Theresa J. Langlois DVM, Alicia Mastrocco DVM, DACVECC, Jennifer E. Prittie DVM, DACVIM, DACVECC, Joel G. Weltman DVM, PhD, DACVECC
Objective
To assess the value of the abdominal fluid score (AFS) in cats following trauma in determining surgical needs, transfusion needs, and mortality.
Design
Multicenter retrospective observational study utilizing data from the Veterinary Committee on Trauma (VetCOT) registry.
Setting
VetCOT Veterinary Trauma Centers.
Animals
A total of 2309 cats entered into the VetCOT registry between January 1, 2013, and December 31, 2020, were included.
Interventions
None.
Measurements and Main Results
Of the included cats, 148 had abdominal effusion on presentation (AFS 1–4, positive AFS [pAFS]). pAFS cats demonstrated a lower total plasma protein (6.2 g/dL, range: 2.8–9.2 g/dL vs 6.8 g/dL, range: 2.6–11 g/dL, P < 0.001) and a more negative base excess (BE) (−9, range: −23.7 to 10 vs −6.1, range: −31.7 to 1, P = 0.001) than cats without abdominal effusion (negative AFS [nAFS]). pAFS cats also had a higher baseline Animal Trauma Triage score (ATTS) than nAFS cats (5, range 0–12 vs 3, range 0–17, respectively, P < 0.001). pAFS cats were more likely to require blood transfusions (16% [23/148] vs 4% [94/2161], P < 0.001) than nAFS cats, but need for surgical intervention did not differ between groups. A pAFS was associated with increased need for hospitalization (62.8% [93/148] vs 47.7% [1030/2160], P < 0.001), but length of hospital stay did not differ. Cats with pAFS experienced higher mortality compared to nAFS cats (42.6% [63/148] vs 22.7% [491/2161], P < 0.001).
Conclusion
The presence of abdominal effusion in cats following trauma was associated with increased morbidity in this study, as demonstrated by greater need for transfusion, increased likelihood of hospitalization, and greater mortality. Cats in the pAFS group had more negative BE and higher ATTS, but need for surgery, length of hospitalization, PCV, and blood glucose, plasma lactate, and ionized calcium concentrations were not different between groups.
目的：评估创伤后猫腹部液体评分（AFS）在确定手术需求、输血需求和死亡率方面的价值。设计：多中心回顾性观察研究，利用兽医创伤委员会（VetCOT）登记的数据。地点：VetCOT兽医创伤中心。动物：2013年1月1日至2020年12月31日期间，共有2309只猫进入了VetCOT登记处。干预措施:没有。测量结果和主要结果：纳入的猫中，148只猫出现腹部积液（AFS 1-4， AFS阳性[pas]）。pAFS猫表现出较低的总血浆蛋白（6.2 g/dL，范围：2.8-9.2 g/dL vs 6.8 g/dL，范围：2.6-11 g/dL）， P结论：在本研究中，创伤后猫腹部积液的存在与发病率增加有关，如输血需求增加、住院可能性增加和死亡率增加。pAFS组的猫有更多的负BE和更高的ATTS，但手术需求、住院时间、PCV、血糖、血浆乳酸和电离钙浓度在两组之间没有差异。
{"title":"Abdominal fluid score as a predictor of transfusion needs and outcome in cats following trauma","authors":"Theresa J. Langlois DVM, Alicia Mastrocco DVM, DACVECC, Jennifer E. Prittie DVM, DACVIM, DACVECC, Joel G. Weltman DVM, PhD, DACVECC","doi":"10.1111/vec.13437","DOIUrl":"10.1111/vec.13437","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the value of the abdominal fluid score (AFS) in cats following trauma in determining surgical needs, transfusion needs, and mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Multicenter retrospective observational study utilizing data from the Veterinary Committee on Trauma (VetCOT) registry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>VetCOT Veterinary Trauma Centers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>A total of 2309 cats entered into the VetCOT registry between January 1, 2013, and December 31, 2020, were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>None.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>Of the included cats, 148 had abdominal effusion on presentation (AFS 1–4, positive AFS [pAFS]). pAFS cats demonstrated a lower total plasma protein (6.2 g/dL, range: 2.8–9.2 g/dL vs 6.8 g/dL, range: 2.6–11 g/dL, <i>P</i> < 0.001) and a more negative base excess (BE) (−9, range: −23.7 to 10 vs −6.1, range: −31.7 to 1, <i>P</i> = 0.001) than cats without abdominal effusion (negative AFS [nAFS]). pAFS cats also had a higher baseline Animal Trauma Triage score (ATTS) than nAFS cats (5, range 0–12 vs 3, range 0–17, respectively, <i>P</i> < 0.001). pAFS cats were more likely to require blood transfusions (16% [23/148] vs 4% [94/2161], <i>P</i> < 0.001) than nAFS cats, but need for surgical intervention did not differ between groups. A pAFS was associated with increased need for hospitalization (62.8% [93/148] vs 47.7% [1030/2160], <i>P</i> < 0.001), but length of hospital stay did not differ. Cats with pAFS experienced higher mortality compared to nAFS cats (42.6% [63/148] vs 22.7% [491/2161], <i>P</i> < 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The presence of abdominal effusion in cats following trauma was associated with increased morbidity in this study, as demonstrated by greater need for transfusion, increased likelihood of hospitalization, and greater mortality. Cats in the pAFS group had more negative BE and higher ATTS, but need for surgery, length of hospitalization, PCV, and blood glucose, plasma lactate, and ionized calcium concentrations were not different between groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"28-33"},"PeriodicalIF":1.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pen-Ting Liao DVM, MVM, DVSc, DACVAA, DACVECC, William Raivs BS, PhD, Stuart Clark-Price DVM, MS, DACVAA, DACVIM, Katherine Gerken DVM, MS, DACVECC, Sue Duran RPH, MS, PhD, DICVP
Objective
To investigate the volume kinetic between 2 crystalloid fluid bolus rates in anesthetized cats.
Design
Prospective, randomized, dose–response study.
Setting
University laboratory.
Animals
Ten convenience-sample, purpose-bred domestic shorthair and medium hair cats.
Interventions
Intravenous 20 mL/kg balanced crystalloid fluid over 10 (G10) or 40 (G40) minutes under anesthesia in a randomized order with at least a 5-day washout period.
Measurements and Main Results
Serial measurements of hemoglobin (Hb) concentration and PCV were performed up to 60 minutes after conclusion of the fluid bolus. Plasma dilution was calculated with the Hb dilution method and fitted to a 2-compartment microconstant kinetic model using nonlinear mixed-effect models. The apparent central plasma volume (Vc) was similar between the 2 groups (G10: 81.2 ± 23.8 mL/kg and G40: 78.8 ± 10.2 mL/kg). The apparent peripheral volume (Vp) of G10 (4.81E+8 ± 2.66E+8 mL/kg) was twice that of G40 (2.36E+8 ± 6.44E+7 mL/kg). The rate constant from Vc to Vp (K12) of G10 (0.057 ± 0.0196/min) was almost twice that of G40 (0.0302 ± 0.00807/min). The elimination constant of G10 (0.0113 ± 0.00672/min) was almost twice that of G40 (0.00534 ± 0.00279/min). The peak plasma expansion was similar between G10 and G40 (20.7 ± 1.9 and 19.1 ± 5.1 mL/kg). Area under the curve for plasma dilution versus time of the first 90 minutes from the beginning of the boluses was not statistically different between G10 and G40.
Conclusions
The volume expansion over time was not different likely due to the slow elimination. The plasma dilution to crystalloid bolus between subjects is varied in anesthetized cats. Clinicians should consider the slow elimination and return of crystalloid fluid from the Vp to Vc when prescribing fluid therapy in anesthetized cats.
{"title":"Volume kinetic analysis of two crystalloid fluid bolus rates in anesthetized cats","authors":"Pen-Ting Liao DVM, MVM, DVSc, DACVAA, DACVECC, William Raivs BS, PhD, Stuart Clark-Price DVM, MS, DACVAA, DACVIM, Katherine Gerken DVM, MS, DACVECC, Sue Duran RPH, MS, PhD, DICVP","doi":"10.1111/vec.13449","DOIUrl":"10.1111/vec.13449","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the volume kinetic between 2 crystalloid fluid bolus rates in anesthetized cats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Prospective, randomized, dose–response study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>University laboratory.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Ten convenience-sample, purpose-bred domestic shorthair and medium hair cats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>Intravenous 20 mL/kg balanced crystalloid fluid over 10 (G10) or 40 (G40) minutes under anesthesia in a randomized order with at least a 5-day washout period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>Serial measurements of hemoglobin (Hb) concentration and PCV were performed up to 60 minutes after conclusion of the fluid bolus. Plasma dilution was calculated with the Hb dilution method and fitted to a 2-compartment microconstant kinetic model using nonlinear mixed-effect models. The apparent central plasma volume (<i>V</i><sub>c</sub>) was similar between the 2 groups (G10: 81.2 ± 23.8 mL/kg and G40: 78.8 ± 10.2 mL/kg). The apparent peripheral volume (<i>V</i><sub>p</sub>) of G10 (4.81E+8 ± 2.66E+8 mL/kg) was twice that of G40 (2.36E+8 ± 6.44E+7 mL/kg). The rate constant from <i>V</i><sub>c</sub> to <i>V</i><sub>p</sub> (<i>K</i><sub>12</sub>) of G10 (0.057 ± 0.0196/min) was almost twice that of G40 (0.0302 ± 0.00807/min). The elimination constant of G10 (0.0113 ± 0.00672/min) was almost twice that of G40 (0.00534 ± 0.00279/min). The peak plasma expansion was similar between G10 and G40 (20.7 ± 1.9 and 19.1 ± 5.1 mL/kg). Area under the curve for plasma dilution versus time of the first 90 minutes from the beginning of the boluses was not statistically different between G10 and G40.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The volume expansion over time was not different likely due to the slow elimination. The plasma dilution to crystalloid bolus between subjects is varied in anesthetized cats. Clinicians should consider the slow elimination and return of crystalloid fluid from the <i>V</i><sub>p</sub> to <i>V</i><sub>c</sub> when prescribing fluid therapy in anesthetized cats.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"41-51"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victoria N. P. Kastenholz DVM, Jacob Wolf DVM, DACVECC, Christa L. Bernhard DVM, MS, DACVECC, RRT
Objective
To describe a novel approach to tracheostomy management in dogs with upper airway trauma.
Case Series Summary
Two dogs with upper airway trauma presented to an emergency department and required immediate intubation. To minimize sedation time, tracheostomy tubes were placed in both dogs. A stepwise approach to decannulation was initiated, with both dogs receiving a 1-way speaking valve to facilitate a gradual approach to decannulation.
New or Unique Information Provided
This is the first report of a 1-way speaking valve being used in the management of tracheostomy tubes in dogs.
{"title":"A novel approach to decannulation of a tracheostomy tube using a 1-way speaking valve after upper airway trauma in 2 dogs","authors":"Victoria N. P. Kastenholz DVM, Jacob Wolf DVM, DACVECC, Christa L. Bernhard DVM, MS, DACVECC, RRT","doi":"10.1111/vec.13443","DOIUrl":"10.1111/vec.13443","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To describe a novel approach to tracheostomy management in dogs with upper airway trauma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Series Summary</h3>\u0000 \u0000 <p>Two dogs with upper airway trauma presented to an emergency department and required immediate intubation. To minimize sedation time, tracheostomy tubes were placed in both dogs. A stepwise approach to decannulation was initiated, with both dogs receiving a 1-way speaking valve to facilitate a gradual approach to decannulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> New or Unique Information Provided</h3>\u0000 \u0000 <p>This is the first report of a 1-way speaking valve being used in the management of tracheostomy tubes in dogs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"81-87"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cormac Dolan MVB, Neus Elias Santo-Domingo LMV, DECVECC
Objective
To report the occurrence of neutropenia in dogs with suspected acute hemorrhagic diarrhea syndrome (AHDS) and to assess its association with survival. Secondary objectives were to assess whether neutropenia was associated with length of hospitalization, fulfillment of systemic inflammatory response syndrome (SIRS) criteria, and whether SIRS status was associated with survival. Finally, the association of antimicrobial use with neutropenia, SIRS status, and survival was evaluated.
Design
Single-center, retrospective study from the medical records of dogs diagnosed with AHDS between 2017 and 2022.
Setting
Private referral hospital.
Animals
Fifty-four dogs with suspected AHDS referred to the Emergency and Critical Care specialist service.
Interventions
None.
Measurements and Main Results
Of 54 dogs, 28 (52%) presented with or developed neutropenia during their treatment course. Overall, 9 (17%) dogs were nonsurvivors. A total of 8 of 28 (29%) dogs with neutropenia were nonsurvivors, while only 1 of 26 (4%) dogs with a normal neutrophil count was a nonsurvivor (P = 0.025). Upon hospital admission, neutropenic dogs were significantly more likely to fulfill SIRS criteria than nonneutropenic dogs (P = 0.0096). There was no difference in mortality between SIRS-positive (fulfilling ≥2 SIRS criteria) and SIRS-negative (fulfilling <2 SIRS criteria) dogs (P = 0.14). There was no difference in the median length of hospitalization between neutropenic and nonneutropenic dogs (P = 0.49).
Conclusions
The incidence of neutropenia is high in this population of dogs presenting with AHDS. In this retrospective study, neutropenia was significantly associated with an increased risk of nonsurvival and an increased likelihood of fulfilling SIRS criteria; however, a fulfillment of SIRS criteria could not be used to predict survival. Neutropenia in dogs with AHDS was not associated with an increased length of hospitalization.
{"title":"Retrospective evaluation of the incidence and outcome of neutropenia in dogs with acute hemorrhagic diarrhea syndrome (2017–2022): 54 cases","authors":"Cormac Dolan MVB, Neus Elias Santo-Domingo LMV, DECVECC","doi":"10.1111/vec.13448","DOIUrl":"10.1111/vec.13448","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To report the occurrence of neutropenia in dogs with suspected acute hemorrhagic diarrhea syndrome (AHDS) and to assess its association with survival. Secondary objectives were to assess whether neutropenia was associated with length of hospitalization, fulfillment of systemic inflammatory response syndrome (SIRS) criteria, and whether SIRS status was associated with survival. Finally, the association of antimicrobial use with neutropenia, SIRS status, and survival was evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Single-center, retrospective study from the medical records of dogs diagnosed with AHDS between 2017 and 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Private referral hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Fifty-four dogs with suspected AHDS referred to the Emergency and Critical Care specialist service.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>None.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>Of 54 dogs, 28 (52%) presented with or developed neutropenia during their treatment course. Overall, 9 (17%) dogs were nonsurvivors. A total of 8 of 28 (29%) dogs with neutropenia were nonsurvivors, while only 1 of 26 (4%) dogs with a normal neutrophil count was a nonsurvivor (<i>P</i> = 0.025). Upon hospital admission, neutropenic dogs were significantly more likely to fulfill SIRS criteria than nonneutropenic dogs (<i>P</i> = 0.0096). There was no difference in mortality between SIRS-positive (fulfilling ≥2 SIRS criteria) and SIRS-negative (fulfilling <2 SIRS criteria) dogs (<i>P</i> = 0.14). There was no difference in the median length of hospitalization between neutropenic and nonneutropenic dogs (<i>P</i> = 0.49).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The incidence of neutropenia is high in this population of dogs presenting with AHDS. In this retrospective study, neutropenia was significantly associated with an increased risk of nonsurvival and an increased likelihood of fulfilling SIRS criteria; however, a fulfillment of SIRS criteria could not be used to predict survival. Neutropenia in dogs with AHDS was not associated with an increased length of hospitalization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"52-57"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabrina N. Hoehne Dr. med. vet., DACVECC, DECVECC, Julie A. Cary DVM, MS, DACVS, Post Grad Dipl Med Ed, CHSE, Lindsay N. Bailey BS, DVM, Elizabeth B. Davidow DVM, DACVECC, Linda G. Martin DVM, MS, DACVECC, Trey L. DeJong PhD
<div> <section> <h3> Objective</h3> <p>To evaluate the effect of rescuer team size on objective skill measures of basic life support (BLS) and advanced life support (ALS) using high-fidelity canine CPR simulation.</p> </section> <section> <h3> Design</h3> <p>Prospective, experimental study.</p> </section> <section> <h3> Setting</h3> <p>Veterinary clinical simulation center.</p> </section> <section> <h3> Subjects</h3> <p>Forty-eight Reassessment Campaign on Veterinary Resuscitation CPR-certified veterinary students.</p> </section> <section> <h3> Measurements and Main Results</h3> <p>Five groups of participants each conducted 3 CPR simulations in configurations of 4, 6, and 8 rescuers. Simulations represented a shock patient declining into asystole, followed by ventricular fibrillation and return of spontaneous circulation. Resuscitation efforts were video-recorded to evaluate BLS and ALS tasks. Mean (±SD) was derived and data were compared among team sizes using ANOVA and Tukey's post hoc analysis. Significance was set at <i>P</i> < 0.05. Among teams of 4, 6, and 8 rescuers, time to first chest compression (13 s [±6], 9 s [±2], 8 s [±4]; <i>P</i> = 0.24) and positive-pressure breath (101 s [±37], 56 s [±15], 67 s [±24]; <i>P</i> = 0.05) were not significantly different. Chest compression (100/min [±5], 108/min [±6], 107/min [±6]; <i>P</i> = 0.12) and ventilatory rates (9/min [±1], respectively, <i>P</i> = 0.52) were not significantly different. Time without chest compressions/total length of CPR was not significantly different (72 s [±16], 61 s [±16], 54 s [±8]; <i>P</i> = 0.15). Capnography and ECG monitoring were used by all teams. Time to first vasopressor administration was significantly different among team sizes (268 s [±70], 164 s [±65], 174 s [±34]; <i>P</i> = 0.04), with vasopressors being most quickly administered by teams of 6 rescuers. Time to electrical defibrillation was not significantly different (486 s [±45], 424 s [±22], 488 s [±181]; <i>P</i> = 0.57). Incorrect ALS interventions occurred in 60%, 0%, and 40% of CPR events in 4, 6, and 8 rescuer teams, respectively.</p> </section> <section> <h3> Conclusions</h3> <p>Although the achievement of BLS tasks was comparable in teams of 4 rescuers, teams of 6 rescuers may be preferable based on differences in the rate of guideline-incompliant treatments and ALS task efficiency. Teams of
目的：采用高保真犬心肺复苏术模拟，评价救援人员队伍规模对基本生命支持（BLS）和高级生命支持（ALS）客观技能指标的影响。设计：前瞻性实验研究。设置：兽医临床模拟中心。对象：48名经心肺复苏术认证的兽医学生。测量结果和主要结果：五组参与者分别在4、6和8名救援人员的配置下进行了3次心肺复苏模拟。模拟模拟了一个休克患者进入无搏停止状态，随后是心室颤动和自然循环的恢复。复苏过程录像，以评估BLS和ALS任务。采用方差分析（ANOVA）和事后分析（Tukey’s post hoc analysis）对团队规模的数据进行比较，得出平均值（±SD）。结论：尽管4名救援者团队在完成BLS任务方面具有可比性，但基于不符合指南的治疗率和ALS任务效率的差异，6名救援者团队可能更可取。8人的救援团队在执行BLS和ALS任务时既没有更高的效率，也没有更准确。
{"title":"An exploratory study on the effect of rescuer team size on basic and advanced life support technical skills in a high-fidelity simulation of canine cardiopulmonary arrest","authors":"Sabrina N. Hoehne Dr. med. vet., DACVECC, DECVECC, Julie A. Cary DVM, MS, DACVS, Post Grad Dipl Med Ed, CHSE, Lindsay N. Bailey BS, DVM, Elizabeth B. Davidow DVM, DACVECC, Linda G. Martin DVM, MS, DACVECC, Trey L. DeJong PhD","doi":"10.1111/vec.13445","DOIUrl":"10.1111/vec.13445","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the effect of rescuer team size on objective skill measures of basic life support (BLS) and advanced life support (ALS) using high-fidelity canine CPR simulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Prospective, experimental study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Veterinary clinical simulation center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Subjects</h3>\u0000 \u0000 <p>Forty-eight Reassessment Campaign on Veterinary Resuscitation CPR-certified veterinary students.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>Five groups of participants each conducted 3 CPR simulations in configurations of 4, 6, and 8 rescuers. Simulations represented a shock patient declining into asystole, followed by ventricular fibrillation and return of spontaneous circulation. Resuscitation efforts were video-recorded to evaluate BLS and ALS tasks. Mean (±SD) was derived and data were compared among team sizes using ANOVA and Tukey's post hoc analysis. Significance was set at <i>P</i> < 0.05. Among teams of 4, 6, and 8 rescuers, time to first chest compression (13 s [±6], 9 s [±2], 8 s [±4]; <i>P</i> = 0.24) and positive-pressure breath (101 s [±37], 56 s [±15], 67 s [±24]; <i>P</i> = 0.05) were not significantly different. Chest compression (100/min [±5], 108/min [±6], 107/min [±6]; <i>P</i> = 0.12) and ventilatory rates (9/min [±1], respectively, <i>P</i> = 0.52) were not significantly different. Time without chest compressions/total length of CPR was not significantly different (72 s [±16], 61 s [±16], 54 s [±8]; <i>P</i> = 0.15). Capnography and ECG monitoring were used by all teams. Time to first vasopressor administration was significantly different among team sizes (268 s [±70], 164 s [±65], 174 s [±34]; <i>P</i> = 0.04), with vasopressors being most quickly administered by teams of 6 rescuers. Time to electrical defibrillation was not significantly different (486 s [±45], 424 s [±22], 488 s [±181]; <i>P</i> = 0.57). Incorrect ALS interventions occurred in 60%, 0%, and 40% of CPR events in 4, 6, and 8 rescuer teams, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although the achievement of BLS tasks was comparable in teams of 4 rescuers, teams of 6 rescuers may be preferable based on differences in the rate of guideline-incompliant treatments and ALS task efficiency. Teams of ","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"9-18"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.13445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To prospectively compare the shock index (SI) in a population of healthy cats with a population of cats presenting to the emergency room (ER) deemed to be in a state of shock.
Design
Prospective cohort study of cats.
Setting
University teaching hospital.
Animals
Twenty-seven healthy control cats were enrolled to establish a reference interval, and 27 cats were enrolled that were presented to the ER with clinical signs of shock. Shock was defined as abnormalities in at least 2 of the following inclusion criteria: plasma lactate concentration > 2.5 mmol/L; peripheral vasoconstriction (at least 2 of the following parameters: capillary refill time >3 s, rectal-interdigital temperature gradient [RITG] >8°C, femoral pulse not palpable, pale mucous membranes); or systolic blood pressure (SBP) < 100 mm Hg.
Interventions
Upon presentation, SI (SI = heart rate [HR]/SBP), HR, SBP, and RITG were recorded in both groups, along with peripheral venous blood sampling for lactate measurement.
Measurements and Main Results
The mean SI in the control group was 1.47 ± 0.2 and was 1.87 ± 0.47 in the shock group (P = 0.001). Using equality in sensitivity and specificity of 0.7, an SI cutoff point of 1.54 (95% confidence interval [CI]: 0.49–0.86) was determined with an estimated area under the receiver operating characteristic curve of 0.78 (95% CI: 0.65–0.90). HR, plasma lactate concentration, and RITG did not differ between the groups. Systolic arterial blood pressure (P = 0.01), rectal temperature (P = 0.02), and interdigital temperature (P = 0.04) differed significantly.
Conclusions
The SI is a noninvasive, easy, and reliable parameter for distinguishing cats in shock from normal cats.
{"title":"Assessment of shock index in healthy cats and in cats presenting to an emergency room with shock","authors":"Leandro Fadel DVM, MSc, Rodrigo Cardoso Rabelo DVM, MSc, PhD, Denise Tabacchi Fantoni DVM, MSc, PhD, Gustavo Machado DMV, MSc, PhD, Marina Candido Duarte DVM, Gabriela da Cruz Schaefer DVM, MScv, Mariana Pires Oliveira DVM, MSc, Jessica de Oliveira Lara Castanheira Fadel DVM, MSc, Kamila dos Santos Morais DVM, Glaucia Bueno Pereira-Neto DVM, MSc, PhD, Fernanda Vieira Amorim da Costa DVM, MSc, PhD","doi":"10.1111/vec.13446","DOIUrl":"10.1111/vec.13446","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To prospectively compare the shock index (SI) in a population of healthy cats with a population of cats presenting to the emergency room (ER) deemed to be in a state of shock.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Prospective cohort study of cats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>University teaching hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Twenty-seven healthy control cats were enrolled to establish a reference interval, and 27 cats were enrolled that were presented to the ER with clinical signs of shock. Shock was defined as abnormalities in at least 2 of the following inclusion criteria: plasma lactate concentration > 2.5 mmol/L; peripheral vasoconstriction (at least 2 of the following parameters: capillary refill time >3 s, rectal-interdigital temperature gradient [RITG] >8°C, femoral pulse not palpable, pale mucous membranes); or systolic blood pressure (SBP) < 100 mm Hg.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>Upon presentation, SI (SI = heart rate [HR]/SBP), HR, SBP, and RITG were recorded in both groups, along with peripheral venous blood sampling for lactate measurement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>The mean SI in the control group was 1.47 ± 0.2 and was 1.87 ± 0.47 in the shock group (<i>P </i>= 0.001). Using equality in sensitivity and specificity of 0.7, an SI cutoff point of 1.54 (95% confidence interval [CI]: 0.49–0.86) was determined with an estimated area under the receiver operating characteristic curve of 0.78 (95% CI: 0.65–0.90). HR, plasma lactate concentration, and RITG did not differ between the groups. Systolic arterial blood pressure (<i>P</i> = 0.01), rectal temperature (<i>P</i> = 0.02), and interdigital temperature (<i>P</i> = 0.04) differed significantly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The SI is a noninvasive, easy, and reliable parameter for distinguishing cats in shock from normal cats.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"34-40"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ingrid Preteseille DVM, MSc, Steven E. Epstein DVM, DACVECC, Kate Hopper BVSc, PhD, DACVECC
Background
Venous blood gas and acid–base analysis is often performed in cats and requires appropriate reference intervals (RIs) for interpretation. The currently available RIs were created from small numbers of cats, while current guidelines suggest that a minimum number of 40 samples is required for the creation of an accurate/appropriate RI.
Key Findings
In 41 healthy awake cats, pH, PvCO2, PvO2, sodium, potassium, ionized calcium, chloride, glucose, and plasma lactate concentrations were measured, while bicarbonate, standardized base excess, and anion gap were calculated. These data were used to calculate RIs, using a statistical approach that conforms to the American Society for Veterinary Clinical Pathology guidelines.
Significance
RIs for venous blood gas and traditional acid–base analysis from a relatively large population of healthy cats are now available for clinical use and standardized for future research studies.
{"title":"Determination of reference intervals of venous blood gas and acid–base parameters in clinically healthy awake cats","authors":"Ingrid Preteseille DVM, MSc, Steven E. Epstein DVM, DACVECC, Kate Hopper BVSc, PhD, DACVECC","doi":"10.1111/vec.13441","DOIUrl":"10.1111/vec.13441","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Venous blood gas and acid–base analysis is often performed in cats and requires appropriate reference intervals (RIs) for interpretation. The currently available RIs were created from small numbers of cats, while current guidelines suggest that a minimum number of 40 samples is required for the creation of an accurate/appropriate RI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Findings</h3>\u0000 \u0000 <p>In 41 healthy awake cats, pH, P<sub>v</sub><span>CO</span><sub>2</sub>, P<sub>v</sub><span>O</span><sub>2</sub>, sodium, potassium, ionized calcium, chloride, glucose, and plasma lactate concentrations were measured, while bicarbonate, standardized base excess, and anion gap were calculated. These data were used to calculate RIs, using a statistical approach that conforms to the American Society for Veterinary Clinical Pathology guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Significance</h3>\u0000 \u0000 <p>RIs for venous blood gas and traditional acid–base analysis from a relatively large population of healthy cats are now available for clinical use and standardized for future research studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"92-95"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lindsay N. Cuddy DVM, Kate Hopper BVSc, PhD, DACVECC, Jamie M. Burkitt-Creedon DVM, Steven E. Epstein DVM, DACVECC
Objective
To describe the acid–base balance of diabetic animals with ketosis and to identify underlying mechanisms of acid–base changes using semiquantitative analysis.
Design
Retrospective study.
Setting
University teaching hospital.
Animals
Eighty-one client-owned dogs and 15 client-owned cats with diabetes and concurrent ketosis presented to a university teaching hospital.
Interventions
None.
Measurements and Main Results
The medical records database was searched from January 2017 through December 2021 for dogs and cats with diabetes mellitus and ketones present in urine or blood samples that also had venous blood gas and serum biochemical assays performed within 24 hours of each other. Traditional analysis identified normal acid–base status in 20% of dogs and 7% of cats. A simple metabolic acidosis with an elevated anion gap was observed in 17% of dogs and 20% of cats, and a metabolic alkalosis was present in 4% of dogs and 7% of cats. The semiquantitative approach identified metabolic acid–base disorders in all animals. One or more acidifying processes were evident in 100% of dogs and 100% of cats, 1 or more alkalotic processes in 93% of dogs and 100% of cats, concurrent alkalotic and acidotic processes in 85% of dogs and 100% of cats, and unmeasured anions in all cases.
Conclusions
Dogs and cats with diabetic ketosis can have variable and complex acid–base disorders that may be better recognized using semiquantitative analysis. Diagnostic criteria such as low pH or a high anion gap may prevent the clinical recognition of diabetic ketoacidosis.
{"title":"Retrospective evaluation of acid–base analysis in dogs and cats with diabetic ketosis (2017–2021): 96 cases","authors":"Lindsay N. Cuddy DVM, Kate Hopper BVSc, PhD, DACVECC, Jamie M. Burkitt-Creedon DVM, Steven E. Epstein DVM, DACVECC","doi":"10.1111/vec.13447","DOIUrl":"10.1111/vec.13447","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To describe the acid–base balance of diabetic animals with ketosis and to identify underlying mechanisms of acid–base changes using semiquantitative analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Retrospective study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>University teaching hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Eighty-one client-owned dogs and 15 client-owned cats with diabetes and concurrent ketosis presented to a university teaching hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>None.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>The medical records database was searched from January 2017 through December 2021 for dogs and cats with diabetes mellitus and ketones present in urine or blood samples that also had venous blood gas and serum biochemical assays performed within 24 hours of each other. Traditional analysis identified normal acid–base status in 20% of dogs and 7% of cats. A simple metabolic acidosis with an elevated anion gap was observed in 17% of dogs and 20% of cats, and a metabolic alkalosis was present in 4% of dogs and 7% of cats. The semiquantitative approach identified metabolic acid–base disorders in all animals. One or more acidifying processes were evident in 100% of dogs and 100% of cats, 1 or more alkalotic processes in 93% of dogs and 100% of cats, concurrent alkalotic and acidotic processes in 85% of dogs and 100% of cats, and unmeasured anions in all cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dogs and cats with diabetic ketosis can have variable and complex acid–base disorders that may be better recognized using semiquantitative analysis. Diagnostic criteria such as low pH or a high anion gap may prevent the clinical recognition of diabetic ketoacidosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"65-72"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To retrospectively compare and report vasopressor duration and mortality of septic dogs with hypotension refractory to vasopressor administration (presumed critical illness-related corticosteroid insufficiency [CIRCI]) treated with or without dexamethasone sodium phosphate (DxSP).
Design
Retrospective study (2017–2022).
Setting
Tertiary referral and teaching hospitals.
Animals
Sixty client-owned dogs with confirmed or presumed sepsis and vasopressor-resistant hypotension. Hypotension was defined as systolic arterial pressure < 90 mm Hg or MAP < 65 mm Hg. Vasopressor resistance was defined as hypotension despite therapy with moderate- to high-dose vasopressors (> 0.5 µg/kg/min of norepinephrine IV).
Interventions
None.
Measurements and Main Results
Twenty-six dogs received DxSP (DxSP group, 0.002–0.39 mg/kg IV, variable frequency), and 34 dogs did not receive a glucocorticoid (non-DxSP group). The median time to vasopressor discontinuation was 20 hours (interquartile range [IQR]: 21; n = 6) in the DxSP group and 27 hours (IQR: 11; n = 5) in the non-DxSP group. In the DxSP group, 23% (6/26) of dogs survived to discharge compared with 15% (5/34) of dogs in the non-DxSP group, which was not significantly different (relative risk: 0.90, 95% confidence interval: 0.70–1.16; P = 0.41). There was no significant difference between the 2 groups in time from vasopressor administration to weaning in dogs that survived to discharge (P = 0.43). The median time from steroid administration to vasopressor wean was 15 hours (IQR: 19; n = 6), and the median time from steroid administration to sustained normotension (a systolic blood pressure > 90 mm Hg or a MAP >65 mm Hg for at least 4 h) was 1 hour (IQR: 5; n = 11).
Conclusions
There was no association between DxSP therapy and survival, duration of vasopressor therapy, or time between steroid administration and discontinuation of vasopressor therapy in dogs being treated for sepsis, vasopressor resistance, and suspected CIRCI.
目的：回顾性比较和报道使用或不使用地塞米松磷酸钠（DxSP）治疗或不使用地塞米松磷酸钠（DxSP）治疗的感染性低血压犬（假定为危重性疾病相关性皮质类固醇功能不全[CIRCI]）抗利尿激素持续时间和死亡率。设计：回顾性研究（2017-2022）。环境：三级转诊医院和教学医院。动物：60只确诊或推测为败血症和血管加压剂抵抗性低血压的客户犬。低血压定义为收缩压< 90 mm Hg或MAP < 65 mm Hg。血管加压剂抵抗定义为尽管使用中至高剂量血管加压剂（降甲肾上腺素IV剂量0.5 μ g/kg/min）治疗，但仍存在低血压。干预措施：无。测量及主要结果：26只犬接受DxSP治疗（DxSP组，0.002 ~ 0.39 mg/kg IV，变频），34只犬未接受糖皮质激素治疗（非DxSP组）。血管加压素停药的中位时间为20小时(四分位数间距[IQR]: 21；n = 6)， 27小时(IQR: 11；n = 5)，非dxsp组。DxSP组23%（6/26）的狗存活出院，而非DxSP组15%（5/34）的狗存活出院，差异无统计学意义(相对危险度：0.90,95%可信区间：0.70-1.16；p = 0.41)。两组给药至存活犬断奶至出院时间差异无统计学意义（P = 0.43）。从类固醇给药到停用血管加压素的中位时间为15小时(IQR: 19；n = 6)，从类固醇给药到持续正常血压（收缩压bbb90 mm Hg或MAP bbb65 mm Hg持续至少4小时）的中位时间为1小时(IQR: 5；n = 11)。结论：DxSP治疗与脓毒症、血管加压素抵抗和疑似CIRCI治疗犬的生存、血管加压素治疗持续时间或类固醇给药和停止血管加压素治疗之间没有关联。
{"title":"Retrospective evaluation of dexamethasone for treatment of suspected critical illness-related corticosteroid insufficiency in dogs with septic shock (2017–2022): 60 cases","authors":"Destinee Gardiner DVM, Bradley Harris DVM, DACVECC","doi":"10.1111/vec.13444","DOIUrl":"10.1111/vec.13444","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To retrospectively compare and report vasopressor duration and mortality of septic dogs with hypotension refractory to vasopressor administration (presumed critical illness-related corticosteroid insufficiency [CIRCI]) treated with or without dexamethasone sodium phosphate (DxSP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Retrospective study (2017–2022).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Tertiary referral and teaching hospitals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Sixty client-owned dogs with confirmed or presumed sepsis and vasopressor-resistant hypotension. Hypotension was defined as systolic arterial pressure < 90 mm Hg or MAP < 65 mm Hg. Vasopressor resistance was defined as hypotension despite therapy with moderate- to high-dose vasopressors (> 0.5 µg/kg/min of norepinephrine IV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interventions</h3>\u0000 \u0000 <p>None.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Main Results</h3>\u0000 \u0000 <p>Twenty-six dogs received DxSP (DxSP group, 0.002–0.39 mg/kg IV, variable frequency), and 34 dogs did not receive a glucocorticoid (non-DxSP group). The median time to vasopressor discontinuation was 20 hours (interquartile range [IQR]: 21; <i>n </i>= 6) in the DxSP group and 27 hours (IQR: 11; <i>n</i> = 5) in the non-DxSP group. In the DxSP group, 23% (6/26) of dogs survived to discharge compared with 15% (5/34) of dogs in the non-DxSP group, which was not significantly different (relative risk: 0.90, 95% confidence interval: 0.70–1.16; <i>P </i>= 0.41). There was no significant difference between the 2 groups in time from vasopressor administration to weaning in dogs that survived to discharge (<i>P </i>= 0.43). The median time from steroid administration to vasopressor wean was 15 hours (IQR: 19; <i>n</i> = 6), and the median time from steroid administration to sustained normotension (a systolic blood pressure > 90 mm Hg or a MAP >65 mm Hg for at least 4 h) was 1 hour (IQR: 5; <i>n</i> = 11).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There was no association between DxSP therapy and survival, duration of vasopressor therapy, or time between steroid administration and discontinuation of vasopressor therapy in dogs being treated for sepsis, vasopressor resistance, and suspected CIRCI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 1","pages":"58-64"},"PeriodicalIF":1.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Issue Information - Prelim","authors":"","doi":"10.1111/vec.13308","DOIUrl":"https://doi.org/10.1111/vec.13308","url":null,"abstract":"","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"34 6","pages":"511-514"},"PeriodicalIF":1.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.13308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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