Journal of Child Psychology and Psychiatry最新文献

{"title":"Research Review: On the (mis)use of puberty data in the ABCD Study® – a systematic review, problem illustration, and path forward","authors":"Adriene M. Beltz,&nbsp;Holly Pham,&nbsp;Tristin Smith,&nbsp;Esmeralda Hidalgo-Lopez,&nbsp;Hannah Becker,&nbsp;Christel M. Portengen,&nbsp;Mary M. Heitzeg,&nbsp;Chelsea Kaplan,&nbsp;Sheri A. Berenbaum","doi":"10.1111/jcpp.70035","DOIUrl":"10.1111/jcpp.70035","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Adolescent Brain Cognitive Development^SM (ABCD) Study® has significant potential to reveal the nature, causes, context, and consequences of pubertal development in diverse American youth. Optimal use of the data requires thoughtful consideration of puberty: how it is likely to affect psychological and neural development, and its measurement. We examined how ABCD puberty data have been used, and the relative advantages of two measures derived from the Pubertal Development Scale: the categorical measure provided in data releases and a continuous measure widely used outside ABCD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>First, we conducted a review of published studies using ABCD puberty data through December 2024, following PRISMA guidelines. Two independent raters coded the studies for key features. Second, we used data from ABCD baseline and the Year 1 follow-up to empirically compare the categorical and continuous measures in descriptives, reliability, sex differences, twin similarities, and examine correspondence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Systematic review results from 190 reports showed that more studies considered puberty as a covariate (72%) than a variable of interest (28%), with 44% using the categorical measure from data releases and another 28% providing insufficient information to determine measurement. When puberty was a focus, there was variability in the use of youth versus parent-report and approach to missing data, and little attention to sex differences. Results from the empirical comparison showed advantages of the continuous over the categorical measure in data availability, developmental distributions, and reliability; they also confirmed the limited utility of youth-report in early puberty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Results have crucial implications for the use of ABCD puberty data, especially early assessments. They highlight the complexity of studying pubertal influences on adolescent development and emphasize measurement. Attention to these issues will maximize the potential of ABCD to rigorously delineate the role of puberty in brain and behavioral development and to ultimately promote youth well-being.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 1","pages":"138-151"},"PeriodicalIF":7.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1111/jcpp.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a parent advocacy intervention on service access for transition-aged autistic youth: a multisite randomized controlled trial","authors":"Julie Lounds Taylor,&nbsp;Leann Smith DaWalt,&nbsp;Meghan M. Burke,&nbsp;Meng Xu,&nbsp;James C. Slaughter","doi":"10.1111/jcpp.70036","DOIUrl":"10.1111/jcpp.70036","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Autistic youth in the United States face many challenges accessing services as they transition to adulthood. Improving parents' ability to advocate for services is a promising way to improve service access. The current study tested whether participation in an intervention to improve parents' ability to advocate for adult services (called Advocating for Supports to Improve Service Transitions or ASSIST) led to increased service access for their transition-aged autistic youth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using a multisite, single-blind parallel-group design, we randomized 185 parents of transition-aged autistic youth to either a treatment condition that received the ASSIST intervention, or a control condition that received comprehensive written information about adult services. Primary outcomes for this report – number of government programs that fund services and direct services received by the youth – were collected via parental interview at baseline, six, and 12 months after intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Primary analyses found no significant treatment effects on service access. Subgroup analyses, however, detected treatment effects for families of youth who had exited high school prior to their families taking ASSIST. Among those families, youth from the treatment group were receiving more government programs that fund services at 6 months after intervention compared with youth from the control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We cannot conclude from our findings that ASSIST improved access to services, though there was some evidence to suggest increased access to government programs that fund services for families of autistic youth who had exited high school. Future research should investigate which families can translate written information about adult services (i.e. the control condition) into improved service access, and which families need more individualized support beyond a group-based class to see improvements in service access.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 2","pages":"212-224"},"PeriodicalIF":7.0,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12582376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct cascades for secure and insecure infants from early anger dysregulation to mothers' and fathers' power-assertive control at toddler age to externalizing outcomes at preschool age: a replication","authors":"Sanghag Kim,&nbsp;Grazyna Kochanska","doi":"10.1111/jcpp.70034","DOIUrl":"10.1111/jcpp.70034","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bowlby's concept of attachment as a biobehavioral proximity-regulating system providing infants with confidence in protection and support for exploration has been expanded to include early security's legacy for socialization processes. We report a continued programmatic effort to replicate our model of security as a potent catalyst moderating common maladaptive longitudinal cascades from early child difficulty to increased parental power assertion to externalizing developmental outcomes. We elucidate the multifinality of sequelae that can unfold from early child difficulty. Our moderated mediation model proposes that such cascades occur only in parent–child dyads with histories of insecure attachment in infancy; early security buffers those risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Children and Parents Study (CAPS) included 200 community mothers, fathers, and children from the U.S. Midwest. At 16 months (<i>N</i> = 194, 93 girls), we observed children's early difficulty (anger dysregulation) and security with each parent in the Strange Situation Paradigm. At 38 months (age 3, <i>N</i> = 175, 86 girls), we observed parents' power-assertive control. At 52 months (age 4.5, <i>N</i> = 177, 86 girls), we observed children's poor self-regulation and violations of conduct rules and obtained parents' reports of children's disruptive behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For mothers and children, the indirect effects of early anger dysregulation at 16 months on all three outcomes at age 4.5, mediated via increased power assertion at age 3, were present only in insecure dyads, as reflected in significant moderated mediation. Comprehensive analysis that integrated all three outcomes further supported the robust moderating effect of early security for the entire developmental path from anger dysregulation to power assertion to child outcomes, and for each segment of that path. There were no findings for fathers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We discuss the critical importance – and challenges – of replicating models of complex longitudinal cascades when elucidating multifinality throughthe lens unique to developmental psychology and psychopathology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 2","pages":"202-211"},"PeriodicalIF":7.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1111/jcpp.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annual Research Review: Early conduct problems - precursors, outcomes, and etiology.","authors":"Luke W Hyde,Christopher J Trentacosta,Jessica L Bezek","doi":"10.1111/jcpp.70031","DOIUrl":"https://doi.org/10.1111/jcpp.70031","url":null,"abstract":"During the toddler and preschool period, nearly all children engage in some level of aggression, defiance, stealing, and temper tantrums. While the frequency and intensity of these behaviors tends to decrease across early childhood, a subset of children engage in these conduct problem behaviors at a higher intensity early in life and/or do not desist from these behaviors. Instead, these behaviors escalate across childhood and adolescence into serious forms of antisocial behavior (e.g., aggression, rule breaking). Given the negative impacts of these behaviors on children engaging in them, victims, and society, childhood conduct problems are a major public health concern. Here, we provide an updated review of the research identifying the trajectory of conduct problems; risk factors for their emergence, persistence, and escalation; and mechanisms through which risk impacts behavior, using a biopsychosocial and ecological lens. We describe how child and parent attributes contribute to a coercive dyadic cycle that leads to escalating problem behaviors, and how the broader context undermines these proximal relationships to increase risk for conduct problems. Next, we consider the role that genetics plays in these processes and describe how gene-environment interplay shapes early conduct problems. Further, we describe the ways in which these environmental and genetic risk processes impact brain development to increase risk for conduct problems. Finally, we discuss recent approaches to prevent and treat conduct problems and discuss research needs to better support our understanding of the development, prevention, and treatment of early conduct problems.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"48 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early manifestations of unexpected bilingualism in minimally verbal autism.","authors":"David Gagnon,Alexia Ostrolenk,Laurent Mottron","doi":"10.1111/jcpp.70032","DOIUrl":"https://doi.org/10.1111/jcpp.70032","url":null,"abstract":"BACKGROUNDUnexpected bilingualism (UB) in autism, in which children speak languages not spoken in their social environment, has been sporadically reported. UB implies that autistic children can acquire languages in a non-socially interactive way. The early minimally verbal period in autism could be critical for non-interactive language acquisition, given the predominance of non-social interests at that time. However, evidence of language acquisition outside social interaction during this period remains limited and restricted to small case studies.METHODSCaregivers of 119 autistic, 102 non-autistic clinical, and 75 typically developing (TD) children aged 2-6 years completed a structured questionnaire about their children's language-related interests and use. They were also asked to estimate the relative proportion of each language their children were exposed to in their social environment. UB was operationalized as the use of at least one language not spoken in the child's social environment to name letters and/or numbers.RESULTSOf the autistic group, 53% were considered minimally verbal. A total of 38.7% of autistic children displayed UB, with autistic children being 4.38 times more likely to show UB than TD children (p < .001). In contrast, the non-autistic clinical children did not differ significantly from TD children. The presence of UB was not associated with the children's expressive language level. Autistic children were 8.28 times more likely than TD children to use a non-dominant language (here English) (p < .001), after controlling for their proportion of social exposure to that language. Non-interactive media were the only sources caregivers reported to explain the presence of UB in autistic children.CONCLUSIONSAutistic children, even those who are minimally verbal, are less dependent on their social environment for specific aspects of language development. Non-interactive pathways of language acquisition may have a prominent role in early language development in autism.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"23 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory hyperacusis as a predictor of anxiety in adolescence.","authors":"Foteini Tseliou,Stephan Collishaw,Alice Price,Petroc Sumner","doi":"10.1111/jcpp.70027","DOIUrl":"https://doi.org/10.1111/jcpp.70027","url":null,"abstract":"BACKGROUNDAn increasing number of children report anxiety in early to mid-adolescence. Early identification of risk during the transition from primary to secondary schools (age 11) could enhance family- or school-based interventions. While known predictors of adolescent anxiety provide some insight, there is a need to identify and understand additional risk factors. Hyperacusis (aversive sensitivity to sound) is correlated with anxiety in children and adults and thus a candidate risk factor longitudinally.METHODSWe explored the predictive potential of auditory hyperacusis using data from the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 6,621). Hyperacusis at age 11 was assessed with a single question, while anxiety and related emotional problems were captured by the emotional subscale of the Strength and Difficulties Questionnaire (SDQ-E) at ages 13, 16 and through longitudinal trajectories (4-16 years).RESULTSHyperacusis significantly predicted anxiety at ages 13 and 16. This predictive effect remained for age 13 even when accounting for pre-existing anxiety/emotional problems, autism traits and other neurodiversity characteristics (ADHD, dyslexia, dyspraxia). Similar, though less pronounced, patterns emerged at age 16. When testing the four previously identified childhood trajectories of emotional problems, hyperacusis predicted persistent versus decreasing trajectories (the two cases when preschool anxiety is already high) more reliably than increasing from low trajectories (the two cases when preschool anxiety is low). Additional exploratory analyses found that hyperacusis was most strongly associated with SDQ-E items related to fear, worry, and nervousness; still predicted SDQ-E scores at age 25, but not adult generalised anxiety disorder, major depressive disorder or suicidal self-harm.CONCLUSIONSTaken together, our findings suggest that assessing hyperacusis at age 11 can provide additional predictive insights into the exacerbation and maintenance of anxiety in adolescence.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"6 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal expressions of warmth and negativity and adolescent mental health: using longitudinal monozygotic twin-difference analyses to approach causal inference","authors":"Alice Wickersham,&nbsp;Avshalom Caspi,&nbsp;Louise Arseneault,&nbsp;Terrie E. Moffitt,&nbsp;Johnny Downs,&nbsp;Antony Ambler,&nbsp;Rachel M. Latham,&nbsp;Nicholas Cummins,&nbsp;Zoë Firth,&nbsp;Jasmin Wertz,&nbsp;Helen L. Fisher","doi":"10.1111/jcpp.70020","DOIUrl":"10.1111/jcpp.70020","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Emotions that mothers express about their offspring are associated with offspring mental health during childhood, but little research has explored whether this extends into adolescence. We investigated associations between maternal warmth and negativity towards twin offspring at age 10, and subsequent mental health outcomes in early and late adolescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Environmental Risk (E-Risk) Longitudinal Twin Study is a population-based cohort of 2,232 same-sex twins born in 1994–1995 across England and Wales. Maternal warmth and negativity were assessed from Five-Minute Speech Samples obtained when twins were aged 10. Continuous mental health outcomes were assessed in interviews with twins at ages 12 (depression, anxiety, attention-deficit hyperactivity disorder and conduct disorder) and 18 (general psychopathology, internalising, externalising and thought disorder). Linear regressions were conducted on 1906 participants with available data and adjusted for sex, family socioeconomic status, and age-5 emotional and behavioural problems. We then conducted a monozygotic twin-difference analysis to control for unmeasured shared environmental and genetic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Lower maternal warmth and higher maternal negativity were associated with worse mental health outcomes at ages 12 and 18. For example, when comparing differences in mothers' expressed emotions and mental health outcomes within monozygotic twin pairs, higher negativity remained associated with externalising symptoms (<i>b</i> = 1.77, 95% CI = 0.68 to 2.86, <i>β</i> = .14) and poorer general psychopathology (<i>b</i> = 1.82, 95% CI = 0.63 to 3.01, <i>β</i> = .13), and lower warmth with externalising symptoms (<i>b</i> = −1.96, 95% CI = −3.54 to −0.37, <i>β</i> = −.11). These associations remained after adjusting for twin-differences in age-5 emotional and behavioural problems and birth weight. Null findings were more frequently observed for maternal warmth and internalising outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Using a genetically sensitive design to approach causal inference, we found evidence for associations between maternal warmth/negativity and adolescent mental health outcomes. Maternal expressed emotion ratings might provide an early opportunity to identify families who would benefit from interventions and mental health disorder prevention programmes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 1","pages":"92-103"},"PeriodicalIF":7.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1111/jcpp.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of comorbid childhood mental health and neurodevelopmental conditions in the persistence of ADHD symptoms: systematic review and meta-analysis","authors":"Yuan You,&nbsp;Tom McAdams,&nbsp;Yasmin I. Ahmadzadeh,&nbsp;Tabea Schoeler,&nbsp;Filip Marzecki,&nbsp;Helena M.S. Zavos","doi":"10.1111/jcpp.70028","DOIUrl":"10.1111/jcpp.70028","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Children diagnosed with ADHD and other comorbid mental health conditions often exhibit more severe functional impairments than those without comorbid conditions, including a tendency for their ADHD symptoms to persist into later developmental stages. We conducted a systematic review and quantitative analysis to investigate the extent to which specific childhood comorbidities (internalizing, externalizing and neurodevelopmental conditions) predict the persistence of childhood ADHD into later developmental stages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We extracted data from 26 studies meeting the criteria for inclusion and applied multilevel random effects models to obtain pooled estimates of Cohen's <i>d</i> for selected predictors on ADHD persistence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Childhood comorbid internalizing and externalizing conditions (<i>d</i> = 0.19 and <i>d</i> = 0.31, respectively), but not neurodevelopmental disorders, were significantly associated with ADHD persistence. After adjusting for covariates (sex, age and other comorbidities), this association diminished for externalizing conditions (<i>d</i>_adj = 0.24) and was no longer significant for internalizing conditions (<i>d</i>_adj = 0.06). The association between comorbid externalizing behavior problems and ADHD persistence was found only in studies that used parent-reported data to measure childhood ADHD and externalizing conditions, but not in studies that included teacher-reported childhood symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Childhood comorbid externalizing and, to a lesser extent, internalizing conditions were associated with the persistence of ADHD, but this association may be partially due to confounders. Childhood comorbidity of neurodevelopmental disorders does not appear to increase the likelihood of ADHD persistence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 2","pages":"183-201"},"PeriodicalIF":7.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1111/jcpp.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging biomarkers in school-aged children with autism: MRI-measured lipid content in the limbic system.","authors":"Ya-Yin Deng,Xiang Zhou,Bo-Ya Yin,Feng-Yun Zou,Shuang-Shuang Zhong,Xiao-Wen Luo,Li-Shan Shen,Yang Fan,Ruo-Mi Guo","doi":"10.1111/jcpp.70033","DOIUrl":"https://doi.org/10.1111/jcpp.70033","url":null,"abstract":"BACKGROUNDAutism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Alterations in brain lipids may elucidate ASD's neurophysiological mechanisms, but evidence remains limited. This study aims to assess whether the MRI-measured lipid content in limbic brain regions could serve as novel biomarkers for neurophysiological changes in school-aged children with ASD.METHODSThis prospective study included 98 school-aged (7-16 years) children with ASD and 94 age- and gender-matched typically developing (TD) children, an age window selected based on established milestones of structural brain maturation. Lipid content in limbic regions was quantified via MRI-based proton density fat fraction (PDFF). Between-group differences, blood lipid correlations, and clinical scale associations were analyzed. In vitro validation and histopathology in ASD mice confirmed lipid quantification accuracy and deposits. Receiver operating characteristic (ROC) analyses evaluated diagnostic utility.RESULTSChildren with ASD exhibited significantly elevated MRI-measured lipid content in the bilateral fusiform gyrus (FUS) (pfdr < .01), with positive correlations observed between lipid content and total cholesterol (left hemisphere: r = .38, p < .01; right hemisphere r = .46, p < .01). Histopathological examination of BTBR mice brain sections stained with ammonium ferric sulfate revealed significant cholesterol deposits. Additionally, reduced lipid content in the bilateral caudal anterior cingulate cortex (cACC) (left hemisphere: pfdr < .01, right hemisphere: pfdr < .01) was found in children with ASD, and the lipid content of the right cACC was negatively correlated with impairments in social communication (r = -.32, pfdr = .04). Results of ROC analyses demonstrated that multimodal integration of bilateral FUS and cACC lipid contents yielded the highest AUC (0.89, 95% CI: 0.84-0.94).CONCLUSIONSAlterations in the FUS and cACC underscore their roles in ASD neuropathology. These findings suggest that MRI-measured lipid levels of specific regions from the brain limbic system could serve as a biomarker for neurophysiological changes in school-aged children with ASD.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"113 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intergenerational transmission of maternal childhood maltreatment, prenatal substance exposure, and internalizing and externalizing symptoms in early adolescence at age 12","authors":"Meeyoung O. Min,&nbsp;June-Yung Kim,&nbsp;Sonia Minnes,&nbsp;Rosa Kim,&nbsp;Lynn T. Singer","doi":"10.1111/jcpp.70030","DOIUrl":"10.1111/jcpp.70030","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Few studies have examined the intergenerational impact of maternal childhood maltreatment (MCM) in the context of prenatal substance exposure (PSE). This study investigates whether PSE is part of the pathway of MCM or an independent risk factor affecting offspring psychopathology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants were 284 birth mother–child (44% male) dyads, primarily Black, low-income, enrolled at birth. Exposure to alcohol, tobacco, marijuana, or cocaine in utero was assessed at 1 month postpartum. MCM was assessed at child age 4, and maternal psychological distress and offspring maltreatment at child age 10. Mother- and child-reported internalizing and externalizing symptoms were assessed at child age 12 using the Child Behavior Checklist and the Youth Self-Report. Structural equation modeling was conducted to test sequential mediation pathways examining the direct and indirect associations of MCM with child internalizing and externalizing symptoms via PSE, maternal psychological distress, and offspring maltreatment, adjusting for covariates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MCM was directly related to adolescent-reported internalizing and externalizing symptoms, whereas PSE was directly related to adolescent-reported externalizing symptoms. MCM and PSE were indirectly related to mother-reported internalizing and externalizing symptoms via maternal psychological distress. Only PSE was related to offspring maltreatment at 10 years, and offspring maltreatment was related to both mother- and adolescent-reported internalizing and externalizing symptoms at 12 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MCM and PSE may increase offspring vulnerability to psychopathology, highlighting the importance of evaluating historical risks that mothers may transmit from their own childhood maltreatment and prenatal substance use in assessing offspring psychopathology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 2","pages":"171-182"},"PeriodicalIF":7.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1111/jcpp.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}