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A Hospice Intervention for Caregivers: Improving Home Hospice Management of End-Of-Life Symptoms (I-HoME) Pilot Study 照顾者的安宁疗护干预:改善临终症状的居家安宁疗护管理(I-HoME)试点研究。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-24 DOI: 10.1111/jgs.70113
Veerawat Phongtankuel, Sara J. Czaja, Taeyoung Park, Jerad Moxley, Ronald D. Adelman, Ritchell Dignam, Dulce M. Cruz-Oliver, Micah Denzel Toliver, M. C. Reid

Background

While home-based hospice care seeks to reduce suffering at the end of life (EoL), patients continue to experience a high symptom burden. High symptom burden contributes to adverse outcomes, including patient suffering, burdensome care transitions, and caregiver burden. Yet, most caregivers lack formal education in patient symptom management despite providing up to 65 h of care per week. Interventions that provide symptom support and education to caregivers could improve EoL outcomes for patients and caregivers.

Methods

We conducted a pilot randomized controlled trial (N = 80) in a hospice organization to assess the feasibility, acceptability, and preliminary efficacy of the Improving Home Hospice Management of End-of-life Symptoms (I-HoME) intervention. This caregiver-focused intervention aims to reduce patient symptom burden through weekly tele-visits with a nurse practitioner and caregiver educational videos to provide symptom support and education.

Results

The mean age of caregivers (N = 80) was 60.3 (standard deviation ± 12.1); with a majority being women (79%) and children of the patient (67%). In the I-HoME group (n = 40), a total of 121 of a possible 145 tele-visits (83%) were completed. Over 96% of caregivers were either satisfied or very satisfied with the tele-visits. Eighty-three percent agreed or strongly agreed that it prepared them to manage symptoms better, while 88% agreed or strongly agreed that the intervention increased their confidence in managing symptoms. The average reduction in patient symptom burden, as measured by the Edmonton Symptom Assessment Scale, for the intervention group who received all six visits was 6.6 points compared to 2.9 for the control group.

Conclusions

The I-HoME intervention was feasible to implement in the home hospice setting and acceptable to caregivers and hospice staff. Future efficacy trials are needed to determine whether this caregiver-focused intervention, which provides symptom support and education, can measurably improve patient and caregiver outcomes in the home hospice setting.

背景:虽然以家庭为基础的安宁疗护寻求减少生命末期(EoL)的痛苦,但患者仍会经历较高的症状负担。高症状负担会导致不良后果,包括患者痛苦、繁重的护理过渡和护理人员负担。然而,尽管每周提供多达65小时的护理,大多数护理人员缺乏患者症状管理方面的正规教育。向护理人员提供症状支持和教育的干预措施可以改善患者和护理人员的EoL结果。方法:我们在一家安宁疗护机构进行了一项随机对照试验(N = 80),以评估改善居家安宁疗护临终症状管理(I-HoME)干预的可行性、可接受性和初步效果。这种以护理人员为中心的干预措施旨在通过每周与执业护士进行远程访问和护理人员教育视频来提供症状支持和教育,从而减轻患者的症状负担。结果:护理人员平均年龄(N = 80)为60.3(标准差±12.1);其中大多数是女性(79%)和患者的儿童(67%)。在I-HoME组(n = 40)中,可能的145次远程就诊中总共完成了121次(83%)。超过96%的护理人员对远程就诊满意或非常满意。83%的人同意或强烈同意它使他们更好地控制症状,而88%的人同意或强烈同意干预增加了他们对控制症状的信心。根据埃德蒙顿症状评估量表(Edmonton symptom Assessment Scale)的测量,接受了所有六次就诊的干预组患者症状负担的平均减轻程度为6.6分,而对照组为2.9分。结论:I-HoME干预在居家安宁疗护环境中实施是可行的,且被照顾者和安宁疗护人员所接受。未来的疗效试验需要确定这种以照顾者为中心的干预,提供症状支持和教育,是否可以显著改善家庭安宁疗护环境中病人和照顾者的结果。
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引用次数: 0
Cover 封面
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-24 DOI: 10.1111/jgs.70101
Juliana Teruel Camargo, Jessica Otero Machuca, Amanda S. Hinerman, Erik J. Rodriquez, Christian S. Alvarez, George A. Mensah, Stephanie M. George, Frank Bandiera, Zhuochen Li, Dillon O. Sylte, Yekaterina O. Kelly, Theresa A. McHugh, Mathew M. Baumann, Michael Celone, Demewoz Haile, Wichada La Motte-Kerr, Christopher J. L. Murray, Laura Dwyer-Lindgren, Ali H. Mokdad, Eliseo J. Pérez-Stable

Cover caption: County-level estimated age-standardized protein-energy malnutrition mortality rates for individuals aged ≥ 75 by race and/or ethnic population groups, 2019, U.S. Estimates are masked (shown in white) for county and race and/or ethnicity combinations with a mean annual population <1000. See the related article by Camargo et al., pages 2868–2877.

封面说明:2019年,美国按种族和/或族裔人群划分的年龄标准化蛋白质-能量营养不良≥75岁个体的县级估计死亡率(以白色显示),平均年人口为1000。参见Camargo等人的相关文章,第2868-2877页。
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引用次数: 0
Reply to: Comment on “Tooth Loss and 12-Year Mortality Risk in 8494 Older Adults From Ireland” 回复:关于“8494名爱尔兰老年人牙齿脱落和12年死亡风险”的评论。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-24 DOI: 10.1111/jgs.70115
Lewis Winning, Brian O'Connell
<p>We thank Dr. Somay for her thoughtful commentary on our study examining the association between tooth loss and mortality risk in older Irish adults [<span>1, 2</span>]. We appreciate the opportunity to address the important methodological considerations raised.</p><p>First, regarding the exposure variable relying on self-report dental status, we acknowledge that objective clinical assessments provide more granular data than self-report measures. However, we are able to validate our exposure variable, using objective oral health assessments conducted in a subsequent wave (Wave 3) of The Irish Longitudinal Study on Ageing in a subset of 2521 participants [<span>3</span>]. As shown in Figure 1, plotting actual tooth count across our three self-report exposure categories reveals a clear stepwise pattern of decreasing tooth count. Dentate participants without dentures had a median of 24 teeth (IQR: 21–27), dentate participants with dentures had a median of 15 teeth (IQR: 9–20), and edentulous participants had a median of 0 teeth (IQR: 0–0). Although some outliers were present, they were relatively few and did not disrupt the clear monotonic pattern. The ordered self-report categories showed good monotonic association with actual tooth count (Spearman's <i>ρ</i> = −0.737; <i>p</i> < 0.001), supporting the validity of our exposure classification for large-scale epidemiological studies. Although some misclassification may exist, particularly among participants with very few remaining teeth, any such non-differential misclassification would be expected to bias estimates towards the null, rendering our reported associations conservative [<span>4</span>].</p><p>Second, regarding our decision to combine the original five response categories into three groups, this recoding was performed to enhance statistical stability and power while maintaining clinically meaningful distinctions. We acknowledge this approach may obscure some clinically relevant nuances. However, a sensitivity analysis using the original five categories (presented in Supporting Information S1 in the online version of the article [<span>2</span>]) yielded consistent results, supporting the robustness of our findings. The trend tests across categories remained significant in all models, indicating a dose-dependent response relationship in the risk for all-cause mortality.</p><p>Third, concerning potential residual confounding, we acknowledge that factors such as nutritional status, frailty, depression, and social isolation were not included in our analysis. Our models employed sequential adjustment across four stages: Model 1 (age, sex); Model 2 (education, socioeconomic status, marital status); Model 3 (smoking, alcohol, BMI); and Model 4 (diabetes, cardiovascular conditions, antihypertensive medication). Although unmeasured confounding cannot be entirely eliminated, the consistency of our findings with prior evidence and the dose–response pattern observed across dentition categories s
我们感谢Somay博士对我们研究爱尔兰老年人牙齿脱落与死亡风险之间关系的周到评论[1,2]。我们感谢有机会讨论所提出的重要方法方面的考虑。首先,关于依赖于自我报告的牙齿状况的暴露变量,我们承认客观的临床评估比自我报告的测量提供了更细粒度的数据。然而,我们能够验证我们的暴露变量,使用在爱尔兰老龄化纵向研究的下一波(第三波)中对2521名参与者进行的客观口腔健康评估[3]。如图1所示,在我们的三个自我报告暴露类别中绘制实际牙齿数量,揭示了牙齿数量逐渐减少的清晰模式。无假牙的有齿受试者中位数为24颗牙(IQR: 21-27),有假牙的有齿受试者中位数为15颗牙(IQR: 9-20),无假牙受试者中位数为0颗牙(IQR: 0 - 0)。虽然存在一些异常值,但它们相对较少,并且没有破坏明显的单调模式。有序的自我报告类别与实际牙齿数显示出良好的单调相关性(Spearman's ρ = - 0.737; p < 0.001),支持我们的暴露分类在大规模流行病学研究中的有效性。尽管可能存在一些错误分类,特别是在剩余牙齿很少的参与者中,任何这种非差异错误分类都可能使估计偏向于零,使我们报告的关联保守。其次,关于我们决定将最初的五个反应类别合并为三组,进行这种重新编码是为了增强统计稳定性和有效性,同时保持临床有意义的差异。我们承认这种方法可能会模糊一些临床相关的细微差别。然而,使用原始的五个类别(在文章b[2]的在线版本的支持信息S1中提出)的敏感性分析得出了一致的结果,支持了我们研究结果的稳健性。在所有模型中,跨类别的趋势检验仍然显著,表明全因死亡率风险存在剂量依赖性反应关系。第三,关于潜在的残留混淆,我们承认诸如营养状况、虚弱、抑郁和社会孤立等因素未包括在我们的分析中。我们的模型采用了四个阶段的顺序调整:模型1(年龄、性别);模型2(教育程度、社会经济地位、婚姻状况);模型3(吸烟、饮酒、BMI);模型4(糖尿病、心血管疾病、抗高血压药物)。虽然无法完全消除未测量的混杂因素,但我们的发现与先前证据的一致性以及在牙列类别中观察到的剂量-反应模式加强了真正关联的推断。第四,关于我们的死因特异性死亡率发现,我们同意该分析没有根据假牙佩戴习惯、卫生习惯或过夜使用来区分无牙个体。假牙与呼吸道死亡率的相关性最大(SHR = 1.57, 95% CI: 1.03-2.41),这可能与先前的研究一致,即假牙使用与吸入性肺炎风险增加有关。这些因素可能改变呼吸道死亡风险,这是我们研究的重要局限性。我们同意需要进一步的研究,包括检查潜在可改变的风险因素的介入性研究,如假牙卫生和口腔护理实践,以更好地了解牙齿脱落和呼吸相关死亡率之间关联的潜在机制。最后,我们感谢Somay博士提出的建设性意见,并就我们研究的影响展开对话。我们的研究通过在一个大型(n = 8494)全国代表性队列中展示牙齿脱落和全因死亡率之间的独立关联,有助于理解口腔健康-死亡率之间的关系,我们感谢记者对扩大这一研究框架的建议。我们感谢《美国老年病学会杂志》促进了这一宝贵的科学交流,并提供了作出回应的机会。构思与设计:L.W.和B.O.C.分析与解释,起草与修改稿件,审稿:所有作者。赞助者的角色:本文没有赞助者。作者声明无利益冲突。本出版物链接到Efsun Somay的相关信件。要查看本文,请访问https://doi.org/10.1111/jgs.70118。
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引用次数: 0
Brain Health Is Central to Good Perioperative Care in Older Adults 大脑健康是老年人良好围手术期护理的核心。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-24 DOI: 10.1111/jgs.70130
Karen E. Blackmon
<p>We are living in an era the United Nations has proclaimed “The Decade of Healthy Aging” [<span>1</span>]. The World Health Organization adopted a 2022–2031 intersectoral global action plan that envisages a “world in which brain health is valued, promoted, and protected across the life course; neurological disorders are avoided; and people affected by neurological disorders and their carers attain the highest possible level of health, with equal rights, opportunities, respect and autonomy” [<span>2</span>]. In this era of global attention to brain health, Canales and co-authors highlight a striking blind spot in geriatric perioperative care. They surveyed a large sample of older adults undergoing elective surgery and found that only 7% reported preoperative discussion with their health care providers about cognitive risks associated with surgery [<span>3</span>]. In follow-up interviews with people who experienced cognitive changes after surgery, they found that 90% did attempt to discuss their symptoms with a healthcare provider. Yet, none received counseling or guidance on how to manage or improve their cognitive symptoms. Instead, they were advised to wait and see if symptoms persisted.</p><p>This pattern represents a missed opportunity to promote active recovery, encourage healthy lifestyle behaviors, and protect the long-term brain health of older adults. Surgery can be life-extending, but if it accelerates or unmasks cognitive decline without empowering patients with the knowledge or tools they need for proactive management, then it risks undermining the very autonomy and quality of life that medical interventions aim to preserve.</p><p>Informed consent is not simply a legal formality; it is an ethical process that protects autonomy and builds trust. For older adults, especially those facing major surgery, autonomy extends beyond the right to say yes or no—it includes the right to understand the full spectrum of risks and benefits, including cognitive risks that affect identity, independence, and quality of life.</p><p>The American College of Surgeons National Surgical Quality Improvement Program, the American Geriatric Society Best Practices Guidelines, and the International Perioperative Neurotoxicity Working Group all recommend assessing cognitive ability for any patient older than 65 years to assess the risk of post-operative cognitive dysfunction [<span>4, 5</span>]. This process not only highlights the risk of perioperative neurocognitive disorder (PND) but also offers older adults the opportunity to consider their values and preferences around brain health. It can provide them with the awareness and vocabulary to self-monitor and report perioperative cognitive changes. Evidence consistently shows that patient education and self-efficacy are associated with improved surgical outcomes [<span>6</span>]. In the perioperative setting, structured education has been shown to reduce anxiety, improve pain management, and enhance recovery [<
我们生活在一个被联合国宣布为“健康老龄化十年”的时代。世界卫生组织通过了《2022-2031年部门间全球行动计划》,该计划设想了一个“在整个生命过程中重视、促进和保护大脑健康的世界;避免了神经系统疾病;受神经系统疾病影响的人及其照顾者享有尽可能高的健康水平,享有平等的权利、机会、尊重和自主权"。在这个全球关注大脑健康的时代,Canales和合著者强调了老年围手术期护理中一个引人注目的盲点。他们调查了大量接受选择性手术的老年人样本,发现只有7%的人报告术前与他们的医疗保健提供者讨论了与手术bbb相关的认知风险。在对手术后经历认知变化的人的随访中,他们发现90%的人确实试图与医疗保健提供者讨论他们的症状。然而,没有人接受过关于如何管理或改善他们的认知症状的咨询或指导。相反,他们被建议等待,看看症状是否会持续。这种模式错失了促进积极康复、鼓励健康生活方式行为和保护老年人长期大脑健康的机会。手术可以延长生命,但如果它加速或揭露了认知能力的下降,而没有赋予患者主动管理所需的知识或工具,那么它就有可能破坏医疗干预旨在维护的自主权和生活质量。知情同意不仅仅是一种法律程序;这是一个保护自主权和建立信任的道德过程。对于老年人,特别是那些面临大手术的老年人,自主权不仅仅是说“是”或“不是”的权利,还包括了解所有风险和利益的权利,包括影响身份、独立性和生活质量的认知风险。美国外科医师学会国家手术质量改进计划、美国老年学会最佳实践指南和国际围手术期神经毒性工作组都建议对任何年龄大于65岁的患者进行认知能力评估,以评估术后认知功能障碍的风险[4,5]。这一过程不仅突出了围手术期神经认知障碍(PND)的风险,而且为老年人提供了考虑他们在大脑健康方面的价值观和偏好的机会。它可以为患者提供自我监测和报告围手术期认知变化的意识和词汇。证据一致表明,患者教育和自我效能感与手术结果的改善有关。在围手术期,有组织的教育已被证明可以减少焦虑,改善疼痛管理,并增强恢复bb0。共同决策包括围绕患者的偏好和价值观进行对话,这在择期手术中至关重要,尤其是对那些面临更大伤害风险和决策后悔风险的老年人。然而,外科医生承认,在老年人术前计划中,主要关注的是风险指标,而不是个体患者的偏好。不会说英语的患者需要语言翻译可能会成为共同决策的额外障碍。金丝雀和他的同事们表明,一小部分说英语的患者确实记得与他们的医疗保健提供者讨论过认知风险-收益;然而,没有一个非英语母语者回忆起这种类型的讨论。语言障碍加剧了现有的脆弱性,使大量患者缺乏保护大脑健康的知识和工具。提供翻译服务和可获得的教育材料将确保所有患者的围手术期护理的公平进步。身体康复现在被广泛认为是在手术前有益的;它能提高活动性,心肺储备,减少并发症。认知康复同样应被视为高危患者围手术期护理的常规选择。新兴文献支持这种方法。在一项随机对照试验中,术前进行结构化认知训练的老年人术后认知功能障碍发生率较低。更多的试验正在进行中[12,13]。即使是简单的策略,如视觉方向提示、记忆检查表或参与认知刺激活动,也可以帮助患者感到有能力监控、保护甚至增强自己的大脑健康。此外,康复培养了一种能动性。患者不再是手术风险的被动接受者,而是成为康复的积极参与者。这不仅可以增强自我效能感,还可以减少焦虑,提高对护理的总体满意度。 手术后的认知恢复不是线性的。这是一个由多个相互作用的系统形成的动态过程:大脑的恢复能力、合并症的负担、围手术期的损害(如炎症、缺氧)和出院后的环境支持。动态系统建模提供了一个有用的视角。它将恢复定义为受基线脆弱性(诱发因素)、围手术期并发症(诱发因素)和持续的术后输入(延续因素)影响的轨迹。如果不加以处理,一个小小的扰动——比如谵妄发作——就会把老年人推入恶性循环,而积极的干预(早期活动、补水、睡眠卫生、社会参与)可以把轨迹推回到恢复的轨道上。大脑健康不是一成不变的;它可以被加强,也可以被削弱。病人需要确信,术后活力的下降并不意味着不可避免的衰弱。已知可降低痴呆风险的循证生活方式因素,如定期体育锻炼、地中海式饮食、认知丰富、社会联系和睡眠优化,在围手术期也同样重要[15,16]。当医生将这些干预措施不仅作为长期健康建议,而且作为手术恢复工具包的一部分时,患者可以设想切实的步骤来保护和重建他们的认知活力和储备。从这个意义上说,围手术期护理不应该是等待症状是否持续。它应该是关于在脆弱时期积极、动态地管理大脑健康。对许多老年人来说,大脑不仅仅是另一个器官;它是身份、自主和尊严的所在地。老年人往往更看重生活质量和独立性,而不是身体寿命。我们从Canales等人那里了解到,老年人对认知结果的偏好很少被激发出来。这引发了人们的担忧,即许多老年人可能被剥夺了在知情的情况下做出对他们最重要的选择的机会。真正尊重自主权需要的不仅仅是呈现标准的人身风险;它需要询问患者他们最看重的结果是什么,并将围手术期护理与他们的优先事项相结合。对一些人来说,保持认知健康可能比身体衰退的风险更重要。对其他人来说,情况可能正好相反。但是,必须给予所有人选择的机会和采取行动的工具,比如教育、认知康复和基于生活方式的大脑健康策略。尊重自主权意味着与患者合作,积极维护他们所重视的东西:他们的独立性、记忆和自我意识。如果我们成功了,我们可能会将手术从对老化大脑的威胁转变为加强其健康和恢复能力的机会(图1)。写了手稿。资金支持研究者时间,但不直接支持这个项目。所表达的观点代表作者的观点,而不代表发起人的观点。作者声明无利益冲突。本出版物链接到Canales等人的相关文章。要查看本文,请访问https://doi.org/10.1111/jgs.70063。
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引用次数: 0
Comment on “Tooth Loss and 12-Year Mortality Risk in 8494 Older Adults From Ireland” 对“8494名爱尔兰老年人牙齿脱落和12年死亡风险”的评论。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-24 DOI: 10.1111/jgs.70118
Efsun Somay
<p>I read with great interest the article by Winning et al. [<span>1</span>], which meticulously examines the relationship between self-reported dental health and both all-cause and cause-specific mortality within a robust, nationally representative sample of older adults aged 50 and above. I commend the authors for leveraging a comprehensive dataset that is invaluable for aging research. Their study included a thorough 12-year follow-up period and effectively controlled for a variety of confounding factors such as socioeconomic status, health behaviors, and pre-existing medical conditions, which could otherwise skew the results. The findings are particularly striking, indicating a 42% increased risk of all-cause mortality (hazard ratio [HR]: 1.42) among edentulous participants. Additionally, the study revealed significant links to specific causes of death, including respiratory mortality (subdistribution HR [SHR]: 1.57) and cancer mortality (SHR: 1.31). These results provide essential evidence that oral health is intricately linked to systemic health outcomes in aging populations, suggesting that poor dental health could serve as an early indicator of broader health issues, including overall health and long-term survival. Moreover, they underscore the urgent need for integrating oral healthcare into comprehensive geriatric medical assessments and preventive strategies. However, despite these significant findings, several analytical considerations warrant further evaluation.</p><p>First, the exposure variable in this study relied exclusively on a single baseline self-report, categorized into “dentate, no denture,” “dentate, with denture(s),” and “edentulous.” Although this approach is practical for extensive cohort studies, it presents lower accuracy compared to clinical examinations. Research has shown that there is only moderate agreement between self-reported dentition and clinical assessments, which may result in non-differential misclassification, potentially biasing HRs toward the null hypothesis [<span>2</span>]. This misclassification is particularly pertinent when distinguishing between partial and complete edentulism, as participants with limited residual teeth may misclassify themselves, especially when dental prostheses are involved. Moreover, factors such as denture fit, stability, and occlusal function—which significantly impact nutritional status and overall health—are not accounted for by a single self-reported item. Future research should focus on validating self-reported measures against clinical data or incorporating hybrid methods, such as dental records, photographs, or structured dental examinations, to improve the accuracy of these assessments. Additionally, the authors combined the original five response categories into three, resulting in the loss of valuable details, such as the distinction between partial dentition without dentures and complete dentition. Although this recoding may enhance statistical stability, it risk
我怀着极大的兴趣阅读了win et al. b[1]的一篇文章,该文章细致地研究了自我报告的牙齿健康与全因和特定原因死亡率之间的关系,研究对象是50岁及以上的全国代表性老年人样本。我赞扬作者利用了一个全面的数据集,这对衰老研究是无价的。他们的研究包括了一个完整的12年随访期,并有效地控制了各种混杂因素,如社会经济地位、健康行为和先前的医疗状况,否则这些因素可能会扭曲结果。研究结果尤其引人注目,表明无牙受试者的全因死亡率增加了42%(风险比[HR]: 1.42)。此外,该研究还揭示了与特定死亡原因的显著联系,包括呼吸系统死亡率(亚分布HR [SHR]: 1.57)和癌症死亡率(SHR: 1.31)。这些结果提供了重要的证据,表明口腔健康与老龄化人口的全身健康结果有着复杂的联系,表明牙齿健康状况不佳可以作为更广泛的健康问题的早期指标,包括整体健康和长期生存。此外,它们强调迫切需要将口腔保健纳入全面的老年医学评估和预防战略。然而,尽管有这些重要的发现,有几个分析考虑值得进一步评价。首先,本研究中的暴露变量完全依赖于单一基线自我报告,分为“有牙、无假牙”、“有牙、有假牙”和“无牙”。虽然这种方法适用于广泛的队列研究,但与临床检查相比,它的准确性较低。研究表明,自我报告的牙列与临床评估之间只有适度的一致性,这可能导致非鉴别错误分类,潜在地使hr偏向零假设[2]。这种错误分类在区分部分和完全全牙时特别相关,因为残牙有限的参与者可能会错误分类自己,特别是当涉及义齿时。此外,诸如假牙适合度、稳定性和咬合功能等因素——这些因素对营养状况和整体健康有显著影响——并不是由一个单独的自我报告项目来解释的。未来的研究应侧重于根据临床数据验证自我报告的措施,或结合混合方法,如牙科记录、照片或结构化牙科检查,以提高这些评估的准确性。此外,作者将最初的五种反应类别合并为三种,导致丢失了有价值的细节,例如没有假牙的部分牙列和完整牙列之间的区别。虽然这种重新编码可以增强统计稳定性,但它有可能模糊临床相关的细微差别,特别是在部分全牙症的情况下,其中功能损伤和风险轨迹与完全牙齿脱落相关的情况有很大不同。因此,使用原始的五个类别或评估功能牙齿单位的敏感性分析可以进一步了解风险梯度。其次,尽管统计模型根据各种社会人口因素以及生活方式行为(如吸烟和饮酒)以及慢性病的存在进行了调整,但仍然存在残留混淆的可能性。具体来说,诸如营养状况、虚弱、抑郁和社会孤立等因素没有被检查。此外,纳入心血管合并症作为协变量可能无意中介导了一些途径,可能导致分析中的过度调整。然而,现有的研究调查了口腔健康、饮食模式和全身性炎症之间的复杂关系,全面强调了这些问题[3,4]。第三,尽管与呼吸道死亡率的显著关联(SHR: 1.57)与先前的研究一致,将假牙使用与吸入性肺炎风险增加联系起来,但该分析并未根据假牙佩戴习惯、卫生习惯或过夜使用(已知可改变风险的因素)来区分无牙个体。同样,观察到的与癌症死亡率的联系(SHR: 1.31)可能受到残留混杂因素的影响,如吸烟和饮酒,这些因素与牙齿脱落、癌症风险和癌症死亡率密切相关[6,7]。因此,我相信对这些混杂因素的影响进行纵向前瞻性研究可以对这些问题产生有价值的见解。总之,win等人提出了有价值的证据,强调了口腔健康作为全身预后预测因子的作用。
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引用次数: 0
CAPABLE for People After Hospitalization: A Randomized Trial 住院后患者的CAPABLE:一项随机试验
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-24 DOI: 10.1111/jgs.70116
Sarah L. Szanton, David L. Roth, Kathryn Bowles, Nicole Onorato, Laura N. Gitlin, Bruce Leff

Background

Following hospitalization, nearly 30% of older adults lose some independence. This can lead to rehospitalization, nursing home admission, and increased dependence. CAPABLE, an evidence-based program, increases independence among older adults with functional limitations but has not been tested in recently hospitalized people.

Methods

This randomized clinical trial enrolled 268 low-income community-dwelling adults who had been discharged to home from the hospital 60 days prior, had a home health episode, yet had remaining difficulties in at least one activity of daily living. Participants were randomized to no further care or to CAPABLE, which involved up to 10 home visits over 5 months with an occupational therapist, a registered nurse, and a handyworker to address an older adult's self-identified functional goals. Main outcomes were (1) improvement in difficulty with and assistance needed for 10 activities of daily living (range 10–50); (2) five instrumental activities of daily living and mobility: walking up a set of stairs and walking a block.

Results

The CAPABLE group decreased their ADL difficulty by −1.76 (CI −2.98, −0.54) and the control group decreased (−0.63: CI −1.86, 0.60) over 5 months, which was not statistically or clinically significant. However, the CAPABLE treatment group demonstrated greater improvement in a composite mobility measure than control participants (−0.52 and −0.02, respectively, p = 0.028). Additionally, among participants with four or more co-morbidities at baseline, the CAPABLE group showed significantly improved ADL independence compared to control participants.

Conclusions

Among recently hospitalized persons receiving skilled home health care, CAPABLE did not improve ADLs. However, it improved functional mobility and benefited those with ≥ 4 comorbidities. This study provides novel information on targeting CAPABLE in the post-hospitalization period.

背景:住院后,近30%的老年人会失去一定程度的独立性。这可能导致再次住院,进入疗养院,并增加依赖性。CAPABLE是一个以证据为基础的项目,可以提高有功能限制的老年人的独立性,但尚未在最近住院的患者中进行测试。方法:这项随机临床试验招募了268名低收入社区居住的成年人,他们在出院60天前出院,有家庭健康问题,但至少在一项日常生活活动中仍然存在困难。参与者被随机分为无进一步护理组和CAPABLE组,其中包括在5个月内由职业治疗师、注册护士和手工工人进行多达10次家访,以解决老年人自我确定的功能目标。主要结果为:(1)10项日常生活活动的困难和需要帮助的改善(范围10-50);(2)日常生活和活动的五项工具性活动:走上一组楼梯和走过一个街区。结果:在5个月内,CAPABLE组患者的ADL困难降低了-1.76 (CI -2.98, -0.54),对照组患者的ADL困难降低了(-0.63:CI -1.86, 0.60),差异无统计学意义和临床意义。然而,与对照组相比,CAPABLE治疗组在综合活动能力测量方面表现出更大的改善(分别为-0.52和-0.02,p = 0.028)。此外,在基线时有四种或更多合并症的参与者中,与对照组相比,CAPABLE组表现出显著改善的ADL独立性。结论:在最近住院接受熟练家庭卫生保健的患者中,CAPABLE并没有改善ADLs。然而,它改善了功能活动能力,并使合并症≥4的患者受益。本研究为住院后靶向治疗CAPABLE提供了新的信息。
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引用次数: 0
Age of Patients in Trials Submitted to the FDA Versus Age in Average Patients With Cancer 向FDA提交试验的患者的年龄与癌症患者的平均年龄。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-23 DOI: 10.1111/jgs.70000
Alyson Haslam, Vinay Prasad

Background

The risk of cancer increases as people age, and yet, participants in oncology clinical trials have historically been younger than those in the general population with the respective tumor type, thus limiting our understanding of the safety and efficacy of trial results in the real world. The US Food and Drug Administration (FDA) has issued guidance on multiple occasions on the inclusion of older adults in clinical trials. We sought to evaluate whether there has been progress in the representativeness of older adults in oncology trials.

Methods

For oncology drug approvals since 2002, we searched for registration trials and collected data on the median age of study participants. We then searched SEER*Explorer to find the median age of the general population with the respective cancer type. We assessed linear trends to see if there were age gaps between the median ages of trial participants and SEER participants, and we assessed differences in time frames when guidance was issued.

Results

The age gap between registration trials and SEER data for all 22 years was 5 years (62 years for registration trials vs. 67 years for SEER). The age gap has declined over time (Beta = −0.22, p = 0.004) but still persists. Between 2002 and 2012, the age gap between registration trials and the SEER population was 7 years (59 vs. 66 years, p < 0.001); between 2013 and 2019, it was 5 years (62 vs. 67 years, p < 0.001); and between 2020 and 2024, the age gap was 4 years (63 vs. 67 years, p < 0.001).

Conclusion

We found that the age gap between registration trial participants and the general population with the respective tumor type has declined over time, but the age-gap persists, despite guidance issued by the FDA. Efforts to include more representative study participants in clinical trials should be intensified, possibly through greater enforcement through regulatory oversight.

背景:癌症的风险随着年龄的增长而增加,然而,肿瘤临床试验的参与者历来比具有相应肿瘤类型的普通人群年轻,从而限制了我们对现实世界中试验结果的安全性和有效性的理解。美国食品和药物管理局(FDA)已经多次发布了关于将老年人纳入临床试验的指导意见。我们试图评估在肿瘤学试验中老年人的代表性方面是否有进展。方法:对于2002年以来获得批准的肿瘤药物,我们检索了注册试验并收集了研究参与者的中位年龄数据。然后,我们搜索SEER*Explorer,以找到患有各自癌症类型的普通人群的中位年龄。我们评估了线性趋势,看看试验参与者和SEER参与者的中位年龄之间是否存在年龄差距,我们评估了指南发布时时间框架的差异。结果:注册试验和SEER数据之间的年龄差距为5年(注册试验为62年,SEER为67年)。年龄差距随着时间的推移而下降(Beta = -0.22, p = 0.004),但仍然存在。在2002年至2012年期间,注册试验和SEER人群之间的年龄差距为7岁(59岁对66岁)。结论:我们发现注册试验参与者和具有各自肿瘤类型的普通人群之间的年龄差距随着时间的推移而缩小,但年龄差距仍然存在,尽管FDA发布了指导意见。应该加强在临床试验中纳入更多代表性研究参与者的努力,可能通过监管监督加强执法。
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引用次数: 0
Certified Nursing Assistant Training Opportunities: Insights From States' Administrative Data 注册护理助理培训机会:来自各州行政数据的见解。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-23 DOI: 10.1111/jgs.70108
Mallory Niemzak Johnson, Noli Brazil, Michelle Ko
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引用次数: 0
“Someone to Remember I Need Help”: Multi-Site Mixed-Method Study of Older Inpatients' Experiences of Eating and Drinking “有人记得我需要帮助”:老年住院患者饮食经历的多地点混合方法研究。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-23 DOI: 10.1111/jgs.70104
Rhiannon Young, Jessica King, Adrienne M. Young, Mary Hannan-Jones, Alison M. Mudge, Angela Byrnes

Background

Hospital mealtimes are complex, and older adults are at high risk of inadequate food and fluid intake, which contributes to poorer hospital outcomes. Interventions to improve mealtimes and mealtime care should consider patient perspectives. This multi-site study aims to describe the eating and drinking experiences and perceptions of older adults admitted to 12 hospitals across Queensland, Australia.

Methods

Mixed-method study analyzing structured interviews with older inpatients (aged 65 years and older) collected within the Eat Walk Engage quality improvement program in 20 acute medical and surgical wards in 12 publicly funded hospitals (2019–20). Interviews were undertaken by trained staff and included patient perspectives, barriers, enablers, and suggestions related to eating and drinking in hospital. Qualitative data were coded using the Theoretical Domains Framework (TDF) and synthesized to create overarching belief statements.

Results

Two hundred interviews were analyzed. Nearly all (98%) patients described eating and drinking in hospital as important. Eighteen belief statements were generated across the seven most indexed TDF domains. Patients recognized eating and drinking as important to their strength and recovery and generally appreciated the quality and options in hospital food. However, they experienced multi-level challenges: at a personal level (e.g., reduced appetite, symptoms, and physical impairments); with mealtime care (e.g., lack of assistance and uncomfortable positioning); and from the broader hospital system (e.g., inflexible meal timing and meal sizes). Several enabling factors were identified, including self-motivation, encouragement and assistance from staff and family, greater choice around food, and familiar and simple foods.

Conclusions

Eating and drinking in hospital is complex for older patients. Improvement solutions should be multi-faceted and multi-disciplinary to provide effective person-centered nutrition care.

背景:医院用餐时间复杂,老年人食物和液体摄入不足的风险很高,这导致医院预后较差。改善用餐时间和用餐时间护理的干预措施应考虑患者的观点。这项多地点研究旨在描述澳大利亚昆士兰州12家医院收治的老年人的饮食经历和看法。方法:采用混合方法对12家公立医院2019- 2020年20个急症内科和外科病房的老年住院患者(65岁及以上)进行结构化访谈分析。访谈由训练有素的工作人员进行,内容包括患者的观点、障碍、促成因素和与医院饮食有关的建议。使用理论领域框架(TDF)对定性数据进行编码,并将其合成以创建总体信念陈述。结果:对200个访谈进行了分析。几乎所有(98%)患者都认为在医院饮食很重要。在7个索引最多的TDF域中生成了18个信念陈述。患者认识到饮食对他们的力量和恢复很重要,并且普遍对医院食物的质量和选择表示赞赏。然而,他们经历了多层次的挑战:在个人层面(例如,食欲减退、症状和身体损伤);用餐时需要照顾(例如,缺乏帮助和姿势不舒服);从更广泛的医院系统(例如,不灵活的用餐时间和用餐量)。确定了若干有利因素,包括自我激励、工作人员和家属的鼓励和援助、更多的食物选择以及熟悉和简单的食物。结论:老年患者住院饮食情况复杂。改善方案应是多方面和多学科的,以提供有效的以人为本的营养护理。
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引用次数: 0
Clinical and Prognostic Utility of the Essential Frailty Toolset in Older Patients With Heart Failure 基本衰弱工具集在老年心力衰竭患者中的临床和预后应用。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-22 DOI: 10.1111/jgs.70103
Daichi Maeda, Yuya Matsue, Nobuyuki Kagiyama, Yudai Fujimoto, Tsutomu Sunayama, Taishi Dotare, Taisuke Nakade, Kentaro Jujo, Kentaro Kamiya, Hiroshi Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Hiroshi Wada, Masaru Hiki, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Kazuki Wakaume, Kazuhiro Oka, Shin-ichi Momomura, Tohru Minamino

Background

Heart failure (HF) is associated with frailty, and most frailty assessment methods are subjective and complex. The Essential Frailty Toolset (EFT) is a simple, objective, and comprehensive frailty assessment tool. This study aimed to investigate the clinical and prognostic values of the EFT in patients with HF.

Methods

Data from a multicenter, observational study on older (≥ 65 years old) patients hospitalized with HF, the FRAGILE-HF cohort, was used. The EFT includes a five-time chair stand test, cognitive function assessment, and hemoglobin and albumin measurements. Patients were divided into three groups based on their EFT points: robust (0 points), pre-frail (1–2 points), and frail (3–5 points). The primary endpoint was 2-year all-cause mortality.

Results

Of the total 1237 patients (80.1 ± 7.1 years; 43% females), the robust, pre-frail, and frail groups included 114 (11.6%), 606 (49.0%), and 487 (39.4%) patients, respectively. The prevalence of frailty, evaluated using the Fried phenotype model, increased with increased EFT points (p < 0.001). Within the 2-year follow-up period, 256 deaths occurred. The frail group was significantly associated with a higher risk of the primary endpoint than the robust group (adjusted hazard ratio [aHR], 2.01; 95% confidence interval [CI], 1.12–3.61; p = 0.019). The EFT point, as a continuous variable, was significantly associated with the primary endpoint (aHR, 1.19; 95% CI, 1.08–1.31; p < 0.001). A significant continuous net reclassification improvement was observed when the EFT groups were added to the conventional risk model.

Conclusion

The EFT demonstrated valuable clinical and prognostic value in older patients with HF.

背景:心力衰竭(HF)与虚弱相关,大多数虚弱评估方法主观且复杂。基本脆弱性工具集(EFT)是一个简单、客观、全面的脆弱性评估工具。本研究旨在探讨EFT在心衰患者中的临床及预后价值。方法:采用一项多中心观察性研究数据,研究对象为住院HF的老年(≥65岁)患者,即FRAGILE-HF队列。EFT包括五次椅子站立测试、认知功能评估、血红蛋白和白蛋白测量。根据EFT评分将患者分为三组:健体(0分)、体弱前(1-2分)和体弱(3-5分)。主要终点是2年全因死亡率。结果:1237例患者(80.1±7.1岁,女性占43%)中,健体组114例(11.6%),体弱组606例(49.0%),体弱组487例(39.4%)。使用Fried表型模型评估的虚弱患病率随着EFT点数的增加而增加(p)。结论:EFT在老年HF患者中显示出有价值的临床和预后价值。
{"title":"Clinical and Prognostic Utility of the Essential Frailty Toolset in Older Patients With Heart Failure","authors":"Daichi Maeda,&nbsp;Yuya Matsue,&nbsp;Nobuyuki Kagiyama,&nbsp;Yudai Fujimoto,&nbsp;Tsutomu Sunayama,&nbsp;Taishi Dotare,&nbsp;Taisuke Nakade,&nbsp;Kentaro Jujo,&nbsp;Kentaro Kamiya,&nbsp;Hiroshi Saito,&nbsp;Yuki Ogasahara,&nbsp;Emi Maekawa,&nbsp;Masaaki Konishi,&nbsp;Takeshi Kitai,&nbsp;Kentaro Iwata,&nbsp;Hiroshi Wada,&nbsp;Masaru Hiki,&nbsp;Takatoshi Kasai,&nbsp;Hirofumi Nagamatsu,&nbsp;Tetsuya Ozawa,&nbsp;Katsuya Izawa,&nbsp;Shuhei Yamamoto,&nbsp;Naoki Aizawa,&nbsp;Kazuki Wakaume,&nbsp;Kazuhiro Oka,&nbsp;Shin-ichi Momomura,&nbsp;Tohru Minamino","doi":"10.1111/jgs.70103","DOIUrl":"10.1111/jgs.70103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Heart failure (HF) is associated with frailty, and most frailty assessment methods are subjective and complex. The Essential Frailty Toolset (EFT) is a simple, objective, and comprehensive frailty assessment tool. This study aimed to investigate the clinical and prognostic values of the EFT in patients with HF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from a multicenter, observational study on older (≥ 65 years old) patients hospitalized with HF, the FRAGILE-HF cohort, was used. The EFT includes a five-time chair stand test, cognitive function assessment, and hemoglobin and albumin measurements. Patients were divided into three groups based on their EFT points: robust (0 points), pre-frail (1–2 points), and frail (3–5 points). The primary endpoint was 2-year all-cause mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the total 1237 patients (80.1 ± 7.1 years; 43% females), the robust, pre-frail, and frail groups included 114 (11.6%), 606 (49.0%), and 487 (39.4%) patients, respectively. The prevalence of frailty, evaluated using the Fried phenotype model, increased with increased EFT points (<i>p</i> &lt; 0.001). Within the 2-year follow-up period, 256 deaths occurred. The frail group was significantly associated with a higher risk of the primary endpoint than the robust group (adjusted hazard ratio [aHR], 2.01; 95% confidence interval [CI], 1.12–3.61; <i>p</i> = 0.019). The EFT point, as a continuous variable, was significantly associated with the primary endpoint (aHR, 1.19; 95% CI, 1.08–1.31; <i>p</i> &lt; 0.001). A significant continuous net reclassification improvement was observed when the EFT groups were added to the conventional risk model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The EFT demonstrated valuable clinical and prognostic value in older patients with HF.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 11","pages":"3455-3463"},"PeriodicalIF":4.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of the American Geriatrics Society
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