Epilepsy is a chronic disorder of the brain that affect people worldwide. Nearly about 50-80% of the patients with epilepsy are controlled with currently available antiepileptic drugs. But these drugs cannot able to control seizures effectively in about 10-20% of the patients. The treatment of epilepsy still remains inadequate even though new anticonvulsants are being developed. The present study was undertaken to investigate effect of J.regia in management of seizures.100 mg fruit extract was administered in seperate groups of animal. The J.regia fruit extract shows the anticonvulsant activity in animal model.
{"title":"In-vivo Evaluation of Anticonvulsant activity of Juglans regia fruit extract","authors":"Samruddhi Satish Vyawahare, Rajesh Mandade, Pranay Uplenchwar","doi":"10.52711/2321-5836.2023.00028","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00028","url":null,"abstract":"Epilepsy is a chronic disorder of the brain that affect people worldwide. Nearly about 50-80% of the patients with epilepsy are controlled with currently available antiepileptic drugs. But these drugs cannot able to control seizures effectively in about 10-20% of the patients. The treatment of epilepsy still remains inadequate even though new anticonvulsants are being developed. The present study was undertaken to investigate effect of J.regia in management of seizures.100 mg fruit extract was administered in seperate groups of animal. The J.regia fruit extract shows the anticonvulsant activity in animal model.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139282048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-09DOI: 10.52711/2321-5836.2023.00036
Aditya Mathur, S. Asthana, Samir Patra, Pulak Jana
Almost 90% of cases of diabetes in adult is type 2 diabetes mellitus (T2DM). It is a chronic metabolic disorder happens for insulin resistance that cause chronic hyperglycaemia. This review article based on search on medicine, database of systemic reviews. This review presenting the etiology and major factors involved in development of type 2 diabetes mellitus and also the modification of lifestyle which is useful in the management of T2DM. Screening and diagnosis is based on the World Health Organization (WHO) and American Diabetes Association (ADA) criteria. Glucolipotoxicity, if left untreated it reduce function of pancreatic beta cell. Various environmental factors and genetic factors cause onset action of increase in diabetes. Treatment include lifestyle modification, obesity maintaining, oral hypoglycaemic agents and insulin sensitizer like metformin, biguanide decrease resistance of insulin and other is sulfonylureas thiazolidinediones, alpha- glucosidase inhibitor. It also includes the explanation of current strategies to control diabetes. The employment of phytoconstituent as multitargeting molecules and their potential use with a first line drug that helps to reduce the side effects which is caused by synthetic drugs are also explained.
{"title":"A Review on Current Type-2 Diabetes Mellitus Treatment by selected Phytoconstituents","authors":"Aditya Mathur, S. Asthana, Samir Patra, Pulak Jana","doi":"10.52711/2321-5836.2023.00036","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00036","url":null,"abstract":"Almost 90% of cases of diabetes in adult is type 2 diabetes mellitus (T2DM). It is a chronic metabolic disorder happens for insulin resistance that cause chronic hyperglycaemia. This review article based on search on medicine, database of systemic reviews. This review presenting the etiology and major factors involved in development of type 2 diabetes mellitus and also the modification of lifestyle which is useful in the management of T2DM. Screening and diagnosis is based on the World Health Organization (WHO) and American Diabetes Association (ADA) criteria. Glucolipotoxicity, if left untreated it reduce function of pancreatic beta cell. Various environmental factors and genetic factors cause onset action of increase in diabetes. Treatment include lifestyle modification, obesity maintaining, oral hypoglycaemic agents and insulin sensitizer like metformin, biguanide decrease resistance of insulin and other is sulfonylureas thiazolidinediones, alpha- glucosidase inhibitor. It also includes the explanation of current strategies to control diabetes. The employment of phytoconstituent as multitargeting molecules and their potential use with a first line drug that helps to reduce the side effects which is caused by synthetic drugs are also explained.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"192 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.52711/2321-5836.2023.00019
O. Sreenivasa Krishna, S. Naveen Kumar, K. Vijay Kumar, Rajeswari C., Akhil CH.
Phytochemicals are known to contain a high concentration of therapeutically active principles, which, when consumed in sufficient quantities, can have drug-like effects. Bryophillum pinnatum (Lam.) is a succulent-ethno medicinal xerophyte with a long history of use in traditional Indian medicine. Because reactive oxygen species are the most common etiological factor in many degenerative diseases, controlling them with antioxidants may both treat and prevent disease progression. The current study will look at the ability of fresh leaf juice of Bryophillum pinnatum (Lam.) (FLJBP) to prevent oxidative injury and subsequent hemolysis in goat erythrocytes as a model test system. The catalytic activity of membrane bound enzymes like sodium potassium-ATPase, Ach-Ease, and metabolic enzymes like hexokinase, as well as the NO concentration in goat RBCs, were measured. Phenyl hydrazine was used first, followed by FLJBP at concentrations of 20, 40, 60, 80, and 100g/ml. A dose-dependent (PHZ) increase in Pi liberation by hexokinase and Na+/K+ ATPase, as well as increased formation of thiocholine iodide and enhanced NO scavenging potential, has indicated that flip has good anti-oxidant and anti-haemolytic activity. To record the functional food status of Bryophillum pinnatum (Lam.) species, a more rigorous and stringent battery of pharmacological, phytochemical, and bio analytical studies, followed by observational studies in humans, will be conducted.
{"title":"Evaluation of In-vitro Antioxidant Potential of Bryophillum pinnatum Leaf Juice in Phenyl Hydrazine Treated Goat Erythrocytes","authors":"O. Sreenivasa Krishna, S. Naveen Kumar, K. Vijay Kumar, Rajeswari C., Akhil CH.","doi":"10.52711/2321-5836.2023.00019","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00019","url":null,"abstract":"Phytochemicals are known to contain a high concentration of therapeutically active principles, which, when consumed in sufficient quantities, can have drug-like effects. Bryophillum pinnatum (Lam.) is a succulent-ethno medicinal xerophyte with a long history of use in traditional Indian medicine. Because reactive oxygen species are the most common etiological factor in many degenerative diseases, controlling them with antioxidants may both treat and prevent disease progression. The current study will look at the ability of fresh leaf juice of Bryophillum pinnatum (Lam.) (FLJBP) to prevent oxidative injury and subsequent hemolysis in goat erythrocytes as a model test system. The catalytic activity of membrane bound enzymes like sodium potassium-ATPase, Ach-Ease, and metabolic enzymes like hexokinase, as well as the NO concentration in goat RBCs, were measured. Phenyl hydrazine was used first, followed by FLJBP at concentrations of 20, 40, 60, 80, and 100g/ml. A dose-dependent (PHZ) increase in Pi liberation by hexokinase and Na+/K+ ATPase, as well as increased formation of thiocholine iodide and enhanced NO scavenging potential, has indicated that flip has good anti-oxidant and anti-haemolytic activity. To record the functional food status of Bryophillum pinnatum (Lam.) species, a more rigorous and stringent battery of pharmacological, phytochemical, and bio analytical studies, followed by observational studies in humans, will be conducted.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Medication safety during administration is a major concern at a global level. Nurses are responsible for administration of HAMs, as incorrect administration can have a significant clinical outcome. The aim of the study was to determine the effectiveness of web quest on high alert medications among nursing students. Methods and Materials: A true experimental research was conducted at Apollo College of Nursing, Chennai, among 100 nursing students selected by total enumerative sampling technique and randomized to control and experimental group (50 in each group) by odd and even method. After obtaining the setting permission and informed consent from participants, data was collected using pretested and validated tools such as background variables proforma of nursing students and multiple choice questionnaire on high alert through Google forms in what’s app and e- mails. The data regarding background variables and pre-test assessment of knowledge on high alert medicationswas obtainedon day 1. Then post test was conducted for the control group on day 3.On day 4, web-quest on high alert medicationswas implemented for the experimental group. On day 5 post-test assessment was conducted for the experimental group. The collected data were analysed using descriptive and inferential statistics. Results: There was a significant difference in post-test mean knowledge scores on high alert medications between control (10.86±4.73) and experiment group (18.97±2.17) of nursing students (t=10.29 at p < 0.001). Conclusion: The present study reveals that web quest is considered as a suitable method to improve the level of knowledge among nursing students.
{"title":"Effectiveness of Web Quest on High Alert Medications upon Knowledge among Nursing Students, Chennai","authors":"Manju Sudhakar, Sasikala Dhakshinamoorthy, Jaslina Gnanarani, Nesa Sathya Satchi","doi":"10.52711/2321-5836.2023.00018","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00018","url":null,"abstract":"Background: Medication safety during administration is a major concern at a global level. Nurses are responsible for administration of HAMs, as incorrect administration can have a significant clinical outcome. The aim of the study was to determine the effectiveness of web quest on high alert medications among nursing students. Methods and Materials: A true experimental research was conducted at Apollo College of Nursing, Chennai, among 100 nursing students selected by total enumerative sampling technique and randomized to control and experimental group (50 in each group) by odd and even method. After obtaining the setting permission and informed consent from participants, data was collected using pretested and validated tools such as background variables proforma of nursing students and multiple choice questionnaire on high alert through Google forms in what’s app and e- mails. The data regarding background variables and pre-test assessment of knowledge on high alert medicationswas obtainedon day 1. Then post test was conducted for the control group on day 3.On day 4, web-quest on high alert medicationswas implemented for the experimental group. On day 5 post-test assessment was conducted for the experimental group. The collected data were analysed using descriptive and inferential statistics. Results: There was a significant difference in post-test mean knowledge scores on high alert medications between control (10.86±4.73) and experiment group (18.97±2.17) of nursing students (t=10.29 at p < 0.001). Conclusion: The present study reveals that web quest is considered as a suitable method to improve the level of knowledge among nursing students.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Pyrazole nucleus in general and its chemistry has found much more attention during the last few decades because of out-standing biological activities. It acts as Antipyretic, analgesic, anti-inflammatory, kinase inhibitors, and as insecticides. It has good properties as antibacterial, antifungal, and an antiparasitics, as well, considering all those benefits and in continues of our work to synthesize new hetero starting from 1,3-diphenyl-4-carboxaaldehyde, we introduce here in several new pharmacophores, such as pyrimidine, pyramidinethoine and thiazole moieties onto the pyarazole nucleus to obtain compounds with enhanced potency.
{"title":"Research on Synthesis and Pharmacological Evaluation of Subsituated Chalcone deriatives for Antimicrobial and Antifungal activity","authors":"Snehal Dilip Kothavale, Guruprasad Vinayak Borgaonkar, S.K. Mohite, S.R. Kane, Savita Satpute","doi":"10.52711/2321-5836.2023.00020","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00020","url":null,"abstract":"The Pyrazole nucleus in general and its chemistry has found much more attention during the last few decades because of out-standing biological activities. It acts as Antipyretic, analgesic, anti-inflammatory, kinase inhibitors, and as insecticides. It has good properties as antibacterial, antifungal, and an antiparasitics, as well, considering all those benefits and in continues of our work to synthesize new hetero starting from 1,3-diphenyl-4-carboxaaldehyde, we introduce here in several new pharmacophores, such as pyrimidine, pyramidinethoine and thiazole moieties onto the pyarazole nucleus to obtain compounds with enhanced potency.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.52711/2321-5836.2023.00026
Swapnil S. Lad, Swati U. Kolhe, Omkar A. Devade, Chetashri N. Patil, Rohit D. Nalawade, Manthan R. Rode
Colocasia esculenta Linn. is one of the widely available plant all over the globe with history of use in Indian traditional system. Colocasia esculenta Linn. has attained popularity across the globe to replace synthetic medicines due to their less side effects and its natural plant origin. It is commonly known as taro belonging to family Araceae. It is used as a vegetable for many nutritional as well as medicinal purposes. The two important therapeutically active chemical constituents are present in taro leaf extract namely flavonoids and triterpenoids. The pharmacological studies of Colocasia esculenta Linn. estimated that the herb showed various pharmacological activities, including nervine tonic, antioxidant, anti-inflammatory, anti-lipid peroxidative activity, hepatoprotective, antifungal, antidiabetic, anticancer and antimicrobial effects. This review is designed to give exhaustive account on taxonomy, geographical and nutritional information, various phytochemical constituents and pharmacologic activities of taro.
{"title":"A Review on Medicinal properties of Colocasia esculenta Linn","authors":"Swapnil S. Lad, Swati U. Kolhe, Omkar A. Devade, Chetashri N. Patil, Rohit D. Nalawade, Manthan R. Rode","doi":"10.52711/2321-5836.2023.00026","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00026","url":null,"abstract":"Colocasia esculenta Linn. is one of the widely available plant all over the globe with history of use in Indian traditional system. Colocasia esculenta Linn. has attained popularity across the globe to replace synthetic medicines due to their less side effects and its natural plant origin. It is commonly known as taro belonging to family Araceae. It is used as a vegetable for many nutritional as well as medicinal purposes. The two important therapeutically active chemical constituents are present in taro leaf extract namely flavonoids and triterpenoids. The pharmacological studies of Colocasia esculenta Linn. estimated that the herb showed various pharmacological activities, including nervine tonic, antioxidant, anti-inflammatory, anti-lipid peroxidative activity, hepatoprotective, antifungal, antidiabetic, anticancer and antimicrobial effects. This review is designed to give exhaustive account on taxonomy, geographical and nutritional information, various phytochemical constituents and pharmacologic activities of taro.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135840479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In Ayurveda Cinamon has been used for the treatment of various illness like trusna (thirst), Kantha roga (diseases of throat), mukha roga (diseases of mouth), Pinasa (nasaroga), Krumiroga (healmenth) Vastiroga (disease of bladder), Arsa (piles) and Hrudroga (Heart disease). Cinnamon is a common spice used by different societies around the world for several centuries. It is obtained from the inner bark of trees from the genus Cinnamomum, a tropical evergreen plant. The medicinal uses of spices were often indistinguishable from their culinary uses. The value of phytochemicals in relation to human health has been recognized for centuries. The constituents of herbs and spices can have overlapping actions, including reduction of inflammation, antioxidant effects, modulation of detoxification enzymes, modulation of the immune system, and antibacterial and antiviral effects. Therapeutically cinnamon has anti-diabetic, antioxidant, anti-clotting, anti-inflammatory, carminative, and rubefacient properties. The most important constituents of cinnamon are cinnamaldehyde and trans-cinnamaldehyde (Cin), present in the essential oil. It is an ingredient of Trijataka and Chaturjataka and Sitopaladi Churna and Talisadi Churna mentioned in different classical text of Ayurveda.
{"title":"Uses of Twak (Cinnamon) In Ayurveda with pharmacological evidence - A Review","authors":"Purnendu Panda, Indu. S, Banamali Das, Krishna Rao.S, M.M. Rao","doi":"10.52711/2321-5836.2023.00025","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00025","url":null,"abstract":"In Ayurveda Cinamon has been used for the treatment of various illness like trusna (thirst), Kantha roga (diseases of throat), mukha roga (diseases of mouth), Pinasa (nasaroga), Krumiroga (healmenth) Vastiroga (disease of bladder), Arsa (piles) and Hrudroga (Heart disease). Cinnamon is a common spice used by different societies around the world for several centuries. It is obtained from the inner bark of trees from the genus Cinnamomum, a tropical evergreen plant. The medicinal uses of spices were often indistinguishable from their culinary uses. The value of phytochemicals in relation to human health has been recognized for centuries. The constituents of herbs and spices can have overlapping actions, including reduction of inflammation, antioxidant effects, modulation of detoxification enzymes, modulation of the immune system, and antibacterial and antiviral effects. Therapeutically cinnamon has anti-diabetic, antioxidant, anti-clotting, anti-inflammatory, carminative, and rubefacient properties. The most important constituents of cinnamon are cinnamaldehyde and trans-cinnamaldehyde (Cin), present in the essential oil. It is an ingredient of Trijataka and Chaturjataka and Sitopaladi Churna and Talisadi Churna mentioned in different classical text of Ayurveda.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.52711/2321-5836.2023.00023
Swapnil S. Lad, Swati U. Kolhe, Omkar A. Devade, Chetashri N. Patil, Rohit D. Nalawade, Asawari P. Mansabdar
Since the beginning of time people have used plants as a solution for different infections and/or diseases. With the approach of current synthetic medicines, plant medication has frequently been subjected to the edge of therapeutic modalities. However, it is progressively being recognized that the synthetic therapeutic agents have a few limitations particularly in ongoing chronic illnesses like hyperlipidaemia. Hyperlipidaemia is an ailment characterised by an expansion in at least one of the plasma lipids, including cholesterol, triglycerides, plasma lipoproteins such as low density lipoprotein (LDL) and very low density lipoprotein (VLDL) alongside diminished high-density lipoprotein (HDL) levels. Research is continuous to find more current medications and a few novel helpful targets are being investigated for hyperlipidaemia. In the current review, the types of hyperlipidaemia, lipid metabolism, causes and risk factors of hyperlipidaemia has been explained alongsidethe plant derived bioactiveand extracts that have been demonstrated in the past 15 years to have a potential in treatment of hyperlipidaemia has been discussed.
{"title":"Hyperlipidaemia: A Review of Literature","authors":"Swapnil S. Lad, Swati U. Kolhe, Omkar A. Devade, Chetashri N. Patil, Rohit D. Nalawade, Asawari P. Mansabdar","doi":"10.52711/2321-5836.2023.00023","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00023","url":null,"abstract":"Since the beginning of time people have used plants as a solution for different infections and/or diseases. With the approach of current synthetic medicines, plant medication has frequently been subjected to the edge of therapeutic modalities. However, it is progressively being recognized that the synthetic therapeutic agents have a few limitations particularly in ongoing chronic illnesses like hyperlipidaemia. Hyperlipidaemia is an ailment characterised by an expansion in at least one of the plasma lipids, including cholesterol, triglycerides, plasma lipoproteins such as low density lipoprotein (LDL) and very low density lipoprotein (VLDL) alongside diminished high-density lipoprotein (HDL) levels. Research is continuous to find more current medications and a few novel helpful targets are being investigated for hyperlipidaemia. In the current review, the types of hyperlipidaemia, lipid metabolism, causes and risk factors of hyperlipidaemia has been explained alongsidethe plant derived bioactiveand extracts that have been demonstrated in the past 15 years to have a potential in treatment of hyperlipidaemia has been discussed.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135840478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.52711/2321-5836.2023.00021
Mayuri K. Gaikwad, Mohini Upadhye, Dhanashri Borchate, Nilam Jankar
Sanitary items include hazardous chemicals that could cause dangerous issues in the future. In this article, emphasis is placed on how sanitary goods containing dangerous chemicals damage the reproductive system and cause a variety of issues, including infertility, ovarian cancer, skin rashes, and skin darkening. unbalanced menstrual cycle. Numerous compounds, including dioxin, voc, furans, phthalates, bisphenols, and others, are included in sanitary goods. Similar safety measures that must be implemented have also been discussed.
{"title":"Impact of Hazardous Chemical compounds on Reproductive System Reported in Sanitary Products","authors":"Mayuri K. Gaikwad, Mohini Upadhye, Dhanashri Borchate, Nilam Jankar","doi":"10.52711/2321-5836.2023.00021","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00021","url":null,"abstract":"Sanitary items include hazardous chemicals that could cause dangerous issues in the future. In this article, emphasis is placed on how sanitary goods containing dangerous chemicals damage the reproductive system and cause a variety of issues, including infertility, ovarian cancer, skin rashes, and skin darkening. unbalanced menstrual cycle. Numerous compounds, including dioxin, voc, furans, phthalates, bisphenols, and others, are included in sanitary goods. Similar safety measures that must be implemented have also been discussed.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-alcoholic fatty liver disease (NAFLD) is a serious health issue globally. It includes a broad spectrum of alteration from simple steatosis to steatohepatitis and cirrhosis. Obesity and type-2 diabetes mellitus (T2DM) are the major factors that are associated with progression of NAFLD. The disease has been proven to have a higher incidence of hepatic and cardiovascular complications. The aetiopathogenesis is still unclear; however some of many pathophysiological mechanisms that are involved in the development of NAFLD include fatty-acid accumulation in hepatic parenchyma, impaired mitochondrial metabolism, inflammation, oxidative stress, oxygen free radicals. Liver biopsy is the diagnostic gold-standard for NAFLD, but multiple non-invasive techniques like serological biomarkers and radiological techniques have established a new field for research. Since several inter-related pathways are involved in the pathological process, a single therapeutic agent is not helpful. Therefore, a combination therapy towards multiple targets could control the NAFLD. Various new targeted therapies includes apoptosis signal regulating kinase-1(ASK1) inhibitor, FXR (Farnesoid X receptor)-agonists, Caspase Inhibition, SCD-1(Stearoyl coenzyme A desaturase -1) enzyme inhibitors, SIRT1 (Sirtuin1) activator, CCR2 (chemokine receptor 2) and CCR5 (chemokine receptor 5) inhibitors, DPP-4 (Dipeptidyl peptidase-4) inhibitors and NOX (NADPH oxidase)-1/4 inhibitors that are currently under investigation. The treatment for patients with NAFLD is mainly based on loss of body weight and adjuvant management by using insulin sensitizer, anti-oxidants and reducing inflammation. The development of a healthy lifestyle and moderate exercise may be pillars for the treatment of NAFLD.
{"title":"Non-Alcoholic Fatty Liver Disease (NAFLD) and its Recent Therapeutic Strategies","authors":"Nikunja Kishor Mishra, Amiyakanta Mishra, Rosy Priyadarshini","doi":"10.52711/2321-5836.2023.00022","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00022","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a serious health issue globally. It includes a broad spectrum of alteration from simple steatosis to steatohepatitis and cirrhosis. Obesity and type-2 diabetes mellitus (T2DM) are the major factors that are associated with progression of NAFLD. The disease has been proven to have a higher incidence of hepatic and cardiovascular complications. The aetiopathogenesis is still unclear; however some of many pathophysiological mechanisms that are involved in the development of NAFLD include fatty-acid accumulation in hepatic parenchyma, impaired mitochondrial metabolism, inflammation, oxidative stress, oxygen free radicals. Liver biopsy is the diagnostic gold-standard for NAFLD, but multiple non-invasive techniques like serological biomarkers and radiological techniques have established a new field for research. Since several inter-related pathways are involved in the pathological process, a single therapeutic agent is not helpful. Therefore, a combination therapy towards multiple targets could control the NAFLD. Various new targeted therapies includes apoptosis signal regulating kinase-1(ASK1) inhibitor, FXR (Farnesoid X receptor)-agonists, Caspase Inhibition, SCD-1(Stearoyl coenzyme A desaturase -1) enzyme inhibitors, SIRT1 (Sirtuin1) activator, CCR2 (chemokine receptor 2) and CCR5 (chemokine receptor 5) inhibitors, DPP-4 (Dipeptidyl peptidase-4) inhibitors and NOX (NADPH oxidase)-1/4 inhibitors that are currently under investigation. The treatment for patients with NAFLD is mainly based on loss of body weight and adjuvant management by using insulin sensitizer, anti-oxidants and reducing inflammation. The development of a healthy lifestyle and moderate exercise may be pillars for the treatment of NAFLD.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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