Widespread use of the atypical antipsychotic quetiapine has resulted in the increased possibility of its interaction with other concurrently administered psychotropic agents. For example, the antiepileptic lamotrigine, commonly prescribed for the management of bipolar disorder, has a potential drug-drug interaction with co-administered quetiapine..
A population-based study conducted in Taiwan has found that use of benzodiazepines during pregnancy increases risk of miscarriage. This increased risk persisted in analyses that were adjusted for multiple confounding variables, the investigators reported. Results were published online Dec. 27, 2023, in JAMA Psychiatry.
A single 25-mg dose of psilocybin resulted in improvement in depressive symptoms in all 15 participants in an open-label nonrandomized trial enrolling adults with bipolar II disorder. Twelve of the 15 participants met response and remission criteria at the study's 12-week endpoint.
Rivastigmine tartrate Rivastigmine transdermal system (generic) — Exelon patch (brand)
Synthetic glucocorticoids, such as dexamethasone and prednisolone, are commonly used in the treatment of patients with inflammatory conditions and autoimmune disorders. However, the multiple physiological effects that glucocorticoids exert can often result in short- and long-term adverse drug reactions, including neuropsychiatric adverse events. Despite the widespread use of glucocorticoids, the prevalence of neuropsychiatric adverse events with these medications, while believed to be common, has not been rigorously quantified.
A comparative effectiveness study using a U.S. commercial insurance database has found small increases in risk of mortality and other adverse outcomes when benzodiazepine treatment is discontinued in long-term users. Mortality risk was higher in subgroups of discontinuers both with and without exposure to opioids.
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