Memantine (generic) Namenda (brand)
A retrospective cohort study has found that while esketamine is effective in combination with an antidepressant in patients with treatment-resistant depression, effects differ based on antidepressant class. Patients receiving esketamine with a serotonin-norepinephrine reuptake inhibitor (SNRI) showed improvement on more measures in comparison with the combination of esketamine and a selective serotonin reuptake inhibitor (SSRI). Study results were published online April 2, 2025, in JAMA Psychiatry.
Smokers receiving the plant-based alkaloid cytisinicline with behavioral support showed significantly higher smoking abstinence rates compared with those receiving placebo with behavioral support, a Phase 3 replication trial has found. The incidence of adverse events was similar between the cytisinicline and placebo groups.
A systematic review and meta-analysis that included 12 studies has found that antidepressant treatment for depression occurring after a myocardial infarction (MI) improved depressive symptoms without increasing patients' cardiac risk. The meta-analysis found an association between antidepressant treatment and reduced risk of MI recurrence. Results were published online April 23, 2025, in BMC Psychiatry.
Research has suggested a possible link between antidepressants and increased risk of type 2 diabetes (Salvi et al., 2017). A higher prevalence of diabetes has also been reported in patients with schizophrenia (De Hert et al., 2009). Management of concurrent diabetes and psychiatric disorders could lead to polypharmacy, with risks of increased adverse drug effects and potential drug-drug interactions.
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