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Primaquine-induced hemolysis in a Colombian patient with glucose-6-phosphate dehydrogenase deficiency 一名患有葡萄糖-6-磷酸脱氢酶缺乏症的哥伦比亚患者因普利马喹引起的溶血。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-30 DOI: 10.1016/j.tmaid.2024.102748
Daniel Celis-Giraldo, María Alejandra Fajardo, Diana Camila Romo Arteaga, Álvaro A. Faccini-Martínez
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引用次数: 0
Impact of species hybridization on the clinical management of schistosomiasis: A prospective study 物种杂交对血吸虫病临床治疗的影响:一项前瞻性研究。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-23 DOI: 10.1016/j.tmaid.2024.102744
Joaquín Salas-Coronas , M. Dolores Bargues , Pedro Fernández-Soto , Manuel J. Soriano-Pérez , Patricio Artigas , José Vázquez-Villegas , Antonio Villarejo-Ordoñez , José C. Sánchez-Sánchez , María I. Cabeza-Barrera , Begoña Febrer-Sendra , Alejandra De Elías-Escribano , Beatriz Crego-Vicente , María C. Fantozzi , Juan García-Bernalt Diego , Nerea Castillo-Fernández , Jaime Borrego-Jiménez , Antonio Muro , María P. Luzón-García

Background

Species hybridization represents a real concern in terms of parasite transmission, epidemiology and morbidity of schistosomiasis. It is greatly important to better understand the impact of species hybridization for the clinical management.

Methods

A prospective observational study was carried out in sub-Saharan migrants who were diagnosed with confirmed genitourinary schistosomiasis. A tailored protocol was applied, including Schistosoma serology, a specific urine LAMP tests for schistosomiasis and an ultrasound examination before treatment with praziquantel. A scheduled follow-up was performed at 3, 6 and 12 months to monitor treatment response, comparing patients carriers of Schistosoma hybrids with carriers of only genetically pure forms.

Results

A total of 31 male patients from West Africa were included in the study with a mean age of 26.5 years. Twelve (38.7 %) of the patients were carriers of Schistosoma hybrids. As compared with patients infected with S. haematobium alone, hybrid carriers had lower haemoglobin levels (13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4], p = 0.04), a greater frequency of hematuria (100 % vs 52.6 %, p = 0.005), a higher ultrasound score (2.64, SD 2.20 vs 0.89, SD 0.99; p = 0.02). However, the presence of hybrids did not result in differences in clinical and analytical responses after treatment.

Conclusions

The presence of Schistosoma hybrids seems to cause increased morbidity in infected individuals. However, it does not appear to result in differences in diagnostic tests or in clinical and analytical responses after treatment.

背景:物种杂交是血吸虫病寄生虫传播、流行病学和发病率方面的一个现实问题。更好地了解物种杂交对临床管理的影响非常重要:方法:对确诊患有泌尿生殖系统血吸虫病的撒哈拉以南地区移民进行了一项前瞻性观察研究。在使用吡喹酮治疗前,采用了一套量身定制的方案,包括血吸虫血清学检查、血吸虫特异性尿液 LAMP 检测和超声波检查。在3个月、6个月和12个月时进行定期随访,以监测治疗反应,并将血吸虫杂合型携带者与纯合型携带者进行比较:共有31名来自西非的男性患者参与了研究,他们的平均年龄为26.5岁。其中 12 名患者(38.7%)为血吸虫杂交型携带者。与单纯感染血吸虫的患者相比,血吸虫杂交携带者的血红蛋白水平较低(13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4],p=0.04),出现血尿的频率较高(100% vs 52.6%,p= 0.005),超声波评分较高(2.64,SD 2.20 vs 0.89,SD 0.99;p= 0.02)。然而,杂合体的存在并未导致治疗后临床和分析反应的差异:结论:血吸虫杂交体的存在似乎会增加感染者的发病率。结论:血吸虫杂交体的存在似乎会增加感染者的发病率,但似乎不会导致诊断测试或治疗后临床和分析反应的差异。
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引用次数: 0
Necrotizing mpox with persistent microbiological positivity despite the use of tecovirimat: A case report 尽管使用了替考韦利马特,但微生物呈持续阳性的坏死性麻疹:一份病例报告。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-22 DOI: 10.1016/j.tmaid.2024.102746
Pierluigi Francesco Salvo, Gianmaria Baldin, Elena Visconti, Simona Di Giambenedetto
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引用次数: 0
Association between positive serology for COVID-19 and chagas cardiomyopathy progression: The SaMi-Trop project COVID-19 血清学阳性与南美锥虫病心肌病进展之间的关系:SaMi-Trop项目。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-22 DOI: 10.1016/j.tmaid.2024.102745
Ariela Mota Ferreira , Léa Campos Oliveira-da Silva , Clareci Silva Cardoso , Cláudia Di Lorenzo Oliveira , Bruno Oliveira de Figueiredo Brito , Ana Luiza Bierrenbach , Ana Clara de Jesus Santos , Dardiane Santos Cruz , Sâmara Fernandes Leite , Andréia Brito Jesus , Renata Fiúza Damasceno , Maria Carmo Pereira Nunes , Israel Molina , Desirée Sant’ Anna Haikal , Ester Cerdeira Sabino , Antonio Luiz Pinho Ribeiro

Background

Chagas Disease (CD) can cause Chagas cardiomyopathy. The new coronavirus disease (COVID-19) also affects the cardiovascular system and may worsen Chagas cardiomyopathy. However, the cardiac evolution of patients with CD infected by COVID-19 is not known. Thus, the objective of this study is to assess, within one year, whether there was cardiac progression after COVID-19 in CD.

Methods

Longitudinal study with CD patients. The outcome was cardiac progression, defined as the appearance of new major changes in the current ECG compared to the previous ECG considered from the comparison of electrocardiograms (ECGs) performed with an interval of one year. Positive Anti-SARS-CoV2 Serology was the independent variable of interest. For each analysis, a final multiple model was constructed, adjusted for sociodemographic, clinical, and pandemic-related characteristics.

Results

Of the 404 individuals included, 22.8 % had positive serology for COVID-19 and 10.9 % had cardiac progression. In the final model, positive serology for COVID-19 was the only factor associated with cardiac progression in the group as a whole (OR = 2.65; 95 % CI = 1.27–5.53) and for new-onset cardiomyopathy in the group with normal previous ECG (OR = 3.50; 95 % CI = 1.21–10.13).

Conclusion

Our study shows an association between COVID-19 and progression of Chagas cardiomyopathy, evaluated by repeated ECGs, suggesting that COVID-19 accelerated the natural history of CD.

背景:恰加斯病(CD)可导致恰加斯心肌病。新型冠状病毒病(COVID-19)也会影响心血管系统,并可能加重恰加斯心肌病。然而,受 COVID-19 感染的南美锥虫病患者的心脏演变情况尚不清楚。因此,本研究的目的是评估 CD 患者感染 COVID-19 后一年内是否出现心脏病变:方法:对 CD 患者进行纵向研究。方法:对 CD 患者进行纵向研究,研究结果为心脏进展,其定义是通过比较间隔一年的心电图,发现当前心电图与之前的心电图相比出现了新的重大变化。抗 SARS-CoV2 血清学阳性是自变量。每项分析都建立了最终的多重模型,并对社会人口学、临床和大流行相关特征进行了调整:结果:在纳入的 404 人中,22.8% 的人 COVID-19 血清学检测呈阳性,10.9% 的人有心脏疾病进展。在最终模型中,COVID-19 血清学阳性是唯一与整个群体的心脏病进展相关的因素(OR=2.65;95 % CI=1.27-5.53),也是与既往心电图正常群体的新发心肌病相关的因素(OR=3.50;95 % CI=1.21-10.13):我们的研究显示,通过重复心电图评估,COVID-19与恰加斯心肌病的进展之间存在关联,这表明COVID-19加速了CD的自然病史。
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引用次数: 0
Incidence and clinical significance of non-tuberculous mycobacteria among migrants in Denmark: A nationwide register-based cohort study from 1991 through 2021 丹麦移民中非结核分枝杆菌的发病率和临床意义:1991 年至 2021 年基于全国登记的队列研究。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-10 DOI: 10.1016/j.tmaid.2024.102736

Background

There is limited knowledge about non-tuberculous mycobacteria (NTM) infections in migrants. We aimed to assess the incidence and clinical significance of NTM among migrants in Denmark.

Method

Nationwide register-based cohort study of migrants with a positive NTM culture in Denmark from 1991 through 2021, stratified by patient demographics, disease localisation, species, and clinical significance.

Results

433 migrants had a positive NTM culture, resulting in an overall incidence rate (IR) of 3.7 (95%CI 3.3–4.0) per 100,000 migrants. Overall NTM IRs for definite disease were 1.0 (95%CI 0.9–1.2), possible disease 1.0 (95%CI 0.8–1.2), and isolation 1.7 (95%CI 1.4–1.9) per 100,000 migrants. Migrants had considerably higher age- and sex-adjusted NTM IRs of positive cultures (incidence rate ratio [IRR] = 2.1, 95%CI 1.9–2.3, p < 0.001), possible disease (IRR = 2.4, 95%CI 2.0–3.0, p < 0.001), and isolation (IRR = 4.6, 95%CI 3.9–5.4, p < 0.001) compared to Danish-born, but not of definite disease (IRR = 1.1, 95%CI 0.9–1.3, p = 0.562). IRs of migrants with positive NTM cultures did not increase over time (−0.8 %/year, p = 0.133).

Conclusions

Migrants have a higher, but stable, burden of NTM compared with Danish-born. The higher rates likely reflect that more specimens are examined for Mycobacterium tuberculosis. Microbiologically classified definite NTM disease is not substantially more common among migrants.

背景:有关移民非结核分枝杆菌(NTM)感染的知识有限。我们旨在评估丹麦移民中 NTM 的发病率和临床意义:方法:对1991年至2021年期间在丹麦NTM培养呈阳性的移民进行全国范围的登记队列研究,按患者人口统计学、疾病定位、种类和临床意义进行分层:433名移民的非淋菌性肺结核培养呈阳性,总发病率(IR)为每10万移民3.7例(95%CI 3.3-4.0)。每 10 万名移民中,NTM 确诊病例的总发病率为 1.0(95%CI 0.9-1.2),可能病例为 1.0(95%CI 0.8-1.2),隔离病例为 1.7(95%CI 1.4-1.9)。经年龄和性别调整后,移民的培养阳性非淋菌性肺结核 IRs 要高得多(发病率比 [IRR]=2.1, 95%CI 1.9-2.3, p结论:与丹麦出生的人相比,移民的非淋菌性肺结核发病率较高,但比较稳定。较高的发病率可能反映了更多标本接受了结核杆菌检查。此外,微生物学分类明确的非结核性疾病在移民中并不常见。
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引用次数: 0
Mosquito-borne Murray Valley encephalitis: Re-emergence in Western Australia 蚊媒墨累山谷脑炎:重新出现在西澳大利亚州。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102734
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引用次数: 0
Zika and Chikungunya in Europe 2100 – A GIS based model for risk estimation 2100 年欧洲的寨卡病毒和基孔肯雅病毒--基于地理信息系统的风险评估模型。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102737
J. Kronen , M. Leuchner , T. Küpper

Background

The spread of vector-borne infectious diseases is determined, among other things, by temperature. Thus, climate change will have an influence on their global distribution. In the future, Europe will approach the temperature optimum for the transmission of ZIKV and CHIKV. Climate scenarios and climate models can be used to depict future climatic changes and to draw conclusions about future risk areas for vector-borne infectious diseases.

Methods

Based on the RCP 4.5 and RCP 8.5 climate scenarios, a geospatial analysis was carried out for the future temperature suitability of ZIKV and CHIKV in Europe. The results were presented in maps and the percentage of the affected areas calculated.

Results

Due to rising temperatures, the risk areas for transmission of ZIKV and CHIKV spread in both RCP scenarios. For CHIKV transmission, Spain, Portugal, the Mediterranean coast and areas near the Black Sea are mainly affected. Due to high temperatures, large areas throughout Europe are at risk for ZIKV and CHIKV transmission.

Conclusion

Temperature is only one of many factors influencing the spread of vector-borne infectious diseases. Nevertheless, the representation of risk areas on the basis of climate scenarios allows an assessment of future risk development. Monitoring and adaptation strategies are indispensable for coping with and containing possible future autochthonous transmissions and epidemics in Europe.

背景:病媒传染病的传播主要取决于温度。因此,气候变化将对这些疾病的全球分布产生影响。未来,欧洲将接近 ZIKV 和 CHIKV 传播的最佳温度。气候情景和气候模型可用于描绘未来的气候变化,并就未来病媒传染病的风险区域得出结论:方法:根据 RCP 4.5 和 RCP 8.5 气候情景,对欧洲 ZIKV 和 CHIKV 的未来温度适宜性进行了地理空间分析。分析结果以地图形式呈现,并计算了受影响地区的百分比:结果:由于气温升高,ZIKV 和 CHIKV 传播的风险区域在两种 RCP 情景中都有所扩大。就 CHIKV 传播而言,西班牙、葡萄牙、地中海沿岸和黑海附近地区主要受到影响。由于气温较高,欧洲大部分地区都面临 ZIKV 和 CHIKV 传播的风险:气温只是影响病媒传染病传播的众多因素之一。尽管如此,根据气候情景对风险地区进行描述,可以对未来的风险发展进行评估。要应对和遏制欧洲未来可能出现的自体传播和流行病,监测和适应战略必不可少。
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引用次数: 0
Unexpected discovery of Trypanosoma brucei gambiense on CSF in a western country: About a case 在一个西方国家的脑脊液中意外发现布氏锥虫:关于一个病例。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102741
Lou-Ann Francois, Laurent Bret, Jonathan Wong So, Camelia Gubavu, Feriel Touafek, Morgane Vinsonneau, Khaoula Kochbati, Véronique Avettand-Fenoel, Clemence Guillaume, Etienne Carbonnelle, Jérôme Guinard, Gilbert Mchantaf
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引用次数: 0
Not all severe malaria cases are severe: Is it time to redefine severity criteria for malaria in non-endemic regions? 并非所有重症疟疾病例都是重症:现在是重新定义非疟疾流行地区疟疾严重程度标准的时候了吗?
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102740
Leire Balerdi-Sarasola , Jose Muñoz , Pedro Fleitas , Natalia Rodriguez-Valero , Alex Almuedo-Riera , Alba Antequera , Carme Subirà , Ignacio Grafia-Perez , Maria Ortiz-Fernández , Tessa de Alba , Miriam J. Álvarez-Martínez , M Eugenia Valls , Claudio Parolo , Pedro Castro , Daniel Camprubí-Ferrer

Background

The current definition of severe malaria in non-endemic areas follows WHO criteria, which mainly target children in malaria-endemic areas, potentially misclassifying cases in non-endemic regions. We assessed the performance of a modified severe malaria classification criteria within our patient cohort.

Methods

A cohort study of patients managed for malaria in a non-endemic setting (2005–2023) was analyzed. We classified patients into severe malaria (SM) using WHO 2013 criteria except for hyperparasitemia, where 2 % threshold was applied. Patients with SM were distinguished as very severe malaria (VSM) when presenting at least one of the following conditions: parasitemia >10 %, pulmonary edema, impaired consciousness, seizures, renal failure, metabolic acidosis or hyperlactatemia, shock or hypoglycemia. In patients with SM and no criteria for VSM, less severe malaria (LSM) was defined by: 2–10 % parasitemia, hyperbilirubinemia, prostration, anemia or minor bleeding. The primary composite outcome was death or the need for a life-saving intervention, as analyzed in the three comparative groups. Secondary outcome was the prevalence of co-infections.

Results

Among 506 patients with malaria, 176 (34.8 %) presented with SM. A total of 37 (7.3 %) patients developed a life-threatening condition, namely death (n = 4) and/or the need for life-saving interventions (n = 34). All fatalities and 33 out of the 34 life-saving interventions occurred in the VSM group. Patients in LSM group did not develop any life-threatening conditions. As to co-infections, 28 (5.5 %) patients had a community-acquired co-infection, with no differences between groups (p = 0.763).

Conclusions

Severity criteria definitions would benefit from a review when assessing patients with malaria in non-endemic areas. Within the spectrum of SM, patients reclassified as LSM have a low risk of developing a life-threatening condition and present low co-infection incidence and could benefit from management out of intensive care units and a restrictive use of empirical antibiotics.

背景:目前,非疟疾流行地区重症疟疾的定义遵循世界卫生组织的标准,该标准主要针对疟疾流行地区的儿童,可能会误诊非疟疾流行地区的病例。我们在患者队列中评估了修改后的重症疟疾分类标准的性能:我们对在非疟疾流行地区接受疟疾治疗的患者进行了队列研究(2005-2023 年)。我们采用世界卫生组织 2013 年标准将患者分为重症疟疾 (SM),但高寄生虫血症除外,因为高寄生虫血症的阈值为 2%。重症疟疾患者如果至少出现以下一种情况,即寄生虫血症>10%、肺水肿、意识障碍、癫痫发作、肾功能衰竭、代谢性酸中毒或高乳酸血症、休克或低血糖,则被区分为极重症疟疾(VSM)。对于不符合 VSM 标准的 SM 患者,较轻疟疾(LSM)的定义是:2-10%寄生虫血症、高胆红素血症、衰弱、贫血或轻微出血。三个比较组的主要综合结果是死亡或需要救生干预。次要结果是合并感染的发生率:在 506 名疟疾患者中,176 人(34.8%)患有 SM。共有 37 名(7.3%)患者出现危及生命的情况,即死亡(4 人)和/或需要采取救生措施(34 人)。所有死亡病例和 34 次抢救中的 33 次都发生在 VSM 组。LSM组患者没有出现任何危及生命的情况。在合并感染方面,28(5.5%)名患者合并社区获得性感染,组间无差异(P=0.763):结论:在评估非疟疾流行地区的疟疾患者时,对严重程度标准定义进行审查将是有益的。在疟疾严重程度的范围内,被重新分类为低度严重程度的患者出现危及生命的情况的风险较低,合并感染的发生率也较低,可以从重症监护室外的管理和限制使用经验性抗生素中获益。
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引用次数: 0
Communicable diseases in Ukraine during the period of 2018–2023: Impact of the COVID-19 pandemic and war 2018-2023 年期间乌克兰的传染病:COVID-19 大流行和战争的影响。
IF 6.3 3区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-07-01 DOI: 10.1016/j.tmaid.2024.102733
Pavlo Petakh , Viktoriia Tymchyk , Oleksandr Kamyshnyi

Background

By examining 2018–2023 data, this study explored the intricate impact of the Russian invasion, ongoing COVID-19 pandemic, and environmental disruptions on communicable diseases in Ukraine. This conflict exacerbates challenges in disease surveillance and healthcare, compounding stress among the population.

Methods

Leveraging the Centers for Disease Prevention Control's surveillance system, the study employs active and passive surveillance, utilizing medical records and laboratory reports. Notification rates gauge the incidence of communicable diseases, offering insights into trends during the study period.

Results

While salmonellosis, shigellosis, and rotavirus incidence are decreasing overall, there is a surge in viral hepatitis A, chronic hepatitis B, and C. This conflict hampers hepatitis C management, as evidenced by decreased numbers of treatment centers and patient enrollment. The prevalence of cough cases will increase in 2023, emphasizing the importance of sustained vaccination. The incidence of tuberculosis will increase in 2023 despite a general decrease.

Conclusion

This study underscores the urgent need for sustained efforts and adequate resources, infrastructure, and international support to mitigate public health challenges in conflict-ridden Ukraine. Prioritizing vaccination programmes and enhancing healthcare accessibility in affected regions are crucial.

背景:通过研究 2018-2023 年的数据,本研究探讨了俄罗斯入侵、COVID-19 大流行和环境干扰对乌克兰传染病的复杂影响。这场冲突加剧了疾病监测和医疗保健方面的挑战,加重了民众的压力:这项研究利用疾病预防控制中心的监测系统,通过医疗记录和实验室报告进行主动和被动监测。结果:虽然沙门氏菌病、志贺氏菌病和痢疾的发病率有所下降,但沙门氏菌病、志贺氏菌病和痢疾的发病率却有所上升:虽然沙门氏菌病、志贺氏菌病和轮状病毒的发病率总体上在下降,但甲型病毒性肝炎、慢性乙型肝炎和丙型肝炎的发病率却在激增。2023 年,咳嗽病例的发病率将上升,这强调了持续接种疫苗的重要性。尽管结核病发病率普遍下降,但 2023 年仍将上升:本研究强调,在冲突频发的乌克兰,迫切需要持续的努力、充足的资源、基础设施和国际支持,以缓解公共卫生挑战。在受影响地区优先实施疫苗接种计划和提高医疗服务的可及性至关重要。
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引用次数: 0
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Travel Medicine and Infectious Disease
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