The anti-ulcer effect of extracts of Cordia dichotoma Forst.f. fruits (300mg/kg body weight) was studied in albino rats of Wistar strain using three different models i.e. pyloric ligation, aspirin and indomethacin induced ulcers. The extractions of C.dichotoma Forst.f. fruits were carried out using ethanol. This extract was fractionated using petroleum ether, solvent ether, ethyl acetate, butanol and butanone in succession. Gastric mucosal injury was produced in rats by pyloric ligation, aspirin and indomethacin induced models. Extracts of petroleum ether, solvent ether, ethyl acetate, butanol and butanone were administered in a dose of 300 mg/kg body weight. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicates that, extracts of ethyl acetate, butanol and butanone significantly (p< 0.001) decrease the volume of gastric secretion, free acidity, total acidity and ulcer index with respect to control. The results suggest that the extracts of Cordia dichotoma Forst.f. fruits possess significant anti-ulcer activity.
{"title":"Anti-ulcer effect of Cordia dichotoma Forst .f. fruits against gastric ulcers in rats.","authors":"I. Kuppast, P. Nayak, K. C. Prakash, K. Kumar","doi":"10.5580/14b9","DOIUrl":"https://doi.org/10.5580/14b9","url":null,"abstract":"The anti-ulcer effect of extracts of Cordia dichotoma Forst.f. fruits (300mg/kg body weight) was studied in albino rats of Wistar strain using three different models i.e. pyloric ligation, aspirin and indomethacin induced ulcers. The extractions of C.dichotoma Forst.f. fruits were carried out using ethanol. This extract was fractionated using petroleum ether, solvent ether, ethyl acetate, butanol and butanone in succession. Gastric mucosal injury was produced in rats by pyloric ligation, aspirin and indomethacin induced models. Extracts of petroleum ether, solvent ether, ethyl acetate, butanol and butanone were administered in a dose of 300 mg/kg body weight. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicates that, extracts of ethyl acetate, butanol and butanone significantly (p< 0.001) decrease the volume of gastric secretion, free acidity, total acidity and ulcer index with respect to control. The results suggest that the extracts of Cordia dichotoma Forst.f. fruits possess significant anti-ulcer activity.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81389890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To study the effect of the methanolic extract of Urena lobata Linn. on invitro immunostimulant activity.Method: Different concentrations (5-100μg/ml) of methanolic extract ofUrena lobata was subjected for its immunomodulatory activity using human blood by phagocytosis.Result: This study revealed that the methanolic extract of Urena lobata Linn. has phagocytosis and intracellular killing potency of human neutrophils at different concentration.Conclusion: Urena lobata Linn posses’ immunomodulatory property.
{"title":"Immunomodulatory activity of the methanolic extract of Urena lobata Linn.","authors":"Mathappan Rinku, V. Prasanth, G. Parthasarathy","doi":"10.5580/ba4","DOIUrl":"https://doi.org/10.5580/ba4","url":null,"abstract":"Purpose: To study the effect of the methanolic extract of Urena lobata Linn. on invitro immunostimulant activity.Method: Different concentrations (5-100μg/ml) of methanolic extract ofUrena lobata was subjected for its immunomodulatory activity using human blood by phagocytosis.Result: This study revealed that the methanolic extract of Urena lobata Linn. has phagocytosis and intracellular killing potency of human neutrophils at different concentration.Conclusion: Urena lobata Linn posses’ immunomodulatory property.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84107621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study was designed to verify the antidyslipidemic effect of Aegle marmelos Linn. unripe fruit aqueous extract (AMUFAEt) against isoproterenol (IPL) induced cardiac stressed rats. Rats were divided into four groups (of six each): group I of healthy controls, group II of AMUFAEt treated (150 mg/kg body weight, for 45 days), group III of IPL treated rats (85 mg/kg body weight, once a day for 2 days) and group IV of AMUFAEt treated (150 mg/kg body weight, for 45days) and then IPL administered. The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and phospholipids (PL) was significantly increased, while the levels of high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) decreased in serum of IPL treated rats. In AMUFAEt pretreated rats the dyslipidaemic effects of IPL were compensated to near normal levels. Blood glucose, protein levels were not significantly altered. The study shows that the extract has significant antidyslipidaemic effect.
{"title":"Antidyslipidaemic effect of Aegle marmelos Linn. fruit on Isoproterenol induced myocardial injury in rats","authors":"G. S. Krushna, M. Kareem, K. Devi","doi":"10.5580/1138","DOIUrl":"https://doi.org/10.5580/1138","url":null,"abstract":"The present study was designed to verify the antidyslipidemic effect of Aegle marmelos Linn. unripe fruit aqueous extract (AMUFAEt) against isoproterenol (IPL) induced cardiac stressed rats. Rats were divided into four groups (of six each): group I of healthy controls, group II of AMUFAEt treated (150 mg/kg body weight, for 45 days), group III of IPL treated rats (85 mg/kg body weight, once a day for 2 days) and group IV of AMUFAEt treated (150 mg/kg body weight, for 45days) and then IPL administered. The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and phospholipids (PL) was significantly increased, while the levels of high density lipoprotein cholesterol (HDL-C) and triglycerides (TG) decreased in serum of IPL treated rats. In AMUFAEt pretreated rats the dyslipidaemic effects of IPL were compensated to near normal levels. Blood glucose, protein levels were not significantly altered. The study shows that the extract has significant antidyslipidaemic effect.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"49 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91554009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prasanth Vv, G. Parthasarathy, A. Puratchikody, A. K. Balaraman, B. Vinod, N. S. Chandrasheker, S. Mathew
Purpose: The objective of the study was to select a suitable polymer for immobilization of pancreatic porcine lipase by entrapment method and to evaluate the kinetic properties of immobilized enzyme with free enzyme. Method:. Enzyme was immobilized by entrapment method using calcium alginate and barium alginate polymers. Lipase activity was determined by titrimetric assay procedure. Km and Vmax were determined with Michaelis Menton Equation. Result: The present work demonstrated that calcium alginate beads loaded with enzyme is more stable at high temperature and has excellent Vmax and Km in comparison with barium alginate beads.. Compare to immobilized enzyme free enzyme could not withstand high temperature. Conclusion: Sodium alginate polymer is an excellent carrier for entrapment of pancreatic porcine lipase.
{"title":"Immobilization of pancreatic porcine lipase in calcium and barium alginate comparative studies of their kinetic properties and screening the polymer for suitability","authors":"Prasanth Vv, G. Parthasarathy, A. Puratchikody, A. K. Balaraman, B. Vinod, N. S. Chandrasheker, S. Mathew","doi":"10.5580/1b32","DOIUrl":"https://doi.org/10.5580/1b32","url":null,"abstract":"Purpose: The objective of the study was to select a suitable polymer for immobilization of pancreatic porcine lipase by entrapment method and to evaluate the kinetic properties of immobilized enzyme with free enzyme. Method:. Enzyme was immobilized by entrapment method using calcium alginate and barium alginate polymers. Lipase activity was determined by titrimetric assay procedure. Km and Vmax were determined with Michaelis Menton Equation. Result: The present work demonstrated that calcium alginate beads loaded with enzyme is more stable at high temperature and has excellent Vmax and Km in comparison with barium alginate beads.. Compare to immobilized enzyme free enzyme could not withstand high temperature. Conclusion: Sodium alginate polymer is an excellent carrier for entrapment of pancreatic porcine lipase.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"135 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78190522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Using carrageenan-induced paw inflammation model in rats, the anti-inflammatory effects of 4-acetyl – 1 phenyl 1-3 methyl 1 pyrazolone (HAP) were investigated and compared with those of standard anti-inflammatory agents viz indomethacin, HTFP (4triflouroacetyl-1 phenyl-3 methyl pyrazolone) and hydrocortisone. Rats were intraperitoneally administered different doses of HAP, HTFP, indomethacin and hydrocortisone and one hour thereafter, inflammation was induced by injecting carrageenan into the left foot. The right foot received saline. Five rats received carrageenan and saline only. Both the left and right feet were measured hourly for inflammatory response for four (4) hours. HAP, HTFP reduced the inflammatory response by 80% whereas hydrocortisone and indomethacin reduced the inflammatory response by 70% and 84% respectively. These results suggest that HAP, a new pyrazolon derivative may possess anti-inflammatory activity comparable to those of standard anti-inflammatory agents.
{"title":"Antinflammatory Activity Of A New Pyrazolon Drug","authors":"O. Georgewill, U. Georgewill, R. Nwankwoala","doi":"10.5580/12ad","DOIUrl":"https://doi.org/10.5580/12ad","url":null,"abstract":"Using carrageenan-induced paw inflammation model in rats, the anti-inflammatory effects of 4-acetyl – 1 phenyl 1-3 methyl 1 pyrazolone (HAP) were investigated and compared with those of standard anti-inflammatory agents viz indomethacin, HTFP (4triflouroacetyl-1 phenyl-3 methyl pyrazolone) and hydrocortisone. Rats were intraperitoneally administered different doses of HAP, HTFP, indomethacin and hydrocortisone and one hour thereafter, inflammation was induced by injecting carrageenan into the left foot. The right foot received saline. Five rats received carrageenan and saline only. Both the left and right feet were measured hourly for inflammatory response for four (4) hours. HAP, HTFP reduced the inflammatory response by 80% whereas hydrocortisone and indomethacin reduced the inflammatory response by 70% and 84% respectively. These results suggest that HAP, a new pyrazolon derivative may possess anti-inflammatory activity comparable to those of standard anti-inflammatory agents.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73285846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
For years, learning and memory were considered to be electrical activities processed in the nervous system. The memory appeared to be stored in certain circuits in the brain, such as the limbic system. The knowledge embedded with a transactive memory system helps groups apply prior learning to new tasks and develop an abstract understanding of a problem domain, leading to sustained performance.The memory and learning process have their own chemical bases. Many chemical factors including neurotransmitters influences learning and memory through actions on different brain regions. This review is prepared with the view that an increased understanding of mechanism associated with memory and learning will opened up the possibility to explore drugs acting on cognitive functions. A central claim of this wonderful assemblage of articles is that memory is a hyphenated phenomenon, a material-semiotic one. It is a conceptual site where phenomenology meets ontology meets materiality.
{"title":"Pharmacology Of Learning And Memory","authors":"M. Phale, D. Korgaonkar","doi":"10.5580/2319","DOIUrl":"https://doi.org/10.5580/2319","url":null,"abstract":"For years, learning and memory were considered to be electrical activities processed in the nervous system. The memory appeared to be stored in certain circuits in the brain, such as the limbic system. The knowledge embedded with a transactive memory system helps groups apply prior learning to new tasks and develop an abstract understanding of a problem domain, leading to sustained performance.The memory and learning process have their own chemical bases. Many chemical factors including neurotransmitters influences learning and memory through actions on different brain regions. This review is prepared with the view that an increased understanding of mechanism associated with memory and learning will opened up the possibility to explore drugs acting on cognitive functions. A central claim of this wonderful assemblage of articles is that memory is a hyphenated phenomenon, a material-semiotic one. It is a conceptual site where phenomenology meets ontology meets materiality.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"185 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81596753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study was aimed at comparing the pharmacodynamics of simvastatin (S) with atorvastatin in hyperlipidemic rats. The standard cholesterol diet was used to induce hyperlipidemia in Wister rats. The blood samples were collected from simvastatin and atorvastatin treated rats and analyzed for pharmacodynamics (lipid profiles) of using reported methods. Simvastatin produced a more significant change in lipid profiles than atorvastatin.
{"title":"A Comparative Antihyperlipidemic Activity Of Atorvastatin With Simvastatin In Rats","authors":"G. Rajyalakshmi, A. N. Reddy, V. V. Rajesham","doi":"10.5580/203b","DOIUrl":"https://doi.org/10.5580/203b","url":null,"abstract":"The present study was aimed at comparing the pharmacodynamics of simvastatin (S) with atorvastatin in hyperlipidemic rats. The standard cholesterol diet was used to induce hyperlipidemia in Wister rats. The blood samples were collected from simvastatin and atorvastatin treated rats and analyzed for pharmacodynamics (lipid profiles) of using reported methods. Simvastatin produced a more significant change in lipid profiles than atorvastatin.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"83 2 Suppl 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88687958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the study is to study the anti-ulcer activity of the ethanolic extract of theleaves of Psidium guajava on experimental animal models. Four groups of albino rats weighing 130-180grams were taken for the study (n=6).Group I : control (3%gum acacia 5ml/kg/day orally for 7days).Group II :Experimental control(Aspirin 400mg/kg orally as single dose on 7th day).Group III :Test (Psidium guajava extract 200mg/kg/day orally for 7days and Aspirin 400mg/kg orally on 7th day) and Group IV:Standard(Ranitidine150mg/kg orally for 7days and Aspirin 400mg/kg orally on 7th day).The stomachs of the sacrificed rats were removed and (1)volume of gastric juice (2)ulcer index (3)pepsin activity(4)free acidity(5)total acidity (6)gastric mucus secretion were studied. The ulcer index, pepsin activity, free and total acidity and volume of gastric juice in group III and IV showed significant decrease in comparison to group II whereas there is increase in gastric mucus secretion (p<.01).
{"title":"A study of the anti-ulcer activity of the ethanolic extract of the leaves of Psidium guajava on experimental animal models","authors":"Swarnamoni Das, S. Dutta, S. Deka","doi":"10.5580/5b","DOIUrl":"https://doi.org/10.5580/5b","url":null,"abstract":"The aim of the study is to study the anti-ulcer activity of the ethanolic extract of theleaves of Psidium guajava on experimental animal models. Four groups of albino rats weighing 130-180grams were taken for the study (n=6).Group I : control (3%gum acacia 5ml/kg/day orally for 7days).Group II :Experimental control(Aspirin 400mg/kg orally as single dose on 7th day).Group III :Test (Psidium guajava extract 200mg/kg/day orally for 7days and Aspirin 400mg/kg orally on 7th day) and Group IV:Standard(Ranitidine150mg/kg orally for 7days and Aspirin 400mg/kg orally on 7th day).The stomachs of the sacrificed rats were removed and (1)volume of gastric juice (2)ulcer index (3)pepsin activity(4)free acidity(5)total acidity (6)gastric mucus secretion were studied. The ulcer index, pepsin activity, free and total acidity and volume of gastric juice in group III and IV showed significant decrease in comparison to group II whereas there is increase in gastric mucus secretion (p<.01).","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89805294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes is a progressive disease with acute and chronic morbidities and high mortality. At present there are 171 million diabetic patients in the world with India accounting for 31.7 million. Prevalence in India is expected to increase to 79.4 million by the year 2030[1]. Approximately 85 -90% of these people have type 2 diabetes mellitus. The illness is best managed by combining patient education and long-term medical care to prevent or to reduce the risk of long-term complications. Diabetes is associated with serious health consequences. It has been the leading cause of coronary heart disease (CHD), stroke and chronic renal failure, hypertension, atherosclerosis, endothelial dysfunction. Management of diabetes is intricate and requires many issues be addressed beyond glycemic control alone. According to American Diabetic Associtaion (2002), the cost related to diabetes for hospitalization and complications was $132 billion [3] and formed 34% of the medical budget. A large body of evidence exists that supports a range of interventions to improve diabetes outcomes. The studies like UKPDS [4-6], DCCT [7, 8] and Kumamoto [9] have shown a significant decrease in cost and complications with an intensive glycemic and blood pressure control.Diabetes is a chronic disease treated for long with goal of ‘secondary prevention’ but failed to provide complete prevention of complications. The rising prevalence of the disease and cost of treatment will probably offset its benefits to the community. A shift in paradigm from secondary prevention to primary prevention of diabetes is the need of the hour but has been neglected or as has been underachieved in routine clinical practice.
{"title":"Diabetes :A Paradigm and its Prevention","authors":"A. Dash, Tejaswi Kumar, N. Agarwal","doi":"10.5580/1d3c","DOIUrl":"https://doi.org/10.5580/1d3c","url":null,"abstract":"Diabetes is a progressive disease with acute and chronic morbidities and high mortality. At present there are 171 million diabetic patients in the world with India accounting for 31.7 million. Prevalence in India is expected to increase to 79.4 million by the year 2030[1]. Approximately 85 -90% of these people have type 2 diabetes mellitus. The illness is best managed by combining patient education and long-term medical care to prevent or to reduce the risk of long-term complications. Diabetes is associated with serious health consequences. It has been the leading cause of coronary heart disease (CHD), stroke and chronic renal failure, hypertension, atherosclerosis, endothelial dysfunction. Management of diabetes is intricate and requires many issues be addressed beyond glycemic control alone. According to American Diabetic Associtaion (2002), the cost related to diabetes for hospitalization and complications was $132 billion [3] and formed 34% of the medical budget. A large body of evidence exists that supports a range of interventions to improve diabetes outcomes. The studies like UKPDS [4-6], DCCT [7, 8] and Kumamoto [9] have shown a significant decrease in cost and complications with an intensive glycemic and blood pressure control.Diabetes is a chronic disease treated for long with goal of ‘secondary prevention’ but failed to provide complete prevention of complications. The rising prevalence of the disease and cost of treatment will probably offset its benefits to the community. A shift in paradigm from secondary prevention to primary prevention of diabetes is the need of the hour but has been neglected or as has been underachieved in routine clinical practice.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"83 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83620056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Beg, Y. Siddique, G. Ara, J. Gupta, Mohammad Afzal
This experiment was conducted in order to assess the antigenotoxicity potential of Epigallocatechin-3-gallate (EGCG), a catechin, against genotoxicity induced by anticancer drugs, Methyl methanesulphonate (MMS) and cyclophosphamide (CP), in the form of chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs). These drugs were used at 60 M and 0.16 g/ml respectively along with EGCG at 10, 20, and 30 M in cultured human lymphocyte chromosomes. EGCG significantly reduced the genotoxic damage induced by the two drugs both in the presence and absence of metabolic activation system (S9 mix), although with greater effectiveness in the presence of metabolic activation.
{"title":"Protective action of EGCG against anticancer drugs MMS and CP","authors":"T. Beg, Y. Siddique, G. Ara, J. Gupta, Mohammad Afzal","doi":"10.5580/19b4","DOIUrl":"https://doi.org/10.5580/19b4","url":null,"abstract":"This experiment was conducted in order to assess the antigenotoxicity potential of Epigallocatechin-3-gallate (EGCG), a catechin, against genotoxicity induced by anticancer drugs, Methyl methanesulphonate (MMS) and cyclophosphamide (CP), in the form of chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs). These drugs were used at 60 M and 0.16 g/ml respectively along with EGCG at 10, 20, and 30 M in cultured human lymphocyte chromosomes. EGCG significantly reduced the genotoxic damage induced by the two drugs both in the presence and absence of metabolic activation system (S9 mix), although with greater effectiveness in the presence of metabolic activation.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88642013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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