Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2230343
From the EtOAc-soluble extract of the rhizomes of Zingiber montanum (J.Koenig) Link ex A.Dietr., a novel diphenylbutenoid, montadinin A (1) and a previously unreported phenylbutenoid compound, 1-(3,4-dimethoxyphenyl)but-3-en-2-ol (7), in natural source were isolated. Additionally, seven known phenylbutenoids were also identified. The structures of all compounds were elucidated through NMR spectroscopic interpretation. Compounds cis-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene (2), cis-4-[(E)-3,4-dimethoxystyryl]-3-(2,4,5-trimethoxyphenyl)cyclohex-1-ene (3), trans-3-(3,4,-dimethoxyphenyl)-4-[(E)-2,4,5-trimethoxystyryl]cyclohex-1-ene (5), and cis-3-(3,4-dimethoxyphenyl)-4-[(Z)-2,4,5-trimethoxylstyryl]cyclohex-1-ene (6) showed weak cytotoxicity against HepG2 cells with IC50 values of 122.9, 127.3, 257.5, and 168.5 µM, respectively.
从蒙脱宁（Zingiber montanum (J.Koenig) Link ex A.Dietr.）根茎的乙酸乙酯可溶性提取物中分离出了一种新的二苯基类丁烯化合物蒙脱宁 A（1）和一种以前未报道过的天然来源的苯丁烯化合物 1-(3,4-二甲氧基苯基)丁-3-烯-2-醇（7）。此外，还发现了七种已知的苯丁烯化合物。所有化合物的结构都通过核磁共振光谱分析得到了阐明。化合物顺式-3-(3,4-二甲氧基苯基)-4-[(E)-3,4-二甲氧基苯乙烯基]环己-1-烯（2）、顺式-4-[(E)-3,4-二甲氧基苯乙烯基]-3-(2,4,5-三甲氧基苯基)环己-1-烯（3）、反式-3-(3,4,-二甲氧基苯基)-4-[(E)-2、反式-3-(3,4,-二甲氧基苯基)-4-[(E)-2,4,5-三甲氧基苯乙烯基]环己-1-烯 (5)和顺式-3-(3,4-二甲氧基苯基)-4-[(Z)-2,4,5-三甲氧基苯乙烯基]环己-1-烯 (6)对 HepG2 细胞表现出微弱的细胞毒性，IC50 值分别为 122.9、127.3、257.5 和 168.5 µM。
{"title":"A novel diphenylbutenoid-type compound from the rhizomes of Zingiber montanum (J.Koenig) Link ex A.Dietr. (Zingiberaceae)","authors":"","doi":"10.1080/14786419.2023.2230343","DOIUrl":"10.1080/14786419.2023.2230343","url":null,"abstract":"<div><div>From the EtOAc-soluble extract of the rhizomes of <em>Zingiber montanum</em> (J.Koenig) Link ex A.Dietr., a novel diphenylbutenoid, montadinin A (<strong>1</strong>) and a previously unreported phenylbutenoid compound, 1-(3,4-dimethoxyphenyl)but-3-en-2-ol (<strong>7</strong>), in natural source were isolated. Additionally, seven known phenylbutenoids were also identified. The structures of all compounds were elucidated through NMR spectroscopic interpretation. Compounds <em>cis</em>-3-(3,4-dimethoxyphenyl)-4-[(<em>E</em>)-3,4-dimethoxystyryl]cyclohex-1-ene (<strong>2</strong>), <em>cis</em>-4-[(<em>E</em>)-3,4-dimethoxystyryl]-3-(2,4,5-trimethoxyphenyl)cyclohex-1-ene (<strong>3</strong>), <em>trans</em>-3-(3,4,-dimethoxyphenyl)-4-[(<em>E</em>)-2,4,5-trimethoxystyryl]cyclohex-1-ene (<strong>5</strong>), and <em>cis</em>-3-(3,4-dimethoxyphenyl)-4-[(<em>Z</em>)-2,4,5-trimethoxylstyryl]cyclohex-1-ene (<strong>6</strong>) showed weak cytotoxicity against HepG2 cells with IC<sub>50</sub> values of 122.9, 127.3, 257.5, and 168.5 <em>µ</em>M, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2218009
A phytochemical investigation of the methanolic extract of aerial parts of the Acanthus ilicifolius led to the isolation of two new lignan glycosides, acaniliciosides A and B (1 and 2), together with ten known compounds (3-12). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound 12, other compounds inhibited NO production in LPS activated RAW264.7 cells with IC50 values of 2.14-28.18 µM, as potent as that of the positive control of NG-monomethyl-L-arginine acetate (L-NMMA, IC50 of 32.50 µM). In addition, compounds 5-8 showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC50 values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC50 values ranging from 1.23 to 1.46 μM.
{"title":"Two new lignan glycosides from Acanthus ilicifoliusL. with their NO inhibition and cytotoxic activity","authors":"","doi":"10.1080/14786419.2023.2218009","DOIUrl":"10.1080/14786419.2023.2218009","url":null,"abstract":"<div><div>A phytochemical investigation of the methanolic extract of aerial parts of the <em>Acanthus ilicifolius</em> led to the isolation of two new lignan glycosides, acaniliciosides A and B (<strong>1</strong> and <strong>2</strong>), together with ten known compounds (<strong>3</strong>-<strong>12</strong>). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound <strong>12</strong>, other compounds inhibited NO production in LPS activated RAW264.7 cells with IC<sub>50</sub> values of 2.14-28.18 µM, as potent as that of the positive control of <em>N</em><sup>G</sup>-monomethyl-L-arginine acetate (L-NMMA, IC<sub>50</sub> of 32.50 µM). In addition, compounds <strong>5</strong>-<strong>8</strong> showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC<sub>50</sub> values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC<sub>50</sub> values ranging from 1.23 to 1.46 μM.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9893321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2228985
Aiming at confirming the chemical structure, herein, we report the crystal structure of Arbortristoside-A, isolated from the seeds of Nyctanthes arbor-tristis Linn. and investigated by single crystal X-ray crystallographic analysis. The unambiguously established structure of Arbortristoside-A not only addresses previously reported structural flaws but also encourages its chemical, computational, and physiological studies as a lead drug candidate of pharmaceutical significance.
为了确认其化学结构，我们在本文中报告了树皮苷-A 的晶体结构，该结构是从 Nyctanthes arbor-tristis Linn.的种子中分离出来的，并通过单晶 X 射线晶体分析进行了研究。明确确定的 Arbortristoside-A 结构不仅解决了之前报道的结构缺陷，还促进了其化学、计算和生理学研究，使其成为具有重要药用价值的候选先导药物。
{"title":"Isolation of Arbortristoside-A from Nyctanthes arbor-tristis seeds and its structural validation by X-ray crystallographic analysis","authors":"","doi":"10.1080/14786419.2023.2228985","DOIUrl":"10.1080/14786419.2023.2228985","url":null,"abstract":"<div><div>Aiming at confirming the chemical structure, herein, we report the crystal structure of Arbortristoside-A, isolated from the seeds of <em>Nyctanthes arbor-tristis</em> Linn. and investigated by single crystal X-ray crystallographic analysis. The unambiguously established structure of Arbortristoside-A not only addresses previously reported structural flaws but also encourages its chemical, computational, and physiological studies as a lead drug candidate of pharmaceutical significance.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2230606
Three 12, 8-guaianolide sesquiterpene lactones, including a new compound intybusin F (1), and a new natural product cichoriolide I (2), along with six known 12, 6-guaianolide compounds (4–9) were isolated from the roots of Cichorium intybus L. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of new compounds were elucidated based on analysis of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 2, 4, 7, 8 showed significant effects on facilitating the glucose uptake in oleic acid plus high glucose-stimulated HepG2 cells at 50 μM. In addition, compounds 1, 2, 3, 6, 7 exhibited obvious inhibitory effects against NO production, of them, compounds 1, 2, 7 can significantly decrease the secretion of inflammatory cytokines (TNF-α, IL-6 and COX-2) levels in this hyperglycemic HepG2 cell model.
{"title":"One new 12, 8-guaianolide sesquiterpene lactone with antihyperglycemic activity from the roots of Cichorium intybus","authors":"","doi":"10.1080/14786419.2023.2230606","DOIUrl":"10.1080/14786419.2023.2230606","url":null,"abstract":"<div><div>Three 12, 8-guaianolide sesquiterpene lactones, including a new compound intybusin F (<strong>1</strong>), and a new natural product cichoriolide I (<strong>2</strong>), along with six known 12, 6-guaianolide compounds (<strong>4</strong>–<strong>9</strong>) were isolated from the roots of <em>Cichorium intybus</em> L. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of new compounds were elucidated based on analysis of the experimental and calculated electronic circular dichroism spectra. Compounds <strong>1</strong>, <strong>2</strong>, <strong>4</strong>, <strong>7</strong>, <strong>8</strong> showed significant effects on facilitating the glucose uptake in oleic acid plus high glucose-stimulated HepG2 cells at 50 μM. In addition, compounds <strong>1</strong>, <strong>2</strong>, <strong>3</strong>, <strong>6</strong>, <strong>7</strong> exhibited obvious inhibitory effects against NO production, of them, compounds <strong>1</strong>, <strong>2</strong>, <strong>7</strong> can significantly decrease the secretion of inflammatory cytokines (TNF-α, IL-6 and COX-2) levels in this hyperglycemic HepG2 cell model.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10099597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2215906
Angelica is a large genus of plants belonging to the Apiaceae family that includes about 100 species of biennial or perennial herbs. Several species of this genus are extensively used in various traditional medicines and, despite their content in toxic furanocoumarins, also as food. In this study, the chemical composition of the essential oil (EO) from aerial flowering parts of Angelica sylvestris L., a plant distributed in Europe, North and Central Asia, collected in the Isle of Skey (Scotland), was analyzed by GC and GC-MS. No one report has been previously published on this accession. The result showed the presence of a large quantity of monoterpene hydrocarbons with limonene (51.89%), by far, as the most abundant component. Other metabolites present in lesser quantity were β-pinene (4.61%), α-pinene (3.54%), and thymol (3.33%). Considerations with respect to all the other EOs of A. sylvestris taxa, studied so far, were carried out.
{"title":"Angelica sylvestris L. (Apiaceae) of the Isle of Skye (Scotland): chemical composition of essential oil from the aerial flowering parts","authors":"","doi":"10.1080/14786419.2023.2215906","DOIUrl":"10.1080/14786419.2023.2215906","url":null,"abstract":"<div><div><em>Angelica</em> is a large genus of plants belonging to the Apiaceae family that includes about 100 species of biennial or perennial herbs. Several species of this genus are extensively used in various traditional medicines and, despite their content in toxic furanocoumarins, also as food. In this study, the chemical composition of the essential oil (EO) from aerial flowering parts of <em>Angelica sylvestris</em> L., a plant distributed in Europe, North and Central Asia, collected in the Isle of Skey (Scotland), was analyzed by GC and GC-MS. No one report has been previously published on this accession. The result showed the presence of a large quantity of monoterpene hydrocarbons with limonene (51.89%), by far, as the most abundant component. Other metabolites present in lesser quantity were <em>β</em>-pinene (4.61%), <em>α-</em>pinene (3.54%), and thymol (3.33%). Considerations with respect to all the other EOs of <em>A. sylvestris</em> taxa, studied so far, were carried out.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9528085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2218530
Hypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1-3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and C exhibited strong inhibitory effects on L. pseudotheobromae with IC50 value at the concentration of 1.01 and 2.40 μg/mL, respectively. Compound 6 showed medium antifungal activity with IC50 value at the concentration of 10.67 μg/mL on Fusarium oxysporum. Compounds 3 and 4 displayed medium antifungul effects on Candida albicans.
{"title":"Three new furanones from endophytic fungus Hypoxylon vinosopulvinatum DYR-1-7 from Cinnamomum cassia with their antifungal activity","authors":"","doi":"10.1080/14786419.2023.2218530","DOIUrl":"10.1080/14786419.2023.2218530","url":null,"abstract":"<div><div><em>Hypoxylon vinosopulvinatum</em> DYR-1-7 is a endophytic fungus isolated from the <em>Cinnamomum cassia</em> Presl and has an inhibitory effect on <em>Lasiodiplodia pseudotheobromae</em>. Three new furanones, hypoxylonone A-C (<strong>1</strong>-<strong>3</strong>), as well as three known compounds (<strong>4</strong>-<strong>6</strong>), were isolated from an EtOAc extract of <em>H. vinosopulvinatum</em> DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of <strong>1</strong>-<strong>3</strong> were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and <strong>C</strong> exhibited strong inhibitory effects on <em>L. pseudotheobromae</em> with IC<sub>50</sub> value at the concentration of 1.01 and 2.40 μg/mL, respectively. Compound <strong>6</strong> showed medium antifungal activity with IC<sub>50</sub> value at the concentration of 10.67 μg/mL on <em>Fusarium oxysporum</em>. Compounds <strong>3</strong> and <strong>4</strong> displayed medium antifungul effects on <em>Candida albicans</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9556684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2228459
Pistacia chinensis subsp. integerrima is a valuable medicinal plant as its parts and extracts found application for treating diarrhea, fever, liver disorders, asthma, and inflammation. In this study, we report the leishmanicidal activity of sakuranetin, spinacetin, and patuletin extracted from P. chinensis. The tested compounds revealed a strong anti-leishmanial activity in vitro against Leishmania major showing IC50 values of 7.98 ± 0.16 µM, 9.23 ± 0.23 µM 11.09 ± 0.87 µM for sakuranetin, spinacetin, and patuletin, respectively. Moreover, to explore the potential mechanism(s) by which the compounds may act, computational docking studies were performed against dihydrofolate reductase and pteridine reductase, showing that the flavonoids could target these two key enzymes to exploit their leishmanicidal activity. In accordance with in vitro results, patuletin was highlighted as the most promising compound of the set, and binding energy values of −6.72 and −6.74 kcal/mol were computed for the two proteins, respectively.
{"title":"Flavonoids from Pistacia chinensis subsp. integerrima with leishmanicidal activity: computational and experimental evidence","authors":"","doi":"10.1080/14786419.2023.2228459","DOIUrl":"10.1080/14786419.2023.2228459","url":null,"abstract":"<div><div><em>Pistacia chinensis</em> subsp. <em>integerrima</em> is a valuable medicinal plant as its parts and extracts found application for treating diarrhea, fever, liver disorders, asthma, and inflammation. In this study, we report the leishmanicidal activity of sakuranetin, spinacetin, and patuletin extracted from <em>P. chinensis</em>. The tested compounds revealed a strong anti-leishmanial activity <em>in vitro</em> against <em>Leishmania major</em> showing IC<sub>50</sub> values of 7.98 ± 0.16 µM, 9.23 ± 0.23 µM 11.09 ± 0.87 µM for sakuranetin, spinacetin, and patuletin, respectively. Moreover, to explore the potential mechanism(s) by which the compounds may act, computational docking studies were performed against dihydrofolate reductase and pteridine reductase, showing that the flavonoids could target these two key enzymes to exploit their leishmanicidal activity. In accordance with <em>in vitro</em> results, patuletin was highlighted as the most promising compound of the set, and binding energy values of −6.72 and −6.74 kcal/mol were computed for the two proteins, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2230342
The genus Phagnalon Cass. (Asteraceae) is widely distributed from Macaronesia in the West to the Himalayas in the East, from South France and Nord Italy to Ethiopia and Arabian Peninsula. Species of this genus have been used in folk medicine of many countries as medicinal herbs and they are also used such as food. The extracts and the essential oils (EOs) of these plants have reported antimicrobial, antioxidant, antidiabetic, antitumor, etc. properties and they have different biological applications. Phagnalon sinaicum Bornm. and Kneuck. is a very rare plant native of Middle East. It grows primarily in the desert or dry scrubland biome. Its EO, never previously investigated, was analysed by GC-MS. The EO was very rich in oxygenated monoterpenes, with artemisia ketone (20.40%), α-thujone (19.36%), and santolina alcohol (13.29%) as main constituent. Some considerations with respect to all the other EOs of Phagnalon taxa studied so far were carried out.
{"title":"The chemical composition of the aerial parts essential oil of Phagnalon sinaicum collected in the Negev Desert (Israel)","authors":"","doi":"10.1080/14786419.2023.2230342","DOIUrl":"10.1080/14786419.2023.2230342","url":null,"abstract":"<div><div>The genus <em>Phagnalon</em> Cass. (Asteraceae) is widely distributed from Macaronesia in the West to the Himalayas in the East, from South France and Nord Italy to Ethiopia and Arabian Peninsula. Species of this genus have been used in folk medicine of many countries as medicinal herbs and they are also used such as food. The extracts and the essential oils (EOs) of these plants have reported antimicrobial, antioxidant, antidiabetic, antitumor, etc. properties and they have different biological applications. <em>Phagnalon sinaicum</em> Bornm. and Kneuck. is a very rare plant native of Middle East. It grows primarily in the desert or dry scrubland biome. Its EO, never previously investigated, was analysed by GC-MS. The EO was very rich in oxygenated monoterpenes, with artemisia ketone (20.40%), <em>α</em>-thujone (19.36%), and santolina alcohol (13.29%) as main constituent. Some considerations with respect to all the other EOs of <em>Phagnalon</em> taxa studied so far were carried out.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10116588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural products can provide versatile substructures with potential bioactivity and biocompatibility for exploring bioactive compounds. Herein, to explore novel natural product-derived antifungal a...
Pub Date : 2024-09-16DOI: 10.1080/14786419.2023.2217467
From the MeOH residue of Barringtonia macrocarpa branches and leaves, one new isoryanodane diterpene, barringisol (1), and two new isoryanodane diterpene glucosides, barringisosides A and B (2 and 3), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from Barringtonia species. Moreover, the in vitro cytotoxicity of 1−3 on three human cancer cell lines (HepG2, LNCaP and MCF7) was also accessed using SRB assays.
{"title":"Isoryanodane diterpene derivatives from Barringtonia macrocarpa","authors":"","doi":"10.1080/14786419.2023.2217467","DOIUrl":"10.1080/14786419.2023.2217467","url":null,"abstract":"<div><div>From the MeOH residue of <em>Barringtonia macrocarpa</em> branches and leaves, one new isoryanodane diterpene, barringisol (<strong>1</strong>), and two new isoryanodane diterpene glucosides, barringisosides A and B (<strong>2</strong> and <strong>3</strong>), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from <em>Barringtonia</em> species. Moreover, the <em>in vitro</em> cytotoxicity of <strong>1</strong>−<strong>3</strong> on three human cancer cell lines (HepG2, LNCaP and MCF7) was also accessed using SRB assays.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9540654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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