Aquatic Toxicology最新文献_第10页

Tributyl phosphate inhibits neurogenesis and motor functions during embryonic development in zebrafish 磷酸三丁酯抑制斑马鱼胚胎发育过程中的神经发生和运动功能。

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2024.107203

Gourav Chakraborty , Bhagyashri Joshi , Kedar Ahire , Chinmoy Patra

Tributyl phosphate (TBP), an organophosphate ester (OPE), is heavily used as a solvent in chemical industries, a plasticizer, and to extract radioactive molecules. Thus, widespread uses of TBP in industrialized countries led to the release of TBP and its metabolites, dibutyl phosphate (DBP) and monobutyl phosphate (MBP), in the environment and were detected in human samples. Accumulating these OPEs over time in humans and aquatic animals may develop toxicological effects. The reports also say TBP passes through the mother-fetal transmission route and may affect embryonic development. However, the impact of TBP and its metabolites on vertebrate development has been poorly studied. Ex-utero development, high fecundity, and optical transparency make the zebrafish a preferred model for toxicological evaluation. Thus, we aim to explore the toxic effects of TBP and its metabolites on aquatic animals using zebrafish as a model organism. Embryos in the chorion were incubated in 10–60 µM test chemicals from 6 to 48 h post fertilization (hpf), and analyzed the adverse effects on embryos. Our study found that 10–20 µM TBP inhibits neural growth, resulting in decreased spontaneous movement frequency and locomotive behavior without altering the overall embryonic growth and muscle functions. In contrast, DBP-treated embryos showed increased spontaneous movement frequency without changing the motor neuron growth and locomotive behavior. Further, in higher concentrations, TBP is teratogenic, and DBP is lethal to the embryos. Altogether, we found that TBP inhibits neurogenesis and motor behavior; however, its metabolite DBP is neuroexcitatory in zebrafish embryos.

磷酸三丁酯（TBP）是一种有机磷酸酯（OPE），在化学工业中被广泛用作溶剂、增塑剂和提取放射性分子。因此，工业化国家对TBP的广泛使用导致TBP及其代谢物磷酸二丁酯（DBP）和磷酸一丁酯（MBP）在环境中释放，并在人类样本中检测到。在人类和水生动物体内长期积累这些OPEs可能会产生毒理学效应。报告还说，TBP通过母婴传播途径，可能影响胚胎发育。然而，TBP及其代谢物对脊椎动物发育的影响研究甚少。体外发育，高繁殖力和光学透明性使斑马鱼成为毒理学评估的首选模型。因此，我们的目的是探讨TBP及其代谢物对水生动物的毒性作用，以斑马鱼为模式生物。受精后6 ~ 48 h，绒毛膜内胚胎在10 ~ 60µM的试验化学品中孵育，分析其对胚胎的不良影响。我们的研究发现，10-20µM TBP抑制神经生长，导致自发运动频率和运动行为降低，但不改变整体胚胎生长和肌肉功能。相比之下，dbp处理的胚胎在不改变运动神经元生长和运动行为的情况下，自发运动频率增加。此外，在较高浓度下，TBP会致畸，DBP对胚胎是致命的。总之，我们发现TBP抑制神经发生和运动行为；然而，其代谢物DBP在斑马鱼胚胎中具有神经兴奋性。

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引用次数: 0

The potential effects of corn cob biochar on mitigating pendimethalin-induced toxicity in Nile tilapia (Oreochromis niloticus): Effects on hematological, biochemical, antioxidant-immune parameters, and histopathological alterations 玉米芯生物炭对尼罗罗非鱼（Oreochromis niloticus）减轻二甲氧甲烷引起的毒性的潜在影响：对血液、生化、抗氧化免疫参数和组织病理学改变的影响。

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2024.107213

Rasha M. Reda , Eman M. Zaki , Ahmed A.A. Aioub , Mohamed M.M. Metwally , Fatma Mahsoub

This study aims to examine the restorative impact of corn cob biochar (CCB) on pendimethalin (PMD)-induced toxicity in Oreochromis niloticus. Fish were divided into four groups: the first control group without treatment, the second group (CCB) exposed to 10 g CCB/L, the third group (PDM) exposed to 0.355 mg PDM/L, and the fourth group (PDM+ CCB) receiving both 0.355 mg PDM/L and 10 g CCB/L for 30 days. PDM exposure resulted in behavioral alterations, low survival rate (73.33 %), hematological and biochemical impairments, increased oxidative stress, suppressed immunity, and histopathological damage in gill, liver, and brain tissues. Co-treatment with CCB significantly alleviated these effects, as evidenced by improved survival rate (88.88 %), hematological, biochemical, and antioxidant-immune parameters and reduced histopathological alterations. In conclusion, CCB demonstrated a promising potential to mitigate PDM-induced toxicity in O. niloticus by enhancing physiological, biochemical, and histological resilience.

本研究旨在研究玉米芯生物炭（CCB）对二甲甲烷（PMD）诱导的nilochromis毒性的恢复作用。鱼被分为四组：第一组未处理，第二组（CCB）暴露于10 g CCB/L，第三组（PDM）暴露于0.355 mg PDM/L，第四组（PDM+ CCB）同时接受0.355 mg PDM/L和10 g CCB/L，持续30天。PDM暴露导致行为改变、低存活率（73.33%）、血液学和生化损伤、氧化应激增加、免疫抑制以及鳃、肝和脑组织的组织病理学损伤。与CCB联合治疗显著缓解了这些影响，证明了生存率（88.88%）、血液学、生化和抗氧化免疫参数的提高以及组织病理学改变的减少。综上所述，CCB通过增强niloticus的生理、生化和组织学恢复力，显示出减轻pdm诱导的毒性的潜力。

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引用次数: 0

Intelligent consensus-based predictions of early life stage toxicity in fish tested in compliance with OECD Test Guideline 210 根据经合组织测试指南210对鱼类生命早期毒性进行基于智能共识的预测

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2024.107216

Souvik Pore , Alexia Pelloux , Anders Bergqvist , Mainak Chatterjee , Kunal Roy

Early life stage (ELS) toxicity testing in fish is a crucial test procedure used to evaluate the long-term effects of a wide range of chemicals, including pesticides, industrial chemicals, pharmaceuticals, and food additives. This test is particularly important for screening and prioritizing thousands of chemicals under the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation. In silico methods can be used to estimate the toxicity of a chemical when no experimental data is available and to reduce the cost, time, and resources involved in the experimentation process. In the present study, we developed predictive Quantitative Structure-Activity Relationship (QSAR) models to assess chronic effects of chemicals on ELS in fish. Toxicity data for ELS in fish was collected from two different sources, i.e. J-CHECK and eChemPortal, which contain robust study summaries of experimental studies performed according to OECD Test Guideline 210. The collected data included two types of endpoints – the No Observed Effect Concentration (NOEC) and the Lowest Observed Effect Concentration (LOEC), which were utilized to develop the QSAR models. Six different partial least squares (PLS) models with various descriptor combinations were created for both endpoints. These models were then employed for intelligent consensus-based prediction to enhance predictability for unknown chemicals. Among these models, the consensus model – 3 (Q²_F1 = 0.71, Q²_F2 = 0.71) and individual model – 3 (Q²_F1 = 0.80, Q²_F2 = 0.79) exhibited most promising results for both the NOEC and LOEC endpoints. Furthermore, these models were validated experimentally using experimental data from nine different industrial chemicals provided by Global Product Compliance (Europe) AB. Lastly, the models were used to screen and prioritize chemicals obtained from the Pesticide Properties (PPDB) and DrugBank databases.

鱼类的早期生命阶段毒性测试是一项关键的测试程序，用于评估各种化学品的长期影响，包括杀虫剂、工业化学品、药品和食品添加剂。该测试对于根据化学品注册，评估，授权和限制（REACH）法规筛选和优先考虑数千种化学品尤为重要。在没有实验数据的情况下，计算机方法可用于估计化学物质的毒性，并减少实验过程中涉及的成本、时间和资源。在本研究中，我们建立了预测定量构效关系（QSAR）模型来评估化学物质对鱼类ELS的慢性影响。鱼类中ELS的毒性数据是从两个不同的来源收集的，即J-CHECK和eChemPortal，其中包含根据经合组织测试指南210进行的实验研究的可靠研究摘要。收集的数据包括两种类型的终点-无观测效应浓度（NOEC）和最低观测效应浓度（LOEC），用于建立QSAR模型。为两个端点创建了具有不同描述符组合的六个不同的偏最小二乘（PLS）模型。然后将这些模型用于基于共识的智能预测，以提高对未知化学物质的可预测性。在这些模型中，共识模型- 3 （Q2F1 = 0.71, Q2F2 = 0.71）和个体模型- 3 （Q2F1 = 0.80, Q2F2 = 0.79）对NOEC和LOEC端点都显示出最有希望的结果。此外，使用Global Product Compliance (Europe) AB提供的九种不同工业化学品的实验数据对这些模型进行了实验验证。最后，这些模型用于筛选和优先考虑从农药属性（PPDB）和DrugBank数据库中获得的化学品。

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引用次数: 0

Neurodevelopmental toxicity and mechanism of action of monoethylhexyl phthalate (MEHP) in the developing zebrafish (Danio rerio) 邻苯二甲酸一乙基己基酯（MEHP）对发育中的斑马鱼的神经发育毒性及作用机制

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2024.107230

Chaoqiong Wu , Guanghua Mao , Xiang Ji , Yao Chen , Xin Geng , Emmanuel Sunday Okeke , Yangyang Ding , Liuqing Yang , Xiangyang Wu , Weiwei Feng

Monoethylhexyl phthalate (MEHP) is the primary metabolite of di(2-ethylhexyl) phthalate (DEHP), the most prevalent phthalate plasticiser globally. It has been demonstrated that MEHP exerts more potent toxic effects than DEHP. Nevertheless, the full extent of the toxicity of MEHP to neurodevelopmental organisms remains unclear. Accordingly, the present study was designed to investigate the neurodevelopmental toxicity of MEHP exposure and the underlying molecular mechanisms. Zebrafish juveniles were exposed to different concentrations of MEHP (7.42, 14.84, 29.68 and 74.2 μg/L) for a period of four weeks. Immunohistological evidence indicated that MEHP exposure resulted in oxidative stress and apoptosis in the developing zebrafish brain. Subsequently, the neurobehaviour of zebrafish larvae was evaluated, and it was determined that MEHP significantly disrupted their locomotor capacity, motor vigor, and social conduct. Furthermore, HE staining revealed damage to brain neurons, which may be linked to impaired synthesis and conduction of inter-synaptic neurotransmitters. Transcriptomic analyses indicated that MEHP may affect the expression levels of genes in the P53 signalling pathway and signalling pathways related to the development of the nervous system. This results in impaired functions, including nerve conduction and neuronal development. Additionally, it induces oxidative stress, which leads to significant brain cell apoptosis and, ultimately, neurotoxicity in developing zebrafish.

邻苯二甲酸一乙基己基酯（MEHP）是邻苯二甲酸二（2-乙基己基）酯（DEHP）的主要代谢物，邻苯二甲酸二酯（DEHP）是全球最普遍的邻苯二甲酸酯增塑剂。已经证明，MEHP比DEHP具有更强的毒性作用。然而，MEHP对神经发育生物体的毒性程度仍不清楚。因此，本研究旨在探讨MEHP暴露的神经发育毒性及其潜在的分子机制。将斑马鱼幼鱼暴露于不同浓度的MEHP（7.42、14.84、29.68和74.2 μg/L）中4周。免疫组织学证据表明，MEHP暴露导致发育中的斑马鱼大脑氧化应激和细胞凋亡。随后，对斑马鱼幼虫的神经行为进行了评估，确定MEHP显著破坏了斑马鱼的运动能力、运动活力和社会行为。此外，HE染色显示脑神经元损伤，这可能与突触间神经递质的合成和传导受损有关。转录组学分析表明，MEHP可能影响P53信号通路及神经系统发育相关信号通路基因的表达水平。这导致功能受损，包括神经传导和神经元发育。此外，它还会诱导氧化应激，从而导致脑细胞凋亡，并最终导致发育中的斑马鱼的神经毒性。

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引用次数: 0

Impacts of microplastic accumulation in aquatic environment: Physiological, eco-toxicological, immunological, and neurotoxic effects 水生环境中微塑料积累的影响：生理、生态毒理学、免疫学和神经毒性效应

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2024.107232

Eram Rashid , Syed Makhdoom Hussain , Shafaqat Ali , Muhammad Munir , Abdul Ghafoor , Ebru Yilmaz , Mohammed Ali Alshehri , Danish Riaz , Adan Naeem , Eman Naeem

The presence of microplastics (MPs) in aquatic ecosystem has become a pressing global concern. MPs pose a significant threat to aquatic ecosystems, with devastating consequences for both aquatic life and human health. Notably, freshwater ecosystems are particularly vulnerable to MPs pollution. MPs, characterized by their small size (< 5 mm), have emerged as a ubiquitous environmental pollutant. They exhibit diverse characteristics, including varying sizes, forms, polymer types, and colors. Two distinct categories of MPs exist: primary and secondary. Primary MPs are incorporated into industrial hard materials, cosmetics, and hand cleaners, whereas secondary MPs result from the breakdown of larger plastic products in both terrestrial and marine environments. They enter the environment through various sources, such as household products, clothing, industrial activities, sewage waste and plastic degradation. Aquatic organisms ingest these contaminants, facilitating the transfer of MPs into the food chain and potentially causing severe health problems. This review delves into the bioaccumulation of MPs in fish, highlighting the eco-toxicological, neurological and immunological effects. This review provides an in-depth analysis of innovative solutions for MPs removal and reduction. Finally, we delineate evidence-based strategies to mitigate impacts of MPs, offering valuable insights to inform policy formulations and accelerate the development of sustainable plastic technologies.

微塑料在水生生态系统中的存在已成为一个紧迫的全球性问题。MPs对水生生态系统构成重大威胁，对水生生物和人类健康造成毁灭性后果。值得注意的是，淡水生态系统特别容易受到MPs污染的影响。MPs，其特点是体积小(<；5毫米)，已成为一种无处不在的环境污染物。它们表现出不同的特征，包括不同的尺寸、形状、聚合物类型和颜色。MPs有两种不同的类型：初级和次级。初级MPs被纳入工业硬材料、化妆品和洗手液中，而次级MPs则来自陆地和海洋环境中较大的塑料产品的分解。它们通过各种来源进入环境，如家用产品、服装、工业活动、污水废物和塑料降解。水生生物摄取这些污染物，促进MPs进入食物链，并可能造成严重的健康问题。本文综述了MPs在鱼类体内的生物积累，重点介绍了其生态毒理学、神经学和免疫学效应。这篇综述深入分析了MPs去除和减少的创新解决方案。最后，我们描述了基于证据的策略，以减轻MPs的影响，为政策制定提供有价值的见解，并加速可持续塑料技术的发展。

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引用次数: 0

CLSSATP: Contrastive learning and self-supervised learning model for aquatic toxicity prediction 水生毒性预测的对比学习和自监督学习模型

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2025.107244

Ye Lin , Xin Yang , Mingxuan Zhang , Jinyan Cheng , Hai Lin , Qi Zhao

As compound concentrations in aquatic environments increase, the habitat degradation of aquatic organisms underscores the growing importance of studying the impact of chemicals on diverse aquatic populations. Understanding the potential impacts of different chemical substances on different species is a necessary requirement for protecting the environment and ensuring sustainable human development. In this regard, deep learning methods offer significant advantages over traditional experimental approaches in terms of cost, accuracy, and generalization ability. This research introduces CLSSATP, an efficient contrastive self-supervised learning deep neural network prediction model for organic toxicity. The model integrates two modules, a self-supervised learning module using molecular fingerprints for representation, and a contrastive learning module utilizing molecular graphs. Through dual-perspective learning, the model gains clear insights into the structural and property relationships of molecules. The experiment results indicate that our model outperforms comparative methods, demonstrating the effectiveness of our proposed architecture. Moreover, ablation experiments show that the self-supervised module and contrastive learning module respectively provide average performance improvements of 9.43 % and 10.98 % to CLSSATP. Furthermore, by visualizing the representations of our model, we observe that it correctly identifies the substructures that determine the molecular properties, granting itself with interpretability. In conclusion, CLSSATP offers a novel and effective perspective for future research in aquatic toxicity assessment. All of codes and datasets are freely available online at https://github.com/zhaoqi106/CLSSATP.

随着水生环境中化合物浓度的增加，水生生物栖息地的退化凸显了研究化学品对不同水生种群影响的重要性。了解不同化学物质对不同物种的潜在影响是保护环境和确保人类可持续发展的必要条件。在这方面，深度学习方法在成本、准确性和泛化能力方面比传统的实验方法具有显著的优势。本文介绍了一种高效的对比自监督学习深度神经网络预测模型CLSSATP。该模型集成了两个模块，一个是使用分子指纹表示的自监督学习模块，另一个是使用分子图的对比学习模块。通过双视角学习，该模型对分子的结构和性质关系有了清晰的认识。实验结果表明，我们的模型优于比较方法，证明了我们提出的体系结构的有效性。此外，烧蚀实验表明，自监督模块和对比学习模块对CLSSATP的平均性能分别提高了9.43%和10.98%。此外，通过可视化我们模型的表示，我们观察到它正确地识别了决定分子性质的子结构，赋予其可解释性。综上所述，CLSSATP为今后的水生毒性评价研究提供了一个新颖有效的视角。所有的代码和数据集都可以在https://github.com/zhaoqi106/CLSSATP上免费获得。

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引用次数: 0

Single and combined chronic toxicity of cadmium and titanium dioxide nanoparticles in Aquarana catesbeiana (Anura: Ranidae) tadpoles 镉和二氧化钛纳米颗粒对中华水藻蝌蚪的单一和联合慢性毒性研究

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2025.107246

Carolina Arantes de Moraes , Fagner Neves Oliveira , Gabriel Qualhato , Pedro Vale de Azevedo Brito , Karina Simões , Thiago Lopes Rocha , Raquel Fernanda Salla , Lucélia Gonçalves Vieira

The rising production and improper disposal of titanium dioxide nanoparticles (TiO₂ NPs) into aquatic systems present considerable environmental challenges, especially when these particles interact with other contaminants such as cadmium (Cd). Thus, the current study aimed to evaluate the potential toxic effects on the gills, chondrocranium, body growth, and mortality of Aquarana catesbeiana tadpoles. The tadpoles were exposed to environmentally relevant concentrations of TiO₂ NPs (10 µg L^-1), and CdCl₂ (10 µg L^-1), both individually and in combination, for 30 days (chronic exposure), along with a control group. Our results indicate that the co-exposure to TiO₂ NPs and Cd induced a higher mortality rate. In the gills, TiO₂ NPs led to epithelial simplification, while Cd exposure resulted in stratified epithelium formation. Additionally, there were notable changes in the index of degenerative alterations for the co-exposed group and the overall organ index for the groups exposed to Cd and the mixture. The viscerocranium showed significant malformations in the ceratobranchials and reticular processes, indicating the mixture's toxicological potential during the skeletal system's development. Morphometric analysis also revealed reduced body length and abnormal body ratios in tadpoles from the co-exposure group. In conclusion, TiO₂ NPs and Cd, both alone and in combination, exhibit toxicological effects in A. catesbeiana tadpoles, indicating a potential ecological risk associated with releasing these contaminants into aquatic environments.

二氧化钛纳米颗粒（TiO2 NPs）在水生系统中的生产和处置不当带来了相当大的环境挑战，特别是当这些颗粒与镉（Cd）等其他污染物相互作用时。因此，本研究的目的是评估潜在的毒性作用对鳃、软骨头盖骨、身体生长和死亡的Aquarana catesbeiana蝌蚪。将蝌蚪单独或联合暴露于与环境相关浓度的TiO2 NPs（10µg L-1）和CdCl2（10µg L-1）中30天（慢性暴露），并与对照组一起。我们的研究结果表明，TiO2 NPs和Cd共暴露可导致较高的死亡率。在鳃中，TiO2 NPs导致上皮简化，而Cd暴露导致分层上皮形成。此外，共暴露组的退行性改变指数以及Cd和混合物暴露组的整体器官指数均有显著变化。结果表明，该混合物在骨骼系统发育过程中具有潜在的毒理学作用。形态计量学分析还显示，共同暴露组的蝌蚪体长缩短，身体比例异常。综上所述，TiO2 NPs和Cd单独或联合对中华绒螯虾蝌蚪具有毒性作用，表明将这些污染物释放到水生环境中可能存在潜在的生态风险。

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引用次数: 0

Exploring the combined toxicity of boron nitride nanosheets, cadmium and natural organic matter on Daphnia magna 氮化硼纳米片、镉和天然有机物对大水蚤的联合毒性研究。

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2024.107198

Gabriela Helena da Silva , Jing Ji , Marcella Torres Maia , Davide Mattia , Diego Stéfani Teodoro Martinez

The increase in anthropogenic activities has led to the release of numerous chemicals and pollutants into aquatic ecosystems, raising significant concerns for water quality and health. Among the emerging issues is the interaction between pollutants and nanomaterials (mixture effects). In this work, it was studied the combined toxicity of boron nitride nanosheets (BNNS) and cadmium (Cd²⁺) incorporating the influence of natural organic matter (NOM) to enhance ecological relevance for the first time. Colloidal stability studies showed that BNNS is highly unstable, aggregating and precipitating over time in mineral reconstituted water. However, the addition of natural organic matter stabilizes BNNS. Acute toxicity results showed that this material has a good biocompatibility with D. magna, not causing acute toxic effect (immobility) even at high concentration (100 mg L⁻¹). Moreover, when combined with cadmium, BNNS exhibited a "Trojan horse" effect, enhancing Cd²⁺ toxicity by facilitating its uptake at 1 mg L⁻¹. 48h-EC₅₀ values of Cd²⁺ and BNNS+Cd²⁺ were 0.21 and 0.14 mg L⁻¹, respectively. Nevertheless, NOM (10 mg L⁻¹) mitigated this combined toxicity effect after 48 h of exposure. These findings provide novel insights into nanomaterial-pollutant interactions linked to toxicological effects in aquatic environments, contributing to the risk assessment for the safe and sustainable development of the emerging boron nitride nanomaterials and novel products.

人为活动的增加导致大量化学物质和污染物进入水生生态系统，引起了对水质和健康的重大关切。其中一个新出现的问题是污染物和纳米材料之间的相互作用（混合效应）。本文首次研究了氮化硼纳米片（BNNS）和镉（Cd2+）的联合毒性，并结合天然有机质（NOM）的影响，增强了生态相关性。胶体稳定性研究表明，BNNS是高度不稳定的，随着时间的推移在矿物再造水中聚集和沉淀。然而，天然有机物的加入稳定了BNNS。急性毒性实验结果表明，该材料与D. magna具有良好的生物相容性，即使在高浓度（100 mg L-1）下也不会产生急性毒性作用（不动）。此外，当与镉结合时，BNNS表现出“特洛伊木马”效应，通过促进其在1 mg L-1时的吸收来增强Cd2+的毒性。Cd2+和BNNS+Cd2+ 48h-EC50值分别为0.21和0.14 mg L-1。然而，在暴露48小时后，NOM （10 mg L-1）减轻了这种联合毒性效应。这些发现为水生环境中纳米材料与污染物相互作用的毒理学效应提供了新的见解，有助于对新兴氮化硼纳米材料和新产品的安全和可持续发展进行风险评估。

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引用次数: 0

Modeling the spatiotemporal distribution, bioaccumulation, and ecological risk assessment of microplastics in aquatic ecosystems: A review 水生生态系统中微塑料的时空分布、生物积累和生态风险评估研究进展

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2024.107210

Tianyu Zhuo , Beibei Chai , Xue-yi You

Microplastic (MP) pollution poses a significant threat to aquatic ecosystems. Numerical modeling has emerged as an effective tool for predicting the distribution, accumulation, and risk assessment of MPs in aquatic ecosystems. However, published work has not systematically assessed the strengths and weaknesses of various modeling approaches. Therefore, we conducted a thorough review of the main modeling approaches for MPs over the past six years. We classified the approaches into three categories as: spatial and temporal distribution, bioaccumulation, and systematic ecological risk assessment. The review analyzed application scenarios, modeling methods, and the advantages and disadvantages of models. The results indicate that the accurate simulation of MPs spatial and temporal distribution requires reasonable parameterization and comprehensive transport considerations. Meanwhile, it is important to focus on coupling process models with other types of models. To enhance risk assessment models, expanding the relevant evaluation indicators is essential.

微塑料污染对水生生态系统构成严重威胁。数值模拟已成为预测水生生态系统中MPs分布、积累和风险评估的有效工具。然而，已发表的工作并没有系统地评估各种建模方法的优缺点。因此，我们在过去六年中对MPs的主要建模方法进行了彻底的审查。我们将这些方法分为时空分布、生物积累和系统生态风险评估三大类。本文分析了模型的应用场景、建模方法和优缺点。结果表明，准确模拟MPs时空分布需要合理的参数化和综合考虑输运因素。同时，关注过程模型与其他类型模型的耦合也很重要。要完善风险评估模型，必须扩大相关评价指标。

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引用次数: 0

Hepatotoxic effects of environmentally relevant concentrations of polystyrene microplastics on senescent Zebrafish (Danio rerio): Patterns of stress response and metabolomic alterations

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2025-02-01 DOI: 10.1016/j.aquatox.2025.107252

Pengfei Xie , Mohammad Mehdi Ommati , Deshan Chen , Weijun Chen , Lei Han , Xinquan Zhao , Hongwei Wang , Shixiao Xu , Ping Sun

The hepatotoxicity of microplastics (MPs) has garnered increasing attention, but their effects on elderly organisms remain inadequately characterized, particularly concerning hepatic stress response patterns in environmental conditions. In this study, a 10-day exposure period of elderly zebrafish to polystyrene microplastics (PS-MPs, 1 µm) was conducted, with exposure concentrations set at 5.6 × 10^–7 µg/L, 5.6 × 10^–4 µg/L, and 5.6 × 10^–1 µg/L. PS-MPs-induced toxicity varied with concentration: superoxide dismutase (SOD), complement 3 (C3), and complement 4 (C4) initially decreased before rising; 8‑hydroxy-2-deoxyguanosine (8-OhdG), interleukin-6 (IL-6), and interleukin-8 (IL-8) increased at high concentrations. Additionally, catalase (CAT) activity and thiobarbituric acid reactive substances (TBARS) contents rose with concentration. The aged zebrafish liver exhibited differentiation driven by responsiveness; low levels cause homeostatic disruption, and high levels induce genotoxicity and immune activation. LC-MS identified twelve crucial metabolites involved in 18 metabolic pathways, including amino acids (L-tyrosine, l-arginine), lipids (phospholipids, 12(S)-leukotriene B4 and triglycerides), and N-acetylneuraminic acid, related to energy, immunity, and neurological health. Overall, elderly zebrafish exhibited clear dose-dependent thresholds and distinct physiological stress responses under varying concentrations of PS-MPs. These findings reveal how PS-MP exposure can affect physiological health and metabolism, offering critical insights into the ecological risks faced by aging organisms.

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