Pub Date : 2026-01-27DOI: 10.1038/s41893-025-01763-x
Linking humans, animals, plants, environments and ecosystems to forge healthier lives on a healthier planet clearly aligns with sustainability objectives. A collection of research and opinion presents ideas on the way forward to support such alignment.
{"title":"One Health synergies","authors":"","doi":"10.1038/s41893-025-01763-x","DOIUrl":"10.1038/s41893-025-01763-x","url":null,"abstract":"Linking humans, animals, plants, environments and ecosystems to forge healthier lives on a healthier planet clearly aligns with sustainability objectives. A collection of research and opinion presents ideas on the way forward to support such alignment.","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"9 1","pages":"1-2"},"PeriodicalIF":27.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41893-025-01763-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The excessive use of antimicrobials has led to increasing levels of antimicrobial resistance that can spread between livestock, humans and the environment, with important One Health implications. Antimicrobial use in the livestock sector represents 73% of global antimicrobial consumption, yet how such antimicrobial use is embedded within international trade and global production networks remains unclear. Here we quantify global antimicrobial footprints and trace them through global supply chains from 2010 to 2020. Global livestock antimicrobial footprints peaked at 118.6 kilotons (kt) in 2013, then fell to 84.0 kt by 2020. China and the USA contributed nearly 60% of the global antimicrobial footprint. Most use remained in domestically produced goods, yet the trade-embodied share rose from 16% to 20%, signalling growing cross-border spillovers. Developed economies showed higher per capita use via trade, whereas developing economies’ use was concentrated in local production. Brazil surpassed China as the largest exporter of antimicrobials used in livestock production by 2020. Intriguingly, non-food products, particularly the clothing, services and manufacturing sectors, account for half of the trade-embodied antimicrobial footprint. Thus, global spillover of the effects of antimicrobial use extends well beyond the food system thus requiring policymakers to broaden their focus to better address antimicrobial resistance threats. Excessive antimicrobial use can increase the threat of antimicrobial resistance; however, how such use is embedded in global trade is still unclear. Authors here estimate global livestock antimicrobial footprints through global supply chains to better understand and manage antimicrobial use.
{"title":"Livestock antimicrobial use embodied in global supply chains","authors":"Junya Zhang, Baiwen Ma, Xiangping Hu, Qingling Wang, Kailan Tian, Martin Bruckner, Jing Meng, Priti Parikh, Shen Qu, Chengzhi Hu, Yuansong Wei, Heran Zheng","doi":"10.1038/s41893-025-01751-1","DOIUrl":"10.1038/s41893-025-01751-1","url":null,"abstract":"The excessive use of antimicrobials has led to increasing levels of antimicrobial resistance that can spread between livestock, humans and the environment, with important One Health implications. Antimicrobial use in the livestock sector represents 73% of global antimicrobial consumption, yet how such antimicrobial use is embedded within international trade and global production networks remains unclear. Here we quantify global antimicrobial footprints and trace them through global supply chains from 2010 to 2020. Global livestock antimicrobial footprints peaked at 118.6 kilotons (kt) in 2013, then fell to 84.0 kt by 2020. China and the USA contributed nearly 60% of the global antimicrobial footprint. Most use remained in domestically produced goods, yet the trade-embodied share rose from 16% to 20%, signalling growing cross-border spillovers. Developed economies showed higher per capita use via trade, whereas developing economies’ use was concentrated in local production. Brazil surpassed China as the largest exporter of antimicrobials used in livestock production by 2020. Intriguingly, non-food products, particularly the clothing, services and manufacturing sectors, account for half of the trade-embodied antimicrobial footprint. Thus, global spillover of the effects of antimicrobial use extends well beyond the food system thus requiring policymakers to broaden their focus to better address antimicrobial resistance threats. Excessive antimicrobial use can increase the threat of antimicrobial resistance; however, how such use is embedded in global trade is still unclear. Authors here estimate global livestock antimicrobial footprints through global supply chains to better understand and manage antimicrobial use.","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"9 1","pages":"65-76"},"PeriodicalIF":27.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1038/s41893-025-01753-z
Ishi Keenum, Thomas U. Berendonk, Jonas Bonnedahl, Eddie Cytryn, Christophe Dagot, Antti Karkman, Despo Fatta-Kassinos, April Hayes, Alexander Kirschner, Jan-Ulrich Kreft, Célia M. Manaia, Christophe Merlin, Naziza Rahman, Holly Tipper, Máté Vass, Arthur Zastepa, EDAR7 Working Group
Antimicrobial resistance (AMR) represents a major One Health issue, driven by a myriad of potential accelerators that include emerging climate and social challenges. There is little doubt about the need for interventions at critical control points to reduce AMR, but addressing AMR within a single realm of One Health (for example, human, animal or environmental) is not sufficient to reduce it. Building on the past decade of research, this Perspective highlights comprehensive, systemic and integrative strategies that address the effects of anthropogenic activities and the complex relationship between humans and the environment as key targets for intersectoral and global action. Antimicrobial resistance continues to be a critical One Health challenge, despite research and policy progress. Building on the past decade of research, this Perspective provides an integrative roadmap for addressing antimicrobial resistance by leveraging the complexities of human and environment interactions.
{"title":"Towards One Health action for addressing antimicrobial resistance in the age of polycrisis","authors":"Ishi Keenum, Thomas U. Berendonk, Jonas Bonnedahl, Eddie Cytryn, Christophe Dagot, Antti Karkman, Despo Fatta-Kassinos, April Hayes, Alexander Kirschner, Jan-Ulrich Kreft, Célia M. Manaia, Christophe Merlin, Naziza Rahman, Holly Tipper, Máté Vass, Arthur Zastepa, EDAR7 Working Group","doi":"10.1038/s41893-025-01753-z","DOIUrl":"10.1038/s41893-025-01753-z","url":null,"abstract":"Antimicrobial resistance (AMR) represents a major One Health issue, driven by a myriad of potential accelerators that include emerging climate and social challenges. There is little doubt about the need for interventions at critical control points to reduce AMR, but addressing AMR within a single realm of One Health (for example, human, animal or environmental) is not sufficient to reduce it. Building on the past decade of research, this Perspective highlights comprehensive, systemic and integrative strategies that address the effects of anthropogenic activities and the complex relationship between humans and the environment as key targets for intersectoral and global action. Antimicrobial resistance continues to be a critical One Health challenge, despite research and policy progress. Building on the past decade of research, this Perspective provides an integrative roadmap for addressing antimicrobial resistance by leveraging the complexities of human and environment interactions.","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"9 1","pages":"24-34"},"PeriodicalIF":27.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1038/s41893-025-01749-9
Moreno Di Marco, Lara Marcolin, Andrea Tonelli, Eloise Skinner, Elena Catucci
Outbreaks of zoonotic pathogens have become more frequent as human modification of the natural environment accelerates pathogen spillover from wildlife to humans, yet much remains to be investigated around the mechanisms that regulate pathogen outbreaks. This Review explores the current use of macroecological variables (that is, emergent ecosystem properties) for modelling zoonotic disease risk. We identify important research gaps and discuss untapped opportunities for using a wider spectrum of variables to achieve improved modelling of zoonotic disease risk and, consequently, surveillance. We present a set of operational recommendations and guidelines for potential integration of macroecological approaches within a broader One Health framework. In recent decades, zoonotic disease outbreaks have become increasingly frequent, necessitating strategies to improve the accuracy of predictive modelling. This Review discusses the importance of macroecological variables in such modelling efforts to improve preparedness for future potential outbreaks.
{"title":"Macroecological approaches for the prediction of zoonotic disease risk","authors":"Moreno Di Marco, Lara Marcolin, Andrea Tonelli, Eloise Skinner, Elena Catucci","doi":"10.1038/s41893-025-01749-9","DOIUrl":"10.1038/s41893-025-01749-9","url":null,"abstract":"Outbreaks of zoonotic pathogens have become more frequent as human modification of the natural environment accelerates pathogen spillover from wildlife to humans, yet much remains to be investigated around the mechanisms that regulate pathogen outbreaks. This Review explores the current use of macroecological variables (that is, emergent ecosystem properties) for modelling zoonotic disease risk. We identify important research gaps and discuss untapped opportunities for using a wider spectrum of variables to achieve improved modelling of zoonotic disease risk and, consequently, surveillance. We present a set of operational recommendations and guidelines for potential integration of macroecological approaches within a broader One Health framework. In recent decades, zoonotic disease outbreaks have become increasingly frequent, necessitating strategies to improve the accuracy of predictive modelling. This Review discusses the importance of macroecological variables in such modelling efforts to improve preparedness for future potential outbreaks.","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"9 1","pages":"35-45"},"PeriodicalIF":27.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1038/s41893-025-01750-2
Adam Fell, Soushieta Jagadesh, A. Bradley Duthie, Luci Kirkpatrick, Nils Bunnefeld
The COVID-19 pandemic has spotlighted the growing threat of zoonotic diseases, often exacerbated by land-use changes such as deforestation and habitat fragmentation. We conducted a systematic literature review (2000–2024) to assess how different types of land-use change affect zoonotic disease transmission, summarizing key findings and trends in geographic focus on the vectors/hosts/reservoirs and pathogens studied, in addition to identifying research gaps. We also evaluated the potential of restoration interventions to mitigate disease risks. Our analysis shows that land-use changes such as deforestation and urbanization often increase transmission risks, particularly for diseases transmitted by mosquitos and rodents, while some restoration strategies (for example, reforestation and wetland conservation) can reduce these risks. However, effects vary by disease group and region. The literature remains geographically biased, with most studies concentrated in wealthier regions despite higher disease burdens in low-income areas. We propose 50 high-priority locations, primarily in Western Africa and Southeast Asia, for future research. Our findings are available through an open-access online atlas, which includes supporting case studies and policy briefs to inform One Health-oriented restoration planning. Land-use change, among other anthropogenic factors, has led to increased levels of zoonotic disease transmission. The authors assess how land-use change and restoration activities impact zoonotic disease transmission, providing an online tool useful for One Health-oriented restoration planning.
{"title":"Global evidence synthesis on land-use change and zoonotic risks","authors":"Adam Fell, Soushieta Jagadesh, A. Bradley Duthie, Luci Kirkpatrick, Nils Bunnefeld","doi":"10.1038/s41893-025-01750-2","DOIUrl":"10.1038/s41893-025-01750-2","url":null,"abstract":"The COVID-19 pandemic has spotlighted the growing threat of zoonotic diseases, often exacerbated by land-use changes such as deforestation and habitat fragmentation. We conducted a systematic literature review (2000–2024) to assess how different types of land-use change affect zoonotic disease transmission, summarizing key findings and trends in geographic focus on the vectors/hosts/reservoirs and pathogens studied, in addition to identifying research gaps. We also evaluated the potential of restoration interventions to mitigate disease risks. Our analysis shows that land-use changes such as deforestation and urbanization often increase transmission risks, particularly for diseases transmitted by mosquitos and rodents, while some restoration strategies (for example, reforestation and wetland conservation) can reduce these risks. However, effects vary by disease group and region. The literature remains geographically biased, with most studies concentrated in wealthier regions despite higher disease burdens in low-income areas. We propose 50 high-priority locations, primarily in Western Africa and Southeast Asia, for future research. Our findings are available through an open-access online atlas, which includes supporting case studies and policy briefs to inform One Health-oriented restoration planning. Land-use change, among other anthropogenic factors, has led to increased levels of zoonotic disease transmission. The authors assess how land-use change and restoration activities impact zoonotic disease transmission, providing an online tool useful for One Health-oriented restoration planning.","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"9 1","pages":"142-152"},"PeriodicalIF":27.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1038/s41893-025-01752-0
Nayoung Kim, Daniel S. Collins, Nina M. Donghia, Benjamin S. Miller, Hani M. Sallum, Silvi R. Lybbert, Elena Perini, James B. Niemi, James J. Collins, Peter Q. Nguyen
Ocean ecosystems are undergoing accelerating disruption from human impacts such as climate change. Warming ocean temperatures drive pathogenic outbreaks, increase harmful algal blooms and cause coral stress. These can have serious consequences for marine ecosystems, human health and the aquaculture industry, representing a critical One Health issue. Monitoring key marine species offers valuable insights, but current methods are resource-intensive, low-resolution and unsuitable for frequent deployment. Here we introduce a low-cost, field-deployable CRISPR biosensing platform for detecting marine organismal DNA and RNA. Harnessing the programmability of CRISPR diagnostics for environmental biosurveillance, we demonstrate versatility across three climate-linked indicators: Vibrio spp., Pseudo-nitzschia spp. and heat-stressed corals. Portable 3D-printed processor and incubator devices enable direct processing of filter-captured samples with temperature control. Field readiness is reinforced by lyophilized reagents, lateral flow readouts, dropper-based handling and a two-step multiplexed workflow, delivering results within 1 hour without laboratory instruments. Benchmarking with authentic pathogens and environmental seawater confirmed seawater tolerance and robust detection of 108 colony-forming units per filter of Vibrio pathogens, equivalent to 102 copies per microlitre for 1 litre of filtered sample. This decentralized platform reduces barriers to routine monitoring and can provide early warnings of ecosystem disturbances, while supporting One Health initiatives in the marine space. Human impacts on marine ecosystems are increasing the likelihood of pathogenic outbreaks, harmful algal blooms and coral stress. Here the authors develop a CRISPR biomonitoring tool that can help detect key marine species that are important to public health, the aquaculture sector and marine ecosystems.
{"title":"A field‑deployable CRISPR-based biosensing platform for monitoring marine ecosystems","authors":"Nayoung Kim, Daniel S. Collins, Nina M. Donghia, Benjamin S. Miller, Hani M. Sallum, Silvi R. Lybbert, Elena Perini, James B. Niemi, James J. Collins, Peter Q. Nguyen","doi":"10.1038/s41893-025-01752-0","DOIUrl":"10.1038/s41893-025-01752-0","url":null,"abstract":"Ocean ecosystems are undergoing accelerating disruption from human impacts such as climate change. Warming ocean temperatures drive pathogenic outbreaks, increase harmful algal blooms and cause coral stress. These can have serious consequences for marine ecosystems, human health and the aquaculture industry, representing a critical One Health issue. Monitoring key marine species offers valuable insights, but current methods are resource-intensive, low-resolution and unsuitable for frequent deployment. Here we introduce a low-cost, field-deployable CRISPR biosensing platform for detecting marine organismal DNA and RNA. Harnessing the programmability of CRISPR diagnostics for environmental biosurveillance, we demonstrate versatility across three climate-linked indicators: Vibrio spp., Pseudo-nitzschia spp. and heat-stressed corals. Portable 3D-printed processor and incubator devices enable direct processing of filter-captured samples with temperature control. Field readiness is reinforced by lyophilized reagents, lateral flow readouts, dropper-based handling and a two-step multiplexed workflow, delivering results within 1 hour without laboratory instruments. Benchmarking with authentic pathogens and environmental seawater confirmed seawater tolerance and robust detection of 108 colony-forming units per filter of Vibrio pathogens, equivalent to 102 copies per microlitre for 1 litre of filtered sample. This decentralized platform reduces barriers to routine monitoring and can provide early warnings of ecosystem disturbances, while supporting One Health initiatives in the marine space. Human impacts on marine ecosystems are increasing the likelihood of pathogenic outbreaks, harmful algal blooms and coral stress. Here the authors develop a CRISPR biomonitoring tool that can help detect key marine species that are important to public health, the aquaculture sector and marine ecosystems.","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"9 1","pages":"51-64"},"PeriodicalIF":27.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1038/s41893-025-01746-y
Angelos Alamanos
{"title":"Combining water and carbon footprint","authors":"Angelos Alamanos","doi":"10.1038/s41893-025-01746-y","DOIUrl":"10.1038/s41893-025-01746-y","url":null,"abstract":"","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"8 12","pages":"1411-1411"},"PeriodicalIF":27.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145772828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1038/s41893-025-01737-z
Stephanie M. Olen
{"title":"Carbon conflicts in ocean fisheries","authors":"Stephanie M. Olen","doi":"10.1038/s41893-025-01737-z","DOIUrl":"10.1038/s41893-025-01737-z","url":null,"abstract":"","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"8 12","pages":"1415-1415"},"PeriodicalIF":27.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145772760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1038/s41893-025-01709-3
Matej Zlatar, Tatiana Priamushko
Water electrolysis powered by renewable energy is a promising technology to produce green hydrogen, but widespread adoption is hindered by the lack of stable, low-cost catalysts coping with the fluctuations of renewable sources. Now a study shows such an electrocatalyst that works across a wide voltage range.
{"title":"Harvesting intermittent energy","authors":"Matej Zlatar, Tatiana Priamushko","doi":"10.1038/s41893-025-01709-3","DOIUrl":"10.1038/s41893-025-01709-3","url":null,"abstract":"Water electrolysis powered by renewable energy is a promising technology to produce green hydrogen, but widespread adoption is hindered by the lack of stable, low-cost catalysts coping with the fluctuations of renewable sources. Now a study shows such an electrocatalyst that works across a wide voltage range.","PeriodicalId":19056,"journal":{"name":"Nature Sustainability","volume":"8 12","pages":"1439-1440"},"PeriodicalIF":27.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145772834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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