Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9545
D. Gorai
The chemical investigation of methanol extract of the aerial parts of P. pterocarpum belonging to the family Leguminosae led to the isolation of an isoflavone, mexitin. The isolated compound was characterized using various spectroscopic data as well as chemical studies.
{"title":"AN ISOFLAVONE FROM PELTOPHORUM PTEROCARPUM","authors":"D. Gorai","doi":"10.20959/WJPR201711-9545","DOIUrl":"https://doi.org/10.20959/WJPR201711-9545","url":null,"abstract":"The chemical investigation of methanol extract of the aerial parts of P. pterocarpum belonging to the family Leguminosae led to the isolation of an isoflavone, mexitin. The isolated compound was characterized using various spectroscopic data as well as chemical studies.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"61 1","pages":"718-722"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83697320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9614
Mangal Sain Hooda
Salvadora persica has been widely used for its reported biological activity in indigenous system of medicines. The main objective of the present investigation is to evaluate the analgesic activity of hydroalcoholic extract of Salvadora persica root on mice. Analgesic activity of hydro-alcoholic extract of Salvadora persica root at a dose of 100 mg/Kg, 200 mg /Kg and 400 mg /Kg were evaluated against drug pentazocine at a dose of 17.5 mg/Kg. Adult albino mice and rats of either sex of six numbers in each group were under taken for study and evaluated by eddy’s hot plate and tail immersion method. The all doses of Salvadora persica root crude hydro-alcoholic extract were found to produce significant (P<0.05) analgesic activity. In eddy’s hot plate and tail immersion, both method showed significant activity (P<0.05) after 30 minutes. The result showed significant analgesic activity against stimuli.
{"title":"ANALGESIC ACTIVITY OF CRUDE HYDRO-ALCOHOLIC EXTRACT OF SALVADORA PERSICA ROOT","authors":"Mangal Sain Hooda","doi":"10.20959/wjpr201711-9614","DOIUrl":"https://doi.org/10.20959/wjpr201711-9614","url":null,"abstract":"Salvadora persica has been widely used for its reported biological activity in indigenous system of medicines. The main objective of the present investigation is to evaluate the analgesic activity of hydroalcoholic extract of Salvadora persica root on mice. Analgesic activity of hydro-alcoholic extract of Salvadora persica root at a dose of 100 mg/Kg, 200 mg /Kg and 400 mg /Kg were evaluated against drug pentazocine at a dose of 17.5 mg/Kg. Adult albino mice and rats of either sex of six numbers in each group were under taken for study and evaluated by eddy’s hot plate and tail immersion method. The all doses of Salvadora persica root crude hydro-alcoholic extract were found to produce significant (P<0.05) analgesic activity. In eddy’s hot plate and tail immersion, both method showed significant activity (P<0.05) after 30 minutes. The result showed significant analgesic activity against stimuli.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"111 1","pages":"895-902"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78412971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9579
Sulochana Mudgulkar Bhimsen
Thermo-alkali tolerant strain isolated from banana fields produced high levels of inulinase with banana peel as carbon source and showed good growth at pH 6.5 to 9.5 and 40oC to 65oC. It was identified as Stenotrophomonas maltophilia PSSB7 by 16S rDNA analysis, and it is deposited in NCL, Pune with strain number-NCIM 5323, with the accession numberFJ707375. The optimal parameters for the production of inulinase was as follows: pH 8.0, temp 45°C, higher levels of inulinase (5551± 4.583 U/L) was achieved with 1% of banana peel. And was found to be the best carbon source and the effect of different substrates influenced the biosynthesis of inulinase indicating its role as a constitutive enzyme in our strain. Sodium nitrate a best nitrogen source and Mn+ was found to be the most suitable one. All these conditions make it a potential strain for the industrial production from agro based wastes.
{"title":"PRODUCTION OF INULINASE BY THERMO-ALKALI TOLERANT STENOTROPHOMONAS MALTOPHILIA PSSB7 ISOLATED FROM AGRO-WASTES","authors":"Sulochana Mudgulkar Bhimsen","doi":"10.20959/wjpr201711-9579","DOIUrl":"https://doi.org/10.20959/wjpr201711-9579","url":null,"abstract":"Thermo-alkali tolerant strain isolated from banana fields produced high levels of inulinase with banana peel as carbon source and showed good growth at pH 6.5 to 9.5 and 40oC to 65oC. It was identified as Stenotrophomonas maltophilia PSSB7 by 16S rDNA analysis, and it is deposited in NCL, Pune with strain number-NCIM 5323, with the accession numberFJ707375. The optimal parameters for the production of inulinase was as follows: pH 8.0, temp 45°C, higher levels of inulinase (5551± 4.583 U/L) was achieved with 1% of banana peel. And was found to be the best carbon source and the effect of different substrates influenced the biosynthesis of inulinase indicating its role as a constitutive enzyme in our strain. Sodium nitrate a best nitrogen source and Mn+ was found to be the most suitable one. All these conditions make it a potential strain for the industrial production from agro based wastes.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"102 1","pages":"830-843"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74707566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9525
Y. Bhagyasri
To investigate the phytochemical screening and antioxidant potential of ethanolic and chloroform extract of breynia retusa leaf & stem. The study was done by using various invitro methods such as 1, 1diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (N2O2) and Superoxide radical scavenging assays. Phytochemical screenings were performed by various standard procedures. Ethanolic and chloroform extract of 10-100μg/ml Breynia retusa leaf & stem showed high free radical scavenging activity as evidenced by the low IC50 values in DPPH (26μg/ml), in nitric oxide (31.2μg/ml) and in SOD (25.5μg/ml) radical scavenging assays at the concentration of 100μg/ml. The results of present comprehensive analysis demonstrated that ethanolic extract (100μg/ml) showed more significant anti-oxidant activity than chloroform extract of (100μg/ml) Breynia retusa leaf & stem. Breynia retusa could be used as a viable source of natural antioxidants and might be exploited for functional foods and neutraceutical applications.
{"title":"PHYTOCHEMICAL STUDIES AND IN-VITRO ANTI-OXIDANT ACTIVITY OF BREYNIA RETUSA DENNST","authors":"Y. Bhagyasri","doi":"10.20959/wjpr201711-9525","DOIUrl":"https://doi.org/10.20959/wjpr201711-9525","url":null,"abstract":"To investigate the phytochemical screening and antioxidant potential of ethanolic and chloroform extract of breynia retusa leaf & stem. The study was done by using various invitro methods such as 1, 1diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (N2O2) and Superoxide radical scavenging assays. Phytochemical screenings were performed by various standard procedures. Ethanolic and chloroform extract of 10-100μg/ml Breynia retusa leaf & stem showed high free radical scavenging activity as evidenced by the low IC50 values in DPPH (26μg/ml), in nitric oxide (31.2μg/ml) and in SOD (25.5μg/ml) radical scavenging assays at the concentration of 100μg/ml. The results of present comprehensive analysis demonstrated that ethanolic extract (100μg/ml) showed more significant anti-oxidant activity than chloroform extract of (100μg/ml) Breynia retusa leaf & stem. Breynia retusa could be used as a viable source of natural antioxidants and might be exploited for functional foods and neutraceutical applications.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"58 1","pages":"641-651"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80670894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9520
L. Kumari
Tamaka Shwasa has been mentioned as Pittasmudbhava Vyadhi, caused due to the vitiation of Kapha and Vata Dosha and manifested through Pranvaha Srotasa. Vata predominantly associated with Kapha gets obstructed in the Pranavaha Srotas and gets more aggravated and in turn causes Tamaka Shwasa. Tamaka shwasa can be correlated with Bronchial Asthma. Prevalence of asthma is increasing day by day. Shwasahara yoga has Vatakaphashamaka properties. Till date there is no research work has been carried out regarding scientific evaluation of Shwasahara yoga. The present work has been carried out to standardise the drug to confirm its identity, quality, purity. Shwasahara yoga contains Kantakari, Amalaki and Hingu. Pharmacognostical study reveals starch grains, septate fibers, epicarp cells, pitted vessels, simple and stellate trichomes, stone cells of Kantakari; mesocarp cells, silica deposition, group of scleroids of Amalaki. Analytical study showed 7 spots at 254nm and 3 spots at 366nm.
{"title":"PHARMACOGNOSTICAL AND PHARMACEUTICAL EVALUATION OF SHWASAHARA YOGA IN THE MANAGEMENT OF TAMAKA SHWASA","authors":"L. Kumari","doi":"10.20959/WJPR201711-9520","DOIUrl":"https://doi.org/10.20959/WJPR201711-9520","url":null,"abstract":"Tamaka Shwasa has been mentioned as Pittasmudbhava Vyadhi, caused due to the vitiation of Kapha and Vata Dosha and manifested through Pranvaha Srotasa. Vata predominantly associated with Kapha gets obstructed in the Pranavaha Srotas and gets more aggravated and in turn causes Tamaka Shwasa. Tamaka shwasa can be correlated with Bronchial Asthma. Prevalence of asthma is increasing day by day. Shwasahara yoga has Vatakaphashamaka properties. Till date there is no research work has been carried out regarding scientific evaluation of Shwasahara yoga. The present work has been carried out to standardise the drug to confirm its identity, quality, purity. Shwasahara yoga contains Kantakari, Amalaki and Hingu. Pharmacognostical study reveals starch grains, septate fibers, epicarp cells, pitted vessels, simple and stellate trichomes, stone cells of Kantakari; mesocarp cells, silica deposition, group of scleroids of Amalaki. Analytical study showed 7 spots at 254nm and 3 spots at 366nm.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"38 1","pages":"626-632"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85651257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9559
I. Bunyan
One hundred fifty clinical sample were collected from preterm labor patients with (bacterial vaginosis, urinary tract infection and aborted women) 80, 15, 55 respectively, admitted to Babylon Maternity and pediatric hospital and Al-Hilla Teaching Hospital, at the period from February to October 2016. These high vaginal samples were subjected to different methods of identification of G.vginalis mainly traditional bacteriological methods. It was found that 6 (4%) G.vaginalis isolates were recovered by using selective media and Viteck 2 system where 30 (20%) isolates were recovered dependent on direct extraction to high vaginal swab on molecular level. The screening of the adherence property were carried out to all (6) isolates and showed that all of it were capable to adhere on the epithelial cell then subjected to Metranidazole reduce it. Finally in vitro anti-adherence activity to Metronidazole were studied and the results revealed that all isolates were inhibited by aqueous solution at concentration (5%) which gave results (100%) very effective to eradication adherence, the results proved that is effective on disrupted adherence in the first step.
{"title":"EFFECT OF METRONIDAZOLE ON ADHERENCE PROPERTY OF GARDNERELLA VAGINALIS ISOLATED FROM PRETERM LABOR PATIENTS IN AL-HILLA CITY, IRAQ","authors":"I. Bunyan","doi":"10.20959/WJPR201711-9559","DOIUrl":"https://doi.org/10.20959/WJPR201711-9559","url":null,"abstract":"One hundred fifty clinical sample were collected from preterm labor patients with (bacterial vaginosis, urinary tract infection and aborted women) 80, 15, 55 respectively, admitted to Babylon Maternity and pediatric hospital and Al-Hilla Teaching Hospital, at the period from February to October 2016. These high vaginal samples were subjected to different methods of identification of G.vginalis mainly traditional bacteriological methods. It was found that 6 (4%) G.vaginalis isolates were recovered by using selective media and Viteck 2 system where 30 (20%) isolates were recovered dependent on direct extraction to high vaginal swab on molecular level. The screening of the adherence property were carried out to all (6) isolates and showed that all of it were capable to adhere on the epithelial cell then subjected to Metranidazole reduce it. Finally in vitro anti-adherence activity to Metronidazole were studied and the results revealed that all isolates were inhibited by aqueous solution at concentration (5%) which gave results (100%) very effective to eradication adherence, the results proved that is effective on disrupted adherence in the first step.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"19 1","pages":"103-112"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87136422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9612
D. M. Purohit
{"title":"SYNTHESIS AND BIOLOGICAL SCREENING OF (E)-3-{[(3′- DIFLUOROMETHOXY)-5′-(3″-METHYL)-4″-(2‴, 2‴, 2‴- TRIFLUOROETHOXY)PYRIDIN-2″-YL]METHOXYPHENYL}-1- ARYL-PROP-2-ENE-1-ONES","authors":"D. M. Purohit","doi":"10.20959/wjpr201711-9612","DOIUrl":"https://doi.org/10.20959/wjpr201711-9612","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"24 1","pages":"888-894"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87374060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9610
Akash Jain
Pulsatile Drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, at the right time and in the right amount, as per the pathophysiological needs of the diseases, resulting in increasing patient compliance. Pulsatile Drug Delivery systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, GIT motility, etc. Various techniques are available for the pulsatile delivery like pH dependent systems, time dependent systems, etc. The major challenge in the development of pulsatile drug delivery system is to achieve a rapid drug release after the lag time. A pulse has to be generated in such a way that a complete and rapid drug release is achieved after the lag time so as to match body’s circadian rhythms with the release of drugs. Many of circadian dependent diseases display acute symptoms in early morning hours or in the morning at awakening. In case of cardiovascular diseases, BP is at its lowest during the sleep cycle and rises steeply during the early morning period. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems. A popular class of single-pulse systems is that of rupturable dosage forms. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. KEWORDS: PDDS, Pulsatile Release Techniques, NDDS, Classification. INTRODUCTION Today, a vast amount of literature reports that biological processes are not constant but vary according to time. Although much of drug delivery research has focused on constant drug World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 342-357. Review Article ISSN 2277– 7105 *Corresponding Author
{"title":"A REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM","authors":"Akash Jain","doi":"10.20959/wjpr201711-9610","DOIUrl":"https://doi.org/10.20959/wjpr201711-9610","url":null,"abstract":"Pulsatile Drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, at the right time and in the right amount, as per the pathophysiological needs of the diseases, resulting in increasing patient compliance. Pulsatile Drug Delivery systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, GIT motility, etc. Various techniques are available for the pulsatile delivery like pH dependent systems, time dependent systems, etc. The major challenge in the development of pulsatile drug delivery system is to achieve a rapid drug release after the lag time. A pulse has to be generated in such a way that a complete and rapid drug release is achieved after the lag time so as to match body’s circadian rhythms with the release of drugs. Many of circadian dependent diseases display acute symptoms in early morning hours or in the morning at awakening. In case of cardiovascular diseases, BP is at its lowest during the sleep cycle and rises steeply during the early morning period. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems. A popular class of single-pulse systems is that of rupturable dosage forms. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. KEWORDS: PDDS, Pulsatile Release Techniques, NDDS, Classification. INTRODUCTION Today, a vast amount of literature reports that biological processes are not constant but vary according to time. Although much of drug delivery research has focused on constant drug World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 342-357. Review Article ISSN 2277– 7105 *Corresponding Author","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"66 1","pages":"342-357"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80213592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-8842
M. Damle
{"title":"DEVELOPMENT AND VALIDATIONOF OF STABILITY INDICATING HPLC METHOD FOR DETERMINATION OF TOLTERODINE TARTRATE.","authors":"M. Damle","doi":"10.20959/wjpr201711-8842","DOIUrl":"https://doi.org/10.20959/wjpr201711-8842","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"43 1","pages":"430-441"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87507702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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