Phospholipids that occur predominantly in the plasma membrane of mammalian cells are phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylethanolamine (PE), sphingomyelin (SM), and phosphatidylinositol (or phosphoinositide; PI). These membrane phospholipids are a promising source of disease-related biomarkers. Phospholipids and their metabolites are altered by the type of disease or disease progression. Metabolomics has shown that increased or decreased levels of altered phospholipids and their metabolites can be useful indicators for the diagnosis of various human diseases. In this review, we discuss the utility of the five major membrane phospholipids (PC, PS, PE, and SM, and PI) and their metabolites as diagnostic biomarkers of human diseases.
{"title":"Phospholipids and their metabolites as diagnostic biomarkers of human diseases","authors":"Jeong-Hun Kang , Riki Toita , Takahito Kawano , Masaharu Murata , Arihiro Kano","doi":"10.1016/j.plipres.2025.101340","DOIUrl":"10.1016/j.plipres.2025.101340","url":null,"abstract":"<div><div>Phospholipids that occur predominantly in the plasma membrane of mammalian cells are phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylethanolamine (PE), sphingomyelin (SM), and phosphatidylinositol (or phosphoinositide; PI). These membrane phospholipids are a promising source of disease-related biomarkers. Phospholipids and their metabolites are altered by the type of disease or disease progression. Metabolomics has shown that increased or decreased levels of altered phospholipids and their metabolites can be useful indicators for the diagnosis of various human diseases. In this review, we discuss the utility of the five major membrane phospholipids (PC, PS, PE, and SM, and PI) and their metabolites as diagnostic biomarkers of human diseases.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"99 ","pages":"Article 101340"},"PeriodicalIF":14.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-08DOI: 10.1016/j.plipres.2025.101333
Zheng Yang , Yangyang Chen , Shijie Ma , Meng Zhang , Tong Tang , Chang Du
Long-chain polyunsaturated fatty acids (LC-PUFAs), especially very long-chain polyunsaturated fatty acids (VLC-PUFAs), are highly beneficial to human health including brain development, cardiovascular health and the immune system. Plant-derived edible oils serve as crucial dietary sources of PUFAs for humans. However, oilseed crops such as soybean, peanut, rapeseed, sesame and flax, generally contain insufficient content of LC-PUFAs and do not naturally produce VLC-PUFAs. This review discusses PUFA biosynthesis, current efforts on LC-PUFA bioengineering in oilseed crops, comparing the advantages of different genetic engineering strategies and highlights the bottlenecks encountered in this field. Combination of high-efficient enzymes from various species has enabled the improvement of LC-PUFAs and slight production of VLC-PUFAs, though under risk of generational instability. These and future intelligently designed enzymes with multidisciplinary approaches in molecular biology, biochemistry and plant physiology can be crucial in developing oilseed crops that meet the growing demand for LC-PUFAs.
{"title":"Bioengineering of long-chain polyunsaturated fatty acids in oilseed crops","authors":"Zheng Yang , Yangyang Chen , Shijie Ma , Meng Zhang , Tong Tang , Chang Du","doi":"10.1016/j.plipres.2025.101333","DOIUrl":"10.1016/j.plipres.2025.101333","url":null,"abstract":"<div><div>Long-chain polyunsaturated fatty acids (LC-PUFAs), especially very long-chain polyunsaturated fatty acids (VLC-PUFAs), are highly beneficial to human health including brain development, cardiovascular health and the immune system. Plant-derived edible oils serve as crucial dietary sources of PUFAs for humans. However, oilseed crops such as soybean, peanut, rapeseed, sesame and flax, generally contain insufficient content of LC-PUFAs and do not naturally produce VLC-PUFAs. This review discusses PUFA biosynthesis, current efforts on LC-PUFA bioengineering in oilseed crops, comparing the advantages of different genetic engineering strategies and highlights the bottlenecks encountered in this field. Combination of high-efficient enzymes from various species has enabled the improvement of LC-PUFAs and slight production of VLC-PUFAs, though under risk of generational instability. These and future intelligently designed enzymes with multidisciplinary approaches in molecular biology, biochemistry and plant physiology can be crucial in developing oilseed crops that meet the growing demand for LC-PUFAs.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"99 ","pages":"Article 101333"},"PeriodicalIF":14.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-24DOI: 10.1016/j.plipres.2025.101332
Gonçalo Laureano , Ana Rita Matos , Andreia Figueiredo
Lipids besides being components of membranes and storage molecules are also involved in signalling processes and have proven to be vital components in plant defence mechanisms. Over the past decades, the intricate lipid-signalling pathways that underlie the establishment of defence responses have been extensively studied. These molecules can act directly as signalling agents in plant defence or serve as precursors in a plethora of biosynthetic pathways, leading to the production of phytohormones and other signalling agents. Lipids have proven to be promising elicitors by not only trigger a robust and appropriate defence response, across various plant species, but also induce resistance against a wide range of pathogens. Allied to this, lipids are widespread molecules in nature, which makes them an accessible resource and highlights their potential use as a sustainable approach to crop protection. This comprehensive review emphasizes the potential of lipids and lipid-derived molecules as elicitors in developing sustainable agricultural practices. By leveraging the natural defence mechanisms of plants, lipid elicitors offer a viable and eco-friendly alternative to conventional pest management strategies, contributing to the overall goal of sustainable agriculture.
{"title":"Exploring the potential of lipid elicitors to enhance plant immunity","authors":"Gonçalo Laureano , Ana Rita Matos , Andreia Figueiredo","doi":"10.1016/j.plipres.2025.101332","DOIUrl":"10.1016/j.plipres.2025.101332","url":null,"abstract":"<div><div>Lipids besides being components of membranes and storage molecules are also involved in signalling processes and have proven to be vital components in plant defence mechanisms. Over the past decades, the intricate lipid-signalling pathways that underlie the establishment of defence responses have been extensively studied. These molecules can act directly as signalling agents in plant defence or serve as precursors in a plethora of biosynthetic pathways, leading to the production of phytohormones and other signalling agents. Lipids have proven to be promising elicitors by not only trigger a robust and appropriate defence response, across various plant species, but also induce resistance against a wide range of pathogens. Allied to this, lipids are widespread molecules in nature, which makes them an accessible resource and highlights their potential use as a sustainable approach to crop protection. This comprehensive review emphasizes the potential of lipids and lipid-derived molecules as elicitors in developing sustainable agricultural practices. By leveraging the natural defence mechanisms of plants, lipid elicitors offer a viable and eco-friendly alternative to conventional pest management strategies, contributing to the overall goal of sustainable agriculture.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"98 ","pages":"Article 101332"},"PeriodicalIF":14.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The phospholipase A and acyltransferase (PLAAT) family is a group of structurally related proteins that are conserved among vertebrates. In humans, the family comprises five members (PLAAT1–5), which share common domain structures, and functions as phospholipase A1/A2 and acyltransferase enzymes. Regarding acyltransferase activities, PLAATs produce N-acyl-phosphatidylethanolamines, which serve as the precursor of bioactive N-acylethanolamines (NAEs). Recent evidence strongly suggests that PLAAT proteins play a crucial role in maintaining homeostasis in various organelles, such as the endoplasmic reticulum, lysosomes, mitochondria, and peroxisomes. In this process, PLAAT proteins bind to organelles and degrade them in an enzyme activity-dependent manner. Their physiological significance was revealed by the inability of PLAAT-deficient animals to degrade organelles during the maturation of the eye lens, resulting in the development of cataracts. Furthermore, the deficiency of PLAAT1, 3, and 5 in mice caused resistance to high-fat diet-induced fatty liver, the lean phenotype represented by a marked decrease in adipose tissue mass, and the exacerbation of testicular inflammation due to decreased levels of anti-inflammatory NAEs, respectively. In addition, human PLAAT3 was identified as a causative gene for lipodystrophy. We herein provide an overview of the molecular and biological properties of PLAAT proteins.
{"title":"The PLAAT family as phospholipid-related enzymes","authors":"Toru Uyama, Sumire Sasaki, Mohammad Mamun Sikder, Miki Okada-Iwabu, Natsuo Ueda","doi":"10.1016/j.plipres.2025.101331","DOIUrl":"10.1016/j.plipres.2025.101331","url":null,"abstract":"<div><div>The phospholipase A and acyltransferase (PLAAT) family is a group of structurally related proteins that are conserved among vertebrates. In humans, the family comprises five members (PLAAT1–5), which share common domain structures, and functions as phospholipase A<sub>1</sub>/A<sub>2</sub> and acyltransferase enzymes. Regarding acyltransferase activities, PLAATs produce <em>N</em>-acyl-phosphatidylethanolamines, which serve as the precursor of bioactive <em>N</em>-acylethanolamines (NAEs). Recent evidence strongly suggests that PLAAT proteins play a crucial role in maintaining homeostasis in various organelles, such as the endoplasmic reticulum, lysosomes, mitochondria, and peroxisomes. In this process, PLAAT proteins bind to organelles and degrade them in an enzyme activity-dependent manner. Their physiological significance was revealed by the inability of PLAAT-deficient animals to degrade organelles during the maturation of the eye lens, resulting in the development of cataracts. Furthermore, the deficiency of PLAAT1, 3, and 5 in mice caused resistance to high-fat diet-induced fatty liver, the lean phenotype represented by a marked decrease in adipose tissue mass, and the exacerbation of testicular inflammation due to decreased levels of anti-inflammatory NAEs, respectively. In addition, human PLAAT3 was identified as a causative gene for lipodystrophy. We herein provide an overview of the molecular and biological properties of PLAAT proteins.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"98 ","pages":"Article 101331"},"PeriodicalIF":14.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-04DOI: 10.1016/j.plipres.2025.101330
Xiaoyue Huang , Ahmed Ali , Dounia E.I. Yachioui , Sylvia E. Le Dévédec , Thomas Hankemeier
Triple negative breast cancer (TNBC) has the worst prognosis among breast cancers due to its aggressive nature and the absence of targeted treatments. Development of novel anti-cancer drugs for TNBC faces challenges stemming from its heterogeneity and high potential for metastasis. Metabolomics can be a useful technology in finding novel therapeutic targets and probing the heterogeneity of TNBC. Metabolomics has been enabled by advancements in mass spectrometry (MS)-based platforms that facilitated comprehensive profiling of TNBC metabolism. This review provides an overview of metabolomic changes in TNBC with emphasis on lipid alterations, and describes the key MS analytical techniques, providing the necessary background for examining the role of lipids in TNBC development.
{"title":"Lipid dysregulation in triple negative breast cancer: Insights from mass spectrometry-based approaches","authors":"Xiaoyue Huang , Ahmed Ali , Dounia E.I. Yachioui , Sylvia E. Le Dévédec , Thomas Hankemeier","doi":"10.1016/j.plipres.2025.101330","DOIUrl":"10.1016/j.plipres.2025.101330","url":null,"abstract":"<div><div>Triple negative breast cancer (TNBC) has the worst prognosis among breast cancers due to its aggressive nature and the absence of targeted treatments. Development of novel anti-cancer drugs for TNBC faces challenges stemming from its heterogeneity and high potential for metastasis. Metabolomics can be a useful technology in finding novel therapeutic targets and probing the heterogeneity of TNBC. Metabolomics has been enabled by advancements in mass spectrometry (MS)-based platforms that facilitated comprehensive profiling of TNBC metabolism. This review provides an overview of metabolomic changes in TNBC with emphasis on lipid alterations, and describes the key MS analytical techniques, providing the necessary background for examining the role of lipids in TNBC development.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"98 ","pages":"Article 101330"},"PeriodicalIF":14.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lipid oxidative degradation contributes to the deterioration of food quality and poses potential health risks. A promising approach to counteract this is the use of plant-based antioxidants. However, accurately evaluating the antioxidant capacity and effectiveness of these compounds remains a challenge. While many rapid in vitro tests are available, they must be categorized according to their specific responses to avoid overinterpreting results. This review opens with an overview of current knowledge on lipid autoxidation and recent findings that highlight the challenges in measuring antioxidant capacity. We then examine various methods, addressing their limitations in accurately anticipating outcomes in complex compartmentalized lipid systems. The aim is to clarify the gap between predictions and real-world efficacy in final products. Additionally, the review compares the strengths and weaknesses of methods used to evaluate antioxidant capacity and assess oxidation degrees in complex environments, such as those found in food and cosmetics. Finally, new analytical techniques for multiproduct detection are introduced, paving the way for a more ‘omic’ and spatiotemporally defined approach.
{"title":"Navigating the complexity of lipid oxidation and antioxidation: A review of evaluation methods and emerging approaches","authors":"Erwann Durand , Mickael Laguerre , Claire Bourlieu-Lacanal , Jérôme Lecomte , Pierre Villeneuve","doi":"10.1016/j.plipres.2024.101317","DOIUrl":"10.1016/j.plipres.2024.101317","url":null,"abstract":"<div><div>Lipid oxidative degradation contributes to the deterioration of food quality and poses potential health risks. A promising approach to counteract this is the use of plant-based antioxidants. However, accurately evaluating the antioxidant capacity and effectiveness of these compounds remains a challenge. While many rapid <em>in vitro</em> tests are available, they must be categorized according to their specific responses to avoid overinterpreting results. This review opens with an overview of current knowledge on lipid autoxidation and recent findings that highlight the challenges in measuring antioxidant capacity. We then examine various methods, addressing their limitations in accurately anticipating outcomes in complex compartmentalized lipid systems. The aim is to clarify the gap between predictions and real-world efficacy in final products. Additionally, the review compares the strengths and weaknesses of methods used to evaluate antioxidant capacity and assess oxidation degrees in complex environments, such as those found in food and cosmetics. Finally, new analytical techniques for multiproduct detection are introduced, paving the way for a more ‘omic’ and spatiotemporally defined approach.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101317"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.plipres.2025.101319
Albert Maimó-Barceló , Karim Pérez-Romero , Ramón M. Rodríguez , Cristina Huergo , Ibai Calvo , José A. Fernández , Gwendolyn Barceló-Coblijn
Lipid imaging mass spectrometry (LIMS) allows for establishing the bidimensional distribution of lipid species within a tissue section. One of the main advantages is the generation of spatial information on lipid species distribution at a spatial (lateral) resolution bordering on single-cell resolution with no need to isolate cells. Thus, LIMS images demonstrate, with a level of detail never described before, that lipid profiles are highly sensitive to cell type and pathophysiological state. The wealth and relevance of the information conveyed by LIMS makes up for the lack of a separation stage before sample injection into the mass analyzer, which can somehow be circumvented by other means. Hence, the possibility of describing the lipidome at the cellular level while preserving the microenvironment offers an incomparable opportunity to investigate physiological and pathological contexts. However, to fully grasp the biological implications of the lipid profiles, it is essential to contextualize LIMS data within the broader multiscale ‘omic’ landscape, entailing genomics, epigenomics, and proteomics, each offering a unique window into the regulatory layers of the cell. In this line, the number of techniques that can be combined with LIMS to delve into the molecular mechanisms underlying differential lipid profiles is continuously increasing. Herein, we aim to describe the key features of LIMS analyses, from sample preparation to data interpretation, as well as the current methodologies to enrich and complete the final outcome. While the field is rapidly advancing, we consider there is solid evidence to foresee the incorporation of LIMS into clinical environments.
{"title":"To image or not to image: Use of imaging mass spectrometry in biomedical lipidomics","authors":"Albert Maimó-Barceló , Karim Pérez-Romero , Ramón M. Rodríguez , Cristina Huergo , Ibai Calvo , José A. Fernández , Gwendolyn Barceló-Coblijn","doi":"10.1016/j.plipres.2025.101319","DOIUrl":"10.1016/j.plipres.2025.101319","url":null,"abstract":"<div><div>Lipid imaging mass spectrometry (LIMS) allows for establishing the bidimensional distribution of lipid species within a tissue section. One of the main advantages is the generation of spatial information on lipid species distribution at a spatial (lateral) resolution bordering on single-cell resolution with no need to isolate cells. Thus, LIMS images demonstrate, with a level of detail never described before, that lipid profiles are highly sensitive to cell type and pathophysiological state. The wealth and relevance of the information conveyed by LIMS makes up for the lack of a separation stage before sample injection into the mass analyzer, which can somehow be circumvented by other means. Hence, the possibility of describing the lipidome at the cellular level while preserving the microenvironment offers an incomparable opportunity to investigate physiological and pathological contexts. However, to fully grasp the biological implications of the lipid profiles, it is essential to contextualize LIMS data within the broader multiscale ‘omic’ landscape, entailing genomics, epigenomics, and proteomics, each offering a unique window into the regulatory layers of the cell. In this line, the number of techniques that can be combined with LIMS to delve into the molecular mechanisms underlying differential lipid profiles is continuously increasing. Herein, we aim to describe the key features of LIMS analyses, from sample preparation to data interpretation, as well as the current methodologies to enrich and complete the final outcome. While the field is rapidly advancing, we consider there is solid evidence to foresee the incorporation of LIMS into clinical environments.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101319"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.plipres.2024.101318
Sepideh Alijani , Andreas Hahn , William S. Harris , Jan Philipp Schuchardt
The bioavailability of long-chain omega-3 fatty acids is a critical yet often overlooked factor influencing their efficacy. This review evaluates the bioavailability of EPA/DHA from acute (single-dose) and chronic human studies, focusing on (a) chemical forms such as triacylglycerols (TAG, natural and re-esterified, rTAG), non-esterified fatty acids (NEFA), and phospholipids (PL) from sources like fish, krill, and microalgae, and (b) delivery methods like microencapsulation and emulsification. Bioavailability for isolated chemically forms followed the order: NEFA > PL > rTAG > unmodified TAG > ethyl esters (EE). However, varying oil compositions complicate conclusions about source-specific bioavailability. Significant differences observed in acute bioavailability studies (e.g., faster absorption) often did not translate into long-term impacts in chronic supplementation studies. This raises questions about the clinical relevance of acute findings, especially given that n-3 PUFA supplements are typically consumed long-term. Methodological limitations, such as inappropriate biomarkers, short sampling windows, and inadequate product characterization, hinder the reliability and comparability of studies. The review emphasizes the need for standardized protocols and robust chronic studies to clarify the clinical implications of bioavailability differences. Future research should prioritize biomarkers that reflect sustained n-3 PUFA status to better understand the health benefits of various EPA and DHA formulations.
{"title":"Bioavailability of EPA and DHA in humans – A comprehensive review","authors":"Sepideh Alijani , Andreas Hahn , William S. Harris , Jan Philipp Schuchardt","doi":"10.1016/j.plipres.2024.101318","DOIUrl":"10.1016/j.plipres.2024.101318","url":null,"abstract":"<div><div>The bioavailability of long-chain omega-3 fatty acids is a critical yet often overlooked factor influencing their efficacy. This review evaluates the bioavailability of EPA/DHA from acute (single-dose) and chronic human studies, focusing on (a) chemical forms such as triacylglycerols (TAG, natural and re-esterified, rTAG), non-esterified fatty acids (NEFA), and phospholipids (PL) from sources like fish, krill, and microalgae, and (b) delivery methods like microencapsulation and emulsification. Bioavailability for isolated chemically forms followed the order: NEFA > PL > rTAG > unmodified TAG > ethyl esters (EE). However, varying oil compositions complicate conclusions about source-specific bioavailability. Significant differences observed in acute bioavailability studies (e.g., faster absorption) often did not translate into long-term impacts in chronic supplementation studies. This raises questions about the clinical relevance of acute findings, especially given that n-3 PUFA supplements are typically consumed long-term. Methodological limitations, such as inappropriate biomarkers, short sampling windows, and inadequate product characterization, hinder the reliability and comparability of studies. The review emphasizes the need for standardized protocols and robust chronic studies to clarify the clinical implications of bioavailability differences. Future research should prioritize biomarkers that reflect sustained n-3 PUFA status to better understand the health benefits of various EPA and DHA formulations.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101318"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.plipres.2025.101320
Sarah Salomon, Océane Oliva, Alberto Amato, Olivier Bastien, Morgane Michaud, Juliette Jouhet
Betaine lipids (BL) are relatively understudied non‑phosphorus glycerolipids. They are predominantly found in algae but have also been detected in other unicellular eukaryotes, fungi, bacteria, and some bryophytes and pteridophytes. These extraplastidial lipids are considered as substitute for phospholipids in organisms, particularly under phosphate (Pi) deficiency. This review provides a broader perspective on the roles and functions of BL, revealing their functional diversity across species and environments. It also discuss the biosynthetic pathways of BL. Indeed, the pathway for DGTS (1(3),2-diacylglyceryl-3(1)-O-4′-(N,N,N-trimethyl)-homoserine), the most widespread and studied BL form, is completely known, whereas the pathway for DGTA (1(3),2-diacylglyceryl-3(1)-O-2′-(N,N,N-trimethyl)-β-alanine) is only partially understood. In this review, the role of the BTA1 gene, responsible for the synthesis of DGTS, is discussed. It is revealed to be essential in DGTA synthesis as it enables the production of its intermediate, DGTS. A phylogenetic analysis, conducted on BTA1 gene, does not seem to link the phylogenetic position of BTA1 with the BL species produced but confirms the distribution trends, with a BL diversification in marine environments and the gradual disappearance of DGTS in the evolution of the green lineage. Further research is needed to elucidate the specific roles and biosynthetic pathways of BL across different species.
甜菜碱脂（BL）是研究相对较少的非磷甘油脂。它们主要存在于藻类中，但也存在于其他单细胞真核生物、真菌、细菌和一些苔藓植物和蕨类植物中。这些胞外脂质被认为是生物体中磷脂的替代品，特别是在磷酸盐（Pi）缺乏的情况下。本文综述了BL在不同物种和环境中的作用和功能，揭示了它们的功能多样性。它还讨论了BL的生物合成途径。事实上，DGTS(1(3)，2-二酰基甘油-3（1)- o -4'-（N，N，N-三甲基）-纯丝氨酸）的途径是完全已知的，而DGTA(1(3)，2-二酰基甘油-3（1)- o -2'-（N，N，N-三甲基）-β-丙氨酸）的途径只是部分了解。本文就BTA1基因在DGTS合成中的作用作一综述。它在DGTA合成中是必不可少的，因为它使其中间体DGTS的生产成为可能。通过对BTA1基因的系统发育分析，BTA1基因的系统发育位置似乎与产生的BL物种没有联系，但证实了其分布趋势，即在海洋环境中BL多样化，而在绿色谱系的进化过程中DGTS逐渐消失。不同物种间BL的具体作用和生物合成途径有待进一步研究。
{"title":"Betaine lipids: Biosynthesis, functional diversity and evolutionary perspectives","authors":"Sarah Salomon, Océane Oliva, Alberto Amato, Olivier Bastien, Morgane Michaud, Juliette Jouhet","doi":"10.1016/j.plipres.2025.101320","DOIUrl":"10.1016/j.plipres.2025.101320","url":null,"abstract":"<div><div>Betaine lipids (BL) are relatively understudied non‑phosphorus glycerolipids. They are predominantly found in algae but have also been detected in other unicellular eukaryotes, fungi, bacteria, and some bryophytes and pteridophytes. These extraplastidial lipids are considered as substitute for phospholipids in organisms, particularly under phosphate (Pi) deficiency. This review provides a broader perspective on the roles and functions of BL, revealing their functional diversity across species and environments. It also discuss the biosynthetic pathways of BL. Indeed, the pathway for DGTS (1(3),2-diacylglyceryl-3(1)-<em>O</em>-4′-(<em>N,N,N</em>-trimethyl)-homoserine), the most widespread and studied BL form, is completely known, whereas the pathway for DGTA (1(3),2-diacylglyceryl-3(1)-<em>O</em>-2′-(<em>N,N,N</em>-trimethyl)-β-alanine) is only partially understood. In this review, the role of the <em>BTA1</em> gene, responsible for the synthesis of DGTS, is discussed. It is revealed to be essential in DGTA synthesis as it enables the production of its intermediate, DGTS. A phylogenetic analysis, conducted on <em>BTA1</em> gene, does not seem to link the phylogenetic position of <em>BTA1</em> with the BL species produced but confirms the distribution trends, with a BL diversification in marine environments and the gradual disappearance of DGTS in the evolution of the green lineage. Further research is needed to elucidate the specific roles and biosynthetic pathways of BL across different species.</div></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"97 ","pages":"Article 101320"},"PeriodicalIF":14.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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