Journal of periodontology最新文献

{"title":"Validity of a self-reported questionnaire for periodontal status in a Thai population.","authors":"Chutinun Chaiwut,Chidchanok Ruengorn,Panwadee Bandhaya","doi":"10.1002/jper.24-0707","DOIUrl":"https://doi.org/10.1002/jper.24-0707","url":null,"abstract":"BACKGROUNDA self-reported questionnaire developed by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) has demonstrated adequate reliability for evaluating periodontal status in national surveillance surveys--which has been translated and validated in multiple languages--but has not yet been tested in Thai. Therefore, this cross-sectional study evaluated the validity of the CDC/AAP self‑report questionnaire for periodontitis in a Thai population.METHODSThe Thai version of CDC/AAP self-reported questionnaire was developed. Full-mouth periodontal examinations were performed, and periodontitis was diagnosed using CDC/AAP 2012 or European Federation of Periodontology (EFP)/AAP 2018 case definition. Association between questionnaire responses and a periodontitis diagnosis was assessed using multiple regression modeling. Several predictive models were constructed and their validity assessed using receiver operating characteristic curves.RESULTSThe study included 250 participants resided in Chiang Mai, Thailand, aged 20-82 years, with 83.6% and 84.4% diagnosed with periodontitis based on CDC/AAP 2012 and EFP/AAP 2018 case definitions, respectively. CDC/AAP questions revealed a satisfactory performance in predicting CDC/AAP-defined severe periodontitis and EFP/AAP-defined stage III/IV periodontitis. Additional questions regarding demographic data and periodontal risk factors improved the performance. Reduced model constructed using stepwise regression yielded sensitivity versus specificity of 57.8% versus 84.0% and 79.4% versus 81.4% for predicting CDC/AAP-defined severe periodontitis and EFP/AAP-defined stage III/IV periodontitis, respectively.CONCLUSIONSThe questionnaire in Thai version demonstrated better performance in predicting advanced stages of periodontitis when combined with demographic variables and periodontal risk factors. Our findings highlight the potential utility of this tool in diverse populations.PLAIN LANGUAGE SUMMARYDespite being one of the most common diseases in humans, periodontal disease diagnosis is not easy at the individual and surveillance levels. Efforts have been made to assemble tools to ease the process, and questionnaires are an auspicious tool. This study aimed to validate the self-reported questionnaire developed by the US Centers for Disease Control and Prevention in collaboration with the American Academy of Periodontology for predicting periodontal disease in the Thai population. The validity of the questionnaires was assessed by comparing the self-reported responses to the data collected through a full-mouth examination by a third-year resident from the Periodontology Residency Training Program. In our study, questions related to signs of the disease showed promising validity as a predictive variable for periodontitis, especially its severe form, and the questionnaires performed better when used together with other questions, such as age and education level.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"111 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145381000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between periodontitis and gestational diabetes mellitus via systemic inflammation: A prospective cohort study.","authors":"Jing Cheng,Yun Tao,Qian Gong,Juan Liu,Cheng Wang,Yujuan Li,Hong Luo,Jinmeng Xi,You Wang,Wei Gao,Bo Cheng","doi":"10.1002/jper.70026","DOIUrl":"https://doi.org/10.1002/jper.70026","url":null,"abstract":"BACKGROUNDThis study aimed to investigate the association between periodontitis severity and the risk of gestational diabetes mellitus (GDM) considering pathways induced by systemic inflammation.METHODSPregnant women with singleton pregnancies aged at least 18 years at 12-20 gestational weeks were enrolled in the study. Logistic and linear regression models were constructed to examine the associations between periodontal status and GDM risk and blood glucose levels. Age-stratified analyses (≥ 30 vs. < 30 years) were conducted to evaluate potential effect modification. Lastly, mediation analysis was employed to assess the proportion of the association mediated by systemic inflammatory biomarkers.RESULTSOut of 446 participants, the overall incidence of GDM was 26.68%. It increased with the severity of periodontal disease, reaching a 3-fold higher GDM risk among women with stages II-IV periodontitis compared to healthy controls [17.35% vs. 38.60%; odds ratio (OR) = 3.00, 95% confidence interval (95% CI): 1.38-6.67, p < 0.05]. Stratified analyses showed this association was restricted to women aged ≥ 30 years (p for interaction < 0.05), with a 4.78-fold higher GDM risk in women having stages II-IV periodontitis (OR = 4.78, 95% CI: 1.85-13.08; p < 0.05). Even women with stage I periodontitis exhibited a significant association (OR = 2.84, 95% CI: 1.25-6.92, p < 0.05). Mediation analysis revealed that systemic inflammatory markers [white blood cell (WBC), neutrophils, systemic immune inflammation index (SII), aggregate index of systemic inflammation (AISI)] partially mediated the link between stages II-IV periodontitis and GDM, with mediation proportions of 17.85%, 18.61%, 17.32%, and 11.71%, respectively.CONCLUSIONIncreasing periodontitis severity was significantly associated with a higher risk of GDM in a dose-response manner in women aged ≥ 30 years, but not in younger women. Besides, systemic inflammation may partially mediate this association, suggesting a biological link between periodontal health and glucose metabolism during pregnancy.PLAIN LANGUAGE SUMMARYThe relationship between periodontitis severity and gestational diabetes mellitus (GDM) risk has not been systematically characterized, and the biological mechanisms underlying this association are not clear. Our study demonstrated a significant, dose-dependent association between periodontal disease severity and GDM risk, with a 3-fold increased likelihood among pregnant women with stages II-IV periodontitis compared to healthy controls. Notably, this association was markedly stronger among women aged ≥ 30 years. Systemic inflammation may partially mediate this association, suggesting a biological link between periodontal health and glucose metabolism during pregnancy.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"110 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of senescence-associated gene expression levels in human gingival tissue affected by periodontitis.","authors":"Su Jung Kim,Chandni Batra,Hiroki Yoshii,Yusuke Hamada,Yasuyoshi Ueki,George J Eckert,Vanchit John,Mizuho Kittaka","doi":"10.1002/jper.11393","DOIUrl":"https://doi.org/10.1002/jper.11393","url":null,"abstract":"BACKGROUNDAccumulation of senescent cells is increasingly recognized as a mechanism of aging and is considered an attractive therapeutic target for various age-associated diseases. The prevalence and severity of periodontitis increase with age, and preclinical studies have demonstrated that senescent cells could be a potential therapeutic target for age-associated periodontitis. However, clinical data linking cellular senescence and periodontitis are limited.METHODSGingival tissues affected with periodontitis and healthy controls were collected from patients with or without periodontitis in a cross-sectional study. RNA isolated from these samples was analyzed for senescence gene expression by quantitative polymerase chain reaction (qPCR) assays. The associations of the gene expression levels with periodontal diagnosis, presence or absence of attachment loss or bleeding on probing, and age were examined. Additionally, we analyzed the expression of senescence genes in the gingival tissues of mice with or without ligature-induced periodontitis.RESULTSA total of 54 human gingival tissue samples were included in the study. Among the genes analyzed, p16, TP53, MMP2, and MMP14 exhibited significantly higher expression in the periodontitis group compared to the control group. Furthermore, these genes were associated with clinical signs of periodontitis, such as bleeding score and attachment loss at diagnosis. There were no statistically significant positive correlations between gene expression levels and age. The ligature-induced periodontitis significantly increased expression levels of p16 and other senescence genes in mouse gingival tissues.CONCLUSIONGene expression analysis indicates the accumulation of senescent cells in gingival tissue affected with periodontitis, supporting the concept that senotherapeutics could be effective in treating periodontitis.PLAIN LANGUAGE SUMMARYBiological stressors cause cells to age, known as cellular senescence. These senescent cells play a significant role in age-related diseases and are considered a key target for treatment. Periodontitis, a gum disease, damages the tissues that support teeth and is a leading cause of tooth loss worldwide. When people get older, they have a higher chance of being affected by periodontitis. Studies using animal models have shown that the accumulation of senescent cells may be driving periodontitis in older individuals. Therefore, targeting senescent cells may be a potential treatment approach for periodontitis. However, clinical evidence showing the accumulation of senescent cells in gum tissue affected with periodontitis is limited. This study aimed to investigate whether periodontitis is accompanied by senescent cell accumulation in the gum tissue by examining gene expression in tissues with and without periodontitis. A total of 54 human gum tissues (27 healthy and 27 diseased) were collected during gum surgeries. Our analysis found that four genes related to cellular senescence (","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"6 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between periodontitis, tooth loss, and metabolic syndrome indicators","authors":"Verbênia Silva Conceição, Isaac Suzart Gomes‐Filho, Simone Seixas da Cruz, Michelle Santana Xavier Ramos, Ana Claudia Morais Godoy Figueiredo, Soraya Castro Trindade, Daiane Silva Sampaio, Maria Clara Azevedo Moreira, Eneida de Moraes Marcílio Cerqueira, Josicélia Estrela Tuy Batista, Alexandre Marcelo Hintz, Gregory John Seymour, Frank Andrew Scannapieco, Peter Michael Loomer, Johelle de Santana Passos‐Soares","doi":"10.1002/jper.70022","DOIUrl":"https://doi.org/10.1002/jper.70022","url":null,"abstract":"BackgroundThis study investigates how poor oral health impacts metabolic alterations, specifically evaluating the effects of periodontitis and tooth loss, either individually or in combination, on the number of metabolic syndrome (MetS) indicators.MethodsA cross‐sectional study was conducted with 1281 individuals aged 18 and older, attending public health clinics. Physical exams and laboratory tests were performed to diagnose and determine MetS indicators as defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP‐ATP III) and the Joint Interim Statement (JIS). Oral exams assessed tooth loss and periodontitis severity. Multinomial regression analysis was used, and adjusted prevalence ratios (PR<jats:sub>adjusted</jats:sub>) with 95% confidence intervals (95%CI) were calculated.ResultsMetS prevalence ranged 32.3–40.7%. Periodontitis distribution was no (<jats:italic>n</jats:italic> = 202), mild (stage I; <jats:italic>n</jats:italic> = 7), moderate (stage II; <jats:italic>n</jats:italic> = 649), severe (stage III/IV; <jats:italic>n</jats:italic> = 412). Multinomial regression models revealed that periodontitis occurrence and severity, along with tooth loss, were independently associated with MetS, with stronger associations in individuals with 4 to 5 negative metabolic indicators (PR<jats:sub>adjusted</jats:sub> for periodontitis = 2,09; [95%CI:1.20–3.67]; PR<jats:sub>adjusted</jats:sub> for severe periodontitis = 2.11; [95%CI:1.04–4.29]; PR<jats:sub>adjusted</jats:sub> for tooth loss = 2.13; [95%CI:1.38–3.28]). The combined effect of periodontitis and tooth loss significantly increased the likelihood of having 4 to 5 MetS indicators (PR<jats:sub>adjusted</jats:sub> = 3.59; [95%CI:1.47–8.78]; PR<jats:sub>adjusted</jats:sub> = 5.58; [95%CI:2.45–12.75] for NCEP‐ATP III and JIS criteria, respectively).ConclusionsPeriodontitis and tooth loss are positively associated with MetS, with stronger associations observed in individuals with more severe metabolic alterations. The combined presence of these oral conditions increases the likelihood of greater metabolic impairment.Plain Language SummaryThis study examines the impact of poor oral health on metabolic syndrome (MetS). It finds that both periodontitis and tooth loss are associated with a higher number of MetS indicators. These associations are particularly stronger in individuals with more severe metabolic alterations. Additionally, individuals with both periodontitis and tooth loss are more likely to exhibit metabolic dysfunctions, including hypertension, hyperglycemia, obesity, and dyslipidemia. This highlights the critical need for integrated care addressing both periodontal and metabolic health in clinical practice.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"13 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arg‐gingipain, myeloperoxidase, and anti‐CarP across the rheumatoid arthritis spectrum","authors":"Maliha Shahbaz, Anis Rageh Al‐Maleki, Chia Wei Cheah, Jazli Aziz, Karuthan Chinna, Peter Mark Bartold, Rathna Devi Vaithilingam","doi":"10.1002/jper.70009","DOIUrl":"https://doi.org/10.1002/jper.70009","url":null,"abstract":"BackgroundThe association between periodontitis (PD) and rheumatoid arthritis (RA) has been linked to autoantibodies. In recent years, Arg‐gingipain (Rgp) triggered myeloperoxidase (MPO) release, which mediates protein carbamylation to form anti‐carbamylated proteins (anti‐CarP), perpetuating RA progression has gained interest. This study assessed the association between Rgp with MPO and anti‐CarP in pre‐clinical RA (preRA), early RA (eRA), and established RA (RA) participants with PD.MethodsA total of 108 participants were categorized into preRA, eRA, RA, and nonRA controls with and without PD. Periodontal and rheumatological parameters were assessed. &lt;jats:italic&gt;Rgp‐B&lt;/jats:italic&gt; gene expression from subgingival plaque and MPO and anti‐CarP in saliva and serum were assessed. Data were analyzed with SPSS Version 26.Results&lt;jats:italic&gt;Rgp‐B&lt;/jats:italic&gt; gene expressions were similar across PD groups. In eRA‐PD, serum and saliva MPO and saliva anti‐CarP levels were highest; strong correlations were present between &lt;jats:italic&gt;rgp‐B&lt;/jats:italic&gt; with clinical attachment loss (CAL) (&lt;jats:italic&gt;r&lt;/jats:italic&gt; = 0.783), salivary MPO with visible plaque index (VPI) (&lt;jats:italic&gt;r&lt;/jats:italic&gt; = 0.667), and gingival bleeding index (GBI) (&lt;jats:italic&gt;r&lt;/jats:italic&gt; = 0.767), and salivary anti‐CarP with CAL (&lt;jats:italic&gt;r&lt;/jats:italic&gt; = 0.667) and GBI (&lt;jats:italic&gt;r&lt;/jats:italic&gt; = 0.850). Strong positive correlations were detected between salivary MPO and anti‐CarP in preRA‐PD (&lt;jats:italic&gt;r&lt;/jats:italic&gt; = 0.903), eRA‐PD (&lt;jats:italic&gt;r &lt;/jats:italic&gt;= 0.783), RA‐PD (&lt;jats:italic&gt;r&lt;/jats:italic&gt; = 0.726), and nonRA‐PD (&lt;jats:italic&gt;r &lt;/jats:italic&gt;= 0.470).Conclusion&lt;jats:italic&gt;Rgp‐B&lt;/jats:italic&gt; gene expression was associated with PD status. Periodontal inflammation, particularly in early RA, was linked to elevated MPO and anti‐CarP levels, suggesting that local inflammation may amplify immune responses via MPO‐mediated carbamylation. These associations highlight the clinical relevance of periodontal assessment and management in RA patients and at‐risk individuals.Plain Language SummaryPeriodontitis (PD) and rheumatoid arthritis (RA) are chronic inflammatory diseases that may be linked through immune system activity. Studies suggest RA can begin developing before symptoms appear (preRA), with early immune changes occurring in the body. One possible trigger is the occurrence of myeloperoxidase (MPO)‐mediated carbamylation in the inflamed periodontium during the earliest phases of RA, which may precede the occurrence of autoantibodies, particularly anti‐carbamylated proteins (anti‐CarP). To date, these changes due to PD at different stages of RA have not been studied. This study investigated whether the &lt;jats:italic&gt;Porphyromonas gingivalis&lt;/jats:italic&gt; enzyme, Arg‐gingipain (Rgp) is linked to MPO and anti‐CarP levels in individuals at different stages of RA. A total of 108 participants were recruited for this study, including preRA,","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"3 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary microbiota and clinical periodontal measures predicting cardiometabolic disease mortality: A nationwide survey","authors":"Hamdi S. Adam, Weihua Guan, Abigail J. Johnson, Sanaz Sedaghat, Charlene Goh, James S. Pankow, Ryan T. Demmer","doi":"10.1002/jper.11395","DOIUrl":"https://doi.org/10.1002/jper.11395","url":null,"abstract":"BackgroundAlthough periodontitis and oral microbiota are linked to cardiometabolic diseases (CMD), it is unclear if they similarly predict CMD mortality. We compared the predictive ability of salivary microbiota and periodontal disease measures for CMD mortality in the National Health and Nutrition Examination Survey (NHANES).MethodsWe included 5,037 adults aged ≥30 years (mean age [± standard deviation (SD)]: 48[± 14]; 50% male) from the 2009–2010 and 2011–2012 NHANES cycles. We used 16S rRNA sequencing data from saliva to operationalize microbial composition and diversity. We calculated the relative abundance log‐ratio of <jats:italic>Treponema</jats:italic> (linked with periodontal disease) to <jats:italic>Corynebacterium</jats:italic> (linked with periodontal health) to compute the Microbial Indicator of Periodontitis (MIP). Interproximal periodontal probing depth and clinical attachment loss were measured from periodontal examinations. Mortality was ascertained through 2019. Survey‐weighted Cox models regressed mortality rates on MIP, microbial diversity, and periodontal measures to estimate hazard ratios and 95% confidence intervals (HR [95% CI]).ResultsOver 8.8 median follow‐up years, there were 81 CMD and 267 all‐cause deaths. After multivariable adjustment, MIP was associated with increased CMD mortality risk (HR per 1‐SD: 2.10 [1.30–3.38]). Neither microbial diversity nor periodontitis measures were associated with CMD mortality. MIP was associated with periodontitis in multivariable modeling (risk ratio per 1‐SD: 1.29 [1.22–1.39]).ConclusionsIn a nationally representative cohort, greater baseline salivary <jats:italic>Treponema</jats:italic> to <jats:italic>Corynebacterium</jats:italic> ratio predicted increased CMD mortality risk, while microbial diversity metrics and periodontal parameters were not significantly associated with CMD mortality. Longitudinal studies that further contextualize the oral microbiota are warranted.Plain Language SummaryBacteria in the mouth that cause gum disease are linked to cardiometabolic diseases (e.g., diabetes, cardiovascular disease, kidney disease). However, it is not well understood if bacteria of the mouth can predict the risk of death due to cardiometabolic diseases. We used data from a nationwide survey of US adults to explore whether bacteria from saliva, collected from a single time point, are associated with the future risk of cardiometabolic disease death. We found that people with higher levels of gum disease bacteria were more likely to die from cardiometabolic diseases. Future studies are needed to better understand the role of gum disease bacteria in the development of cardiometabolic diseases and the risk of death.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"2 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-implant hypoxia as a potential barrier against ferroptotic mechanisms during peri-implant diseases: A cross-sectional study.","authors":"Büşra Yılmaz,Ali Gürkan,Beral Afacan,Harika Atmaca,Timur Köse,Gülnur Emingil","doi":"10.1002/jper.70001","DOIUrl":"https://doi.org/10.1002/jper.70001","url":null,"abstract":"BACKGROUNDHypoxia modulates inflammation and oxidative stress through hypoxia-inducible factor-1α (HIF-1α). Ferroptosis, an iron-dependent cell death process, is regulated by glutathione peroxidase-4 (GPX4) and involves lipid peroxidation markers like malondialdehyde (MDA). This study evaluates HIF-1α, GPX4, and MDA levels in peri-implant crevicular fluid (PICF) across peri-implant health, mucositis, and peri-implantitis.METHODSPICF samples were collected from 62 implants of 45 participants categorized into peri-implant health (PH), mucositis (PM), and peri-implantitis (PP) groups. Enzyme-linked immunosorbent assay (ELISA) quantified HIF-1α, GPX4, and MDA levels. Statistical analyses, including Kruskal-Wallis and Spearman correlation, assessed biomarker differences and associations.RESULTSTotal MDA levels were significantly lower in PM and PP compared to PH (p = 0.014, p = 0.046). GPX4 levels were elevated in PM compared to PH (p = 0.034) but lower in PP than in PM (p < 0.001). While HIF-1α levels did not significantly differ among groups, their concentrations were notably higher in PH. A significant positive correlation was found between the total amounts of HIF-1𝛼 and GPX4 (r = 0.460, p < 0.01).CONCLUSIONOur findings demonstrated increased GPX4 and decreased MDA levels in peri-implant mucositis and peri-implantitis compared to peri-implant health, suggesting that ferroptosis may be inhibited in the peri-implant environment. Moreover, the positive correlation between HIF-1α and GPX4 levels indicates a potential regulatory role of hypoxia in modulating ferroptotic pathways in peri-implant tissues.PLAIN LANGUAGE SUMMARYBone loss around dental implants can lead to serious problems, putting the success of these implants at risk. Understanding how these issues develop is key to preventing and treating them. In the human body, cells can sometimes get damaged and die due to iron and stress caused by harmful molecules. This process, called \"ferroptosis,\" has recently gained attention in oral health research. Our study looked at whether low oxygen levels around dental implants might affect this process. We collected fluid samples from 45 people and measured 3 important substances linked to cell health and stress. We found that in diseased areas, the levels of molecules showing cell damage were lower, while the levels of substances that help protect cells were higher. This suggests that low oxygen conditions might actually help protect tissues around dental implants by preventing cell damage. These insights could help guide better ways to prevent and treat problems related to dental implants in the future.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"6 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From primary to secondary care level: Assessing patient retention of periodontal staging and grading information.","authors":"Pasquale Santamaria,Rohan Mangalpara,Thamara Kumar,Tina Lipovec,Luigi Nibali","doi":"10.1002/jper.70008","DOIUrl":"https://doi.org/10.1002/jper.70008","url":null,"abstract":"BACKGROUNDAccurate communication of periodontal stage and grade by general dentists in primary care is critical for patient understanding and engagement, yet patient retention and self-reporting of this information upon referral to secondary care remains unclear.METHODSA total of 372 periodontal patients referred were informed about their diagnosis by their general dentists and then referred to secondary care level. Data were collected through an eight-item periodontal staging and grading (PSG) questionnaire, along with demographic, medical, and dental records. Periodontal diagnoses were classified by a specialist using the 2018 classification system. Associations between clinical diagnosis and patient perception were analyzed using Chi-square tests and Spearman's rank correlation.RESULTSWhile 46.9% of patients diagnosed with periodontitis reported to be informed of their condition, only 19.3% reported knowing their specific stage and grade. Among patients with advanced periodontitis (stage III/IV), self-reported severity often aligned with clinical staging. However, for early-stage disease (stage I/II), perceptions were less accurate, and only 30.2% of grade C patients recognized rapid progression. Significant correlations were found between patient-reported symptoms and clinician-assigned staging: tooth loss (ρ = 0.69, p < 0.0001), root exposure (ρ = 0.638, p < 0.0001), and tooth mobility (ρ = 0.55, p < 0.0001).CONCLUSIONMost patients referred to secondary care lacked information on their disease stage and grade. Severe stages and grades were better perceived by patients compared with mild forms of periodontitis. The PSG questionnaire offers a valuable tool for identifying knowledge gaps and guiding tailored discussions in clinical practice.PLAIN LANGUAGE SUMMARYOur study asked 372 people referred for gum disease to fill out a simple eight-question survey about how they see their own gum health and compared their answers to the detailed diagnosis made by periodontists. We found that fewer than one in five patients knew exactly how severe their disease was or how fast it was progressing. People with more advanced gum damage generally understood their condition, but those with mild disease often thought they were healthier than they really were. When patients reported losing teeth, seeing root surfaces, or noticing loose teeth, these experiences matched closely with the clinical measures of disease severity. These results show that many patients lack clear information about their gum health and that a brief questionnaire can help dentists pinpoint misunderstandings, improve patient education, and support better treatment decisions.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"100 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis.","authors":"Átila V V Nobre,Pedro H F Silva,Marina C G Del-Arco,Raquel F Gerlach,Rene S Oliezer,José E Tanus-Santos,Luciene C Figueiredo,Janaina S A M Evangelista,Flávia A C Furlaneto,Michel R Messora,Sérgio Luiz Salvador","doi":"10.1002/jper.11389","DOIUrl":"https://doi.org/10.1002/jper.11389","url":null,"abstract":"BACKGROUNDBifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) is a probiotic bacterial strain with immunomodulatory properties. Its benefits have been observed in healthy and systemically compromised animals with periodontitis (PD). Our objective was to investigate the local and systemic effects of the systemic administration of B. lactis in pregnant rats with experimental periodontitis (EP).METHODSFor this, 48 pregnant rats were divided into four different groups (n = 12/group): Control (C), Probiotic (PROB), Periodontitis (PD), and Periodontitis + Probiotic (PD-PROB). EP was induced using a mixed model of cotton ligature placement and oral gavage of Porphyromonas gingivalis W83. On gestational day 19, the animals were euthanized for sample collection and analysis. Jaws, kidneys, and urine samples were collected for microtomographic, histological, histomorphometric, and biochemical analyses. The data were statistically analyzed (p &lt; 0.05) using nonparametric tests (Kruskal-Wallis) and analysis of variance (ANOVA) followed by Tukey and Dunn post hoc tests.RESULTSEP resulted in local and systemic damage, such as alveolar bone loss (ABL) and kidney damage, and the consumption of B. lactis HN019 resulted in improvements in these parameters. Regarding mandibular analyses, the PD-PROB group showed greater bone volume in the furcation region, a greater number and thickness of bone trabeculae, and less bone porosity and separation between trabeculae compared to the PD group (p &lt; 0.05). Regarding kidney analysis, the PD-PROB group showed lower glomerular and Bowman's capsule diameters and circumferences compared to the PD group (p &lt; 0.05).CONCLUSIONProbiotic consumption reduced damage in mandibular bone and kidney tissues in pregnant rats with EP.PLAIN LANGUAGE SUMMARYPeriodontitis (PD) is a destructive periodontal disease that can lead to tooth loss. The treatment for PD consists of scaling and root planing to remove calculus and plaque deposits; however, some systemic conditions make it difficult to control this disease. Probiotic bacteria have emerged as adjuvants in the treatment of infectious diseases, and their benefits have been demonstrated in the management of PD. The aims of the present study were to evaluate whether PD has a negative impact on pregnancy and whether the probiotic strain Bifidobacterium animalis subsp. lactis HN019 can reduce this impact. For this purpose, 48 pregnant rats were divided into four experimental groups (Control, Probiotic, PD, and PD + Probiotic), and samples of maternal and pup weights, as well as placentas, mandibles, urine, and kidneys, were collected and analyzed. We observed that PD negatively impacted pregnant rats, resulting in greater alveolar bone loss, increased expression of proteinuria and creatinine in urine, and kidney damage; systemic probiotic administration reduced these harmful effects. In addition, pups, as well as mothers supplemented with probiotic, exhibited higher weights and larger","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"18 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis and high phosphate intake alone or in combination adversely affect the kidney.","authors":"Ae Ri Kim,Min Seo Kim,Jiwon Seo,Eun-Jung Bak,Yun-Jung Yoo","doi":"10.1002/jper.70013","DOIUrl":"https://doi.org/10.1002/jper.70013","url":null,"abstract":"BACKGROUNDPeriodontitis and high phosphate (HP) intake can negatively affect the kidney in the presence of renal disease. This study aimed to evaluate the effects of periodontitis or HP intake, either alone or concurrently, on the periodontal tissue and the kidney under normal renal conditions.METHODSRats were divided into normal diet (C), HP diet (HP), tooth ligation and normal diet (P), and tooth ligation and HP diet (P+HP) groups. The mandibular first molars were ligated, and a 0.9% HP diet was provided for 12 weeks from the day of ligation. An additional group (P+HP+IFX) was administered infliximab (IFX), a tumor necrosis factor-alpha (TNF-α) inhibitor, weekly to evaluate the TNF-α inhibitory effect.RESULTSAlveolar bone loss and periodontal inflammation did not differ between the P and P+HP groups or between the C and HP groups. In the kidney, interstitial fibrosis and Col1a1 expression increased in the HP group, and ED1 expression increased in the P group, compared to the C group. Tubular basophilia, interstitial fibrosis, and the expression of Col1a1 and ED1 increased in the P+HP group compared to the other groups. The P+HP+IFX group showed a decrease in periodontal inflammation and these renal alterations compared to the P+HP group.CONCLUSIONRegardless of periodontitis, 0.9% HP intake did not affect periodontal tissue. Renal fibrosis and macrophage infiltration induced by HP intake and periodontitis, respectively, worsened when combined, indicating a synergistic adverse effect. These changes were reversed by IFX, suggesting that TNF-α inhibition may alleviate renal injury caused by periodontitis and HP intake.PLAIN LANGUAGE SUMMARYOur study examined the impact of periodontitis and a 0.9% high phosphate (HP) diet, individually and together, on periodontal tissue and kidney. We divided rats into 4 groups: normal diet, HP diet, periodontitis with a normal diet, and periodontitis with an HP diet, and assessed various periodontal and renal parameters. Although we did not observe any effects of HP intake on periodontal tissue, we found that HP intake worsened kidney health by increasing fibrosis, while periodontitis did so by increasing macrophage infiltration. Combined, these conditions worsen kidney health more than when each condition exists alone, causing more tubular basophilia, fibrosis, and macrophage infiltration. However, these negative effects were reversed with TNF-α inhibition. These findings indicate that the combination of periodontitis and HP intake exacerbates renal damage, which can be ameliorated by TNF-α inhibition.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"1 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}