry students from 15 different states in India. Descriptive statistics, and inferential statistical analysis such as Chi-square test were performed to obtain the results.

Results

1256 dental students responded to the survey and there was a predominantly positive view towards AI in Dentistry. 94 % believed AI would lead to significant advances in dentistry, with 79 % finding it exciting. AI's diagnostic capabilities were high, with 89 % agreeing it can be used definitively and 85 % for prognostic purposes. Over 90 % supported AI for radiographic diagnosis of dental caries, periodontal disease, jaw pathologies, and soft tissue lesions. However, 59 % disagreed that AI could replace dentists. Knowledge of AI applications increased with the year of study, with postgraduate students showing the highest awareness. However, only 26 % of participants were aware of the ethical implications of using AI in dentistry, while 44 % were unaware and 30 % were unsure.

Conclusion

Most of the participants were aware of the potential benefits of integrating AI in dentistry. There is a need to focus on educating students about ethical concerns when teaching AI in dental education.

在医疗保健领域，人工智能（AI）已成为一种强大的工具，具有增强诊断、治疗计划和患者护理的潜力。这项综合调查是在印度的牙科学生中进行的，以更好地了解他们对人工智能在牙科中的整合的知识、态度和看法。材料和方法设计了一份结构化问卷，包括封闭式和开放式问题，以收集有关学生人口统计信息、知识、态度和对牙科人工智能的看法的数据。此外，还评估了他们对人工智能使用相关伦理考虑的看法。这项调查是在印度15个不同州的1256名牙科学生中使用谷歌表格进行的。采用描述性统计和卡方检验等推理统计分析得到结果。结果1256名牙科学生参与了调查，他们对牙科领域的人工智能持积极态度，94%的人认为人工智能将导致牙科领域的重大进步，79%的人认为人工智能令人兴奋。人工智能的诊断能力很高，89%的人认为它可以明确使用，85%的人认为它可以用于预后目的。超过90%的人支持人工智能用于龋齿、牙周病、颌骨病变和软组织病变的放射诊断。然而，59%的人不认为人工智能可以取代牙医。人工智能应用的知识随着学习年限的增加而增加，其中研究生的认知度最高。然而，只有26%的参与者意识到在牙科中使用人工智能的伦理影响，而44%的人不知道，30%的人不确定。大多数参与者都意识到将人工智能整合到牙科中的潜在好处。在牙科教育中教授人工智能时，有必要把重点放在对学生的道德问题教育上。

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引用次数: 0

Correlation between gingival fibroblast cell viability and degree of conversion of resin composites at different light-curing tip distances 不同光固化尖端距离下牙龈成纤维细胞活力与树脂复合材料转化程度的关系

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-10-22 DOI: 10.1016/j.jobcr.2025.10.011

Atieh Hashemian , Mahshid Hodjat , Marjan Behroozibakhsh

Objective

This study aimed to evaluate the effect of light-curing tip distance on the degree of conversion (DC), as well as on the cell viability. The study also aimed to assess the correlation between DC% and cell viability at different light-curing tip distances.

Materials and methods

Nanocomposite discs were cured using an LED light-curing unit at distances of 0 mm (G0), 2 mm (G2), 4 mm (G4), 6 mm (G6), and 8 mm (G8) for 20 s. The DC was measured using ATR-FTIR analysis. Cell viability was assessed through MTT assay on human gingival fibroblasts. The results were analyzed using one-way ANOVA and Pearson correlation analysis.

Results

The DC at the surface was significantly higher than the bottom of the samples in all groups (p < 0.001). The DC on both surfaces decreased as the distance between the light-curing unit and the sample surface increased. Moreover, with an increase in distance, the cell viability decreased. This difference was statistically significant in all groups, except for the G0 and G2 groups (p < 0.001). The results of Pearson correlation analysis showed a positive and statistically significant correlation between cell viability and DC% at both surfaces (p < 0.05). Furthermore, a negative and statistically significant correlation was observed between tip distance and DC% at both top and bottom surfaces as well as cell viability(p < 0.05).

Conclusion

Increasing the distance from the light-curing tip adversely affects composite polymerization and biocompatibility, likely due to insufficient curing and subsequent monomer and nanoparticle release. This study emphasizes the importance of optimal curing conditions.

目的探讨光固化尖端距离对细胞转化度（DC）及细胞存活率的影响。该研究还旨在评估不同光固化尖端距离下DC%与细胞活力之间的关系。材料与方法采用LED光固化装置，分别在0 mm （G0）、2 mm （G2）、4 mm （G4）、6 mm （G6）和8 mm （G8）的距离上固化纳米复合光盘，固化时间为20 s。DC采用ATR-FTIR分析测定。采用MTT法测定人牙龈成纤维细胞的细胞活力。结果采用单因素方差分析和Pearson相关分析。结果各组样品表面DC均显著高于底部DC （p < 0.001）。随着光固化单元与样品表面距离的增加，两个表面上的直流电流减小。而且，随着距离的增加，细胞活力降低。除G0和G2组外，所有组的差异均有统计学意义（p < 0.001）。Pearson相关分析结果显示，细胞活力与两表面DC%呈正相关且有统计学意义（p < 0.05）。此外，顶端距离与顶、底表面DC%以及细胞存活率呈显著负相关（p < 0.05）。结论增加与光固化尖端的距离可能会影响复合材料的聚合和生物相容性，这可能是由于光固化不足和随后的单体和纳米颗粒释放造成的。本研究强调了最佳养护条件的重要性。

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引用次数: 0

Artificial intelligence based techniques for caries risk prediction and assessment: A scoping review 基于人工智能的龋齿风险预测和评估技术：范围综述

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-09-10 DOI: 10.1016/j.jobcr.2025.08.027

Sonal Bhatia , Vinay Kumar Gupta , Sumit Kumar , Gaurav Mishra , Seema Malhotra , Khushboo Arif , Atrey Pai Khot , Aman Rajput , Angad Mahajan

Objective

The purpose of this scoping review was to systematically search through the evidence for the applications of artificial intelligence (AI) for caries risk assessment (CRA) or prediction (CRP), determine the scope of the methodologies used, summarize their performance metrics, and report limitations and challenges (if any).

Design

A structured and comprehensive search of three electronic databases, MEDLINE, EMBASE, and Google Scholar, was performed to yield results from 2013 to 2023. Studies were selected through title, abstract, and full-text screening based on the selection criteria. Charting of the extracted data was performed using a self-designed checklist with eight dimensions.

Results

The electronic database search retrieved 3059 articles. Ultimately, 13 articles were included in the review. The most used methods were logistic regression (n = 9) and random forest (n = 8). The performance of the included models was measured variably. The reported performance metrics of the models were heterogeneous in nature; the sensitivity ranged from 0.59 to 0.996, while the specificity ranged from 0.531 to 0.943. The most frequently utilized predictors include socio-demographic factors, oral hygiene habits, and dietary habits.

Conclusion

Of the AI-based CRA models analyzed, machine learning algorithms were most frequently used. This review highlights that AI methods most probably show superior specificity and better performance than traditional methods. The application of these algorithms can have significant implications for the population impacted by pertinent chronic diseases that are avoidable through risk reduction, such as dental caries.

本综述的目的是系统地检索人工智能（AI）用于龋齿风险评估（CRA）或预测（CRP）的证据，确定所使用方法的范围，总结其性能指标，并报告局限性和挑战（如果有的话）。对MEDLINE、EMBASE和谷歌Scholar三个电子数据库进行结构化和全面的检索，得出2013年至2023年的结果。根据选择标准通过标题、摘要和全文筛选来选择研究。使用自行设计的包含八个维度的检查表对提取的数据进行制图。结果电子数据库检索到文献3059篇。最终，13篇文章被纳入综述。使用最多的方法是逻辑回归（n = 9）和随机森林（n = 8）。所纳入模型的性能是可变的。报告的模型性能指标本质上是异构的；灵敏度为0.59 ~ 0.996，特异度为0.531 ~ 0.943。最常用的预测因素包括社会人口因素、口腔卫生习惯和饮食习惯。结论在分析的基于人工智能的CRA模型中，机器学习算法是最常用的。这篇综述强调了人工智能方法最有可能比传统方法表现出更好的特异性和更好的性能。这些算法的应用可以对受相关慢性疾病影响的人群产生重大影响，这些疾病可以通过降低风险来避免，例如龋齿。

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引用次数: 0

Mechanical properties and biocompatibility of graphene-reinforced materials for crowns and bridges: A systematic review and meta-analysis with emphasis on ceramics 石墨烯增强冠桥材料的力学性能和生物相容性：以陶瓷为重点的系统综述和荟萃分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-11-01 Epub Date: 2025-09-24 DOI: 10.1016/j.jobcr.2025.09.021

Anes Adnan Alshamaa , Ibrahim Hamad Alfahdawi , Mohamed Abdulmunem Abdulateef , Abdulkhaleq Mohammed Qaraghuli

Objective

This systematic review and meta-analysis investigated the mechanical characteristics and biocompatibility of graphene-reinforced materials, especially ceramics for dental crowns and bridges. Its goal was to synthesize the available evidence and highlight areas needed for future research.

Methods

A systematic search was conducted on PubMed, Web of Science, Science Direct, and Google Scholar, following the PRISMA guidelines. Eight in vitro studies were included which assessed biocompatibility and mechanical performance, such as flexural strength, compressive strength, and hardness. The QUIN tool was used to assess the risk of bias, and random-effects models were used for the meta-analysis.

Results

Graphene reinforcement significantly improved mechanical properties, with flexural strength increasing by ∼100 MPa in some ceramic systems (SMD: 1.26, 95 % CI: −0.20, 2.72) and hardness showing significant enhancement (SMD: 1.69, 95 % CI: 0.45, 2.94). Graphene oxide (GO) demonstrated antibacterial efficacy (SMD: 2.37, 95 % CI: 1.77, 2.97). Biocompatibility results were promising but limited by limited reporting. Variability in graphene type, concentration, and processing methods influenced outcomes.

Conclusion

Graphene-reinforced ceramics have superior mechanical characteristics and are potentially biocompatible, which solves some of the primary issues with existing dental materials. However, standardization of methodologies, long-term clinical validation, and optimization of graphene integration are essential for clinical translation.

目的对石墨烯增强材料的力学特性和生物相容性进行系统综述和荟萃分析。其目标是综合现有证据，突出未来研究需要的领域。方法按照PRISMA指南，在PubMed、Web of Science、Science Direct、b谷歌Scholar等网站进行系统检索。8项体外研究评估了生物相容性和机械性能，如抗弯强度、抗压强度和硬度。使用QUIN工具评估偏倚风险，并使用随机效应模型进行meta分析。结果石墨烯增强显著改善了陶瓷体系的力学性能，某些陶瓷体系的抗弯强度提高了~ 100 MPa (SMD: 1.26, 95% CI: - 0.20, 2.72)，硬度显著提高（SMD: 1.69, 95% CI: 0.45, 2.94）。氧化石墨烯（GO）具有抗菌效果（SMD: 2.37, 95% CI: 1.77, 2.97）。生物相容性结果是有希望的，但由于报道有限而受到限制。石墨烯类型、浓度和处理方法的可变性影响了结果。结论石墨烯增强陶瓷具有良好的力学性能和潜在的生物相容性，解决了现有牙科材料的一些主要问题。然而，方法的标准化、长期临床验证和石墨烯集成的优化对于临床转化至关重要。

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