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Industry updates from the field of stem cell research and regenerative medicine in June 2023. 2023年6月,干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-01 Epub Date: 2023-08-09 DOI: 10.2217/rme-2023-0152
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in June 2023.

2023年6月,根据非学术机构的公开信息和新闻稿汇编了干细胞研究和再生医学领域的最新进展。
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引用次数: 0
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases. 间充质干细胞衍生的条件培养基/分泌组作为眼部疾病治疗选择的潜力。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI: 10.2217/rme-2023-0089
Wesley Harrisson Bouche Djatche, Huimin Zhu, Wenlei Ma, Yue Li, Ziang Li, Hong Zhao, Zhizhen Liu, Hua Qiao

Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential therapeutic use of MSC-CM in eye conditions, such as corneal diseases, dry eye, glaucoma, retinal diseases and uveitis. We discuss the current evidence, some limitations, and the progress that remains to be achieved before clinical translation becomes possible.

研究表明,间充质干细胞(MSC)的治疗效果部分是由于其分泌因子,而不是将细胞植入治疗过的组织或组织替代物中。MSC分泌组,特别是以条件培养基(MSC-CM)的形式,目前正在被探索作为MSC移植的替代品。尽管观察到MSC-CM的益处,但只有少数临床试验评估了它和其他分泌组分在治疗眼病中的作用。这篇综述深入了解了MSC-CM在角膜疾病、干眼症、青光眼、视网膜疾病和葡萄膜炎等眼部疾病中的潜在治疗用途。我们讨论了目前的证据、一些局限性,以及在临床翻译成为可能之前有待取得的进展。
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引用次数: 0
Modeling new trends in bone regeneration, using the BERTopic approach. 利用BERTopic方法对骨再生的新趋势进行建模。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0096
Stefano Guizzardi, Maria Teresa Colangelo, Prisco Mirandola, Carlo Galli

Aim: Bibliometric surveys are time-consuming endeavors, which cannot be scaled up to meet the challenges of ever-expanding fields, such as bone regeneration. Artificial intelligence, however, can provide smart tools to screen massive amounts of literature, and we relied on this technology to automatically identify research topics. Materials & methods: We used the BERTopic algorithm to detect the topics in a corpus of MEDLINE manuscripts, mapping their similarities and highlighting research hotspots. Results: Using BERTopic, we identified 372 topics and were able to assess the growing importance of innovative and recent fields of investigation such as 3D printing and extracellular vescicles. Conclusion: BERTopic appears as a suitable tool to set up automatic screening routines to track the progress in bone regeneration.

目的:文献计量学调查是一项耗时的工作,它不能扩大规模以满足不断扩大的领域的挑战,例如骨再生。然而,人工智能可以提供智能工具来筛选大量文献,我们依靠这项技术来自动识别研究主题。材料与方法:我们使用BERTopic算法检测MEDLINE手稿语料库中的主题,绘制其相似度并突出研究热点。结果:使用BERTopic,我们确定了372个主题,并能够评估创新和最新研究领域(如3D打印和细胞外囊泡)日益增长的重要性。结论:BERTopic是建立自动筛选程序以跟踪骨再生进展的合适工具。
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引用次数: 0
Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice. 脐血单核细胞阴囊移植对老年小鼠性功能的影响。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2022-0191
Jun Li, Yinghong Jiang, Wei Xue, Lejiang Liu, Hua Yu, Xuemei Zhang, Xiao Ye, Jianrong Miao, Jianling Liu, Yueen Chen, Xingbin Lan, Xiaoqing Liu, Wensong Yao, Jianchuan Sun, Jing Zheng, Jianzhong Xiao

Aim: This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. Methods: UCBMCs were injected once into the scrotal sheath cavity of elderly mice. Results: The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). Conclusion: Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.

目的:探讨同种异体脐带血单个核细胞(UCBMCs)阴囊移植对老年雄性小鼠性功能的影响。方法:老年小鼠阴囊鞘腔内一次性注射ucbmc。结果:移植的ucbmc在阴囊鞘腔内存活1个月。小鼠血睾酮浓度、环磷酸鸟苷(cGMP)水平和海肌体总一氧化氮合酶(T-NOS)活性显著升高,30分钟内小鼠交配次数增加(p = 0.000)。结论:阴囊植入ucbmc通过睾酮分泌和NOS/cGMP通路改善老年雄性小鼠性功能,可能为治疗勃起功能障碍提供一种创新的移植途径。
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引用次数: 0
Hope on the horizon: Wharton's jelly mesenchymal stem cells in the fight against COVID-19. 希望在地平线上:沃顿的果冻间充质干细胞在对抗COVID-19的斗争中。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0077
Gaurav Gupta, Md Sadique Hussain, Riya Thapa, Rajiv Dahiya, Debarshi Kar Mahapatra, Asif Ahmad Bhat, Neelam Singla, Vetriselvan Subramaniyan, Sushama Rawat, Vikas Jakhmola, Roshan S, Kamal Dua
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引用次数: 5
Perfusion in vivo bioreactor promotes regeneration of vascularized tissue-engineered bone. 体内生物反应器灌注促进血管化组织工程骨的再生。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0101
Peng Liu, Jian Wang, Yun Xue, Lei Zou, Yongzheng Tian, Ruilong Sun, Wenhua Zhang, Yunfei Li, Lijun Lv, Qiuming Gao, Bo Fan

Aim: This study improved the in vivo bioreactor (IVB) for bone regeneration by enhancing stem cell survival and promoting vascularized tissue-engineered bone. Methods: 12 New Zealand rabbits received β-TCP scaffolds with rabbit bone mesenchymal stem cells (BMSCs) implanted. Perfusion IVB with a perfusion electronic pump was compared with the control group using micro-CT, Microfil perfusion, histological staining and RT-PCR for gene expression. Results: Perfusion IVB demonstrated good biocompatibility, increased neoplastic bone tissue, neovascularization and upregulated osteogenic and angiogenesis-related genes in rabbits (p < 0.05). Conclusion: Perfusion IVB holds promise for bone regeneration and tissue engineering in orthopedics and maxillofacial surgery.

目的:通过提高干细胞存活率和促进血管化组织工程骨的形成,改进体内生物反应器(IVB)的骨再生功能。方法:12只新西兰兔植入兔骨间充质干细胞(BMSCs)的β-TCP支架。采用micro-CT、Microfil灌注、组织学染色及RT-PCR检测基因表达,将灌注电子泵灌注IVB与对照组进行比较。结果:灌注IVB在家兔中表现出良好的生物相容性,肿瘤骨组织、新生血管增加,成骨和血管生成相关基因上调(p)。结论:灌注IVB在骨科和颌面外科的骨再生和组织工程中具有前景。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in May 2023. 2023年5月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0111
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2023.

根据公开信息和非学术机构新闻稿汇编的干细胞研究和再生医学领域的最新进展。
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引用次数: 0
Comment on 'Digital transformation of medical education: innovative pedagogy and regenerative surgery in the era of COVID-19'. 评论“医学教育的数字化转型:新冠肺炎时代的创新教学法和再生外科”。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0081
Evelyn Casilla-Huamán
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引用次数: 0
Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review. 间充质干细胞治疗髋关节骨关节炎的最新证据:叙述性回顾。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0071
Mina Entessari, Leonardo P Oliveira

There are limited data on the use of mesenchymal stem cell injections for hip osteoarthritis. The goal of this study was to evaluate the literature by analyzing outcomes and comparing methodologies. Online search of PubMed, SportsDiscus and Case Reports Keywords was completed using the keywords 'stem cells' and 'hip' and 'osteoarthritis'. Six studies met the inclusion and exclusion criteria. Five out the six studies had statistically significant improvement in patient reported outcomes after mesenchymal stem cell injections. Only two studies provided information on radiological changes and findings were positive. None of the studies reported major complications. Small series of non-randomized controlled trials completed to date in the use of mesenchymal stem cells for the treatment of hip osteoarthritis reported the procedures to be safe and provide a positive clinical response. Randomized controlled trials must be performed to further confirm mesenchymal stem cells as a treatment option for hip osteoarthritis.

关于使用间充质干细胞注射治疗髋关节骨关节炎的数据有限。本研究的目的是通过分析结果和比较方法来评价文献。使用关键词“干细胞”、“髋关节”和“骨关节炎”完成PubMed、SportsDiscus和病例报告关键词的在线搜索。6项研究符合纳入和排除标准。六项研究中有五项在注射间充质干细胞后患者报告的结果有统计学显著改善。只有两项研究提供了有关放射学变化的信息,结果是阳性的。没有一项研究报告有重大并发症。迄今为止完成的使用间充质干细胞治疗髋关节骨关节炎的小系列非随机对照试验报告该程序是安全的,并提供了积极的临床反应。必须进行随机对照试验以进一步证实间充质干细胞作为髋关节骨关节炎的治疗选择。
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引用次数: 0
The role of osteoarthritis severity, BMI and age on clinical efficacy of bone marrow aspirate concentrate in the treatment of knee osteoarthritis. 骨性关节炎严重程度、BMI及年龄对骨髓浓缩液治疗膝关节骨性关节炎临床疗效的影响
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-09-01 DOI: 10.2217/rme-2023-0042
Predrag Rasovic, Oliver Dulic, Ivica Lalic, Radmila Matijevic, Natasa Janjic, Milan Tosic, Dejan Aleksandric, Dzihan Abazovic, Mladen Miskulin, Sara Matijevic, Luka Kovacevic

Aim: The aim of this study was to assess whether BMI, severity of knee osteoarthritis, age and gender have any influence on the final clinical results of bone marrow aspirate concentrate injection. Method: A total of 111 study participants with painful knee osteoarthritis and different characteristics concerning before mentioned factors underwent bone marrow aspirate concentrate (BMAC) therapy and were followed up for 1 year. Result: Significant pain and functional improvement were observed in all participant groups. Participants' age and BMI did not influence the clinical outcome, but there was an influence of OA severity, especially among older patients. Conclusion: This study shows that BMAC therapy is effective. Younger patients with milder OA changes could be better candidates for long-lasting and more efficient BMAC therapy. Clinical Trial Registration: NCT03825133 (ClinicalTrials.gov).

目的:本研究的目的是评估BMI、膝关节骨性关节炎的严重程度、年龄和性别是否对骨髓浓缩液注射的最终临床结果有影响。方法:对111例具有上述不同特征的疼痛性膝骨性关节炎患者进行浓缩骨髓抽吸治疗,随访1年。结果:两组患者疼痛及功能均有明显改善。参与者的年龄和BMI不影响临床结果,但OA严重程度有影响,特别是在老年患者中。结论:BMAC治疗是有效的。较轻OA改变的年轻患者可能更适合长期和更有效的BMAC治疗。临床试验注册:NCT03825133 (ClinicalTrials.gov)。
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Regenerative medicine
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