Pub Date : 2020-12-01DOI: 10.22271/tpi.2020.v9.i12sa.5421
D. Kalaiarasi, N. Palanichamy, S. Praveena
Company's financial position over the years is useful for decision making and which helps to alter the company in profit direction. The present study analysed the financial performance of Mango pulp processing unit located at Tamil Nadu. The company's financial performance has been thoroughly examined for a period of five years from 2014-2019. The data was collected from the secondary sources and published reports of the case firm.From the results, it is evident that the case firm must maintain appropriate bank balance, cash at hand, and short-term investment in current assets in order to increase the good liquidity position. Lower total asset turnover ratio of the case firm indicates too much capital is tied up in assets and that asset is not being used efficiently in generating revenue. It is suggested that the case firm has to increase its profitability by managing its operating cost.
{"title":"Financial performance analysis of mango pulp processing unit: A case analysis","authors":"D. Kalaiarasi, N. Palanichamy, S. Praveena","doi":"10.22271/tpi.2020.v9.i12sa.5421","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i12sa.5421","url":null,"abstract":"Company's financial position over the years is useful for decision making and which helps to alter the company in profit direction. The present study analysed the financial performance of Mango pulp processing unit located at Tamil Nadu. The company's financial performance has been thoroughly examined for a period of five years from 2014-2019. The data was collected from the secondary sources and published reports of the case firm.From the results, it is evident that the case firm must maintain appropriate bank balance, cash at hand, and short-term investment in current assets in order to increase the good liquidity position. Lower total asset turnover ratio of the case firm indicates too much capital is tied up in assets and that asset is not being used efficiently in generating revenue. It is suggested that the case firm has to increase its profitability by managing its operating cost.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"276 1","pages":"41-44"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77104649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-01DOI: 10.22271/TPI.2020.V9.I10E.5251
Meenakshi, Vivek Sharma
Human Milk has been considered sterile and It helps to create the right environment for gut development and maturation of newborns babies. Current research is focusing on bacterial diversity and the influence of the maternal environment as well as the mode of delivery on human milk microbiota, the pathway of bacterial transfer to milk ducts, possible benefits of specific bacterial strains to new born baby. The presence of immunomodulatory factors in human milk like exosomes and microRNAs have been found. Breast milk contains many complex proteins, lipids and carbohydrates, the concentration of which alter dramatically over a single feed as well as over lactation, to reflect the infants need. Probiotics as a substance and organisms which when administered in proper amount confer health benefits for newborns babies. However, their potential benefits remain now days unexplored, as long as they are included in genera with pathogenic representatives.
{"title":"The human milk microbiota-origin, probiotics properties and its benefits for Newborns babies","authors":"Meenakshi, Vivek Sharma","doi":"10.22271/TPI.2020.V9.I10E.5251","DOIUrl":"https://doi.org/10.22271/TPI.2020.V9.I10E.5251","url":null,"abstract":"Human Milk has been considered sterile and It helps to create the right environment for gut development and maturation of newborns babies. Current research is focusing on bacterial diversity and the influence of the maternal environment as well as the mode of delivery on human milk microbiota, the pathway of bacterial transfer to milk ducts, possible benefits of specific bacterial strains to new born baby. The presence of immunomodulatory factors in human milk like exosomes and microRNAs have been found. Breast milk contains many complex proteins, lipids and carbohydrates, the concentration of which alter dramatically over a single feed as well as over lactation, to reflect the infants need. Probiotics as a substance and organisms which when administered in proper amount confer health benefits for newborns babies. However, their potential benefits remain now days unexplored, as long as they are included in genera with pathogenic representatives.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"32 1","pages":"340-342"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83470938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-01DOI: 10.22271/tpi.2020.v9.i10e.5258
R. Raj, K. Lata, V. Raj, Mukul Kumar
According to the state of food security and nutrition, Hunger has increased in many countries in which the economy has slowed down, mostly in middle-income countries. If nothing changes, the immense challenge of achieving the Zero Hunger Target by 2030. The causes of food scarcity might include factors such as unavailability of food due to less production of particular crops/vegetables (due to attack of pests/microbes), it becomes harder to fulfill the basic needs of life especially for poor. Therefore, we need to primarily focus on understanding the interaction between plants and microbes at the molecular level and underlying mechanisms of plant disease and which will help out to solve the global needs of food and resources. Plants have a natural defense mechanism/immune system to react to infections which subdivides into two parts. The first part identifies and reacts to molecules common to different classes of microbes, including non-pathogen. The function of the second part is to react to pathogens virulence factors, either directly or by affecting the host targets. We can also see the intricacies or reciprocation between plants and pathogen attackers. A vast and deep comprehension of plant defense mechanisms will defiantly solve the issue, like food scarcity.
{"title":"The defense mechanism of plant","authors":"R. Raj, K. Lata, V. Raj, Mukul Kumar","doi":"10.22271/tpi.2020.v9.i10e.5258","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i10e.5258","url":null,"abstract":"According to the state of food security and nutrition, Hunger has increased in many countries in which the economy has slowed down, mostly in middle-income countries. If nothing changes, the immense challenge of achieving the Zero Hunger Target by 2030. The causes of food scarcity might include factors such as unavailability of food due to less production of particular crops/vegetables (due to attack of pests/microbes), it becomes harder to fulfill the basic needs of life especially for poor. Therefore, we need to primarily focus on understanding the interaction between plants and microbes at the molecular level and underlying mechanisms of plant disease and which will help out to solve the global needs of food and resources. Plants have a natural defense mechanism/immune system to react to infections which subdivides into two parts. The first part identifies and reacts to molecules common to different classes of microbes, including non-pathogen. The function of the second part is to react to pathogens virulence factors, either directly or by affecting the host targets. We can also see the intricacies or reciprocation between plants and pathogen attackers. A vast and deep comprehension of plant defense mechanisms will defiantly solve the issue, like food scarcity.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"32 1","pages":"355-360"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85897437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-01DOI: 10.22271/TPI.2020.V9.I10D.5243
Ankit Kamboj, Jagdish Kaur, Paramjit Singh, H. Kaur
Cerebrospinal fluid (CSF) analysis offers the most innocuous analytical tool for assessing the cellular and biochemical environment of CNS and hence aids in studying neurometabolomic conditions. The aim of this study was to assess the effect of blood contamination of CSF on the levels of selected biogenic amines and vitamins. CSF samples were spiked with increasing volumes of whole fresh blood (2.5%, 5%, 10% and 20%) under conditions: (a) spiking of pooled CSF samples followed by freezing to cause red blood cell (RBC) lysis; (b) spiking of pooled CSF samples followed by centrifugation to remove RBCs. CSF concentrations of two biogenic amines Homovanillic acid (HVA) and 5-hydroxyindoleaceticacid (5-HIAA); and three vitamins Pyridoxal 5’-phosphate (PLP),5-methyltetrahydrofolate (MTHF) and Thiamine were analysed by HPLC coupled with electrochemical detection. HVA and 5-HIAA illustrated lower values when RBC lysis was caused. However, PLP, 5-MTHF, and thiamine depicted higher concentrations on RBC lysis in contrast to RBC removal. CSF metabolomic investigations involving biogenic amines and vitamins as biomarkers is possible even when remarkable RBC CSF contamination occurs provided that CSF is centrifuged for the removal of RBC prior to freezing.
{"title":"Blood contamination in cerebrospinal fluid and its effect on biogenic amines and vitamins","authors":"Ankit Kamboj, Jagdish Kaur, Paramjit Singh, H. Kaur","doi":"10.22271/TPI.2020.V9.I10D.5243","DOIUrl":"https://doi.org/10.22271/TPI.2020.V9.I10D.5243","url":null,"abstract":"Cerebrospinal fluid (CSF) analysis offers the most innocuous analytical tool for assessing the cellular and biochemical environment of CNS and hence aids in studying neurometabolomic conditions. The aim of this study was to assess the effect of blood contamination of CSF on the levels of selected biogenic amines and vitamins. CSF samples were spiked with increasing volumes of whole fresh blood (2.5%, 5%, 10% and 20%) under conditions: (a) spiking of pooled CSF samples followed by freezing to cause red blood cell (RBC) lysis; (b) spiking of pooled CSF samples followed by centrifugation to remove RBCs. CSF concentrations of two biogenic amines Homovanillic acid (HVA) and 5-hydroxyindoleaceticacid (5-HIAA); and three vitamins Pyridoxal 5’-phosphate (PLP),5-methyltetrahydrofolate (MTHF) and Thiamine were analysed by HPLC coupled with electrochemical detection. HVA and 5-HIAA illustrated lower values when RBC lysis was caused. However, PLP, 5-MTHF, and thiamine depicted higher concentrations on RBC lysis in contrast to RBC removal. CSF metabolomic investigations involving biogenic amines and vitamins as biomarkers is possible even when remarkable RBC CSF contamination occurs provided that CSF is centrifuged for the removal of RBC prior to freezing.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"28 1","pages":"294-298"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87476530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.22271/tpi.2020.v9.i9d.5125
M. Srivani, Y. N. Reddy, K. Subramanyam, M. Lakshman, K. Kavitha, R. Pushpa
A study was carried out to investigate the epidemiology, molecular characterization and antibiotic resistance of Necrotoxigenic E. coli (NTEC) isolated from diarrhoeic calves in Andhra Pradesh (AP) and Telangana States (TS). A total of 129 faecal samples from diarrhoeic buffalo calves of 1 to 90 days were collected from various districts in AP and TS, of which 60 E.coli were isolated. The cnf2 gene was detected by PCR and In vitro antibiotic susceptibility was tested by disk diffusion methods. The prevalence of E.coli associated diarrhea in calves was 46.51% of which 5.0% was due to NTEC based on the presence of cnf2 gene and none of the E.coli isolates possessed cnf1 gene. The NTEC isolates from diarrhoeic calves showed higher antibiotic resistance to tetracyclin and aztreonam (66.67%) and sensitive to ampicillin, cefotaxime, ceftazidime, amoxycillinclavulinicacid, gentamycin, kanamycin, streptomycin, sulfisoxazole, cotrimoxazole, ciprofloxacin, chloramphenicol and imipenem antibiotics. The present study provides baseline data on epidemiology of E.coli associated diarrhoeia, NTEC prevalence and antimicrobial resistance in calves which will help in formulating prophylactic and preventive measures in this geographic region.
{"title":"Epidemiology, molecular characterization and antimicrobial resistance of Necrotoxigenic Escherichia coli in diarrhoeic calves","authors":"M. Srivani, Y. N. Reddy, K. Subramanyam, M. Lakshman, K. Kavitha, R. Pushpa","doi":"10.22271/tpi.2020.v9.i9d.5125","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i9d.5125","url":null,"abstract":"A study was carried out to investigate the epidemiology, molecular characterization and antibiotic resistance of Necrotoxigenic E. coli (NTEC) isolated from diarrhoeic calves in Andhra Pradesh (AP) and Telangana States (TS). A total of 129 faecal samples from diarrhoeic buffalo calves of 1 to 90 days were collected from various districts in AP and TS, of which 60 E.coli were isolated. The cnf2 gene was detected by PCR and In vitro antibiotic susceptibility was tested by disk diffusion methods. The prevalence of E.coli associated diarrhea in calves was 46.51% of which 5.0% was due to NTEC based on the presence of cnf2 gene and none of the E.coli isolates possessed cnf1 gene. The NTEC isolates from diarrhoeic calves showed higher antibiotic resistance to tetracyclin and aztreonam (66.67%) and sensitive to ampicillin, cefotaxime, ceftazidime, amoxycillinclavulinicacid, gentamycin, kanamycin, streptomycin, sulfisoxazole, cotrimoxazole, ciprofloxacin, chloramphenicol and imipenem antibiotics. The present study provides baseline data on epidemiology of E.coli associated diarrhoeia, NTEC prevalence and antimicrobial resistance in calves which will help in formulating prophylactic and preventive measures in this geographic region.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73413985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22271/tpi.2020.v9.i8a.5033
F. Owusu, E. Amenuke, P. Entsie, G. Yeboah, Rachel Aboagye
One important requirement for patients to believe and adhere to their medication is for them to have enough knowledge about the medications being dispensed to them. This can easily be achieved by effective counselling and motivation by health care professionals. The manner in which drugs are taken by the patient is often influenced by the way drugs are dispensed and the type of information given to the patient during the dispensing process. The aim of this study was to determine patient beliefs and adherence to their prescribed medications in the Bawku Municipality. The survey was carried out by the use of designed questionnaires. Out of the 100 patients interviewed, 62 % were males and 38 % were females. 14 % of the patients were illiterates and 86 % were literates. Side effects of drugs accounted for 84 % of patients skipping one or more of their medications. 67 % of patient missed their medication due to high cost. 51% also missed their medication due to lack of knowledge on their therapy and 83% were those having received inadequate advice by health care professionals. Also, lack of belief of patients in their medication was 65 %. In conclusion, patient’s beliefs and adherence to their medication was rated bad, and this is largely as a result of insufficient counselling to patients by health care professionals, lack of belief in their medications and high cost of prescribed medications.
{"title":"Patients’ belief and adherence to their medication therapy in the Bawku municipality","authors":"F. Owusu, E. Amenuke, P. Entsie, G. Yeboah, Rachel Aboagye","doi":"10.22271/tpi.2020.v9.i8a.5033","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i8a.5033","url":null,"abstract":"One important requirement for patients to believe and adhere to their medication is for them to have enough knowledge about the medications being dispensed to them. This can easily be achieved by effective counselling and motivation by health care professionals. The manner in which drugs are taken by the patient is often influenced by the way drugs are dispensed and the type of information given to the patient during the dispensing process. The aim of this study was to determine patient beliefs and adherence to their prescribed medications in the Bawku Municipality. The survey was carried out by the use of designed questionnaires. Out of the 100 patients interviewed, 62 % were males and 38 % were females. 14 % of the patients were illiterates and 86 % were literates. Side effects of drugs accounted for 84 % of patients skipping one or more of their medications. 67 % of patient missed their medication due to high cost. 51% also missed their medication due to lack of knowledge on their therapy and 83% were those having received inadequate advice by health care professionals. Also, lack of belief of patients in their medication was 65 %. In conclusion, patient’s beliefs and adherence to their medication was rated bad, and this is largely as a result of insufficient counselling to patients by health care professionals, lack of belief in their medications and high cost of prescribed medications.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"111 1","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80616424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22271/tpi.2020.v9.i8sc.5070
Raghavendran Vb, S. Sureshbabu, S Rajasokkappan, Alex Albert, N. Tamilselvan
A Holstein Friesian crossbred cow maintained at Krishi Vigyan Kendra, Trichy was presented with a history of normal appetite, rumination and defecation but unable to stand. On examination, the physiological parameters were in the normal range. The animal had the urge to get up at times even though it was in sternal recumbency. The blood sample was taken to check the serum calcium and phosphorus. The animal was assisted to stand in slings thrice daily. During that time the hot water massage was provided to all the four limbs of the animal. The position on the animal was changed periodically in order to prevent bed sores. After 18 days of prompt treatment the animal stood up with full recovery and given birth to heifer calf after ten days.
{"title":"Successful recovery of holstein friesian crossbred prepartum downer: A case report","authors":"Raghavendran Vb, S. Sureshbabu, S Rajasokkappan, Alex Albert, N. Tamilselvan","doi":"10.22271/tpi.2020.v9.i8sc.5070","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i8sc.5070","url":null,"abstract":"A Holstein Friesian crossbred cow maintained at Krishi Vigyan Kendra, Trichy was presented with a history of normal appetite, rumination and defecation but unable to stand. On examination, the physiological parameters were in the normal range. The animal had the urge to get up at times even though it was in sternal recumbency. The blood sample was taken to check the serum calcium and phosphorus. The animal was assisted to stand in slings thrice daily. During that time the hot water massage was provided to all the four limbs of the animal. The position on the animal was changed periodically in order to prevent bed sores. After 18 days of prompt treatment the animal stood up with full recovery and given birth to heifer calf after ten days.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"33 1","pages":"102-103"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73082967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-01DOI: 10.22271/tpi.2020.v9.i8b.5012
S. Mallesh, J. T. Raju, Vinay Gautam
An experiment has been carried out on various types of cook stoves including traditional cook stoves, sukhad model, udairaj and improved udairaj models, with which the water-boiling test has been performed to find the thermal efficiency, specific fuel consumption and power rating. The results revealed that Udairaj cook stove and traditional cook stove was found to have the highest and lowest thermal efficiency of 23.4% and 15.4% among the cook stoves tested. Udairaj and improved udairaj cook stoves have similar power rating and lowest specific fuel consumption in the range of 0.811 kW to 0.849 kW and 1.232 kg/kWh to 1.225 kg/kWh respectively, whereas traditional cook stove was found to have the lowest power rating of 0.559 Kwh and highest specific fuel consumption of 1.799 kg/Kwh. Finally, both udairaj and improved udairaj cook stoves have a better thermal efficiency, power rating and specific fuel consumption than traditional cook stoves.
{"title":"Performance evaluation of improved cook stoves","authors":"S. Mallesh, J. T. Raju, Vinay Gautam","doi":"10.22271/tpi.2020.v9.i8b.5012","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i8b.5012","url":null,"abstract":"An experiment has been carried out on various types of cook stoves including traditional cook stoves, sukhad model, udairaj and improved udairaj models, with which the water-boiling test has been performed to find the thermal efficiency, specific fuel consumption and power rating. The results revealed that Udairaj cook stove and traditional cook stove was found to have the highest and lowest thermal efficiency of 23.4% and 15.4% among the cook stoves tested. Udairaj and improved udairaj cook stoves have similar power rating and lowest specific fuel consumption in the range of 0.811 kW to 0.849 kW and 1.232 kg/kWh to 1.225 kg/kWh respectively, whereas traditional cook stove was found to have the lowest power rating of 0.559 Kwh and highest specific fuel consumption of 1.799 kg/Kwh. Finally, both udairaj and improved udairaj cook stoves have a better thermal efficiency, power rating and specific fuel consumption than traditional cook stoves.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"51 1","pages":"119-126"},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81205283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.22271/tpi.2020.v9.i6a.4767
Sanjay K Jain, R. Jain
The purpose of this paper is to identify the cause and effect of increased number of warning letters (www.fda.gov) issued by the Food and Drug Administration (FDA) of United States year after year in spite of clarity in the guidance published by the agency. Increased number of warning letters is matter of concern for the drug product / drug substance manufacturer, drug authority and end consumers (patients). Author identified six pharma professionals through their personal contacts and interviewed each of them. Poor quality management systems and lack of management oversight were found to be the key reasons for issuance of warning letters. Issuance of warning letters had adverse financial impact on business, delay in approvals thus loss of business opportunity and negative image of the organization among regulators, customers. Quality culture in the organization plays an important role to ensure regulatory compliance and building up the right quality culture in the organization is vital. Involvement of top management and participation in the management review meetings is essential for monitoring the compliance level in the organization.
{"title":"Avoiding warning letters in pharmaceutical industry: A qualitative study in the Indian context","authors":"Sanjay K Jain, R. Jain","doi":"10.22271/tpi.2020.v9.i6a.4767","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i6a.4767","url":null,"abstract":"The purpose of this paper is to identify the cause and effect of increased number of warning letters (www.fda.gov) issued by the Food and Drug Administration (FDA) of United States year after year in spite of clarity in the guidance published by the agency. Increased number of warning letters is matter of concern for the drug product / drug substance manufacturer, drug authority and end consumers (patients). Author identified six pharma professionals through their personal contacts and interviewed each of them. Poor quality management systems and lack of management oversight were found to be the key reasons for issuance of warning letters. Issuance of warning letters had adverse financial impact on business, delay in approvals thus loss of business opportunity and negative image of the organization among regulators, customers. Quality culture in the organization plays an important role to ensure regulatory compliance and building up the right quality culture in the organization is vital. Involvement of top management and participation in the management review meetings is essential for monitoring the compliance level in the organization.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"47 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81428287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.22271/tpi.2020.v9.i7g.4973
B. Mohan, H. Saxena, S. Parihar, A. Kakkar
This is a first-time study on Gas Chromatography-Mass Spectrometry (GC-MS) determination of phytoconstituents from ethanolic and aqua-ethanolic root extracts of Uraria picta. It is a commercially importance species which is utilized in Dashmoolarishta, an established ayurvedic drug of ISM. GC-MS determined two major phytoconstituents in ethanolic extract as N-Capric acid Isopropyl Ester (RT- 21.397, 60.98%), 9-Octadecenoic acid (Z) -, Hexyl Ester (RT- 23.298, 39.02%) and three compounds in aqua-ethanolic extract namely Propanoic acid, 2- Hydroxy-, Pentyl Ester (RT- 11.697, 81.64%), α - D-Mannofuranoside, 1-Nonyl - (RT- 20.28, 7.87%) and 2-Bromopropionic acid, Penta decyl ester (RT- 21.486, 6.77%). Four phytocompounds investigated from roots in the present study have commercial significance.
{"title":"Gas chromatography-mass spectrometry (GC-MS) determination of phytoconstituents from ethanolic and aqua-ethanolic root extracts of Uraria picta Desv. (Fabaceae)","authors":"B. Mohan, H. Saxena, S. Parihar, A. Kakkar","doi":"10.22271/tpi.2020.v9.i7g.4973","DOIUrl":"https://doi.org/10.22271/tpi.2020.v9.i7g.4973","url":null,"abstract":"This is a first-time study on Gas Chromatography-Mass Spectrometry (GC-MS) determination of phytoconstituents from ethanolic and aqua-ethanolic root extracts of Uraria picta. It is a commercially importance species which is utilized in Dashmoolarishta, an established ayurvedic drug of ISM. GC-MS determined two major phytoconstituents in ethanolic extract as N-Capric acid Isopropyl Ester (RT- 21.397, 60.98%), 9-Octadecenoic acid (Z) -, Hexyl Ester (RT- 23.298, 39.02%) and three compounds in aqua-ethanolic extract namely Propanoic acid, 2- Hydroxy-, Pentyl Ester (RT- 11.697, 81.64%), α - D-Mannofuranoside, 1-Nonyl - (RT- 20.28, 7.87%) and 2-Bromopropionic acid, Penta decyl ester (RT- 21.486, 6.77%). Four phytocompounds investigated from roots in the present study have commercial significance.","PeriodicalId":23030,"journal":{"name":"The Pharma Innovation Journal","volume":"23 1","pages":"463-467"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86069505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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