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Diffraction order-engineered polarization-dependent silicon nano-antennas metagrating for compact subtissue Mueller microscopy 紧凑型亚组织穆勒显微镜的衍射顺序工程极化依赖硅纳米天线偏转
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-12-03 DOI: 10.1515/nanoph-2025-0405
Qingyuan Li, Jianyao Li, Gaodi Chen, Zhiguang Lin, Dongmei Lu, Xiaoxu Deng
A polarization-dependent silicon nano-antennas metagrating (PSNM) is proposed for parallel polarization transformation by engineering diffraction orders, upon which a compact Mueller microscopy system is implemented for subtissue-level polarization extraction. The polarization-dependent metagrating is designed using matrix Fourier optics and nonlinear optimization with four diffraction orders described by waveplate-like Jones matrices, which is encoded by nano-antennas combining geometric and propagation phases. The measured phase delay and orientation of each diffraction order of the metagrating deviate by less than 6.7 % from the design values, and the overall diffraction efficiency reaches 70.89 % with a coefficient of variation of 0.021. A transmissive PSNM Mueller microscopy system is developed by directly embedding the metagrating into an infinity-corrected microscopic optical path, which extracts subtissue-level polarization distributions of biological sections over a 152 μm × 152 μm field of view with reduced measurement redundancy, facilitating the differentiation and staging of pathological tissues for potential stain-free diagnostic applications.
提出了一种极化相关的硅纳米天线偏转(PSNM),通过工程衍射顺序实现平行极化变换,并在此基础上实现了紧凑的穆勒显微镜系统,用于亚组织级极化提取。利用矩阵傅里叶光学和非线性优化技术设计了偏振相关偏光器件,其衍射阶数由波片琼斯矩阵描述,由纳米天线结合几何相位和传播相位进行编码。测量到的偏析衍射各阶的相位延迟和取向与设计值偏差小于6.7%,整体衍射效率达到70.89%,变异系数为0.021。透射式PSNM Mueller显微镜系统通过将偏光片直接嵌入到无限远校正的显微光路中,可以在152 μm × 152 μm的视场上提取生物切片的亚组织级偏振分布,减少测量冗余,促进病理组织的分化和分期,用于潜在的无染色诊断应用。
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引用次数: 0
A comprehensive study of plasmonic mode hybridization in gold nanoparticle-over-mirror (NPoM) arrays 金纳米粒子-超镜(NPoM)阵列中等离子体模式杂化的综合研究
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-12-03 DOI: 10.1515/nanoph-2025-0437
Raphael Gherman, Sacha Schwarz, Jean-François Bryche, Guillaume Beaudin, Alex Currie, Pierre Levesque, François Fillion-Gourdeau, Steve G. MacLean, Dominique Drouin, Serge Ecoffey, Paul G. Charette
Hybrid plasmonic systems that combine localized and propagative surface plasmons offer new opportunities for tunable light–matter interactions at the nanoscale. This paper provides the most comprehensive study to date of hybridization between gap localized surface plasmons (gap LSP) and diffraction-mediated propagative surface plasmon polaritons (SPP) in arrays of gold nanodisks over a mirror, part of the larger class of nanoparticle-over-mirror (NPoM) devices. By systematically mapping the hybrid mode dispersion as a function of array geometry over a large parameter space, we extract the coupling strength via a coupled oscillator model and reveal its dependence on key structural parameters, with gap thickness identified as the primary tuning factor. The resulting hybrid modes enhance the optical quality factor by nearly fivefold compared to classical LSP while maintaining strong near-field confinement, combining the advantages of their constituent modes. Dephasing times were measured with interferometric time-resolved photoemission electron microscopy (ITR-PEEM). Using a scalable lithography-compatible NPoM architecture that minimizes the optical index mismatch between the dielectric between the nanodisks and the gap material (Al 2 O 3 ), we achieved the highest coupling strength (123 meV) and dephasing time range (23–50 fs) to date in NPoM arrays.
混合等离子体系统结合了局部和传播表面等离子体,为纳米尺度上可调谐的光-物质相互作用提供了新的机会。本文提供了迄今为止最全面的研究间隙局域表面等离子体激元(gap LSP)和衍射介导的传播表面等离子体激元(SPP)之间的杂化在镜子上的金纳米盘阵列,更大类别的纳米粒子-镜上(NPoM)器件的一部分。通过在大参数空间上系统地映射混合模式色散作为阵列几何形状的函数,我们通过耦合振荡器模型提取耦合强度,并揭示其与关键结构参数的依赖关系,并将间隙厚度确定为主要调谐因素。所得到的混合模式结合了其组成模式的优点,在保持强近场约束的同时,光学质量因子比传统LSP提高了近五倍。用干涉时间分辨光发射电子显微镜(ITR-PEEM)测量脱相时间。采用可扩展的光刻兼容NPoM架构,最大限度地减少了纳米盘和间隙材料(Al 2o3)之间介电介质的光学折射率不匹配,我们在NPoM阵列中实现了迄今为止最高的耦合强度(123 meV)和脱相时间范围(23-50 fs)。
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引用次数: 0
Large-gap cascaded Moiré metasurfaces enabling switchable bright-field and phase-contrast imaging compatible with coherent and incoherent light 大间隙级联moir<s:1>超表面,实现可切换的亮场和相衬成像,兼容相干和非相干光
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-12-01 DOI: 10.1515/nanoph-2025-0494
Yiyi Li, Wangzhe Zhou, Yuqing Zhang, Xiaoyan Huang, Yutai Chen, Man Yuan, Junbo Yang
Bright-field and phase-contrast imaging represent two of the most essential modes for target recognition and feature extraction, offering broad applicability in fields such as biomedicine and autonomous driving. In this work, we propose a cascaded Moiré metasurfaces system with a large interlayer spacing, which enables switchable bright-field and phase-contrast imaging at a wavelength of 532 nm by adjusting the illumination conditions between coherent and incoherent light sources. By employing an optimized phase-iterative algorithm, the stringent spacing requirement of conventional cascaded Moiré metasurfaces is relaxed from the subwavelength scale (∼100 nm) to beyond 1 mm, while maintaining robust imaging performance under spacing deviations of ±0.1 mm. Through controlled relative rotation of the two metasurfaces by an angle θ , the system dynamically switches between a focused solid Airy disk ( θ = 0°) and vortex beams with tunable topological charges ranging from −5 to +5 ( θ = ±20° to ±100°). The design achieves a focusing efficiency of 82 % and vortex beam purities up to 99 %. Owing to its versatile switching capability, the system supports multi-order edge extraction for both phase-type and amplitude-type objects, reaching a spatial frequency of 228 lp/mm. This approach overcomes the limitation of existing edge-detection metasurfaces, which operate only under either coherent or incoherent illumination. Our findings provide a new technical pathway toward compact, multifunctional, and integrated imaging devices.
亮场成像和相对比成像是目标识别和特征提取的两种最基本的模式,在生物医学和自动驾驶等领域具有广泛的适用性。在这项工作中,我们提出了一个具有大层间距的级联moir超表面系统,通过调整相干光源和非相干光源之间的照明条件,可以在532 nm波长下切换亮场和相对比成像。通过采用优化的相位迭代算法,传统级联moir超表面的严格间距要求从亚波长尺度(~ 100 nm)放宽到超过1 mm,同时在间距偏差为±0.1 mm的情况下保持稳健的成像性能。通过控制两个超表面的相对旋转角度θ,系统在聚焦的固体艾里盘(θ = 0°)和涡旋光束(θ =±20°至±100°)之间动态切换,拓扑电荷范围为- 5至+5。该设计实现了82%的聚焦效率和高达99%的涡束纯度。由于其多功能开关能力,该系统支持相位型和幅度型物体的多阶边缘提取,达到228 lp/mm的空间频率。该方法克服了现有边缘检测元表面只能在相干或非相干照明下工作的局限性。我们的发现为实现紧凑、多功能和集成成像设备提供了一条新的技术途径。
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引用次数: 0
Directional enhancement of photoluminescence from phosphor plates with TiO 2 nanoantenna stickers 二氧化钛纳米天线贴片对荧光板光致发光的定向增强
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-29 DOI: 10.1515/nanoph-2025-0419
Hongjie Gao, Joshua T.Y. Tse, Shunsuke Murai, Katsuhisa Tanaka
Directional illumination is critical for next-generation solid-state lighting. In this study, we demonstrate that flexible nanoantenna stickers enhance photoluminescence (PL) directionality. By integrating YAG:Ce phosphor plates and distributed Bragg reflectors (DBRs), these stickers achieve controlled radiation distribution, advancing the development of compact, high-performance illumination technologies. In addition, these stickers produce a different PL output by simply changing the thickness of the phosphor plate. The output PL intensity is doubled by placing a DBR layer on the bottom of the plate, thereby transmitting blue excitation light while reflecting yellow PL. This study provides a simple and versatile method for tuning PL from phosphor plates. This technique can serve as a fundamental tool for controlling light flow with improved efficiency.
定向照明是下一代固态照明的关键。在这项研究中,我们证明了柔性纳米天线贴纸可以增强光致发光(PL)的方向性。通过集成YAG:Ce荧光粉板和分布式布拉格反射器(DBRs),这些贴纸实现了可控的辐射分布,推动了紧凑、高性能照明技术的发展。此外,这些贴纸通过简单地改变荧光粉板的厚度来产生不同的PL输出。通过在荧光板底部放置DBR层,输出的发光强度增加了一倍,从而在反射黄色发光的同时发射蓝色激发光。本研究提供了一种简单而通用的从荧光板调谐发光的方法。这种技术可以作为控制光流的基本工具,提高效率。
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引用次数: 0
Metastructure-enabled scalable multiple mode-order converters: conceptual design and demonstration in direct-access add/drop multiplexing systems 元结构支持可扩展的多模顺序转换器:直接接入加/丢多路复用系统的概念设计和演示
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-29 DOI: 10.1515/nanoph-2025-0364
Zhenzhao Guo, Weike Zhao, Shengbao Wu, Yunfeng Lai, Shuying Cheng, Daoxin Dai
The rapid advancement of multimode photonic technologies, optical computing, and quantum circuits, leveraging higher-order modes, necessitates the development of on-chip multiple mode-order converters (MMOCs). However, existing schemes face limitations in traffic capacity, polarization-dependence, and scalability. Herein, we propose a novel highly scalable MMOC design framework enabled by subwavelength grating (SWG) metastructures. By integrating SWG arrays into a taper-tailored multimode waveguide, the design synergizes coherent scattering and beam shaping to achieve efficient target-supermode excitations and precise phase controls, simultaneously. In this way, the target MMOC can be realized according to the functional requirements of mode manipulations by optimizing the metastructures. Experimentally fabricated devices exhibit ILs < 1.85 dB and CTs < −12.5 dB across (22 or 50) nm bandwidths, with a polarization-independent quad-mode operation. Notably, the dual-pair mode exchanging MMOC pioneers simultaneous TE 0 ↔TE 2 and TE 1 ↔TE 3 , doubling exchange efficiency over conventional single-pair solutions. Integrated into a direct-access mode add/drop system (DAMAD), TE 0 /TE 1 dual-mode add/drop operations achieve ILs < 4.5 dB and CTs < −15.5 dB across 41 nm bandwidth. Thereupon, clear eye diagrams at 32/64 Gbps operations demonstrate the capability for the high-speed optical communication. The proposed concept offers a novel strategy for on-chip multiple mode manipulations, with transformative potential in higher-order modes based optical communications.
利用高阶模式的多模光子技术、光学计算和量子电路的快速发展,要求片上多模阶转换器(mmoc)的发展。然而,现有方案在流量容量、极化依赖性和可扩展性等方面存在局限性。在此,我们提出了一种基于亚波长光栅(SWG)元结构的高可扩展性MMOC设计框架。通过将SWG阵列集成到锥形多模波导中,该设计协同相干散射和波束整形,同时实现高效的目标超模激励和精确的相位控制。通过对元结构的优化,可以根据模态操作的功能需求实现目标MMOC。实验制备的器件在(22或50)nm带宽上显示出1.85 dB和- 12.5 dB的ILs和CTs,具有与偏振无关的四模操作。值得注意的是,双对模式交换MMOC率先同时↔TE 2和TE 1↔TE 3,比传统的单对解决方案的交换效率提高了一倍。集成到直接接入模式加/丢系统(DAMAD)中,te0 / te1双模加/丢操作在41 nm带宽上实现ILs <; 4.5 dB和CTs <;−15.5 dB。因此,32/64 Gbps操作下的清晰眼图展示了高速光通信的能力。提出的概念为片上多模式操作提供了一种新的策略,在基于高阶模式的光通信中具有变革潜力。
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引用次数: 0
The longitudinal dynamics evolution of optical skyrmions via meta-optics 光学陀螺的纵向动力学演化
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-29 DOI: 10.1515/nanoph-2025-0436
Tiantian He, Chang Liu, Wenxuan Tang, Dan Li, Ping Yan, Qiang Liu, Qirong Xiao
Skyrmions, as topologically structured light fields, have attracted considerable attention due to their unique topological properties and potential applications such as optical communication and advanced sensing technologies. However, their longitudinal evolution, as a dimension ripe for exploitation, typically remains uncontrolled and non-deterministic, hindering its in-depth exploration and application scenarios. Here, this paper presents a novel method using dielectric metasurfaces for precisely modeling the longitudinal dynamics evolution of skyrmions. We introduce a new mechanism that allows for the accurate period modulation of skyrmions stokes properties along the propagation direction by controlling the differences in numerical apertures of a zero-order right-circularly polarized beam and a first-order left-circularly polarized beam. Crucially, the evolution period can be arbitrarily designed, and the propagation distance can be expanded by increasing the waist radius of input beams. To validate this approach, we showcase this paradigm through displacement sensing applications, where single-snapshot polarization measurements directly infer absolute position within a compact metasurface-integrated platform, offering a compact and simple alternative to conventional scanning-based approaches for displacement sensing. Our approach advances the understanding of dynamically controlled topological light fields and enables compact devices for precision metrology and optical information technologies.
Skyrmions作为一种拓扑结构光场,由于其独特的拓扑特性以及在光通信和先进传感技术等方面的潜在应用而备受关注。然而,作为一个成熟的开发维度,它们的纵向演变通常仍然是不受控制和不确定的,阻碍了其深入的探索和应用场景。本文提出了一种利用介电超表面精确模拟粒子纵向动力学演化的新方法。我们引入了一种新的机制,通过控制零阶右圆偏振光束和一阶左圆偏振光束的数值孔径差异,可以沿着传播方向精确地调制skyrmions stokes特性。关键是,演化周期可以任意设计,并且可以通过增加输入光束的腰半径来扩大传播距离。为了验证这种方法,我们通过位移传感应用展示了这种范例,其中单快照偏振测量直接推断紧凑的超表面集成平台内的绝对位置,为传统的基于扫描的位移传感方法提供了一种紧凑而简单的替代方案。我们的方法促进了对动态控制拓扑光场的理解,并使精密计量和光学信息技术的紧凑设备成为可能。
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引用次数: 0
Segmented finger electrodes to optimize ultra-long continuous wafer-scale periodic poling in thin-film lithium niobate 在铌酸锂薄膜中优化超长连续晶圆尺度周期性极化的分段手指电极
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-29 DOI: 10.1515/nanoph-2025-0461
Laura Bollmers, Noah Spiegelberg, Michael Rüsing, Christof Eigner, Laura Padberg, Christine Silberhorn
Periodically poled thin-film lithium niobate (TFLN) crystals are the fundamental building block for highly-efficient quantum light sources and frequency converters. The efficiency of these devices is strongly dependent on the interaction length between the light and the nonlinear material, scaling quadratically with this parameter. Nevertheless, the fabrication of long, continuously poled areas in TFLN remains challenging, the length of continuously poled areas rarely exceeds 10 mm. In this work, we demonstrate a significant progress in this field achieving the periodic poling of continuous poled areas of 70 mm length with a 3 μm poling period and a close to 50 % duty cycle. We compare two poling electrode design approaches to fabricate long, continuous poled areas. The first approach involves the poling of a single, continuous 70 mm long electrode. The second utilize a segmented approach including the poling of more than 20 individual sections forming together a 70 mm long poling area with no stitching errors. While the continuous electrode allows for faster fabrication, the segmented approach allows to individually optimize the poling resulting in less duty cycle variation. A detailed analysis of the periodic poling results reveals that the results of both are consistent with previously reported poling outcomes for shorter devices. Thus, we demonstrate wafer-scale periodic poling exceeding chiplet-size without any loss in the periodic poling quality. Our work presents a key step towards highly-efficient, narrow-bandwidth and low-pump power nonlinear optical devices.
周期性极化薄膜铌酸锂(TFLN)晶体是高效量子光源和频率转换器的基本组成部分。这些器件的效率强烈依赖于光与非线性材料之间的相互作用长度,并与该参数成二次比例。然而,在TFLN中制造长、连续极化区域仍然具有挑战性,连续极化区域的长度很少超过10毫米。在这项工作中,我们展示了该领域的重大进展,实现了70 mm长度的连续极化区域的周期性极化,极化周期为3 μm,占空比接近50%。我们比较了两种极化电极设计方法来制造长,连续的极化区域。第一种方法涉及到一个单一的,连续的70毫米长的电极。第二种方法采用分段方法,包括将20多个单独的部分进行打孔,形成一个70毫米长的打孔区域,没有拼接误差。虽然连续电极允许更快的制造,但分段方法允许单独优化极化,从而减少占空比变化。对周期性轮询结果的详细分析表明,两者的结果与先前报道的较短器件的轮询结果一致。因此,我们证明了晶圆尺度的周期性极点超过晶片尺寸,而没有任何损失的周期性极点质量。我们的工作为实现高效、窄带宽和低泵浦光功率的非线性光学器件迈出了关键的一步。
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引用次数: 0
Optical see-through augmented reality via inverse-designed waveguide couplers 通过反设计波导耦合器的光学透视增强现实
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-28 DOI: 10.1515/nanoph-2025-0501
Seunghyun Lee, Byounghyo Lee, Haejun Chung
Waveguide-based augmented-reality (AR) displays offer compact, optical see-through form factors but remain limited by chromatic dispersion, ghosting from parasitic diffraction orders, distortion of the see-through scene, and a restricted eyebox. We present triple-function metasurface couplers designed using adjoint-based optimization, which overcome these limitations and establish computational performance bounds. The out-coupler simultaneously preserves zeroth-order transmission of the see-through path and directs display light into designated diffraction orders while returning residual guided power as zeroth-order reflection for eyebox expansion. The in-coupler assigns distinct diffraction orders to R/G/B and equalizes their in-plane propagation angles, achieving achromatic guidance and eliminating chromatic path divergence. Quantitatively, the optimized out-coupler provides >90 % angle-averaged zeroth-order transmission for the see-through view (10–40× lower higher-order leakage) and >95 % zeroth-order guided reflection, while maintaining efficient diffractive couplings to the eyebox. PSF/MTF analyses confirm near-diffraction-limited virtual-image quality and strong suppression of see-through view distortion. Finally, benchmarking freeform against fabrication-constrained multilayer architectures (1–6 layers) shows that multilayers approach the freeform upper bound while remaining practical to fabricate. These results outline a general, manufacturable methodology for multifunctional metasurface couplers and a practical route to compact, high-quality AR waveguides.
基于波导的增强现实(AR)显示器提供了紧凑的光学透明外形,但仍然受到色散、寄生衍射阶的重影、透明场景失真和受限眼框的限制。我们提出了基于伴随优化设计的三功能超表面耦合器,克服了这些限制并建立了计算性能界限。外耦合器同时保持透明路径的零级传输,并将显示光引导到指定的衍射阶,同时返回剩余的引导功率作为零级反射用于眼箱扩展。该耦合器为R/G/B分配不同的衍射顺序,并使它们的平面内传播角均衡,实现消色差制导和消色光程发散。在定量上,优化后的外耦合器提供了90%的角度平均零级透射(10 - 40倍低高阶泄漏)和95%的零级引导反射,同时保持了与眼箱的高效衍射耦合。PSF/MTF分析证实了近衍射限制的虚拟图像质量和对透视视图失真的强烈抑制。最后,针对制造受限的多层架构(1-6层)对自由形式进行基准测试表明,多层结构接近自由形式的上限,同时保持实用的制造。这些结果概述了多功能超表面耦合器的一般可制造方法,以及紧凑,高质量AR波导的实用途径。
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引用次数: 0
Inverse-designed gyrotropic scatterers for non-reciprocal analog computing 用于非互反模拟计算的反设计陀螺散射体
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-28 DOI: 10.1515/nanoph-2025-0247
Nikolas Hadjiantoni, Heedong Goh, Stephen M. Hanham, Miguel Navarro-Cía, Andrea Alù
While conventional von Neumann based machines are increasingly challenged by modern day requirements, electromagnetic analog computing devices promise to provide a platform that is highly parallel, efficient and fast. Along this paradigm, it has been shown that arrays of subwavelength electromagnetic scatterers can be used as solvers of partial differential equations. Inverse design offers a powerful tool to synthesize such analog computing machines, utilizing engineered non-local responses to produce the solution of a desired mathematical operation encoded in the scattered fields. So far, this approach has been largely restricted to linear, reciprocal scatterers, limiting its generality and applicability. Here we demonstrate how arrays of gyrotropic scatterers can be used to solve a more general class of differential equations. Through inverse design, with a combination of evolutionary and gradient based algorithms, the position of the scatterers is optimized to achieve the desired kernel response. Introducing gyrotropic media, we also demonstrate improved accuracy by >2 orders of magnitude compared to similarly sized reciprocal systems designed with the same method.
虽然传统的基于冯·诺依曼的机器日益受到现代需求的挑战,但电磁模拟计算设备有望提供一个高度并行、高效和快速的平台。沿着这一范式,已经证明亚波长电磁散射体阵列可以用作偏微分方程的求解器。逆设计提供了一个强大的工具来合成这样的模拟计算机器,利用工程的非局部响应来产生在散射场中编码的所需数学运算的解。到目前为止,这种方法主要局限于线性、互反散射体,限制了它的通用性和适用性。在这里,我们演示了如何使用陀螺散射体阵列来求解一类更一般的微分方程。通过逆向设计,结合进化算法和梯度算法,优化散射体的位置,以获得理想的核响应。通过引入旋向介质,我们还证明了与用相同方法设计的类似尺寸的互易系统相比,精度提高了2个数量级。
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引用次数: 0
High-sensitivity U-shaped biosensor for rabbit IgG detection based on PDA/AuNPs/PDA sandwich structure 基于PDA/AuNPs/PDA夹层结构的兔IgG高灵敏度u型生物传感器
IF 7.5 2区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2025-11-28 DOI: 10.1515/nanoph-2025-0367
Pengxiang Chang, Yirui Zhang, Ailing Zhang, Zhen Li, Zhiyang Wang, Yanmei Shi
Combining the advantages of polydopamine (PDA), gold nanoparticles (AuNPs), and U-shaped optical fibers, a PDA/AuNPs/PDA sandwich structure modified U-shaped optical fiber surface plasmon resonance (SPR) biosensor was proposed and used for the detection of rabbit IgG. The U-shaped structure significantly enhances the penetration depth of the evanescent field. The PDA/AuNPs/PDA sandwich structure boosts coupling efficiency of SPR and LSPR, increases the specific surface area of the sensor, and improves surface activity. The experimental results show that the refractive index (RI) sensitivity of the sensor is 6,206.32 nm/RIU in the RI range of 1.3353–1.3595, which is 1.63 times higher than the raw U-shaped sensor. The biosensor for detection of rabbit IgG achieved a biosensitivity of 0.153 nm/(ng/mL), which is two orders of magnitude higher and a limit of detection (LOD) of 0.131 ng/mL, which is one order of magnitude lower. The outstanding performance of the proposed biosensor offers a new solution for the detection of low-concentration biological solutions, and it has great potential applications in the field of medical diagnosis.
结合聚多巴胺(PDA)、金纳米粒子(AuNPs)和u型光纤的优点,提出了一种PDA/AuNPs/PDA夹层结构修饰的u型光纤表面等离子体共振(SPR)生物传感器,并将其用于兔IgG的检测。u型结构显著增强了倏逝场的穿透深度。PDA/AuNPs/PDA夹层结构提高了SPR和LSPR的耦合效率,增加了传感器的比表面积,提高了表面活性。实验结果表明,该传感器在1.3353 ~ 1.3595的折射率(RI)范围内的灵敏度为6206.32 nm/RIU,是原始u型传感器的1.63倍。该传感器检测兔IgG的生物灵敏度为0.153 nm/(ng/mL),提高了两个数量级,检出限(LOD)为0.131 ng/mL,降低了一个数量级。该传感器的优异性能为低浓度生物溶液的检测提供了新的解决方案,在医学诊断领域具有巨大的应用潜力。
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引用次数: 0
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