The case report describes a rare case of pneumoperitoneum occurred in a 23-year-old man following intentional ingestion of liquid butane. No gastrointestinal perforation was identified during surgery, and the clinical course was favorable with complete recovery after conservative surgical management.
{"title":"Pneumoperitoneum after butane ingestion without perforation: Case report and literature review","authors":"Hibat-errahmane Redouane , Khaoula Kouloughli , Assia Yamoun , Khaled Sahli , Khadidja Taibi , Kamel Bouchenak , Sara Abdennour","doi":"10.1016/j.toxac.2025.08.003","DOIUrl":"10.1016/j.toxac.2025.08.003","url":null,"abstract":"<div><div>The case report describes a rare case of pneumoperitoneum occurred in a 23-year-old man following intentional ingestion of liquid butane. No gastrointestinal perforation was identified during surgery, and the clinical course was favorable with complete recovery after conservative surgical management.</div></div>","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 4","pages":"Pages 435-437"},"PeriodicalIF":1.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145546759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-08DOI: 10.1016/j.toxac.2025.07.003
Pascal Kintz , Laurie Gheddar
{"title":"Pas de transfert d’anabolisants stéroïdiens entre les cheveux de 2 partenaires intimes dont l’un est un consommateur excessif","authors":"Pascal Kintz , Laurie Gheddar","doi":"10.1016/j.toxac.2025.07.003","DOIUrl":"10.1016/j.toxac.2025.07.003","url":null,"abstract":"","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 4","pages":"Pages 405-407"},"PeriodicalIF":1.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145546818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-25DOI: 10.1016/j.toxac.2025.07.002
Paméla Dugues , Abderrahmane Rabai , Sevag Chenorhokian , Gregory Pfau , Sabrina Cherki , Marie Bellouard , Jean Claude Alvarez , Islam Amine Larabi
Background
Nitazenes, a class of synthetic opioids more potent than fentanyl, have been increasingly detected in the global illicit drug market, particularly within counterfeit medicines, causing intoxication and death. They represent a significant public health concern due to their high toxicity and their invisibility to conventional toxicological screening methods.
Methods
Five counterfeit oxycodone tablets were collected in Paris by a drug-checking service between February and May 2025. Visual inspection indicated the tablets mimicked authentic oxycodone “M30” formulations. Two tablets were received intact and three in powder form (ground beforehand). Analytical testing was conducted using LC-DAD, GC-MS, LC-MS/MS, and LC-HRMS. Quantification was performed by LC-MS/MS for 340 substances, including 163 new psychoactive substances (NPS).
Results
No oxycodone was detected in any of the samples; instead, all contained the synthetic opioids metonitazene and protonitazene. Quantification showed that tablets contained between 3.2% and 6.0% metonitazene, with protonitazene present in smaller amounts (less than 0.2%). The estimated metonitazene content in intact tablets (n = 2) ranged from 3.7 to 4.0 mg, approximately equivalent to 23 mg of fentanyl, far exceeding lethal thresholds.
Conclusion
These findings confirm the circulation of synthetic opioids in counterfeit tablets sold as oxycodone in Paris and its suburbs. The presence of multiple nitazenes underscores the complexity and risk of the current illicit market. Drug-checking services and toxicological analyses are essential for early detection and public health response. Enhanced surveillance, harm reduction, and regulatory coordination are urgently required to mitigate the growing threat of nitazene-related poisonings worldwide.
{"title":"Emergence of counterfeit oxycodone tablets containing Nitazenes in France: First national alert and analytical characterization","authors":"Paméla Dugues , Abderrahmane Rabai , Sevag Chenorhokian , Gregory Pfau , Sabrina Cherki , Marie Bellouard , Jean Claude Alvarez , Islam Amine Larabi","doi":"10.1016/j.toxac.2025.07.002","DOIUrl":"10.1016/j.toxac.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Nitazenes, a class of synthetic opioids more potent than fentanyl, have been increasingly detected in the global illicit drug market, particularly within counterfeit medicines, causing intoxication and death. They represent a significant public health concern due to their high toxicity and their invisibility to conventional toxicological screening methods.</div></div><div><h3>Methods</h3><div>Five counterfeit oxycodone tablets were collected in Paris by a drug-checking service between February and May 2025. Visual inspection indicated the tablets mimicked authentic oxycodone “M30” formulations. Two tablets were received intact and three in powder form (ground beforehand). Analytical testing was conducted using LC-DAD, GC-MS, LC-MS/MS, and LC-HRMS. Quantification was performed by LC-MS/MS for 340 substances, including 163 new psychoactive substances (NPS).</div></div><div><h3>Results</h3><div>No oxycodone was detected in any of the samples; instead, all contained the synthetic opioids metonitazene and protonitazene. Quantification showed that tablets contained between 3.2% and 6.0% metonitazene, with protonitazene present in smaller amounts (less than 0.2%). The estimated metonitazene content in intact tablets (<em>n</em> <!-->=<!--> <!-->2) ranged from 3.7 to 4.0<!--> <!-->mg, approximately equivalent to 23<!--> <!-->mg of fentanyl, far exceeding lethal thresholds.</div></div><div><h3>Conclusion</h3><div>These findings confirm the circulation of synthetic opioids in counterfeit tablets sold as oxycodone in Paris and its suburbs. The presence of multiple nitazenes underscores the complexity and risk of the current illicit market. Drug-checking services and toxicological analyses are essential for early detection and public health response. Enhanced surveillance, harm reduction, and regulatory coordination are urgently required to mitigate the growing threat of nitazene-related poisonings worldwide.</div></div>","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 4","pages":"Pages 529-539"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145546938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-08DOI: 10.1016/j.toxac.2025.06.003
Jean-Claude Alvarez
{"title":"Les sportifs doivent ils devenir pharmacologue pour éviter les résultats analytiques anormaux lors des tests anti-dopage ?","authors":"Jean-Claude Alvarez","doi":"10.1016/j.toxac.2025.06.003","DOIUrl":"10.1016/j.toxac.2025.06.003","url":null,"abstract":"","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 3","pages":"Pages 265-267"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fluoride has been widely used since the 1950s, especially in dental medicine to prevent cavities. However, excessive levels can lead to fluorosis, affecting teeth and bones, with prevalence varying by region and socio-economic status. This study assessed fluoride exposure and the risk of dental and skeletal fluorosis in Biskra, El Oued, and Constantine by analyzing intake sources such as drinking water, dates, tea infusions, and fluoride levels in teeth. A retrospective study was conducted in Constantine, where water, tea, dates, and teeth samples were collected and analyzed using a colorimetric method. Results showed that tap water in Biskra exceeded WHO-recommended fluoride levels, with significantly higher concentrations than in Constantine and El Oued. Spring water in Biskra also showed elevated levels, confirming high regional exposure. Dates, especially the Deglet Noor variety, contained 35.7 mg/kg of fluoride, representing a major intake source for Biskra residents. Tea infusions had fluoride concentrations between 1.62 and 2.04 ppm, further contributing to exposure. Dental analysis revealed high fluoride levels in children's teeth in Biskra, averaging 41.06 ppm, markedly higher than in El Oued and Constantine. Women's teeth showed higher fluoride levels than men's, and children under 16 were the most affected, indicating a high risk of dental fluorosis. These findings highlight substantial fluoride exposure in Biskra, mainly from water, dates, and tea, increasing the risk of fluorosis, especially among children. The study underscores the need for targeted monitoring and preventive strategies in affected areas.
{"title":"Risk assessment of fluorosis in the Algerian sub-Saharan region","authors":"Mohamed Habib Belmahi , Imane Mecheri , Khaoula Aouissi , Aissa Dehane , Slimane Merouani","doi":"10.1016/j.toxac.2025.06.002","DOIUrl":"10.1016/j.toxac.2025.06.002","url":null,"abstract":"<div><div><span><span><span>Fluoride has been widely used since the 1950s, especially in dental medicine to prevent cavities. However, excessive levels can lead to fluorosis, affecting teeth and bones, with prevalence varying by region and socio-economic status. This study assessed fluoride exposure and the risk of dental and skeletal fluorosis in Biskra, El Oued, and Constantine by analyzing intake sources such as </span>drinking water, dates, tea infusions, and fluoride levels in teeth. A retrospective study was conducted in Constantine, where water, tea, dates, and teeth samples were collected and analyzed using a </span>colorimetric method<span>. Results showed that tap water in Biskra exceeded WHO-recommended fluoride levels, with significantly higher concentrations than in Constantine and El Oued. Spring water in Biskra also showed elevated levels, confirming high regional exposure. Dates, especially the Deglet Noor variety, contained 35.7</span></span> <!-->mg/kg of fluoride, representing a major intake source for Biskra residents. Tea infusions had fluoride concentrations between 1.62 and 2.04<!--> <!-->ppm, further contributing to exposure. Dental analysis revealed high fluoride levels in children's teeth in Biskra, averaging 41.06<!--> <span>ppm, markedly higher than in El Oued and Constantine. Women's teeth showed higher fluoride levels than men's, and children under 16 were the most affected, indicating a high risk of dental fluorosis. These findings highlight substantial fluoride exposure in Biskra, mainly from water, dates, and tea, increasing the risk of fluorosis, especially among children. The study underscores the need for targeted monitoring and preventive strategies in affected areas.</span></div></div>","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 4","pages":"Pages 520-528"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145546911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Objectif</h3><div>La mifépristone (RU-486), dérivé synthétique de stéroïde, est un antagoniste des récepteurs de la progestérone. Vendue en France sous la dénomination Mifegyne™ (comprimé dosé à 200<!--> <!-->mg), la mifépristone est proposée dans l’interruption thérapeutique de la grossesse, en haut dosage (600<!--> <!-->mg), parfois associée au misoprostol (400 à 600<!--> <!-->μg), un analogue de la prostaglandine. La délivrance de la mifépristone est encadrée et nécessite une prescription médicale. Les auteurs rapportent une administration cachée de mifépristone par un partenaire masculin, ne souhaitant pas d’enfant, à une femme enceinte de 5 semaines. Cette dernière fait une fausse couche à domicile 2 ou 3<!--> <!-->jours après avoir bu des bières sans alcool offertes par son compagnon. Après avoir découvert que son partenaire avait effectué des recherches sur son ordinateur sur la façon de procéder médicalement à une interruption de grossesse, la femme va porter plainte à la gendarmerie.</div></div><div><h3>Matériel et méthode</h3><div>Une mèche de cheveux foncés, de 12<!--> <!-->cm, est prélevée 7 à 8 semaines après les faits. La mifépristone a été recherchée par chromatographie en phase liquide couplée à la spectrométrie de masse en tandem après décontamination, segmentation et incubation dans du méthanol pendant une nuit.</div></div><div><h3>Résultats et discussion</h3><div>Dans le segment 0 à 3<!--> <!-->cm (correspondant à la période des faits), il a été retrouvé de la mifépristone dosée approximativement à 0,8<!--> <!-->pg/mg (concentration inférieure à la limite de quantification qui est à 1<!--> <!-->pg/mg). Cette caractérisation constitue une preuve biologique déterminante pour démontrer une exposition cachée d’une substance nuisible ayant porté atteinte à l’intégrité physique de la femme enceinte.</div></div><div><h3>Conclusion</h3><div>Cette infraction est réprimée par l’article 222-15 du Code pénal, modifié par la loi n<sup>o</sup> 2007-297 du 5 mars 2007.</div></div><div><h3>Aim</h3><div>Mifepristone (RU-486), synthetic steroid, is a progesterone receptors antagonist. In France, mifepristone is available in 200<!--> <!-->mg tablets (Mifegyne ™) and is proposed in case of therapeutic pregnancy termination at high doses (600<!--> <!-->mg), sometimes in association with misoprostol (400 to 600<!--> <!-->μg), a prostaglandine-like substance. Prescription of mifepristone is regulated and delivery in pharmacies requires a medical receipt. The authors report a hidden administration of mifepristone by a male partner who did not want a child to a 5 weeks pregnant woman. She expelled the products of conception 2 to 3 days after having drunk non-alcoholic beers offered by her partner. Having identified on her computer used by the partner specific search for chemical abortion, she went to the gendarmerie to report the crime.</div></div><div><h3>Material and method</h3><div>A bundle of brown hair, measuring 12<!--> <!-->cm, was coll
{"title":"Administration cachée de mifépristone à une femme enceinte par le partenaire dans un but abortif","authors":"Christophe Maruejouls , Frédéric Aknouche , Laurie Gheddar , Pascal Kintz","doi":"10.1016/j.toxac.2025.05.003","DOIUrl":"10.1016/j.toxac.2025.05.003","url":null,"abstract":"<div><h3>Objectif</h3><div>La mifépristone (RU-486), dérivé synthétique de stéroïde, est un antagoniste des récepteurs de la progestérone. Vendue en France sous la dénomination Mifegyne™ (comprimé dosé à 200<!--> <!-->mg), la mifépristone est proposée dans l’interruption thérapeutique de la grossesse, en haut dosage (600<!--> <!-->mg), parfois associée au misoprostol (400 à 600<!--> <!-->μg), un analogue de la prostaglandine. La délivrance de la mifépristone est encadrée et nécessite une prescription médicale. Les auteurs rapportent une administration cachée de mifépristone par un partenaire masculin, ne souhaitant pas d’enfant, à une femme enceinte de 5 semaines. Cette dernière fait une fausse couche à domicile 2 ou 3<!--> <!-->jours après avoir bu des bières sans alcool offertes par son compagnon. Après avoir découvert que son partenaire avait effectué des recherches sur son ordinateur sur la façon de procéder médicalement à une interruption de grossesse, la femme va porter plainte à la gendarmerie.</div></div><div><h3>Matériel et méthode</h3><div>Une mèche de cheveux foncés, de 12<!--> <!-->cm, est prélevée 7 à 8 semaines après les faits. La mifépristone a été recherchée par chromatographie en phase liquide couplée à la spectrométrie de masse en tandem après décontamination, segmentation et incubation dans du méthanol pendant une nuit.</div></div><div><h3>Résultats et discussion</h3><div>Dans le segment 0 à 3<!--> <!-->cm (correspondant à la période des faits), il a été retrouvé de la mifépristone dosée approximativement à 0,8<!--> <!-->pg/mg (concentration inférieure à la limite de quantification qui est à 1<!--> <!-->pg/mg). Cette caractérisation constitue une preuve biologique déterminante pour démontrer une exposition cachée d’une substance nuisible ayant porté atteinte à l’intégrité physique de la femme enceinte.</div></div><div><h3>Conclusion</h3><div>Cette infraction est réprimée par l’article 222-15 du Code pénal, modifié par la loi n<sup>o</sup> 2007-297 du 5 mars 2007.</div></div><div><h3>Aim</h3><div>Mifepristone (RU-486), synthetic steroid, is a progesterone receptors antagonist. In France, mifepristone is available in 200<!--> <!-->mg tablets (Mifegyne ™) and is proposed in case of therapeutic pregnancy termination at high doses (600<!--> <!-->mg), sometimes in association with misoprostol (400 to 600<!--> <!-->μg), a prostaglandine-like substance. Prescription of mifepristone is regulated and delivery in pharmacies requires a medical receipt. The authors report a hidden administration of mifepristone by a male partner who did not want a child to a 5 weeks pregnant woman. She expelled the products of conception 2 to 3 days after having drunk non-alcoholic beers offered by her partner. Having identified on her computer used by the partner specific search for chemical abortion, she went to the gendarmerie to report the crime.</div></div><div><h3>Material and method</h3><div>A bundle of brown hair, measuring 12<!--> <!-->cm, was coll","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 4","pages":"Pages 422-426"},"PeriodicalIF":1.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145546758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentaires sur l’article de Laeticia Leveque… vers une toxicologie discount ?","authors":"Pascal Kintz , Jean-Michel Gaulier , Anne-Laure Pélissier","doi":"10.1016/j.toxac.2025.06.001","DOIUrl":"10.1016/j.toxac.2025.06.001","url":null,"abstract":"","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 3","pages":"Pages 268-269"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Narcotics controls measures are being intensified specially at ski resorts during winter. Over the past decade, the French Alps experienced several cases of fatal accidents at high altitude. This study aims to determine the prevalence of psychoactive substances used in fatal high altitude accidents.
Methods
A 10-year retrospective study was conducted including data from 2014 to 2023. These accidents occurred in the French Alps, within the departments of Haute-Savoie, Savoie, Isère, Hautes-Alpes and a part of Drôme. Only fatal accidents that occurred during high-altitude activities (above 1000 meters), and for which no medical cause of death was identified were included.
Results
Among the selected cases, 99 victims were male and 22 were female, with a median age of 42 years. The most common types of accidents involved skiing/snowboarding, followed by flying in all types of aircraft, sport climbing and outdoor excursions, water sports such as canyoning and kayaking, and other types of high-altitude activities. One hundred and twelve cases were negative, while nine were positive for cannabis consumption, with six individuals being under the influence at the time of death.
Conclusion
In this study, cannabis was the only narcotic detected in fatal high-altitude accidents, demonstrating a prevalence of 5%. This finding suggests that cannabis consumption constitutes an additional risk factor. Targeted prevention programs could be considered to reduce cannabis use during mountain activities.
{"title":"Prevalence of psychoactive substance in fatal high-altitude accidents: A 10-year retrospective study in the French Alps","authors":"Coralie Boudin , Hélène Eysseric-Guérin , François Paysant , Françoise Stanke-Labesque , Virginie Scolan , Théo Willeman","doi":"10.1016/j.toxac.2025.05.004","DOIUrl":"10.1016/j.toxac.2025.05.004","url":null,"abstract":"<div><h3>Aims</h3><div>Narcotics controls measures are being intensified specially at ski resorts during winter. Over the past decade, the French Alps experienced several cases of fatal accidents at high altitude. This study aims to determine the prevalence of psychoactive substances used in fatal high altitude accidents.</div></div><div><h3>Methods</h3><div>A 10-year retrospective study was conducted including data from 2014 to 2023. These accidents occurred in the French Alps, within the departments of Haute-Savoie, Savoie, Isère, Hautes-Alpes and a part of Drôme. Only fatal accidents that occurred during high-altitude activities (above 1000 meters), and for which no medical cause of death was identified were included.</div></div><div><h3>Results</h3><div>Among the selected cases, 99 victims were male and 22 were female, with a median age of 42 years. The most common types of accidents involved skiing/snowboarding, followed by flying in all types of aircraft, sport climbing and outdoor excursions, water sports such as canyoning and kayaking, and other types of high-altitude activities. One hundred and twelve cases were negative, while nine were positive for cannabis consumption, with six individuals being under the influence at the time of death.</div></div><div><h3>Conclusion</h3><div>In this study, cannabis was the only narcotic detected in fatal high-altitude accidents, demonstrating a prevalence of 5%. This finding suggests that cannabis consumption constitutes an additional risk factor. Targeted prevention programs could be considered to reduce cannabis use during mountain activities.</div></div>","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 4","pages":"Pages 513-519"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145546909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-27DOI: 10.1016/j.toxac.2025.05.002
Pascal Kintz
{"title":"De l’importance à ne pas considérer de façon dogmatique que les cheveux poussent de 1 cm par mois","authors":"Pascal Kintz","doi":"10.1016/j.toxac.2025.05.002","DOIUrl":"10.1016/j.toxac.2025.05.002","url":null,"abstract":"","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 3","pages":"Pages 263-264"},"PeriodicalIF":1.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Air pollution has a significant adverse effect on the life expectancy of people worldwide. Exposure to dust storms can adversely affect health, the environment, and economic stability. Research suggests a connection between air quality and increased death rates related to heart issues. Interleukins are important in causing inflammation. This research investigates the link between the amount of PM10 and interleukin-6 levels among healthy individuals in Zahedan.
Materials and method
In this study, sampling was performed using a PQ200/BGI sampler six days a week, including days with dust storms. The study assessed biomarker interleukin-6 levels in blood samples collected from 40 volunteers aged 20 to 35 years using the enzyme-linked immunosorbent assay (ELISA) method.
Results and discussion
The mean concentration of PM10 in the air of Zahedan during the study period was 210.4 μg/m3, indicating elevated levels of PM10, a major air pollutant, surpassing standard levels. Furthermore, the study found that interleukin-6 levels in blood samples collected during air pollution conditions were significantly higher than those in the control group (P-value < 0.05).
Conclusion
When PM10 concentrations exceed the standard limit, these findings emphasize the importance of prioritizing health programs, especially considering the increase in cardiovascular and respiratory diseases, as well as elevated interleukin-6 levels during dust storms.
{"title":"The relationship between biomarker interleukin-6 and particulate matter of dust storms (cohort study in 2024 – Zahedan city)","authors":"Hossein Abdipour , Mehrdad Assadian Narenji , Seyed Ebrahim Seyed Mousavi , Abdolali Khammari , Mohsen Dahghani Ghnataghestani , Ebrahim Alijani , Hossein Kamani , Mehrnaz Hosseinzehi","doi":"10.1016/j.toxac.2025.05.001","DOIUrl":"10.1016/j.toxac.2025.05.001","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Air pollution has a significant adverse effect<span><span> on the life expectancy of people worldwide. Exposure to dust storms can adversely affect health, the environment, and economic stability. Research suggests a connection between air quality and increased </span>death rates<span> related to heart issues. Interleukins are important in causing inflammation. This research investigates the link between the amount of PM</span></span></span><sub>10</sub> and interleukin-6 levels among healthy individuals in Zahedan.</div></div><div><h3>Materials and method</h3><div>In this study, sampling was performed using a PQ200/BGI sampler six days a week, including days with dust storms. The study assessed biomarker interleukin-6 levels in blood samples collected from 40 volunteers aged 20 to 35 years using the enzyme-linked immunosorbent assay (ELISA) method.</div></div><div><h3>Results and discussion</h3><div>The mean concentration of PM<sub>10</sub> in the air of Zahedan during the study period was 210.4<!--> <!-->μg/m<sup>3</sup>, indicating elevated levels of PM<sub>10</sub><span>, a major air pollutant, surpassing standard levels. Furthermore, the study found that interleukin-6 levels in blood samples collected during air pollution conditions were significantly higher than those in the control group (</span><em>P</em>-value<!--> <!--><<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>When PM<sub>10</sub><span> concentrations exceed the standard limit, these findings emphasize the importance of prioritizing health programs, especially considering the increase in cardiovascular and respiratory diseases, as well as elevated interleukin-6 levels during dust storms.</span></div></div>","PeriodicalId":23170,"journal":{"name":"Toxicologie Analytique et Clinique","volume":"37 4","pages":"Pages 504-512"},"PeriodicalIF":1.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145546908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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