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Stem cells differentiation induced by physical stimulation using piezoelectric nanocomposite material 压电纳米复合材料物理刺激诱导干细胞分化
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297810
D. Rouxel, A. Thouvenin, F. Courtout, V. Nguyen, B. Vincent, G. Prieur, É. Velot, N. Merakchi, P. Menu
Bioengineering has become one of the most promising fields in regenerative medicine. Many of its applications have been settled through stem cell research in order to develop innovative stimuli to differentiate the cells into a specific lineage via physical stimulation such as thermal, mechanical or electrical stimuli to avoid the use of biochemical products. Many examples are found in literature, however none of them could provide conclusive answers in this research field. Piezoelectric materials are able to combine mechanical and electrical stimulation. Environments mimicking in vivo conditions are supposed to be the best to induce differentiation process, but these mechanisms are still not fully mastered and very much dependent on cell type. In this poster, we will introduce the experimental setup used to study the effects of physical (i.e. electrical and/or mechanical) stimulation on human mesenchymal stem cells. An overview of the thought process leading to our project is exposed, as well as a brief bibliographical study of electrical stimulation effects on cells. The emphasis will be focused on the piezoelectric materials used in this project. We selected a nanocomposite material, a copolymer P(VDF-TrFE) matrix charged with ZnO nanoparticles, in order to modulate the mechanical and piezoelectric properties of the matrix as well as to provide a better sticking surface favouring cell adhesion.
生物工程已成为再生医学中最有前途的领域之一。它的许多应用都是通过干细胞研究来解决的,目的是通过热、机械或电等物理刺激来开发创新的刺激,使细胞分化成特定的谱系,以避免使用生化产品。文献中有很多例子,但没有一个能在这个研究领域提供结论性的答案。压电材料能够结合机械和电刺激。模拟体内条件的环境被认为是诱导分化过程的最佳条件,但这些机制仍未完全掌握,并且很大程度上依赖于细胞类型。在这张海报中,我们将介绍用于研究物理(即电和/或机械)刺激对人类间充质干细胞影响的实验装置。概述了导致我们的项目的思想过程,以及对电刺激对细胞的影响的简要文献研究。重点将集中在该项目中使用的压电材料。我们选择了一种纳米复合材料,一种带ZnO纳米粒子的共聚物P(VDF-TrFE)基质,以调节基质的机械和压电性能,并提供更好的粘附表面,有利于细胞粘附。
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引用次数: 0
Magnetodielectric properties of (1−x)PMN-PT/xCFO particulate composites (1−x)PMN-PT/xCFO颗粒复合材料的磁介电性能
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297850
F. Zabotto, A. Gualdi, A. D. de Oliveira, J. Eiras, D. Garcia
The magnetic field dependence of the magnetodielectric effect of (1-x)PMN-PT/xCFO particulate composites was systematically investigated. At room temperature, it was found there is a giant magnetodielectric response up to 10% around the electromechanical resonance frequency for a magnetic field of 15kOe. Additionally, at low magnetic fields a positive magnetodielectric coefficient (~2%) associated to the magnetoelectric coupling polarization and dependent of the CFO concentration was observed.
系统地研究了(1-x)PMN-PT/xCFO颗粒复合材料磁介电效应与磁场的关系。在室温下,当磁场为15kOe时,在机电共振频率附近存在高达10%的巨大磁介电响应。此外,在低磁场下,观察到与磁电耦合极化和CFO浓度相关的正磁介电系数(~2%)。
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引用次数: 1
XRD, dielectric and magnetic studies of Cd2Nb2O7 ceramics obtained from mechano-synthesized nanopowders 机械合成纳米粉末制备的Cd2Nb2O7陶瓷的XRD、介电和磁性研究
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297742
M. Połomska, B. Hilczer, Ewa Markiewicz, Zbigniew Trybuła, Bartłomiej Andrzejewski, I. S. Wiza, Adam Pietraszko
Dielectric response, thermal and magnetic properties of hot-pressed ceramics obtained from Cd2Nb2O7 nanopowders synthesized by high-energy milling of CdO and Nb2O5 were studied. The transition from cubic to orthorhombic phase was found to be shifted downwards by ~50 K in comparison with that reported for single crystals. Below 150 K four relaxation processes were revealed and characterized. A broad specific heat anomaly with maximum at 18K, similar to that reported for single crystals was observed. Small magnetic hysteresis loop observed for the ceramics at 4 K can be due to defects introduced in the process of mechanical synthesis.
研究了CdO和Nb2O5高能研磨法制备的Cd2Nb2O7纳米粉体热压陶瓷的介电响应、热性能和磁性能。与单晶相比,发现从立方相到正交相的转变向下移动了~50 K。在150k以下发现并表征了四个弛豫过程。在18K处观察到广泛的比热异常,最大比热异常与单晶相似。在4k时,陶瓷的磁滞回线很小,这可能是由于机械合成过程中引入的缺陷。
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引用次数: 0
Magnetoelectric properties of 0.2CoFe2O4-0.8BaTiO3 composite prepared by organic method 有机法制备0.2CoFe2O4-0.8BaTiO3复合材料的磁电性能
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297820
Morad Etier, Yaling Gao, V. Shvartsman, D. Lupascu, J. Landers, Heiko Wende
We have successfully synthesized CoFe2O4/BaTiO3 composite nanoparticles with core-shell structure using a new organosol crystallization method. The weight fraction of the ferroelectric and the ferrimagnetic phase was 80% and 20%, respectively. The nanopowders were sintered to form a ceramic composite. The ceramics exhibits the magnetoelectric effect. The value of the converse magnetoelectric coefficient αc measured by a modified SQUID susceptometer reaches 4.4·10-12 s·m-1 at the magnetic field μ0Hdc = 0.15 T and T = 285 K.
采用有机溶胶结晶方法,成功合成了具有核壳结构的CoFe2O4/BaTiO3复合纳米颗粒。铁电相和铁磁相的质量分数分别为80%和20%。将纳米粉末烧结形成陶瓷复合材料。陶瓷表现出磁电效应。在μ0Hdc = 0.15 T, T = 285 K时,用改进的SQUID电纳计测得的逆磁电系数αc值可达4.4·10 ~ 12 s·m-1。
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引用次数: 7
Ferroelectric and magnetic phase transitions in multiferroic PbFe0.5Ta0.5O3-PbTiO3 solid solutions 多铁质PbFe0.5Ta0.5O3-PbTiO3固溶体中的铁电相变和磁相变
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297783
A. V. Blazhevich, I. Raevski, S. P. Kubrin, E. Sitalo, S. I. Raevskaya, V. V. Titov, D. Sarychev, M. A. Malitskaya, I. Zakharchenko
Dielectric, X-ray, piezoelectric and Mossbauer studies of highly-resistive Li-doped (1-x)PbFe0.5Ta0.5O3-(x)PbTiO3 ceramics from the 0<; x <;0.3 range fabricated by solid state synthesis and usual sintering have been carried out. Addition of PbTiO3 to PbFe0.5Ta0.5O3 increases the temperature Tm of the permittivity maximum, decreases the diffusion of this maximum and lowers the Neel temperature TN. However above a certain compositional threshold fast lowering of TN stops and a new magnetic state with comparatively high (~50 K) transition temperature becomes stable in a rather wide compositional range.
高阻li掺杂(1-x)PbFe0.5Ta0.5O3-(x)PbTiO3陶瓷从03到PbFe0.5Ta0.5O3的介电、x射线、压电和Mossbauer研究使介电常数最大值的温度Tm升高,最大值的扩散降低,Neel温度TN降低,但在一定的成分阈值以上,TN的快速降低停止,并在相当宽的成分范围内稳定形成较高(~50 K)转变温度的新磁态。
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引用次数: 1
Highly oriented La doped (K, Na)NbO3 ferroelectric thin films 高取向La掺杂(K, Na)NbO3铁电薄膜
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297793
X. Vendrell, L. Mestres, O. Raymond, D. A. Ochoa, J. García
Lead-free (K0.5Na0.5)1-3xLaxNbO3 (x = 0.0-0.005) thin films were synthesized by chemical solution deposition. The X-ray analysis showed that (K0.5Na0.5)NbO3 (KNN) and La doped KNN single-phase thin films were obtained with a [100] preferred orientation. When doping with La, thin films exhibited a remarkably low leakage current and higher dielectric properties.
采用化学溶液沉积法合成了无铅(K0.5Na0.5)1-3xLaxNbO3 (x = 0.0-0.005)薄膜。x射线分析表明,(K0.5Na0.5)NbO3 (KNN)和La掺杂的KNN单相薄膜具有[100]择优取向。当掺杂La时,薄膜表现出非常低的漏电流和更高的介电性能。
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引用次数: 0
Rectifier and structural design for efficient energy harvesting system from impact-based piezoelectric array 冲击式压电阵列高效能量采集系统整流器及结构设计
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297750
K. H. Baek, S. Hong, Se Bin Kim, Jeong Hun Kim, T. Sung
This paper describes an efficient method for piezoelectric energy harvesting (PEH) system from impact forces using an array of piezoelectric modules. Specifically, the rectifier circuit and array configuration are considered. It is shown that rectifying the signal from each piezoelectric module separately generates more energy and charges a capacitor faster than using a single rectifier for all modules connected in series. In addition, the array can be designed such that the modules are impacted simultaneously or sequentially with a phase difference. We show that the latter allows faster energy harvesting. These results could be used in the design of efficient impact-based PEH system.
本文介绍了一种利用压电模块阵列进行冲击能量采集的有效方法。具体地说,整流电路和阵列配置被考虑。结果表明,与使用单个整流器对串联的所有模块进行整流相比,单独整流来自每个压电模块的信号可以产生更多的能量,并更快地为电容器充电。此外,该阵列可以设计成使模块同时或依次受到相位差的影响。我们表明后者可以更快地收集能量。这些结果可用于设计高效的基于冲击的PEH系统。
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引用次数: 2
Synchrotron texture analysis of thick BiFeO3-PbTiO3 layers synthesised by tape casting using Aurivillius and non-Aurivillius templates 用Aurivillius和非Aurivillius模板胶带铸造合成BiFeO3-PbTiO3厚层的同步加速器织构分析
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297816
M. Palizdar, T. Comyn, S. Poterala, G. Messing, E. Suvacı, A. Kleppe, A. J. Jephcoat, A. Bell
The solid solution between bismuth ferrite and lead titanate (xBiFeO3-(1-x)PbTiO3 or BFPT) possesses a morphotropic phase boundary (MPB) between the rhombohedral and tetragonal forms at x=0.7. It is of interest to investigate the influence of field-driven rhombohedral-tetragonal phase transitions across the MPB, to determine whether correctly oriented BFPT can provide both giant piezoelectric properties and significant magnetoelectric coupling. Here, we used the reactive templated grain growth (RTGG) technique to prepare crystallographically textured 0.6BiFeO3-0.4PbTiO3 (60:40 BFPT) ceramics. Both Aurivillius structure templates (Bi4Ti3O12 and PbBi4Ti4O15) and perovskite templates (BaTiO3 and SrTiO3) were used to prepare textured 60:40BFPT. Synchrotron radiation experiments were used to determine the degree of texture. A current data suggests that only BaTiO3 templates survive the sintering process, and other candidate template materials reacted with the 60:40BFPT matrix at high temperature. In the case of SrTiO3, this reaction results in a low Curie temperature (Tc = 350°C) due to the substitution of Sr2+. Aurivillius templates resulted in high Curie temperatures (610°C) and may be chemically suitable if they could be stabilized during the sintering process. However, the resulting ceramics show low remanent polarization (Pr = 3 μc/cm2), while SrTiO3 and BaTiO3 templated ceramics show higher remanent polarizations of 36 and 30 μc/cm2, respectively. Because of their high chemical stability in this system, BaTiO3 templates appear to be the best candidate for fabricating textured BFPT by the TGG method, displaying a high degree of crystallographic texture.
铋铁氧体和钛酸铅(xBiFeO3-(1-x)PbTiO3或BFPT)之间的固溶体在x=0.7时具有介于菱形和四边形之间的相变相边界(MPB)。为了确定正确取向的BFPT能否同时提供巨大的压电性能和显著的磁电耦合,研究场驱动的菱形-四边形相变对MPB的影响是很有意义的。本文采用反应模板晶粒生长(RTGG)技术制备了具有晶体织构的0.6BiFeO3-0.4PbTiO3 (60:40 BFPT)陶瓷。采用Aurivillius结构模板(Bi4Ti3O12和PbBi4Ti4O15)和钙钛矿模板(BaTiO3和SrTiO3)制备了纹理化60:40BFPT。采用同步辐射实验测定织构程度。目前的数据表明,只有BaTiO3模板在烧结过程中幸存下来,其他候选模板材料在高温下与60:40BFPT基体反应。在SrTiO3的情况下,由于Sr2+的取代,该反应导致较低的居里温度(Tc = 350℃)。Aurivillius模板产生高居里温度(610°C),如果在烧结过程中能够稳定,则可能在化学上是合适的。而SrTiO3和BaTiO3模板陶瓷的残余极化率分别为36 μc/cm2和30 μc/cm2,残余极化率较低(Pr = 3 μc/cm2)。由于BaTiO3模板在该体系中具有很高的化学稳定性,因此BaTiO3模板似乎是通过TGG方法制造织构BFPT的最佳候选材料,显示出高度的晶体学织构。
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引用次数: 2
Dielectric properties of grainy composites studied by finite element method 用有限元法研究了颗粒状复合材料的介电性能
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297860
I. Rychetský, A. Klíč
Finite element method together with the spectral representation provide efficient tools for calculation of effective permittivity of 2-component samples. Using this method several samples very studied. It was shown that the grainy samples are well described by the rational functions with few geometric modes, while the samples with strongly irregular clusters are better described by the Lichtenecker-type expressions.
有限元法和谱表示法为计算双组分样品的有效介电常数提供了有效的工具。用这种方法对几个样品进行了研究。结果表明,具有少量几何模态的有理函数可以很好地描述颗粒状样品,而具有强烈不规则簇的样品则可以用lichtenecker型表达式来描述。
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引用次数: 0
Design of vibration exciter by using permanent magnets for application to piezoelectric energy harvesting 用于压电能量收集的永磁体激振器的设计
Pub Date : 2012-07-09 DOI: 10.1109/ISAF.2012.6297748
C. Yang, D. Song, M. S. Woo, S. Hong, K. H. Baek, T. Sung
We designed a piezoelectric energy harvesting system that can shift the resonant frequency to match the fixed external energy frequency. A permanent magnet (10 × 10 × 5 mm3) was attached to the free end of a cantilever beam, and a permanent magnet was attached to each of the four faces of a rotor at 90° angles. The effect of the size of the permanent magnets (40 × 20 × 10 mm3, 30 × 20 × 10 mm3, and 20 × 20 × 10 mm3) and the effect of the pole array distribution (NNNN, SSSS, NSNS, and NNSS) were experimentally investigated. The optimum conditions were determined by testing various distances between the magnets at different rpm's. The experiments showed that the maximum output power was generated for the minimum distance and largest magnet. The most effective approach to adjust the resonance frequency was to change the pole arrays of the magnets attached to the rotor. Furthermore, the optimum conditions were determined at each distance by changing the pole array and rpm. Software simulations support the experimental results.
我们设计了一种压电能量收集系统,该系统可以改变谐振频率以匹配固定的外部能量频率。一个永磁体(10 × 10 × 5 mm3)附着在悬臂梁的自由端,一个永磁体以90°角分别附着在转子的四个面。实验研究了永磁体尺寸(40 × 20 × 10 mm3、30 × 20 × 10 mm3和20 × 20 × 10 mm3)和极阵分布(NNNN、SSSS、NSNS和NNSS)的影响。通过对不同转速下磁体间距的测试,确定了最佳工艺条件。实验表明,磁体尺寸越大,距离越小,输出功率越大。改变转子磁体的磁极排列是调节转子谐振频率最有效的方法。此外,通过改变磁极排列和转速,确定了每个距离下的最佳条件。软件仿真支持实验结果。
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引用次数: 5
期刊
Proceedings of ISAF-ECAPD-PFM 2012
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