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Precision medicine and patient-centered outcomes: Learning from APOE for prevention clinical trials in older adults 精准医学和以患者为中心的结果:从 APOE 中学习老年人预防临床试验。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-16 DOI: 10.1111/jgs.19097
Nicholas M. Pajewski PhD
<p>For conditions that often entail significant impairment, such as Alzheimer's disease or stroke, there is an established standard in clinical trials to adopt outcome measures that integrate function in both cognitive and physical domains, such as the Clinical Dementia Rating Scale<span><sup>1</sup></span> and the modified Rankin Scale.<span><sup>2</sup></span> What is perhaps a newer direction is adopting a similar paradigm, blending the brain and the body, within the context of prevention. Several recent trials including ASPREE (Aspirin in Reducing Events in the Elderly),<span><sup>3</sup></span> STAREE (Statins in Reducing Events in the Elderly),<span><sup>4</sup></span> and PREVENTABLE (Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults)<span><sup>5</sup></span> have adopted a primary composite outcome of survival free of dementia and disability, integrating the incidence of all-cause dementia, persistent disability in activities of daily living, and all-cause mortality. The appeal of this outcome is that it is inherently patient-centric, focused on the foundational goal of maintaining functional independence in aging populations. However, as with anything new, there are still a myriad of questions that need to be explored before adopting survival free of dementia and disability as the default outcome choice for prevention trials in older adults. Does it conform, in theory and in practice, to recommendations for adopting composite outcomes?<span><sup>6</sup></span> What interventions might be most likely to prevent both incident disability and cognitive impairment? What risk factors should one consider in trying to optimize inclusion and exclusion criteria, as well as event rates? What role does precision medicine have with such an endpoint?</p><p>In this issue of the <i>Journal of the American Geriatrics Society</i>, Clocchiatti-Tuozzo et al. begin to examine the latter two questions through the lens of genetics, evaluating the association of apolipoprotein E (<i>APOE</i>) genotypes with the incidence of dementia, disability, and all-cause mortality in the Health and Retirement Study.<span><sup>7</sup></span> Among 14,527 older adults (median age 55 years, 58% female, >70% of European ancestry, 25% carriers of at least one <i>APOE</i> ε4 allele), without dementia or disability at baseline followed for a median of 18 years, carriers of the <i>APOE</i> ε4 allele had an increased incidence of the composite outcome of incident dementia, disability, or death (adjusted hazard Ratio (aHR) = 1.15, 95% CI: 1.09–1.21), while being a carrier of the <i>APOE</i> ε2 genotype was associated with a non-statistically significant decrease in risk for that outcome (aHR = 0.94, 95% CI: 0.87–1.01). In looking at the individual components of the composite outcome, carrying the <i>APOE</i> ε4 allele was associated with increased risk of dementia and mortality, but not disability (aHR = 0.98, 95% CI: 0.89–1.08). In secondary analyses
亚临床疾病的生物标志物,如基于计算机断层扫描成像的冠状动脉钙,在心血管疾病的临床决策中可能具有更高的实用性。其次,对于将无痴呆和无残疾存活率作为结果的未来临床试验而言,主要关注 APOE 是否足够,还是应该考虑更广泛的阿尔茨海默病、脑小血管疾病和/或心血管疾病的多基因风险?最后,APOE ε4变异与痴呆症和全因死亡率相关,但与残疾无关,这一结果微妙地提醒人们生理学的复杂性,以及它如何可能破坏设计良好的综合结果。从表面上看,痴呆症和身体残疾满足了作为试验结果的许多必要条件。两者都是有临床意义的终点,对患者来说非常重要。与这两种病症相关的生理过程有很大的重叠,因此可以合理地预期,药物或其他干预措施可以同时预防痴呆症和残疾。13 然而,过去的老年医学临床试验经验表明,结果参差不齐或无效是常态,据我所知,只有一个例子表明干预措施同时对认知功能或痴呆症和身体功能或残疾有益处(表 1)。这些经验无疑促使我思考,无论从患者的角度来看,无痴呆症和无残疾的生存是否是一个过于宏大的目标。尽管如此,迄今为止的大多数随机试验并没有显示出对比效应,即一种疗法减少了持续性残疾的发生,但却增加了痴呆症的风险。如果情况是一个领域普遍受益,而对另一个领域没有影响,那么主要的风险就是治疗效果被稀释,统计能力不足。不过,在设计未来的试验时可以预见到这种情况,如果没有明确的先验预期,干预措施是否更有可能预防痴呆症而不是残疾,那么这种权衡可能是可以接受的。另一个需要注意的问题是芬兰老年干预研究预防认知障碍和残疾试验的结果,以及目前向测试多领域干预措施的转变。虽然这些结果与 "Muitidomain 阿尔茨海默预防试验 "的结果形成了鲜明对比,但我预计,随着该领域对更多的多领域干预措施进行评估,或许会将饮食和运动与二甲双胍、钠-葡萄糖共转运体-2 抑制剂、胰高血糖素样肽-1 激动剂或治疗阿尔茨海默病的单克隆抗体疗法等药理制剂结合起来,随机试验证据的总结可能会开始变得不同。总之,Clocchiatti-Tuozzo 等人的研究为评估 APOE 在 STAREE 和 PREVENTABLE 等试验中的作用提供了更多支持。除此之外,这项研究提出的问题远远多于答案。不过,它提供了一个适时的机会,让我们思考老年人预防试验的未来,以及遗传学和精准医学如何在微调旨在保持功能独立的疗法的风险和收益平衡方面发挥作用。Pajewski博士是PREVENTABLE试验的研究者,由美国国立卫生研究院(National Institutes of Health)与PREVENTABLE试验相关的U19AG065188、R01HL155396、R01AG071807和R01AG081287号基金资助。
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引用次数: 0
Beyond flashing lights and sirens: Community paramedicine as health safety nets for older adults 超越闪光灯和警笛:社区辅助医疗是老年人的健康安全网。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-15 DOI: 10.1111/jgs.19087
Alexander J. Ulintz MD, Carmen E. Quatman MD, PhD
<p>Providing unscheduled, acute, and longitudinal care to older adults who are aging in place is a critical, yet largely unsolved, health system challenge. A large gap exists between the times and places where older adults need care and the resources available to address those needs.<span><sup>1</sup></span> Despite efforts to increase older adults' access to in-home care through home-based primary care, telemedicine, and workforce development, persistent gaps prompted recent calls by the American Geriatrics Society and the American Association of Geriatric Psychiatry to expand the “team based geriatric physician and health professional workforce by nontraditional means.”<span><sup>2, 3</sup></span> This creates an opportunity for innovative, multidisciplinary, patient-centered teams to bridge the gap.</p><p>Emergency medical services (EMS) agencies and clinicians are often called upon to fill this gap: they are accessible, mobile, and a trusted source of care in communities across the nation.<span><sup>4</sup></span> Though originally designed for emergency treatment and transportation of the critically ill and injured, EMS clinicians are increasingly embracing roles that span community outreach, prevention, and chronic disease management in a model of care known as “community paramedicine.”<span><sup>5</sup></span> Community paramedicine is designed to fill the space between fixed medical system resources and dynamic community needs by leveraging availability, accessibility, and versatile skills of EMS clinicians working as part of physician-led or multidisciplinary team. This model of care is of clear importance to older adults who are aging in place.</p><p><i>JAGS</i> has been at the forefront of rigorous examination of the community paramedicine model of care for older adults. As early as 1968, Mel Spear advocated for the concept of a physician-led, team-based, patient-centered approach to physical, emotional, and social well-being of older adults in “Paramedical Services for Older Adults.”<span><sup>6</sup></span> More recently, <i>JAGS</i> authors have described an array of community paramedicine programs tailored to the needs of older adults, including providing urgent, in-home, integrated evaluation and treatment to avoid unnecessary EMS transportation of medically complex older adults,<span><sup>7, 8</sup></span> facilitating the ED-to-home care transition,<span><sup>9</sup></span> using 9-1-1 calls as a sentinel event to prompt fall prevention intervention,<span><sup>10, 11</sup></span> and integrating community paramedics into home-based primary care practices to extend telehealth geriatrician reach and efficiency.<span><sup>12</sup></span> Additional program examples support the feasibility, effectiveness, and short-term health outcomes of community paramedicine for older adults.<span><sup>13-15</sup></span> However, limited data describe patient safety, process and health outcomes, and sustainable financial models for community para
为居家养老的老年人提供计划外、急诊和纵向护理是医疗系统面临的一项重要挑战,但在很大程度上尚未得到解决。老年人需要护理的时间和地点与满足这些需求的可用资源之间存在巨大差距。尽管通过居家初级保健、远程医疗和劳动力发展努力增加老年人获得居家护理的机会,但持续存在的差距促使美国老年医学会和美国老年精神病学协会最近呼吁 "通过非传统手段扩大以团队为基础的老年医学医生和保健专业人员队伍"。"2, 3 这为创新的、多学科的、以患者为中心的团队创造了机会,以弥补这一差距。紧急医疗服务(EMS)机构和临床医生经常被要求填补这一差距:他们方便、机动,是全国各社区值得信赖的医疗来源。5 社区辅助医疗旨在利用急救医疗服务临床医生的可用性、可及性和多方面技能,填补固定医疗系统资源与动态社区需求之间的空白,是医生领导的或多学科团队的一部分。这种护理模式对于居家养老的老年人显然具有重要意义。"JAGS "一直站在最前沿,对社区辅助医疗护理老年人的模式进行严格研究。早在 1968 年,梅尔-斯皮尔(Mel Spear)就在《老年人辅助医疗服务》一书中倡导以医生为主导、以团队为基础、以病人为中心的理念,为老年人提供身体、情感和社会福祉方面的服务。"6 最近,JAGS 的作者介绍了一系列针对老年人需求的社区辅助医疗项目,包括提供紧急、居家、综合评估和治疗,以避免对病情复杂的老年人进行不必要的急救运送,7, 8 促进急诊室到居家护理的过渡,9 将 9-1-1 电话作为哨点事件,以促使采取预防跌倒的干预措施,10, 11 以及将社区辅助医疗人员整合到居家初级保健实践中,以扩大老年远程医疗的覆盖范围并提高效率。其他项目实例也证明了社区辅助医疗对老年人的可行性、有效性和短期健康效果。在本期 JAGS 杂志上,Parsons 等人研究了影响老年人护理的一个常见临床难题:临床医生如何平衡评估患有痴呆症和计划外急症护理需求的社区居住老年人的需求与接触和往返急症护理机构进行评估相关的先天性伤害风险?作者利用社区辅助医疗服务为其居家初级医疗团队提供服务,让老年人及时获得医疗服务,同时避免了传统计划外急症护理模式的风险。除了实现证明社区辅助医疗干预对老年痴呆症患者的安全性这一主要目标外,作者还指出了三项适用于更广泛的老年医学领域的相关发现。16 此外,在接受社区辅助医疗项目评估的患者中,痴呆症患者更有可能被转诊至临终关怀机构。虽然这并不是本研究的主要结果,但这一发现凸显了社区辅助医疗项目在改变患者临床轨迹方面的潜力,而这些患者在临近生命终点时往往会陷入急症护理的漩涡。这一独特的发现为越来越多的文献基础增添了新的内容,这些文献支持社区辅助医疗项目能够利用居家急症护理评估来促进适当的转诊和周边服务,正如之前针对跌倒和脆性骨折等病症所证明的那样。10, 11 最后,这种护理模式利用了多种资金来源:作为医疗系统责任护理组织一部分的价值护理、远程医疗就诊报销以及基于数量的计费,从而在上述其他社区辅助医疗项目主要使用的单一资金来源的基础上更进一步。
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引用次数: 0
Managing medications among individuals with mild cognitive impairment and dementia: Patient-caregiver perspectives 轻度认知障碍和痴呆症患者的药物管理:患者-护理人员的观点。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-15 DOI: 10.1111/jgs.19065
Rachel O'Conor PhD, MPH, Andrea M. Russell PhD, Allison Pack PhD, MPH, Dianne Oladejo BA, Sarah Filec MPH, Emily Rogalski PhD, Darby Morhardt PhD, Lee A. Lindquist MD, MPH, MBA, Michael S. Wolf PhD, MPH
<div> <section> <h3> Background</h3> <p>With changing cognitive abilities, individuals with mild cognitive impairment (MCI) and dementia face challenges in successfully managing multidrug regimens. We sought to understand how individuals with MCI or dementia and their family caregivers manage multidrug regimens and better understand patient-to-caregiver transitions in medication management responsibilities.</p> </section> <section> <h3> Methods</h3> <p>We conducted qualitative interviews among patient–caregiver dyads. Eligibility included: patients with a diagnosis of MCI, mild or moderate dementia, managing ≥3 chronic conditions, ≥5 prescription medications, who also had a family caregiver ≥18 years old. Semi-structured interview guides, informed by the Medication Self-Management model, ascertained roles and responsibilities for medication management and patient-to-caregiver transitions in medication responsibilities.</p> </section> <section> <h3> Results</h3> <p>We interviewed 32 patient–caregiver dyads. Older adults and caregivers favored older adult autonomy in medication management, and individuals with MCI and mild dementia largely managed their medications independently using multiple strategies (e.g., establishing daily routines, using pillboxes). Among individuals with moderate dementia, caregivers assumed all medication-related responsibilities except when living separately. In those scenarios, caregivers set up organizers and made reminder calls, but did not observe family members taking medications. Patient-to-caregiver transitions in medication responsibilities frequently occurred after caregivers observed older adults making errors with medications. As caregivers sought to assume greater responsibilities with family members' medicines, they faced multiple barriers. Most barriers were dyadic; they affected both the older adult and the caregiver and/or the relationship. Some barriers were specific to caregivers; these included caregivers' competing responsibilities or inaccurate perceptions of dementia, while other barriers were related to the healthcare system.</p> </section> <section> <h3> Conclusions</h3> <p>To ease medication management transitions, balance must be sought between preservation of older adult autonomy and early family caregiver involvement. Clinicians should work to initiate conversations with family caregivers and individuals living with MCI or dementia about transitioning medication responsibilities as memory loss progresses, simplify regimens, and deprescribe, as appropriate.</p> </section>
背景:随着认知能力的改变,轻度认知障碍(MCI)和痴呆患者在成功管理多种药物治疗方案方面面临挑战。我们试图了解轻度认知障碍(MCI)或痴呆症患者及其家庭照顾者是如何管理多种药物治疗方案的,并更好地了解患者与照顾者之间在药物管理责任方面的转变:我们对患者和护理人员进行了定性访谈。符合条件的患者包括:诊断为 MCI、轻度或中度痴呆的患者,管理的慢性病≥3 种,处方药≥5 种,且其家庭照顾者年龄≥18 岁。根据用药自我管理模式制定的半结构式访谈指南确定了用药管理的角色和责任,以及患者与护理人员在用药责任方面的转变:结果:我们采访了 32 个患者-护理人员二人组。老年人和照护者都倾向于让老年人自主管理药物,患有 MCI 和轻度痴呆症的患者在很大程度上使用多种策略(如建立日常作息习惯、使用药盒)独立管理药物。在中度痴呆患者中,护理人员承担了所有与用药相关的责任,除非他们分开居住。在这些情况下,照护者会设置组织者并拨打提醒电话,但不会观察家庭成员服药。患者与照护者之间用药责任的转变经常发生在照护者观察到老年人用药出错之后。当照护者试图对家庭成员的用药承担更大责任时,他们面临着多重障碍。大多数障碍都是双方面的,既影响老年人,也影响照顾者和/或他们之间的关系。有些障碍是照顾者特有的,其中包括照顾者的责任竞争或对痴呆症的不正确认识,而其他障碍则与医疗保健系统有关:为了缓解药物管理的过渡,必须在维护老年人自主权和家庭照顾者早期参与之间寻求平衡。临床医生应努力与家庭照护者和 MCI 或痴呆症患者就随着记忆力减退而过渡用药责任展开对话,简化用药方案,并酌情取消处方。
{"title":"Managing medications among individuals with mild cognitive impairment and dementia: Patient-caregiver perspectives","authors":"Rachel O'Conor PhD, MPH,&nbsp;Andrea M. Russell PhD,&nbsp;Allison Pack PhD, MPH,&nbsp;Dianne Oladejo BA,&nbsp;Sarah Filec MPH,&nbsp;Emily Rogalski PhD,&nbsp;Darby Morhardt PhD,&nbsp;Lee A. Lindquist MD, MPH, MBA,&nbsp;Michael S. Wolf PhD, MPH","doi":"10.1111/jgs.19065","DOIUrl":"10.1111/jgs.19065","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;With changing cognitive abilities, individuals with mild cognitive impairment (MCI) and dementia face challenges in successfully managing multidrug regimens. We sought to understand how individuals with MCI or dementia and their family caregivers manage multidrug regimens and better understand patient-to-caregiver transitions in medication management responsibilities.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We conducted qualitative interviews among patient–caregiver dyads. Eligibility included: patients with a diagnosis of MCI, mild or moderate dementia, managing ≥3 chronic conditions, ≥5 prescription medications, who also had a family caregiver ≥18 years old. Semi-structured interview guides, informed by the Medication Self-Management model, ascertained roles and responsibilities for medication management and patient-to-caregiver transitions in medication responsibilities.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We interviewed 32 patient–caregiver dyads. Older adults and caregivers favored older adult autonomy in medication management, and individuals with MCI and mild dementia largely managed their medications independently using multiple strategies (e.g., establishing daily routines, using pillboxes). Among individuals with moderate dementia, caregivers assumed all medication-related responsibilities except when living separately. In those scenarios, caregivers set up organizers and made reminder calls, but did not observe family members taking medications. Patient-to-caregiver transitions in medication responsibilities frequently occurred after caregivers observed older adults making errors with medications. As caregivers sought to assume greater responsibilities with family members' medicines, they faced multiple barriers. Most barriers were dyadic; they affected both the older adult and the caregiver and/or the relationship. Some barriers were specific to caregivers; these included caregivers' competing responsibilities or inaccurate perceptions of dementia, while other barriers were related to the healthcare system.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To ease medication management transitions, balance must be sought between preservation of older adult autonomy and early family caregiver involvement. Clinicians should work to initiate conversations with family caregivers and individuals living with MCI or dementia about transitioning medication responsibilities as memory loss progresses, simplify regimens, and deprescribe, as appropriate.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"72 10","pages":"3011-3021"},"PeriodicalIF":4.3,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single item screen for clinically significant insomnia symptoms in community-living older adults 社区生活老年人临床重大失眠症状的单项筛查。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-15 DOI: 10.1111/jgs.19086
Lucy Webster PhD, Joshua Hobbs BS, Shelli Farhadian MD, PhD, Thomas M. Gill MD, Brienne Miner MD, MHS
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引用次数: 0
Commentary on: Cost-effectiveness of pneumococcal vaccination and of programs to increase its uptake in U.S. older adults 评论:肺炎球菌疫苗接种的成本效益以及提高美国老年人接种率的计划。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-15 DOI: 10.1111/jgs.19079
Melissa K. Andrew MD, PhD
<p>Pneumococcal illness, including both invasive disease and pneumonia, is especially relevant for older adults. Notably, the burden of disease increases with age, as does the risk of adverse outcomes which include both short- and long-term sequalae.<span><sup>1-8</sup></span> Several pneumococcal vaccines are currently available, including conjugate (PCV) and polysaccharide (PPV) vaccines covering different numbers of pneumococcal serotypes chosen to represent those causing the greatest burden of severe illness. Current both ACIP (the US Advisory Committee on Immunization Practices) and NACI (Canada's National Advisory Committee on Immunization) recommend PCV20 (or PCV15 + PPV23) for adults aged 65+ or with certain high-risk conditions.<span><sup>9, 10</sup></span></p><p>Despite older adults being among the groups most in need of protection, the benefit they derive from vaccines to date has been suboptimal, because of two issues: (1) suboptimal vaccine effectiveness (VE) in older adults due to immune dysregulation (in which efforts to tailor vaccine product composition, e.g. dose and adjuvants, and their delivery, e.g. dosing intervals, and number of doses, may be helpful) and (2) suboptimal uptake of vaccines that are recommended and available.<span><sup>11</sup></span> Targets for vaccine coverage in adults vary by jurisdiction, but a target of 80% is often put forth for pneumococcal vaccine coverage in older adults and adults with high-risk conditions.</p><p>When we further explore the suboptimal immunization coverage seen for all older adults, people in population groups facing historical and present social and structural disadvantage, and those in racialized groups, tend to experience compounded barriers in access and uptake to preventative interventions including vaccination.<span><sup>12-14</sup></span> It is therefore important to consider whether programs developed with and for these communities will be beneficial in achieving better vaccination uptake.</p><p>In the current issue, Wateska et al. present a study examining cost-effectiveness of pneumococcal vaccination for older adults and targeted programs to increase its uptake.<span><sup>15</sup></span> They used Markov decision analysis models comparing hypothetical one-year age band cohorts of Black and non-Black US adults aged 65 years and compared strategies of no vaccination, vaccination per current ACIP/CDC guidelines, and vaccination plus implementation of a program aiming to increase vaccine uptake.</p><p>They found that adult pneumococcal programs using PCV20 or PCV15 + PPV23 targeting a cross-sectional single year cohort of older adults 65 years of age are unlikely to be cost-effective, with all options having Incremental Cost-Effectiveness Ratios (ICERs) of more than $200,000 per Quality Adjusted Life Year (QALY). The authors conducted probabilistic sensitivity analyses varying many of the model assumptions and still found that these were unlikely to be cost-effective at thr
由于认识到肺炎球菌疾病的风险会随着年龄的增长而增加,他们进行了一组额外的分析,旨在解决包括 65 岁以上成年人在内的疫苗接种计划或使用更大年龄分界线是否会影响成本效益以及如何影响成本效益的问题。在这些分析中,他们还考虑到了随着年龄的增长,预期疫苗效力会降低的因素。在同时改变肺炎球菌疾病风险和 VE 的情况下,他们发现,如果疾病风险比 65-79 岁人群高出 40%-60% ,那么 PCV20 疫苗接种计划在 200,000 美元/QALY 的临界值下可被视为具有成本效益。补充图 S4 所示的这一分析对于细致解释这一问题至关重要,因为疫苗计划不可能只针对一个年龄段,尤其是建议接种疫苗的年龄段中患病风险最低的那一年龄段,因此成本效益可能最低。鉴于风险随着年龄的增长而持续但非线性地增加,即使在 65-79 岁年龄组中也是如此,因此必须考虑利用较高年龄分界线的疫苗接种计划是否更具成本效益。(图 1)此外,鉴于老年人的风险不仅来自于实际年龄,还来自于不同的健康状况和虚弱程度,因此为老年人群中风险最高的人群量身定制疫苗接种策略仍是另一个有待进一步研究的重要选择。19 总体而言,对于与年龄和体弱有关的免疫原性和疫苗有效性,以及这些疫苗对老年人和高危人群或体弱人群的保护持续时间,还需要开展更多的工作。举个实际例子,如果高危人群在较年轻时接种疫苗,这种保护作用能持续多久?尽管在 65 岁人群中实施肺炎球菌疫苗接种的基本案例模型(无论是否实施了提高接种率的计划)似乎并不具有成本效益,但他们的补充分析表明,有两种潜在的方法值得进一步考虑:(1) 在高年龄组或高风险人群中实施,和/或 (2) 在儿童计划间接受益的情况下,定制疫苗以包括对老年人造成最大负担的独特肺炎球菌血清型。MKA 是唯一的撰稿人。MKA 报告称,赛诺菲、葛兰素史克、默克和辉瑞公司为老年人疫苗可预防疾病的相关研究提供了资助,并且是加拿大国家免疫咨询委员会的成员。
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引用次数: 0
State home- and community-based services spending and unmet care needs by living arrangements and cognitive impairment status 按生活安排和认知障碍状况分列的州家庭和社区服务支出和未满足的护理需求。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-15 DOI: 10.1111/jgs.19088
Yulin Yang PhD, Ah-Reum Lee PhD, Elena Portacolone PhD, Thomas Rapp PhD, Jacqueline M. Torres PhD
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引用次数: 0
Providing better care for dually insured Medicare/Medicaid beneficiaries with advanced chronic illness 为患有晚期慢性病的医疗保险/医疗补助双重保险受益人提供更好的护理。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-12 DOI: 10.1111/jgs.19085
Peter Boling MD, George Taler MD, Bruce Kinosian MD
<p>Kim et al.<span><sup>1</sup></span> have reported one of the few published large-scale, multi-state evaluations of the impact of enrolling patients in Fully-Integrated Dual Eligible (FIDE) Special Needs Plan (SNP) insurance models available to Medicare and Medicaid beneficiaries, compared with enrolling in standard SNP duals plans (D-SNPs). The authors found no overall impact of increased financial integration at the plan level on a range of outcomes that integration of care at the patient-provider level have impacted.<span><sup>2, 3</sup></span> However, for two higher-risk dual subgroups, either those using home- and community-based services or those meeting modified Independence at Home high needs qualifying criteria,<span><sup>4</sup></span> Kim et al. found FIDE beneficiaries were likely to have lower hospitalization rates, compared to patients in dually eligible insurance models with less required integration.</p><p>It is dispiriting to see essentially no overall difference in service use patterns between individuals enrolled in FIDE plans, where Medicaid funds that support Long Term Services and Supports (LTSS) are managed by the same legal entity as Medicare funds, and other D-SNPs which have variable levels of coordination between Medicare and Medicaid services. This finding follows a decade when D-SNP growth reached 40% of eligible Duals, and FIDE SNP growth 8% of D-SNP enrollees. This finding is in line with other work by several of the study's authors, for example, noting a modest increase in Home and Community Based Services (HCBS) services but little impact on outcomes in Pennsylvania's effort to integrate care in its managed LTSS program, Community Health Choices.<span><sup>5</sup></span> The finding of limited impacts suggests that a more robust, better targeted, intervention is needed than simply merging the pools of dollars and encouraging health plans to find ways to integrate care. Still, the strategy of combining Medicare and Medicaid funding under a <i>single private sector insurer</i>, hopefully lessening the artificial separation of medical care and community-based supports, continues to be favored by many subject experts and legislators as a means of reducing care fragmentation and blunting the cost curve for the most vulnerable and costly US citizens.<span><sup>6-9</sup></span></p><p>While funding may be integrated at the plan level in these new models, the Medicare and Medicaid benefits are often structurally separate, or are operationally separate due to organizational culture. Due to data limitations, the authors were unable to test the effects of different organizational cultures or structures on outcomes, nor the strength of the integration in some obvious ways, such as testing whether FIDE plans were better able to substitute less expensive Medicaid HCBS services for more expensive Medicare services and institutional long-term care. Ultimately, we still lack insight into how well the top-level financial integrat
Kim 等人1 报道了一项为数不多的公开发表的大规模、多州评估,评估了患者加入完全整合的双重资格(FIDE)特殊需求计划(SNP)保险模式对医疗保险和医疗补助受益人的影响,与加入标准 SNP 双重计划(D-SNP)的影响进行了比较。作者发现,在计划层面加强财务整合对一系列结果没有总体影响,而在患者-医疗服务提供者层面整合医疗服务则会对这些结果产生影响、3 然而,对于两个风险较高的双重分组,即使用家庭和社区服务的分组或符合修改后的 "居家独立 "高需求资格标准的分组,4 Kim 等人发现,与整合要求较低的双重资格保险模式中的患者相比,FIDE 受益人的住院率可能较低。令人沮丧的是,参加 FIDE 计划(支持长期服务和支持(LTSS)的医疗补助基金与医疗保险基金由同一法人实体管理)的个人与参加其他 D-SNPs 的个人在服务使用模式上基本没有整体差异,而其他 D-SNPs 在医疗保险和医疗补助服务之间的协调程度各不相同。在此之前的十年中,D-SNP 的增长达到符合条件的双职工的 40%,而 FIDE SNP 的增长达到 D-SNP 参保者的 8%。这一发现与本研究中几位作者的其他研究结果一致,例如,宾夕法尼亚州在其管理性 LTSS 计划 "社区健康选择 "中整合医疗服务的努力中,注意到家庭和社区服务(HCBS)服务略有增加,但对结果影响甚微。尽管如此,将联邦医疗保险和医疗补助计划的资金合并到单一的私营保险公司,希望减少医疗护理和社区支持的人为分离,这一策略仍然受到许多专家和立法者的青睐,被认为是减少护理分散性和钝化美国最弱势和最昂贵公民的成本曲线的一种手段。6-9 虽然在这些新模式中,资金可能会在计划层面进行整合,但联邦医疗保险和医疗补助计划的福利通常在结构上是分离的,或者由于组织文化而在操作上是分离的。由于数据限制,作者无法测试不同的组织文化或结构对结果的影响,也无法测试某些明显方式的整合强度,例如测试 FIDE 计划是否更有能力用较便宜的医疗补助 HCBS 服务替代较昂贵的医疗保险服务和机构长期护理。在表 1 中,我们列出并对比了以提供者团队为中心的护理整合模式,以及更依赖于计划层面的财务管理和护理协调的整合模式,并按照整合程度的递减进行排序。与依赖于集中管理的护理协调方式的支付方管理型护理不同,医疗服务提供者整合护理的方法已被证明能有效降低高成本双重资格受益人的综合成本,集中的资金与有效的地方、个人规模的临床模式相联系,该模式针对目标人群的需求,并通过基于价值的资金激励提供合理的护理。其中一个成功的模式是老年人全包护理计划(PACE),这是一个全风险合同,主要针对弱势患者,几乎所有患者都有医疗保险和医疗补助计划双重保险,他们都是慢性病患者,入院时符合入住养老院的条件。11 在 PACE 中,Medicaid 和 Medicare 资源由一个跨学科小组(IDT)管理,该小组直接照顾参保者,PACE 规定该小组负责提供任何促进或维持健康所需的服务。这不同于 SNP 中更典型的中介安排,在 SNP 中,护理经理可能与护理服务脱节。广泛的 PACE 授权鼓励并授权 IDT 在需要时创造性地调配资源,而不是遵循传统规则。PACE 对参与者的生活和医疗保健利用率产生了影响,但其代价是对 PACE 中心进行大量资本投资,该中心既是社交中心,又是提供全面服务的诊所,此外,IDT 的人员和行政管理费用也较高。
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引用次数: 0
The association between social risks and days at home for older veterans 老年退伍军人的社会风险与在家天数之间的关联。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-12 DOI: 10.1111/jgs.19064
Josephine C. Jacobs PhD, Liberty Greene MS, MEd, Mayuree Rao MD, MS, Valerie A. Smith DrPH, Courtney H. Van Houtven PhD, Matthew L. Maciejewski PhD, Donna M. Zulman MD, MS

Background

Many health systems are trying to support the ability of older adults to remain in their homes for as long as possible. Little is known about the relationship between patient-reported social risks and length of time spent at home. We assessed how social risks were associated with days at home for a cohort of older Veterans at high risk for hospitalization and mortality.

Methods

A prospective cross-sectional study using a 2018 survey of 3479 high-risk Veterans aged ≥65 linked to Veterans Health Administration data. Social risks included measures of social resources (i.e., no partner present, low social support), material resources (i.e., not employed, financial strain, medication insecurity, food insecurity, and transportation barriers), and personal resources (i.e., low medical literacy and less than high school education). We estimated how social risks were associated with days at home, defined as the number of days spent outside inpatient, long-term care, observation, or emergency department settings over a 12-month period, using a negative binomial regression model.

Results

Not having a partner, not being employed, experiencing transportation barriers, and low medical literacy were respectively associated with 2.57, 3.18, 3.39, and 6.14 fewer days at home (i.e., 27% more facility days, 95% confidence interval [CI] 8%–50%; 42% more facility days, 95% CI 7%–89%; 34% more facility days, 95% CI 7%–68%; and 63% more facility days, 95% CI 27%–109%). Experiencing food insecurity was associated with 2.62 more days at home (i.e., 24% fewer facility days, 95% CI 3%–59%).

Conclusions

Findings suggest that screening older Veterans at high risk of community exit for social risks (i.e., social support, material resources, and medical literacy) may help identify patients likely to benefit from home- and community-based health and social services that facilitate remaining in home settings. Future research should focus on understanding the mechanisms by which these associations occur.

背景:许多医疗系统都在努力帮助老年人尽可能长时间地留在家中。人们对患者报告的社会风险与居家时间长短之间的关系知之甚少。我们评估了一组有住院和死亡高风险的老年退伍军人的社会风险与在家天数之间的关系:这是一项前瞻性横断面研究,使用了 2018 年对 3479 名年龄≥65 岁的高风险退伍军人进行的调查,该调查与退伍军人健康管理局的数据相链接。社会风险包括社会资源(即没有伴侣、社会支持度低)、物质资源(即没有工作、经济紧张、用药不安全、食品不安全和交通障碍)和个人资源(即医疗知识水平低和高中以下教育程度)的测量。我们使用负二项回归模型估算了社会风险与在家天数的关系,在家天数是指 12 个月内在住院、长期护理、观察或急诊室之外度过的天数:没有伴侣、没有工作、交通不便和医疗知识水平低分别导致在家天数减少 2.57 天、3.18 天、3.39 天和 6.14 天(即住院天数增加 27%,95% 置信区间 [CI]为 8%-50%;住院天数增加 42%,95% 置信区间为 7%-89%;住院天数增加 34%,95% 置信区间为 7%-68%;住院天数增加 63%,95% 置信区间为 27%-109%)。粮食不安全与在家天数增加 2.62 天有关(即设施天数减少 24%,95% CI 3%-59%):研究结果表明,对退出社区风险较高的老年退伍军人进行社会风险(即社会支持、物质资源和医疗知识)筛查,可帮助识别出可能受益于以家庭和社区为基础的健康和社会服务的患者,从而帮助他们留在家中。未来的研究应侧重于了解这些关联的发生机制。
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引用次数: 0
A scoping review of geriatric emergency medicine research transparency in diversity, equity, and inclusion reporting 老年急诊医学研究在多样性、公平性和包容性报告方面透明度的范围审查。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-12 DOI: 10.1111/jgs.19052
Anita N. Chary MD PhD, Michelle Suh MD, Edgardo Ordoñez MD, Lauren Cameron-Comasco MD, Surriya Ahmad MD, Alexander Zirulnik MD, MPH, Angela Hardi MLIS, AHIP, Alden Landry MD, Vivian Ramont MPH, Tracey Obi MPH, Emily H. Weaver PhD, Christopher R. Carpenter MD

Introduction

The intersection of ageism and racism is underexplored in geriatric emergency medicine (GEM) research.

Methods

We performed a scoping review of research published between January 2016 and December 2021. We included original emergency department-based research focused on falls, delirium/dementia, medication safety, and elder abuse. We excluded manuscripts that did not include (1) original research data pertaining to the four core topics, (2) older adults, (3) subjects from the United States, and (4) for which full text publication could not be obtained. The primary objective was to qualitatively describe reporting about older adults' social identities in GEM research. Secondary objectives were to describe (1) the extent of inclusion of minoritized older adults in GEM research, (2) GEM research about health equity, and (3) feasible approaches to improve the status quo of GEM research reporting.

Results

After duplicates were removed, 3277 citations remained and 883 full-text articles were reviewed, of which 222 met inclusion criteria. Four findings emerged. First, race and ethnicity reporting was inconsistent. Second, research rarely provided a rationale for an age threshold used to define geriatric patients. Third, GEM research more commonly reported sex than gender. Fourth, research commonly excluded older adults with cognitive impairment and speakers of non-English primary languages.

Conclusion

Meaningful assessment of GEM research inclusivity is limited by inconsistent reporting of sociodemographic characteristics, specifically race and ethnicity. Reporting of sociodemographic characteristics should be standardized across different study designs. Strategies are needed to include in GEM research older adults with cognitive impairment and non-English primary languages.

导言:老年急诊医学(GEM)研究中对年龄歧视和种族主义的交集探讨不足:我们对 2016 年 1 月至 2021 年 12 月间发表的研究进行了范围界定。方法:我们对 2016 年 1 月至 2021 年 12 月间发表的研究进行了范围界定,其中包括基于急诊科的原创研究,重点关注跌倒、谵妄/痴呆、用药安全和虐待老人。我们排除了不包括以下内容的稿件:(1)与四个核心主题相关的原创研究数据;(2)老年人;(3)来自美国的研究对象;(4)无法获得全文发表的稿件。首要目标是对 GEM 研究中有关老年人社会身份的报告进行定性描述。次要目标是描述:(1) 少数族裔老年人参与 GEM 研究的程度;(2) 有关健康公平的 GEM 研究;(3) 改善 GEM 研究报告现状的可行方法:结果:在删除重复文章后,还剩下 3277 篇引文和 883 篇全文文章,其中 222 篇符合纳入标准。有四项发现。首先,种族和民族报告不一致。其次,很少有研究对界定老年患者的年龄阈值提供理由。第三,GEM 研究更多报告的是性别而非性别。第四,研究通常不包括有认知障碍和使用非英语母语的老年人:结论:对 GEM 研究的包容性进行有意义的评估受到了社会人口特征(特别是种族和民族)报告不一致的限制。在不同的研究设计中,社会人口特征的报告应该标准化。需要制定策略,将有认知障碍和非英语母语的老年人纳入 GEM 研究。
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引用次数: 0
Peripheral neuropathy, gait speed, and lower extremity function in community-dwelling older adults with and without diabetes 患有和未患有糖尿病的社区老年人的周围神经病变、步速和下肢功能。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-12 DOI: 10.1111/jgs.19072
Katherine M. McDermott MD, Dan Wang MS, B. Gwen Windham MD, MHS, Jennifer A. Schrack PhD, MS, Elizabeth Selvin PhD, MPH, Caitlin W. Hicks MD, MS
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引用次数: 0
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Journal of the American Geriatrics Society
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