Journal of periodontology最新文献

{"title":"Balint Orban Memorial Program Abstracts","authors":"","doi":"10.1002/jper.25-0080","DOIUrl":"https://doi.org/10.1002/jper.25-0080","url":null,"abstract":"","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"70 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of disrupted circadian rhythms with self‐reported periodontal diseases: Insights from 94,305 UK biobank participants","authors":"Dongyun Wang, Yanling Wei, Qi Xiang, Hongyu Yang, Ying Shan","doi":"10.1002/jper.11388","DOIUrl":"https://doi.org/10.1002/jper.11388","url":null,"abstract":"BackgroundThis study investigates the association of circadian rhythmicity, physical activity, and chronotype with periodontal diseases, focusing on both the independent and combined effects.MethodsA cross‐sectional study was conducted among 94,305 participants from the UK Biobank. Circadian rhythmicity, measured by relative amplitude from the accelerometer, was the primary exposure, with physical activity and chronotype (morning/evening preference) as secondary exposures. Self‐reported periodontal diseases were the outcome of interest. Multivariable logistic regression and restricted cubic splines were used to evaluate linear and nonlinear associations, including interactions between exposures.ResultsEach standard deviation increase in relative amplitude was associated with a 3% lower risk of periodontal diseases (odds ratio, OR: 0.97, 95% confidence interval, CI: 0.95–0.99). A 10 milligravity increase in physical activity was associated with a 10% reduction in risk (OR: 0.90, 95% CI: 0.87–0.92). An evening chronotype increased the risk by 23% (OR: 1.23, 95% CI: 1.15–1.32). Both additive and multiplicative interactions were observed between physical activity and chronotype, as evidenced by the relative excess risk due to interaction (RERI) and attributable proportion (AP), with confidence intervals excluded the null, and a synergistic effect on the multiplicative scale (OR: 1.13, 95% CI: 1.03–1.24). A nonlinear association between physical activity and periodontal diseases was observed.ConclusionsDisrupted circadian rhythms, lower physical activity, and an evening chronotype are independently and interactively associated with an elevated risk of periodontal disease. Interventions promoting circadian alignment and increasing physical activity may represent promising strategies to explore in future studies aiming to reduce periodontal risk.Plain Language SummaryModern life, with long hours and shift work, can disrupt our natural daily body clocks. This study looked at whether these disrupted rhythms, along with how much we move and whether we are “morning people” or “night owls”, affect oral health. Using wearable devices worn by over 94,000 UK adults, researchers found that people with smaller differences in activity between their most active and least active times of day had a higher risk of periodontal disease. Being more physically active was strongly associated with a lower risk, while people who naturally preferred being active later in the day (“night owls”) had a higher risk. Importantly, the combination of being a “night owl” and having low physical activity posed the greatest risk, higher than just adding the two risks together. This suggests that keeping a regular daily activity pattern (being more active during the day and less at night), getting enough exercise, and perhaps trying to lean towards a morning routine could all be important ways to maintain oral health. While more research is needed, especially to see if changing these ha","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"50 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volume‐stable collagen matrix to treat gingival recession associated with non‐carious cervical lesions: Randomized clinical trial","authors":"Mauro Pedrine Santamaria, Manuela Maria Viana Miguel, Amanda Rossato, Ana Carolina Ferreira Bonafé, Isabel Vasconcellos de Souza, Thiago Marchi Martins, Marcelo Pereira Nunes, Ingrid Fernandes Mathias‐Santamaria","doi":"10.1002/jper.11386","DOIUrl":"https://doi.org/10.1002/jper.11386","url":null,"abstract":"BackgroundCollagen matrices (CMs) have been used for the treatment of gingival recession defects. A new volume‐stable collagen matrix (VCMX) was developed focused on enhancing tissue thickness due to a cross‐linked collagen structure. Thus, the present randomized clinical trial aims to evaluate clinical and patient‐centered parameters in the treatment of gingival recession (GR) RT1 associated with non‐carious cervical lesions (NCCL) B+ partially restored using coronally advanced flap (CAF) alone or CAF and VCMX.MethodsForty patients diagnosed with GR RT1 plus NCCL B+ were treated with partial restorations (composite apical margin 1 mm beyond the estimated level cement–enamel junction), followed by CAF alone or with VCMX. Clinical, patient‐related outcomes and esthetic measurements were assessed after 6 months. The recession reduction (RecRed) was the primary outcome.ResultsCAF and CAF+VCMX provided significant RecRed (1.87 vs. 1.78 mm; <jats:italic>p</jats:italic> = 0.76) and combined defect coverage (%CDC: 50.95 vs. 48.64%, <jats:italic>p</jats:italic> = 0.60) after 6 months. No difference was observed regarding the estimated root coverage (73.54 vs. 69.65%, <jats:italic>p</jats:italic> = 0.75). Greater gingival thickness (GT) gain was observed with VCMX (0.43 vs. 0.15 mm, <jats:italic>p</jats:italic> = 0.003). Both treatments decreased dentin hypersensitivity, achieved aesthetic satisfaction, and provided similar patient comfort. Keratinized tissue width is an important predictor for root coverage success while VCMX depends on it for greater RecRed (β = 1.775; <jats:italic>p</jats:italic> = 0.004). Combined defect (CD) height and depth can have both positive and negative impacts on coverage parameters.ConclusionsBoth therapies provided significant CD coverage and RecRed, with no superiority of CAF+VCMX over CAF. However, VCMX led to a higher GT gain after 6 months (NCT05916716; IRB:46852621.0.0000.0077).Plain Language SummaryCombined defects (CDs), where gingival recession (GR) is associated with non‐carious cervical lesions (NCCL), represent a clinical condition that clinicians frequently encounter. The lack of treatment worsens dentin hypersensitivity (DH) and esthetic perceptions. Some CDs require a surgical‐restorative protocol. To date, partial restorative fillings combined with a coronally advanced flap (CAF), and connective tissue graft (CTG) surgical technique is considered the most predictable approach; however, the use of CTG has some drawbacks, including the risk of bleeding and patient discomfort. The use of collagen matrices (CMs) as an alternative to CTG has been assessed in the literature. This study aimed to evaluate a cross‐linked collagen matrix (VCMX) in the treatment of GR/RT1 associated with NCCL/B+ partially restored. Despite similar recession reduction and combined defect coverage of up to 6 months, the VCMX promoted a greater increase in gingival thickness (GT) (0.43 mm). This is a crucial parameter for maintaining long‐","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"49 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between periodontal parameters and thyroid markers in autoimmune hypothyroidism: A cross‐sectional study","authors":"Sunitha Puthiyapurayil, Rosamma Joseph Vadakkekuttical, Thulaseedharan Nallaveettil Kesavan, Harikumar Kanakkath","doi":"10.1002/jper.24-0735","DOIUrl":"https://doi.org/10.1002/jper.24-0735","url":null,"abstract":"BackgroundInflammatory cytokines play a significant role in the pathogenesis of both autoimmune hypothyroidism and periodontal disease. The cumulative effect of these inflammatory markers may lead to extensive periodontal breakdown. This study was undertaken to assess the prevalence and severity of periodontitis, to correlate clinical attachment loss (CAL), and periodontal inflamed surface area (PISA) with anti‐thyroid peroxidase (anti‐TPO) antibody, triiodothyronine (T3), thyroxine (T4), thyroid‐ stimulating hormone (TSH), and C‐reactive protein (CRP) in autoimmune hypothyroid patients and systemically healthy subjects.MethodsThis cross‐sectional study comprised of 65 autoimmune hypothyroid patients under treatment and 75 systemically healthy subjects. All participants were evaluated for periodontal parameters (bleeding on probing (BoP), probing pocket depth (PPD), CAL, oral hygiene index‐simplified (OHI‐S Index), Plaque Index (PI) and PISA) and systemic parameters (T3, T4, TSH, anti‐TPO antibody, and CRP). Analysis of quantitative and qualitative data was done by unpaired <jats:italic>t</jats:italic>‐test and Chi‐Square test, respectively.ResultsPrevalence and severity of periodontitis in the autoimmune hypothyroid group were significantly higher compared with the systemically healthy group (<jats:italic>p</jats:italic> &lt; 0.001). CAL, PISA, T3, TSH, and anti‐TPO antibody were significantly higher in the autoimmune hypothyroid group as compared with the systemically healthy group. Mean CAL and PISA were positively correlated with anti‐TPO antibody, T3, T4, TSH, and CRP. The multivariate linear regression model with dependent variable mean CAL showed that anti‐TPO antibody was significantly associated with mean CAL (<jats:italic>β</jats:italic> = 0.001, <jats:italic>p </jats:italic>= 0.02).ConclusionsAutoimmune hypothyroid subjects exhibited a higher prevalence and severity of periodontitis compared with the systemically healthy group. BoP, PPD, CAL and PISA were also higher in autoimmune hypothyroid group as compared with the systemically healthy group. A statistically significant positive correlation of CAL, and PISA with anti‐TPO antibody, T3, TSH, and CRP was observed.Plain language summaryThis study assessed the link between autoimmune hypothyroidism (a condition characterized by decreased thyroid function) and periodontitis by comparing 65 individuals with autoimmune hypothyroidism undergoing treatment to 75 healthy subjects. This research measured periodontal health indicators, thyroid hormone levels, and inflammatory markers. Results indicated that those with autoimmune hypothyroidism experienced more severe periodontal disease and increased periodontal tissue loss. They also showed elevated levels of specific thyroid antibodies and thyroid hormonal imbalances. Importantly, a significant positive association was found between the extent of periodontal tissue loss and these thyroid‐related markers, especially the anti‐TPO antibody. In c","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"20 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis in patients with severe erectile dysfunction undergoing penile prosthesis implantation: Clinical and immunohistochemical study.","authors":"Miguel Ángel Arrabal-Polo, Ana López-Toruño, Antonio Magan-Fernández, Miguel Arrabal Martin, Natividad Martín-Morales, Eva Rosel, Manuel Bravo, Francisco O Valle, Francisco Mesa","doi":"10.1002/jper.11391","DOIUrl":"https://doi.org/10.1002/jper.11391","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The relationship between periodontitis and erectile dysfunction (ED) has been poorly documented in Caucasian populations, particularly severe ED (SED) requiring penile prostheses. This study aimed to evaluate the association between periodontitis and SED in patients undergoing penile prosthesis implantation, and to identify clinical and biochemical periodontal variables associated with SED using multivariate analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An observational case-control study was conducted on patients with SED (cases) and patients with other conditions, such as penile curvature and Peyronie's disease (controls). Periodontal clinical and biochemical variables were assessed, alongside histomorphometrical and immunohistochemical analyses of corporotomies from the corpora cavernosa.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study included 81 patients: 24 with SED and 57 controls. Compared to controls, the SED group showed higher age (p &lt; 0.001), lower high density lipoproteins (HDL) levels (p = 0.012), higher diabetes prevalence (p = 0.036), fewer teeth (p &lt; 0.001), more sites with attachment loss &gt; 3 mm (p = 0.014), and over 3 times greater Periodontal Inflammatory Severity Index modified (PISIM) (p &lt; 0.001). Additionally, the SED group had fewer blood vessels/mm&lt;sup&gt;2&lt;/sup&gt; (p &lt; 0.001) and lower endothelial nitric oxide synthase (eNOS) expression (p = 0.043). Multivariate logistic regression showed that age &gt; 55 years (odds ratio [OR] = 5.9, 95% confidence interval [CI] 1.5-22.9, p = 0.010), diabetes (OR = 7.0, 95%CI 1.3-37.9 p = 0.023), and PISIM scores &gt; 4 (OR = 13.9, CI 2.6-73.8, p = 0.002) increased the likelihood of SED requiring prothesis implantation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Periodontitis is strongly associated with SED treated with penile prostheses, linked to lower eNOS expression in penile tissue. Diabetes and age were identified as additional independent risk factors for SED.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Erectile dysfunction (ED) is a common condition where men have trouble achieving or maintaining an erection. In severe cases, surgery to implant a penile prosthesis is sometimes needed. This study explored whether gum disease (periodontitis), a condition that damages the tissues supporting the teeth, is linked to severe erectile dysfunction (SED). We compared two groups of patients: those with SED who required a penile implant and those with other penile conditions, such as curvature. We found that men with SED were more likely to have advanced gum disease, fewer teeth, and signs of poor oral health. They also showed lower levels of certain molecules, like nitric oxide, that help blood vessels work properly, including those in the penis. Diabetes and being older than 55 also increased the likelihood of SED. Our findings suggest that gum disease may play a role in SED, possibly by affecting blood vessel health. This highlights the importance of good oral hygiene and managing","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palatal pre-suturing effects on hemostasis and morbidity in connective tissue grafting: A randomized controlled trial.","authors":"Melis Ziyaettin, Nazlı Gül Kınoğlu Canpolat, Burcu Karaduman","doi":"10.1002/jper.11392","DOIUrl":"https://doi.org/10.1002/jper.11392","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to assess the impact of palatal pre-suturing on bleeding, postoperative morbidity, wound healing, and quality of life following subepithelial connective tissue graft (SCTG) surgery through a randomized controlled clinical trial.</p><p><strong>Methods: </strong>Thirty-two healthy, non-smoking participants (18-60 years) with a single Cairo type 1 or 2 gingival recession were randomly assigned to test (n = 16) and control (n = 16) groups. Both groups underwent a coronally advanced flap with SCTG. In the test group, a greater palatal compression suture (GPCS) was applied before SCTG, while the control group did not receive GPCS. Intraoperative bleeding and surgical duration were recorded. Postoperative parameters, including bleeding, pain, analgesic use, Landry wound healing index, and Oral Health Impact Profile-14 Turkish (OHIP-14 TR) scores, were assessed on day 3, weeks 1 and 2, and months 1 and 3.</p><p><strong>Results: </strong>No significant differences in age or sex were observed (p > 0.05). The test group showed significantly lower intraoperative bleeding and shorter operation time (p < 0.05). Additionally, postoperative pain and analgesic use were significantly reduced in the test group compared with the control group at week 1 (p < 0.05). OHIP-14 TR scores were higher in the control group (p < 0.05). Landry wound healing index scores were superior in the test group on days 3, 7, and 14 (p < 0.01).</p><p><strong>Conclusions: </strong>GPCS reduces intraoperative bleeding, shortens operative time, and positively influences postoperative morbidity and wound healing. Its application in high-bleeding-risk cases or prior to extensive graft harvesting may enhance procedural predictability and provide clinicians with greater confidence in bleeding control.</p><p><strong>Plain language summary: </strong>Gingival recession is characterized by the apical displacement of the gingival margin, leading to root surface exposure and potential functional and esthetic concerns. Gingival graft surgery is a commonly performed procedure in which autogenous connective tissue is harvested from the palate and transplanted to the recession site. However, this procedure is often associated with intraoperative bleeding, postoperative discomfort, and variable healing outcomes. This study evaluated the effect of Greater Palatal Compression Suture (GPCS) application on perioperative bleeding and patient outcomes when placed before harvesting connective tissue from the palatal donor site. Thirty-two systemically healthy individuals with gingival recession were randomly assigned to two groups: one group received GPCS before graft harvesting, while the other underwent the standard procedure. The findings demonstrated that GPCS significantly reduced intraoperative bleeding, shortened surgical duration, and improved wound healing. Additionally, individuals in the GPCS group reported lower postoperative pain levels and reduced ana","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric buccal bone alterations at immediate implant sites with or without soft tissue augmentation: A 6-month assessment.","authors":"Mary Jung,Duong Tran,Chi-Ching Chang,Sung K Kim,Yosuke Tsukiboshi,Seiko Min,Srinivas Ayilavarapu,Chun-Teh Lee","doi":"10.1002/jper.11381","DOIUrl":"https://doi.org/10.1002/jper.11381","url":null,"abstract":"BACKGROUNDThis study is part of a randomized controlled trial investigating the impact of soft tissue augmentation (STA) using subepithelial connective tissue graft (SCTG) (immediate implant with subepithelial connective tissue graft [ICT] group) or acellular dermal matrix (ADM) (immediate implant with acellular dermal matrix [IAD] group) versus no STA (control) on the clinical outcomes following immediate implant placement (IIP). This study aimed to investigate volumetric buccal bone dimensional changes at immediate implant sites 6 months after the surgery.METHODSForty-five patients requiring extraction of a maxillary anterior tooth or premolar and randomly assigned to one of the three groups were included. Cone-beam computed tomography (CBCT) images were obtained prior to tooth extraction and 6 months after IIP and then superimposed to evaluate 3D (volumetric) and 2D (linear) changes in buccal bone dimensions around the implant. Measurements included three regions of interest (coronal, middle, and apical segments). The associations between clinical factors and 3D buccal bone dimensional changes were analyzed using linear regression analysis. The correlations between 3D and 2D measurements were analyzed using Pearson's correlation coefficient. Statistical significance was assessed using an alpha level of 0.05.RESULTSVolumetric bone dimensional changes were not significantly different between the groups. The greatest amount of bone loss occurred in the coronal segment (ICT: -14.99 ± 4.29 mm3; IAD: -13.60 ± 3.97 mm3; Control: -12.58 ± 4.09 mm3; p = 0.286). The thick bone morphotype was significantly associated with increased absolute volumetric bone loss (p = 0.001, 0.041, and 0.013 for coronal, middle, and apical segments, respectively). Measurements of 3D and 2D bone dimensional changes had low to high correlations (range 0.39-0.95) in different segments.CONCLUSIONSTA did not significantly affect bone dimensional loss at 6 months. Linear measurements may not fully represent volumetric bone dimensional changes at immediate implant sites.CLINICAL TRIAL REGISTRATIONThis study is part of a randomized controlled trial (RCT) registered with ClinicalTrials.gov (ID NCT02864862). The title of the trial is Esthetic Outcomes Following Immediate Implant Combined with Soft Tissue Augmentation.PLAIN LANGUAGE SUMMARYThis study investigated how soft tissue augmentation (STA) affected the changes in bone around dental implants placed immediately after tooth extraction. Specifically, it compared the use of a connective tissue graft and an acellular dermal matrix against no STA. Forty-five patients who needed a maxillary anterior tooth or premolar extraction and a dental implant were included. Before the extraction and 6 months after implant placement, cone-beam computed tomography (CBCT) scans were taken to measure changes in the bone dimensions around the implants. The analysis included three sections of the bone: the coronal, middle, and apical sections. The re","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"143 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-dependent association of systemic comorbidities with periodontitis severity: A large population cross-sectional study.","authors":"Muhammad H A Saleh,Hamoun Sabri","doi":"10.1002/jper.25-0055","DOIUrl":"https://doi.org/10.1002/jper.25-0055","url":null,"abstract":"BACKGROUNDTo examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi-center electronic health record (EHR) repository.METHODSA cross-sectional analysis was conducted using EHR data from 9 dental schools in the United States. We included 264,913 adults (≥18 years) receiving periodontal therapy between 2013 and 2023. Periodontitis severity (no, mild/moderate, severe) was determined, and out of 98 systemic and behavioural conditions, associations with 24 conditions were evaluated using weighted uni- and multi-variate multinomial logistic regressions (with no periodontitis as reference) by 2 adjusted models accounting for age, sex, smoking, and diabetes. Model fit and assumptions were checked using Akaike information criterion (AIC), likelihood ratio test (LRT), false discovery rate (FDR) -adjusted p-values, and variance inflation factor (VIF) < 10. The manuscript was prepared following the Oral Health Statistical reporting guidelines (OHStat) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.RESULTSAmong 264,913 adult patients, 166,207 had no periodontitis, and 98,706 had periodontitis. In fully adjusted models of 24 selected systemic comorbidities, the odds ratios (ORs) for severe periodontitis consistently exceeded those for mild/moderate periodontitis. For instance, smoking showed ORs of 1.78 (mild/moderate) versus 5.21 (severe), diabetes (2.20 vs. 5.59), cardiovascular disease (1.53 vs. 2.21), human immunodeficiency virus (HIV) (2.25 vs. 4.07), and Alzheimer's disease (1.84 vs. 3.20). Inverse correlations also strengthened with severity where asthma was 0.80 versus 0.72 in severe compared to mild/moderate periodontitis.CONCLUSIONSThe results of this population-based study demonstrate that as periodontitis severity escalates, positive and negative associations with systemic conditions become more pronounced.PLAIN LANGUAGE SUMMARYThis study examined how various chronic health conditions may increase the likelihood of developing more severe gum disease, also known as periodontitis. Using electronic health record data from over 260,000 adults treated at 9 U.S. dental schools, we investigated whether people with systemic diseases-like diabetes, cardiovascular disease, or human immunodeficiency virus (HIV)-were more likely to have mild or severe periodontitis. The results showed that several conditions significantly increased the odds of having more severe gum disease. For instance, individuals with diabetes or cardiovascular problems had more than double the risk of severe periodontitis, while those with HIV or dementia showed even stronger associations. Some conditions, such as asthma or anorexia, were linked to lower odds of gum disease, suggesting that these relationships may be complex and deserve further study. Although this study cannot determine cause and effect, it highlights a pattern: people with ch","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"16 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar bone configuration in mandibular first molars with disto‐lingual roots: A cross‐sectional radiographic study","authors":"Ying‐Wu Chen, Chia‐Dan Cheng, Siao‐Han Chen, Chi‐Hsiang Chung, Pei‐Wei Weng, Yu‐Ching Liu, Yi‐Wen Cathy Tsai, Cheng‐En Sung, Wan‐Chien Cheng, Ren‐Yeong Huang","doi":"10.1002/jper.11383","DOIUrl":"https://doi.org/10.1002/jper.11383","url":null,"abstract":"BackgroundPrecise assessment of anatomical variations and alveolar bone configurations (ABCs) in permanent mandibular first molars (PMFMs) is crucial for effective periodontal treatment. This cross‐sectional study aimed to evaluate the prevalence of disto‐lingual roots (DLRs) and ABCs in PMFMs and investigate the correlation between DLRs and clinical parameters related to ABCs at the distal aspect of PMFMs.MethodsA total of 572 patients (863 PMFMs) were included in the analysis. The prevalence of DLRs and ABCs (parallel [P], distal inclined [D], and mesial inclined [M] types) and their relationship with clinical parameters were investigated. Multivariable logistic regression analysis was used to identify subject‐, tooth‐, and site‐specific factors influencing the frequency of ABCs at the distal site of PMFMs.ResultsThe prevalence of DLRs was 28.32% of subjects and 24.22% of examined PMFMs. The presence of DLRs significantly altered the distribution of ABCs, with a notable increase in M type configurations at the distal sites of PMFMs (<jats:italic>p</jats:italic> &lt; 0.05). Clinical attachment loss (CAL) was significantly greater at the distal sites of PMFMs with DLRs compared with those without (<jats:italic>p</jats:italic> &lt; 0.05). Multivariable logistic regression revealed that DLRs, lingual furcation involvement, and severe CAL (≥5 mm) were significantly associated with a higher frequency of M type ABCs.ConclusionsMesial inclined (M) type ABCs were significantly higher in PMFMs with DLRs, lingual furcation involvement, and severe CAL, suggesting a notable link between DLRs and specific ABCs at distal sites of PMFMs.Plain language summaryThis study focuses on the unique anatomical structure of disto‐lingual roots (DLRs) in permanent mandibular first molars and their impact on periodontal health. The key finding(s) discovered that teeth with DLRs had a significantly higher prevalence of certain patterns of bone loss (mesial inclined configurations) at their distal sites compared with teeth without DLRs. This type of bone loss was associated with more severe clinical attachment loss and lingual furcation involvement. These findings underline the importance of recognizing DLRs as contributing factors in periodontal disease progression and highlight the need for careful diagnosis and tailored treatment strategies.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"150 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing tooth loss over 9–11 years in young individuals with periodontitis","authors":"Carolina Modin, Andreas Cederlund, Anders Gustafsson, Tülay Yucel‐Lindberg, Leif E Jansson","doi":"10.1002/jper.24-0687","DOIUrl":"https://doi.org/10.1002/jper.24-0687","url":null,"abstract":"BackgroundHerein, we aimed to identify factors associated with tooth loss over a 9‐ to 11‐year period in young individuals with periodontitis, with a specific focus on the impact of patient compliance. The secondary outcome was to identify factors associated with discontinuation of active periodontal treatment.MethodsThis retrospective register‐based cohort study included 446 patients under the age of 36, diagnosed with periodontitis at 2 periodontal clinics, between 2003 and 2009. Variables were collected from digital dental records combined with 2 national health registers. The follow‐up period was between 2009 and 2019. Negative binomial and logistic regression analyses identified factors significantly associated with tooth loss and discontinuation of periodontal treatment.ResultsThe majority of patients had lost none or maximum of 3 teeth due to periodontitis, while 3.6% had lost ≥ 10 teeth. The mean number of teeth lost due to periodontitis was 1.3 (range 0–26). Generalized periodontitis, stage IV, low level of education, smoking, and discontinuation of active periodontal treatment (APT) were significantly correlated with tooth loss. The variables periodontal stage, low level of education together with low income were correlated to discontinuation of APT.ConclusionsIn this register‐based study, discontinuation of APT, severe periodontal disease, smoking, and low level of education increased the risk for tooth loss. Additionally, low education level, low income, and severe periodontal disease were also significantly associated with discontinuation of APT.Plain Language SummaryThere are few studies focusing on tooth loss in young individuals with periodontitis. To increase knowledge on this issue, this register‐based study focused on 446 individuals who were younger than 36 years of age at time of their periodontal diagnosis. During a follow‐up period from 2009 to 2019, most individuals lost few or no teeth, while a minority accounted for most of the tooth losses. Patients with a generalized severe periodontal disease, low educational level, and who smoked were at the highest risk of tooth loss. Additionally, interruption of periodontal treatment was observed to be more common in patients with severe disease.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":"723 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}