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A Comprehensive Review on Role of Nutrition in Management of Breast Cancer 营养在乳腺癌治疗中的作用综述
Pub Date : 2022-10-10 DOI: 10.21048/ijnd.2022.59.4.30271
S. K, S. S.
Breast cancer (BC) is the most frequent malignancy in women and the second most common cause of cancer worldwide. There’s a lot of evidence that lifestyle factors including food, body weight, and physical activity are linked to a higher risk of breast cancer. Several bioactive food ingredients, including both essential and non-essential nutrients, can change gene expression profiles. Consequently, nutrigenomics provides information on the effects of consumed nutrients and other food components on gene regulation and transcription factors, i.e., diet-gene interaction, to find dietetic components that are beneficial or damaging to one’s health. Biological processes such as epigenetics, transcriptomics, and proteomics influence nutritional genomics (nutrigenomics), which is the junction of health, food, and genomics. As a result, it will help to determine unique nutritional requirements based on a person’s genetic composition (personalized diet), and also the link between diet and chronic diseases such as cancer, opening up new avenues for a better understanding of the impacts of breast cancer and its management. Chemotherapy or radiotherapy patients with BC experience a variety of symptoms that influence their quality of life. According to research studies on nutritional therapy during BC treatment, nutritional counseling and supplementation with certain dietary elements may be useful in reducing drug-induced side effects and increasing therapeutic efficacy. As a result, nutritional control in BC patients may be considered a critical component of a multimodal treatment strategy. The goal of this review is to give a summary of the existing research on the association between dietary variables and BC.
乳腺癌(BC)是女性中最常见的恶性肿瘤,也是全球第二大常见癌症原因。有很多证据表明,包括食物、体重和体育活动在内的生活方式因素与患乳腺癌的高风险有关。几种生物活性食品成分,包括必需和非必需营养素,可以改变基因表达谱。因此,营养基因组学提供了关于所消耗的营养素和其他食物成分对基因调控和转录因子的影响的信息,即饮食-基因相互作用,以发现对健康有益或有害的饮食成分。生物过程,如表观遗传学,转录组学和蛋白质组学影响营养基因组学(营养基因组学),这是健康,食品和基因组学的交界处。因此,它将有助于根据一个人的基因组成(个性化饮食)确定独特的营养需求,也有助于确定饮食与癌症等慢性疾病之间的联系,为更好地了解乳腺癌的影响及其管理开辟新的途径。化疗或放疗的BC患者会经历各种影响其生活质量的症状。根据对BC治疗期间营养治疗的研究,营养咨询和补充一定的膳食元素可能有助于减少药物引起的副作用,提高治疗效果。因此,对BC患者的营养控制可能被认为是多模式治疗策略的关键组成部分。本综述的目的是对饮食变量与BC之间关系的现有研究进行总结。
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引用次数: 0
Development and Evaluation of Sorghum and Little Millet Based Ladoo 高粱和小小米拉度的开发与评价
Pub Date : 2022-10-10 DOI: 10.21048/ijnd.2022.59.4.29839
J. P., K. Waghray
Millets are called Nutri-cereals which are nutritionally superior when compared to that of staple cereals like rice and wheat and have numerous health benefits in improving the overall health of consumers. In spite of their multiple health benefits, millets are only consumed by people who are of low income group. The present study was done to develop and analyse the nutritional value, physiochemical properties and shelf life studies of millet ladoo as readymade snack which is developed through standardization process by blending the major millet i.e Sorghum (Sorghum bicolor) and minor millet i.e. Little millet (Panicum sumatrense), Tamarind kernel powder (Tamarindus indica), Cardamom (Elettaria cardamomum), Bengal gram flour (chick pea) ghee and palm jaggery powder. Millet ladoo that was highly accepted by thirty semi-trained panel members through nine point hedonic scale by formulating sorghum, little millet and other ingredients showed total carbohydrates, protein, fat and fibre about 55.68, 7.54, 20.2 and 2.88% respectively. The sensory evaluation of the acceptable ladoo revealed that the texture, appearance, color, aroma, taste and all quality parameters were in acceptable range during storage. The product shelf life was found to be 30 days with addition of preservative i.e. food grade potassium sorbate followed by packaging of millet ladoo by using polyethylene terephthalate tray as primary packaging material and multilayer plastic laminate pouch as a secondary packaging material. The shelf life of millet ladoo was 15 days without addition of preservative when packed in polyethylene terphthalate tray that was placed in multilayer plastic laminate pouch at room temperature. The sensory parameters of millet ladoo packed in polyethylene terphthalate tray without multilayer plastic laminate pouch was not acceptable for further studies. The work done was an attempt to develop value added products of major and minor millets and increase consumption of millet products for better nutrition of consumers.
小米被称为营养谷物,与大米和小麦等主食谷物相比,它的营养价值更高,对改善消费者的整体健康有许多好处。尽管小米有多种健康益处,但只有低收入人群才会食用小米。本研究的目的是开发和分析小米ladoo作为即食小吃的营养价值,理化性质和保质期研究。小米ladoo是通过标准化过程开发的,通过混合主要小米,如高粱(Sorghum bicolor)和次要小米,如小小米(Panicum sumatrense),罗望子仁粉(Tamarindus indica),小豆蔻(Elettaria cardamomum),孟加拉克面粉(鹰嘴豆)酥油和棕榈粗粉。由高粱、小小米等配料组成的小米ladoo,通过9点享乐量表得到30位半训练小组成员的高度认可,其碳水化合物、蛋白质、脂肪和纤维的总含量分别约为55.68%、7.54%、20.2%和2.88%。可接受度感官评价结果表明,可接受度贮藏期间的质地、外观、颜色、香气、口感等各项品质参数均在可接受范围内。在添加食品级山梨酸钾防腐剂的情况下,产品的保质期为30天,然后以聚对苯二甲酸乙二醇酯托盘为主要包装材料,多层塑料层压袋为次要包装材料对小米ladoo进行包装。在室温下,用聚对苯二甲酸乙二醇酯托盘包装,置于多层塑料层压袋中,不添加防腐剂的小米拉度保质期为15天。用聚对苯二甲酸乙二醇酯托盘包装的小米拉度的感官参数不适合进一步的研究。这一工作是为了开发大小米和小小米的附加值产品,增加小米产品的消费量,提高消费者的营养水平。
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引用次数: 0
Effect of Supplementation of Nutribar on the Physical Performance and Biochemical Parameters of Women Sprinters during Covid-19 Pandemic 新冠肺炎大流行期间补充营养棒对女子短跑运动员体能和生化指标的影响
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.30363
Abhirami Sivaprasad, K. S.
Several factors contribute to success in sport, and diet is a key component. An athlete’s dietary requirements depend on several aspects, including the sport, the athlete’s goals, the environment and practical issues. The importance of individualized dietary advice has been increasingly recognized, including day-to-day dietary advice and specific advice before, during and after training and/or competition. Athletes use a range of dietary strategies to improve performance, by maximizing glycogen stores. Carbohydrate intake during exercise maintains high levels of carbohydrate oxidation, prevents hypoglycemia, and has a positive effect on the central nervous system which is facilitated for physical performances of sprinters. Dietary supplements including Nutribars enhance exercise and athletic performance in a variety of forms, including tablets, capsules, drinks, health mixes and bars. The present study aimed to assess the effect of the supplementation of developed Nutribar on the physical performance and biochemical profile of district-level women sprinters under the age group of 17-20 years. In the study, 59 sprinters (30 control group and 29 experimental groups) were identified and executed for further supplemention study, out of 140 sprinters in the age group of 17-20 y. Results revealed that the sprinters in the experimental group showed significant changes in their biochemical profile and physical performance after the supplementation of Nutribar. Hence Nutribar could be a better choice for supplementing energy for sprinters to enhance their physical performance and biochemical profile for the period of three months.
在运动中取得成功有几个因素,饮食是一个关键因素。运动员的饮食需求取决于几个方面,包括运动、运动员的目标、环境和实际问题。个性化饮食建议的重要性已得到越来越多的认识,包括日常饮食建议以及训练和/或比赛之前、期间和之后的具体建议。运动员使用一系列的饮食策略来提高表现,通过最大化糖原储存。在运动中摄入碳水化合物可以保持高水平的碳水化合物氧化,防止低血糖,对中枢神经系统有积极的影响,有利于短跑运动员的身体表现。包括Nutribars在内的膳食补充剂以各种形式增强运动和运动表现,包括片剂,胶囊,饮料,健康混合物和棒。本研究旨在评估补充营养棒对17-20岁区级女子短跑运动员体能和生化指标的影响。在本研究中,从140名17-20岁年龄组的短跑运动员中筛选出59名短跑运动员(30名对照组和29名试验组)进行补充研究。结果表明,实验组短跑运动员在补充Nutribar后,其生化指标和体能表现发生了显著变化。因此,在为期三个月的比赛中,Nutribar是短跑运动员补充能量以提高体能和生化指标的较好选择。
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引用次数: 0
Antidiabetic Activity of Bioactive Compounds in Pleurotus florida using Protein Receptors 利用蛋白受体研究佛罗里达侧耳生物活性化合物的抗糖尿病活性
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.29578
Beena Cherian, S. Jose
Diabetes Mellitus (DM) is a chronic metabolic disorder due to the defects of insulin secretion (type 1) and increased cellular resistance to insulin (type 2). Mushrooms were found to be effective for reducing diabetic complications and for decreasing the blood glucose levels. When compared to synthetic drugs, the bioactive compounds isolated from mushrooms seem to be less toxic and free of side effects. The ethanol extracts of Pleurotus florida mushroom was used for the extraction of bioactive compounds. The compounds PFEE-1 to PFEE -14 were screened for drug likeness and molecular properties. For structural molecular biology and computer -assisted drug design, molecular docking is found to be a strong tool. It has been used in an attempt to identify and to expound the mechanism of action of the bioactive compounds in Pleurotus florida with the inhibition of GPCR40, PTPBI, PPAR and DPP4 protein receptor for controlling the blood sugar level. 14 bioactive compounds screened from Pleurotus florida mushroom ethanol extract was docked with the glide software based on the drug-likeness score. Ergosterol was found to be a potent inhibitor of DPP4, GPCR40, PPAR and PTPBI when compared to other bioactive compounds.
糖尿病(DM)是由于胰岛素分泌缺陷(1型)和细胞对胰岛素抵抗增加(2型)引起的一种慢性代谢紊乱。蘑菇被发现对减少糖尿病并发症和降低血糖水平有效。与合成药物相比,从蘑菇中分离出的生物活性化合物似乎毒性更小,没有副作用。以佛罗里达侧耳菇乙醇提取物为原料,对其生物活性成分进行了提取。对化合物PFEE-1 ~ PFEE -14进行了药物相似性和分子性质的筛选。对于结构分子生物学和计算机辅助药物设计,分子对接被认为是一个强有力的工具。试图鉴定并阐明杏香菇中生物活性化合物抑制GPCR40、PTPBI、PPAR和DPP4蛋白受体控制血糖水平的作用机制。从杏叶菇乙醇提取物中筛选出14种生物活性化合物,并根据药物相似度评分与glide软件进行对接。与其他生物活性化合物相比,麦角甾醇是DPP4、GPCR40、PPAR和PTPBI的有效抑制剂。
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引用次数: 0
Determination of Total Microbial Bioload and Pathogen Testing from Bakery Products 烘焙食品中总微生物量测定及病原菌检验
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.29646
M. V., D. D, S. S., V. S., A. V
Bakery products are the most widely consumed food on the planet. Microbiological spoilage is one of the most common reasons for bakery products having a short shelf life. This study reports on isolation of microorganisms from bakery products. The study aimed to prospect the isolation of bacteria, total colony count and pathogen testing were carried out nutrient agar media and specific media. Isolation of bacteria was done using nutrient agar medium, total colony count was prosecuted by colony counting method and pathogen testing was performed using specific media like mannitol salt agar, EMB agar, cetrimide agar and bismuth sulphite agar. Biochemical characterization was executed for the obtained pathogen. It was preceded by test like indol test, MRVP test, simmon’s citrate test, catalase test, gelatinase test and TSI test. After completion of these tests it was concluded the obtained microorganism was Salmonella species.
烘焙食品是地球上消费最广泛的食品。微生物变质是烘焙食品保质期短的最常见原因之一。本研究报道了从烘焙产品中分离微生物的方法。本研究旨在对细菌的分离、菌落总数和病原菌的检测进行展望。采用营养琼脂培养基进行细菌分离,采用菌落计数法进行菌落总数计数,采用甘露醇盐琼脂、EMB琼脂、氰胺琼脂和亚硫酸铋琼脂等特定培养基进行病原菌检测。对所得病原菌进行生化鉴定。在此之前进行了吲哚试验、MRVP试验、柠檬酸盐试验、过氧化氢酶试验、明胶酶试验和TSI试验。这些试验完成后,得到的微生物为沙门氏菌。
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引用次数: 0
Evaluation of Antioxidant Potentialities of Whole Fruit Juices from Ximenia americana Linn., Vitex doniana Sweet. and Annona senegalensis Pers 美洲希门尼亚全果汁抗氧化潜力的评价。甜牡荆。和凤仙花
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.29266
Ludovic Moffo Foning, E. Fombang, Tchiegang Clergé
Ximenia americana Linn. (Olacaceae)., Vitex doniana Sweet. (Verbenaceae) and Annona senegalensis Pers. (Annonaceae) are three endemic fruit species growing in dry African savannahs. The fruits produced by these species have unique and highly appreciated organoleptic characteristics (aromas and flavors). However, their consumption is limited to the localities where they are found. In addition, the rarity of scientific information on their technological and nutritional potentials constitute an obstacle to their valorization. To bridge this gap, a comparative evaluation of the antioxidant potential of the whole fruit juices from these species was carried out. After physicochemical characterization of the fruits, anti-radical power and reducing activity of the juices were determined using DPPH, ABTS, FRAP and TAC methods. The physicochemical analyses of A. senegalensis indicated values of 7.65 ± 0.99 % (proteins), 32.81 ± 1.08 % (total sugars), 3.98 ± 0.17 % (ash) in opposite to 5.68 ± 0.17 (proteins), 42.45 ± 1.54 % (total sugars), 2.03 ± 0.2 % (ash) of X. americana and 2.97 ± 0.74 % (proteins), 33.62 ± 1.79 % (total sugars), 1.36 ± 0.19 % (ash) of V. doniana. The A. senegalensis juice had the highest total phenolic and flavonoid contents respectively 1.22 ± 0.01 and 0.36 ± 0.03 g/100 g of FW compared to X. americana (731.93 ± 2.25 and 295.58 ± 1.67 g/100 g respectively) and V. doniana (633.18 ± 1.93 and 111.09 ± 2.44 respectively). A. senegalensis and X. americana had the highest anti-radical activities by DPPH (12.50 ± 0.01) compared to V. donianaand vitamin C standard (8.33 ± 0.02). The ABTS test for the juices from V. doniana and A. senegalensis (14.28 ± 0.01) was compared to X. Americana (9.90 ± 0.01) and vitamin C standard (6.66 ± 0.02). Juices from X. americana had the highest TAC reducing capacity (570.67 ± 1.14 mg EAA / 100 g of FW) compared to V. doniana (521.15 ± 1.93) and A. senegalensis (147.78 ± 2.75). The FRAP test indicated values of 1401.04 ± 1.82 mg/100 g of FW in opposite to X. americana (798.79 ± 1.51) and V. doniana (600.19 ± 2.37). Flavonoids are strongly correlated to antioxidant activity by FRAP (r=0.86) and DPPH (r = 0.96). Tannins (r = 0.98) are strongly correlated with the TAC test.
美洲西门尼亚(铁青树科)。甜牡荆。(马鞭草科)和凤仙花。(番荔枝科)是生长在干燥的非洲大草原上的三种特有果树。这些品种生产的果实具有独特和高度赞赏的感官特征(香气和风味)。然而,它们的消费仅限于发现它们的地方。此外,关于它们的技术和营养潜力的科学资料很少,这是它们增值的一个障碍。为了弥补这一差距,对来自这些物种的整个果汁的抗氧化潜力进行了比较评估。对果实进行理化表征后,采用DPPH、ABTS、FRAP和TAC等方法测定果汁的抗自由基能力和还原活性。理化分析结果表明,塞内加尔沙蚕的蛋白质含量为7.65±0.99%、总糖含量为32.81±1.08%、灰分含量为3.98±0.17%,与美洲美洲沙蚕的蛋白质含量为5.68±0.17、总糖含量为42.45±1.54%、总糖含量为2.03±0.2%、总糖含量为2.97±0.74%、总糖含量为33.62±1.79%、总糖含量为1.36±0.19%相反。总酚和类黄酮含量分别为1.22±0.01和0.36±0.03 g/100 g FW,高于美洲葡萄(731.93±2.25和295.58±1.67 g/100 g)和唐菖蒲(633.18±1.93和111.09±2.44)。senegalensis和x.a americana对DPPH的抗自由基活性最高(12.50±0.01),高于doniana和维生素C标准(8.33±0.02)。多尼亚巴和塞内格尔巴果汁的ABTS值为14.28±0.01,美洲巴果汁的ABTS值为9.90±0.01,维生素C标准值为6.66±0.02。美洲葡萄汁对TAC的还原能力最高(570.67±1.14 mg EAA / 100 g FW),多尼亚葡萄汁(521.15±1.93)和塞内加尔葡萄汁(147.78±2.75)高于美洲葡萄汁(521.15±1.93)。FRAP测定结果显示,FW含量为1401.04±1.82 mg/100 g,与美洲弧菌(798.79±1.51)和多氏弧菌(600.19±2.37)相反。FRAP (r=0.86)和DPPH (r= 0.96)对黄酮类化合物抗氧化活性有显著影响。单宁(r = 0.98)与TAC测试密切相关。
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引用次数: 0
Priliminary Phytochemical Screening and Antimicrobial Study of Dry and Fresh Aqueous, Ethanolic and Chloroform Extracts of Rosa Indica Petals 印度蔷薇花瓣干、鲜水、醇、氯仿提取物的植物化学筛选及抗菌研究
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.29440
Nithya Sethumadhavan, Santhi Natchimuthu
Plants are a valuable source of a multitude of secondary metabolites which have been used as medicine since times. Most unarguable merit of using plants as a source of medicine is that they are low priced and readily available with very minimal side effects. The present study deals with the comparative analysis of dry and fresh aqueous, ethanolic and chloroform extracts of Rosa indica petals for its phytochemical screening. The results confirmed the presence of almost all tested secondary metabolites in aqueous and ethanolic extracts, whereas chloroform extract showed only the presence of saponins. Further study was proceeded only with dry and fresh aqueous and ethanolic extracts of Rosa indica petals for its antimicrobial activity against Gram negative bacteria including Escherichia coli (ATCC NO: 25922), Pseudomonas aeruginosa (ATCC NO: 27853) and gram positive bacteria including Staphylococcus aureus (ATCC NO: 43300), Enterococcus faecalis (ATCC NO: 29212) and Candida albicans (ATCC NO: 24433) which is an opportunistic pathogenic yeast. Both dry and fresh ethanolic extracts showed a comparatively higher zone of inhibition for all the microbes. Aqueous dry and fresh extracts showed zone of inhibition for Staphylococcus aureus and Enterococcus faecalis, where as none of the extracts showed antimicrobial activity against Candida albicans. Results from the above study suggest that the ethanolic extract of Rosa indica petal are an encouraging alternative to some of the antibacterial drugs. This in turn would potentially be used as natural source to treat various multi drug resistant bacterial strains.
植物是多种次生代谢物的宝贵来源,这些代谢物自古以来就被用作药物。使用植物作为药物来源的最无可争议的优点是它们价格低廉,易于获得,副作用很小。本研究对蔷薇花瓣的干、鲜水、乙醇和氯仿提取物进行了比较分析,以进行其植物化学筛选。结果证实在水提液和乙醇提液中几乎存在所有被测的次生代谢物,而氯仿提液中仅存在皂苷。进一步的研究仅用干燥和新鲜的玫瑰花瓣水提取物和乙醇提取物对革兰氏阴性细菌的抑菌活性,包括大肠杆菌(ATCC NO: 25922)、铜绿假单胞菌(ATCC NO: 27853)和革兰氏阳性细菌,包括金黄色葡萄球菌(ATCC NO: 43300)、粪肠球菌(ATCC NO: 29212)和白色念珠菌(ATCC NO: 24433),这是一种机会致病性酵母。干燥和新鲜乙醇提取物对所有微生物均有较高的抑制区。干燥水提液和新鲜水提液对金黄色葡萄球菌和粪肠球菌均有抑菌作用,对白色念珠菌均无抑菌作用。上述研究结果表明,玫瑰花瓣乙醇提取物是一些抗菌药物的令人鼓舞的替代品。这反过来又可能被用作治疗各种多重耐药细菌菌株的天然来源。
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引用次数: 0
Evaluation of Antioxidant Properties of Microgreen Masala Mix and Assessment of Organoleptic Properties of Microgreen Masala Mix Incorporated Products 微绿马沙拉混合物抗氧化性能评价及微绿马沙拉混合物合并产品感官性能评价
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.29685
Sneha K. S., Anees Fathima Thabassum Z, M. Reddy, Shivakumara C. S., S. A
The study aimed to develop masala mix using microgreens, to assess the organoleptic properties of products prepared by incorporating Microgreen Masala Mix (MMM) and compare the antioxidant properties of the most acceptable variation of MMM with Standard Masala Mix (SMM). Four varieties of microgreens - Spinach, Fenugreek, Coriander and Amaranthus were cultivated, harvested, dehydrated and powdered separately. A microgreen mix (MM) was prepared by mixing 5 g each of the dehydrated powder. SMM was prepared using different spices.MMM was prepared by replacing the SMM with MM at 10, 15 and 20% (i.e Variation- 1,2 and 3) respectively. Masala rice and Masala potato fry were prepared by incorporating SMM and MMM. Sensory attributes of the developed products were evaluated by 15 semi-trained panellists using 9 point hedonic scale. Masala rice-Standard and variation 1 had a higher and similar mean score of 8.4±0.63 and 8.4±0.82 respectively. A similar trend was noticed for masala potato fry, where standard and variation 1 had a mean score of 8.13±0.74 and 7.9±1.33 respectively indicating a high overall acceptability. Hence, the antioxidant properties of MMM (variation 1) were analysed and compared with SMM. MMM (variation 1) had high total phenolic content (55.7 ?g of gallic acid equivalent/ml) and essentially similar flavonoid content (13.45 ? Quercetin/ml). The free radical scavenging activity IC50 value of variation 1 was higher (99.0 ?g/ml) than the standard. Microgreens are rich source of antioxidants hence incorporating microgreens in regular recipes along with other spices and condiments will prove useful to maintain health.
本研究的目的是研制用微绿色masala混合物,评估加入微绿色masala混合物(MMM)制备的产品的感官特性,并比较最可接受的MMM变体与标准masala混合物(SMM)的抗氧化性能。四种微型蔬菜——菠菜、胡芦巴、香菜和苋菜——分别种植、收获、脱水和粉化。将各5 g的脱水粉末混合制成微绿混合物。采用不同的香料制备SMM。用分别为10、15和20%(即变异- 1、2和3)的MM代替SMM制备MMM。以SMM和MMM为原料制备了马沙拉米饭和马沙拉土豆炒饭。开发产品的感官属性由15名半训练小组成员使用9分享乐量表进行评估。标准稻和变异1的平均评分较高,分别为8.4±0.63和8.4±0.82。马萨拉薯片也有类似的趋势,标准和变异1的平均得分分别为8.13±0.74和7.9±1.33,表明总体可接受性较高。因此,对变异1的MMM进行了抗氧化性能分析,并与SMM进行了比较。MMM(变异1)总酚含量高(55.7 μ g没食子酸当量/ml),类黄酮含量基本相似(13.45 μ g /ml)。槲皮素/毫升)。变异1的自由基清除活性IC50值(99.0 ?g/ml)高于标准。微蔬菜是抗氧化剂的丰富来源,因此在日常食谱中加入微蔬菜以及其他香料和调味品将被证明对保持健康有益。
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引用次数: 0
Association of Vitamin B12 Status with Biochemical Parameters among the Adult Population (30 - 50 Years) of Vallabh Vidyanagar, Anand, Gujarat 古吉拉特邦阿南德Vallabh Vidyanagar地区30 - 50岁成年人群维生素B12水平与生化指标的关系
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.29068
Revati Shah, Vinayak Patel, N. Dave
Vitamin B12 deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B12 deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B12 deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B12 deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B12 and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B12 deficiency. The subjects were screened for their vitamin B12 status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ? 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ? 0.05) relationship was observed between serum vitamin B12 and iron levels (r = 0.127, P ? 0.05) of the subjects. In conclusion, vitamin B12 status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration
维生素B12缺乏症在素食人群中是非常普遍的,并且由于各种血液学和神经精神疾病而导致高同型半胱氨酸血症。维生素B12缺乏症是一种由吸收不良和摄入不足引起的全球性流行病。维生素B12缺乏对血液和神经系统的影响最大。甲基丙二酸(MMA)和/或总同型半胱氨酸水平升高是维生素B12缺乏的敏感迹象,与临床问题有关。血液学参数,如红细胞计数,血红蛋白浓度或红细胞压积,平均细胞体积(MCV),血液值,如血浆B12和代谢物MMA只是几个例子。从古吉拉特邦阿南德的Vallabh Vidyanagar挑选了398名年龄在30-50岁之间的受试者。42%的研究对象缺乏维生素B12。筛查受试者的维生素B12状态和几个生化参数,如同型半胱氨酸、铁、血红蛋白、总红细胞、PCV、MCV、MCH、MCHC和RDW。发现受试者的总红细胞、MCV、MCH、MCHC水平和同型半胱氨酸浓度显著(P ?0.05)与受试者的维生素B12状况有关。(P ?血清维生素B12与铁水平呈正相关(r = 0.127, P ?0.05)。综上所述,维生素B12水平与总红细胞、MCV、MCH、MCHC水平和同型半胱氨酸浓度显著相关
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引用次数: 0
Application of Probiotics, Prebiotics and Synbiotics in Maintaining Gut Health 益生菌、益生元及合成菌在维持肠道健康中的应用
Pub Date : 2022-07-13 DOI: 10.21048/ijnd.2022.59.3.29516
.. Upasana
The health benefits proclaimed by probiotics, prebiotics, and synbiotics have been the subject of extensive research for the last few decades. Researchers focused on searching the role of probiotics, prebiotics, and synbiotics that help in maintaining gastrointestinal tract health. Many studies stated that probiotics, prebiotics, and synbiotics supplementation is beneficial in maintaining optimal microflora in the gut that ultimately helps in the prevention of numerous diseases associated with nutritional health. This review article portrays various roles played by probiotics, prebiotics, and synbiotics in maintaining the beneficial microbiota of the human gut.
在过去的几十年里,益生菌、益生元和合成菌所宣称的健康益处一直是广泛研究的主题。研究人员专注于寻找益生菌、益生元和合成菌在维持胃肠道健康方面的作用。许多研究表明,补充益生菌、益生元和合成菌有利于维持肠道内最佳的微生物群,最终有助于预防与营养健康相关的许多疾病。本文综述了益生菌、益生元和合成菌在维持人体肠道有益菌群中的各种作用。
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The Indian journal of nutrition and dietetics
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