To discover biorational natural product-based pesticides, a series of paeonol ester derivatives containing a Schiff base (6a-j, 7i,j, 8i,j, and 9i,j) were prepared, and their structures were well characterised by 1H NMR and HRMS. Furthermore, bioactivities of these compounds as anti-oomycete and anti-fungal agents against two serious agricultural diseases, Phytophthora capsici and Fusarium graminearum we assessed. Amongst evaluated compounds, 1) Compounds 6a and 6e displayed good anti-oomycete against P. capsici, with EC50 values of 116.50 and 88.86 mg/L, respectively. 2) Compounds 6e and 7i exhibited prominent anti-fungal against F. graminearum, with EC50 values of 66.73 and 29.33 mg/L, respectively. 3) This study suggested that the introduction of nitro at the C5 position of paeonol could improve its bioactivity against P. capsici and F. graminearum. The results of this study pave the way for further design and development of paeonol derivatives as plant anti-oomycetes and anti-fungal agents in crop protection.
{"title":"Synthesis, anti-oomycete and anti-fungal activities of novel paeonol ester derivatives containing a schiff base","authors":"Xiaofang Zhang , Xiaolong Guo , Wanying Yin , Ruiguang Wang , Yuee Tian , Huilu Sun , Shaobin Xu , Shaoyan Shuang , Xiaobo Huang , Genqiang Chen , Zhiping Che","doi":"10.1080/14786419.2024.2426205","DOIUrl":"10.1080/14786419.2024.2426205","url":null,"abstract":"<div><div>To discover biorational natural product-based pesticides, a series of paeonol ester derivatives containing a Schiff base (<strong>6a-j</strong>, <strong>7i,j</strong>, <strong>8i,j</strong>, and <strong>9i,j</strong>) were prepared, and their structures were well characterised by <sup>1</sup>H NMR and HRMS. Furthermore, bioactivities of these compounds as anti-oomycete and anti-fungal agents against two serious agricultural diseases, <em>Phytophthora capsici</em> and <em>Fusarium graminearum</em> we assessed. Amongst evaluated compounds, 1) Compounds <strong>6a</strong> and <strong>6e</strong> displayed good anti-oomycete against <em>P. capsici</em>, with EC<sub>50</sub> values of 116.50 and 88.86 mg/L, respectively. 2) Compounds <strong>6e</strong> and <strong>7i</strong> exhibited prominent anti-fungal against <em>F. graminearum</em>, with EC<sub>50</sub> values of 66.73 and 29.33 mg/L, respectively. 3) This study suggested that the introduction of nitro at the C5 position of paeonol could improve its bioactivity against <em>P. capsici</em> and <em>F. graminearum</em>. The results of this study pave the way for further design and development of paeonol derivatives as plant anti-oomycetes and anti-fungal agents in crop protection.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 839-848"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phytochemical investigation of the rhizomes and the leaves of Curculigo orchioides led to the isolation of fourteen compounds. They consist of one undescribed dihydrobenzofuran, curcorchidihydrobenzofuran A (1), two undescribed benzyl benzoate glycosides, curculigoside J (2) and K (3), and eleven known compounds (4–14). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data. Compound 1 displayed significant anti-proliferative activities against cervical cancer cells (HelaS3, IC50 = 3.6 µM) and breast cancer cells (MCF-7, IC50 = 13.9 µM) while showing moderate activities against lung cancer cells (A549, IC50 = 29.8 µM). Importantly, it was non-toxic to Vero cells. Compound 1 also inhibited the tyrosinase enzyme in a moderate manner (IC50 = 120.8 µM). Eventually, its permethylated synthetic analog 1a showed a significant suppression of lipopolysaccharide (LPS)-induced NO production in murine macrophage RAW 264.7 (IC50 = 23.4 µM).
{"title":"Curculigosides J–K and curcorchidihydrobenzofuran A, a dihydrobenzofuran with anti-proliferative properties from Curculigo orchioides","authors":"Phornnapa Saentao , Florian T. Schevenels , Jantana Yahuafai , Anupong Joompang , Thanapat Suebrasri , Sophon Boonlue , Sarawut Tontapha , Ratsami Lekphrom","doi":"10.1080/14786419.2024.2426064","DOIUrl":"10.1080/14786419.2024.2426064","url":null,"abstract":"<div><div>Phytochemical investigation of the rhizomes and the leaves of <em>Curculigo orchioides</em> led to the isolation of fourteen compounds. They consist of one undescribed dihydrobenzofuran, curcorchidihydrobenzofuran A (<strong>1</strong>), two undescribed benzyl benzoate glycosides, curculigoside J (<strong>2</strong>) and K (<strong>3</strong>), and eleven known compounds (<strong>4</strong>–<strong>14</strong>). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data. Compound <strong>1</strong> displayed significant anti-proliferative activities against cervical cancer cells (HelaS3, IC<sub>50</sub> = 3.6 µM) and breast cancer cells (MCF-7, IC<sub>50</sub> = 13.9 µM) while showing moderate activities against lung cancer cells (A549, IC<sub>50</sub> = 29.8 µM). Importantly, it was non-toxic to <em>Vero</em> cells. Compound <strong>1</strong> also inhibited the tyrosinase enzyme in a moderate manner (IC<sub>50</sub> = 120.8 µM). Eventually, its permethylated synthetic analog <strong>1a</strong> showed a significant suppression of lipopolysaccharide (LPS)-induced NO production in murine macrophage RAW 264.7 (IC<sub>50</sub> = 23.4 µM).</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 813-825"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2429110
Zhen-Yu Wang , Chun-Hui Wu , Xiao-Han Ren , Wei Zhang , Shao-Yong Zhang , Huan Qi , Jun Huang , Ji-Dong Wang , Hui Zhang
The purpose of this work was to investigate the crystal structure and degradant products (DPs) of tenvermectin B (TVM B). A suitable crystal of TVM B was obtained from a solvent system (MeOH:formamide:H2O = 2:5:2) and its absolute configuration was unambiguously established by single-crystal X-ray diffraction analysis. Meanwhile, a formamide-assisted crystallisation method for the purification of TVM B was developed. During the stress degradation studies of TVM B, four DPs (DPs 1-4) were prepared and characterised by MS and NMR. Among them, DP 2 and DP 3 have not been reported previously. In addition, the nematocidal activity of these DPs were evaluated.
这项工作的目的是研究十维菌素B（TVM B）的晶体结构和降解产物（DPs）。在溶剂体系（MeOH:甲酰胺:H2O=2:5:2）中获得了合适的 TVM B 晶体，并通过单晶 X 射线衍射分析明确了其绝对构型。同时，还开发了一种甲酰胺辅助结晶方法来纯化 TVM B。在 TVM B 的应力降解研究中，制备了四种 DPs（DPs 1-4），并通过 MS 和 NMR 对其进行了表征。其中，DP 2 和 DP 3 以前从未报道过。此外，还对这些 DPs 的杀线虫活性进行了评估。
{"title":"Crystal structure and the degradation products of Tenvermectin B","authors":"Zhen-Yu Wang , Chun-Hui Wu , Xiao-Han Ren , Wei Zhang , Shao-Yong Zhang , Huan Qi , Jun Huang , Ji-Dong Wang , Hui Zhang","doi":"10.1080/14786419.2024.2429110","DOIUrl":"10.1080/14786419.2024.2429110","url":null,"abstract":"<div><div>The purpose of this work was to investigate the crystal structure and degradant products (DPs) of tenvermectin B (TVM B). A suitable crystal of TVM B was obtained from a solvent system (MeOH:formamide:H<sub>2</sub>O = 2:5:2) and its absolute configuration was unambiguously established by single-crystal X-ray diffraction analysis. Meanwhile, a formamide-assisted crystallisation method for the purification of TVM B was developed. During the stress degradation studies of TVM B, four DPs (DPs <strong>1</strong>-<strong>4</strong>) were prepared and characterised by MS and NMR. Among them, DP <strong>2</strong> and DP <strong>3</strong> have not been reported previously. In addition, the nematocidal activity of these DPs were evaluated.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 874-880"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2429112
Wenqing Liu , Sha Yang , Yongchun Pan , Bingliang Wei , Mingsong Liu , Huajie Zhu , Zhidong Xu
Curcumin, originally isolated as natural product from the rhizome of Curcuma longa L., is widely known for its anticancer properties. However, the clinical application of curcumin is still limited due to its poor absorption and rapid metabolism. In this study, structural modification of curcumin by introducing active small organic acids into its pyrazole ring intermediate, was employed to yield five curcumin derivatives 5a-5e. All the target compounds were characterised by 1H NMR,13C NMR and ESI-MS. Biological evaluation through the CCK-8 method indicated that nearly all these derivatives displayed higher proliferation inhibitory effect on A549 cells than that of curcumin. Among them, 5d bearing biotin moiety exhibited even stronger cytotoxicity action (2.25 μmol/L) than the positive control drug Doxorubicin (3.99 μmol/L) and therefore became the most promising lead compound for further investigation. Our findings provided a potential approach for the structural optimisation of curcumin derivatization in cancer treatment.
{"title":"Novel curcumin derivatives as potential anticancer agents: design, synthesis and biological evaluation","authors":"Wenqing Liu , Sha Yang , Yongchun Pan , Bingliang Wei , Mingsong Liu , Huajie Zhu , Zhidong Xu","doi":"10.1080/14786419.2024.2429112","DOIUrl":"10.1080/14786419.2024.2429112","url":null,"abstract":"<div><div>Curcumin, originally isolated as natural product from the rhizome of <em>Curcuma longa</em> L., is widely known for its anticancer properties. However, the clinical application of curcumin is still limited due to its poor absorption and rapid metabolism. In this study, structural modification of curcumin by introducing active small organic acids into its pyrazole ring intermediate, was employed to yield five curcumin derivatives <strong>5a-5e</strong>. All the target compounds were characterised by <sup>1</sup>H NMR,<sup>13</sup>C NMR and ESI-MS. Biological evaluation through the CCK-8 method indicated that nearly all these derivatives displayed higher proliferation inhibitory effect on A549 cells than that of curcumin. Among them, <strong>5d</strong> bearing biotin moiety exhibited even stronger cytotoxicity action (2.25 μmol/L) than the positive control drug Doxorubicin (3.99 μmol/L) and therefore became the most promising lead compound for further investigation. Our findings provided a potential approach for the structural optimisation of curcumin derivatization in cancer treatment.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 881-890"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2025.2480669
Layse Kristine Corrêa Lopes , Eloisa Helena de Aguiar Andrade , Mozaniel Santana de Oliveira , Diego Demarco , José Floriano Barêa Pastore , Ana Cristina Andrade de Aguiar Dias
This study presents a comprehensive chemical analysis of the essential oil isolated from Senega longicaulis, and aroma analysis of Senega adenophora and Senega appressa, employing both fresh and dried samples. Notable differences were observed between the fresh and dried samples of essential oil from S. longicaulis. In the fresh sample, the predominant compounds were (E,E)-geranyl linalool (33.21%) and dendrolasin (19.64%), whereas in the dried sample, (E,E)-geranyl linalool increased to 39.19% and dendrolasin to 18.83%. The oxygenated sesquiterpenes were found to be more abundant in the dried sample (81.52%) than in the fresh sample (69.96%). In the case of S. adenophora and S. appressa, the aroma analysis indicated that β-elemene (49.05%) and methyl salicylate (31.13%), respectively, were the primary compounds present in the fresh samples. These findings illustrate how the drying process has the effect of intensifying certain chemical components in the samples of S. longicaulis.
{"title":"First report on the chemical composition of volatile compounds in the essential oils and aromas of Senega adenophora, Senega appressa, and Senega longicaulis (Polygalaceae)","authors":"Layse Kristine Corrêa Lopes , Eloisa Helena de Aguiar Andrade , Mozaniel Santana de Oliveira , Diego Demarco , José Floriano Barêa Pastore , Ana Cristina Andrade de Aguiar Dias","doi":"10.1080/14786419.2025.2480669","DOIUrl":"10.1080/14786419.2025.2480669","url":null,"abstract":"<div><div>This study presents a comprehensive chemical analysis of the essential oil isolated from <em>Senega longicaulis</em>, and aroma analysis of <em>Senega adenophora</em> and <em>Senega appressa</em>, employing both fresh and dried samples. Notable differences were observed between the fresh and dried samples of essential oil from <em>S. longicaulis</em>. In the fresh sample, the predominant compounds were (<em>E</em>,<em>E</em>)-geranyl linalool (33.21%) and dendrolasin (19.64%), whereas in the dried sample, (<em>E</em>,<em>E</em>)-geranyl linalool increased to 39.19% and dendrolasin to 18.83%. The oxygenated sesquiterpenes were found to be more abundant in the dried sample (81.52%) than in the fresh sample (69.96%). In the case of <em>S. adenophora</em> and <em>S. appressa</em>, the aroma analysis indicated that <em>β</em>-elemene (49.05%) and methyl salicylate (31.13%), respectively, were the primary compounds present in the fresh samples. These findings illustrate how the drying process has the effect of intensifying certain chemical components in the samples of <em>S. longicaulis</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 931-936"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2426072
G. Fru Chi , Serab Khan , Jenifer R. N. Kuete , Valaire Y. Matieta , Japheth. O. Ombito , Alfred. N. Tamfu , Junior F. Megaptche , Melvis A. Chongong , Taye B. Demissie , Victor Kuete , Farzana Shaheen
Tetrapleura tetraptera fruit, used as spice in West Africa was studied chemically; five previously undescribed triterpenoid saponins 1–5 and four known compounds 6–9 were isolated from the n-Butanol fraction. The chemical structures of all nine isolates were determined by comprehensive analysis of HRMS, 1D & 2D NMR experiments and by comparison with data in the literature. All nine compounds were evaluated for antibacterial activity by the broth microdilution through the rapid p-iodonitrotetrazolium chloride (INT) colorimetric technique. The results showed that only compounds 5 (MIC = 64 µg/mL against P. aeruginosa and P. stuartii) and 8 (MIC = 64 µg/mL against E. coli) exhibited moderate antibacterial activity. The rest of the compounds displayed weak antibacterial activity against the tested organisms. Molecular docking studies was used to comprehend antibacterial activities.
{"title":"Triterpenoid saponins from the fruit pulp of Tetrapleura tetraptera (Fabaceae)","authors":"G. Fru Chi , Serab Khan , Jenifer R. N. Kuete , Valaire Y. Matieta , Japheth. O. Ombito , Alfred. N. Tamfu , Junior F. Megaptche , Melvis A. Chongong , Taye B. Demissie , Victor Kuete , Farzana Shaheen","doi":"10.1080/14786419.2024.2426072","DOIUrl":"10.1080/14786419.2024.2426072","url":null,"abstract":"<div><div><em>Tetrapleura tetraptera</em> fruit, used as spice in West Africa was studied chemically; five previously undescribed triterpenoid saponins <strong>1</strong>–<strong>5</strong> and four known compounds <strong>6</strong>–<strong>9</strong> were isolated from the <em>n</em>-Butanol fraction. The chemical structures of all nine isolates were determined by comprehensive analysis of HRMS, 1D & 2D NMR experiments and by comparison with data in the literature. All nine compounds were evaluated for antibacterial activity by the broth microdilution through the rapid <em>p</em>-iodonitrotetrazolium chloride (INT) colorimetric technique. The results showed that only compounds <strong>5</strong> (MIC = 64 µg/mL against <em>P. aeruginosa</em> and <em>P. stuartii</em>) and <strong>8</strong> (MIC = 64 µg/mL against <em>E. coli</em>) exhibited moderate antibacterial activity. The rest of the compounds displayed weak antibacterial activity against the tested organisms. Molecular docking studies was used to comprehend antibacterial activities.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 826-838"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1080/14786419.2024.2425793
Zeeshan Akbar , Malik Shoaib Ahmad
Serine proteases are involved in various ailments, including pancreatitis, and colon cancer. Based on substrate recognition serine proteases are classified into different groups. Trypsin and trypsin-like serine proteases are among most studied group of serine proteases. Trypsin is among the chief hydrolysing enzyme involved in the pathogenesis of pancreatitis. Its inhibition can help to manage the disease. Herein, we investigated the trypsin inhibitory effect of some arginine-based small molecules, through in vitro, in silico, and crystallographic methods. Compounds 1-3 were evaluated against bovine pancreatic trypsin (BPT). Compound 1 was found to be active against trypsin with IC50 value of 247.98 ± 2.44 μM. Molecular docking studies were used to investigate the binding energy and binding conformation of inhibitor. All three compounds were subjected to crystallisation with trypsin. Compounds 1-2 were successfully crystallised with BPT The crystal structures of trypsin in complexed with compounds 1, and 2 were determined at 2.30 and 2.50 Å resolution, respectively. Both molecules showed their binding affinity with the active site residues of trypsin. This study will provide insight into the binding mechanism of E-64 and arginine and might be useful in designing effective inhibitors of serine proteases.
{"title":"In vitro, in silico and crystallographic-based identification of serine protease inhibitors","authors":"Zeeshan Akbar , Malik Shoaib Ahmad","doi":"10.1080/14786419.2024.2425793","DOIUrl":"10.1080/14786419.2024.2425793","url":null,"abstract":"<div><div>Serine proteases are involved in various ailments, including pancreatitis, and colon cancer. Based on substrate recognition serine proteases are classified into different groups. Trypsin and trypsin-like serine proteases are among most studied group of serine proteases. Trypsin is among the chief hydrolysing enzyme involved in the pathogenesis of pancreatitis. Its inhibition can help to manage the disease. Herein, we investigated the trypsin inhibitory effect of some arginine-based small molecules, through <em>in vitro</em>, <em>in silico</em>, and crystallographic methods. Compounds <strong>1</strong>-<strong>3</strong> were evaluated against bovine pancreatic trypsin (BPT). Compound <strong>1</strong> was found to be active against trypsin with IC<sub>50</sub> value of 247.98 ± 2.44 <em>μ</em>M. Molecular docking studies were used to investigate the binding energy and binding conformation of inhibitor. All three compounds were subjected to crystallisation with trypsin. Compounds <strong>1</strong>-<strong>2</strong> were successfully crystallised with BPT The crystal structures of trypsin in complexed with compounds <strong>1</strong>, and <strong>2</strong> were determined at 2.30 and 2.50 Å resolution, respectively. Both molecules showed their binding affinity with the active site residues of trypsin. This study will provide insight into the binding mechanism of E-64 and arginine and might be useful in designing effective inhibitors of serine proteases.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 753-759"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study represents the first investigation of the volatile composition of Calystegia silvatica (Convolvulaceae) collected in Algeria, using headspace solid-phase microextraction and gas chromatography/mass spectrometry (HS-SPME-GC/MS). This technique allowed the identification of 44 compounds, constituting 96.9% of the total components. These compounds belong to various chemical classes, including sesquiterpene hydrocarbons (22) and non-terpene derivatives (13), as major groups. Remarkably, the volatile profile of C. silvatica was dominated by sesquiterpenoids (87.1%), particularly sesquiterpene hydrocarbons (83%). Analysis of the aroma profile revealed that the main metabolites were β-caryophyllene, α-gurjunene and germacrene D. Oxygenated sesquiterpenes were present in a smaller proportion (4.1%), mostly represented by palustrol. Other chemical classes, such as monoterpene hydrocarbons, oxygenated monoterpenes, non-terpene derivatives and apocarotenes, have been found in limited quantities. It is worth noting that the data presented in this study have not previously been reported for Calystegia species.
{"title":"Headspace solid phase microextraction combined with GC–MS for the analysis of volatile compounds of Calystegia silvatica (Kit.) Griseb. from Algeria","authors":"Amina Boudjada , Amirat Mokhtar , Hamdi Bendif , Rebbas Khellaf , Guido Flamini , STefania Garzoli","doi":"10.1080/14786419.2025.2478297","DOIUrl":"10.1080/14786419.2025.2478297","url":null,"abstract":"<div><div>This study represents the first investigation of the volatile composition of <em>Calystegia silvatica</em> (Convolvulaceae) collected in Algeria, using headspace solid-phase microextraction and gas chromatography/mass spectrometry (HS-SPME-GC/MS). This technique allowed the identification of 44 compounds, constituting 96.9% of the total components. These compounds belong to various chemical classes, including sesquiterpene hydrocarbons (22) and non-terpene derivatives (13), as major groups. Remarkably, the volatile profile of <em>C. silvatica</em> was dominated by sesquiterpenoids (87.1%), particularly sesquiterpene hydrocarbons (83%). Analysis of the aroma profile revealed that the main metabolites were <em>β</em>-caryophyllene, <em>α</em>-gurjunene and germacrene D. Oxygenated sesquiterpenes were present in a smaller proportion (4.1%), mostly represented by palustrol. Other chemical classes, such as monoterpene hydrocarbons, oxygenated monoterpenes, non-terpene derivatives and apocarotenes, have been found in limited quantities. It is worth noting that the data presented in this study have not previously been reported for <em>Calystegia</em> species.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 3","pages":"Pages 915-923"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1080/14786419.2026.2613344
Husni Farah, Waleed K Abdulsahib, Ihsan Khudhair Jasim, Soumya V Menon, Pradeepta Sekhar Patro, A Sabarivani, Gunjan Mukherjee, Aashna Sinha, Jasur Rizaev
Wogonin, a flavonoid derived from the plant Scutellaria baicalinase's, has emerged as a promising candidate for sepsis management due to its multifaceted pharmacological properties. A comprehensive search of databases, including Google Scholar, Scopus, Web of Science, PubMed, and Embase, was conducted up to November 2025 using relevant keywords. In-vivo studies were assessed using the SYRCLE risk of bias tool, and in-vitro studies were evaluated with the OHAT risk of bias tool. A total of 449 articles were initially sourced, ultimately, 24 publications included in this systematic review. Evidence from various in-vivo and in-vitro studies indicates that wogonin exerts protective effects against sepsis-induced organ damage by modulating critical signalling pathways such as NF-κB, MAPK, and Nrf2/HO-1. Despite these promising findings, further clinical trials are necessary to establish the safety and efficacy of wogonin in human subjects suffering from sepsis.
黄芩苷是一种从黄芩苷中提取的黄酮类化合物，由于其多方面的药理特性，已成为脓毒症治疗的有希望的候选药物。我们使用相关关键词对谷歌Scholar、Scopus、Web of Science、PubMed和Embase等数据库进行了全面检索，检索时间截止到2025年11月。使用sycle偏倚风险工具评估体内研究，使用OHAT偏倚风险工具评估体外研究。总共有449篇文章最初被引用，最终有24篇出版物被纳入本系统综述。来自各种体内和体外研究的证据表明，wogonin通过调节NF-κB、MAPK和Nrf2/HO-1等关键信号通路，对败血症诱导的器官损伤具有保护作用。尽管有这些令人鼓舞的发现，但需要进一步的临床试验来确定沃戈宁对人类败血症患者的安全性和有效性。
{"title":"Therapeutic effects of wogonin on sepsis and its mechanisms of action: a comprehensive systematic review.","authors":"Husni Farah, Waleed K Abdulsahib, Ihsan Khudhair Jasim, Soumya V Menon, Pradeepta Sekhar Patro, A Sabarivani, Gunjan Mukherjee, Aashna Sinha, Jasur Rizaev","doi":"10.1080/14786419.2026.2613344","DOIUrl":"https://doi.org/10.1080/14786419.2026.2613344","url":null,"abstract":"<p><p>Wogonin, a flavonoid derived from the plant Scutellaria baicalinase's, has emerged as a promising candidate for sepsis management due to its multifaceted pharmacological properties. A comprehensive search of databases, including Google Scholar, Scopus, Web of Science, PubMed, and Embase, was conducted up to November 2025 using relevant keywords<i>. In-vivo</i> studies were assessed using the SYRCLE risk of bias tool, and <i>in-vitro</i> studies were evaluated with the OHAT risk of bias tool. A total of 449 articles were initially sourced, ultimately, 24 publications included in this systematic review. Evidence from various <i>in-vivo</i> and <i>in-vitro</i> studies indicates that wogonin exerts protective effects against sepsis-induced organ damage by modulating critical signalling pathways such as NF-κB, MAPK, and Nrf2/HO-1. Despite these promising findings, further clinical trials are necessary to establish the safety and efficacy of wogonin in human subjects suffering from sepsis.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1080/14786419.2026.2622548
Muhammad Aurang Zeb, Xiao-Ying Ruan, Xing-Jie Zhang, Yu-Tong Xing, Meng-Ru Wang, Yuan-Lin Kong, Xiao-Li Li, Kai Jiang, Wei-Lie Xiao
A phytochemical investigation of Callicarpa integerrima resulted in the isolation of two previously undescribed clerodane diterpenoids, compounds 1 and 2, in addition to four known compounds (3-6). Structural determination of the new compounds was accomplished through a comprehensive investigation of their spectral data (1D and 2D NMR, HR-ESI-MS and UV/IR), and their absolute configurations were assigned by the comparison of the experimental and calculated ECD curves, supported by specific rotation data. LDH release in J774A.1 macrophages was used to evaluate the anti-inflammatory effects of compounds 1-6. Compound 2 revealed remarkable activity, with an IC50 of 5.12 ± 0.24 µM, compared to andrographolide (IC50 of 12.48 ± 0.60 µM), effectively inhibiting lipopolysaccharide and nigericin-induced pyroptosis in a dose-dependent manner, highlighting its potential as a promising NLRP3 inflammasome inhibitor for further development.
{"title":"Two new clerodane diterpenoids and their anti-inflammatory activity from <i>Callicarpa integerrima</i>.","authors":"Muhammad Aurang Zeb, Xiao-Ying Ruan, Xing-Jie Zhang, Yu-Tong Xing, Meng-Ru Wang, Yuan-Lin Kong, Xiao-Li Li, Kai Jiang, Wei-Lie Xiao","doi":"10.1080/14786419.2026.2622548","DOIUrl":"https://doi.org/10.1080/14786419.2026.2622548","url":null,"abstract":"<p><p>A phytochemical investigation of <i>Callicarpa integerrima</i> resulted in the isolation of two previously undescribed clerodane diterpenoids, compounds <b>1</b> and <b>2</b>, in addition to four known compounds (<b>3-6</b>). Structural determination of the new compounds was accomplished through a comprehensive investigation of their spectral data (1D and 2D NMR, HR-ESI-MS and UV/IR), and their absolute configurations were assigned by the comparison of the experimental and calculated ECD curves, supported by specific rotation data. LDH release in J774A.1 macrophages was used to evaluate the anti-inflammatory effects of compounds <b>1-6</b>. Compound <b>2</b> revealed remarkable activity, with an IC<sub>50</sub> of 5.12 ± 0.24 µM, compared to andrographolide (IC<sub>50</sub> of 12.48 ± 0.60 µM), effectively inhibiting lipopolysaccharide and nigericin-induced pyroptosis in a dose-dependent manner, highlighting its potential as a promising NLRP3 inflammasome inhibitor for further development.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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