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2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA)最新文献

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Preliminary evaluation of a wireless remote monitoring system for home mechanical ventilation 家用机械通风无线远程监测系统的初步评价
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533706
L. Battista, G. Summa
Patients who have acute respiratory failure and who have not responded to other treatment options can benefit from using a treatment, called Home Mechanical Ventilation. In order to allow the remote patient monitoring, in the last few years several tele-monitoring systems have been introduced, but most of them usually do not allow real-time services, are based on a wired connection, have their own proprietary serial communication protocol implemented and some ventilation parameters are not always measured. In order to reduce the above quoted drawbacks, in this work we report the development of a novel wireless remote monitoring system for long-term home-based ventilation therapy. The proposed system is based on the real-time monitoring of the main physical quantities involved during home-care ventilation and is developed in order to allow observation of different remote therapy units everywhere located in different places of a city, region or country. The developed remote patient monitoring system has been successfully tested by means of spirometric trials and, especially, by means of experimental tests carried out with pulmonary ventilators typically used to support sick patients.
患有急性呼吸衰竭且对其他治疗方案没有反应的患者可以使用一种称为家庭机械通气的治疗方法。为了实现患者的远程监护,近年来出现了几种远程监护系统,但大多数系统通常不支持实时服务,基于有线连接,实现自己专有的串行通信协议,并且一些通气参数并不总是测量。为了减少上述缺点,在这项工作中,我们报告了一种用于长期家庭通气治疗的新型无线远程监测系统的开发。拟议的系统基于对家庭护理通风过程中涉及的主要物理量的实时监测,并开发用于观察位于城市、地区或国家不同地方的不同远程治疗单元。开发的远程患者监测系统已通过肺活量测定试验,特别是通过通常用于支持病人的肺呼吸机进行的实验测试,成功地进行了测试。
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引用次数: 3
The measurement of global shortening as a new parameter to evaluate bone specimen response to uniaxial loading: Length change measurement for bone tissue specimens 测量整体缩短作为评估骨标本对单轴载荷响应的新参数:骨组织标本长度变化测量
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533726
E. Rizzuto, Enrica Urciuoli, B. Peruzzi, Z. Prete
Mechanical load is nowadays considered one of the factor mainly affecting bone tissue properties, both as architecture and functionality. Mechanotransduction is the capability of cells to translate mechanical stresses into biochemical signals, and several studies performed on mouse models demonstrated that also bone cells show a high responsiveness to mechanical stimuli. To date, bone cells mechanotransduction is mainly investigated in animal models, by the use of organ cultures or directly in vivo, and the actual strains induced by the external loads are measured through the use of micro strain gauges placed on the tibia mid-diaphysis. With the aim of proposing a new parameter to come along with the measurement of the actual strains, we exploited the capability of tibial global shortening to return useful information. We employed an experimental system based on a dual mode actuator/transducer with an adequate force range and a high length resolution to retrieve the small shortening of the bone specimens subjected to uniaxially load. Preliminary results showed that the tibia global shortening has a linear relationship with the increasing load, in the range of force usually used in these studies. In addition, the tibia global shortening showed the capability of gathering the changes occurring in the bone tissue mechanical properties when subjecting the specimens to loading signals of different frequencies. When tested with load signals of a frequency equal or higher than 1 Hz, in fact, the bone specimens showed a more rigid behavior. At 9 N of load, for example, the average value of tibia global shortening measured at 0.1 Hz is, on average, 18 % higher than when measured at all the other tested frequencies.
目前,机械载荷被认为是影响骨组织结构和功能的主要因素之一。机械转导是细胞将机械应力转化为生化信号的能力,在小鼠模型上进行的几项研究表明,骨细胞对机械刺激也表现出高度的反应性。迄今为止,骨细胞的机械转导主要是在动物模型中,通过器官培养或直接在体内进行研究,并且通过放置在胫骨中骨干上的微应变计来测量外部载荷引起的实际应变。为了提出一个新的参数来测量实际应变,我们利用胫骨整体缩短的能力来返回有用的信息。我们采用了一种基于双模致动器/换能器的实验系统,该系统具有足够的力范围和高长度分辨率来检索受单轴载荷作用下骨标本的小缩短。初步结果表明,胫骨整体缩短与载荷的增加呈线性关系,在这些研究中通常使用的力范围内。此外,胫骨整体短缩显示了在不同频率加载信号作用下骨组织力学性能变化的收集能力。事实上,当频率等于或高于1hz的载荷信号进行测试时,骨试件表现出更强的刚性行为。例如,在9牛载荷下,在0.1 Hz下测量的胫骨整体缩短的平均值比在所有其他测试频率下测量的平均值平均高18%。
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引用次数: 1
Ultrasound estimation of pleural effusion in geriatric patients 老年患者胸腔积液的超声诊断
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533735
Mauro Cerquitella, P. Saccomandi, E. Schena, S. Silvestri, S. Scarlata, R. Giua
The pleural fluid is a viscous substance between the two pleural layers of the lungs, important in the respiratory mechanics. A pleural effusion (PE) is an excess of pleural fluid in the pleural cavity, caused by several pathologies (e.g., pulmonary embolism, cancer, and infections). Because of its incidence, PE identification and quantification are important to lead the clinician in the selection of the optimal therapeutic strategy. PE volume can be estimated by invasive (quantitative) and non-invasive (qualitative) approaches. Invasive methods provide accurate measurement of PE volume and utilize Computed Tomography (CT) imaging and thoracentesis. Non-invasive methods are based on Ultrasound (US) imaging and are able to identify the PE, but do not quantify its volume. Aiming to spare the patients from risks due to X-ray exposure and invasiveness of thoracentesis, a non-invasive approach for the estimation of PE is coveted. The aim of this study is the feasibility assessment of a simple and affordable model for the quantification of PE through US images. Two US scans are performed to measure: the height of PE column (hPEUS) and the area of the effusion (aPEUS) in correspondence of half hPEUS. The proposed model estimates the PE volume (PEVUS) by multiplying hPEUS and aPEUS, based on cylindrical approximation. PEVUS are compared with PE volumes estimated by CT scans (PEVct), achieved within 24 h from the US exam. The model was successfully tested on 7 patients for PE volumes ranging from 70 mL to 550 mL. The good agreement between PEVus and PEVct volumes is witnessed by the slope of the best fitting line (0.988) and the high correlation coefficient (R=0.99). The two measurements are also compared by Bland-Altman plot, which provides a mean of difference of 1.7 mL and limits of agreement of -32.5 mL and +36.0 mL. The findings of this work show that the proposed model can be a valid tool for the estimation of PE volume by means of US exam. An important advantage of this model is the possibility to quantify PE by the measurements of only two parameters. This approach is not time consuming, hence it can be easily implemented in clinical routine.
胸膜液是介于肺两层胸膜之间的一种粘性物质,在呼吸力学中很重要。胸腔积液(PE)是由多种病理(如肺栓塞、癌症和感染)引起的胸腔积液过多。由于其发病率高,PE的鉴定和量化对于指导临床医生选择最佳治疗策略非常重要。PE体积可以通过侵入性(定量)和非侵入性(定性)方法来估计。侵入性方法提供准确的PE体积测量,并利用计算机断层扫描(CT)成像和胸腔穿刺。非侵入性方法基于超声(US)成像,能够识别PE,但不能量化其体积。为了避免患者因x线暴露和胸穿刺的侵入性所带来的风险,一种无创的PE评估方法是人们所渴望的。本研究的目的是可行性评估一个简单的和负担得起的模型,量化PE通过美国图像。进行两次超声扫描来测量:PE柱的高度(hPEUS)和积液的面积(aPEUS)对应于半hPEUS。该模型基于圆柱形近似,通过hPEUS和aPEUS相乘来估计PE体积(PEVUS)。将PEVUS与CT扫描(PEVct)估计的PE体积进行比较,PEVct是在超声检查后24小时内获得的。该模型成功地对7例患者的PE体积进行了测试,范围从70 mL到550 mL。最佳拟合线斜率为0.988,相关系数高(R=0.99), PEVus与PEVct体积吻合良好。这两个测量结果也通过Bland-Altman图进行了比较,其提供了1.7 mL的平均差异和-32.5 mL和+36.0 mL的一致限。这项工作的发现表明,所提出的模型可以是通过US检查估计PE体积的有效工具。该模型的一个重要优点是可以通过仅测量两个参数来量化PE。该方法耗时短,易于在临床常规中实施。
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引用次数: 3
Practical interest of in vivo reflectance confocal microscopy quantification of cutaneous vascular flow during iloprost treatment 在伊洛前列素治疗期间,体内反射共聚焦显微镜对皮肤血管流量定量的实际意义
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533790
C. Jaffelin, E. Cinotti, J. Perrot, B. Labeille, F. Cambazard, L. Tognetti, P. Rubegni, J. Pittet
Introduction: iloprost is a recommended treatment for several vascular diseases such as severe Raynaud's syndrome and digital ulcers in Systemic Sclerosis (SS). In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging tool that can evaluate cutaneous microcirculation. The goal of this study was to observe, in real time, the effect of iloprost on cutaneous microcirculation by using RCM. Material and method: Five patients with microvascular diseases that needed iloprost were included. Administration speed started at 0.5 ng/kg/min until the maximum tolerated dosage. Recordings of capillary flow were done using RCM before treatment and at each change in the drug dosage. Results: The blood flow of the five patients demonstrated a significant increase from the dosage of 0.5 ng/kg/min. This significant variation did not exist at higher dosage. Discussion: This study suggests a precocious effect of iloprost in increasing the cutaneous vascular flow; this effect was not enhanced at higher drug dosage. Monitoring cutaneous capillary flow by in vivo RCM could then be of interest in optimizing iloprost dosage. This procedure will likely reduce the side effects of iloprost that are dose-dependent.
简介:伊洛前列素是几种血管疾病的推荐治疗药物,如严重雷诺综合征和系统性硬化症(SS)中的数字溃疡。体内反射共聚焦显微镜(RCM)是一种评估皮肤微循环的非侵入性成像工具。本研究的目的是通过RCM实时观察伊洛前列素对皮肤微循环的影响。材料与方法:纳入5例需要伊洛前列素治疗的微血管疾病患者。起始给药速度为0.5 ng/kg/min,直至最大耐受剂量。在治疗前和每次药物剂量变化时,用RCM记录毛细血管流量。结果:从0.5 ng/kg/min剂量开始,5例患者血流量明显增加。在较高的剂量下,这种显著的变化不存在。讨论:这项研究表明伊洛前列素在增加皮肤血管流量方面具有早熟作用;在较高的药物剂量下,这种效果没有增强。通过体内RCM监测皮肤毛细血管流量可以优化伊洛前列素的剂量。这种方法可能会减少依洛前列素剂量依赖性的副作用。
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引用次数: 0
Performances of heated wire humidifiers during adult mechanical ventilation: Estimation of the amount of condensation 热丝加湿器在成人机械通风中的性能:冷凝量的估计
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533698
Chiara Losquadro, P. Saccomandi, C. Massaroni, E. Schena
During invasive artificial ventilation is crucial to heat and to humidify gases delivered to patients. Heated Wire Humidifiers (HWHs) are largely used to perform this task. Their performances are strongly influenced by ventilatory settings (e.g., Minute Volume-MV- and respiratory frequency-f-), and environmental conditions. An important concern in case of over-humidification is the formation of water condensation within the breathing circuit, which increases the risk for pulmonary infection and the occlusion of endotracheal tube. Several studies assessed the water condensation by qualitative scales. This work aims to estimate the mass of condensed vapor within the breathing circuit at different MV and f, covering all the conditions used during adult ventilation. Results show that the condensed vapor increases with both MV and f. Moreover, preliminary experiments show that the condensation decreases with room temperature. The substantial amount of condensation confirms the weaknesses of the control strategy mostly implemented on commercial HWHs. These data can be helpful to figure out the impact of ventilatory settings on HWHs performances and to find out novel solutions to improve them.
在有创人工通气期间,给病人加热和加湿气体是至关重要的。热丝加湿器(HWHs)主要用于完成此任务。它们的性能受到通气设置(例如,分钟音量- mv -和呼吸频率-f-)和环境条件的强烈影响。在过度加湿的情况下,一个重要的问题是在呼吸回路中形成冷凝水,这增加了肺部感染和气管内管闭塞的风险。一些研究通过定性尺度评估了水的凝结。这项工作旨在估计在不同MV和f下呼吸回路内冷凝蒸汽的质量,涵盖成人通气期间使用的所有条件。结果表明,冷凝蒸汽量随MV和f的增大而增大,且初步实验表明,冷凝量随室温的升高而减小。大量的冷凝水证实了商用HWHs大多采用的控制策略的弱点。这些数据有助于了解通风设置对HWHs性能的影响,并找到改善HWHs性能的新解决方案。
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引用次数: 4
PCA based analysis of external respiratory motion using an RGB-D camera 基于PCA的RGB-D摄像机外呼吸运动分析
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533811
Udaya Wijenayake, Soon-Yong Park
Human respiration induces considerable external and internal motion in the thoracic and abdominal regions. Tracking and modeling of this motion is an important task for accurate treatment planning and dose calculation during external beam radiotherapy. Inaccurate motion tracking can cause severe issues such as errors in target/normal tissue delineation and increment in the volume of healthy tissues exposed to high doses. Different methods have been introduced to model the respiratory motion, but most of them use wearable markers or surgical node implanting techniques, which are inconvenient to patients. In this paper, we experiment the feasibility of using an RGB-D camera along with Principal Component Analysis (PCA) to track and model the subject-specific external respiratory motion. Marker-based depth frame registration technique is also introduced to limit the measuring area into an anatomically consistent region during the treatment. We evaluate the accuracy of the proposed method using a Spirometer and a laser line scanner.
人体呼吸在胸腹区域引起相当大的内外运动。这种运动的跟踪和建模是精确的治疗计划和剂量计算的重要任务。不准确的运动跟踪可能导致严重的问题,例如目标/正常组织描绘的错误以及暴露于高剂量的健康组织体积的增加。目前已有不同的呼吸运动建模方法,但大多采用可穿戴式标记或手术节点植入技术,给患者带来不便。在本文中,我们实验了使用RGB-D相机和主成分分析(PCA)来跟踪和建模受试者特定的外部呼吸运动的可行性。还引入了基于标记的深度帧配准技术,以在治疗期间将测量区域限制为解剖一致的区域。我们使用呼吸计和激光线扫描仪来评估所提出方法的准确性。
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引用次数: 2
The phase amplitude coupling to assess brain network system integration 相幅耦合评价脑网络系统集成
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533783
P. Marconi, E. Pessa, M. P. Penna, R. Tambelli
Brain Dynamics seems to be the most actual approach to the brain responses to external stimuli. Even if Event Related Potentials can be detected, the EEG band power perturbation and the Phase Amplitude Coupling (PAC) seems to be the most appropriate way to assess such a brain dynamics. In this study 13 borderline subject with a child maltreatment history were studied in respect to 11 controls without any psychopathologic history. Both group were exposed to the Odd Ball Paradigm and related EEG activities were recorded from 256 electrodes on the scalp. The maltreated people resulted in higher levels of dystimia and worst behavioral performances as well as with a higher emotional dysregulation. Electro-physiological correlates were assessed with a different brain dynamics detected in maltreated group when target stimuli were presented. The results confirm the importance of the PAC and of the assessment of Cross Frequency Modulation (CfM). The results support the role of such a method for clinical diagnostics and suggest an explanation for the use of brain entrainment effect for therapeutic interventions. More over the presence of these oscillatory phenomena and this kind of brain dynamics suggest the compatibility of such results with scale free structures in the brain network architectures, where a small number of hubs, with high connection degrees, are embedded within a large assembly of neurons with low connection degrees.
大脑动力学似乎是研究大脑对外部刺激反应的最实际的方法。即使可以检测到事件相关电位,EEG频带功率扰动和相幅耦合(PAC)似乎是评估这种脑动力学的最合适的方法。在这项研究中,13名有儿童虐待史的边缘受试者与11名没有任何精神病理史的对照进行了研究。两组均暴露于Odd Ball范式,并从头皮上的256个电极记录相关的脑电图活动。受虐待的人会出现更高程度的躁动障碍和最糟糕的行为表现,以及更高程度的情绪失调。当目标刺激出现时,电生理相关性通过在受虐待组中检测到的不同脑动力学来评估。结果证实了PAC和交叉频率调制(CfM)评估的重要性。研究结果支持了这种方法在临床诊断中的作用,并对脑夹带效应用于治疗干预提出了解释。更重要的是,这些振荡现象的存在和这种大脑动力学表明,这种结果与大脑网络架构中的无标度结构是相容的,在大脑网络架构中,少量高连接度的枢纽嵌入在低连接度的大量神经元中。
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引用次数: 0
A novel head gesture based interface for hands-free control of a robot 一种新颖的基于头部手势的机器人免提控制界面
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533744
Anja Jackowski, Marion Gebhard, A. Gräser
Within this work a novel head gesture based interface for hands-free control of a collaborative robot is developed and evaluated. Based on previous work, robot control is divided into several control groups for intuitive head motion based control. The switching commands to select and switch between these robot control groups are given by four gestures performed with head movements. The head movements were measured using a nine-axis inertial measurement unit. The control of a robot with the novel interface was evaluated objectively as well as subjectively. The objective evaluation contains the measurement of time needed for the given control task and the number of trials for switching between the different groups of robot control. The subjective evaluation was carried out with a questionnaire. All subjects were able to perform the given task of controlling a robot arm with the head gesture based interface.
在这项工作中,开发并评估了一种新的基于头部手势的协作机器人免提控制界面。在前人工作的基础上,将机器人控制分为几个控制组,实现基于直观头部运动的控制。在这些机器人控制组之间选择和切换的切换命令是通过头部运动的四个手势来给出的。头部运动采用九轴惯性测量装置进行测量。对具有新界面的机器人的控制进行了客观和主观的评价。客观评价包括测量完成给定控制任务所需的时间和在不同机器人控制组之间切换的试验次数。主观评价采用问卷方式进行。所有的受试者都能够完成给定的任务,即通过基于头部手势的界面来控制机械手臂。
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引用次数: 21
Do elderly people fake in the assessment of their mental health? 老年人在心理健康评估中作假吗?
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533771
P. Hitchcott, M. C. Fastame, M. P. Penna, M. Agus
Several studies show that both positive mental health in late adulthood and longevity are positively associated with indices of psychological well-being (e.g., life satisfaction, coping) and negatively associated with signs of depression. However, the self-assessment of mental health in the elderly may be biased by social desirability as they attempt to present themselves more positively in order to impress the interlocutor and preserve their social image. A primary aim of the current study was to explore whether social desirability influenced self-assessment of depression in a sample of cognitively healthy elderly people residing in Sardinia, an Italian isle characterized by higher longevity indexes. Moreover, it was investigated the relationship between perceived physical health and depression and whether this relationship was impacted by social desirability. Each participant was presented a battery of inventories including measures of metacognitive efficiency, subjective well-being, depression, socially desirability. Overall, An ANCOVA and a path analysis highlighted the role played by social desirability on participants' self-assessment of mental health. The implications of these findings with respect to current research trends and clinical practice will be discussed.
几项研究表明,成年后期的积极心理健康和长寿与心理健康指数(如生活满意度、应对能力)呈正相关,与抑郁迹象呈负相关。然而,老年人对心理健康的自我评估可能会受到社会期望的影响,因为他们试图更积极地表现自己,以给对话者留下深刻印象,并保持他们的社会形象。当前研究的一个主要目的是探索社会期望是否会影响居住在撒丁岛的认知健康老年人的抑郁自我评估,撒丁岛是意大利一个以长寿指数较高为特征的岛屿。此外,我们还调查了感知身体健康与抑郁之间的关系,以及这种关系是否受到社会期望的影响。每个参与者都有一系列的量表,包括元认知效率、主观幸福感、抑郁、社会期望。总体而言,ANCOVA和路径分析强调了社会期望对参与者心理健康自我评估的作用。这些发现对当前研究趋势和临床实践的影响将被讨论。
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引用次数: 5
Quantitative assessment of gait in elderly people affected by Parkinson's Disease 老年帕金森病患者步态的定量评估
Pub Date : 2016-05-15 DOI: 10.1109/MeMeA.2016.7533772
F. Corona, M. Pau, M. Guicciardi, Mauro Murgia, Roberta Pili, Carlo Casula
Assessment of gait abnormalities in individuals affected by Parkinson's Disease (PD) is essential in evaluating the disease progression and the effectiveness of pharmacologic and rehabilitative treatments. However, in the clinical routine qualitative and subjective methods are often employed to this aim, despite the availability of sophisticated equipment able to supply accurate and detailed quantitative information. In this study, we propose the use of motion capture systems based on optoelectronic stereophotogrammetry to investigate the main spatio-temporal and kinematics parameters of gait in a cohort of 28 individuals with PD of age > 60. In particular, we aimed to describe the gait kinematics on the basis of concise measures (Gait Profile Score, GPS and Gait Variable Score, GVS) obtained from a quantitative three-dimensional analysis of gait. The results show that peculiar features are identifiable, especially in terms of functional limitations of hip and knee joints and confirm the validity of the GPS approach to describe the deviations from a physiologic gait pattern. Such method might be very useful in helping clinicians to detect even subtle changes in gait patterns (that would be impossible to observe with other techniques) consequent to either pharmacologic or rehabilitative treatments.
评估帕金森病(PD)患者的步态异常对于评估疾病进展以及药物和康复治疗的有效性至关重要。然而,在临床常规中,通常采用定性和主观方法来达到这一目的,尽管有先进的设备能够提供准确和详细的定量信息。在这项研究中,我们提出使用基于光电立体摄影测量的运动捕捉系统来研究28名年龄> 60岁的PD患者的主要时空和运动学参数。特别是,我们的目标是基于从步态定量三维分析中获得的简明测量(步态轮廓评分,GPS和步态变量评分,GVS)来描述步态运动学。结果表明,特殊的特征是可识别的,特别是在髋关节和膝关节的功能限制方面,并证实了GPS方法描述偏离生理步态模式的有效性。这种方法在帮助临床医生检测由于药物或康复治疗而导致的步态模式的细微变化(这是不可能用其他技术观察到的)方面可能非常有用。
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引用次数: 18
期刊
2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA)
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