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Advanced material technologies for space and terrestrial medicine 用于太空和地面医学的先进材料技术
IF 79.8 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-06-03 DOI: 10.1038/s41578-024-00691-0
Corrine Ying Xuan Chua, Miguel Jimenez, Maedeh Mozneb, Giovanni Traverso, Ray Lugo, Arun Sharma, Clive N. Svendsen, William R. Wagner, Robert Langer, Alessandro Grattoni
The medical risks of spaceflight are amplified as humans venture into longer-duration and greater-distance deep space voyages. During space missions, astronauts face the extremes of known health hazards, such as cosmic radiation and microgravity, as well as threats of the as-yet-unknown. For these missions to be productive and successful, ensuring the astronauts’ safety and well-being is of foremost priority, and this could be achieved through innovations in space medicine. This Perspective explores the use of material technologies for delivery of space medicine in the context of health maintenance and preventive care, as well as treatment for non-emergency and emergency needs. We highlight innovative drug delivery systems, living pharmacies, regenerative medicine, and 3D printing and bioprinting approaches for health-care provision, and we share our vision on their potential applications in space. Finally, we discuss the benefits of space medicine research and its implications for advancing terrestrial health care. Space exploration amplifies medical risks to human health. Innovation in space medicine, drug delivery, regenerative medicine and 3D printing is key for astronaut health. This Perspective explores advanced material technologies for space health care and their applicability to terrestrial medicine.
随着人类进入持续时间更长、距离更远的深空航行,航天飞行的医疗风险也随之增大。在执行太空任务期间,宇航员要面对宇宙辐射和微重力等已知的极端健康危害,以及尚未知晓的威胁。要使这些任务富有成效并取得成功,确保宇航员的安全和健康是重中之重,而这可以通过空间医学的创新来实现。本视角探讨了在健康维护和预防保健以及非紧急和紧急治疗需求的背景下利用材料技术提供太空医疗的问题。我们重点介绍了创新药物输送系统、活体药房、再生医学、3D 打印和生物打印等提供医疗保健的方法,并分享了我们对这些方法在太空中潜在应用的看法。最后,我们讨论了太空医学研究的益处及其对推进地面医疗保健的影响。
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引用次数: 0
A microscopic perspective on moiré materials 摩尔纹材料的微观视角
IF 79.8 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-31 DOI: 10.1038/s41578-024-00682-1
Kevin P. Nuckolls, Ali Yazdani
Contemporary quantum materials research is guided by themes of topology and electronic correlations. A confluence of these two themes is engineered in moiré materials, an emerging class of highly tunable, strongly correlated 2D materials designed by the rotational or lattice misalignment of atomically thin crystals. In moiré materials, dominant Coulomb interactions among electrons give rise to collective electronic phases, often with robust topological properties. Identifying the mechanisms responsible for these exotic phases is fundamental to our understanding of strongly interacting quantum systems and to our ability to engineer new material properties for potential future technological applications. In this Review, we highlight the contributions of local spectroscopic, thermodynamic and electromagnetic probes to the budding field of moiré materials research. These techniques have not only identified many of the underlying mechanisms of the correlated insulators, generalized Wigner crystals, unconventional superconductors, moiré ferroelectrics and topological orbital ferromagnets found in moiré materials, but have also uncovered fragile quantum phases that have evaded spatially averaged global probes. Furthermore, we highlight recently developed local probe techniques, including local charge sensing and quantum interference probes, that have uncovered new physical observables in moiré materials. Moiré materials are an emerging class of strongly correlated quantum materials designed by the rotational or lattice misalignment of 2D crystals. This Review discusses how local probe techniques are uniquely positioned to elucidate the microscopic mechanisms underlying the electronic phases in moiré materials.
当代量子材料研究以拓扑学和电子相关性为主题。摩尔纹材料是这两个主题的交汇点,它是一类新兴的高度可调、强相关的二维材料,由原子薄晶体的旋转或晶格错位设计而成。在摩尔纹材料中,电子间占主导地位的库仑相互作用产生了集体电子相,通常具有强大的拓扑特性。要了解强相互作用量子系统,并为未来潜在的技术应用设计出具有新特性的材料,确定这些奇特相位的形成机制至关重要。在这篇综述中,我们将重点介绍局部光谱、热力学和电磁探针对摩尔纹材料研究这一新兴领域的贡献。这些技术不仅确定了摩尔纹材料中发现的相关绝缘体、广义维格纳晶体、非常规超导体、摩尔纹铁电和拓扑轨道铁磁体的许多基本机制,还发现了躲避空间平均全局探测的脆弱量子相。此外,我们还重点介绍了最近开发的局部探测技术,包括局部电荷感应和量子干涉探测,这些技术揭示了摩尔纹材料中新的物理观测指标。
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引用次数: 0
Towards edible robots and robotic food 实现可食用机器人和机器人食品
IF 79.8 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-28 DOI: 10.1038/s41578-024-00688-9
Dario Floreano, Bokeon Kwak, Markéta Pankhurst, Jun Shintake, Mario Caironi, Valerio F. Annese, Qiukai Qi, Jonathan Rossiter, Remko M. Boom
Edible robots and robotic food — edible systems that perceive, process and act upon stimulation — could open a new range of opportunities in health care, environmental management and the promotion of healthier eating habits. For example, they could enable precise drug delivery and in vivo health monitoring, deliver autonomously targeted nutrition in emergency situations, reduce waste in farming, facilitate wild animal vaccination and produce novel gastronomical experiences. Here, we take a robot designer perspective to identify edible materials that could serve as functional components of edible robots and robotic food, such as bodies, actuators, sensors, and computational components and energy sources, describe recent examples of integration, and discuss the open challenges in the field. Edible robots and robotic food that perceive, process and react to stimuli offer opportunities to develop new medical applications, emergency food-delivery systems, waste-reduction strategies in farming and novel gastronomic experiences. This Perspective surveys edible materials that can be used to manufacture robotic components and discusses examples of edible robots and robotic food.
可食用机器人和机器人食品--能够感知、处理刺激并根据刺激采取行动的可食用系统--可以在医疗保健、环境管理和促进更健康的饮食习惯方面带来一系列新的机遇。例如,它们可以实现精确给药和体内健康监测,在紧急情况下自主提供有针对性的营养,减少农业生产中的浪费,促进野生动物疫苗接种,并带来新奇的美食体验。在此,我们将从机器人设计师的角度出发,确定可作为可食用机器人和机器人食品功能组件的可食用材料,如机体、致动器、传感器、计算组件和能源,介绍最近的集成实例,并讨论该领域的公开挑战。
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引用次数: 0
Engineering nanomaterials for glioblastoma nanovaccination 用于胶质母细胞瘤纳米疫苗的工程纳米材料
IF 79.8 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-23 DOI: 10.1038/s41578-024-00684-z
Fatima Hameedat, Bárbara B. Mendes, João Conniot, Leonardo D. Di Filippo, Marlus Chorilli, Avi Schroeder, João Conde, Flávia Sousa
Glioblastoma is a lethal brain cancer with treatment resistance stemming from its interactions with the surrounding microenvironment and obstacles such as the blood–brain barrier. Conventional therapies such as surgery and chemotherapy have shown limited efficacy, whereas immunotherapies, effective in other solid cancers, face obstacles in glioblastoma owing to its unique immunological dysfunction. Despite the development of peptide, neoantigen, cell-based and mRNA-based vaccines, progress to advanced clinical trials has been sluggish. Factors contributing to this slow progress include the immunosuppressive microenvironment of the tumour, the presence of the blood–brain barrier and the inherent instability of glioblastoma vaccines, collectively hindering treatment efficacy. In this context, nanomaterials have emerged as promising owing to their capacity to cross the blood–brain barrier, shield therapeutics from degradation and efficiently target the brain. In this Perspective, we highlight the development of glioblastoma nanovaccination, discussing strategies for nanoparticle engineering to breach the blood–brain barrier and target both immune and glioblastoma cells, paving the way for potential breakthroughs in glioblastoma treatment. Developing vaccines for glioblastoma remains challenging owing to the immunosuppressive microenvironment of the tumour and the presence of the blood–brain barrier. In this Perspective, we explore how nanomaterials can be tailored to address the limitations of glioblastoma vaccination, potentially paving the way for important advancements.
胶质母细胞瘤是一种致命的脑癌,其耐药性源于它与周围微环境的相互作用以及血脑屏障等障碍。手术和化疗等传统疗法的疗效有限,而对其他实体瘤有效的免疫疗法则因其独特的免疫功能障碍而在胶质母细胞瘤中面临障碍。尽管开发出了多肽疫苗、新抗原疫苗、细胞疫苗和 mRNA 疫苗,但临床试验进展缓慢。导致进展缓慢的因素包括肿瘤的免疫抑制微环境、血脑屏障的存在以及胶质母细胞瘤疫苗固有的不稳定性,这些因素共同阻碍了治疗效果。在这种情况下,纳米材料因其能够穿过血脑屏障、保护治疗药物不被降解并有效靶向大脑而大有可为。在本《视角》中,我们将重点介绍胶质母细胞瘤纳米疫苗的发展,讨论纳米粒子工程的策略,以突破血脑屏障,靶向免疫细胞和胶质母细胞瘤细胞,为胶质母细胞瘤治疗的潜在突破铺平道路。
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引用次数: 0
Making electronic circuits with hydrogels 用水凝胶制作电子电路
IF 83.5 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-21 DOI: 10.1038/s41578-024-00692-z
Charlotte Allard
An article in Science presents the design of a hydrogel with n-type semiconducting properties.
科学》杂志上的一篇文章介绍了一种具有 n 型半导体特性的水凝胶的设计。
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引用次数: 0
Rapid advances enabling high-performance inverted perovskite solar cells 实现高性能反相包晶石太阳能电池的快速进展
IF 83.5 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-17 DOI: 10.1038/s41578-024-00678-x
Qi Jiang, Kai Zhu
Perovskite solar cells (PSCs) that have a positive–intrinsic–negative (p–i–n, or often referred to as inverted) structure are becoming increasingly attractive for commercialization owing to their rapid increase in power conversion efficiency, easily scalable fabrication, reliable operation and compatibility with various perovskite-based tandem device configurations. Here, we review key material and device considerations for making highly efficient and stable p–i–n PSCs. First, we summarize key advances in charge transport materials, which were critical to the rapid power conversion efficiency progress. Second, we discuss promising perovskite compositions and fabrication methods. We highlight various additive engineering approaches to improve the perovskite layer as well as interface engineering strategies that target either the buried or top perovskite surface layer. Third, we review progress in tandem devices, focusing on optimization of the interconnection layer. Next, we summarize the status and strategies for improving p–i–n PSC stability, especially considering the challenges of outdoor applications. We also provide prospects for future research directions and challenges. Inverted (p–i–n) perovskite solar cells are promising candidates for real-life applications. This Review discusses the current status of this technology, key strategies for stability and efficiency improvements — from the materials selection to interface engineering and device construction — and future outlooks.
具有正-内-负(p-i-n,或通常称为倒置)结构的过氧化物太阳能电池(PSCs)由于其功率转换效率的快速提高、易于扩展的制造工艺、可靠的运行以及与各种基于过氧化物的串联器件配置的兼容性,正变得越来越具有商业化的吸引力。在此,我们回顾了制造高效稳定 pi-i-n PSCs 的关键材料和器件注意事项。首先,我们总结了电荷传输材料方面的主要进展,这些进展对于快速提高功率转换效率至关重要。其次,我们讨论了前景广阔的过氧化物成分和制造方法。我们重点介绍了改进包晶石层的各种添加工程方法,以及针对埋层或顶部包晶石表层的界面工程策略。第三,我们回顾了串联器件方面的进展,重点关注互连层的优化。接下来,我们总结了提高 pi-n PSC 稳定性的现状和策略,特别是考虑到户外应用的挑战。我们还展望了未来的研究方向和挑战。
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引用次数: 0
Using oxides to compute with heat 使用氧化物计算热量
IF 79.8 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-17 DOI: 10.1038/s41578-024-00690-1
Guillaume F. Nataf, Sebastian Volz, Jose Ordonez-Miranda, Jorge Íñiguez-González, Riccardo Rurali, Brahim Dkhil
One of the most innovative possibilities offered by oxides is the use of heat currents for computational purposes. Towards this goal, phase-change oxides, including ferroelectrics, ferromagnets and related materials, could reproduce sources, logic units and memories used in current and future computing schemes.
氧化物提供的最具创新性的可能性之一是将热流用于计算目的。为了实现这一目标,相变氧化物,包括铁电体、铁磁体和相关材料,可以重现当前和未来计算方案中使用的源代码、逻辑单元和存储器。
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引用次数: 0
Liquid-metal-based magnetic fluids 液态金属磁性流体
IF 83.5 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-15 DOI: 10.1038/s41578-024-00679-w
Wentao Xiang, Yongyu Lu, Hongzhang Wang, Xuyang Sun, Sen Chen, Zhizhu He, Jing Liu
Magnetic fluids, suspensions of magnetic particles in carrier liquids like water, oil or organic solvents, combine magnetic properties with fluidity to achieve features such as rapid magnetic response, reversible viscosity, and tunable thermal and optical properties. However, these carriers tend to have low densities and boiling points, affecting the suspension stability and working temperature range of magnetic fluids. Using liquid metals — which have high densities, boiling points and chemical stability in addition to excellent conductivity — as the carrier liquid can not only overcome these issues but also make the resulting liquid-metal-based magnetic fluids (LMMFs) highly conductive, substantially expanding the functions of magnetic fluids. Furthermore, LMMFs behave in complex yet versatile ways owing to synergies between the electrical conduction of the liquid metal and the magnetism of the suspended particles. This Review provides a comprehensive overview of LMMFs, beginning with their fabrication methods and an interpretation of their suspension stability. We summarize the properties and applications of LMMFs, highlighting their superiority over traditional magnetic fluids. Finally, we discuss the challenges and prospects of these materials. Liquid-metal-based magnetic fluids exhibit rich electromagnetic, thermofluidic behaviours, leading to emerging applications in soft robotics, stretchable electronics, energy management and biomedical technology. This Review covers the fabrication, properties and applications of liquid-metal-based magnetic fluids, highlighting their superiority over traditional magnetic fluids.
磁性流体是磁性颗粒在水、油或有机溶剂等载液中的悬浮液,它将磁性和流动性结合在一起,具有快速磁响应、可逆粘度、可调热和光学特性等特点。然而,这些载液的密度和沸点往往较低,影响了磁性流体的悬浮稳定性和工作温度范围。使用液态金属作为载液,不仅能克服这些问题,还能使液态金属基磁性流体(LMMF)具有高导电性,从而大大扩展了磁性流体的功能。此外,由于液态金属的导电性和悬浮颗粒的磁性之间的协同作用,液态金属基磁性流体的行为复杂而多变。本综述全面概述了 LMMFs,首先介绍了其制造方法并解释了其悬浮稳定性。我们总结了 LMMF 的特性和应用,强调了其优于传统磁性流体的特性。最后,我们讨论了这些材料面临的挑战和前景。
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引用次数: 0
AV3Sb5 kagome superconductors AV3Sb5 神户超导体
IF 83.5 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-10 DOI: 10.1038/s41578-024-00677-y
Stephen D. Wilson, Brenden R. Ortiz
The recent discovery of the AV3Sb5 (A = K, Rb, Cs) kagome superconductors launched a growing field of research investigating the interplay between superconductivity and charge-density wave order in kagome metals. Specifically, the AV3Sb5 family of materials naturally exhibits a Fermi level close to the Van Hove singularities associated with the saddle points formed from the prototypical kagome band structure. The charge-density wave and superconducting states that form within the kagome networks of these compounds exhibit a number of anomalous properties reminiscent of theoretical predictions of exotic states in kagome metals tuned close to their Van Hove fillings. In this Review, we discuss the key structural and electronic features of AV3Sb5 compounds and survey the status of investigations of their unconventional electronic phase transitions. The family of AV3Sb5 kagome superconductors provides a fascinating platform for the investigation of the interplay between superconductivity and charge-density wave order. This Review discusses the properties of the anomalous charge-density wave and superconducting states observed in these materials and surveys future directions in the study of these and related kagome metals.
最近发现的 AV3Sb5(A = K、Rb、Cs)卡哥美超导体,开启了研究卡哥美金属中超导性与电荷密度波秩序之间相互作用的一个不断增长的研究领域。具体地说,AV3Sb5 系列材料的费米级自然地接近与原型可果美的带状结构形成的鞍点相关的范霍夫奇点。在这些化合物的卡戈枚网络中形成的电荷密度波和超导态表现出许多反常特性,让人联想到理论预测的卡戈枚金属中接近范霍夫填充的奇异态。在这篇综述中,我们将讨论 AV3Sb5 化合物的主要结构和电子特征,并对其非常规电子相变的研究现状进行调查。
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引用次数: 0
High-throughput characterization is key to report reliable organic thin-film transistor performance 高通量表征是报告可靠的有机薄膜晶体管性能的关键
IF 83.5 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-08 DOI: 10.1038/s41578-024-00689-8
Joseph Manion, Benoît H. Lessard
Developing circuits for flexible and stretchable devices demands not only high performance but also reliable and predictable components, such as organic thin-film transistors. High-throughput characterization is required to build reliable structure–property relationships, which are critical for the commercialization of new materials.
为柔性和可拉伸设备开发电路不仅需要高性能,还需要可靠和可预测的元件,如有机薄膜晶体管。建立可靠的结构-性能关系需要高通量表征,这对新材料的商业化至关重要。
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引用次数: 0
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Nature Reviews Materials
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