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Nurturing New Life: Examining Pregnant Women’s Knowledge and Perception of Prenatal Care and Breastfeeding 孕育新生命:孕妇产前护理与母乳喂养知识与认知的调查
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175287
Mohammad Mustafa Farooq Khan, Muhammad Talha Mumtaz, Muhammad Uzair, Nimra Aslam Khan, Muhammad Danyal Khalid, M. Khan
Background: The health of pregnant women and their newborns is critical. Prenatal care and breastfeeding are fundamental components of optimal maternal and child health. Despite the well-recognized importance of these practices, the worldwide prevalence of suboptimal antenatal care and breastfeeding remains high. The lack of awareness and knowledge among pregnant women regarding these practices is a leading cause. This study aimed to explore the attitudes, knowledge, and practices of pregnant women regarding antenatal care and breastfeeding. Objective: to identify critical areas for intervention and highlight gaps in knowledge to offer a foundation for future research and awareness-raising. Methodology: A cross-sectional study was conducted in Lahore from 1st of January, 2022 to 1st of March, 2022. The data was collected of pregnant women from Ghurki Trust Teaching Hospital, Lahore, For this cross Sectional survey 400 pregnant women, ranging from <20 to 40 years or above were approached. Results: The majority of the respondents had education up to secondary level, and half had their previous baby delivered at home. The findings revealed that the majority of pregnant women had visited less than four times for prenatal checkups during the current pregnancy and expressed a willingness to come for proper prenatal checkups in their next pregnancy. Practical Implication: In order to achieve the best possible outcomes for both the mother and the baby, it is imperative to have educational programs aimed at enhancing the knowledge around prenatal care and breastfeeding practices amongst expectant mothers. Conclusion: Respondents were aware of the benefits of breastfeeding, but their knowledge of optimal breastfeeding practices, including colostrum feeding, was insufficient. Addressing these gaps in knowledge and practice is essential through community awareness programs, health care provider training, and support mechanisms for new mothers. Ultimately, improving maternal and child health will enhance the welfare of families and the community as a whole. Keywords: Pregnant, Knowledge and Perception, Prenatal Care, Breastfeeding
背景:孕妇及其新生儿的健康至关重要。产前护理和母乳喂养是最佳妇幼保健的基本组成部分。尽管这些做法的重要性得到公认,但在世界范围内,不理想的产前保健和母乳喂养的发生率仍然很高。孕妇对这些做法缺乏认识和知识是一个主要原因。本研究旨在探讨孕妇对产前护理和母乳喂养的态度、知识和做法。目的:确定需要干预的关键领域,突出知识差距,为今后的研究和提高认识奠定基础。方法:横断面研究于2022年1月1日至2022年3月1日在拉合尔进行。数据收集自拉合尔Ghurki信托教学医院的孕妇。在这项横断面调查中,400名年龄在<20至40岁或以上的孕妇进行了接触。结果:大多数受访者受教育程度达到中等水平,一半的人在家中分娩。调查结果显示,大多数孕妇在当前怀孕期间进行产前检查的次数少于四次,并表示愿意在下次怀孕时进行适当的产前检查。实际意义:为了达到母亲和婴儿的最佳可能结果,必须有旨在提高产前护理和母乳喂养实践知识的教育计划。结论:受访者意识到母乳喂养的好处,但他们对最佳母乳喂养做法(包括初乳喂养)的了解不足。必须通过社区宣传方案、卫生保健提供者培训和新妈妈支持机制来解决这些知识和实践方面的差距。最终,改善妇幼保健将提高家庭和整个社区的福利。关键词:妊娠;知识与感知;产前护理
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引用次数: 0
Principles of Treating the Sequelae of Perthes Disease 柏氏病后遗症的治疗原则
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175290
M. Arsalan, Midrarullah Khan, Mauzzmah Shahid, Z. Qamar, Sana Akhlaq, Assad Ullah
Background: Perthes disease is a form of juvenile idiopathic osteonecrosis characterized by temporary bone mortality due to inadequate blood supply to the femoral head. Objectives: This cross-sectional study aimed to evaluate the treatment outcomes and sequelae of Perthes Disease and to identify the most effective treatment modalities for managing its sequelae. Methods: The research enrolled 59 Perthes Disease patients who had completed treatment at our institution between 2021 and 2022. The information pertaining to demographic characteristics, clinical presentations, radiological findings, specific treatments administered, and follow-up records were collected. Pain levels and hip functionality were secondary outcome measures. The Harris Hip Score (HHS) was used to assess the primary outcome of quality of life. Practical Implication: The practical implications for treating the sequelae of Perthes disease include early detection, a multidisciplinary approach, conservative management, surgical interventions when necessary, rehabilitation and physical therapy, long-term monitoring, and patient and family education. Timely diagnosis, collaboration among healthcare professionals, tailored treatment plans, and regular follow-up are important for optimizing outcomes and managing the condition effectively. Results: The average age of the study population was 4.76+1.10 years, with a higher proportion of males. Left-sided (59.32%) participation was more prevalent than right-sided (37.28%) participation (p<0.05). The disease's duration differed between patients. The majority of participants exhibited clinical symptoms such as hip or groin pain, limping, restricted hip movement, and deformities. The most prevalent treatment modality (p<0.05) was physical therapy (52.54%), followed by orthotic devices (30.50%) and surgical interventions (16.94%). Surgical procedures employed both extra-articular (70%) and intra-articular techniques (10%) (p<0.05). Conclusion: Multimodal, patient-specific approach is essential for managing Perthes disease sequelae. Physical therapy was the primary modality of care, while surgical interventions were employed selectively. Significant improvements were observed in pain reduction, functional outcomes, deformity correction, and ROM as a result of the treatment. These findings provided important insights into the management of Perthes disease and highlighted the need for individualized treatment strategies to achieve optimal patient outcomes. Keywords: Harris Hip Score; Perthes Disease; Orthopedic deformities; Orthotic devices; Radiological examination.
背景:Perthes病是一种青少年特发性骨坏死,以股骨头供血不足导致暂时性骨死亡为特征。目的:本横断面研究旨在评估Perthes病的治疗结果和后遗症,并确定最有效的治疗方式来管理其后遗症。方法:研究纳入了2021年至2022年期间在我院完成治疗的59例Perthes病患者。收集了有关人口统计学特征、临床表现、放射学表现、特定治疗和随访记录的信息。疼痛程度和髋关节功能是次要指标。Harris髋关节评分(HHS)用于评估生活质量的主要结局。实际意义:治疗珀特氏病后遗症的实际意义包括早期发现、多学科方法、保守管理、必要时手术干预、康复和物理治疗、长期监测以及患者和家属教育。及时诊断、医疗保健专业人员之间的合作、量身定制的治疗计划和定期随访对于优化结果和有效地管理病情非常重要。结果:研究人群平均年龄为4.76+1.10岁,男性比例较高。左侧参与率(59.32%)高于右侧参与率(37.28%)(p<0.05)。不同病人的病程不同。大多数参与者表现出临床症状,如髋关节或腹股沟疼痛、跛行、髋关节活动受限和畸形。治疗方式以物理治疗为主(52.54%),矫形器次之(30.50%),手术治疗次之(16.94%)。手术采用关节外技术(70%)和关节内技术(10%)(p<0.05)。结论:多模式、患者特异性的治疗方法是治疗珀特氏病后遗症的必要方法。物理治疗是主要的治疗方式,而手术干预是选择性的。治疗后,疼痛减轻、功能预后、畸形矫正和关节活动度均有显著改善。这些发现为Perthes病的管理提供了重要的见解,并强调了个性化治疗策略的必要性,以达到最佳的患者结果。关键词:Harris髋关节评分;佩尔特斯疾病;骨科畸形;矫正的设备;放射学检查。
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引用次数: 0
Infection with Helicobacter Pylori and the Risk of Iron Deficiency Anaemia 幽门螺杆菌感染与缺铁性贫血的风险
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175253
Rashidul Karim, Wajid Iqbal, Mahwash Mengal, M. A. Mengal, Muhammad Mohsin Sial, Ahmed Latif Chaudhary
Objective: The objective of this research is to determine the frequency of a condition known as iron deficiency anaemia (IDA) among people who have been infected with Helicobacter pylori. Study Design: Cross-sectional/ Prospective study Place and Duration: Hayatabad Medical Complex Peshawar in the duration from November, 2022 to April, 2023. Methods: There were a total of 116 patients with Helicobacter pylori infections, whose ages ranged from 20 to 70. After collecting demographic information from each participant (including age, sex, BMI, education level, and residence), each patient gave written informed consent. Subjects' blood was tested for iron, transferrin saturation, ferritin, which and total iron-binding capacity. Histopathology, stool antigen testing, a fast urease test, and a urea breath test can all diagnose Helicobacter pylori infection. All statistical analyses were performed in SPSS 25.0. Results: There were 74 (63.8%) females and 42 (36.2%) males in our study. Patients mean age was 28.13±14.68 years and had mean BMI 23.6±11.26 kg/m2. The mean Hemoglobin level of the patients was 11.9±1.8 (g/dl), the iron level was 47.11±6.49 (ug/dl) and mean ferritin level was 119.6±32.68 (ng per ml). Among 116 cases, 42 (36.2%) patients had Iron Deficiency Anemia (IDA). Conclusion: An increased incidence of iron deficiency anaemia was seen among individuals with Helicobacter pylori infections; the majority of these patients were adult females. Keywords: H.pylori infection, Prevalence, Iron Deficiency Anemia (IDA),
目的:本研究的目的是确定被称为缺铁性贫血(IDA)的人谁已经感染幽门螺杆菌的频率。研究设计:横断面/前瞻性研究地点和时间:2022年11月至2023年4月期间,白沙瓦Hayatabad医疗中心。方法:116例幽门螺杆菌感染患者,年龄20 ~ 70岁。在收集每位参与者的人口统计信息(包括年龄、性别、BMI、教育程度和居住地)后,每位患者给予书面知情同意。检测受试者血液中铁含量、转铁蛋白饱和度、铁蛋白、总铁结合能力。组织病理学、粪便抗原测试、快速脲酶测试和尿素呼气测试都可以诊断幽门螺杆菌感染。所有统计分析均采用SPSS 25.0软件进行。结果:女性74例(63.8%),男性42例(36.2%)。患者平均年龄28.13±14.68岁,平均BMI为23.6±11.26 kg/m2。患者血红蛋白平均水平为11.9±1.8 (g/dl),铁水平为47.11±6.49 (ug/dl),铁蛋白平均水平为119.6±32.68 (ng / ml)。116例患者中有42例(36.2%)为缺铁性贫血(IDA)。结论:幽门螺杆菌感染人群缺铁性贫血发生率增高;这些患者大多为成年女性。关键词:幽门螺杆菌感染;患病率;缺铁性贫血;
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引用次数: 0
Examine the Risk Factors for Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention (PCI) and the Prevalence of this Complication 检查经皮冠状动脉介入治疗(PCI)患者造影剂肾病的危险因素及其并发症的发生率
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175245
Gauhar Rahman, Hibba Aziz, Naveed Yaqoob, R. Yasmin, M. Tareen, Faizan Ahmed
Objective: The purpose of this study was to determine the incidence of contrast-induced nephropathy and risk variables among patients undergoing multi-vessel percutaneous coronary intervention (PCI). Study Design: Prospective / Observational study Place and Duration: Department of Interventional Cardiology, Peshawar Institute of Cardiology Peshawar in the duration from November 2022 to April, 2023. Methods: There were 168 patients of both genders with ages 20-70 years were presented in this study. Data on enrolled patients' age, gender, BMI, marital status and education level were collected after receiving written permission from each patient. This research included people who had undergone a percutaneous coronary intervention. Serum creatinine >0.5mg/dl from the baseline value was classified as contrast induced nephropathy. CIN-related risk factors were studied. Data was analyzed using SPSS 22.0. Results: Patients mean age was 49.8±19.44 years and with mean body mass index 24.1±7.37 kg/m2. 90 patients were males. CIN was found in 42 (25%) cases. Contrast volume, hypertension, diabetes mellitus, and age >60 were the most common risk factors for CIN. Conclusion: Contrast-induced nephropathy is a serious danger for patients undergoing PCI. Anemia (age >60), diabetes mellitus (contrast volume >150 ml), and heart failure were found to increase the likelihood of developing CIN. Keywords: Contrast Induced Nephropathy, Percutaneous Coronary Intervention, Risk Factors
目的:本研究的目的是确定多支经皮冠状动脉介入治疗(PCI)患者造影剂肾病的发生率和危险因素。研究设计:前瞻性/观察性研究地点和时间:2022年11月至2023年4月白沙瓦白沙瓦心脏病研究所介入心脏病科。方法:对168例年龄20 ~ 70岁的男女患者进行分析。在获得每位患者的书面许可后,收集入组患者的年龄、性别、BMI、婚姻状况和受教育程度等数据。这项研究包括接受过经皮冠状动脉介入治疗的人。血清肌酐比基线值>0.5mg/dl为造影剂肾病。研究cin相关危险因素。数据采用SPSS 22.0进行分析。结果:患者平均年龄49.8±19.44岁,平均体重指数24.1±7.37 kg/m2。男性90例。42例(25%)发现CIN。造影剂、高血压、糖尿病和年龄>60岁是CIN最常见的危险因素。结论:造影剂肾病是PCI患者的严重危险。贫血(年龄>60岁)、糖尿病(造影剂>150 ml)和心力衰竭可增加发生CIN的可能性。关键词:造影剂肾病,经皮冠状动脉介入治疗,危险因素
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引用次数: 0
Outcomes of Late Presenters with Acute Inferior Wall Myocardial Infarction Complicated by Complete Heart Block Treated with Percutaneous Coronary Intervention 急性下壁心肌梗死并发完全性心脏传导阻滞晚期患者经皮冠状动脉介入治疗的结果
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175256
Syed Tahir Shah, I. Shah, N. Hadi, M. Rauf, Tariq Nawaz, S. Ullah
Objective: The objective of this study was to evaluate the outcomes of delayed presenters with acute inferior wall MI complicated by complete heart block treated by PCI of culprit artery. Methods: A descriptive cross-sectional study conducted on 40 patients with late presentation of either 48 hours or more with acute inferior wall MI complicated by complete heart block were included. All patients underwent coronary angiography and PCI of culprit vessel attempted. Outcomes were measured in terms of restoration of normal sinus rhythm along with heart block recovery time, requirement for implantation of permanent pacemaker and in hospital mortality. The statistical analysis was performed using SPSS 24. Results: The mean age was 55.73 ± 7.679. Male were 65% (n=26), diabetes 62.5% (n=25), hypertension 57.5 (n=23), smoking 30% (n=12) and dyslipidemia 52.5% (n=21). Mean delay in presentation 69.35 ± 11.132 hours. Mean restoration time 69.25 ± 10.95 hours, with minimum of 48 hrs & maximum 86 hrs. Mean tropinin I level 1588.97± 996.70 pg/ml. Mean Ejection fraction 44.8± 9.48 %. Successful PCI has a significant correlation with recovery time (p=.004). There was no in hospital mortality. All restores normal sinus rhythm and no patient needed permanent pacemaker. Successful PCI has a significant correlation with recovery time (p=.004). Conclusion: Successful PCI of culprit artery in late presenter of CHB with acute inferior MI results in restoration of NSR all patients with reduction in heart block recovery time and no in hospital death. Keywords: Acute inferior wall MI, Complete heart block, PCI, late presenter
目的:评价急性下壁心肌梗死并发完全性心脏传导阻滞的迟发患者行主犯动脉PCI治疗的结果。方法:对40例迟发48小时或更长时间的急性下壁心肌梗死合并完全性心脏传导阻滞患者进行描述性横断面研究。所有患者均行冠状动脉造影和主犯血管PCI。结果是根据恢复正常窦性心律、心脏传导阻滞恢复时间、植入永久性起搏器的需求和住院死亡率来衡量的。采用SPSS 24进行统计分析。结果:平均年龄55.73±7.679岁。男性占65% (n=26),糖尿病占62.5% (n=25),高血压占57.5 (n=23),吸烟占30% (n=12),血脂异常占52.5% (n=21)。平均出现延迟69.35±11.132小时。平均恢复时间69.25±10.95小时,最小48小时,最大86小时。平均tropinin I水平1588.97±996.70 pg/ml。平均射血分数44.8±9.48%。PCI成功与恢复时间有显著相关性(p= 0.004)。没有住院死亡率。所有恢复正常的窦性心律,病人不需要永久性起搏器。PCI成功与恢复时间有显著相关性(p= 0.004)。结论:迟发期CHB合并急性下壁心肌梗死患者行主犯动脉PCI治疗成功,可使所有患者心脏传导阻滞恢复时间缩短,无院内死亡病例。关键词:急性下壁心肌梗死,完全心脏传导阻滞,PCI,晚期患者
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引用次数: 0
Comparison of Outcome of Lactose-Free Formula Milk with Yogurt in Children with Acute Diarrhea 无乳糖配方奶与酸奶治疗急性腹泻患儿的疗效比较
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175281
Mahjabeen Akram, Sadam Hussain, Muhammad Wasim Salim, Faizan Pervaiz, S. Karim, H. Khan
Background: Diarrhea is one of the most common problems in Pakistan where Khyber Pakhtunkhwa has the maximum prevalence i.e, 28% followed by Sindh (23%), Punjab (22%), and Baluchistan (12%). According to WHO every year 1.5 million children under 5 years, die just because of diarrhea. Therefore, this study aimed to look at the effect of lactose-free formula milk versus homemade plain yogurt in children with acute diarrhea. Methods: A randomized controlled trial was carried out on 60 children of age 4-24 months, 30 in each group in the Department of Pediatrics, Services Hospital Lahore. Group 1 was given yogurt while lactose-free milk was given to group 2. The duration of resolution of diarrhea was noted in hours and data was statistically analyzed using SPSS version 20. Practical Implication: The practical implication of comparing lactose-free formula milk with yogurt as a dietary intervention for children with acute diarrhea involves several considerations. Firstly, the severity and duration of diarrhea should be evaluated to determine the appropriate intervention. Secondly, the age and nutritional needs of the child should be taken into account. Thirdly, the availability and acceptance of lactose-free formula milk and yogurt in the local context should be considered. Additionally, the potential benefits and drawbacks of each option, such as the nutritional content, ease of digestion, and probiotic properties of yogurt, need to be assessed. It is important to consult with healthcare professionals and make an informed decision based on the specific circumstances to promote optimal outcomes in managing acute diarrhea in children. Results: Out of 60 children, 26 (43.33%) were male and 34 (56.67%) were female. In groups 1 and 2, the mean duration of resolution of diarrhea (outcome) was 43.9 ± 7.30 hours and 71.57 ± 12.92 hours respectively. Group 1 patients’ treatment showed a significant difference in the outcome than group 2 patients (P value= 0.00). However, the treatment effect on gender was found non-significant (P value= 0.48). The outcome in females was 43.6 ± 7.5 hours with yogurt and 70.6 ± 8.4 hours with lactose-free milk while in males the outcome was 44.3 ± 8.6 hours with yogurt and 73.1 ± 9.1 hours with lactose-free milk. Conclusion: The use of yogurt is better than lactose-free formula milk for the resolution of diarrhea. Keywords: Lactose-free formula milk, homemade plain yogurt, diarrhea.
背景:腹泻是巴基斯坦最常见的问题之一,其中开伯尔-普赫图赫瓦省的患病率最高,为28%,其次是信德省(23%)、旁遮普(22%)和俾路支省(12%)。据世卫组织统计,每年有150万5岁以下儿童死于腹泻。因此,本研究旨在观察无乳糖配方奶与自制原味酸奶对急性腹泻儿童的影响。方法:对拉合尔服务医院儿科4 ~ 24月龄儿童60例进行随机对照试验,每组30例。1组给予酸奶,2组给予无乳糖牛奶。腹泻消退时间以小时为单位记录,数据采用SPSS 20进行统计分析。实际意义:比较无乳糖配方奶和酸奶作为急性腹泻儿童饮食干预的实际意义涉及几个考虑因素。首先,应评估腹泻的严重程度和持续时间,以确定适当的干预措施。其次,应考虑到儿童的年龄和营养需要。第三,应考虑无乳糖配方奶和酸奶在当地的可获得性和接受度。此外,每种选择的潜在优点和缺点,如酸奶的营养成分、易消化性和益生菌特性,都需要评估。重要的是咨询医疗保健专业人员,并根据具体情况做出明智的决定,以促进管理儿童急性腹泻的最佳结果。结果:60例患儿中,男26例(43.33%),女34例(56.67%)。1组和2组的平均腹泻缓解时间(结局)分别为43.9±7.30小时和71.57±12.92小时。组1患者治疗后转归与组2患者比较差异有统计学意义(P值= 0.00)。然而,治疗对性别的影响不显著(P值= 0.48)。女性饮用酸奶的结果为43.6±7.5小时,无乳糖牛奶的结果为70.6±8.4小时;男性饮用酸奶的结果为44.3±8.6小时,无乳糖牛奶的结果为73.1±9.1小时。结论:酸奶对腹泻的缓解效果优于无乳糖配方奶。关键词:无乳糖配方奶,自制原味酸奶,腹泻
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引用次数: 0
Examining Authorship Dynamics, Publication Patterns, and Affiliations in the Pakistan Journal of Medical and Health Sciences (PJMHS) from 2009-2019 2009-2019年《巴基斯坦医学与健康科学杂志》(PJMHS)作者动态、出版模式和隶属关系的研究
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175277
Zameer Hussain Baladi, Ghulam Farid, Ayesha Gulzar, Manzoor Hussain, S. Iftikhar, Maryam Naz
Introduction: The Pakistan Journal of Medical and Health Sciences have been peer-reviewed and is included in the Scopus-Elsevier database. This study represents (PJMHS)'s contribution to research productivity from 2019 to 2009. Methods and Materials: The published data records were obtained from the PJMHS website and the Scopus-Elsevier database for MS Office Excel Sheet tabulation. The frequency of publications, the type of papers, the use of pages, citations, and the initial author's affiliation with their country. Results: In 43 issues, 15401 (4%) authors wrote 3817 items in seven categories. The average number of pages consumed was (2.8%), with 896 (23.4%) citations in publications. The collaboration of three authors provided 1339 (36.6%) papers and received the top spot, while four authors, 3344 (21.7%), contributed 836 (22%). The first authors from 29 nations engaged in publications, with Pakistan leading the way with 3484 (91%), Iran second with 79 (2%), Indonesia third with 77 (2%), and the Kingdom of Saudi Arabia fourth with 65 (1.7%). Practical Implication: The information assess the influence and relevance of the research published in the Pakistan Journal of Medical and Health Sciences. In nut-shell, the published data empowers readers to stay informed about the journal's publication trends, authorship patterns, and the breadth of content available. It enables researchers to identify potential collaborators, explore different document types, and gauge the impact of published articles through citation analysis. Conclusion: Pakistan Journal of Medical and Health Sciences (PJMHS) is a peer-reviewed journal that is published continuously and assists medical and health sciences research communities in gaining their attention in sharing ideas on a reciprocal basis from similar specialties or sub-specialties of common disciplines Keywords: Bibliometric, Pakistan Journal of Medical and Health Sciences, Pakistan, medical education and research, bibliometric, Zameer Baladi.
导言:《巴基斯坦医学和健康科学杂志》已经过同行评议,并被纳入Scopus-Elsevier数据库。本研究反映了PJMHS在2019 - 2009年间对科研生产力的贡献。方法与材料:从PJMHS网站和Scopus-Elsevier数据库中获取已发表的数据记录,用MS Office Excel Sheet进行制表。出版物的频率,论文的类型,页数的使用,引用,以及最初的作者与他们国家的关系。结果:43期共7大类3817条,15401位(4%)作者。平均消耗页数为(2.8%),出版物引用896次(23.4%)。3位作者共发表论文1339篇(36.6%),位居第一;4位作者共发表论文3344篇(21.7%),共发表论文836篇(22%)。第一作者来自29个国家,其中巴基斯坦以3484人(91%)领先,伊朗以79人(2%)位居第二,印度尼西亚以77人(2%)位居第三,沙特阿拉伯王国以65人(1.7%)位居第四。实际意义:这些信息评估了发表在《巴基斯坦医学和健康科学杂志》上的研究的影响和相关性。简而言之,发表的数据使读者能够随时了解期刊的出版趋势、作者模式和可用内容的广度。它使研究人员能够识别潜在的合作者,探索不同的文档类型,并通过引用分析来衡量已发表文章的影响。结论:《巴基斯坦医学与健康科学杂志》(PJMHS)是一份连续出版的同行评议期刊,帮助医学和健康科学研究界在互惠的基础上从类似的专业或共同学科的子专业分享想法,从而引起他们的注意。关键词:文献计量学,《巴基斯坦医学与健康科学杂志》,巴基斯坦,医学教育和研究,文献计量学,Zameer Baladi。
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引用次数: 0
Probiotics' Effectiveness in Antibiotic-Induced Diarrhea 益生菌对抗生素性腹泻的疗效
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175240
A. ., A. Ahmad, Ishfaq Ahmad, Q. Din, Abdul Hameed
Objectives: In Lakki Marwat, KPK, Pakistan's Category C hospital, probiotics were utilized to establish its efficiency in countering Antibiotic-Induced Diarrhea. Determine the following was the aim of the secondary Objectives: At the hospital, antibiotics have been found to be a common cause of diarrhea. Its prevalence is noticeable, sometimes sporadically. Probiotics' effectiveness when addressing Diarrhea caused by antibiotics are under evaluation. Probiotic therapy's safety and tolerability are both crucial factors to consider. Materials and Methods: During the timeframe of Jan 2021 to Jan 2022, a study was carried out in Cat-C hospital Lakki Marwat. At the registered medical centre, various patients were included as part of the research. These patients had earlier received antibiotics for their health conditions. To facilitate the treatment, they were all given probiotics in the form of capsules or liquid drops. The University Ethics Board provided approval, and the Helsinki Declaration was followed while conducting the study. Throughout the treatment period, the patients were constantly observed for any gastrointestinal symptoms such as abdominal pain, diarrhea, and nausea. Results: In the study, there were 100 patients who participated, the majority of whom reported experiencing gastrointestinal symptoms while taking antibiotics. Specifically, a whopping 97% of patients noted symptoms. The most common of which was diarrhea, with 78% reporting this issue. However, patients who did take probiotics had less diarrhea than those who did not receive these supplements (P 0.05). Based on these findings, it's clear that probiotics are an effective solution for those who suffer from antibiotic-related discomforts. Keywords: Antibiotic-induced Diarrhea, probiotics, safety, tolerability, Lakki Marwat, Pakistan
目的:在巴基斯坦的C类医院Lakki Marwat,利用益生菌来确定其对抗抗生素引起的腹泻的效率。确定以下是次要目的:在医院,抗生素已被发现是腹泻的常见原因。它的流行是显而易见的,有时是零星的。益生菌在解决抗生素引起的腹泻时的有效性正在评估中。益生菌治疗的安全性和耐受性都是需要考虑的关键因素。材料与方法:在2021年1月至2022年1月期间,在Lakki Marwat Cat-C医院进行研究。在注册的医疗中心,作为研究的一部分,纳入了各种病人。这些病人早先曾因其健康状况接受过抗生素治疗。为了方便治疗,他们都服用了胶囊或液滴形式的益生菌。大学伦理委员会提供了批准,并在进行研究时遵循了赫尔辛基宣言。在整个治疗期间,持续观察患者有无腹痛、腹泻、恶心等胃肠道症状。结果:在这项研究中,有100名患者参与,其中大多数人报告在服用抗生素时出现胃肠道症状。具体来说,高达97%的患者出现了症状。其中最常见的是腹泻,78%的人报告了这个问题。然而,服用益生菌的患者比未服用益生菌的患者腹泻较少(P < 0.05)。基于这些发现,很明显,益生菌对那些患有抗生素相关不适的人来说是一种有效的解决方案。关键词:抗生素性腹泻,益生菌,安全性,耐受性,Lakki Marwat,巴基斯坦
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引用次数: 0
Recent Advances in Vaccine Technology for Viral Infection Management: A Spotlight on Next-Generation Vaccines and Nucleic Acid-Based Platforms 病毒感染管理疫苗技术的最新进展:下一代疫苗和基于核酸的平台
Pub Date : 2023-06-23 DOI: 10.53350/pjmhs2023175261
Muhammad Zahid Ali, Yousra Anwar, Adil Abbas, Namrah Zafar, Zainab Khalid, A. Sattar, M. Usman, Arzoo Nazir, Shahi Zeb
Recent advances in vaccine technology and their uses in viral infection management were the focus of the study. Potential nucleic acid-based platforms for vaccine development, including DNA and RNA vaccines, were also investigated. During the COVID-19 pandemic, a lot of attention was paid to RNA-based vaccinations like mRNA vaccines because of their rapid development and scalability. These vaccines were shown to be effective at eliciting protective immune responses and provided the adaptability to include multiple antigenic sites. Preclinical and clinical research of this magnitude is required for the development and assessment of these innovative vaccine methods. Immunogenicity, side effects, and efficacy were all taken into account. The study highlighted the need for more investigation and cooperation between researchers, physicians, and business allies to speed up the process of turning these novel vaccine strategies into successful therapies against different types of viral infections. Our study demonstrated the potential of viral vectors, nanoparticles, and nucleic acid-based platforms in developing vaccine technology, and it contributes important insights into the design and evaluation of innovative vaccine tactics against viral diseases. These results add to the existing body of knowledge and may help direct future antiviral research and development. Keywords: Vaccine development, Viruses, DNA Vaccines, RNA Vaccines, COVID-19 Vaccines
疫苗技术的最新进展及其在病毒感染管理中的应用是研究的重点。还研究了潜在的基于核酸的疫苗开发平台,包括DNA和RNA疫苗。在2019冠状病毒病大流行期间,mRNA疫苗等基于rna的疫苗因其快速发展和可扩展性而备受关注。这些疫苗被证明能有效地引发保护性免疫反应,并提供了包括多个抗原位点的适应性。开发和评估这些创新的疫苗方法需要进行如此大规模的临床前和临床研究。免疫原性、副作用和疗效都被考虑在内。这项研究强调,需要在研究人员、医生和商业盟友之间进行更多的调查和合作,以加快将这些新型疫苗策略转化为针对不同类型病毒感染的成功疗法的进程。我们的研究证明了病毒载体、纳米颗粒和基于核酸的平台在开发疫苗技术方面的潜力,并为设计和评估针对病毒性疾病的创新疫苗策略提供了重要的见解。这些结果增加了现有的知识体系,并可能有助于指导未来的抗病毒研究和开发。关键词:疫苗研制,病毒,DNA疫苗,RNA疫苗,COVID-19疫苗
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引用次数: 0
Comparison of Efficacy and Safety of Magnesium Sulphate Versus oral Nifedipine in Acute Tocolysis of Preterm Labour 硫酸镁与口服硝苯地平治疗急性早产的疗效和安全性比较
Pub Date : 2023-06-16 DOI: 10.53350/pjmhs2023176168
Rukhsana Saleem, Sara Akram, Farzana Sabir, R. Salam, Nasreen Akhtar, Nimra Bashir, S. Saeed
Aim: To compare the efficacy and safety of magnesium sulphate and oral nifedipine in acute tocolysis of preterm labor. Study design: Randomized controlled trial. Place and duration of study: Department of Obstetrics & Gynecology, DHQ Hospital, Mirpur from 19th October 2019 to 18th April 2020. Methodology: This study included 178 pregnant women with singletons (18 to 40 years of age) assessed through ultrasonography and presented preterm labor. Pregnant women having fetal growth restriction, fetal death, severe preeclampsia, fetal distress, hyperthyroidism,any maternal contraindication for the use of tocolytic drugs, cardiovascular disease, abruptio placentae or placenta-previa were placed in the seclusion criteria of the study. In the group A, oral loading dose of nifedipine 20mg was given. While in group B, magnesium sulphate was injected intravenously with a loading dose of 4 grams over 15 minutes followed by maintenance dose of 2-3 grams/hr. All patients in both groups were evaluated by the researcher herself for prolongation of pregnancy at 48 hours after the start of treatment and efficacy and safety was noted. Results: Efficacy was seen in 80 (89.89%) in group A (Oral nifedipine) and 67 (75.28%) in group B (magnesium sulfate) with p0.019. Safety was seen in 72 (80.90%) in group B (magnesium sulfate) and 83 (93.26%) in group A (oral nifedipine) with p 0.014. Practical Implication: The administration of corticosteroids and also assist in reducing mortality and morbidity related with preterm labor events. Conclusion: This study concluded that oral nifedipine is efficacious and safe than magnesium sulphate for acute tocolysis of preterm labour. Keywords: Tocolytic Agents, Preterm Birth, Magnesium Sulphate.
目的:比较硫酸镁与口服硝苯地平治疗急性早产的疗效和安全性。研究设计:随机对照试验。研究地点和时间:2019年10月19日至2020年4月18日,印度米尔普尔DHQ医院妇产科。方法:本研究纳入178例单胎孕妇(18至40岁),通过超声检查评估并表现为早产。有胎儿生长受限、胎儿死亡、严重先兆子痫、胎儿窘迫、甲状腺功能亢进、任何母体使用溶胎药物禁忌症、心血管疾病、胎盘早剥或胎盘前置的孕妇被置于研究的隔离标准中。A组给予硝苯地平口服负荷剂量20mg。B组在15分钟内静脉注射4克硫酸镁,维持剂量为2-3克/小时。两组患者均在治疗开始后48小时由研究者自行评估妊娠延长情况,并评价其有效性和安全性。结果:A组(口服硝苯地平)有效率80例(89.89%),B组(硫酸镁)有效率67例(75.28%),p < 0.019。B组(硫酸镁)72例(80.90%),A组(口服硝苯地平)83例(93.26%),p < 0.014。实际意义:皮质类固醇的使用也有助于降低与早产事件相关的死亡率和发病率。结论:口服硝苯地平治疗急性早产比硫酸镁有效、安全。关键词:抗早产药物,早产,硫酸镁。
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引用次数: 0
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Pakistan Journal of Medical and Health Sciences
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