<p>For conditions that often entail significant impairment, such as Alzheimer's disease or stroke, there is an established standard in clinical trials to adopt outcome measures that integrate function in both cognitive and physical domains, such as the Clinical Dementia Rating Scale<span><sup>1</sup></span> and the modified Rankin Scale.<span><sup>2</sup></span> What is perhaps a newer direction is adopting a similar paradigm, blending the brain and the body, within the context of prevention. Several recent trials including ASPREE (Aspirin in Reducing Events in the Elderly),<span><sup>3</sup></span> STAREE (Statins in Reducing Events in the Elderly),<span><sup>4</sup></span> and PREVENTABLE (Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults)<span><sup>5</sup></span> have adopted a primary composite outcome of survival free of dementia and disability, integrating the incidence of all-cause dementia, persistent disability in activities of daily living, and all-cause mortality. The appeal of this outcome is that it is inherently patient-centric, focused on the foundational goal of maintaining functional independence in aging populations. However, as with anything new, there are still a myriad of questions that need to be explored before adopting survival free of dementia and disability as the default outcome choice for prevention trials in older adults. Does it conform, in theory and in practice, to recommendations for adopting composite outcomes?<span><sup>6</sup></span> What interventions might be most likely to prevent both incident disability and cognitive impairment? What risk factors should one consider in trying to optimize inclusion and exclusion criteria, as well as event rates? What role does precision medicine have with such an endpoint?</p><p>In this issue of the <i>Journal of the American Geriatrics Society</i>, Clocchiatti-Tuozzo et al. begin to examine the latter two questions through the lens of genetics, evaluating the association of apolipoprotein E (<i>APOE</i>) genotypes with the incidence of dementia, disability, and all-cause mortality in the Health and Retirement Study.<span><sup>7</sup></span> Among 14,527 older adults (median age 55 years, 58% female, >70% of European ancestry, 25% carriers of at least one <i>APOE</i> ε4 allele), without dementia or disability at baseline followed for a median of 18 years, carriers of the <i>APOE</i> ε4 allele had an increased incidence of the composite outcome of incident dementia, disability, or death (adjusted hazard Ratio (aHR) = 1.15, 95% CI: 1.09–1.21), while being a carrier of the <i>APOE</i> ε2 genotype was associated with a non-statistically significant decrease in risk for that outcome (aHR = 0.94, 95% CI: 0.87–1.01). In looking at the individual components of the composite outcome, carrying the <i>APOE</i> ε4 allele was associated with increased risk of dementia and mortality, but not disability (aHR = 0.98, 95% CI: 0.89–1.08). In secondary analyses
{"title":"Precision medicine and patient-centered outcomes: Learning from APOE for prevention clinical trials in older adults","authors":"Nicholas M. Pajewski PhD","doi":"10.1111/jgs.19097","DOIUrl":"10.1111/jgs.19097","url":null,"abstract":"<p>For conditions that often entail significant impairment, such as Alzheimer's disease or stroke, there is an established standard in clinical trials to adopt outcome measures that integrate function in both cognitive and physical domains, such as the Clinical Dementia Rating Scale<span><sup>1</sup></span> and the modified Rankin Scale.<span><sup>2</sup></span> What is perhaps a newer direction is adopting a similar paradigm, blending the brain and the body, within the context of prevention. Several recent trials including ASPREE (Aspirin in Reducing Events in the Elderly),<span><sup>3</sup></span> STAREE (Statins in Reducing Events in the Elderly),<span><sup>4</sup></span> and PREVENTABLE (Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults)<span><sup>5</sup></span> have adopted a primary composite outcome of survival free of dementia and disability, integrating the incidence of all-cause dementia, persistent disability in activities of daily living, and all-cause mortality. The appeal of this outcome is that it is inherently patient-centric, focused on the foundational goal of maintaining functional independence in aging populations. However, as with anything new, there are still a myriad of questions that need to be explored before adopting survival free of dementia and disability as the default outcome choice for prevention trials in older adults. Does it conform, in theory and in practice, to recommendations for adopting composite outcomes?<span><sup>6</sup></span> What interventions might be most likely to prevent both incident disability and cognitive impairment? What risk factors should one consider in trying to optimize inclusion and exclusion criteria, as well as event rates? What role does precision medicine have with such an endpoint?</p><p>In this issue of the <i>Journal of the American Geriatrics Society</i>, Clocchiatti-Tuozzo et al. begin to examine the latter two questions through the lens of genetics, evaluating the association of apolipoprotein E (<i>APOE</i>) genotypes with the incidence of dementia, disability, and all-cause mortality in the Health and Retirement Study.<span><sup>7</sup></span> Among 14,527 older adults (median age 55 years, 58% female, >70% of European ancestry, 25% carriers of at least one <i>APOE</i> ε4 allele), without dementia or disability at baseline followed for a median of 18 years, carriers of the <i>APOE</i> ε4 allele had an increased incidence of the composite outcome of incident dementia, disability, or death (adjusted hazard Ratio (aHR) = 1.15, 95% CI: 1.09–1.21), while being a carrier of the <i>APOE</i> ε2 genotype was associated with a non-statistically significant decrease in risk for that outcome (aHR = 0.94, 95% CI: 0.87–1.01). In looking at the individual components of the composite outcome, carrying the <i>APOE</i> ε4 allele was associated with increased risk of dementia and mortality, but not disability (aHR = 0.98, 95% CI: 0.89–1.08). In secondary analyses ","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"72 10","pages":"2961-2964"},"PeriodicalIF":4.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p>Providing unscheduled, acute, and longitudinal care to older adults who are aging in place is a critical, yet largely unsolved, health system challenge. A large gap exists between the times and places where older adults need care and the resources available to address those needs.<span><sup>1</sup></span> Despite efforts to increase older adults' access to in-home care through home-based primary care, telemedicine, and workforce development, persistent gaps prompted recent calls by the American Geriatrics Society and the American Association of Geriatric Psychiatry to expand the “team based geriatric physician and health professional workforce by nontraditional means.”<span><sup>2, 3</sup></span> This creates an opportunity for innovative, multidisciplinary, patient-centered teams to bridge the gap.</p><p>Emergency medical services (EMS) agencies and clinicians are often called upon to fill this gap: they are accessible, mobile, and a trusted source of care in communities across the nation.<span><sup>4</sup></span> Though originally designed for emergency treatment and transportation of the critically ill and injured, EMS clinicians are increasingly embracing roles that span community outreach, prevention, and chronic disease management in a model of care known as “community paramedicine.”<span><sup>5</sup></span> Community paramedicine is designed to fill the space between fixed medical system resources and dynamic community needs by leveraging availability, accessibility, and versatile skills of EMS clinicians working as part of physician-led or multidisciplinary team. This model of care is of clear importance to older adults who are aging in place.</p><p><i>JAGS</i> has been at the forefront of rigorous examination of the community paramedicine model of care for older adults. As early as 1968, Mel Spear advocated for the concept of a physician-led, team-based, patient-centered approach to physical, emotional, and social well-being of older adults in “Paramedical Services for Older Adults.”<span><sup>6</sup></span> More recently, <i>JAGS</i> authors have described an array of community paramedicine programs tailored to the needs of older adults, including providing urgent, in-home, integrated evaluation and treatment to avoid unnecessary EMS transportation of medically complex older adults,<span><sup>7, 8</sup></span> facilitating the ED-to-home care transition,<span><sup>9</sup></span> using 9-1-1 calls as a sentinel event to prompt fall prevention intervention,<span><sup>10, 11</sup></span> and integrating community paramedics into home-based primary care practices to extend telehealth geriatrician reach and efficiency.<span><sup>12</sup></span> Additional program examples support the feasibility, effectiveness, and short-term health outcomes of community paramedicine for older adults.<span><sup>13-15</sup></span> However, limited data describe patient safety, process and health outcomes, and sustainable financial models for community para
{"title":"Beyond flashing lights and sirens: Community paramedicine as health safety nets for older adults","authors":"Alexander J. Ulintz MD, Carmen E. Quatman MD, PhD","doi":"10.1111/jgs.19087","DOIUrl":"10.1111/jgs.19087","url":null,"abstract":"<p>Providing unscheduled, acute, and longitudinal care to older adults who are aging in place is a critical, yet largely unsolved, health system challenge. A large gap exists between the times and places where older adults need care and the resources available to address those needs.<span><sup>1</sup></span> Despite efforts to increase older adults' access to in-home care through home-based primary care, telemedicine, and workforce development, persistent gaps prompted recent calls by the American Geriatrics Society and the American Association of Geriatric Psychiatry to expand the “team based geriatric physician and health professional workforce by nontraditional means.”<span><sup>2, 3</sup></span> This creates an opportunity for innovative, multidisciplinary, patient-centered teams to bridge the gap.</p><p>Emergency medical services (EMS) agencies and clinicians are often called upon to fill this gap: they are accessible, mobile, and a trusted source of care in communities across the nation.<span><sup>4</sup></span> Though originally designed for emergency treatment and transportation of the critically ill and injured, EMS clinicians are increasingly embracing roles that span community outreach, prevention, and chronic disease management in a model of care known as “community paramedicine.”<span><sup>5</sup></span> Community paramedicine is designed to fill the space between fixed medical system resources and dynamic community needs by leveraging availability, accessibility, and versatile skills of EMS clinicians working as part of physician-led or multidisciplinary team. This model of care is of clear importance to older adults who are aging in place.</p><p><i>JAGS</i> has been at the forefront of rigorous examination of the community paramedicine model of care for older adults. As early as 1968, Mel Spear advocated for the concept of a physician-led, team-based, patient-centered approach to physical, emotional, and social well-being of older adults in “Paramedical Services for Older Adults.”<span><sup>6</sup></span> More recently, <i>JAGS</i> authors have described an array of community paramedicine programs tailored to the needs of older adults, including providing urgent, in-home, integrated evaluation and treatment to avoid unnecessary EMS transportation of medically complex older adults,<span><sup>7, 8</sup></span> facilitating the ED-to-home care transition,<span><sup>9</sup></span> using 9-1-1 calls as a sentinel event to prompt fall prevention intervention,<span><sup>10, 11</sup></span> and integrating community paramedics into home-based primary care practices to extend telehealth geriatrician reach and efficiency.<span><sup>12</sup></span> Additional program examples support the feasibility, effectiveness, and short-term health outcomes of community paramedicine for older adults.<span><sup>13-15</sup></span> However, limited data describe patient safety, process and health outcomes, and sustainable financial models for community para","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"72 9","pages":"2640-2643"},"PeriodicalIF":4.3,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel O'Conor PhD, MPH, Andrea M. Russell PhD, Allison Pack PhD, MPH, Dianne Oladejo BA, Sarah Filec MPH, Emily Rogalski PhD, Darby Morhardt PhD, Lee A. Lindquist MD, MPH, MBA, Michael S. Wolf PhD, MPH