Neuroscience最新文献_第8页

On the origin of variance along the uncontrolled manifold: Its effects on anticipatory and spontaneous changes in performance-stabilizing synergies in force production tasks

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-06 DOI: 10.1016/j.neuroscience.2025.02.009

Valters Abolins , Edgars Bernans , Mark L. Latash

We used the framework of the uncontrolled manifold (UCM) hypothesis to explore the origin of inter-trial variance within the UCM, which by definition does not affect the salient performance variable, during accurate two-finger force production. Specifically, we tested several hypotheses on two main sources of variance within the UCM, variability in the sharing patterns between the fingers across trials and covaried variability in finger forces within individual trials. We also explored effects on unintentional changes in the structure of variance during preparation for a quick force change and during force drift without visual feedback. Fourteen young healthy participants performed two-finger force production trials with feedback on total force only or individual finger forces. In one part, they were instructed to produce a quick force pulse in a self-paced manner. In the other, they tried to keep finger forces unchanged without visual feedback. All manipulations led to significant changes in variance along the UCM, but not the ORT, space orthogonal to the UCM. Namely, the relative variance along the UCM dropped prior to quick force production and was not different from the ORT after the force drift. Changing the initial magnitude of variance along the UCM was reflected in its magnitude during anticipatory synergy adjustments prior to the force pulse and following the unintentional force drift. We interpret the results assuming a hierarchical control with two commands, reciprocal and coactivation. The results support the scheme with two contributing factors to variance along the UCM, likely associated with feed-forward and feedback mechanisms.

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引用次数: 0

The role of left anterior temporal lobe in basic linguistic composition: Evidence from stereo-electroencephalography

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-06 DOI: 10.1016/j.neuroscience.2025.02.012

Zhiqiang Yan , Wenjia Zhang , Qiufeng Dong , Jie Dong , Yingying Huang , Xiaofan Jiang , Hao Yan

Determining the neural bases of basic linguistic composition is central to research on the cognitive neuroscience of language. The left anterior temporal lobe (LATL) is widely reported during linguistic composition of visual stimuli in magnetoencephalography (MEG) studies. However, this effect is less reported during the linguistic composition of auditory stimuli in intracranial electroencephalography (iEEG) studies. To further test this discrepancy, we directly examined the composition effect in LATL by combining the iEEG technique with visual stimuli. Participants were asked to read minimal two-word phrases in the composition condition and read words preceded by pound signs in the noncomposition condition. The results showed that high-gamma power in the LATL was higher in the composition condition compared to the noncomposition condition. These results provide more substantial evidence for the role of LATL in basic linguistic composition (at least in visual modality) and highlight the potential role of stimuli modality (visual vs. auditory) in the phrasal composition effect in LATL.

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引用次数: 0

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-06 DOI: 10.1016/j.neuroscience.2025.02.007

Spandana Rajendra Kopalli , Tapan Behl , Ashishkumar Kyada , M.M. Rekha , Mayank Kundlas , Pooja Rani , Deepak Nathiya , K. Satyam Naidu , Monica Gulati , Manish Bhise , Priyanka Gupta , Pranay Wal , Mohammad Fareed , Seema Ramniwas , Sushruta Koppula , Amin Gasmi

Flavonoids are a broad family of polyphenolic chemicals that are present in a wide variety of fruits, vegetables, and medicinal plants. Because of their neuroprotective qualities, flavonoids have attracted a lot of interest. The potential of flavonoids to control synaptic plasticity—a crucial process underlying memory, learning, and cognitive function—is becoming more and more clear. Dysregulation of synaptic plasticity is a feature of neurodegenerative diseases such as amyotrophic lateral sclerosis (0.4 %), Parkinson’s (1–2 %), Alzheimer’s (5–7 %), and Huntington’s ((0.2 %)). This review discusses the molecular mechanisms via which flavonoids influence synaptic plasticity as well as their therapeutic potential in neurodegenerative diseases. Flavonoids modulate key signaling pathways such as MAPK/ERK and PI3K/Akt/mTOR to support neuroprotection, synaptic plasticity, and neuronal health, while also influencing neurotrophic factors (BDNF, NGF) and their receptors (TrkB, TrkA). They regulate neurotransmitter receptors like GABA, AMPA, and NMDA to balance excitatory and inhibitory transmission, and exert antioxidant effects via the Nrf2-ARE pathway and anti-inflammatory actions by inhibiting NF-κB signaling, highlighting their potential for treating neurodegenerative diseases. These varied reactions support the preservation of synapse function and neuronal integrity in the face of neurodegenerative insults. Flavonoids can reduce the symptoms of neurodegeneration, prevent synaptic loss, and enhance cognitive function, according to experimental studies. However, there are still obstacles to using these findings in clinical settings, such as limited bioavailability and the need for consistent dose. The focus of future research should be on improving flavonoid delivery systems and combining them with conventional medications.

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引用次数: 0

Central corticotropin releasing hormone receptor 2 may participate in sex differential regulation of cold-evoked eating behavior 中枢促肾上腺皮质激素释放激素受体2可能参与冷诱发进食行为的性别差异调节。

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-06 DOI: 10.1016/j.neuroscience.2024.12.053

Ying Zhou , Shuqing Zhu , Shangwu Ye , Ziyuan Ye , Wenxi Chen , Jieshan Li , Gang Shu , Songbo Wang , Canjun Zhu , Ruifan Wu , Qingyan Jiang , Lina Wang

Corticotropin-releasing factor (CRF) is an important stress hormone, and because of the different distributions and functions of its receptors, CRF has various effects on the stress response of animals. CRF receptor 2 (CRFR2) is a functional receptor of CRF that may be related to appetite regulation and sex differences. In this study, male and female C57BL/6 mice were exposed to an ambient temperature of 4 °C, and feed intake were determined. Consequently, neuronal excitability, as well as the expression of CRFR2 and related genes in the brain were determined. As a result, 1) there were only significant changes in 2 h feed intake and rectal temperature in males; 2) neuronal excitability was elevated in the paraventricular thalamus (PVT) and paraventricular hypothalamic nucleus (PVH) brain regions of both male and female mice; 3) serum corticosterone and the expression of corticosterone receptors in the PVH were elevated in males but not in females; 4) the activation of the CRFR2 signal in the PVT and PVH brain regions differed by sex: the expression of CRFR2 was upregulated in male mice, and the phosphorylation of protein kinase B (AKT) and cAMP-response element binding protein (CREB) was significantly reduced; and 5) the cold-evoked eating behavior of male mice was abolished when CRFR2 in the PVT was knocked down. In summary, we conclude that male mice are more sensitive to cold stress than are female mice. The CRFR2/AKT/CREB signaling pathway in the PVT and PVH may mediate sex differences in the eating behavior of cold-exposed mice.

促肾上腺皮质激素释放因子（CRF）是一种重要的应激激素，由于其受体的分布和功能不同，CRF对动物的应激反应有不同的影响。CRF受体2 （CRFR2）是CRF的功能性受体，可能与食欲调节和性别差异有关。本研究将雄性和雌性C57BL/6小鼠置于4 °C的环境温度下，测定采食量。因此，神经元的兴奋性，以及大脑中CRFR2和相关基因的表达被确定。结果表明：1)雄鱼采食量2 h和直肠温度只有显著变化；2)雌雄小鼠室旁丘脑（PVT）和室旁下丘脑核（PVH）脑区神经元兴奋性升高；3)男性血清皮质酮及PVH皮质酮受体表达升高，女性无升高；4) CRFR2信号在PVT和PVH脑区的激活存在性别差异：雄性小鼠CRFR2表达上调，蛋白激酶B （AKT）和camp反应元件结合蛋白（CREB）磷酸化显著降低；5)当PVT中的CRFR2被敲除时，雄性小鼠的冷诱发进食行为被消除。综上所述，我们得出结论，雄性小鼠比雌性小鼠对冷应激更敏感。PVT和PVH中的CRFR2/AKT/CREB信号通路可能介导冷暴露小鼠饮食行为的性别差异。

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引用次数: 0

NRG1-ErbB4 signaling in the cerebrospinal fluid-contacting nucleus regulates thermal pain in mice 脑脊液接触核NRG1-ErbB4信号通路调节小鼠热痛。

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-06 DOI: 10.1016/j.neuroscience.2024.12.052

Yuhan Ding , Yao Yan , Wei Song , Ying Li , Jing Zhao , Bin Gui , Yijun Zhang , Licai Zhang

The cerebrospinal fluid-contacting nucleus(CSF-contacting nucleus) is a pair of unique nuclei in the brain parenchyma which has long been demonstrated to play an important role in pain signal processing. However, the mechanisms by which the CSF-contacting nucleus intervenes in pain is unclear. The NRG1-ErbB4 signaling plays an important role in the nervous system and has been shown to be involved in the regulation of pain. Whether there is an involvement of NRG1-ErbB4 signaling in the regulation of pain in the CSF-contacting nucleus is currently unknown. Here, our works showed that c-Fos expression in the CSF-contacting nucleus was increased in response to incisional pain. The activation of the CSF-contacting nucleus by chemogenetics could induce thermal hyperalgesia in naive mice without effecting the pain in mice suffering from incision pain. The inhibition of the CSF-contacting nucleus alleviated incision pain, but had no effect on the pain response in naive mice. With immunofluorescence staining and Western blot, the NRG1-ErbB4 signaling in the CSF-contacting nucleus showed upregulated during the acute pain phase. And, activating NRG1-ErbB4 signaling in the CSF-contacting nucleus specifically by intracranial injection of drugs, the naïve mice displayed thermal hyperalgesia while inhibiting this signaling by intracranial injection could reverse the hyperalgesia caused by CSF-contacting nucleus activation, and execute an analgesic effect during the painful phase in mice. Our study suggested that the CSF-contacting nucleus plays a regulatory role in thermal pain in mice via NRG1-ErbB4 signaling.

脑脊液接触核（csf -contact nucleus, csf -contact nucleus）是脑实质中一对独特的核，长期以来被证明在疼痛信号处理中起重要作用。然而，接触csf核在术后疼痛中的作用尚不清楚。在这里，我们的研究表明，c-Fos在与csf接触的核中的表达随着切口疼痛的增加而增加。化学遗传学方法激活接触csf的核可诱导小鼠热痛觉过敏，但不影响切口痛小鼠的疼痛。对接触csf核的抑制可减轻小鼠切口疼痛，但对基底痛无影响。此外，通过免疫荧光染色和Western blot技术发现，在急性疼痛期，接触csf核中的NRG1-ErbB4信号表达上调。通过特异性激活接触csf核内的NRG1-ErbB4信号通路，naïve小鼠表现出热痛觉过敏，抑制该信号通路可逆转接触csf核激活引起的痛觉过敏，并在小鼠疼痛期发挥镇痛作用。我们的研究表明，接触csf的核通过NRG1-ErbB4信号在小鼠热痛中起调节作用。

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引用次数: 0

Disrupted topology of the functional white matter connectome in thyroid-associated ophthalmopathy

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-05 DOI: 10.1016/j.neuroscience.2025.02.011

Xiao-Tong Li , Yu-Lin Zhong , Xin Shu , Jia-Qi Chen , Di Zhu , Xin Huang

Background

This study aims to investigate the changes in the topological organization of WM functional connectivity in individuals with TAO, providing a novel and insightful perspective on the functional disruptions that characterize this condition.

Methods

This study utilized resting-state functional Magnetic Resonance Imaging (rs-fMRI) to capture blood-oxygen-level-dependent (BOLD) signals and T1-weighted images from patients with TAO and healthy control subjects. Group-level masks for white matter were created to extract WM-related BOLD signals, facilitating the construction of a functional white matter network. Graph theory analysis was subsequently conducted to evaluate global metrics, nodal metrics, and modularity, alongside network-based analysis. Finally, support vector machines (SVM) were employed for classification.

Results

A functional white matter network comprising 128 nodes and their respective connections was identified. The graph theory analysis revealed significant differences primarily in the sigma characteristic of the global small-world metrics, with a notable decrease in betweenness centrality observed in the splenium of the corpus callosum. Modularity analysis indicated significant intra-module variations in modules 03 and 05, while strong inter-module connections were observed between modules 01 and 03, as well as between modules 02 and 04. Furthermore, network-based statistics (NBS) highlighted 13 networks that exhibited significant alterations in the TAO group compared to healthy controls, underscoring the potential impact of TAO on the organization of white matter networks.

Conclusion

In our study, we found that patients with TAO exhibited abnormalities in the white matter functional network regarding small-world metrics and modularity, which are related to visual and cognitive functions.

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引用次数: 0

Longitudinal observation of radiation-induced cognitive impairment and emotional dysfunction combined with radiation-induced brain injury: Based on animal model and clinical cohort.

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-05 DOI: 10.1016/j.neuroscience.2025.02.010

Ruiqi Xue, Kejia Liu, Xia Hu, Xueying Ma, Shaojian Li, Zhenhong Deng, Ke Zhong, Jingwen Yang, Xiaoqiu Zhu, Sheng Liu, Zhongshan Shi, Meijuan Zhou, Yamei Tang

Background: Radiation-induced cognitive impairment (RICI) and emotional disorder (RIED) are comorbidity which seriously affect the quality of life in radiation-induced brain injury (RIBI) patients.

Purpose: Longitudinal observation on occurrence and development process of RICI and RIED was made in RIBI animal model and RIBI clinical cohort after IMRT.

Methods: RIBI mice and sham control were subjected to three cycles of behavior tests for cognitive and emotional function at post-irradiation 1w, 5w, 9w which corresponded with early, middle and late stage after IMRT. And 139 patients who underwent IMRT after NPC and firstly diagnosed with radiation-induced brain injury were enrolled. Pre-treatment and follow-up neuropsychological assessment of cognition, anxiety and depression were completed.

Results: Compared with control, significant decline in working memory, object recognition memory and social memory was observed in RIBI mice at post-irradiation 5w (middle stage, p < 0.001, p < 0.05 and 0.0781) and post-irradiation 9w (late stage, all p < 0.01). From longitudinal observations, memory impairment mostly occurred at middle stage (both p < 0.05) and maintained to late stage. Anxiety-like behaviors were only observed at post-irradiation 9w (late stage, all p < 0.05). In the clinical cohort, RICI had parallel tendency of cumulative curve and close median onset compared with RIBI. RICI intensively occurred in post-IMRT 2-6 years and progressively deteriorated to post-IMRT > 6 years while RIED occurred and gradually increased at post-IMRT > 6 years. During two-year follow-up visits, half of patients with RICI combined with RIBI benefited from conventional treatment to obtain stable or improved cognition, while the other half of patients had no response or cognition aggravation.

Conclusions: RICI intensively occurred in post-irradiation middle stage and progressed to late stage while RIED occurred mostly in late stage in RIBI. Consistency of RICI and RIED development process was observed.

{"title":"Longitudinal observation of radiation-induced cognitive impairment and emotional dysfunction combined with radiation-induced brain injury: Based on animal model and clinical cohort.","authors":"Ruiqi Xue, Kejia Liu, Xia Hu, Xueying Ma, Shaojian Li, Zhenhong Deng, Ke Zhong, Jingwen Yang, Xiaoqiu Zhu, Sheng Liu, Zhongshan Shi, Meijuan Zhou, Yamei Tang","doi":"10.1016/j.neuroscience.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.02.010","url":null,"abstract":"<p><strong>Background: </strong>Radiation-induced cognitive impairment (RICI) and emotional disorder (RIED) are comorbidity which seriously affect the quality of life in radiation-induced brain injury (RIBI) patients.</p><p><strong>Purpose: </strong>Longitudinal observation on occurrence and development process of RICI and RIED was made in RIBI animal model and RIBI clinical cohort after IMRT.</p><p><strong>Methods: </strong>RIBI mice and sham control were subjected to three cycles of behavior tests for cognitive and emotional function at post-irradiation 1w, 5w, 9w which corresponded with early, middle and late stage after IMRT. And 139 patients who underwent IMRT after NPC and firstly diagnosed with radiation-induced brain injury were enrolled. Pre-treatment and follow-up neuropsychological assessment of cognition, anxiety and depression were completed.</p><p><strong>Results: </strong>Compared with control, significant decline in working memory, object recognition memory and social memory was observed in RIBI mice at post-irradiation 5w (middle stage, p < 0.001, p < 0.05 and 0.0781) and post-irradiation 9w (late stage, all p < 0.01). From longitudinal observations, memory impairment mostly occurred at middle stage (both p < 0.05) and maintained to late stage. Anxiety-like behaviors were only observed at post-irradiation 9w (late stage, all p < 0.05). In the clinical cohort, RICI had parallel tendency of cumulative curve and close median onset compared with RIBI. RICI intensively occurred in post-IMRT 2-6 years and progressively deteriorated to post-IMRT > 6 years while RIED occurred and gradually increased at post-IMRT > 6 years. During two-year follow-up visits, half of patients with RICI combined with RIBI benefited from conventional treatment to obtain stable or improved cognition, while the other half of patients had no response or cognition aggravation.</p><p><strong>Conclusions: </strong>RICI intensively occurred in post-irradiation middle stage and progressed to late stage while RIED occurred mostly in late stage in RIBI. Consistency of RICI and RIED development process was observed.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-04 DOI: 10.1016/j.neuroscience.2025.02.008

LS Morris , J.M. Beltrán , JW Murrough , C Morel

Depressive disorders, including major depressive disorder (MDD), represent one of the most prevalent set of disorders worldwide. MDD is characterized by a range of cognitive, behavioral, and neurobiological changes that contribute to the vast array of symptom profiles that make this disorder particularly difficult to treat. A multitude of established evidence suggests a role for the dopamine system, stemming in part from the ventral tegmental area (VTA), in mediating symptoms and behavioral changes that underlie depression. Developments in cutting-edge technologies in pre-clinical models of depressive phenotypes, such as retrograde tracing, electrophysiological recordings, immunohistochemistry, and molecular profiling, have allowed a deeper characterization of singular VTA neuron molecular, physiological, and projection properties. These developments have highlighted that the VTA is not a homogenous cell population but instead comprises vast cellular diversity that underscores its modular role across various functions related to reward processing, aversion, salience processing, learning and motivation. In this review, we begin by introducing the various cell types and brain regions that comprise the VTA circuitry. Then, we introduce the role of the VTA in reward processing as it compares to aversion processing. Next, we characterize distinct neural pathways within the VTA circuitry to understand the effects of chronic social and non-social stress and tie together how these neurobiological changes manifest into specific behavioral phenotypes. Finally, we relate these preclinical findings to clinical findings to parse the heterogeneity of depressive phenotypes and explain the efficacy of recent novel pharmacological interventions that may target the VTA in MDD.

{"title":"Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders","authors":"LS Morris , J.M. Beltrán , JW Murrough , C Morel","doi":"10.1016/j.neuroscience.2025.02.008","DOIUrl":"10.1016/j.neuroscience.2025.02.008","url":null,"abstract":"<div><div>Depressive disorders, including major depressive disorder (MDD), represent one of the most prevalent set of disorders worldwide. MDD is characterized by a range of cognitive, behavioral, and neurobiological changes that contribute to the vast array of symptom profiles that make this disorder particularly difficult to treat. A multitude of established evidence suggests a role for the dopamine system, stemming in part from the ventral tegmental area (VTA), in mediating symptoms and behavioral changes that underlie depression. Developments in cutting-edge technologies in pre-clinical models of depressive phenotypes, such as retrograde tracing, electrophysiological recordings, immunohistochemistry, and molecular profiling, have allowed a deeper characterization of singular VTA neuron molecular, physiological, and projection properties<em>.</em> These developments have highlighted that the VTA is not a homogenous cell population but instead comprises vast cellular diversity that underscores its modular role across various functions related to reward processing, aversion, salience processing, learning and motivation. In this review, we begin by introducing the various cell types and brain regions that comprise the VTA circuitry. Then, we introduce the role of the VTA in reward processing as it compares to aversion processing. Next, we characterize distinct neural pathways within the VTA circuitry to understand the effects of chronic social and non-social stress and tie together how these neurobiological changes manifest into specific behavioral phenotypes. Finally, we relate these preclinical findings to clinical findings to parse the heterogeneity of depressive phenotypes and explain the efficacy of recent novel pharmacological interventions that may target the VTA in MDD.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"569 ","pages":"Pages 248-266"},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidimensional-based exploration of gut microbial and metabolite differences in patients with recurrent stroke.

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-04 DOI: 10.1016/j.neuroscience.2025.02.004

Zongwei Fang, Sijie Chang, Peiguang Niu, Chunhua Wang, Jinhua Zhang

Objectives: The purpose of this study was to examine variations in gut microbes and their metabolites between patients with original and recurrent stroke, providing insights and justification for the diagnosis and prevention of ischemic stroke progression from the perspective of the gut microbiota-metabolite-brain axis.

Methods: In this study, fecal samples were collected from 95 patients with Original stroke (Os) and 39 patients with Recurrent stroke (Rs) to assess differences in gut microbiota between two groups. Then LC-MS non-targeted metabolomics was used to screen out the different metabolites and to reveal the physiological changes related to the progression of ischemic stroke.

Results: Beta diversity analysis revealed significant differences in community composition between two groups. Compared with Os patients, 26 genera were dysregulated in Rs patients. For example, Prevotella, Lachnospiraceae_UCG-010, Holdemanella, and Coprococcus were significantly depleted in the Rs group. Correlation analysis showed that the risk of stroke recurrence was negatively correlated with Lachnospiraceae_UCG-010. A total of 38 differential metabolites were identified in both groups. In Rs group, 8 metabolites were up-regulated, including carbohydrates and terpene lactones, and 30 metabolites were down-regulated, including sesquiterpenes, triterpenes, and fatty acids and their couplings. These metabolites are significantly enriched in the pathways of arachidonic acid metabolism, betaine biosynthesis, and linoleic acid metabolism.

Conclusions: Compared with the Os, Rs was mainly characterized by severe destruction of anaerobic bacteria and significant depletion of SCFAs-producing bacteria. In addition, the related compounds involved in arachidonic acid metabolism and linoleic acid metabolism pathway may be biomarkers related to ischemic stroke progression.

{"title":"Multidimensional-based exploration of gut microbial and metabolite differences in patients with recurrent stroke.","authors":"Zongwei Fang, Sijie Chang, Peiguang Niu, Chunhua Wang, Jinhua Zhang","doi":"10.1016/j.neuroscience.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.neuroscience.2025.02.004","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to examine variations in gut microbes and their metabolites between patients with original and recurrent stroke, providing insights and justification for the diagnosis and prevention of ischemic stroke progression from the perspective of the gut microbiota-metabolite-brain axis.</p><p><strong>Methods: </strong>In this study, fecal samples were collected from 95 patients with Original stroke (Os) and 39 patients with Recurrent stroke (Rs) to assess differences in gut microbiota between two groups. Then LC-MS non-targeted metabolomics was used to screen out the different metabolites and to reveal the physiological changes related to the progression of ischemic stroke.</p><p><strong>Results: </strong>Beta diversity analysis revealed significant differences in community composition between two groups. Compared with Os patients, 26 genera were dysregulated in Rs patients. For example, Prevotella, Lachnospiraceae_UCG-010, Holdemanella, and Coprococcus were significantly depleted in the Rs group. Correlation analysis showed that the risk of stroke recurrence was negatively correlated with Lachnospiraceae_UCG-010. A total of 38 differential metabolites were identified in both groups. In Rs group, 8 metabolites were up-regulated, including carbohydrates and terpene lactones, and 30 metabolites were down-regulated, including sesquiterpenes, triterpenes, and fatty acids and their couplings. These metabolites are significantly enriched in the pathways of arachidonic acid metabolism, betaine biosynthesis, and linoleic acid metabolism.</p><p><strong>Conclusions: </strong>Compared with the Os, Rs was mainly characterized by severe destruction of anaerobic bacteria and significant depletion of SCFAs-producing bacteria. In addition, the related compounds involved in arachidonic acid metabolism and linoleic acid metabolism pathway may be biomarkers related to ischemic stroke progression.</p>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and circadian rhythm activity alterations during adolescence in a mouse model of neonatal fentanyl withdrawal syndrome

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience

Pub Date : 2025-02-04 DOI: 10.1016/j.neuroscience.2025.01.064

Benjamin R. Williams , Mackenzie C. Gamble , Navsharan Singh , Camron D. Bryant , Beth A. Logan , Ryan W. Logan

Fentanyl, a highly potent synthetic opioid, is a major contributor to the ongoing opioid epidemic. During adulthood, fentanyl is known to induce pronounced sleep and circadian disturbances during use and withdrawal. Children exposed to opioids in utero are likely to develop neonatal opioid withdrawal syndrome, and display sleep disturbances after birth. However, it is currently unknown how neonatal opioid withdrawal from fentanyl impacts sleep and circadian rhythms in mice later in life. To model neonatal opioid withdrawal syndrome, mice were treated with fentanyl from postnatal days 1 through 14, analogous to the third trimester of human gestation. After weaning, fentanyl and saline treated mice underwent non-invasive sleep and circadian rhythm monitoring during adolescence postnatal days 23 through 30. Neonatal fentanyl exposure led to an increase in the percent time spent in rapid eye movement sleep across days. Thus, neonatal fentanyl exposure leads to altered sleep-wake states during adolescence in mice.

{"title":"Sleep and circadian rhythm activity alterations during adolescence in a mouse model of neonatal fentanyl withdrawal syndrome","authors":"Benjamin R. Williams , Mackenzie C. Gamble , Navsharan Singh , Camron D. Bryant , Beth A. Logan , Ryan W. Logan","doi":"10.1016/j.neuroscience.2025.01.064","DOIUrl":"10.1016/j.neuroscience.2025.01.064","url":null,"abstract":"<div><div>Fentanyl, a highly potent synthetic opioid, is a major contributor to the ongoing opioid epidemic. During adulthood, fentanyl is known to induce pronounced sleep and circadian disturbances during use and withdrawal. Children exposed to opioids <em>in utero</em> are likely to develop neonatal opioid withdrawal syndrome, and display sleep disturbances after birth. However, it is currently unknown how neonatal opioid withdrawal from fentanyl impacts sleep and circadian rhythms in mice later in life. To model neonatal opioid withdrawal syndrome, mice were treated with fentanyl from postnatal days 1 through 14, analogous to the third trimester of human gestation. After weaning, fentanyl and saline treated mice underwent non-invasive sleep and circadian rhythm monitoring during adolescence postnatal days 23 through 30. Neonatal fentanyl exposure led to an increase in the percent time spent in rapid eye movement sleep across days. Thus<strong>,</strong> neonatal fentanyl exposure leads to altered sleep-wake states during adolescence in mice.</div></div>","PeriodicalId":19142,"journal":{"name":"Neuroscience","volume":"569 ","pages":"Pages 85-91"},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0