Pub Date : 2024-11-20DOI: 10.1038/s41562-024-02012-5
Dulcie Newbury
{"title":"Why we need an archaeology of menstruation","authors":"Dulcie Newbury","doi":"10.1038/s41562-024-02012-5","DOIUrl":"10.1038/s41562-024-02012-5","url":null,"abstract":"","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"8 11","pages":"2079-2080"},"PeriodicalIF":21.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-20DOI: 10.1038/s41562-024-02014-3
A. J. Lowik
Many trans people menstruate, yet they are often ignored in discourses around menstruation. A.J. Lowik, a trans person and reproductive health researcher, explains why this needs to change.
{"title":"Why we should care about trans people and menstruation","authors":"A. J. Lowik","doi":"10.1038/s41562-024-02014-3","DOIUrl":"10.1038/s41562-024-02014-3","url":null,"abstract":"Many trans people menstruate, yet they are often ignored in discourses around menstruation. A.J. Lowik, a trans person and reproductive health researcher, explains why this needs to change.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"8 11","pages":"2081-2082"},"PeriodicalIF":21.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41562-024-02014-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-19DOI: 10.1038/s41562-024-02062-9
Felix Holzmeister, Magnus Johannesson, Colin F. Camerer, Yiling Chen, Teck-Hua Ho, Suzanne Hoogeveen, Juergen Huber, Noriko Imai, Taisuke Imai, Lawrence Jin, Michael Kirchler, Alexander Ly, Benjamin Mandl, Dylan Manfredi, Gideon Nave, Brian A. Nosek, Thomas Pfeiffer, Alexandra Sarafoglou, Rene Schwaiger, Eric-Jan Wagenmakers, Viking Waldén, Anna Dreber
Here we test the feasibility of using decision markets to select studies for replication and provide evidence about the replicability of online experiments. Social scientists (n = 162) traded on the outcome of close replications of 41 systematically selected MTurk social science experiments published in PNAS 2015–2018, knowing that the 12 studies with the lowest and the 12 with the highest final market prices would be selected for replication, along with 2 randomly selected studies. The replication rate, based on the statistical significance indicator, was 83% for the top-12 and 33% for the bottom-12 group. Overall, 54% of the studies were successfully replicated, with replication effect size estimates averaging 45% of the original effect size estimates. The replication rate varied between 54% and 62% for alternative replication indicators. The observed replicability of MTurk experiments is comparable to that of previous systematic replication projects involving laboratory experiments. This study finds that decision markets can be a useful tool for selecting studies for replication. For a sample of 26 online experiments published in PNAS selected by a decision market, the authors find replication rates ranging between 54% and 62%.
{"title":"Examining the replicability of online experiments selected by a decision market","authors":"Felix Holzmeister, Magnus Johannesson, Colin F. Camerer, Yiling Chen, Teck-Hua Ho, Suzanne Hoogeveen, Juergen Huber, Noriko Imai, Taisuke Imai, Lawrence Jin, Michael Kirchler, Alexander Ly, Benjamin Mandl, Dylan Manfredi, Gideon Nave, Brian A. Nosek, Thomas Pfeiffer, Alexandra Sarafoglou, Rene Schwaiger, Eric-Jan Wagenmakers, Viking Waldén, Anna Dreber","doi":"10.1038/s41562-024-02062-9","DOIUrl":"10.1038/s41562-024-02062-9","url":null,"abstract":"Here we test the feasibility of using decision markets to select studies for replication and provide evidence about the replicability of online experiments. Social scientists (n = 162) traded on the outcome of close replications of 41 systematically selected MTurk social science experiments published in PNAS 2015–2018, knowing that the 12 studies with the lowest and the 12 with the highest final market prices would be selected for replication, along with 2 randomly selected studies. The replication rate, based on the statistical significance indicator, was 83% for the top-12 and 33% for the bottom-12 group. Overall, 54% of the studies were successfully replicated, with replication effect size estimates averaging 45% of the original effect size estimates. The replication rate varied between 54% and 62% for alternative replication indicators. The observed replicability of MTurk experiments is comparable to that of previous systematic replication projects involving laboratory experiments. This study finds that decision markets can be a useful tool for selecting studies for replication. For a sample of 26 online experiments published in PNAS selected by a decision market, the authors find replication rates ranging between 54% and 62%.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 2","pages":"316-330"},"PeriodicalIF":21.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41562-024-02062-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-19DOI: 10.1038/s41562-024-02067-4
S. Shyam Sundar, Eugene Cho Snyder, Mengqi Liao, Junjun Yin, Jinping Wang, Guangqing Chi
Social media have enabled laypersons to disseminate, at scale, links to news and public affairs information. Many individuals share such links without first reading the linked information. Here we analysed over 35 million public Facebook posts with uniform resource locators shared between 2017 and 2020, and discovered that such ‘shares without clicks’ (SwoCs) constitute around 75% of forwarded links. Extreme and user-aligned political content received more SwoCs, with partisans engaging in it more than politically neutral users. In addition, analyses with 2,969 false uniform resource locators revealed higher shares and, hence, SwoCs by conservatives (76.94%) than liberals (14.25%), probably because, in our dataset, the vast majority (76–82%) of them originated from conservative news domains. Findings suggest that the virality of political content on social media (including misinformation) is driven by superficial processing of headlines and blurbs rather than systematic processing of core content, which has design implications for promoting deliberate discourse in the online public sphere. Over 75% of links to news shared on Facebook during the election seasons of 2017–2020 were forwarded without the sharer first clicking on them. Extreme and user-aligned political content was shared more, aiding the spread of partisan misinformation.
{"title":"Sharing without clicking on news in social media","authors":"S. Shyam Sundar, Eugene Cho Snyder, Mengqi Liao, Junjun Yin, Jinping Wang, Guangqing Chi","doi":"10.1038/s41562-024-02067-4","DOIUrl":"10.1038/s41562-024-02067-4","url":null,"abstract":"Social media have enabled laypersons to disseminate, at scale, links to news and public affairs information. Many individuals share such links without first reading the linked information. Here we analysed over 35 million public Facebook posts with uniform resource locators shared between 2017 and 2020, and discovered that such ‘shares without clicks’ (SwoCs) constitute around 75% of forwarded links. Extreme and user-aligned political content received more SwoCs, with partisans engaging in it more than politically neutral users. In addition, analyses with 2,969 false uniform resource locators revealed higher shares and, hence, SwoCs by conservatives (76.94%) than liberals (14.25%), probably because, in our dataset, the vast majority (76–82%) of them originated from conservative news domains. Findings suggest that the virality of political content on social media (including misinformation) is driven by superficial processing of headlines and blurbs rather than systematic processing of core content, which has design implications for promoting deliberate discourse in the online public sphere. Over 75% of links to news shared on Facebook during the election seasons of 2017–2020 were forwarded without the sharer first clicking on them. Extreme and user-aligned political content was shared more, aiding the spread of partisan misinformation.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 1","pages":"156-168"},"PeriodicalIF":21.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41562-024-02048-7
Yan Luo, Paul Siu Fai Yip, Qingpeng Zhang
The Internet is increasingly important in addressing age-related mental health challenges. We used linear mixed models and meta-analyses to examine the association between Internet use and mental health among 87,559 adults aged ≥50 years from 23 countries. Internet use was associated with fewer depressive symptoms (pooled average marginal effect (AME), −0.09; 95% confidence interval (CI), −0.12 to −0.07), higher life satisfaction (pooled AME, 0.07; 95% CI, 0.05 to 0.10) and better self-reported health (pooled AME, 0.15; 95% CI, 0.12 to 0.17). For two countries (the USA and England) with genetic data available, positive associations between Internet use and mental health were observed across three genetic risk categories. For three countries (the USA, England and China), a higher frequency of Internet use was related to better mental health. Our findings are relevant to public health policies and practices in promoting mental health in later life through the Internet, especially in countries with limited Internet access and mental health services. Luo et al. examine data from adults aged ≥50 years across 23 countries and find that Internet use is associated with reduced depressive symptoms, higher life satisfaction and better self-reported health.
{"title":"Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries","authors":"Yan Luo, Paul Siu Fai Yip, Qingpeng Zhang","doi":"10.1038/s41562-024-02048-7","DOIUrl":"10.1038/s41562-024-02048-7","url":null,"abstract":"The Internet is increasingly important in addressing age-related mental health challenges. We used linear mixed models and meta-analyses to examine the association between Internet use and mental health among 87,559 adults aged ≥50 years from 23 countries. Internet use was associated with fewer depressive symptoms (pooled average marginal effect (AME), −0.09; 95% confidence interval (CI), −0.12 to −0.07), higher life satisfaction (pooled AME, 0.07; 95% CI, 0.05 to 0.10) and better self-reported health (pooled AME, 0.15; 95% CI, 0.12 to 0.17). For two countries (the USA and England) with genetic data available, positive associations between Internet use and mental health were observed across three genetic risk categories. For three countries (the USA, England and China), a higher frequency of Internet use was related to better mental health. Our findings are relevant to public health policies and practices in promoting mental health in later life through the Internet, especially in countries with limited Internet access and mental health services. Luo et al. examine data from adults aged ≥50 years across 23 countries and find that Internet use is associated with reduced depressive symptoms, higher life satisfaction and better self-reported health.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 1","pages":"90-100"},"PeriodicalIF":21.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41562-024-02060-x
Jonah Koetke, Karina Schumann, Shauna M. Bowes, Nina Vaupotič
Public trust in scientists is critical to our ability to face societal threats. Here, across five pre-registered studies (N = 2,034), we assessed whether perceptions of scientists’ intellectual humility affect perceived trustworthiness of scientists and their research. In study 1, we found that seeing scientists as higher in intellectual humility was associated with greater perceived trustworthiness of scientists and support for science-based beliefs. We then demonstrated that describing a scientist as high (versus low) in intellectual humility increased perceived trustworthiness of the scientist (studies 2–4), belief in their research (studies 2–4), intentions to follow their research-based recommendations (study 3) and information-seeking behaviour (study 4). We further demonstrated that these effects were not moderated by the scientist’s gender (study 3) or race/ethnicity (study 4). In study 5, we experimentally tested communication approaches that scientists can use to convey intellectual humility. These studies reveal the benefits of seeing scientists as intellectually humble across medical, psychological and climate science topics. Across five pre-registered studies, Koetke et al. find that perceptions of scientists’ intellectual humility positively affect the perceived trustworthiness of scientists and their research.
{"title":"The effect of seeing scientists as intellectually humble on trust in scientists and their research","authors":"Jonah Koetke, Karina Schumann, Shauna M. Bowes, Nina Vaupotič","doi":"10.1038/s41562-024-02060-x","DOIUrl":"10.1038/s41562-024-02060-x","url":null,"abstract":"Public trust in scientists is critical to our ability to face societal threats. Here, across five pre-registered studies (N = 2,034), we assessed whether perceptions of scientists’ intellectual humility affect perceived trustworthiness of scientists and their research. In study 1, we found that seeing scientists as higher in intellectual humility was associated with greater perceived trustworthiness of scientists and support for science-based beliefs. We then demonstrated that describing a scientist as high (versus low) in intellectual humility increased perceived trustworthiness of the scientist (studies 2–4), belief in their research (studies 2–4), intentions to follow their research-based recommendations (study 3) and information-seeking behaviour (study 4). We further demonstrated that these effects were not moderated by the scientist’s gender (study 3) or race/ethnicity (study 4). In study 5, we experimentally tested communication approaches that scientists can use to convey intellectual humility. These studies reveal the benefits of seeing scientists as intellectually humble across medical, psychological and climate science topics. Across five pre-registered studies, Koetke et al. find that perceptions of scientists’ intellectual humility positively affect the perceived trustworthiness of scientists and their research.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 2","pages":"331-344"},"PeriodicalIF":21.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41562-024-02050-z
Yao Yao, Erdan Dong
Mental health disorders among older adults rose during the COVID-19 pandemic, and have since continued to increase. A recent study provides timely insights into a positive association between internet use and mental wellbeing among adults aged 50 and older across 23 countries, which highlights the potential of digital technology for addressing these challenges.
{"title":"Internet use and mental wellbeing in older adults","authors":"Yao Yao, Erdan Dong","doi":"10.1038/s41562-024-02050-z","DOIUrl":"10.1038/s41562-024-02050-z","url":null,"abstract":"Mental health disorders among older adults rose during the COVID-19 pandemic, and have since continued to increase. A recent study provides timely insights into a positive association between internet use and mental wellbeing among adults aged 50 and older across 23 countries, which highlights the potential of digital technology for addressing these challenges.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 1","pages":"24-25"},"PeriodicalIF":21.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41562-024-02053-w
Bjørn-Atle Reme, Ole Røgeberg, Fartein Ask Torvik
Young adults from low socioeconomic backgrounds face an increased risk of early mortality. Here we utilize population-wide data from 17 Norwegian birth cohorts (N = 986,573) to assess whether this risk gradient was explained by early-life educational performance, specifically grade point average at 16 years of age. We show that the gradients in both parental education and income largely disappeared when adjusting for school performance in the models. Specifically, among boys, those with the lowest parental education had an unadjusted hazard ratio (HR) of 2.04 (95% confidence interval (CI) 1.86–2.22) compared with peers with the highest parental education, while for girls, the HR was 1.64 (95% CI 1.35–1.93). After adjusting for school performance, these estimates dropped to 0.99 (95% CI 0.79–1.19) for boys and 0.87 (95% CI 0.55–1.19) for girls. Similarly, the mortality risk for those from the lowest parental income quartile decreased from 1.79 (95% CI 1.67–1.91) to 1.25 (95% CI 1.12–1.38) for boys and from 1.63 (95% CI 1.44–1.83) to 1.24 (95% CI 1.03–1.46) for girls. Low educational performance remained strongly associated with early mortality in analyses accounting for unobserved heterogeneity at the family level; boys with a grade point average in the lowest quartile had an HR of 3.04 (95% CI 2.38–3.89), while for girls, the HR was 1.79 (95% CI 1.22–2.63). External causes of death, particularly accidents and poisoning, were most overrepresented among individuals with poor school performance. This study, using population-wide data from Norway, found that school performance was a stronger predictor of young adult death than parental education or earnings and largely explained the socioeconomic gradient in early mortality.
来自低社会经济背景的年轻人面临着更高的早期死亡风险。在此，我们利用挪威17个出生队列（N = 986,573）的全人口数据，评估这种风险梯度是否可以用早年的教育表现（特别是16岁时的平均学分绩点）来解释。我们的研究表明，如果在模型中对学校成绩进行调整，父母教育程度和收入的梯度在很大程度上就会消失。具体来说，在男孩中，与父母教育程度最高的同龄人相比，父母教育程度最低的男孩的未调整危险比（HR）为 2.04（95% 置信区间（CI）为 1.86-2.22），而女孩的危险比为 1.64（95% 置信区间（CI）为 1.35-1.93）。在对学校成绩进行调整后，男孩的估计值降至 0.99（95% CI 0.79-1.19），女孩的估计值降至 0.87（95% CI 0.55-1.19）。同样，来自父母最低收入四分位数的男孩的死亡风险从 1.79（95% CI 1.67-1.91）降至 1.25（95% CI 1.12-1.38），女孩的死亡风险从 1.63（95% CI 1.44-1.83）降至 1.24（95% CI 1.03-1.46）。在考虑家庭层面未观察到的异质性的分析中，教育程度低仍与早期死亡密切相关；平均成绩处于最低四分位数的男孩的 HR 为 3.04（95% CI 2.38-3.89），而女孩的 HR 为 1.79（95% CI 1.22-2.63）。外部死因，尤其是意外事故和中毒，在学习成绩差的人中比例最高。
{"title":"School performance and the social gradient in young adult death in Norway","authors":"Bjørn-Atle Reme, Ole Røgeberg, Fartein Ask Torvik","doi":"10.1038/s41562-024-02053-w","DOIUrl":"10.1038/s41562-024-02053-w","url":null,"abstract":"Young adults from low socioeconomic backgrounds face an increased risk of early mortality. Here we utilize population-wide data from 17 Norwegian birth cohorts (N = 986,573) to assess whether this risk gradient was explained by early-life educational performance, specifically grade point average at 16 years of age. We show that the gradients in both parental education and income largely disappeared when adjusting for school performance in the models. Specifically, among boys, those with the lowest parental education had an unadjusted hazard ratio (HR) of 2.04 (95% confidence interval (CI) 1.86–2.22) compared with peers with the highest parental education, while for girls, the HR was 1.64 (95% CI 1.35–1.93). After adjusting for school performance, these estimates dropped to 0.99 (95% CI 0.79–1.19) for boys and 0.87 (95% CI 0.55–1.19) for girls. Similarly, the mortality risk for those from the lowest parental income quartile decreased from 1.79 (95% CI 1.67–1.91) to 1.25 (95% CI 1.12–1.38) for boys and from 1.63 (95% CI 1.44–1.83) to 1.24 (95% CI 1.03–1.46) for girls. Low educational performance remained strongly associated with early mortality in analyses accounting for unobserved heterogeneity at the family level; boys with a grade point average in the lowest quartile had an HR of 3.04 (95% CI 2.38–3.89), while for girls, the HR was 1.79 (95% CI 1.22–2.63). External causes of death, particularly accidents and poisoning, were most overrepresented among individuals with poor school performance. This study, using population-wide data from Norway, found that school performance was a stronger predictor of young adult death than parental education or earnings and largely explained the socioeconomic gradient in early mortality.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 1","pages":"84-89"},"PeriodicalIF":21.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-11DOI: 10.1038/s41562-024-02040-1
Daniel B. Rosoff, Josephin Wagner, Andrew S. Bell, Lucas A. Mavromatis, Jeesun Jung, Falk W. Lohoff
Integrating proteomic and transcriptomic data with genetic architectures of problematic alcohol use and alcohol consumption behaviours can advance our understanding and help identify therapeutic targets. We conducted systematic screens using genome-wise association study data from ~3,500 cortical proteins (N = 722) and ~6,100 genes in 8 canonical brain cell types (N = 192) with 4 alcohol-related outcomes (N ≤ 537,349), identifying 217 cortical proteins and 255 cell-type genes associated with these behaviours, with 36 proteins and 37 cell-type genes being new. Although there was limited overlap between proteome and transcriptome targets, downstream neuroimaging revealed shared neurophysiological pathways. Colocalization with independent genome-wise association study data further prioritized 16 proteins, including CAB39L and NRBP1, and 12 cell-type genes, implicating mechanisms such as mTOR signalling. In addition, genes such as SAMHD1, VIPAS39, NUP160 and INO80E were identified as having favourable neuropsychiatric profiles. These findings provide insights into the genetic landscapes governing problematic alcohol use and alcohol consumption behaviours, highlighting promising therapeutic targets for future research. This study examines links between genetics and alcohol use, and identifies 217 proteins in the human cortex and 255 genes at single-cell resolution. Leveraging population genetics with proteomic and transcriptomic data opens new paths in addiction science.
{"title":"A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking","authors":"Daniel B. Rosoff, Josephin Wagner, Andrew S. Bell, Lucas A. Mavromatis, Jeesun Jung, Falk W. Lohoff","doi":"10.1038/s41562-024-02040-1","DOIUrl":"10.1038/s41562-024-02040-1","url":null,"abstract":"Integrating proteomic and transcriptomic data with genetic architectures of problematic alcohol use and alcohol consumption behaviours can advance our understanding and help identify therapeutic targets. We conducted systematic screens using genome-wise association study data from ~3,500 cortical proteins (N = 722) and ~6,100 genes in 8 canonical brain cell types (N = 192) with 4 alcohol-related outcomes (N ≤ 537,349), identifying 217 cortical proteins and 255 cell-type genes associated with these behaviours, with 36 proteins and 37 cell-type genes being new. Although there was limited overlap between proteome and transcriptome targets, downstream neuroimaging revealed shared neurophysiological pathways. Colocalization with independent genome-wise association study data further prioritized 16 proteins, including CAB39L and NRBP1, and 12 cell-type genes, implicating mechanisms such as mTOR signalling. In addition, genes such as SAMHD1, VIPAS39, NUP160 and INO80E were identified as having favourable neuropsychiatric profiles. These findings provide insights into the genetic landscapes governing problematic alcohol use and alcohol consumption behaviours, highlighting promising therapeutic targets for future research. This study examines links between genetics and alcohol use, and identifies 217 proteins in the human cortex and 255 genes at single-cell resolution. Leveraging population genetics with proteomic and transcriptomic data opens new paths in addiction science.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"9 1","pages":"188-207"},"PeriodicalIF":21.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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