Pub Date : 2021-06-12DOI: 10.9734/JPRI/2021/V33I31B31689
M. Srinivas, A. Singh
Aim: This research work was aimed to formulate Enhancing the solubility of Poorly soluble drug i.e. Fluvoxamine tablets by the solvent evaporation method, Fluvoxamine medicament is a selective serotonin reuptake inhibitor (SSRI) antidepressant agent. Purpose: The BCS class II drug Fluvoxamine consist low aqueous solubility and low oral bioavailability, for this reason to improve the biological performance of Fluvoxamine drug by solid dispersion mechanism. Methodolgy: The drug Fluvoxamine was formulated by using solvent evaporation technique, solid dispersions of Fluvoxamine were prepared with different carriers in different ratios of PEG 6000 & Mannitol (1:1, 1:2 and 1:3). Results: Results of prepared solid dispersions of Fluvoxamine by solid dispersion method Finally by comparing all the formulations, formulation (SF3) containing Fluvoxamine and PEG 6000 (1:3) shows better results. Original Research Article Srinivas and singh; JPRI, 33(31B): 44-53, 2021; Article no.JPRI.69597 45 Conclusion: Here we concluded that the poorly soluble drug solubility improving by solvent evaporation solid dispersion mechanism, and also developed six Fluvovamine formulations (FDF1FDF6) during this FDF4 shows maximum (98.9±0.8%) drug release at the end of time.
{"title":"Enhancement of Solubility and Dissolution Rate of BCS Class-II Fluvoxamine Tablets using Solvent Evaporation Solid Dispersion Technique","authors":"M. Srinivas, A. Singh","doi":"10.9734/JPRI/2021/V33I31B31689","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31689","url":null,"abstract":"Aim: This research work was aimed to formulate Enhancing the solubility of Poorly soluble drug i.e. Fluvoxamine tablets by the solvent evaporation method, Fluvoxamine medicament is a selective serotonin reuptake inhibitor (SSRI) antidepressant agent. Purpose: The BCS class II drug Fluvoxamine consist low aqueous solubility and low oral bioavailability, for this reason to improve the biological performance of Fluvoxamine drug by solid dispersion mechanism. Methodolgy: The drug Fluvoxamine was formulated by using solvent evaporation technique, solid dispersions of Fluvoxamine were prepared with different carriers in different ratios of PEG 6000 & Mannitol (1:1, 1:2 and 1:3). Results: Results of prepared solid dispersions of Fluvoxamine by solid dispersion method Finally by comparing all the formulations, formulation (SF3) containing Fluvoxamine and PEG 6000 (1:3) shows better results. Original Research Article Srinivas and singh; JPRI, 33(31B): 44-53, 2021; Article no.JPRI.69597 45 Conclusion: Here we concluded that the poorly soluble drug solubility improving by solvent evaporation solid dispersion mechanism, and also developed six Fluvovamine formulations (FDF1FDF6) during this FDF4 shows maximum (98.9±0.8%) drug release at the end of time.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48943223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-12DOI: 10.9734/JPRI/2021/V33I31B31688
Vinod Deora, G. Deora
Aims: Present study aims to evaluate the presence of bioactive compounds of Semibarbula orientalis (Pottiales: Pottiaceae), a bryophyte whole plant methanolic extract by Gas Chromatography-Mass Spectrometry (GC-MS) which are important medicinally as well flavouring and colouring agents. Study design: Qualitative preliminary phytochemical and GC-MS analysis. Place and duration of study: The study was carried out at Department of Botany, Center of Advanced Study, Jai Narain Vyas University, Jodhpur-Rajasthan (India) from January 2017 to December 2020. Methodology: The Preliminary phytochemical screening of S.orientalis was carried out qualitatively following the standard methods of Harbourne, Trease and Evans. GC-MS analysis was performed by GC-MS-QP 2010 Shimadzu, Japan equipped with thermal desorption system TD 20. Results: Preliminary phytochemical analysis revealed the presence of carbohydrates, proteins, phenols, sterols, flavonoids and terpenoids. GC-MS analysis of methanolic extract of whole plant Original Research Article Deora and Deora.; JPRI, 33(31B): 34-43, 2021; Article no.JPRI.69374 35 revealed the presence of 49 bioactive phytoconstituents which include mainly n-Hexadecanoic acid, Cis-vaccenic acid, Azulene, Hexadecanoic acid metyl ester, 1,3-Propanediol, 2-(hydroxyl methyl)-2-nitro, 9-12 Octadecadienol chloride (z,z), Octadecanoic acid etc. Conclusion: Preliminary phytochemical and GC-MS profiling of methanolic extract Semibarbula orientalis whole plant showed the presence of high value bioactive compounds with important medicinal properties and other uses in food industries as flavouring and colouring agents.
目的:采用气相色谱-质谱联用技术，对苔藓植物全植物甲醇提取物半barbula orientalis (Pottiales: Pottiaceae)中重要的药用、调味、着色剂等生物活性物质的含量进行评价。研究设计:定性初步植物化学和GC-MS分析。研究地点和时间:该研究于2017年1月至2020年12月在印度焦特布尔-拉贾斯坦邦贾伊纳拉因维亚斯大学高级研究中心植物系进行。方法学:采用Harbourne、Trease和Evans标准方法对东方红进行初步的植物化学定性筛选。采用日本Shimadzu公司的GC-MS- qp 2010，配备热解吸系统TD 20进行GC-MS分析。结果:初步的植物化学分析显示存在碳水化合物、蛋白质、酚类、甾醇、黄酮类和萜类化合物。全株牡丹甲醇提取物的GC-MS分析地球物理学报，33(31b): 34-43, 2021;文章no.JPRI。69374 35鉴定出49种植物活性成分，主要包括正十六烷酸、顺式异戊酸、Azulene、十六烷酸甲酯、1,3-丙二醇、2-(羟基甲基)-2-硝基、9-12十八烯二醇氯(z,z)、十八烷酸等。结论:半西番莲全株甲醇提取物的初步植物化学和气相色谱-质谱分析显示其含有高价值的生物活性化合物，具有重要的药用价值和在食品工业中作为调味剂和着色剂的其他用途。
{"title":"Semibarbula orientalis (Web.) Wijk. and Marg: A Potential Source of Bioactive and High Value Phytochemicals","authors":"Vinod Deora, G. Deora","doi":"10.9734/JPRI/2021/V33I31B31688","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31688","url":null,"abstract":"Aims: Present study aims to evaluate the presence of bioactive compounds of Semibarbula orientalis (Pottiales: Pottiaceae), a bryophyte whole plant methanolic extract by Gas Chromatography-Mass Spectrometry (GC-MS) which are important medicinally as well flavouring and colouring agents. Study design: Qualitative preliminary phytochemical and GC-MS analysis. Place and duration of study: The study was carried out at Department of Botany, Center of Advanced Study, Jai Narain Vyas University, Jodhpur-Rajasthan (India) from January 2017 to December 2020. Methodology: The Preliminary phytochemical screening of S.orientalis was carried out qualitatively following the standard methods of Harbourne, Trease and Evans. GC-MS analysis was performed by GC-MS-QP 2010 Shimadzu, Japan equipped with thermal desorption system TD 20. Results: Preliminary phytochemical analysis revealed the presence of carbohydrates, proteins, phenols, sterols, flavonoids and terpenoids. GC-MS analysis of methanolic extract of whole plant Original Research Article Deora and Deora.; JPRI, 33(31B): 34-43, 2021; Article no.JPRI.69374 35 revealed the presence of 49 bioactive phytoconstituents which include mainly n-Hexadecanoic acid, Cis-vaccenic acid, Azulene, Hexadecanoic acid metyl ester, 1,3-Propanediol, 2-(hydroxyl methyl)-2-nitro, 9-12 Octadecadienol chloride (z,z), Octadecanoic acid etc. Conclusion: Preliminary phytochemical and GC-MS profiling of methanolic extract Semibarbula orientalis whole plant showed the presence of high value bioactive compounds with important medicinal properties and other uses in food industries as flavouring and colouring agents.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"34-43"},"PeriodicalIF":0.0,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45432568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-12DOI: 10.9734/JPRI/2021/V33I31B31691
V. K. Singh, R. Dhande, G. Mishra
Background: Acute pancreatitis is one of the most common abdominal pathologies having variable outcome ranging from self limiting abdominal pain to high mortality and morbidity due to organ failure, over the past five decades, various classification systems have emerged to classify pancreatitis according to its severity , and the associated complications have emerged to classify acute pancreatitis and its various complications, such as Apache Scoring , Ct Severity , Modified Ct Severity ,Ransen and Atlanta Classification. Objectives: We in our study will be classifying patients suffering from acute pancreatitis according to the revised Atlanta classification to divide them into interstitial edematous pancreatitis and necrotizing pancreatitis. The local complications will be classified according to CT imaging findings into acute necrotic collection, psuedocyst, acute necrotic collection and walled of necrosis. Organ failure will be assessed according to modified marshal scoring system into transient or persistent organ failure. Methodology: We will be carrying forward our study on Siemens 16 slice computer tomography machine over a sample of 140 patients coming to the outpatient department of our hospital which will be followed by a routine clinical follow up of the patient to find out their prognosis. Study Protocol Singh et al.; JPRI, 33(31B): 61-68, 2021; Article no.JPRI.68602 62 Results: Will be tabulated at the end of the study using SPSS version 26 software. Conclusion: The revised Atlanta classification for acute pancreatitis, in conjunction with the Modified Marshall Scoring System for organ failure, if found useful, in our series in improving the prognosis of the patients, then it can be incorporated in management.
{"title":"Atlanta Classification for Acute Pancreatitis- A Study Protocol","authors":"V. K. Singh, R. Dhande, G. Mishra","doi":"10.9734/JPRI/2021/V33I31B31691","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31691","url":null,"abstract":"Background: Acute pancreatitis is one of the most common abdominal pathologies having variable outcome ranging from self limiting abdominal pain to high mortality and morbidity due to organ failure, over the past five decades, various classification systems have emerged to classify pancreatitis according to its severity , and the associated complications have emerged to classify acute pancreatitis and its various complications, such as Apache Scoring , Ct Severity , Modified Ct Severity ,Ransen and Atlanta Classification. Objectives: We in our study will be classifying patients suffering from acute pancreatitis according to the revised Atlanta classification to divide them into interstitial edematous pancreatitis and necrotizing pancreatitis. The local complications will be classified according to CT imaging findings into acute necrotic collection, psuedocyst, acute necrotic collection and walled of necrosis. Organ failure will be assessed according to modified marshal scoring system into transient or persistent organ failure. Methodology: We will be carrying forward our study on Siemens 16 slice computer tomography machine over a sample of 140 patients coming to the outpatient department of our hospital which will be followed by a routine clinical follow up of the patient to find out their prognosis. Study Protocol Singh et al.; JPRI, 33(31B): 61-68, 2021; Article no.JPRI.68602 62 Results: Will be tabulated at the end of the study using SPSS version 26 software. Conclusion: The revised Atlanta classification for acute pancreatitis, in conjunction with the Modified Marshall Scoring System for organ failure, if found useful, in our series in improving the prognosis of the patients, then it can be incorporated in management.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41972344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-12DOI: 10.9734/JPRI/2021/V33I31B31692
Poonam Madan, B. Rathi, Renu Rathi, S. Wairagade, D. Zade
Introduction: Dandruff is a commonly found hair problem affecting all age groups with high recurrence and is considered a social stigma. In Ayurved it is compared with Darunak falling under the category of kshudrarogadhikar and is caused due to the vitiation of vaat and kapha. Traditionally the treatment comprises of application of oil, steaming, applying packs, washing of hair etc. According to modern science dandruff is a non-treatable disease condition which is prevented by use of anti-dandruff shampoos, creams and hair masks. The available products are expensive and results are not very satisfactory and recurrence is common. Currently treatment available for dandruff is found to be expensive with unsatisfactory results in terms of recurrence of symptoms. Aim and objective: Pharmaceutical development, standardization and clinical evaluation of efficacy of a polyherbal Hair pack and Hair gel in dandruff control Materials and methods: Hair pack will be made with selected drugs like Amalki, Bibhitaki, Haritaki, Japa, Yashtimadhu, Musta, Brahmi and it will be converted into gel form. Analytical study for standardization of powder and gel dosage form will be done. Clinical evaluation of both dosage forms for efficacy will be done. Observations and results: Observation will be done on the basis of photographic evaluation of the condition of pre and post severity of symptoms and duration of recurrence time of dandruff will be noted. Results will be drawn on the basis of observations and applying suitable tests. It will be noted and presented in form of table, charts, graphs etc. Conclusion: Currently available treatment for dandruff does not provide complete remission of symptoms for long duration and it is very expensive too. Thus the newly designed herbal formulation is aimed to provide significant result in controlling dandruff and its associated symptoms and modified dosage i.e. gel will overcome the limitation of powder and provide a cost effective cosmetic product in controlling dandruff.
{"title":"Pharmaceutical Development, Standardization and Clinical Evaluation of Efficacy of a Polyherbal Hair-Pack and Hair Gel in Dandruff Control","authors":"Poonam Madan, B. Rathi, Renu Rathi, S. Wairagade, D. Zade","doi":"10.9734/JPRI/2021/V33I31B31692","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31692","url":null,"abstract":"Introduction: Dandruff is a commonly found hair problem affecting all age groups with high recurrence and is considered a social stigma. In Ayurved it is compared with Darunak falling under the category of kshudrarogadhikar and is caused due to the vitiation of vaat and kapha. Traditionally the treatment comprises of application of oil, steaming, applying packs, washing of hair etc. According to modern science dandruff is a non-treatable disease condition which is prevented by use of anti-dandruff shampoos, creams and hair masks. The available products are expensive and results are not very satisfactory and recurrence is common. Currently treatment available for dandruff is found to be expensive with unsatisfactory results in terms of recurrence of symptoms. \u0000Aim and objective: Pharmaceutical development, standardization and clinical evaluation of efficacy of a polyherbal Hair pack and Hair gel in dandruff control \u0000Materials and methods: Hair pack will be made with selected drugs like Amalki, Bibhitaki, Haritaki, Japa, Yashtimadhu, Musta, Brahmi and it will be converted into gel form. Analytical study for standardization of powder and gel dosage form will be done. Clinical evaluation of both dosage forms for efficacy will be done. \u0000Observations and results: Observation will be done on the basis of photographic evaluation of the condition of pre and post severity of symptoms and duration of recurrence time of dandruff will be noted. Results will be drawn on the basis of observations and applying suitable tests. It will be noted and presented in form of table, charts, graphs etc. \u0000Conclusion: Currently available treatment for dandruff does not provide complete remission of symptoms for long duration and it is very expensive too. Thus the newly designed herbal formulation is aimed to provide significant result in controlling dandruff and its associated symptoms and modified dosage i.e. gel will overcome the limitation of powder and provide a cost effective cosmetic product in controlling dandruff.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41418145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-11DOI: 10.9734/JPRI/2021/V33I31A31679
Tazeen Shah, S. Dars, Saima Sheikh, F. Shaikh, S. Ansari, N. Akhtar, Arslan Ahmer
Objective: To evaluate the effects of Green tea on obesity and hyperglycemia. Methodology: This observational study was carried out at the department of physiology, in affiliation to Medical Research Centre Liaquat University of Medical and Health Sciences Jamshoro. The sample was collected by convenient random sampling. Total 100 participants, 50 controls and 50 obese diabetics were enrolled. Informed written consent was taken from participants. The body mass index (BMI) of the participants was taken at the time of recruitment, Original Research Article Shah et al.; JPRI, 33(31A): 183-187, 2021; Article no.JPRI.69895
目的:探讨绿茶对肥胖和高血糖的影响。方法:这项观察性研究是在生理学系进行的，隶属于利奎特医学和健康科学大学贾姆肖洛医学研究中心。采用方便的随机抽样方法采集样本。总共有100名参与者，50名对照组和50名肥胖糖尿病患者。获得参与者的知情书面同意。在招募时测量参与者的身体质量指数(BMI)，原文Shah et al.;地球物理学报，33(31):183-187,2021;文章no.JPRI.69895
{"title":"Role of Green Tea on Obesity and Type-II Diabetes Mellitus Male Individuals","authors":"Tazeen Shah, S. Dars, Saima Sheikh, F. Shaikh, S. Ansari, N. Akhtar, Arslan Ahmer","doi":"10.9734/JPRI/2021/V33I31A31679","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31A31679","url":null,"abstract":"Objective: To evaluate the effects of Green tea on obesity and hyperglycemia. Methodology: This observational study was carried out at the department of physiology, in affiliation to Medical Research Centre Liaquat University of Medical and Health Sciences Jamshoro. The sample was collected by convenient random sampling. Total 100 participants, 50 controls and 50 obese diabetics were enrolled. Informed written consent was taken from participants. The body mass index (BMI) of the participants was taken at the time of recruitment, Original Research Article Shah et al.; JPRI, 33(31A): 183-187, 2021; Article no.JPRI.69895","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"183-187"},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48121702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-11DOI: 10.9734/JPRI/2021/V33I31B31680
S. Kamble, A. Wanjari, B. Rathi, D. Rajput
Background: Shukti (Oyster) is a very commonly occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two forms which are bhasma (calcinated ash) and pishti (powdered form without agni).These forms may have different rate of absorption. This needs to be studied. Aim: To study Pharmaceutico-analytical study of Muktashukti pishti & Muktashukti bhasma and comparative evaluation of their relative oral bioavailability. Materials and methods: The two formulations will be prepared from shukti (oyster). By triturating with Gulabjala Muktashukti pishti will be prepared and by traditional puta method Muktashukti bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, physicochemical parameters and Particle size distribution analysis, SEM-EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), GCMS (Gas Study Protocol Kamble et al.; JPRI, 33(31B): 1-9, 2021; Article no.JPRI.68599 2 Chromatography Mass Spectrometry) will be evaluated. To assess the relative oral bioavailability of Muktashukti pishti & Muktashukti bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement. The study will be conducted in between two test groups and standard group. Observation and results: The analytical parameters will be assessed and compared in Muktashukti bhasma and Muktashukti pishti. For relative oral bioavailability Blood serum calcium will be assessed in all three groups. By applying unpaired “t” Test, One-way ANOVA the statistical significance can be measured. Conclusion: The pharmaceutical & analytical study of Muktashukti pishti and Muktashukti bhasma will provide the standard parameters and clinical comparative evaluation with standard will generate evidence for better bioavailability.
{"title":"Pharmaceutico-Analytical Study of Muktashukti Pishti and Muktashukti bhasma and Comparative Evaluation of their Relative Oral Bioavailability","authors":"S. Kamble, A. Wanjari, B. Rathi, D. Rajput","doi":"10.9734/JPRI/2021/V33I31B31680","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31680","url":null,"abstract":"Background: Shukti (Oyster) is a very commonly occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two forms which are bhasma (calcinated ash) and pishti (powdered form without agni).These forms may have different rate of absorption. This needs to be studied. Aim: To study Pharmaceutico-analytical study of Muktashukti pishti & Muktashukti bhasma and comparative evaluation of their relative oral bioavailability. Materials and methods: The two formulations will be prepared from shukti (oyster). By triturating with Gulabjala Muktashukti pishti will be prepared and by traditional puta method Muktashukti bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, physicochemical parameters and Particle size distribution analysis, SEM-EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), GCMS (Gas Study Protocol Kamble et al.; JPRI, 33(31B): 1-9, 2021; Article no.JPRI.68599 2 Chromatography Mass Spectrometry) will be evaluated. To assess the relative oral bioavailability of Muktashukti pishti & Muktashukti bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement. The study will be conducted in between two test groups and standard group. Observation and results: The analytical parameters will be assessed and compared in Muktashukti bhasma and Muktashukti pishti. For relative oral bioavailability Blood serum calcium will be assessed in all three groups. By applying unpaired “t” Test, One-way ANOVA the statistical significance can be measured. Conclusion: The pharmaceutical & analytical study of Muktashukti pishti and Muktashukti bhasma will provide the standard parameters and clinical comparative evaluation with standard will generate evidence for better bioavailability.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45819505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-11DOI: 10.9734/JPRI/2021/V33I31A31677
A. Pimpale, R. Kakde
Aims: The current research work has desired the validated reversed-phase analytical technique for the assurance of rosuvastatin calcium in bulk and tablet formulation. Study design: Experimental research work. Place and duration of study: UDPS, RTM Nagpur University, Nagpur, Maharashtra State, India between June 2019 and March 2020. Methodology: The segregation was obtained on a reversed-phase Princeton (C18) column with dimensions (250mm × 4.6mm, 5μ). The solvent system employed was a mixture of buffer, and methanol in the proportion (20:80) v/v, flow rate one ml per minute. Detection wavelength at 240 nm. The retention time (RT)beneath the developed chromatographic condition was found to be 2.848 minutes for rosuvastatin calcium. Results: The technique indicates linearity within the range of 2-16 μg per ml with a correlation Original Research Article Pimpale and Kakde; JPRI, 33(31A): 164-171, 2021; Article no.JPRI.68217 165 coefficient (r) is 0.9999. The analysis of marketed tablet formulations was erect to be 99.98%. The percentage RSD was ˂2% and % recovery was found to be 97.94-100.37%. Conclusion: The advanced reversed-phase HPLC technique was erect to be simple, specific, linear, sensitive, rapid, accurate, precise, economical, and can be utilized for daily quality control of rosuvastatin calcium in tablet and bulk formulations.
{"title":"A Validated Reversed-Phase HPLC Analytical Method for the Analysis of Rosuvastatin Calcium in Bulk Drug and Tablet Dosage Formulation","authors":"A. Pimpale, R. Kakde","doi":"10.9734/JPRI/2021/V33I31A31677","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31A31677","url":null,"abstract":"Aims: The current research work has desired the validated reversed-phase analytical technique for the assurance of rosuvastatin calcium in bulk and tablet formulation. Study design: Experimental research work. Place and duration of study: UDPS, RTM Nagpur University, Nagpur, Maharashtra State, India between June 2019 and March 2020. Methodology: The segregation was obtained on a reversed-phase Princeton (C18) column with dimensions (250mm × 4.6mm, 5μ). The solvent system employed was a mixture of buffer, and methanol in the proportion (20:80) v/v, flow rate one ml per minute. Detection wavelength at 240 nm. The retention time (RT)beneath the developed chromatographic condition was found to be 2.848 minutes for rosuvastatin calcium. Results: The technique indicates linearity within the range of 2-16 μg per ml with a correlation Original Research Article Pimpale and Kakde; JPRI, 33(31A): 164-171, 2021; Article no.JPRI.68217 165 coefficient (r) is 0.9999. The analysis of marketed tablet formulations was erect to be 99.98%. The percentage RSD was ˂2% and % recovery was found to be 97.94-100.37%. Conclusion: The advanced reversed-phase HPLC technique was erect to be simple, specific, linear, sensitive, rapid, accurate, precise, economical, and can be utilized for daily quality control of rosuvastatin calcium in tablet and bulk formulations.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"164-171"},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41727252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-11DOI: 10.9734/JPRI/2021/V33I31A31687
Zunair Khalid, G. Yasin, A. Altaf, Syeda Amna Batool, Asma Kanwal, Sobia Sohail
The presence of secondary metabolites and various ions in a plant determines its phytophamacological potential. Desert plants are adapted to stressful environmet by synthesizing secondary metabolites and ions accumulation as osmoticum.The present study was conducted to evaluate the pharmacological potential of Thal desert plants in term of their metabolites and nutrient ions concentrations. Five specimens of seasonally available herbs and three of trees of Thal desert plants were colected. After collection specimens were analysed for alkaloids, terpenoids, tannins, sugar and ion contents. The data were analyzed statistically and means were compared by Duncan’s Multiple Range Test. Among the herbs Panicum antidotale root showed highest terpenoid, K ion and Ca ion contents. The herb Aerva javanica stem showed lowest alkaloid, tannin, soluble sugar, phosphorus, potassium and calcium contents. Among trees specimens, Tamarix aphylla leaves showed highest soluble sugar, phosphorous, potassium and calcium contents. Stem of Acacia modesta showed the lowest alkaloid, terpenoid, phosphorous and potassium contents. Original Research Article Khalid et al.; JPRI, 33(31A): 217-226, 2021; Article no.JPRI.69790
植物体内次生代谢物和各种离子的存在决定了植物的危害潜能。荒漠植物通过次生代谢产物的合成和离子的渗透积累来适应逆境环境。本研究从荒漠植物的代谢物和营养离子浓度方面对其药理潜力进行了评价。收集了5种时令草本植物和3种乔木。采集标本后进行生物碱、萜类、单宁、糖和离子含量分析。数据进行统计学分析，均数比较采用Duncan多元极差检验。解毒参的萜类、钾离子和钙离子含量最高。水芹茎的生物碱、单宁、可溶性糖、磷、钾和钙含量最低。柽柳叶片的可溶性糖、磷、钾和钙含量最高。黄豆茎中生物碱、萜类、磷、钾含量最低。Khalid et al.;地球物理学报，33(31):217- 226,2021;文章no.JPRI.69790
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Pub Date : 2021-06-11DOI: 10.9734/JPRI/2021/V33I31A31676
Aneela Tehzeen, Hazooran Lakhan, S. Awan, M. Rani, Shahida Baloch, M. Suhail, Arslan Ahmer
Objective: To analyze the clinical characteristics of urogenital fistulas reported at PMCH Nawabshah. Methodology: A cross-sectional study, concluded in three years from January 2018 to December, 2020 in all ages patients with urogenital fistulas (UGF). The referred cases of UGF to gynecology and Urology Departments of the PMCH Nawabshah. The females with UGF results after elective Original Research Article Tehzeen et al.; JPRI, 33(31A): 157-163, 2021; Article no.JPRI.69823 158 caesarean section and gynecologic surgery including hysterectomy, prolapse repair and myomectomy were included whereas patients with UGF results due to other operative measures which includes emergency caesarian section, traumatic and congenital were excluded from this study. The data were analyzed thru SPSS version 22.0. Results: Total 247 patients were included in present study. The age of patients were 20 years to 66 years with mean age 38.99+SD7.992. Frequency and percentages of different variables that were included in this study were for the demographic and co morbidities. Majority of patients were from rural setup, house wives having low education profile, belonging to low socioeconomically and educational status. DM and HTN were the common co-morbidities observed in study population. The different frequencies and percentages were calculated for the different surgical procedure adopted before the development of fistulas, UVF and OF was assessed in different procedures. Hysterectomies was most common surgical procedure than C/S and others. P value was statistically insignificant here 0.696. Wound infections were also seen in post operated cases with high ratios due to contaminations; wound infection was present in 20.6% cases, which was very high. Conclusion: Present study revealed that the many of urogenital fistulas treated and repaired patients at our hospital setup, associated with iatrogenic obstetric origin and no any patients of UGF associated with obstructed laboras it is contrasting with other developing countries. Recorded fistulas were cured after the first surgical repair.
目的:分析纳瓦布沙医院泌尿生殖系统瘘的临床特点。方法:一项横断面研究，从2018年1月到2020年12月，在所有年龄段的泌尿生殖瘘管(UGF)患者中完成。将UGF的病例转诊到纳瓦布沙妇产医院的妇科和泌尿科。选课后UGF成绩的女性tezeen et al;地球物理学报，33(31):157-163,2021;文章no.JPRI。69823 158剖宫产和妇科手术包括子宫切除术、脱垂修复和子宫肌瘤切除术被纳入研究，而由于其他手术措施(包括紧急剖宫产、外伤性和先天性)导致的UGF结果被排除在本研究之外。数据采用SPSS 22.0进行分析。结果:本研究共纳入247例患者。患者年龄20 ~ 66岁，平均年龄38.99+SD7.992。本研究中包含的不同变量的频率和百分比用于人口统计学和合并症。患者多为农村家庭妇女，文化程度低，社会经济、文化程度低。糖尿病和HTN是研究人群中常见的合并症。在瘘形成前计算不同手术方式的不同频率和百分比，评估不同手术方式下的UVF和of。子宫切除术是最常见的外科手术，而不是C/S和其他手术。P值为0.696，差异无统计学意义。术后伤口感染的发生率也很高，原因是污染;伤口感染占20.6%，发生率很高。结论:与其他发展中国家相比，我院治疗和修复的泌尿生殖系统瘘患者多与医源性产科有关，没有一例泌尿生殖系统瘘患者与阴道梗阻有关。记录的瘘管在第一次手术修复后治愈。
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Pub Date : 2021-06-11DOI: 10.9734/JPRI/2021/V33I31A31678
Revathi A. Gupta, P. O. Kumar
Pioglitazone is designated as a BCS class II medication since it is weakly water soluble.The goal of this study was to create starch nanoparticles for the administration of Pioglitazone in attempt to lessen dose-related side effects and maybe prolong its release in the treatment of diabetes.Using starch as a polymer, tween 80 as a stearic barrier, and citric acid to enhance stability, nanoparticles were constructed using the solvent evaporation technique. In-vitro characterization techniques for drug-polymer compatibility, size, surface morphology, encapsulation efficacy, and delivery properties were performed on framed nanoparticles, followed by In-vivo studies.The compatible nature of selected excipients for the manufacture of Pioglitazone nanoparticles was shown by FTIR findings.The results of the XRD analysis revealed that the generated Pioglitazone nanoparticles were non-crystalline in nature.The selected developed Pioglitazone nanoparticles were in cubic phase with average particle size of 160.5 ± 11.24–245.4 ± 15.96 nm with charge ranging from 10.5 ± 6.21-138.6 ± 5.31mV.The encapsulation efficiency of Pioglitazone nanoparticles produced ranged from 57.24 5.80 to 89.96 1.9%. The In-vitro drug release studies of Pioglitazone nanoparticles showed controlled drug release profile. Furthermore, In-vivo investigations on blood glucose profiles revealed that the created Pioglitazone nanoparticles for the treatment of diabetes mellitus had a substantial effect. Original Research Article Gupta and Odayakumar; JPRI, 33(31A): 172-182, 2021; Article no.JPRI.69332 173
{"title":"Development and Characterization of Pioglitazone Nanoparticles for the Effective Treatment of Diabetes Mellitus","authors":"Revathi A. Gupta, P. O. Kumar","doi":"10.9734/JPRI/2021/V33I31A31678","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31A31678","url":null,"abstract":"Pioglitazone is designated as a BCS class II medication since it is weakly water soluble.The goal of this study was to create starch nanoparticles for the administration of Pioglitazone in attempt to lessen dose-related side effects and maybe prolong its release in the treatment of diabetes.Using starch as a polymer, tween 80 as a stearic barrier, and citric acid to enhance stability, nanoparticles were constructed using the solvent evaporation technique. In-vitro characterization techniques for drug-polymer compatibility, size, surface morphology, encapsulation efficacy, and delivery properties were performed on framed nanoparticles, followed by In-vivo studies.The compatible nature of selected excipients for the manufacture of Pioglitazone nanoparticles was shown by FTIR findings.The results of the XRD analysis revealed that the generated Pioglitazone nanoparticles were non-crystalline in nature.The selected developed Pioglitazone nanoparticles were in cubic phase with average particle size of 160.5 ± 11.24–245.4 ± 15.96 nm with charge ranging from 10.5 ± 6.21-138.6 ± 5.31mV.The encapsulation efficiency of Pioglitazone nanoparticles produced ranged from 57.24 5.80 to 89.96 1.9%. The In-vitro drug release studies of Pioglitazone nanoparticles showed controlled drug release profile. Furthermore, In-vivo investigations on blood glucose profiles revealed that the created Pioglitazone nanoparticles for the treatment of diabetes mellitus had a substantial effect. Original Research Article Gupta and Odayakumar; JPRI, 33(31A): 172-182, 2021; Article no.JPRI.69332 173","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"172-182"},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41359253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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