Nutrition & Metabolism最新文献

Background: Dietary carotenoids may have independent positive impacts on a range of health-related outcomes such as obesity. The purpose of this study was to examine the associations between individual and total dietary carotenoids and the likelihood of being overweight or obese.

Methods: Dietary intakes of 4202 participants of the PERSIAN cohort study were investigated by a 237-item FFQ, and carotenoid intake was determined using the USDA food databases. Models of logistic regression were applied to assess the association between obesity and overweight and dietary intake of carotenoids after adjusting for confounders.

Results: Higher total carotenoid intake was associated with reduced risk of overweight (energy-adjusted OR: 0.647, 95% CI: 0.429-0.975, P = 0.037) and obesity (energy-adjusted OR: 0.395, 95% CI: 0.244-0.640, P < 0.001). Specific individual carotenoids, including β-carotene (OR: 0.510, 95% CI: 0.356-0.731, P < 0.001), lutein/zeaxanthin (OR: 0.479, 95% CI: 0.331-0.692, P < 0.001), and phytoene (OR = 0.450, 95% CI = 0.306-0.661, P < 0.001) exhibited stronger inverse associations compared to lycopene and astaxanthin.

Conclusion: Diets rich in specific carotenoids, particularly β-carotene, lutein, and phytoene, may reduce the risk of both overweight and obesity. Future research ought to examine the mechanisms behind the relations of carotenoids with public health issues.

Background: The quantitative effects of integrating healthy lifestyles with depression on mortality remain unclear.

Methods: A total of 19, 528 individuals from NHANES and 75, 785 participants from the UK Biobank were analyzed. The associations between combined healthy lifestyle and depression with mortality were evaluated using Cox proportional hazards regression and Kaplan-Meier survival curves.

Results: There were 855 or 2,286 instances of all-cause death and 249 or 405 instances of cardiovascular death, respectively. Participants exhibiting healthier lifestyle choices or better depression status had a reduced risk of death. Moreover, individuals adhering to a favorable lifestyle and concurrently staying mentally healthy had a reduced risk of all-cause and cardiovascular death compared to their counterparts (adjusted-HR: 0.37, 95% CI 0.27 to 0.51 for all-cause death, P < 0.001; adjusted-HR: 0.42, 95% CI 0.23 to 0.77, P = 0.027 for cardiovascular death in the NHANES database; adjusted-HR: 0.33, 95% CI 0.27 to 0.40 for all-cause death, P < 0.001; adjusted-HR: 0.40, 95% CI 0.24 to 0.67, P = 0.002 for cardiovascular death in the UK Biobank). Additionally, the joint association of lifestyle and depression categories on cardiovascular mortality was modified by metabolic syndrome.

Conclusions: Subjects adhering to a favorable lifestyle and concurrently staying mentally healthy had a reduced risk of all-cause and cardiovascular death compared to their counterparts. This joint association of lifestyle and depression on cardiovascular mortality was modified by metabolic syndrome.

Background: Diet is a determinant of metabolic health, partly through its effects on the gut microbiome, which influences nutrient metabolism, inflammation, and energy balance. We investigated the mediating role of gut microbiome features in the association between dietary quality and metabolic risk.

Methods: In this cross-sectional study, we included 269 adults aged 25-76 years with heterogeneous metabolic profiles, BMI ranging from 17.5 to 47.6 kg/m², and fasting glucose levels between 5.6 and 6.9 mmol/L. Dietary quality was assessed using the Healthy Eating Index (HEI-MON), the Planetary Health Diet Index (PHEI-MON), and the alternate Mediterranean Diet Score (aMED), derived from food-frequency questionnaires and three-day food records. Metabolic risk was quantified using a continuous metabolic syndrome score (cMetS) incorporating waist circumference, mean arterial pressure, HDL cholesterol, triglycerides, and fasting glucose. Microbiome composition (16 S rRNA gene sequencing) and predicted SCFA pathways were analyzed using adjusted multiple linear regression, PERMANOVA, and differential abundance analysis. Mediation analyses examined microbial features as potential mediators of the association between diet and metabolic risk.

Results: Higher HEI-MON, PHEI-MON, and aMED were associated with lower cMetS (q < 0.01). Christensenellaceae R7 group and Ruminococcaceae NK4A214 group were enriched with higher dietary quality and lower cMetS (q < 0.1), whereas Lachnoclostridium were associated with lower diet quality and higher cMetS (q < 0.1). The Enterotype Dysbiosis Score (EDS) correlated inversely with dietary quality (PHEI-MON q = 0.04) and positively with cMetS (q = 0.04). Butyrate-synthesis pathways were more abundant in individuals with higher dietary quality (q < 0.05) and inversely associated with cMetS (q < 0.05). Mediation analysis indicated that the Ruminococcaceae NK4A214 group, the Christensenellaceae R7 group, and Lachnoclostridium accounted for up to 16% of the association between diet and metabolic risk.

Conclusion: Better dietary quality is associated with lower metabolic risk and positive gut microbiome signatures across taxonomic, functional, and stability-related aspects. Certain taxa statistically mediated these associations, highlighting gut microbiome features that may contribute to observed links between dietary patterns and metabolic health.

Background: Helicobacter pylori infection and oxidative stress are most common factors for development of gastric ulcers which is consider to be a most common gastrointestinal disorder. The main objective of this research was to evaluate the effects of avocado seeds aqueous extract as an adjunct to conventional ulcer treatment.

Methods: A randomized controlled trial was conducted with the participation of 99 patients diagnosed with gastric ulcers. Participants were randomly divided to a control group receiving standard medication and interventional group receiving the same treatment with avocado seeds aqueous extract. Screening and follow-up assessments assessment was performed by barium meal tests, radiological imaging, and serological markers, including H. pylori IgG and IgM (ELISA).

Results: Patients in the intervention group showed significant improvements in ulcer morphology and a marked reduction in H. pylori IgG and IgM levels compared with the control group (p < 0.05). Radiological findings also confirmed better mucosal healing in the supplemented group after 12 weeks of intervention.

Conclusions: Intervention group with avocado seeds aqueous extract showed a positive effect combined with conventional treatment, suggesting its potential as a natural adjunct therapy in management of gastric ulcers.