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Recent Advances in Synthesis and Applications of Organic Ionic Salts-based Sensor Arrays 有机离子盐传感器阵列的合成与应用研究进展
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-06-14 DOI: 10.2174/1570193x20666230614141728
H. Chopra, Pawanpreet Kaur, A. Parmar
Sensor arrays contain a group of sensors, improve observations with new dimensions, provide better estimations, and additional parameters in comparison to the individual selective sensor. The array-based sensing technique provides good performance to respond to various gaseous or liquid analytes. Room temperature ionic liquids (RTILs) (melting point <25oC) and Group of uniform materials based on organic salts (GUMBOS) (melting point =25-250oC) are organic ionic salts, composed of an oppositely charged pair of bulky organic cations and bulky organic/inorganic anion and shows interesting tunable physicochemical properties. In this review article, we will discuss the sensing performance of ILs- and GUMBOS-based sensor arrays. ILs-based sensor arrays have been used in electrochemical gas sensing, solvent discrimination, colorimetric gas sensing, sensing of organic compounds, optoelectronic sensing of vapors and solutions, and vapour sensing through IL/QCM systems. GUMBOS-based sensor arrays have been employed in vapour sensing through the GUMBOS/QCM method, detection, and discrimination of proteins.
传感器阵列包含一组传感器,用新的维度改进观测,提供更好的估计,以及与单个选择性传感器相比的附加参数。基于阵列的传感技术提供了对各种气体或液体分析物作出响应的良好性能。室温离子液体(RTIL)(熔点<25℃)和基于有机盐的均匀材料组(GUMBOS)(熔点=25-250℃)是有机离子盐,由一对带相反电荷的大体积有机阳离子和大体积有机/无机阴离子组成,并显示出有趣的可调物理化学性质。在这篇综述文章中,我们将讨论基于离子液体和GUMBOS的传感器阵列的传感性能。基于离子液体的传感器阵列已用于电化学气体传感、溶剂识别、比色气体传感、有机化合物传感、蒸汽和溶液的光电传感以及通过离子液体/质量控制系统的蒸汽传感。基于GUMBOS的传感器阵列已通过GUMBOS/QCM方法、蛋白质的检测和鉴别应用于蒸汽传感。
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引用次数: 0
Biginelli Reaction: A Multi-Component Type of Reaction and Synthetic Advancement in the Synthesis of Bioactive Dihydropyrimidinone Derivatives Biginelli反应:生物活性二氢嘧啶衍生物的多组分反应及合成进展
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-06-01 DOI: 10.2174/1570193x20666230601093704
Gopal L. Khatik, Ramesh Ambatwar, Vaibhav Gupta, Sumit Kumar
In synthetic and medicinal chemistry, multi-component reactions (MCRs) are considered an essential tool in synthesizing bioactive heterocyclic scaffolds. These reactions have been strategically used in drug discovery and development because of ease and economy.The current manuscript aims to highlight the importance of the Biginelli reaction in the synthesis of diverse dihydropyrimidinones with medicinal applications.We searched various keywords, including “multicomponent reaction”, “Biginelli reaction” and “dihydropyrimidinone” on “PubMed, PubChem, and google scholar” and collected the relevant articles for including the current work.Biginelli reaction involving ketoester, aldehyde, and urea is a high-yielding, atom-economical, environmentally benign reaction for developing a library of new dihydropyrimidinones to drive the process of drug discovery. Several developments were achieved with modifications of synthetic techniques, including C-H activation, coupling, cycloaddition, etc. Inclusively, these modifications give access to a wide range of dihydropyrimidinones.
在合成和药物化学中,多组分反应(MCRs)被认为是合成具有生物活性的杂环支架的重要工具。这些反应由于简单和经济,已被战略性地用于药物的发现和开发。目前的手稿旨在强调Biginelli反应在合成具有药用应用的各种二氢嘧啶酮中的重要性。我们在“PubMed、PubChem和google scholar”上搜索了包括“多组分反应”、“Biginelli反应”和“二氢嘧啶酮”在内的各种关键词,并收集了包括当前工作的相关文章。涉及酮酯、醛和脲的Biginelli反应是一种高产、原子经济、环境友好的反应,用于开发新的二氢嘧啶酮库,以推动药物发现过程。通过对合成技术的修饰,包括C-H活化、偶联、环加成等,取得了一些进展。包括这些修饰,可以获得广泛的二氢嘧啶酮。
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引用次数: 0
Metal-based ionic liquids and solid-loaded catalysts in fuel oil desulfurization: A review 金属基离子液体和固体负载催化剂在燃料油脱硫中的研究进展
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-06-01 DOI: 10.2174/1570193x20666230601093152
Hang Xu, Anqi Niu, Qinlin Yuan, Fengmin Wu, Xuefeng Wei
Metal-based ionic liquids (MILs) have the advantages of designability, efficiency, stability, and regenerative cycle and can efficiently convert thiophene and its derivatives, which are important for the production of "ultra-low sulfur" oils. This paper provides an overview of the research progress of MILs in the field of fuel desulfurization, focusing on the current status of MILs and solid-loaded MILs catalysts in extractive desulfurization, oxidative desulfurization, extraction-catalyzed oxidative desulfurization, and catalytic-adsorption desulfurization processes. For MILs, the anion and cation can be altered by design so as to impart specific functions. Loading is one of the effective ways to solidify MILs, and the combination of MILs with different carriers can not only reduce the usage while ensuring the catalytic activity but also improve the reusability of the catalyst. The combination of MILs with specially structured carriers also allows solution-free adsorption and removal of oxidation products. Compared with conventional MILs, polymetallic-based ionic liquids (PMILs) exhibit ultra-high catalytic activity and are one of the most promising materials available, but are still in their infancy in the field of fuel catalysis, and researchers are needed to enrich the gap in this field. Finally, some problems faced by various types of MILs are pointed out in order to design new functional MILs catalysts with better properties in the future and promote the further development of MILs in the field of fuel catalysis.
金属基离子液体具有可设计性、高效性、稳定性和可再生循环等优点,能够高效地转化噻吩及其衍生物,对“超低硫”油的生产具有重要意义。本文综述了mil在燃料脱硫领域的研究进展,重点介绍了mil及其固体负载催化剂在萃取脱硫、氧化脱硫、萃取催化氧化脱硫和催化吸附脱硫等方面的研究现状。对于mil,阴离子和阳离子可以通过设计改变,以赋予特定的功能。负载是固化mil的有效方法之一,不同载体的mil组合在保证催化活性的同时减少用量,提高催化剂的可重复使用性。mil与特殊结构载体的结合也允许无溶液吸附和去除氧化产物。与传统离子液体相比,多金属基离子液体(PMILs)具有超高的催化活性,是目前最有前途的材料之一,但在燃料催化领域仍处于起步阶段,需要研究人员填补这一领域的空白。最后指出了各种类型的mil所面临的一些问题,以期在未来设计出性能更好的新型功能性mil催化剂,促进mil在燃料催化领域的进一步发展。
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引用次数: 0
Meet the Editorial Board Member 与编辑委员会成员见面
4区 化学 Q2 Chemistry Pub Date : 2023-06-01 DOI: 10.2174/1570193x2004230222122810
Roman Dembinski
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引用次数: 0
Chemistry and Biological Activity of Thieno[3,4-b] quinoline, Thieno[3,4-c] quinolone, Thieno[3,2-g] quinoline and Thieno[2,3-g] quinoline Derivatives: A Review (Part IX) Thieno[3,4-b]喹啉、Thieno[3,4-c]喹诺酮、Thieno[3,2-g]喹啉和Thieno[2,3-g]喹啉衍生物的化学和生物活性综述(第九部分)
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-06-01 DOI: 10.2174/1570193x20666230601151439
A. Abu‐Hashem, Ahmed A. M. Abdelgawad, M. Gouda
Over the previous decades, thieno-quinoline derivatives have acquired great interest due to their synthetic and biological applications. These reports have been disclosed on Thienoquinoline synthesis such as thieno[3,4-b]quinoline; thieno[3,4-c]quinolone; thieno [3,2-g]quinoline; thieno[2,3-g] quinoline; spiro-thieno[2,3-g]quinoline; benzo[b]thiophen-iso- quinoline derivatives, and therefore in the existent review, we provided an inclusive update on the synthesis of thienoquinolines. Characterization of the preparation methods and reactivity is categorized based on their types of reactions as addition, alkylation, chlorination, acylation, oxidation, reduction, cyclization and cyclo-condensation. Hence, this study will help the researchers to obtain knowledge from the last literature research to conquer their resolve problems in designing new compounds and processes.
在过去的几十年里,噻吩-喹啉衍生物由于其合成和生物应用而获得了极大的兴趣。目前已有关于噻吩喹啉合成的报道,如噻吩[3,4-b]喹啉;thieno[3上]喹诺酮;thieno [3, 2 g]喹啉;thieno [2, 3 g]喹啉;spiro-thieno [2, 3 g]喹啉;苯并[b]噻吩-异喹啉衍生物,因此在现有的综述中,我们对噻吩喹啉的合成进行了全面的更新。根据加成、烷基化、氯化、酰化、氧化、还原、环化和环缩合等反应类型,对制备方法和反应活性进行了表征。因此,本研究将有助于研究人员从上一次文献研究中获得知识,以解决他们在设计新化合物和新工艺时遇到的问题。
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引用次数: 0
Recent Progress for the Synthesis of Pyrrole Derivatives – An Update 吡咯衍生物合成的最新进展
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-05-30 DOI: 10.2174/1570193x20666230530161009
Ashish D. Patel, D. Patel, Drashti Shah, Krishi Patel, Ayush Patel, Tushar Bambharoliya, Anjali Mahavar
Pyrrole is a versatile heterocyclic moiety exhibiting a wide range of pharmacological actions with high therapeutic value. The importance of pyrrole in the pharmaceutical field lies in its versatility, selectivity, and biocompatibility, and these properties make it a valuable tool for drug design and development. The pyrrole moiety is a fundamental building block for many biologically active molecules and has gathered significant attention in the fields of medicinal and organic chemistry; hence, its synthesis has been a crucial area for research. There are various conventional as well as modern approaches to acquiring a series of pyrrole scaffolds, with a wide range of attractive features and drawbacks pertaining to each approach. An extensive amount of literature must be studied to compare the best synthetic routes. This article highlights the applications of pyrrole derivatives in various fields, such as drug discovery, material science, and catalysis, and provides an overview of modern synthetic pathways that include metals, nanomaterials, and complex heterogeneous catalysed methods for pyrrole derivatives. Special emphasis is given to the use of green chemistry principles like green solvent-based methods, microwave-aided methods, and solvent-free methods in the synthesis of pyrroles, with the recent developments and prospects in the synthetic and organic chemistry fields. Overall, this review article provides a comprehensive overview of the synthesis of pyrroles and complies with all the possible developments in the synthetic routes for pyrroles within 2015–2022. Among all, the reactions catalysed by proline, copper oxides, and oxones have been shown to be the most effective synthetic route for pyrrole derivatives at mild reaction conditions and with excellent yields. This information will be helpful for researchers interested in the development of new pyrrole-based compounds. The categorization in this review provides an easy means for the reader to rationally select the best possible synthetic method for pyrrole derivatives.
吡咯是一种多用途的杂环基团,具有广泛的药理作用,具有很高的治疗价值。吡咯在制药领域的重要性在于它的多功能性、选择性和生物相容性,这些特性使它成为药物设计和开发的宝贵工具。吡咯部分是许多生物活性分子的基本组成部分,在药物和有机化学领域引起了极大的关注;因此,其合成一直是一个重要的研究领域。有各种传统的和现代的方法来获得一系列的吡咯支架,具有广泛的吸引人的特点和缺点有关的每一种方法。为了比较最佳的合成路线,必须研究大量的文献。本文重点介绍了吡咯衍生物在药物发现、材料科学和催化等各个领域的应用,并概述了现代合成途径,包括金属、纳米材料和吡咯衍生物的复杂非均相催化方法。重点介绍了绿色溶剂法、微波辅助法和无溶剂法等绿色化学原理在吡咯合成中的应用,并对合成化学和有机化学领域的最新进展和前景进行了展望。总的来说,这篇综述文章提供了吡咯合成的全面概述,并符合2015-2022年吡咯合成路线的所有可能发展。其中,脯氨酸、氧化铜和酮类催化反应是合成吡咯衍生物最有效的途径,反应条件温和,产率高。这些信息将有助于对开发新的吡咯基化合物感兴趣的研究人员。本文的分类为读者合理选择吡咯衍生物的最佳合成方法提供了方便。
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引用次数: 0
1-Cyanoacetylthiosemicarbazides: Recent Advances In Their Synthesis, Reactivity In Heterocyclization, And Bio Applications 1-氰基乙酰基硫代氨基叠氮化物的合成、杂环反应性及其生物应用研究进展
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-05-29 DOI: 10.2174/1570193x20666230529155754
S. Bondock, Nada Alabbad, Aisha Hossana, M. Abdou
The synthesis of 1-cyanoacetylthiosemicarbazides is at the apex attention of researchers due to their multifaced reactivity as versatile precursors in the synthesis of mono-, bi-, and fused_heterocyclic compounds as well as metal complexes. Despite this, no comprehensive survey was, so far, dedicated to the synthesis, chemical transformation, and bioactivities of this relevant family of synthetic organic precursors and their derivatives. The present survey aims to summarize an up-to-date record of the preparation of 1-cyanoacetylthiosemicarbazides and their chemical transformation. A particular focus is given to their metal complexes and bio applications
1-氰乙酰基硫代氨基脲的合成受到了研究人员的高度关注,因为它们具有多面反应性,可以作为合成单、双、融合杂环化合物和金属配合物的多功能前体。尽管如此,到目前为止,还没有对这一相关家族的合成有机前体及其衍生物的合成、化学转化和生物活性进行全面的调查。本文综述了1-氰乙酰基硫代氨基脲的制备及其化学转化的最新研究进展。特别关注的是它们的金属配合物和生物应用
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引用次数: 0
Dichlorophosphoryl Isocyanate: Synthesis, Chemical Reactions, and Biological Activity of its derivatives 异氰酸二氯磷酯:其衍生物的合成、化学反应和生物活性
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-05-26 DOI: 10.2174/1570193x20666230526104159
Nejib Ben Hussein Mekni, F. Medini, L. Aroua
Dichlorophosphoryl isocyanate (DCPI) is the most basic and easy phosphoric isocyanate substrate that introduces organic moieties. Synthesized since 1954, the DCPI has a high reactivity toward primary and secondary alkyl, alcohols, phenols, thiols, and amines via the nucleophilic addition reaction on the carbon atom of the isocyanate group. In addition to their synthesis, the resulting products undergo nucleophilic substitutions of the chlorine atoms. Their reactions with nucleophilic and bi-nucleophile reagents yield acyclic and P-heterocyclic compounds, respectively. The resulting compounds have different potential antibacterial, antifungal, and antitumor activities.
异氰酸二氯磷酯(DCPI)是最基本、最容易引入有机基团的磷酸异氰酸酯底物。自1954年合成以来,DCPI通过在异氰酸酯基团的碳原子上的亲核加成反应,对伯烷基和仲烷基、醇类、酚类、硫醇类和胺类具有很高的反应活性。除了它们的合成外,所得到的产物还经历氯原子的亲核取代。它们与亲核试剂和双亲核试剂反应,分别生成无环和p杂环化合物。所得化合物具有不同的潜在抗菌、抗真菌和抗肿瘤活性。
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引用次数: 0
Chemistry of Thieno [2,3-h]-/[3,2-h] quinoline and Thieno [2,3-f]-/[3,2-f] quinoline derivatives part (x), Reactivities, and Biological Activities 噻吩[2,3-h]-/[3,2-h]喹啉和噻吩[2,3-f]-/[3,2-f]喹啉衍生物的化学性质部分(x)、反应性和生物活性
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-05-25 DOI: 10.2174/1570193x20666230525120540
M. Gouda, Nahlah A. Al-Hadhrami, A. Abu‐Hashem, Ahmed A. M. Abdelgawad, M. A. Salem
Several thieno [2,3-h] /[3,2-h] quinolines and thieno [2,3-f] /[3,2-f] quinolines (TQs) are discussed in this review from a few perspectives, including various preparation and processing methods employing cutting-edge machinery. The preparation of (TQs), from 4-(5)aminobenzothiophene, 2(3)chloromethylthiophene, 2(3)thienylboric acid, and other chemical reagents is illustrated via a number of chemical procedures in this review. The formation of (TQs) was clarified using the Michael addition, Photocyclization, Skraup reaction, Ullmann-Fetvadjian process, Suzuki-Miyaura and Sonogashira reaction, aza-Diels-Alder reaction, and Friedel-Crafts reaction.
本文从几个角度讨论了几种噻吩并[2,3-h]/[3,2-h]喹啉和噻吩并[2,6-f]/[3,2-f]喹啉(TQs),包括采用尖端机械的各种制备和加工方法。本文通过一些化学程序介绍了由4-(5)氨基苯并噻吩、2(3)氯甲基噻吩、2)噻吩基硼酸和其他化学试剂制备(TQs)的方法。使用Michael加成、光循环、Skraup反应、Ullmann Fetvadjian过程、Suzuki Miyaura和Sonogashira反应、aza-Diels-Alder反应和Friedel-Crafts反应澄清了(TQs)的形成。
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引用次数: 0
New Strategies in the Chemical Control of Fusarium Oxysporum using Synthetic Bioisosteres of Secondary Metabolites: A Review of the Synthetic Methods for Novel Compounds with Potential Antifungal Activity 利用次生代谢产物的合成生物同位体化学控制尖孢镰刀菌的新策略:具有潜在抗真菌活性的新化合物的合成方法综述
IF 2.3 4区 化学 Q2 Chemistry Pub Date : 2023-05-16 DOI: 10.2174/1570193x20666230516144539
Diego Quiroga, Paola Borrego-Muñoz, E. Coy-Barrera
One of the main problems affecting the world is food scarcity which is occasioned by different causes, including difficult climatic conditions, economic and technical limitations, infrastructure and transportation, food safety and insecurity, and diseases caused by microorganisms (phytopathogens) such as Fusarium oxysporum whose damage triggers a series of irreversible effects on several crops, causing economic losses worldwide. Given the complexity that the chemical control of phytopathogens represents, various investigations have been refocused on exploring new biomimetic actions that lead to synthesizing new compounds with potential antifungal activity. In addition, computational chemistry and chemoinformatics tools (molecular docking and molecular dynamics) make it possible to understand and often predict these compounds' mechanisms of action, thereby formulating Quantitative Structure-Activity Relationship (QSAR) models. These strategies have established an important advance in designing new molecules capable of inhibiting pathogens from a rational development of antifungal compounds. This article reviewed the novel synthetic bioisosteres of secondary metabolites biologically active against Fusarium oxysporum, their synthetic protocols, and the strategies implemented for its control. The most innovative examples of this class of active organic compounds are presented, such as N,S-dialkyl dithiocarbamates, Schiff bases, N-alkyl substituted amides, and several heterocyclic systems with potential antifungal activity. Likewise, the use of computational tools is discussed, showing how these results can conduce to the design of new antifungal agents.
影响世界的主要问题之一是粮食短缺,这是由不同原因引起的,包括困难的气候条件、经济和技术限制、基础设施和运输、食品安全和不安全,以及由微生物(植物病原体)引起的疾病,如尖孢镰刀菌,其损害对几种作物造成一系列不可逆转的影响,在世界范围内造成经济损失。鉴于植物病原菌化学控制的复杂性,各种研究已经重新聚焦于探索新的仿生作用,从而合成具有潜在抗真菌活性的新化合物。此外,计算化学和化学信息学工具(分子对接和分子动力学)使理解和预测这些化合物的作用机制成为可能,从而形成定量构效关系(QSAR)模型。这些策略从抗真菌化合物的合理发展,在设计能够抑制病原体的新分子方面取得了重要进展。本文综述了对尖孢镰刀菌具有生物活性的次生代谢产物的新型合成生物异构体及其合成方法和防治策略。本文介绍了这类活性有机化合物中最具创新性的例子,如N, s -二烷基二硫代氨基甲酸酯、希夫碱、N-烷基取代酰胺和几种具有潜在抗真菌活性的杂环体系。同样,本文还讨论了计算工具的使用,展示了这些结果如何有助于设计新的抗真菌剂。
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引用次数: 0
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Mini-reviews in Organic Chemistry
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