Pub Date : 2025-11-26DOI: 10.1007/s40279-025-02352-w
Renjie Bing, Jianyu Gan, Dapeng Bao
{"title":"Comment on “Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults”","authors":"Renjie Bing, Jianyu Gan, Dapeng Bao","doi":"10.1007/s40279-025-02352-w","DOIUrl":"https://doi.org/10.1007/s40279-025-02352-w","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"29 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1007/s40279-025-02351-x
Milan W. Betz, Alejandra P. Monsegue, Lex B. Verdijk, Luc J. C. van Loon, Tim Snijders
{"title":"Response to Comment on “Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults”","authors":"Milan W. Betz, Alejandra P. Monsegue, Lex B. Verdijk, Luc J. C. van Loon, Tim Snijders","doi":"10.1007/s40279-025-02351-x","DOIUrl":"https://doi.org/10.1007/s40279-025-02351-x","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"1 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1007/s40279-025-02358-4
Hugo Silva, Juan Del Coso, Craig Pickering
{"title":"Response to Comment on “Caffeine and Sports Performance: The Conflict between Caffeine Intake to Enhance Performance and Avoiding Caffeine to Ensure Sleep Quality”","authors":"Hugo Silva, Juan Del Coso, Craig Pickering","doi":"10.1007/s40279-025-02358-4","DOIUrl":"https://doi.org/10.1007/s40279-025-02358-4","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"20 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1007/s40279-025-02362-8
Nikola Todorovic
{"title":"Comment on “Caffeine and Sports Performance: The Conflict Between Caffeine Intake to Enhance Performance and Avoiding Caffeine to Ensure Sleep Quality”","authors":"Nikola Todorovic","doi":"10.1007/s40279-025-02362-8","DOIUrl":"https://doi.org/10.1007/s40279-025-02362-8","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"10 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1007/s40279-025-02368-2
David Varillas-Delgado, Estela Villaoslada, Laura Clavaín
{"title":"ACTN3 c.1729C>T Polymorphism Might Not Be a Standalone Factor in Non-contact Musculoskeletal Injury: A Systematic Review and Meta-analysis","authors":"David Varillas-Delgado, Estela Villaoslada, Laura Clavaín","doi":"10.1007/s40279-025-02368-2","DOIUrl":"https://doi.org/10.1007/s40279-025-02368-2","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"19 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1007/s40279-025-02346-8
Ibnu Noufal Kambitta Valappil, Karuppasamy Govindasamy, Gavoutamane Vasanthi, Masilamani Elayaraja, Cain C. T. Clark, Koulla Parpa, Borko Katanic, Hüseyin Şahin Uysal, Hassane Zouhal, Urs Granacher
Background Soccer is a high-intensity sport that requires high levels of physical fitness, including balance, change of direction (CoD), speed and power. The FIFA 11 + program has been widely promoted to enhance physical fitness and reduce injury occurrence. Objective This meta-analysis set out to examine how the FIFA 11 + program, implemented as a warm-up versus conventional warm-up (soccer-specific and alternative warm-ups), impacts physical fitness attributes in youth and adult soccer players. Methods After a priori defined inclusion and exclusion criteria, 17 intervention studies with 611 male and female soccer players (Tier 2–4) aged 9–29 years were eligible to be included. The FIFA 11 + program implemented in the warm-up was contrasted with conventional warm-up programs (control) on outcome measures such as dynamic balance, CoD speed, linear sprint and proxies of muscle power (vertical jump height). The influence of potential moderators (e.g., training duration, frequency, session duration, age, sex, training and performance calibre) on study outcome measures was examined using subgroup analyses with the median split method. Results Findings demonstrated small-to-moderate improvements in favour of FIFA 11 + compared with conventional warm-ups on dynamic balance (small standardized mean differences [SMDs] = 0.37, <jats:italic>p</jats:italic> < 0.001, heterogeneity [ <jats:italic>I</jats:italic> <jats:sup>2</jats:sup> ] = 7), CoD speed (moderate SMDs = − 0.65, <jats:italic>p</jats:italic> = 0.005, <jats:italic>I</jats:italic> <jats:sup>2</jats:sup> = 84), and vertical jump height (small SMDs = 0.56, <jats:italic>p</jats:italic> < 0.001, <jats:italic>I</jats:italic> <jats:sup>2</jats:sup> = 71). Results from the sub-analyses showed that, for dynamic balance, shorter training durations (< 9 weeks) produced larger effects than longer durations (≥ 9 weeks) (SMDs = 0.62 versus SMDs = 0.17). For vertical jump height, < 9 weeks also yielded greater improvements (SMDs = 0.79 versus SMDs = 0.26). In terms of weekly training frequency, ≥ 3 sessions/week elicited larger gains in change-of-direction speed (SMDs = − 1.05 versus SMDs = − 0.12) and vertical jump height (SMDs = 0.73 versus SMDs = 0.01) compared with < 3 sessions/week. Regarding participant characteristics, players aged ≥ 18 years showed greater improvements than those < 18 years in change-of-direction speed (SMDs = − 1.45 versus SMDs = − 0.06) and vertical jump height (SMDs = 0.64 versus SMDs = 0.22). For sex differences, males experienced greater benefits than females in change-of-direction speed (SMDs = − 0.79 versus SMDs = − 0.04) and vertical jump height (SMDs = 0.54 versus SMDs = 0.09). Finally, higher-level players (≥ tier 3) demonstrated greater improvements in vertical jump height than lower-tier players (< Tier 3) (SMDs = 0.75 versus SMDs = 0.01). The observed benefits were statistically significant but generally of small-to-moderate magnitude and affected by st
足球是一项高强度的运动,对身体素质要求很高,包括平衡、方向变化(CoD)、速度和力量。国际足联11 +计划已被广泛推广,以提高身体素质,减少伤害的发生。本荟萃分析旨在研究FIFA 11 +项目作为热身活动与常规热身活动(足球专项热身和替代热身活动)的对比,对青少年和成年足球运动员的身体健康属性有何影响。方法根据先验定义的纳入和排除标准,纳入17项干预研究,涉及611名9-29岁的男女足球运动员(2-4级)。在动态平衡、CoD速度、线性冲刺和肌肉力量指标(垂直起跳高度)等结果指标上,将在热身中实施的FIFA 11 +计划与常规热身计划(对照组)进行对比。潜在调节因素(如训练时间、频率、训练持续时间、年龄、性别、训练和表现水平)对研究结果测量的影响采用中位数分裂法进行亚组分析。结果发现,与传统热身相比,FIFA 11 +在动态平衡(标准化平均差异小[SMDs] = 0.37, p < 0.001,异质性[i2] = 7)、CoD速度(中等SMDs = - 0.65, p = 0.005, i2 = 84)和垂直跳跃高度(小SMDs = 0.56, p < 0.001, i2 = 71)方面有小到中度的改善。子分析结果显示,对于动态平衡,较短的训练时间(≤9周)比较长的训练时间(≥9周)产生更大的效果(SMDs = 0.62 vs . SMDs = 0.17)。对于垂直跳跃高度,9周也有更大的改善(SMDs = 0.79 vs . SMDs = 0.26)。就每周训练频率而言,与每周训练3次相比,≥3次/周在方向变化速度(SMDs = - 1.05 vs . SMDs = - 0.12)和垂直跳跃高度(SMDs = 0.73 vs . SMDs = 0.01)方面的收益更大。在参与者特征方面,年龄≥18岁的运动员在方向变化速度(SMDs = - 1.45 vs . SMDs = - 0.06)和垂直跳跃高度(SMDs = 0.64 vs . SMDs = 0.22)方面比年龄≥18岁的运动员有更大的改善。在性别差异方面,男性在方向变化速度(SMDs = - 0.79 vs . - 0.04)和垂直跳跃高度(SMDs = 0.54 vs . 0.09)方面的优势大于女性。最后,高水平的玩家(≥3级)比低水平的玩家(<; 3级)在垂直跳跃高度上表现出更大的进步(SMDs = 0.75 vs . SMDs = 0.01)。观察到的益处在统计学上是显著的,但通常是小到中等程度的,并受到研究异质性和项目实施差异的影响。大多数研究包括男性参与者,限制了对女性和代表性不足人群的推广。一些研究也缺乏严格的方法设计,特别是在分配、隐藏和盲法方面。关于培训和人口变数的报告往往不完整。这些局限性强调了严格设计、低偏倚随机对照试验的必要性,并标准化实施FIFA 11 +项目和全面报告,以提高因果结论的可靠性并改善临床解释。结论FIFA 11 +项目比传统的足球热身项目更能提高运动员的身体素质(动平衡、CoD速度、垂直起跳高度)。训练时间越短(9周),每周训练次数越多(≥3次/周),训练效果越明显。《FIFA 11 +》对年龄较大(≥18岁)、男性球员和水平较高(≥3级)的球员更有效。这些发现强调了FIFA 11 +项目在提高足球运动员身体素质方面的多功能性,支持将其纳入常规足球训练的热身课程。协议注册https://www.crd.york.ac.uk/PROSPERO/view/CRD42025633810, PROSPERO: CRD42025633810。图形化的
{"title":"Effects of the FIFA 11 + Program on Physical Fitness in Youth and Adult Soccer Players: A Systematic Review and Meta-analysis","authors":"Ibnu Noufal Kambitta Valappil, Karuppasamy Govindasamy, Gavoutamane Vasanthi, Masilamani Elayaraja, Cain C. T. Clark, Koulla Parpa, Borko Katanic, Hüseyin Şahin Uysal, Hassane Zouhal, Urs Granacher","doi":"10.1007/s40279-025-02346-8","DOIUrl":"https://doi.org/10.1007/s40279-025-02346-8","url":null,"abstract":"Background Soccer is a high-intensity sport that requires high levels of physical fitness, including balance, change of direction (CoD), speed and power. The FIFA 11 + program has been widely promoted to enhance physical fitness and reduce injury occurrence. Objective This meta-analysis set out to examine how the FIFA 11 + program, implemented as a warm-up versus conventional warm-up (soccer-specific and alternative warm-ups), impacts physical fitness attributes in youth and adult soccer players. Methods After a priori defined inclusion and exclusion criteria, 17 intervention studies with 611 male and female soccer players (Tier 2–4) aged 9–29 years were eligible to be included. The FIFA 11 + program implemented in the warm-up was contrasted with conventional warm-up programs (control) on outcome measures such as dynamic balance, CoD speed, linear sprint and proxies of muscle power (vertical jump height). The influence of potential moderators (e.g., training duration, frequency, session duration, age, sex, training and performance calibre) on study outcome measures was examined using subgroup analyses with the median split method. Results Findings demonstrated small-to-moderate improvements in favour of FIFA 11 + compared with conventional warm-ups on dynamic balance (small standardized mean differences [SMDs] = 0.37, <jats:italic>p</jats:italic> < 0.001, heterogeneity [ <jats:italic>I</jats:italic> <jats:sup>2</jats:sup> ] = 7), CoD speed (moderate SMDs = − 0.65, <jats:italic>p</jats:italic> = 0.005, <jats:italic>I</jats:italic> <jats:sup>2</jats:sup> = 84), and vertical jump height (small SMDs = 0.56, <jats:italic>p</jats:italic> < 0.001, <jats:italic>I</jats:italic> <jats:sup>2</jats:sup> = 71). Results from the sub-analyses showed that, for dynamic balance, shorter training durations (< 9 weeks) produced larger effects than longer durations (≥ 9 weeks) (SMDs = 0.62 versus SMDs = 0.17). For vertical jump height, < 9 weeks also yielded greater improvements (SMDs = 0.79 versus SMDs = 0.26). In terms of weekly training frequency, ≥ 3 sessions/week elicited larger gains in change-of-direction speed (SMDs = − 1.05 versus SMDs = − 0.12) and vertical jump height (SMDs = 0.73 versus SMDs = 0.01) compared with < 3 sessions/week. Regarding participant characteristics, players aged ≥ 18 years showed greater improvements than those < 18 years in change-of-direction speed (SMDs = − 1.45 versus SMDs = − 0.06) and vertical jump height (SMDs = 0.64 versus SMDs = 0.22). For sex differences, males experienced greater benefits than females in change-of-direction speed (SMDs = − 0.79 versus SMDs = − 0.04) and vertical jump height (SMDs = 0.54 versus SMDs = 0.09). Finally, higher-level players (≥ tier 3) demonstrated greater improvements in vertical jump height than lower-tier players (< Tier 3) (SMDs = 0.75 versus SMDs = 0.01). The observed benefits were statistically significant but generally of small-to-moderate magnitude and affected by st","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"205 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1007/s40279-025-02366-4
Carles Pedret, Sandra Mechó, Gulraiz Ahmad, Gil Rodas, Ramon Balius
{"title":"A New Anatomical Approach to T-Junction Hamstring Injuries","authors":"Carles Pedret, Sandra Mechó, Gulraiz Ahmad, Gil Rodas, Ramon Balius","doi":"10.1007/s40279-025-02366-4","DOIUrl":"https://doi.org/10.1007/s40279-025-02366-4","url":null,"abstract":"","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"109 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-24DOI: 10.1007/s40279-025-02338-8
Ritva S. Mikkonen, Johanna K. Ihalainen, Georgie Bruinvels, Nonhlanhla S. Mkumbuzi, Abbie E. Smith-Ryan, Mira Kaikkonen, Malita Kasongo, Anthony C. Hackney
Monitoring menstrual health has gained popularity in sports like football as an opportunity to identify recurring symptoms or adverse symptoms related to the menstrual or hormonal contraceptive cycle; to recognize challenges related to low energy availability (LEA), low carbohydrate availability, overreaching/overtraining, and/or overall lifestyle stress due to their association with menstrual disturbance/dysfunction; to be informative in contextualizing athlete training status, e.g., training load and performance progression; and to promote and empower body/health literacy and overall health in female athletes. Monitoring menstrual health may also offer valuable insights to inform decisions regarding training and recovery. In team sports like football, where training loads and match schedules are relatively uniform across the squad, individualized strategies to effectively manage recurring adverse symptoms or menstrual disturbance/dysfunction may be necessary to ensure that all athletes can perform and recover optimally. The purpose of this article is to describe the rationale and suggested approaches for tracking menstrual and hormonal contraceptive cycles (including menstrual disturbance/dysfunction) in field settings to facilitate monitoring of menstrual health to potentially contextualize the other health and performance data. Herein, we assess the feasibility and potential limitations of different tracking methods from traditional paper and pencil records to more sophisticated digital applications and biochemical measures for use in real-world settings.
{"title":"Monitoring Menstrual Health in Footballers: Considerations for Tracking Menstrual and Hormonal Contraceptive Cycles in the Field to Support Performance","authors":"Ritva S. Mikkonen, Johanna K. Ihalainen, Georgie Bruinvels, Nonhlanhla S. Mkumbuzi, Abbie E. Smith-Ryan, Mira Kaikkonen, Malita Kasongo, Anthony C. Hackney","doi":"10.1007/s40279-025-02338-8","DOIUrl":"https://doi.org/10.1007/s40279-025-02338-8","url":null,"abstract":"Monitoring menstrual health has gained popularity in sports like football as an opportunity to identify recurring symptoms or adverse symptoms related to the menstrual or hormonal contraceptive cycle; to recognize challenges related to low energy availability (LEA), low carbohydrate availability, overreaching/overtraining, and/or overall lifestyle stress due to their association with menstrual disturbance/dysfunction; to be informative in contextualizing athlete training status, e.g., training load and performance progression; and to promote and empower body/health literacy and overall health in female athletes. Monitoring menstrual health may also offer valuable insights to inform decisions regarding training and recovery. In team sports like football, where training loads and match schedules are relatively uniform across the squad, individualized strategies to effectively manage recurring adverse symptoms or menstrual disturbance/dysfunction may be necessary to ensure that all athletes can perform and recover optimally. The purpose of this article is to describe the rationale and suggested approaches for tracking menstrual and hormonal contraceptive cycles (including menstrual disturbance/dysfunction) in field settings to facilitate monitoring of menstrual health to potentially contextualize the other health and performance data. Herein, we assess the feasibility and potential limitations of different tracking methods from traditional paper and pencil records to more sophisticated digital applications and biochemical measures for use in real-world settings.","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"84 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1007/s40279-025-02357-5
Paula Etayo-Urtasun, Mikel Izquierdo, Mikel L. Sáez de Asteasu
Background Physical exercise has been proposed to enhance cardiovascular autonomic function; however, current evidence in older populations remains controversial. Objective This systematic review and meta-analysis aimed to examine the effects of physical exercise on autonomic cardiovascular function in older adults. Methods A systematic literature search was conducted in PubMed, Web of Science, Scopus, and ScienceDirect on March 12, 2025, following PRISMA 2020 guidelines. Two independent reviewers applied the PICOS model to screen randomised controlled trials (RCTs) published since 2010 that investigated the effects of exercise interventions on autonomic cardiovascular function in older adults. Methodological quality was assessed using the PEDro scale. Standardised mean differences (SMD) and 95% confidence intervals (CI) were calculated through random effects models using the Empirical Bayes method. This systematic review and meta-analysis was registered in PROSPERO (CRD420250651364). Results Fifteen RCTs were included in the meta-analysis. Exercise interventions significantly increased the root mean square of the successive differences (RMSSD) (SMD 0.636, 95% confidence interval [CI] 0.014–1.258; p = 0.045) and significantly decreased the low-frequency / high-frequency (LF/HF) ratio (SMD − 0.506, 95% CI − 0.954 to − 0.057; p = 0.027). No significant effects were found for the standard deviation of normal-to-normal intervals (SDNN) (SMD 0.718, 95% CI − 0.120 to 1.557; p = 0.093) or baroreflex sensitivity (SMD − 0.137, 95% CI − 0.670 to 0.396; p = 0.614). Although substantial heterogeneity was noted, no evidence of publication bias was observed. Conclusion These results highlight the utility of structured exercise as a nonpharmacological tool to improve autonomic cardiovascular function in older adults, with potential implications for reducing cardiovascular risk and promoting healthy ageing.
体育锻炼可增强心血管自主神经功能;然而,目前在老年人群中的证据仍然存在争议。目的本系统综述和荟萃分析旨在探讨体育锻炼对老年人自主心血管功能的影响。方法按照PRISMA 2020指南,于2025年3月12日在PubMed、Web of Science、Scopus和ScienceDirect进行系统文献检索。两名独立审稿人应用PICOS模型筛选了2010年以来发表的随机对照试验(RCTs),这些试验研究了运动干预对老年人自主心血管功能的影响。采用PEDro量表评估方法学质量。采用经验贝叶斯方法,通过随机效应模型计算标准化平均差(SMD)和95%置信区间(CI)。该系统评价和荟萃分析已在PROSPERO注册(CRD420250651364)。结果meta分析共纳入15项rct。运动干预显著增加了连续差异的均方根(RMSSD) (SMD 0.636, 95%可信区间[CI] 0.014-1.258, p = 0.045),显著降低了低频/高频(LF/HF)比(SMD - 0.506, 95% CI - 0.954 ~ - 0.057, p = 0.027)。正态到正态区间的标准差(SDNN) (SMD为0.718,95% CI为- 0.120至1.557,p = 0.093)或气压反射敏感性(SMD为- 0.137,95% CI为- 0.670至0.396,p = 0.614)未发现显著影响。虽然注意到实质性的异质性,但没有观察到发表偏倚的证据。这些结果强调了有组织的锻炼作为一种非药物工具的效用,可以改善老年人的自主心血管功能,具有降低心血管风险和促进健康老龄化的潜在意义。
{"title":"Effects of Exercise on Autonomic Cardiovascular Function in Older Adults: A Systematic Review and Meta-Analysis","authors":"Paula Etayo-Urtasun, Mikel Izquierdo, Mikel L. Sáez de Asteasu","doi":"10.1007/s40279-025-02357-5","DOIUrl":"https://doi.org/10.1007/s40279-025-02357-5","url":null,"abstract":"Background Physical exercise has been proposed to enhance cardiovascular autonomic function; however, current evidence in older populations remains controversial. Objective This systematic review and meta-analysis aimed to examine the effects of physical exercise on autonomic cardiovascular function in older adults. Methods A systematic literature search was conducted in PubMed, Web of Science, Scopus, and ScienceDirect on March 12, 2025, following PRISMA 2020 guidelines. Two independent reviewers applied the PICOS model to screen randomised controlled trials (RCTs) published since 2010 that investigated the effects of exercise interventions on autonomic cardiovascular function in older adults. Methodological quality was assessed using the PEDro scale. Standardised mean differences (SMD) and 95% confidence intervals (CI) were calculated through random effects models using the Empirical Bayes method. This systematic review and meta-analysis was registered in PROSPERO (CRD420250651364). Results Fifteen RCTs were included in the meta-analysis. Exercise interventions significantly increased the root mean square of the successive differences (RMSSD) (SMD 0.636, 95% confidence interval [CI] 0.014–1.258; <jats:italic>p</jats:italic> = 0.045) and significantly decreased the low-frequency / high-frequency (LF/HF) ratio (SMD − 0.506, 95% CI − 0.954 to − 0.057; <jats:italic>p</jats:italic> = 0.027). No significant effects were found for the standard deviation of normal-to-normal intervals (SDNN) (SMD 0.718, 95% CI − 0.120 to 1.557; <jats:italic>p</jats:italic> = 0.093) or baroreflex sensitivity (SMD − 0.137, 95% CI − 0.670 to 0.396; <jats:italic>p</jats:italic> = 0.614). Although substantial heterogeneity was noted, no evidence of publication bias was observed. Conclusion These results highlight the utility of structured exercise as a nonpharmacological tool to improve autonomic cardiovascular function in older adults, with potential implications for reducing cardiovascular risk and promoting healthy ageing.","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"13 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145553302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1007/s40279-025-02347-7
Saurabh Satija,Todd W Mitchell,Ryan Anthony,Gregory E Peoples,John A Sampson
Exercise triggers a proportional inflammatory response that is crucial for muscle fiber repair and adaptation. However, excessive or chronic inflammation can delay recovery and increase injury risk. Biomarkers such as creatine kinase and interleukins are commonly used to assess muscle damage and inflammation, respectively, but they have limitations in specificity and sensitivity. However, lipid mediators that signal all inflammatory events with distinct roles in pro-inflammatory, anti-inflammatory, and pro-resolving phases could provide a more complete understanding of the inflammatory response to exercise. In this review, we discuss the limitations of current biomarkers and the potential of lipid mediators to theoretically offer more precise insights into the inflammatory processes following exercise. Further research is needed to establish standardized protocols for measuring lipid mediators and to understand their temporal dynamics in relation to inflammation and recovery. This knowledge could lead to improved strategies for monitoring and enhancing recovery in athletes.
{"title":"From Strain to Repair: A Targeted Review of Lipid Mediators Driving the Inflammatory Cascade Following Exercise.","authors":"Saurabh Satija,Todd W Mitchell,Ryan Anthony,Gregory E Peoples,John A Sampson","doi":"10.1007/s40279-025-02347-7","DOIUrl":"https://doi.org/10.1007/s40279-025-02347-7","url":null,"abstract":"Exercise triggers a proportional inflammatory response that is crucial for muscle fiber repair and adaptation. However, excessive or chronic inflammation can delay recovery and increase injury risk. Biomarkers such as creatine kinase and interleukins are commonly used to assess muscle damage and inflammation, respectively, but they have limitations in specificity and sensitivity. However, lipid mediators that signal all inflammatory events with distinct roles in pro-inflammatory, anti-inflammatory, and pro-resolving phases could provide a more complete understanding of the inflammatory response to exercise. In this review, we discuss the limitations of current biomarkers and the potential of lipid mediators to theoretically offer more precise insights into the inflammatory processes following exercise. Further research is needed to establish standardized protocols for measuring lipid mediators and to understand their temporal dynamics in relation to inflammation and recovery. This knowledge could lead to improved strategies for monitoring and enhancing recovery in athletes.","PeriodicalId":21969,"journal":{"name":"Sports Medicine","volume":"75 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145545034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}