Understanding the nucleation mechanism in glass is crucial for the development of new glass-ceramic materials. Herein, we report the structure of a commercially important glass-ceramic ZrO2-doped lithium aluminosilicate system during its initial nucleation stage. We conducted an X-ray multiscale analysis, and this analysis was used to observe the structure from the atomic to the nanometer scale by using diffraction, small-angle scattering, absorption, and anomalous scattering techniques. The inherent phase separation between the Zr-rich and Zr-poor regions in the pristine glass was enhanced by thermal treatment without changing the spatial geometry at the nanoscale. Element-specific pair distribution function analysis using anomalous X-ray scattering data showed the formation of a liquid ZrO2-like local structural motif and edge sharing between the ZrOx polyhedra and (Si/Al)O4 tetrahedra during the initial nucleation stage. Furthermore, the local structure of the Zr4+ ions resembled a cubic or tetragonal ZrO2 crystalline phase and formed after 2 h of annealing the pristine glass. Therefore, the Zr-centric periodic structure formed in the early stage of nucleation was potentially the initial crystal nucleus for the Zr-doped lithium aluminosilicate glass-ceramic. This research examines the early changes in the formation of zirconium-doped aluminosilicate glass-ceramic, a material used in many industrial goods. Led by Y. Onodera and Y. Takimoto, the study shows that during the formation process, a liquid-like local structure around a Zr4+ ion (a positively charged particle) and shared structures between ZrOx and (Si/Al)O4 tetrahedra (four-faced geometric shapes) are created. The researchers used various X-ray techniques to perform a detailed structural analysis. This study offers fresh understanding of the structure of formation agents in glasses and could improve our knowledge of the formation process in the early stages of glass-ceramic materials. Future studies could look into how these findings could be used in creating new materials. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. The structure of a commercially important glass-ceramic ZrO2-doped lithium aluminosilicate system during its initial nucleation stage was investigated by an X-ray multiscale analysis which enables us to observe the structure from the atomic to the nanometer scale by using diffraction, small-angle scattering, absorption, and anomalous scattering techniques. The combinatorial approach revealed that the formation of edge sharing between the ZrOx polyhedra and (Si/Al)O4 tetrahedra, and that the Zr-centric periodic structure in which the local structure of the Zr4+ ions resembled a cubic or tetragonal ZrO2 crystalline phase was potentially the initial crystal nucleus for the Zr-doped lithium aluminosilicate glass-ceramic.
了解玻璃中的成核机制对于开发新型玻璃陶瓷材料至关重要。在此，我们报告了一种具有重要商业价值的玻璃陶瓷 ZrO2 掺杂铝硅酸锂体系在其初始成核阶段的结构。我们进行了 X 射线多尺度分析，并利用衍射、小角散射、吸收和反常散射技术观察了从原子到纳米尺度的结构。原始玻璃中富锆区和贫锆区之间的固有相分离通过热处理得到了加强，但并没有改变纳米尺度的空间几何结构。利用反常 X 射线散射数据进行的元素特异对分布函数分析表明，在初始成核阶段形成了类似 ZrO2 的液态局部结构图案，ZrOx 多面体和（Si/Al）O4 四面体之间实现了边缘共享。此外，Zr4+ 离子的局部结构类似于立方或四方 ZrO2 结晶相，并在原始玻璃退火 2 小时后形成。因此，成核初期形成的以 Zr 为中心的周期性结构可能是掺杂 Zr 的锂铝硅酸盐玻璃陶瓷的初始晶核。
{"title":"Formation of a zirconium oxide crystal nucleus in the initial nucleation stage in aluminosilicate glass investigated by X-ray multiscale analysis","authors":"Yohei Onodera, Yasuyuki Takimoto, Hiroyuki Hijiya, Qing Li, Hiroo Tajiri, Toshiaki Ina, Shinji Kohara","doi":"10.1038/s41427-024-00542-y","DOIUrl":"10.1038/s41427-024-00542-y","url":null,"abstract":"Understanding the nucleation mechanism in glass is crucial for the development of new glass-ceramic materials. Herein, we report the structure of a commercially important glass-ceramic ZrO2-doped lithium aluminosilicate system during its initial nucleation stage. We conducted an X-ray multiscale analysis, and this analysis was used to observe the structure from the atomic to the nanometer scale by using diffraction, small-angle scattering, absorption, and anomalous scattering techniques. The inherent phase separation between the Zr-rich and Zr-poor regions in the pristine glass was enhanced by thermal treatment without changing the spatial geometry at the nanoscale. Element-specific pair distribution function analysis using anomalous X-ray scattering data showed the formation of a liquid ZrO2-like local structural motif and edge sharing between the ZrOx polyhedra and (Si/Al)O4 tetrahedra during the initial nucleation stage. Furthermore, the local structure of the Zr4+ ions resembled a cubic or tetragonal ZrO2 crystalline phase and formed after 2 h of annealing the pristine glass. Therefore, the Zr-centric periodic structure formed in the early stage of nucleation was potentially the initial crystal nucleus for the Zr-doped lithium aluminosilicate glass-ceramic. This research examines the early changes in the formation of zirconium-doped aluminosilicate glass-ceramic, a material used in many industrial goods. Led by Y. Onodera and Y. Takimoto, the study shows that during the formation process, a liquid-like local structure around a Zr4+ ion (a positively charged particle) and shared structures between ZrOx and (Si/Al)O4 tetrahedra (four-faced geometric shapes) are created. The researchers used various X-ray techniques to perform a detailed structural analysis. This study offers fresh understanding of the structure of formation agents in glasses and could improve our knowledge of the formation process in the early stages of glass-ceramic materials. Future studies could look into how these findings could be used in creating new materials. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. The structure of a commercially important glass-ceramic ZrO2-doped lithium aluminosilicate system during its initial nucleation stage was investigated by an X-ray multiscale analysis which enables us to observe the structure from the atomic to the nanometer scale by using diffraction, small-angle scattering, absorption, and anomalous scattering techniques. The combinatorial approach revealed that the formation of edge sharing between the ZrOx polyhedra and (Si/Al)O4 tetrahedra, and that the Zr-centric periodic structure in which the local structure of the Zr4+ ions resembled a cubic or tetragonal ZrO2 crystalline phase was potentially the initial crystal nucleus for the Zr-doped lithium aluminosilicate glass-ceramic.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-13"},"PeriodicalIF":8.6,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00542-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1038/s41427-024-00539-7
Shenghui Su, Jiajun Xie, Jian Gao, Shencai Liu, Xieping Dong, Jianwei Li, Zhong Feng Gao, Keyuan Chen, Weilu Liu
Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available materials are functionally limited and often fail to improve outcomes in this patient population. In this study, we developed orthopedic adhesives doped with romosozumab-loaded mesoporous bioactive glass nanoparticles to aid in osteoporotic fracture fixation and restore dysregulated bone homeostasis. These adhesives were designed to promote osteoblast formation while simultaneously inhibiting osteoclastic bone-resorbing activity, thus working synergistically to promote the healing of osteoporotic fractures. Orthopedic adhesives exhibit injectability, reversible adhesiveness, and malleability, enhancing their adaptability to complex clinical scenarios. Furthermore, the release of romosozumab from mesoporous bioactive glass nanoparticles accelerated osteogenesis and inhibited osteoclastogenesis, delaying the bone resorption process. This dual action contributes to the regulation of bone regeneration and remodeling. Notably, our orthopedic adhesive could restore the disrupted bone homeostasis associated with osteoporotic fractures. Schematic diagrams of GORoM adhesive and osteoporotic fractures treatment. A The process of OVX rat model establishment and GORoM adhesive implantation. B Osteoporotic fracture healing was mediated by the osteogenesis promotion and osteoclast inhibition.
{"title":"A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis","authors":"Shenghui Su, Jiajun Xie, Jian Gao, Shencai Liu, Xieping Dong, Jianwei Li, Zhong Feng Gao, Keyuan Chen, Weilu Liu","doi":"10.1038/s41427-024-00539-7","DOIUrl":"10.1038/s41427-024-00539-7","url":null,"abstract":"Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available materials are functionally limited and often fail to improve outcomes in this patient population. In this study, we developed orthopedic adhesives doped with romosozumab-loaded mesoporous bioactive glass nanoparticles to aid in osteoporotic fracture fixation and restore dysregulated bone homeostasis. These adhesives were designed to promote osteoblast formation while simultaneously inhibiting osteoclastic bone-resorbing activity, thus working synergistically to promote the healing of osteoporotic fractures. Orthopedic adhesives exhibit injectability, reversible adhesiveness, and malleability, enhancing their adaptability to complex clinical scenarios. Furthermore, the release of romosozumab from mesoporous bioactive glass nanoparticles accelerated osteogenesis and inhibited osteoclastogenesis, delaying the bone resorption process. This dual action contributes to the regulation of bone regeneration and remodeling. Notably, our orthopedic adhesive could restore the disrupted bone homeostasis associated with osteoporotic fractures. Schematic diagrams of GORoM adhesive and osteoporotic fractures treatment. A The process of OVX rat model establishment and GORoM adhesive implantation. B Osteoporotic fracture healing was mediated by the osteogenesis promotion and osteoclast inhibition.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-17"},"PeriodicalIF":8.6,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00539-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140560857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zinc-ion hybrid supercapacitors (ZHSCs) are attracting significant attention due to their high energies/power densities, safety, and low cost. In this review, recent advances in the development of ZHSCs are summarized. Particular emphasis is placed on state-of-the-art cathodes (including carbon, metal oxides, MXenes, and redox-active polymers), anodes (including Zn-based composites and Zn-free materials) and electrolytes for ZHSCs. Furthermore, the latest research on functional ZHSC devices with miniaturized ZHSCs, fiber-shaped ZHSCs, self-chargeable ZHSCs and self-healing devices is reported. Finally, further developments with ZHSCs are envisaged for future research in this thriving field. This research is emphasized particularly on cathodes (such as carbon, metal oxides, MXenes, and redox-active polymers), anodes (such as Zn-based composite materials and Zn-free materials), electrolytes (organic/ionic liquid electrolytes, WiSs, redox electrolytes, polymer or solid electrolytes) as well as the design of a novel device for ZHSCs.
{"title":"Recent advances in functional materials and devices for Zn-Ion hybrid supercapacitors","authors":"Weijia Fan, Faxing Wang, Xiaosong Xiong, Bingyan Song, Tao Wang, Xinbing Cheng, Zhi Zhu, Jiarui He, Yankai Liu, Yuping Wu","doi":"10.1038/s41427-024-00537-9","DOIUrl":"10.1038/s41427-024-00537-9","url":null,"abstract":"Zinc-ion hybrid supercapacitors (ZHSCs) are attracting significant attention due to their high energies/power densities, safety, and low cost. In this review, recent advances in the development of ZHSCs are summarized. Particular emphasis is placed on state-of-the-art cathodes (including carbon, metal oxides, MXenes, and redox-active polymers), anodes (including Zn-based composites and Zn-free materials) and electrolytes for ZHSCs. Furthermore, the latest research on functional ZHSC devices with miniaturized ZHSCs, fiber-shaped ZHSCs, self-chargeable ZHSCs and self-healing devices is reported. Finally, further developments with ZHSCs are envisaged for future research in this thriving field. This research is emphasized particularly on cathodes (such as carbon, metal oxides, MXenes, and redox-active polymers), anodes (such as Zn-based composite materials and Zn-free materials), electrolytes (organic/ionic liquid electrolytes, WiSs, redox electrolytes, polymer or solid electrolytes) as well as the design of a novel device for ZHSCs.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-20"},"PeriodicalIF":8.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00537-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140560938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, using the Pt/Cr2O3/Pt epitaxial trilayer, we demonstrate the giant voltage modulation of the antiferromagnetic spin reversal and the voltage-induced 180° switching of the Néel vector in maintaining a permanent magnetic field. We obtained a significant modulation efficiency of the switching field, Δμ0HSW/ΔV (Δμ0HSW/ΔE), reaching a maximum of −500 mT/V (−4.80 T nm/V); this value was more than 50 times greater than that of the ferromagnetic-based counterparts. From the temperature dependence of the modulation efficiency, X-ray magnetic circular dichroism measurements and first-principles calculations, we showed that the origin of the giant modulation efficiency relied on the electric field modulation of the net magnetization due to the magnetoelectric effect. From the first-principles calculation and the thickness effect on the offset electric field, we found that the interfacial magnetoelectric effect emerged. Our demonstration reveals the energy-efficient and widely applicable operation of an antiferromagnetic spin based on a mechanism distinct from magnetic anisotropy control. We demonstrate the magnetic-field induced reversal of antiferromagnetic spins and the electric field modulation of the switching field. The modulation efficiency is significantly high, greater than 4 T nm/V, and this giant modulation efficiency is attributed to the magnetoelectric effect of the antiferromagnetic Cr2O3. The magnetoelectric (ME) based mechanism provides a scheme for the energy-efficient, nonvolatile, deterministic 180° switching of the magnetic state in the pure antiferromagnetic (AFM) component. This study represents a great advancement in the AFM-based ME random access memory with ultralow writing power, an inherently fast switching speed and superior robustness to the magnetic state.
{"title":"Giant gate modulation of antiferromagnetic spin reversal by the magnetoelectric effect","authors":"Kakeru Ujimoto, Hiroki Sameshima, Kentaro Toyoki, Takahiro Moriyama, Kohji Nakamura, Yoshinori Kotani, Motohiro Suzuki, Ion Iino, Naomi Kawamura, Ryoichi Nakatani, Yu Shiratsuchi","doi":"10.1038/s41427-024-00541-z","DOIUrl":"10.1038/s41427-024-00541-z","url":null,"abstract":"In this study, using the Pt/Cr2O3/Pt epitaxial trilayer, we demonstrate the giant voltage modulation of the antiferromagnetic spin reversal and the voltage-induced 180° switching of the Néel vector in maintaining a permanent magnetic field. We obtained a significant modulation efficiency of the switching field, Δμ0HSW/ΔV (Δμ0HSW/ΔE), reaching a maximum of −500 mT/V (−4.80 T nm/V); this value was more than 50 times greater than that of the ferromagnetic-based counterparts. From the temperature dependence of the modulation efficiency, X-ray magnetic circular dichroism measurements and first-principles calculations, we showed that the origin of the giant modulation efficiency relied on the electric field modulation of the net magnetization due to the magnetoelectric effect. From the first-principles calculation and the thickness effect on the offset electric field, we found that the interfacial magnetoelectric effect emerged. Our demonstration reveals the energy-efficient and widely applicable operation of an antiferromagnetic spin based on a mechanism distinct from magnetic anisotropy control. We demonstrate the magnetic-field induced reversal of antiferromagnetic spins and the electric field modulation of the switching field. The modulation efficiency is significantly high, greater than 4 T nm/V, and this giant modulation efficiency is attributed to the magnetoelectric effect of the antiferromagnetic Cr2O3. The magnetoelectric (ME) based mechanism provides a scheme for the energy-efficient, nonvolatile, deterministic 180° switching of the magnetic state in the pure antiferromagnetic (AFM) component. This study represents a great advancement in the AFM-based ME random access memory with ultralow writing power, an inherently fast switching speed and superior robustness to the magnetic state.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-11"},"PeriodicalIF":8.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00541-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-29DOI: 10.1038/s41427-024-00536-w
Takamitsu Ishiyama, Koki Nozawa, Takeshi Nishida, Takashi Suemasu, Kaoru Toko
Studying the properties of thermoelectric materials needs substantial effort owing to the interplay of the trade-off relationships among the influential parameters. In view of this issue, artificial intelligence has recently been used to investigate and optimize thermoelectric materials. Here, we used Bayesian optimization to improve the thermoelectric properties of multicomponent III–V materials; this domain warrants comprehensive investigation due to the need to simultaneously control multiple parameters. We designated the figure of merit ZT as the objective function to improve and search for a five-dimensional space comprising the composition of InGaAsSb thin films, dopant concentration, and film-deposition temperatures. After six Bayesian optimization cycles, ZT exhibited an approximately threefold improvement compared to its values obtained in the random initial experimental trials. Additional analysis employing Gaussian process regression elucidated that a high In composition and low substrate temperature were particularly effective at increasing ZT. The optimal substrate temperature (205 °C) demonstrated the potential for depositing InGaAsSb thermoelectric thin films onto plastic substrates. These findings not only promote the development of thermoelectric devices based on III–V semiconductors but also highlight the effectiveness of using Bayesian optimization for multicomponent materials. Bayesian optimization improved the thermoelectric properties of InGaAsSb thin films; this domain warrants comprehensive investigation due to the need to simultaneously control multiple parameters, such as, the composition, dopant concentration, and film-deposition temperatures. After six optimization cycles, the dimensionless figure of merit exhibited an approximately threefold improvement compared to its values obtained in the random initial experimental trials. These findings not only promote the development of thermoelectric devices based on III–V semiconductors but also highlight the effectiveness of using Bayesian optimization for multicomponent materials.
{"title":"Bayesian optimization-driven enhancement of the thermoelectric properties of polycrystalline III-V semiconductor thin films","authors":"Takamitsu Ishiyama, Koki Nozawa, Takeshi Nishida, Takashi Suemasu, Kaoru Toko","doi":"10.1038/s41427-024-00536-w","DOIUrl":"10.1038/s41427-024-00536-w","url":null,"abstract":"Studying the properties of thermoelectric materials needs substantial effort owing to the interplay of the trade-off relationships among the influential parameters. In view of this issue, artificial intelligence has recently been used to investigate and optimize thermoelectric materials. Here, we used Bayesian optimization to improve the thermoelectric properties of multicomponent III–V materials; this domain warrants comprehensive investigation due to the need to simultaneously control multiple parameters. We designated the figure of merit ZT as the objective function to improve and search for a five-dimensional space comprising the composition of InGaAsSb thin films, dopant concentration, and film-deposition temperatures. After six Bayesian optimization cycles, ZT exhibited an approximately threefold improvement compared to its values obtained in the random initial experimental trials. Additional analysis employing Gaussian process regression elucidated that a high In composition and low substrate temperature were particularly effective at increasing ZT. The optimal substrate temperature (205 °C) demonstrated the potential for depositing InGaAsSb thermoelectric thin films onto plastic substrates. These findings not only promote the development of thermoelectric devices based on III–V semiconductors but also highlight the effectiveness of using Bayesian optimization for multicomponent materials. Bayesian optimization improved the thermoelectric properties of InGaAsSb thin films; this domain warrants comprehensive investigation due to the need to simultaneously control multiple parameters, such as, the composition, dopant concentration, and film-deposition temperatures. After six optimization cycles, the dimensionless figure of merit exhibited an approximately threefold improvement compared to its values obtained in the random initial experimental trials. These findings not only promote the development of thermoelectric devices based on III–V semiconductors but also highlight the effectiveness of using Bayesian optimization for multicomponent materials.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-7"},"PeriodicalIF":8.6,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00536-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140323397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.1038/s41427-024-00538-8
Hiroshi Tsukahara, Haodong Huang, Kiyonori Suzuki, Kanta Ono
The mechanism of energy loss due to magnetostriction in soft magnetic materials was analytically formulated, and our experiments validated this formulation. The viscosity of magnetic materials causes the resistive force acting on magnetic domain walls through strain due to magnetostriction, and magnetic energy is eventually dissipated by friction even without eddy currents. This energy loss mechanism explains the frequency dependence of the excess loss observed in the experiments, and the excess loss is dominated by the contribution of magnetostriction when the magnetostriction constant exceeds approximately 20 ppm. The random anisotropy model was extended by considering the effect of local magnetostriction as a correction to the magnetocrystalline anisotropy. The effect of magnetostriction was considerably suppressed by the exchange-averaging effect. The estimated effective random magnetoelastic anisotropy for nanocrystalline α-Fe reached as low as 18.6 J/m3, but this static effect could not explain the high excess loss at high frequencies observed in the experiments. The results of this research could provide new design criteria for high-performance soft magnetic materials based on low magnetostriction to reduce the excess loss. The energy loss mechanism due to magnetostriction was clarified by analytical formulation considering the viscosity of magnetic materials. Effects of magnetostriction have been focused on contributions to magnetic anisotropy. However, our formulation shows that the magnetic anisotropy due to magnetostriction cannot explain excess losses in nanocrystalline soft magnetic materials, and the viscosity causes resistance forces acting on domain wall motions. This viscous resistance dissipates the magnetic energy and generates the energy loss, which has the same frequency dependence as anomalous eddy current loss. The results of this research provide new design criteria for ultra-efficient soft magnetic materials.
{"title":"Formulation of energy loss due to magnetostriction to design ultraefficient soft magnets","authors":"Hiroshi Tsukahara, Haodong Huang, Kiyonori Suzuki, Kanta Ono","doi":"10.1038/s41427-024-00538-8","DOIUrl":"10.1038/s41427-024-00538-8","url":null,"abstract":"The mechanism of energy loss due to magnetostriction in soft magnetic materials was analytically formulated, and our experiments validated this formulation. The viscosity of magnetic materials causes the resistive force acting on magnetic domain walls through strain due to magnetostriction, and magnetic energy is eventually dissipated by friction even without eddy currents. This energy loss mechanism explains the frequency dependence of the excess loss observed in the experiments, and the excess loss is dominated by the contribution of magnetostriction when the magnetostriction constant exceeds approximately 20 ppm. The random anisotropy model was extended by considering the effect of local magnetostriction as a correction to the magnetocrystalline anisotropy. The effect of magnetostriction was considerably suppressed by the exchange-averaging effect. The estimated effective random magnetoelastic anisotropy for nanocrystalline α-Fe reached as low as 18.6 J/m3, but this static effect could not explain the high excess loss at high frequencies observed in the experiments. The results of this research could provide new design criteria for high-performance soft magnetic materials based on low magnetostriction to reduce the excess loss. The energy loss mechanism due to magnetostriction was clarified by analytical formulation considering the viscosity of magnetic materials. Effects of magnetostriction have been focused on contributions to magnetic anisotropy. However, our formulation shows that the magnetic anisotropy due to magnetostriction cannot explain excess losses in nanocrystalline soft magnetic materials, and the viscosity causes resistance forces acting on domain wall motions. This viscous resistance dissipates the magnetic energy and generates the energy loss, which has the same frequency dependence as anomalous eddy current loss. The results of this research provide new design criteria for ultra-efficient soft magnetic materials.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-12"},"PeriodicalIF":8.6,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00538-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140298485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-22DOI: 10.1038/s41427-024-00535-x
Shijia Tang, Yue Yan, Xiaoli Lu, Peng Wang, Xueqin Xu, Ke Hu, Sen Yan, Zhaobin Guo, Xiao Han, Feimin Zhang, Ning Gu
Physical factors in the cellular microenvironment have critical effects on stem cell differentiation. The utilization of physical factors to promote the osteogenic differentiation of stem cells has been established as a new strategy for developing bone tissue engineering scaffolds. In this context, scaffolds with multiscale anisotropy are considered to possess biomimetic properties, which are advantageous for their biological performance. In the present study, a novel magnetic anisotropic hydrogel (MAH) with magnetic and topographic anisotropy was designed by combining static magnetic field-induced magnetic nanomaterials and a hydrogel. In in vitro studies, the MAH exhibited excellent biocompatibility and osteogenic bioactivity. The alkaline phosphatase activity and the expression of osteogenic-related genes and proteins induced by the MAH were greater than those induced by the pure PEGDA–GelMA hydrogel (PGH) and the magnetic isotropic hydrogel (MIH). In addition, the present study revealed that the dual anisotropic properties of the MAH activated the NOTCH1/2 pathway by upregulating SNHG5 and downstream SIRT6, which modulates the level of NOTCH1/2 by antagonizing DNMT1 protein stability, ultimately inducing the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Furthermore, the MAH, MIH, and PGH were tested for in vivo bone regeneration in rabbits with femur defects, and the results demonstrated that the MAH effectively stimulated bone regeneration. Taken together, these findings suggest that this magnetically and topographically anisotropic biomimetic hydrogel might be a promising candidate for application in the field of bone tissue regeneration. A novel magnetic anisotropic hydrogel (MAH) with magnetic and topographic anisotropy was designed by combining static magnetic field-induced magnetic nanomaterials and a hydrogel. The duel anisotropic hydrogel promotes osteogenic differentiation of BMSCs through upregulating SNHG5 and downstream SIRT6, which modulated the level of NOTCH1/2 by antagonizing DNMT1 protein stability.
{"title":"Nanocomposite magnetic hydrogel with dual anisotropic properties induces osteogenesis through the NOTCH-dependent pathways","authors":"Shijia Tang, Yue Yan, Xiaoli Lu, Peng Wang, Xueqin Xu, Ke Hu, Sen Yan, Zhaobin Guo, Xiao Han, Feimin Zhang, Ning Gu","doi":"10.1038/s41427-024-00535-x","DOIUrl":"10.1038/s41427-024-00535-x","url":null,"abstract":"Physical factors in the cellular microenvironment have critical effects on stem cell differentiation. The utilization of physical factors to promote the osteogenic differentiation of stem cells has been established as a new strategy for developing bone tissue engineering scaffolds. In this context, scaffolds with multiscale anisotropy are considered to possess biomimetic properties, which are advantageous for their biological performance. In the present study, a novel magnetic anisotropic hydrogel (MAH) with magnetic and topographic anisotropy was designed by combining static magnetic field-induced magnetic nanomaterials and a hydrogel. In in vitro studies, the MAH exhibited excellent biocompatibility and osteogenic bioactivity. The alkaline phosphatase activity and the expression of osteogenic-related genes and proteins induced by the MAH were greater than those induced by the pure PEGDA–GelMA hydrogel (PGH) and the magnetic isotropic hydrogel (MIH). In addition, the present study revealed that the dual anisotropic properties of the MAH activated the NOTCH1/2 pathway by upregulating SNHG5 and downstream SIRT6, which modulates the level of NOTCH1/2 by antagonizing DNMT1 protein stability, ultimately inducing the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Furthermore, the MAH, MIH, and PGH were tested for in vivo bone regeneration in rabbits with femur defects, and the results demonstrated that the MAH effectively stimulated bone regeneration. Taken together, these findings suggest that this magnetically and topographically anisotropic biomimetic hydrogel might be a promising candidate for application in the field of bone tissue regeneration. A novel magnetic anisotropic hydrogel (MAH) with magnetic and topographic anisotropy was designed by combining static magnetic field-induced magnetic nanomaterials and a hydrogel. The duel anisotropic hydrogel promotes osteogenic differentiation of BMSCs through upregulating SNHG5 and downstream SIRT6, which modulated the level of NOTCH1/2 by antagonizing DNMT1 protein stability.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-15"},"PeriodicalIF":8.6,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00535-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magnetic skyrmions with nontrivial topologies have great potential to serve as memory cells in novel spintronic devices. Small skyrmions were theoretically and experimentally confirmed to be generated under the influence of external fields in ferrimagnetic films via Dzyaloshinskii–Moriya interactions (DMIs). However, this topological state has yet to be verified in ferrimagnetic crystals, especially in the absence of external fields and DMIs. Here, spontaneous biskyrmions were directly observed in the Tb0.2Gd0.8Co2 ferrimagnetic crystal with a Kagome lattice using Lorentz transmission electron microscopy. The high-density biskyrmions exhibited a small size (approximately 50 nm) over a wide temperature range, were closely related to subtle magnetic interaction competition, and coexisted with some broken stripes that could be easily converted into zero-field biskyrmions by utilizing proper field-cooling manipulation. These results can be used to establish a platform for investigating functional sub-50-nm skyrmions in ferrimagnetic crystals and to facilitate advanced applications in magnetic devices. Scientists have found a new method to control small skyrmions, which are tiny magnetic patterns, in ferrimagnetic materials (materials that have a net magnetic moment even without an external magnetic field arising from the two opposite magnetic sublattices). The research, led by S.L. Zuo and K.M. Qiao, revealed that these skyrmions can be maintained in ferrimagnetic materials without requiring an external magnetic field. The researchers used a technique called Lorentz transmission electron microscopy to observe the skyrmions in a specific ferrimagnetic crystal, Tb0.2Gd0.8Co2. They discovered that the skyrmions remained stable across a broad temperature range and could be easily controlled by altering the temperature or applying a minor magnetic field. This finding could be crucial for the creation of future spintronic devices, devices that use the rotation of electrons to store and process data. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
{"title":"Spontaneous Small Biskyrmions in a Centrosymmetric Rare-Earth Kagome Ferrimagnet","authors":"Shulan Zuo, Kaiming Qiao, Zhan Wang, Ying Zhang, Chengbao Jiang, Baogen Shen","doi":"10.1038/s41427-024-00534-y","DOIUrl":"10.1038/s41427-024-00534-y","url":null,"abstract":"Magnetic skyrmions with nontrivial topologies have great potential to serve as memory cells in novel spintronic devices. Small skyrmions were theoretically and experimentally confirmed to be generated under the influence of external fields in ferrimagnetic films via Dzyaloshinskii–Moriya interactions (DMIs). However, this topological state has yet to be verified in ferrimagnetic crystals, especially in the absence of external fields and DMIs. Here, spontaneous biskyrmions were directly observed in the Tb0.2Gd0.8Co2 ferrimagnetic crystal with a Kagome lattice using Lorentz transmission electron microscopy. The high-density biskyrmions exhibited a small size (approximately 50 nm) over a wide temperature range, were closely related to subtle magnetic interaction competition, and coexisted with some broken stripes that could be easily converted into zero-field biskyrmions by utilizing proper field-cooling manipulation. These results can be used to establish a platform for investigating functional sub-50-nm skyrmions in ferrimagnetic crystals and to facilitate advanced applications in magnetic devices. Scientists have found a new method to control small skyrmions, which are tiny magnetic patterns, in ferrimagnetic materials (materials that have a net magnetic moment even without an external magnetic field arising from the two opposite magnetic sublattices). The research, led by S.L. Zuo and K.M. Qiao, revealed that these skyrmions can be maintained in ferrimagnetic materials without requiring an external magnetic field. The researchers used a technique called Lorentz transmission electron microscopy to observe the skyrmions in a specific ferrimagnetic crystal, Tb0.2Gd0.8Co2. They discovered that the skyrmions remained stable across a broad temperature range and could be easily controlled by altering the temperature or applying a minor magnetic field. This finding could be crucial for the creation of future spintronic devices, devices that use the rotation of electrons to store and process data. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-7"},"PeriodicalIF":8.6,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00534-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140154952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.1038/s41427-024-00533-z
Wang Ding, Yuxiang Ge, Tikai Zhang, Cheng Zhang, Xiaofan Yin
Bone tissue engineering is pivotal in facilitating bone reconstruction by promoting persistent angiogenesis and osteogenesis. Initially, the hot gel composite hydrogel scaffold technique was employed. However, to address various limitations, numerous gel structures have since been developed, including osteogenic gellan gels, semi-interpenetrating network hydrogels, photoinduced crosslinking methacrylate gels, and supramolecular hydrogels. This review examines the mechanisms, formation principles, and medical benefits of these gel structures. In addition, novel bioengineering techniques to regulate human bone growth are expected to emerge in the future. This work is expected to significantly expedite the advancement of hydrogel membranes in the field of bone repair. Despite years of exploration, numerous challenges remain unresolved in the field of hydrogels and hydrogel membranes for bone repair. In this review, we provide a comprehensive overview of the fundamental principles and current development status of hydrogel materials for bone repair, including their mechanisms, formation principles, and medical benefits in bone regeneration. Additionally, we summarize recent effective strategies to develop advanced hydrogels and technical approaches for bone repair while also discussing future directions.
{"title":"Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration","authors":"Wang Ding, Yuxiang Ge, Tikai Zhang, Cheng Zhang, Xiaofan Yin","doi":"10.1038/s41427-024-00533-z","DOIUrl":"10.1038/s41427-024-00533-z","url":null,"abstract":"Bone tissue engineering is pivotal in facilitating bone reconstruction by promoting persistent angiogenesis and osteogenesis. Initially, the hot gel composite hydrogel scaffold technique was employed. However, to address various limitations, numerous gel structures have since been developed, including osteogenic gellan gels, semi-interpenetrating network hydrogels, photoinduced crosslinking methacrylate gels, and supramolecular hydrogels. This review examines the mechanisms, formation principles, and medical benefits of these gel structures. In addition, novel bioengineering techniques to regulate human bone growth are expected to emerge in the future. This work is expected to significantly expedite the advancement of hydrogel membranes in the field of bone repair. Despite years of exploration, numerous challenges remain unresolved in the field of hydrogels and hydrogel membranes for bone repair. In this review, we provide a comprehensive overview of the fundamental principles and current development status of hydrogel materials for bone repair, including their mechanisms, formation principles, and medical benefits in bone regeneration. Additionally, we summarize recent effective strategies to develop advanced hydrogels and technical approaches for bone repair while also discussing future directions.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-18"},"PeriodicalIF":8.6,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00533-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140072210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1038/s41427-024-00532-0
Jamin Lee, Keundong Lee, Kyumeen Kang, Asad Ali, Dong Wook Kim, Hyerim Ahn, Gwanho Ko, Myunghwan Choi, Youngbin Tchoe, Hye Yoon Park, Gyu-Chul Yi
Here, we report the fabrication of transparent multichannel vertical nanotube electrode arrays for detecting cellular activity and optically imaging neuronal networks. To fabricate these transparent electrode arrays, position- and morphology-controlled ZnO nanotube arrays consisting of ultrathin nanowalls were grown on transparent graphene layers and coated with Ti/Au metal layers. Using these multichannel arrays, electrophysiological signals were individually recorded from primary mouse hippocampal neurons and recorded distinctive intracellular potential-like signals. Moreover, the transparent electrode array enabled fluorescence imaging of neuron cell bodies and neurite connections. This transparent graphene- and nanotube-based recording device is proposed to greatly increase the versatility of capabilities for investigating neuronal activity through simultaneous recording and imaging of neuron cultures. The figure depicts a new type of transparent electrode recording array made of vertically aligned zinc oxide nanotubes grown on graphene (top middle). The nanotubes are formed by sharp nanowalls to penetrate the cell (top left) while transparent graphene layers allow imaging the neurons using with conventional microscopy (top right). As a result, simultaneous recording of electrical signals was obtained from multiple neurons at single-cell resolution. Moreover, the signals had distinguishable waveforms that implicated extracellular- and intracellular-like electrophysiological voltage changes (bottom).
{"title":"Transparent vertical nanotube electrode arrays on graphene for cellular recording and optical imaging","authors":"Jamin Lee, Keundong Lee, Kyumeen Kang, Asad Ali, Dong Wook Kim, Hyerim Ahn, Gwanho Ko, Myunghwan Choi, Youngbin Tchoe, Hye Yoon Park, Gyu-Chul Yi","doi":"10.1038/s41427-024-00532-0","DOIUrl":"10.1038/s41427-024-00532-0","url":null,"abstract":"Here, we report the fabrication of transparent multichannel vertical nanotube electrode arrays for detecting cellular activity and optically imaging neuronal networks. To fabricate these transparent electrode arrays, position- and morphology-controlled ZnO nanotube arrays consisting of ultrathin nanowalls were grown on transparent graphene layers and coated with Ti/Au metal layers. Using these multichannel arrays, electrophysiological signals were individually recorded from primary mouse hippocampal neurons and recorded distinctive intracellular potential-like signals. Moreover, the transparent electrode array enabled fluorescence imaging of neuron cell bodies and neurite connections. This transparent graphene- and nanotube-based recording device is proposed to greatly increase the versatility of capabilities for investigating neuronal activity through simultaneous recording and imaging of neuron cultures. The figure depicts a new type of transparent electrode recording array made of vertically aligned zinc oxide nanotubes grown on graphene (top middle). The nanotubes are formed by sharp nanowalls to penetrate the cell (top left) while transparent graphene layers allow imaging the neurons using with conventional microscopy (top right). As a result, simultaneous recording of electrical signals was obtained from multiple neurons at single-cell resolution. Moreover, the signals had distinguishable waveforms that implicated extracellular- and intracellular-like electrophysiological voltage changes (bottom).","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-9"},"PeriodicalIF":8.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00532-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140009549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：