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Auger Electron Spectroscopy for Chemical Analysis of Passivated (Al,Ga)N-Based Systems. 钝化(Al,Ga) n基体系化学分析的俄歇电子能谱。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010047
Alina Domanowska, Bogusława Adamowicz

This review summarizes the use of Auger Electron Spectroscopy (AES) for microchemical analysis of two different types of dielectric/(Al,Ga)N-based systems: (i) extrinsic dielectric PECVD SiO2, ALD Al2O3, and ECR-CVD SiNx films on AlxGa1-xN/GaN structures in the context of their application in microelectronic power devices and (ii) intrinsic Al2O3 films on AlN epitaxial layers grown by high-temperature oxidation for nanostructured technology of various gas/ion sensors. Particular attention is given to AES depth profiling across complete multilayer cross-sections, combining qualitative analysis of spectral line shape and intensity evolution as well as kinetic energy shifts with quantitative elemental depth distributions. This approach enables identification of chemical states and oxidation-related transformations at dielectric/semiconductor interfaces. Reported results demonstrate that AES provides micro- to nanometer-scale chemical information essential for distinguishing interfacial from the bulk properties. The capabilities and inherent limitations of AES depth profiling, including sputter-induced artifacts are also addressed, highlighting the role of optimized experimental conditions in reliable interface analysis.

本文综述了利用埃格电子能谱(AES)对两种不同类型的介电/(Al,Ga) n基体系进行微化学分析的方法:(i)外源性介电PECVD SiO2、ALD Al2O3和ECR-CVD SiNx薄膜在AlxGa1-xN/GaN结构上的应用及其在微电子功率器件中的应用;(ii)高温氧化生长的AlN外延层上的本征Al2O3薄膜用于各种气体/离子传感器的纳米结构技术。特别注意的是AES深度剖面在完整的多层截面上,结合定性分析谱线形状和强度演变以及动能转移与定量元素深度分布。这种方法可以识别电介质/半导体界面上的化学状态和氧化相关转变。报道的结果表明,AES提供了区分界面和体性质所必需的微到纳米尺度的化学信息。本文还讨论了AES深度剖面的能力和固有局限性,包括溅射引起的伪影,强调了优化实验条件在可靠界面分析中的作用。
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引用次数: 0
Radio-Frequency Characteristics of Stacked Metal-Insulator-Metal Capacitors in Radio-Frequency CMOS Devices. 射频CMOS器件中堆叠金属-绝缘体-金属电容器的射频特性。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010054
Tae Min Choi, Hwa Rim Lee, Sung Gyu Pyo

This paper describes the radio-frequency (RF) characteristics of stacked metal-insulator-metal (MIM) capacitors used in RF CMOS technology. To ensure accurate analysis, various de-embedding methods for stacked MIM capacitors were verified, and an improved RF model was constructed accordingly. To develop an equivalent circuit for the improved RF model by analyzing the RF characteristics of stacked MIM capacitors, we compared de-embedding methods for measured stacked MIM capacitors: one-step (open-pattern or short-pattern) de-embedding and two-step (combined open-pattern and short-pattern) de-embedding. For the analysis of stacked MIM capacitors, at least two-step de-embedding was used, while for precise de-embedding, three-step de-embedding using a thru pattern was employed. Based on the measured values obtained using these two-step de-embedding methods, a modified equivalent circuit was constructed. This circuit was analyzed based on various parameters, including MIM capacitance, quality factor, S-parameter, and Y-parameter, and the results were comparatively examined. The findings highlight outstanding accuracy of the modified model, which is maintained even in high frequency bands.

本文介绍了射频CMOS技术中使用的金属-绝缘体-金属(MIM)堆叠电容器的射频特性。为了保证分析的准确性,验证了各种叠置MIM电容器的去嵌入方法,并据此构建了改进的射频模型。通过分析堆叠式MIM电容器的射频特性,为改进的射频模型开发等效电路,我们比较了测量的堆叠式MIM电容器的反埋入方法:一步(开路或短路)反埋入和两步(开路和短路联合)反埋入。对于层叠式MIM电容器的分析,至少采用了两步解嵌法,而对于精确解嵌法,则采用了三步透孔法。基于两步去嵌入方法得到的测量值,构造了改进的等效电路。对该电路进行了MIM电容、品质因数、s参数、y参数等参数的分析,并对结果进行了比较检验。这些发现突出了改进模型的出色准确性,即使在高频段也能保持这种准确性。
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引用次数: 0
Examination of Impact of NBTIs on Commercial Power P-Channel VDMOS Transistors in Practical Applications. nbti在实际应用中对商用功率p沟道VDMOS晶体管影响的研究。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010052
Danijel Danković, Emilija Živanović, Nevena Veselinović, Dunja Đorđević, Marija Petrović, Lana Tasić, Miloš Marjanović, Sandra Veljković, Nikola Mitrović, Vojkan Davidović, Goran Ristić

In this paper, the impact of negative bias temperature instabilities (NBTIs) on commercial power p-channel Vertical Double-Diffused MOS (VDMOS) transistors from the standpoint of practical applications was analyzed. The effects of NBTI are one of the main reliability concerns for this type of device, so it is necessary to investigate how these effects influence various applications. A series of experiments were carried out including negative bias temperature stressing, infra-red thermographic recording and circuit characterization, with the goal of evaluating the effects of negative bias temperature stressing on the self-heating of samples in load-driving circuits operating with higher currents and circuit performance of a CMOS inverter circuit containing the examined samples. The findings suggest that negative bias temperature stressing-induced threshold voltage shift directly affects increased self-heating in load-driving circuits and that it also directly affects transfer and dynamics characteristics in CMOS inverters.

本文从实际应用的角度分析了负偏置温度不稳定性(nbti)对商用功率p沟道垂直双扩散MOS (VDMOS)晶体管的影响。NBTI的影响是这类器件的主要可靠性问题之一,因此有必要研究这些影响如何影响各种应用。通过负偏置温度应力、红外热像记录和电路表征等一系列实验,评估了负偏置温度应力对负载驱动电路中样品自热的影响,以及含所测样品的CMOS逆变电路的电路性能。研究结果表明,负偏置温度应力引起的阈值电压漂移直接影响负载驱动电路中自热的增加,并直接影响CMOS逆变器的传递和动态特性。
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引用次数: 0
Hardware Accelerators for Cardiovascular Signal Processing: A System-on-Chip Perspective. 心血管信号处理的硬件加速器:片上系统的观点。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010051
Rami Hariri, Marcian Cirstea, Mahdi Maktab Dar Oghaz, Khaled Benkrid, Oliver Faust

This study presents a comprehensive systematic analysis, investigating hardware accelerators specifically designed for real-time cardiovascular signal processing, focusing mainly on Electrocardiogram (ECG), Photoplethysmogram (PPG), and blood pressure monitoring systems. Cardiovascular Diseases (CVDs) represent the world's leading cause of morbidity and mortality, creating an urgent demand for efficient and accurate diagnostic technologies. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically analysed 59 research papers on this topic, published from 2014 to 2024, categorising them into three main categories: signal denoising, feature extraction, and decision support with Machine Learning (ML) or Deep Learning (DL). A comprehensive performance benchmarking across energy efficiency, processing speed, and clinical accuracy demonstrates that hybrid Field Programmable Gate Array (FPGA)-Application Specific Integrated Circuit (ASIC) architectures and specialised Artificial Intelligence (AI) on Edge accelerators represent the most promising solutions for next-generation CVD monitoring systems. The analysis identifies key technological gaps and proposes future research directions focused on developing ultra-low-power, clinically robust, and highly scalable physiological signal processing systems. The findings provide guidance for advancing hardware-accelerated cardiovascular diagnostics toward practical clinical deployment.

本研究进行了全面的系统分析,研究了专门设计用于实时心血管信号处理的硬件加速器,主要集中在心电图(ECG),光电体积描记图(PPG)和血压监测系统。心血管疾病(cvd)是世界上发病率和死亡率的主要原因,迫切需要有效和准确的诊断技术。根据系统评价和元分析的首选报告项目(PRISMA)指南,我们系统地分析了2014年至2024年发表的关于该主题的59篇研究论文,将它们分为三大类:信号去噪、特征提取和机器学习(ML)或深度学习(DL)的决策支持。在能效、处理速度和临床准确性方面的综合性能基准测试表明,现场可编程门阵列(FPGA)-专用集成电路(ASIC)架构和专用人工智能(AI)边缘加速器的混合代表了下一代心血管疾病监测系统最有前途的解决方案。该分析确定了关键的技术差距,并提出了未来的研究方向,重点是开发超低功耗、临床鲁棒性和高度可扩展的生理信号处理系统。研究结果为硬件加速心血管诊断向实际临床部署的推进提供了指导。
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引用次数: 0
A Novel Fabric Strain Sensor Array with Hybrid Deep Learning for Accurate Knee Movement Recognition. 基于混合深度学习的织物应变传感器阵列准确识别膝关节运动。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010056
Tao Chen, Xiaobin Chen, Fei Wang

This paper presents a novel lightweight fabric strain sensor array specifically designed for comprehensive knee joint monitoring. The sensor system features a unique two-layer design incorporating eight strategically positioned sensing elements, enabling effective spatial mapping of strain distribution across the knee during movement. This configuration offers advantages in capturing complex multi-axis kinematics (flexion/extension, rotation) and localized tissue deformation when compared to simpler sensor layouts. To evaluate the system, ten subjects performed three distinct activities (seated leg raise, standing, walking), generating resistance data from the sensors. A hybrid deep learning model (CNN + BiLSTM + Attention) processed the data and significantly improved performance to 95%. This enhanced accuracy is attributed to the model's ability to extract spatial-temporal features and leverage long-term dependencies within the time-series sensor data. Furthermore, channel attention analysis within the deep learning model identified sensors 2, 4, and 6 as major contributors to classification performance. The results demonstrate the feasibility of the proposed fabric sensor array for accurately recognizing fundamental knee movements. Despite limitations in the diversity of postures, this system holds significant promise for future applications in rehabilitation monitoring, sports science analytics, and personalized healthcare within the medical and athletic domains.

本文提出了一种专为膝关节综合监测而设计的新型轻质织物应变传感器阵列。传感器系统具有独特的两层设计,包含八个战略性定位的传感元件,能够在运动过程中有效地绘制整个膝盖的应变分布空间。与简单的传感器布局相比,这种配置在捕获复杂的多轴运动学(屈/伸,旋转)和局部组织变形方面具有优势。为了评估该系统,10名受试者进行了三种不同的活动(坐着抬腿、站立、行走),从传感器产生阻力数据。混合深度学习模型(CNN + BiLSTM + Attention)处理数据,并将性能显著提高到95%。这种精度的提高归功于模型提取时空特征和利用时间序列传感器数据中的长期依赖关系的能力。此外,深度学习模型中的通道注意力分析将传感器2、4和6确定为分类性能的主要贡献者。实验结果验证了织物传感器阵列准确识别膝关节基本运动的可行性。尽管姿势的多样性存在局限性,但该系统在未来的康复监测、运动科学分析和医疗和运动领域的个性化医疗保健方面有着重要的应用前景。
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引用次数: 0
Design of a Bandgap Reference with a High PSRR and Strong Load-Driving Capability. 具有高PSRR和强负载驱动能力的带隙基准的设计。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010050
Meng Li, Lei Guo, Bin Liu, Lin Qi, Binghui He, Yu Cao, Jian Ren

This paper introduces an enhanced bandgap reference (BGR) design, addressing the shortcomings of traditional circuits, such as significant temperature drift, limited power-supply rejection, and inadequate load-driving capacity. The proposed design incorporates a symmetric folded common-emitter-common-base BJT amplifier with MOS-assisted biasing, employed in the proposed BGR, enforcing branch voltage symmetry to effectively suppress intrinsic offset caused by structural mismatch. By reducing the amplifier input offset, the circuit achieves improved reference voltage stability, a lower temperature coefficient (TC), and an enhanced power-supply rejection ratio (PSRR). Additionally, a negative-feedback adaptive current-adjustment driver is implemented to dynamically adjust the output current in response to real-time load changes. This method bolsters the load-driving capability and maintains a stable reference output across varying load conditions. The circuit was simulated using a 0.18 μm BCD process, revealing that with a 3.3 V supply voltage, the BGR produces a stable output voltage of 2.5 V, with a TC of 2.372×10-6 °C-1. The simulated PSRR is -114.2 dB at DC and -62.07 dB at 1 kHz. Moreover, under a 3.3 V supply, sweeping the load capacitance from 0.1 μF to 100 μF demonstrates that the reference voltage remains consistently regulated at 2.5 V, confirming its excellent load tolerance and output stability.

本文介绍了一种增强型带隙参考(BGR)设计,解决了传统电路的缺点,如明显的温度漂移、有限的电源抑制和负载驱动能力不足。所提出的设计包含一个对称折叠共发射-共基BJT放大器,该放大器采用mos辅助偏置,用于所提出的BGR,增强支路电压对称性,有效抑制结构失配引起的固有偏移。通过减小放大器输入偏置,该电路实现了更高的参考电压稳定性、更低的温度系数(TC)和更高的电源抑制比(PSRR)。此外,还实现了负反馈自适应电流调节驱动,以动态调整输出电流以响应实时负载变化。这种方法增强了负载驱动能力,并在不同的负载条件下保持稳定的参考输出。采用0.18 μm的BCD工艺对电路进行了仿真,结果表明,在3.3 V的电源电压下,BGR可以产生2.5 V的稳定输出电压,TC为2.372×10-6°C-1。模拟的PSRR在直流时为-114.2 dB,在1khz时为-62.07 dB。此外,在3.3 V电源下,将负载电容从0.1 μF扫描到100 μF,表明参考电压始终保持在2.5 V,证实了其出色的负载容限和输出稳定性。
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引用次数: 0
Preparation of Self-Assembled Human Serum Albumin Nanoparticles Decorated with Trastuzumab as a Paclitaxel Delivery System. 曲妥珠单抗修饰的自组装人血清白蛋白纳米颗粒作为紫杉醇递送系统的制备。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010055
Alexa H Gonzalez-Posada, Yuliana Monsalve, Betty Lucy López, Ligia Sierra

This study reports the development of paclitaxel (PTX)-loaded human serum albumin (HSA) nanoparticles (NPs), surface-decorated with trastuzumab (TMAB), with potential applicability in HER2-oriented delivery. The NPs were obtained via thermally driven self-assembly followed by non-covalent antibody adsorption and they were characterized using Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and ζ-potential analysis. The drug association efficiency (%DAE), defined exclusively for PTX, was high for both HSA-PTX and HSA-PTX-TMAB NPs (96.4% and 98.2% w/w, respectively), with loading capacities (%LC) of 8.9% and 7.4%, respectively. TMAB decoration led to a modest increase in mean diameter and a reduction in surface charge, consistent with successful surface modification. Both formulations exhibited rapid early-phase PTX release followed by an apparent stabilization phase, with distinct kinetic behavior between HSA-PTX and HSA-PTX-TMAB NPs. Cytotoxicity in A549 cells after 18 h of exposure showed modest, non-differential effects consistent with controlled release and short-term assessment of non-specific toxicity. Overall, this thermally assembled albumin-based system provides a promising foundation for further evaluation of HER2-oriented PTX delivery.

本研究报道了紫杉醇(PTX)负载的人血清白蛋白(HSA)纳米颗粒(NPs)的开发,表面修饰曲妥珠单抗(TMAB),具有潜在的her2定向递送适用性。NPs通过热驱动自组装和非共价抗体吸附获得,并通过傅里叶变换红外光谱(FTIR)、动态光散射(DLS)和ζ电位分析对其进行了表征。HSA-PTX和HSA-PTX- tmab NPs的药物关联效率(%DAE)均较高(分别为96.4%和98.2% w/w),载药量(%LC)分别为8.9%和7.4%。TMAB修饰导致平均直径适度增加,表面电荷减少,与表面修饰成功一致。两种配方均表现出快速的早期PTX释放,随后是明显的稳定阶段,在HSA-PTX和HSA-PTX- tmab NPs之间具有不同的动力学行为。暴露18小时后,A549细胞的细胞毒性表现出适度的、无差异的影响,与控释和短期非特异性毒性评估一致。总的来说,这种基于白蛋白的热组装系统为进一步评估her2导向PTX给药提供了有希望的基础。
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引用次数: 0
Polishing of EB-PBF Ti6Al4V Vertical Surfaces with Semi-Melted Particle Characteristics Realized by Continuous Laser. 连续激光抛光EB-PBF Ti6Al4V半熔颗粒垂直表面
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010046
Xiaozhu Chen, Congyi Wu, Youmin Rong, Guojun Zhang, Yu Huang

Electron beam powder bed fusion (EB-PBF) Ti6Al4V often exhibits high vertical surface roughness, limiting its use in high-end applications. In this study, an infrared continuous-wave laser was applied to precisely polish the vertical surface. An orthogonal design identified the optimal condition as 10,400 kW/cm2 power density, 800 mm/s scanning speed, and one pass, achieving a minimum Sa of 0.24 μm and a 98.03% reduction compared with the as-built surface. To address the adhered semi-molten particle characteristics of EB-PBF sidewalls, a molten-pool-dynamics-based polishing model was developed and validated, yielding an error as low as 1.24%. Simulations indicate that power density governs the final morphology by controlling molten pool coverage, scanning speed affects polishing efficiency via thermocapillary force, and polishing time influences surface quality by triggering or avoiding melt splashing.

电子束粉末床熔合(EB-PBF) Ti6Al4V通常具有很高的垂直表面粗糙度,限制了其在高端应用中的使用。在本研究中,采用红外连续波激光对垂直表面进行精确抛光。通过正交设计确定了最佳条件为10400 kW/cm2功率密度,800 mm/s扫描速度,一次通过,最小Sa为0.24 μm,与成品表面相比降低了98.03%。为了解决EB-PBF侧壁粘附的半熔融颗粒特性,开发并验证了基于熔池动力学的抛光模型,误差低至1.24%。模拟结果表明,功率密度通过控制熔池覆盖率来控制最终形貌,扫描速度通过热毛细力影响抛光效率,抛光时间通过触发或避免熔体飞溅来影响表面质量。
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引用次数: 0
Flexible Three-Dimensional Stress Sensor for Embedded Monitoring of Solid Rocket Propellant. 固体火箭推进剂嵌入式监测柔性三维应力传感器。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-30 DOI: 10.3390/mi17010057
Yaoguang Shi, Xiaozhou Lü, Kai Ren, Wensong Zhu

Solid rocket motors (SRMs) play a pivotal role in space exploration owing to their reliability and high thrust-to-weight ratios. SRM propellant health monitoring is in critical demand owing to the complex operational scenarios throughout the entire life cycle of SRMs. To achieve in situ detection of three-dimensional stress, this study introduces a novel flexible three-dimensional stress sensor (FSS). First, a liquid metal pressure-sensing element with a variable cross-section was designed and numerically modeled. The performance of the FSS under different loading conditions was analyzed using finite element modeling. The sensing element prototype was fabricated using mold casting and liquid metal injection methods. The fabricated sensing-element prototype with an area ratio of 1:5 exhibited a sensitivity coefficient of 1.5%/kPa at a pressure of 300 kPa, a maximum hysteresis error of 3.98%, and a stability error of 0.17%. Finally, the FSS was developed by integrating multiple pressure-sensing elements and encapsulating the force-concentrating layers. The fabricated FSS prototype was characterized using simulated propellant experiments. Via comparison with the simulation results, the FSS was found to detect multiaxial stress differences when embedded within a propellant.

固体火箭发动机以其高可靠性和高推重比在空间探索中起着举足轻重的作用。由于SRM推进剂在整个生命周期内的复杂运行情况,对推进剂健康监测的需求非常迫切。为了实现三维应力的原位检测,本研究引入了一种新型柔性三维应力传感器(FSS)。首先,设计了一种变截面液态金属压敏元件,并对其进行了数值模拟。采用有限元模型分析了FSS在不同载荷条件下的性能。采用模具铸造和液态金属注射法制备了传感元件原型。在300 kPa压力下,面积比为1:5的传感元件原型的灵敏度系数为1.5%/kPa,最大迟滞误差为3.98%,稳定性误差为0.17%。最后,通过集成多个压力传感元件并封装力集中层来开发FSS。通过模拟推进剂实验对制备的FSS原型进行了表征。通过与仿真结果的比较,发现FSS能够探测到埋入推进剂时的多轴应力差异。
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引用次数: 0
Experimental Study on the Performance of Light-Controlled Ion Drag Pump Based on PLZT Ceramic. 基于PLZT陶瓷的光控离子拖泵性能实验研究。
IF 3 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Pub Date : 2025-12-29 DOI: 10.3390/mi17010045
Yujuan Tang, Yujie Shi, Zhen Lv, Zihao Guo, Xinjie Wang

Light-controlled ion drag pumps have attracted considerable interest in soft robotics, biomedical engineering, and microelectromechanical systems (MEMS) due to their non-contact energy supply and high spatiotemporal controllability of light. However, experimental studies on their pumping performance and influencing factors remain limited. This study integrates the photoelectric effect with field emission phenomena to design and fabricate a light-controlled ion drag pump using lanthanum-modified lead zirconate titanate (PLZT) ceramic. The light-controlled pump enables non-contact energy transfer and fluid transport via high-energy laser irradiation. A series of experiments systematically investigate its pumping performance and key influencing factors. Results indicate that optimizing electrode structure and fluid channel design, along with increased light intensity, significantly enhances pumping performance. This work provides fundamental design guidelines for the application of light-controlled ion drag pumps in microfluidics, flexible robotics, and microdevice thermal management.

光控离子拖泵由于其非接触式能量供应和光的高时空可控性而引起了软机器人、生物医学工程和微机电系统(MEMS)等领域的广泛关注。然而,对其泵送性能及其影响因素的实验研究仍然有限。本研究将光电效应与场发射现象相结合,利用镧修饰锆钛酸铅(PLZT)陶瓷设计并制造了光控离子拖泵。光控泵通过高能激光照射实现非接触式能量传递和流体输送。通过一系列实验系统地研究了其泵送性能及其关键影响因素。结果表明,优化电极结构和流体通道设计,增加光强,可以显著提高泵送性能。这项工作为光控离子拖泵在微流体、柔性机器人和微器件热管理中的应用提供了基本的设计指导。
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引用次数: 0
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