Pub Date : 2024-01-05DOI: 10.2174/0118756298232086231203163938
Andisiwe Ngwekazi, Christopher Arendse, Priscilla Baker
: Cucurbiturils are a class of macrocyclic compounds with highly polar carbonyl portals and a hydrophobic cavity. They are usually utilized as efficient host molecules in supramolecular chemistry applications due to their high binding affinity for positively charged or cationic compounds. This review investigates the application of CB[n] immobilization at semi-conductive interfaces to produce electrochemical sensors. Critical to the production of thin film electrode preparations is the solubility of the CB[n] to produce homogeneous thin films when deposited. The solubility of CB[n] molecules in organic and inorganic solvents is limited; however, CB[7] has been applied successfully in the production of a wide range of electrochemical sensors. Furthermore, we introduce simple drop-casting of efficiently solubilized CB[7] as a simple yet effective method for producing CB[7] modified electrochemical sensors for the sensitive reporting of dopamine in aqueous solutions in the concentration range of 3.33×10-9 to 1.16×10-8 M with a sensitivity of 0.315 µA/M, (n=3).
{"title":"Functionalization of semi-conductive interfaces with cucurbit[n]urils","authors":"Andisiwe Ngwekazi, Christopher Arendse, Priscilla Baker","doi":"10.2174/0118756298232086231203163938","DOIUrl":"https://doi.org/10.2174/0118756298232086231203163938","url":null,"abstract":": Cucurbiturils are a class of macrocyclic compounds with highly polar carbonyl portals and a hydrophobic cavity. They are usually utilized as efficient host molecules in supramolecular chemistry applications due to their high binding affinity for positively charged or cationic compounds. This review investigates the application of CB[n] immobilization at semi-conductive interfaces to produce electrochemical sensors. Critical to the production of thin film electrode preparations is the solubility of the CB[n] to produce homogeneous thin films when deposited. The solubility of CB[n] molecules in organic and inorganic solvents is limited; however, CB[7] has been applied successfully in the production of a wide range of electrochemical sensors. Furthermore, we introduce simple drop-casting of efficiently solubilized CB[7] as a simple yet effective method for producing CB[7] modified electrochemical sensors for the sensitive reporting of dopamine in aqueous solutions in the concentration range of 3.33×10-9 to 1.16×10-8 M with a sensitivity of 0.315 µA/M, (n=3).","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"25 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139375735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-05DOI: 10.2174/0118756298278048231205053801
Shuo Zhang, Wei Tang, Kai Zhou, Xiao-Xiao Huan, Zhi-Wei Chen
: Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metalcatalyzed or high-temperature cyclization, which is more in line with the advocates of green chemistry. The design of alkenes or alkynes as radical acceptors for cascade reactions presents a novel and robust approach to obtaining coumarin or quinolin-2-one molecules. These radical cascade cyclization reactions have been well explored and studied over the past decade. As a result, we have compiled a review of the rapidly developing cutting-edge research in this field, featuring typical examples and in-depth exploration of the underlying mechanisms.
{"title":"Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions","authors":"Shuo Zhang, Wei Tang, Kai Zhou, Xiao-Xiao Huan, Zhi-Wei Chen","doi":"10.2174/0118756298278048231205053801","DOIUrl":"https://doi.org/10.2174/0118756298278048231205053801","url":null,"abstract":": Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metalcatalyzed or high-temperature cyclization, which is more in line with the advocates of green chemistry. The design of alkenes or alkynes as radical acceptors for cascade reactions presents a novel and robust approach to obtaining coumarin or quinolin-2-one molecules. These radical cascade cyclization reactions have been well explored and studied over the past decade. As a result, we have compiled a review of the rapidly developing cutting-edge research in this field, featuring typical examples and in-depth exploration of the underlying mechanisms.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"25 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139375744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}