Tasneem Mohammed, A. Nasreen, Yahya S. Alqahtani, I. Shaikh, S. Iqubal, Shaik Honey Fathima, A. Khan
Green chemistry lowers chemical hazards during chemical design, manufacture, and use. By using cleaner solvents, catalysts, and reaction conditions, this technique reduces environmental pollution and boosts atom economy and energy efficiency. Rapid industrialization and urbanization are causing significant harm to our environment by releasing a lot of dangerous and undesired chemicals, gases, or other pollutants. The secrets hidden in nature and its by-products must now be discovered by us in order to enhance the synthesis of physiologically significant moieties and foster its growth. Heterocyclic compounds and its derivatives exhibit various biological potential like anticancer, antimicrobial, anticonvulsant, analgesic, antitubercular, antiinflammatory and cardiovascular activities. This make them good candidates for future medication discovery and give them the potential to be an arsenal for treating diseases. This article provides an overview of the numerous environmentally friendly and green synthetic techniques used to create diverse physiologically significant heterocyclic scaffolds in the period 2002–2022. It is anticipated that this compilation of pertinent information will be of significance and practical value to chemists specializing in organic and pharmaceutical domains, potentially stimulating additional advancements in reaction development within this captivating area of study.
{"title":"Green Synthesis of Therapeutically Active Heterocyclic Scaffolds: A Review","authors":"Tasneem Mohammed, A. Nasreen, Yahya S. Alqahtani, I. Shaikh, S. Iqubal, Shaik Honey Fathima, A. Khan","doi":"10.1166/sam.2023.4477","DOIUrl":"https://doi.org/10.1166/sam.2023.4477","url":null,"abstract":"Green chemistry lowers chemical hazards during chemical design, manufacture, and use. By using cleaner solvents, catalysts, and reaction conditions, this technique reduces environmental pollution and boosts atom economy and energy efficiency. Rapid industrialization and urbanization\u0000 are causing significant harm to our environment by releasing a lot of dangerous and undesired chemicals, gases, or other pollutants. The secrets hidden in nature and its by-products must now be discovered by us in order to enhance the synthesis of physiologically significant moieties and foster\u0000 its growth. Heterocyclic compounds and its derivatives exhibit various biological potential like anticancer, antimicrobial, anticonvulsant, analgesic, antitubercular, antiinflammatory and cardiovascular activities. This make them good candidates for future medication discovery and give them\u0000 the potential to be an arsenal for treating diseases. This article provides an overview of the numerous environmentally friendly and green synthetic techniques used to create diverse physiologically significant heterocyclic scaffolds in the period 2002–2022. It is anticipated that this\u0000 compilation of pertinent information will be of significance and practical value to chemists specializing in organic and pharmaceutical domains, potentially stimulating additional advancements in reaction development within this captivating area of study.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46655797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yan, W. Ding, Guojiang Liu, Hongyi Wang, Tengyu Ma
Taking two types of limestone with different mineral compositions as research objects, we conducted experiments on the mass, longitudinal wave velocity, ion concentration of solution, fracture morphology, and micromorphology of two types of limestone specimens eroded by acidic hydro-chemical solution. We investigated specimens’ damage time-dependent physical properties, dissolution, structure, discussing mineral composition effects and destruction. Results show that the mass loss rate of two types of limestone specimens eroded by acidic hydro-chemical solution increases with the increase of immersion time in a power function, and the longitudinal wave velocity decreases and then fluctuates in a small range. The specimen fracture degree increases with the increase of the immersion time, and the rock micro-structure changes from dense and uniform into loose and porous. The mass, the longitudinal wave velocity, the fracturing morphology, and damage to microscopic morphology of specimens increase with the increase of solution ion concentration. The acid rock reaction rate of limestone A is lower than that of limestone B, while the hydrolysis reaction rate is higher. The mass loss rate, the longitudinal wave velocity loss rate, the ion concentration, and the damage degree of the macro-and micro-structure of limestone A are higher than that of limestone B.
{"title":"Damage Time-Dependent Characteristics and Failure Mechanism of Limestone with Different Mineral Compositions Under Acid Hydro-Chemical Solution Erosion","authors":"Y. Yan, W. Ding, Guojiang Liu, Hongyi Wang, Tengyu Ma","doi":"10.1166/sam.2023.4419","DOIUrl":"https://doi.org/10.1166/sam.2023.4419","url":null,"abstract":"Taking two types of limestone with different mineral compositions as research objects, we conducted experiments on the mass, longitudinal wave velocity, ion concentration of solution, fracture morphology, and micromorphology of two types of limestone specimens eroded by acidic hydro-chemical\u0000 solution. We investigated specimens’ damage time-dependent physical properties, dissolution, structure, discussing mineral composition effects and destruction. Results show that the mass loss rate of two types of limestone specimens eroded by acidic hydro-chemical solution increases\u0000 with the increase of immersion time in a power function, and the longitudinal wave velocity decreases and then fluctuates in a small range. The specimen fracture degree increases with the increase of the immersion time, and the rock micro-structure changes from dense and uniform into loose\u0000 and porous. The mass, the longitudinal wave velocity, the fracturing morphology, and damage to microscopic morphology of specimens increase with the increase of solution ion concentration. The acid rock reaction rate of limestone A is lower than that of limestone B, while the hydrolysis reaction\u0000 rate is higher. The mass loss rate, the longitudinal wave velocity loss rate, the ion concentration, and the damage degree of the macro-and micro-structure of limestone A are higher than that of limestone B.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43365240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To determine the effect and mechanism of Insulin-like growth factor 1 (IGF-1) on papillary thyroid carcinoma (PTC) cells. We use TPC-1, one of PTC cell lines to evaluate the effects of IGF-1. SiRNA is used to reduce the effect of IGF-1R. In this study, TPC-1 cells were treated with recombinant human IGF-1, and the effects of IGF-1 on proliferation, migration, invasion and apoptosis of TPC-1 cells were studied by using Cell counting kit-8, 5-ethynyl-2′-deoxyuridine, colony formation, Transwell assay and flow cytometry. Compared with the control group, the proliferation ability of TPC-1 cells stimulated by IGF-1 was significantly increased. Cell cycle and apoptosis are not affected by IGF-1. IGF-1 enhances the ability of migration and invasion of TPC-1 cells. The expression of MMP2 increased and the expression of p53 decreased after IGF-1 stimulation in TPC-1 cells. After IGF-1 stimulation, the proliferation, migration and invasion ability of TPC-1 cells were enhanced. MMP2 and p53 may play an important role in proliferation and migration. This may provide a new therapeutic target for patients with PTC.
{"title":"Insulin-Like Growth Factor 1: A Promoter of Proliferation and Metastasis in Papillary Thyroid Carcinoma Cells","authors":"P. He, Yi Zhang","doi":"10.1166/sam.2023.4490","DOIUrl":"https://doi.org/10.1166/sam.2023.4490","url":null,"abstract":"To determine the effect and mechanism of Insulin-like growth factor 1 (IGF-1) on papillary thyroid carcinoma (PTC) cells. We use TPC-1, one of PTC cell lines to evaluate the effects of IGF-1. SiRNA is used to reduce the effect of IGF-1R. In this study, TPC-1 cells were treated with\u0000 recombinant human IGF-1, and the effects of IGF-1 on proliferation, migration, invasion and apoptosis of TPC-1 cells were studied by using Cell counting kit-8, 5-ethynyl-2′-deoxyuridine, colony formation, Transwell assay and flow cytometry. Compared with the control group, the proliferation\u0000 ability of TPC-1 cells stimulated by IGF-1 was significantly increased. Cell cycle and apoptosis are not affected by IGF-1. IGF-1 enhances the ability of migration and invasion of TPC-1 cells. The expression of MMP2 increased and the expression of p53 decreased after IGF-1 stimulation in TPC-1\u0000 cells. After IGF-1 stimulation, the proliferation, migration and invasion ability of TPC-1 cells were enhanced. MMP2 and p53 may play an important role in proliferation and migration. This may provide a new therapeutic target for patients with PTC.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46991389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper presents a “turn on” fluorescent assay with high sensitivity and rapidity for testing miRNA-195 on the basis of a novel FRET pair consisting of Lys-Au NCs (which have been successfully obtained through less than 2.5 min of synthesis via microwave (MW)-assisted technology) and carbon nanotubes (CNTs). Based on this FRET pair, given a detection limit set at 0.36 nM, miRNA-195 can be quantified in the range of 1–10000 nM. Moreover, the level of miRNA-195 in human serum was measured by virtue of this method, and a recovery of 98.6%–102.4% was achieved, demonstrating that the method put forward in this paper was applicable to actual samples for quantitatively examining miRNA-195.
{"title":"Carbon Nanotubes/Gold Nanoclusters Based “Turn on” FRET Fluorescent Assay for miRNA Detection","authors":"Lili Chen, Lingling Chen, Qiuhua Yang, Fengrong Zhang, Q. Qu","doi":"10.1166/sam.2023.4482","DOIUrl":"https://doi.org/10.1166/sam.2023.4482","url":null,"abstract":"This paper presents a “turn on” fluorescent assay with high sensitivity and rapidity for testing miRNA-195 on the basis of a novel FRET pair consisting of Lys-Au NCs (which have been successfully obtained through less than 2.5 min of synthesis via microwave (MW)-assisted\u0000 technology) and carbon nanotubes (CNTs). Based on this FRET pair, given a detection limit set at 0.36 nM, miRNA-195 can be quantified in the range of 1–10000 nM. Moreover, the level of miRNA-195 in human serum was measured by virtue of this method, and a recovery of 98.6%–102.4%\u0000 was achieved, demonstrating that the method put forward in this paper was applicable to actual samples for quantitatively examining miRNA-195.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49634033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Excessive release of phosphate has gained prominence as a pivotal contributor to water contamination. Biochar, known for its abundant surface acreage and unparalleled adsorptive prowess, has been widely employed in aqueous remediation. Within the scope of this investigation, unprocessed biochar was derived from Chaetomorpha valida via pyrolysis methodologies involving temperatures ranging from 320 °C, 460 °C, 620 °C, and 860 °C, respectively. Mg-BC620, Al-BC620, and Mg–Al-BC620 were prepared using the co-precipitation method at the optimal temperature to maximize the resource utilization of Chaetomorpha valida. The physicochemical attributes of altered biochars were evaluated employing X-ray diffractometry and other analytical techniques. The influence of different factors on phosphate’s adsorptive aptitude of altered biochar was investigated, and the adsorptive behavior and mechanism of biochar were studied using diverse kinetics of adsorption and assortment of isotherm models. The outcomes revealed that the optimal pyrolysis temperature was 620 °C, and the altered biochar displayed a strikingly elevated affinity for phosphate sorption, outperforming the unaltered biochar. Among the modified biochars, Mg–Al-BC620 outperformed the rest, boasting an astonishing eradication rate of 94.92% when dosed at 8 g/L, maintaining a pH equilibrium of 7 in the solution, while confronting an inceptive phosphate density of 150 mg/L. The utmost threshold of adsorption proficiency predicted by the Langmuir equation was 228.130 mg/g, which was 88.56 times that of BC620. This modified biochar exhibits a strong affinity for phosphate and excellent adsorption selectivity, providing a promising avenue for the resource utilization of Chaetomorpha valida and has broad application prospects for scavenging phosphate in aqueous mediums.
{"title":"Study on Adsorption of Phosphate in Water Environment by Mg–Al Modified Biochar","authors":"Dan Yang, Shou-Kun Chen, Chengtao Xu, Zhou Zhou","doi":"10.1166/sam.2023.4479","DOIUrl":"https://doi.org/10.1166/sam.2023.4479","url":null,"abstract":"Excessive release of phosphate has gained prominence as a pivotal contributor to water contamination. Biochar, known for its abundant surface acreage and unparalleled adsorptive prowess, has been widely employed in aqueous remediation. Within the scope of this investigation, unprocessed\u0000 biochar was derived from Chaetomorpha valida via pyrolysis methodologies involving temperatures ranging from 320 °C, 460 °C, 620 °C, and 860 °C, respectively. Mg-BC620, Al-BC620, and Mg–Al-BC620 were prepared using the co-precipitation\u0000 method at the optimal temperature to maximize the resource utilization of Chaetomorpha valida. The physicochemical attributes of altered biochars were evaluated employing X-ray diffractometry and other analytical techniques. The influence of different factors on phosphate’s adsorptive\u0000 aptitude of altered biochar was investigated, and the adsorptive behavior and mechanism of biochar were studied using diverse kinetics of adsorption and assortment of isotherm models. The outcomes revealed that the optimal pyrolysis temperature was 620 °C, and the altered biochar displayed\u0000 a strikingly elevated affinity for phosphate sorption, outperforming the unaltered biochar. Among the modified biochars, Mg–Al-BC620 outperformed the rest, boasting an astonishing eradication rate of 94.92% when dosed at 8 g/L, maintaining a pH equilibrium of 7 in the solution,\u0000 while confronting an inceptive phosphate density of 150 mg/L. The utmost threshold of adsorption proficiency predicted by the Langmuir equation was 228.130 mg/g, which was 88.56 times that of BC620. This modified biochar exhibits a strong affinity for phosphate and excellent adsorption\u0000 selectivity, providing a promising avenue for the resource utilization of Chaetomorpha valida and has broad application prospects for scavenging phosphate in aqueous mediums.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49084988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. B. R. Kamalam, J. Menaka, S. S. R. Inbanathan, K. Sethuraman, A. Shahid, H. Fouad, S. Hussain
Appropriate wastewater treatment methods for effectual and practical decontamination of wastewater bodies is the prime goal of today’s environmentalists and industrialists. Herein, sunlight driven photocatalytic degradation of rhodamine-B (RhB) has been investigated by employing hydrothermally synthesized tin oxide-graphene oxide (SnO2/GO) nanocomposite. Physiochemical characterization of composite has been accomplished via X-ray diffraction (XRD) analysis, ultraviolet (UV) spectroscopy, diffused reflectance spectroscopy (DRS) and photoluminescence (PL). Photocatalytic degradation of RhB is studied using UV light and spectrophotometer. SnO2-GO nanocomposite degraded the RhB dye in 120 min comparatively in quite lesser time than separate SnO2 and GO degradation performances. The incorporation of GO into SnO2 decreases the rate of electron–hole recombination, increases the oxidation of carriers as well as the rate of carrier separation owing to the synergistic impact of GO and SnO2. Therefore, an affordable graphene oxide supported SnO2 nanocomposite can be implicated as efficacious real wastewater treatment method at industrial scale.
适当的废水处理方法对废水体进行有效和实际的净化是当今环保主义者和工业家的首要目标。本文采用水热合成的氧化锡-氧化石墨烯(SnO2/GO)纳米复合材料，研究了阳光驱动的光催化降解罗丹明- b (RhB)。通过x射线衍射(XRD)分析、紫外(UV)光谱、漫反射光谱(DRS)和光致发光(PL)对复合材料进行了理化表征。采用紫外光和分光光度计研究了RhB的光催化降解。SnO2-GO纳米复合材料降解RhB染料的时间为120 min，比单独降解SnO2和GO的时间短得多。由于氧化石墨烯与SnO2的协同作用，氧化石墨烯掺入SnO2降低了电子-空穴复合的速率，增加了载流子的氧化和载流子的分离速率。因此，一种经济实惠的氧化石墨烯负载的SnO2纳米复合材料可以作为工业规模上有效的真正的废水处理方法。
{"title":"Tin Oxide-Graphene Oxide (SnO2/GO) Nanocomposite: A Promising Photocatalyst for Rhodamine-B Dye Degradation","authors":"M. B. R. Kamalam, J. Menaka, S. S. R. Inbanathan, K. Sethuraman, A. Shahid, H. Fouad, S. Hussain","doi":"10.1166/sam.2023.4465","DOIUrl":"https://doi.org/10.1166/sam.2023.4465","url":null,"abstract":"Appropriate wastewater treatment methods for effectual and practical decontamination of wastewater bodies is the prime goal of today’s environmentalists and industrialists. Herein, sunlight driven photocatalytic degradation of rhodamine-B (RhB) has been investigated by employing\u0000 hydrothermally synthesized tin oxide-graphene oxide (SnO2/GO) nanocomposite. Physiochemical characterization of composite has been accomplished via X-ray diffraction (XRD) analysis, ultraviolet (UV) spectroscopy, diffused reflectance spectroscopy (DRS) and photoluminescence (PL).\u0000 Photocatalytic degradation of RhB is studied using UV light and spectrophotometer. SnO2-GO nanocomposite degraded the RhB dye in 120 min comparatively in quite lesser time than separate SnO2 and GO degradation performances. The incorporation of GO into SnO2\u0000 decreases the rate of electron–hole recombination, increases the oxidation of carriers as well as the rate of carrier separation owing to the synergistic impact of GO and SnO2. Therefore, an affordable graphene oxide supported SnO2 nanocomposite can be implicated\u0000 as efficacious real wastewater treatment method at industrial scale.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43522064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ahmad, J. Ahmad, Basel A. Abdel-Wahab, Ali S. Alasiri, H. F. Alotaibi, Abdulhakeem Mohammed Saeed, F. A. Mahboob, Osman A. E. Elnoubi, S. Wahab, Zufesha NoorulHuda Khan
Green synthesis or biosynthesis of nanoparticles (NPs) has recently emerged as a significant approach to producing metallic NPs due to its rapid, affordable and ease of fabrication. Silver nanoparticles (AgNPs) are particularly impressive due to their antimicrobial, bacteriostatic, and low in vivo toxicity. Wound healing is a complex procedure involving the activity of various tissues and cell lineages that have long been the topic of intense research. A faster and more efficient recovery with the minimum side effects is one of the key goals in wound healing. The current study aims to perform a green synthesis of AgNPs mediated by Solenostemma argel leaf extract, combine it with chitosan (CS) gel, and evaluate its effectiveness as a wound healing agent in a rat model. The biosynthesized AgNPs were characterized by UV-visible spectroscopy, FTIR, XRD, DLS analysis and SEM imaging. The developed AgNPs were spherical, with sizes ranging from 60–90 nm. Analysis of the UV-visible spectrum revealed a strong peak at 418.02 nm; this was the first indication of the biosynthesis of AgNPs. X-Ray diffraction analysis indicated the crystallinity phase of biosynthesized AgNPs. The mean hydrodynamic diameter and PDI of the biosynthesized AgNPs were 71.38±2.73 nm and 0.208±0.01, respectively. A high negative zeta potential (30.95±0.58 mV) indicates that the nanomaterial is highly stabilized. The developed AgNPs were uniformly dispersed with 2% w/v CS solution to form AgNPs/CS gel. The in-vivo animal experiment and histopathological analysis outcomes revealed that groups of wounded animals receiving the topical application of AgNPs/CS-gel experienced quicker and better wound healing. Based on this outcome, it can be concluded that biosynthesized AgNPs developed into AgNPs/CS-gel have great potential to be established as wound healing agents.
{"title":"Green Synthesis of Silver Nanoparticles from Solenostemma argel Leaf Extract: Characterization and Wound Healing Activity","authors":"M. Ahmad, J. Ahmad, Basel A. Abdel-Wahab, Ali S. Alasiri, H. F. Alotaibi, Abdulhakeem Mohammed Saeed, F. A. Mahboob, Osman A. E. Elnoubi, S. Wahab, Zufesha NoorulHuda Khan","doi":"10.1166/sam.2023.4472","DOIUrl":"https://doi.org/10.1166/sam.2023.4472","url":null,"abstract":"Green synthesis or biosynthesis of nanoparticles (NPs) has recently emerged as a significant approach to producing metallic NPs due to its rapid, affordable and ease of fabrication. Silver nanoparticles (AgNPs) are particularly impressive due to their antimicrobial, bacteriostatic,\u0000 and low in vivo toxicity. Wound healing is a complex procedure involving the activity of various tissues and cell lineages that have long been the topic of intense research. A faster and more efficient recovery with the minimum side effects is one of the key goals in wound healing.\u0000 The current study aims to perform a green synthesis of AgNPs mediated by Solenostemma argel leaf extract, combine it with chitosan (CS) gel, and evaluate its effectiveness as a wound healing agent in a rat model. The biosynthesized AgNPs were characterized by UV-visible spectroscopy,\u0000 FTIR, XRD, DLS analysis and SEM imaging. The developed AgNPs were spherical, with sizes ranging from 60–90 nm. Analysis of the UV-visible spectrum revealed a strong peak at 418.02 nm; this was the first indication of the biosynthesis of AgNPs. X-Ray diffraction analysis indicated the\u0000 crystallinity phase of biosynthesized AgNPs. The mean hydrodynamic diameter and PDI of the biosynthesized AgNPs were 71.38±2.73 nm and 0.208±0.01, respectively. A high negative zeta potential (30.95±0.58 mV) indicates that the nanomaterial is highly stabilized. The developed\u0000 AgNPs were uniformly dispersed with 2% w/v CS solution to form AgNPs/CS gel. The in-vivo animal experiment and histopathological analysis outcomes revealed that groups of wounded animals receiving the topical application of AgNPs/CS-gel experienced quicker and better wound healing.\u0000 Based on this outcome, it can be concluded that biosynthesized AgNPs developed into AgNPs/CS-gel have great potential to be established as wound healing agents.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48951717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anas O. K. Abu Bokha, Mingyang Song, Chen-He Li, Ahmad M. Zalloom, Rui Li
This study investigated the regulatory role of long non-coding RNA (lncRNA) MALAT1 in HA-VSMCs proliferation and apoptosis through mediating PTEN level. HA-VSMCs were induced with different doses of ox-LDL for various time points, and the relative level of MALAT1 was determined. MALAT1 was upregulated in a time- and dose-dependent manner. Overexpression of MALAT1 increased viability and proliferative rate, and decreased apoptotic rate of HA-VSMCs induced with 100 mg/L ox-LDL for 24 h, which was reversed by si-MALAT1 transfection. PTEN protein level was downregulated by ox-LDL induction and upregulated by si-MALAT1. MALAT1 was mainly distributed in the nucleus, and it interacted with EZH2. Silencing of MALAT1 attenuated EZH2 binding on PTEN promoter region. Knockdown of PTEN reversed the decreased proliferative ability and increased apoptotic rate in ox-LDL-induced HA-VSMCs transfected with si-MALAT1. These results indicate that MALAT1 accelerates HA-VSMCs proliferation by recruiting EZH2 to mediate PTEN level. Overall, MALAT1 may play a crucial role in the progression of atherosclerosis and may be a potential therapeutic target.
{"title":"Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1: Epigenetic Regulation of PTEN in Mediating Vascular Smooth Muscle Cell Proliferation and Apoptosis","authors":"Anas O. K. Abu Bokha, Mingyang Song, Chen-He Li, Ahmad M. Zalloom, Rui Li","doi":"10.1166/sam.2023.4485","DOIUrl":"https://doi.org/10.1166/sam.2023.4485","url":null,"abstract":"This study investigated the regulatory role of long non-coding RNA (lncRNA) MALAT1 in HA-VSMCs proliferation and apoptosis through mediating PTEN level. HA-VSMCs were induced with different doses of ox-LDL for various time points, and the relative level of MALAT1 was determined. MALAT1\u0000 was upregulated in a time- and dose-dependent manner. Overexpression of MALAT1 increased viability and proliferative rate, and decreased apoptotic rate of HA-VSMCs induced with 100 mg/L ox-LDL for 24 h, which was reversed by si-MALAT1 transfection. PTEN protein level was downregulated by ox-LDL\u0000 induction and upregulated by si-MALAT1. MALAT1 was mainly distributed in the nucleus, and it interacted with EZH2. Silencing of MALAT1 attenuated EZH2 binding on PTEN promoter region. Knockdown of PTEN reversed the decreased proliferative ability and increased apoptotic rate in ox-LDL-induced\u0000 HA-VSMCs transfected with si-MALAT1. These results indicate that MALAT1 accelerates HA-VSMCs proliferation by recruiting EZH2 to mediate PTEN level. Overall, MALAT1 may play a crucial role in the progression of atherosclerosis and may be a potential therapeutic target.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47957639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Continuous improvements in sports equipment are crucial for enhancing performance and ensuring safety. Carbon fiber composites, comprising carbon fibers and a matrix such as resin, metal, or ceramics, have exceptional strength and stiffness properties. This study focused on the application of carbon fiber reinforced composites in sports equipment, with an emphasis on optimizing the stiffness of lightweight equipment. The research revealed that fiber-wound composites exhibit nonlinear behavior, and the overlapping fiber structure can impede damage propagation, leading to greater in-plane shear failure strain compared to composite laminates. The study aimed to predict the mechanical behavior and structural stiffness of fiber-wound composite sports equipment reinforced with carbon fibers. The findings can be used to improve the design and manufacturing process of sports equipment, leading to better performance and durability. The utilization of these materials in sports equipment may also contribute to reducing the weight of the equipment, thereby enhancing athlete’s performance and reducing the risk of injury.
{"title":"Structural Stiffness and Mechanical Analysis of Fiber Wound Composite Sports Equipment Reinforced with Carbon Fiber Materials","authors":"Jian Guo","doi":"10.1166/sam.2023.4469","DOIUrl":"https://doi.org/10.1166/sam.2023.4469","url":null,"abstract":"Continuous improvements in sports equipment are crucial for enhancing performance and ensuring safety. Carbon fiber composites, comprising carbon fibers and a matrix such as resin, metal, or ceramics, have exceptional strength and stiffness properties. This study focused on the application\u0000 of carbon fiber reinforced composites in sports equipment, with an emphasis on optimizing the stiffness of lightweight equipment. The research revealed that fiber-wound composites exhibit nonlinear behavior, and the overlapping fiber structure can impede damage propagation, leading to greater\u0000 in-plane shear failure strain compared to composite laminates. The study aimed to predict the mechanical behavior and structural stiffness of fiber-wound composite sports equipment reinforced with carbon fibers. The findings can be used to improve the design and manufacturing process of sports\u0000 equipment, leading to better performance and durability. The utilization of these materials in sports equipment may also contribute to reducing the weight of the equipment, thereby enhancing athlete’s performance and reducing the risk of injury.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41541048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Tian, Qiumei Lei, Wenyao Li, Anna Su, M. Hashem, Tao Ji
TiO2-based devices are known for their responsive behavior to environmental conditions. In this study, we report the fabrication of a locally N-doped TiO2/p-Si (100) heterojunction UV-vis photodetector, achieved through a series of processes including magnetron sputtering, high-temperature annealing, hydrothermal synthesis, and thermal evaporation. Due to surface oxygen adsorption and partial nitrogen doping in TiO2, the photocurrent of the device was found to be higher in vacuum than in air at low voltage, and lower in vacuum than in air at higher voltage. Moreover, the photocurrent was more likely to reach saturation under vacuum at low voltage. Under UV light illumination (380 nm), the voltage applied to the device to reach the saturation currents in vacuum and air were approximately −1 V and −1.5 V, respectively, and these values increased slightly when illuminated by visible light (480 nm). The study of the impact of oxygen adsorption and partial N doping in TiO2 on the hindrance and multiplier effects of carrier movement in photodetectors can be beneficial for the development and application of wearable, biosensing, and vacuum sensing devices.
{"title":"Influence of Oxygen Adsorption on Local N-Doped TiO2/p-Si (100) Heterojunction UV-Visible Photodetector","authors":"G. Tian, Qiumei Lei, Wenyao Li, Anna Su, M. Hashem, Tao Ji","doi":"10.1166/sam.2023.4467","DOIUrl":"https://doi.org/10.1166/sam.2023.4467","url":null,"abstract":"TiO2-based devices are known for their responsive behavior to environmental conditions. In this study, we report the fabrication of a locally N-doped TiO2/p-Si (100) heterojunction UV-vis photodetector, achieved through a series of processes including magnetron\u0000 sputtering, high-temperature annealing, hydrothermal synthesis, and thermal evaporation. Due to surface oxygen adsorption and partial nitrogen doping in TiO2, the photocurrent of the device was found to be higher in vacuum than in air at low voltage, and lower in vacuum than in\u0000 air at higher voltage. Moreover, the photocurrent was more likely to reach saturation under vacuum at low voltage. Under UV light illumination (380 nm), the voltage applied to the device to reach the saturation currents in vacuum and air were approximately −1 V and −1.5 V, respectively,\u0000 and these values increased slightly when illuminated by visible light (480 nm). The study of the impact of oxygen adsorption and partial N doping in TiO2 on the hindrance and multiplier effects of carrier movement in photodetectors can be beneficial for the development and application\u0000 of wearable, biosensing, and vacuum sensing devices.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46066478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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