Aquatic Toxicology最新文献_第7页

Are alternatives to polyethylene less toxic than conventional polyethylene? A case study of MP toxicity on Scrobicularia plana using an Integrative Biomarker Response index (IBR-T) 聚乙烯的替代品是否比传统聚乙烯毒性更小？应用综合生物标志物反应指数（IBR-T）研究MP对平面隐索菌的毒性

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-12-09 DOI: 10.1016/j.aquatox.2025.107680

Clémentine Labbé , Isabelle Métais , Hanane Perrein-Ettajani , Mohammed Mouloud , Antoine Le Guernic , Oihana Latchere , Nicolas Manier , Amélie Châtel

Microplastics (MP) are now widely contaminating multiple ecosystems. To mitigate this pollution, the development of plastic alternatives is being promoted. However, scientific data on the absence of toxicity of these alternatives is still lacking. The present study assesses the impact of petroleum-based fragmentable MP, oxo-polyethylene (oxoPE), and biobased biodegradable MP, polylactic acid (PLA), on the bivalve Scrobicularia plana. Clams were exposed for 21 days to environmental concentrations (0.008, 10 and 100 μg L⁻¹) of both PLA and oxoPE MP and impacts were evaluated from individual to molecular levels. The effects of alternative MP were then compared with polyethylene MP ones, resulted from a previous study. An Integrative Biomarker Response - Threshold index (IBR-T) was calculated to assess the differences in toxicity between alternative and conventional plastics. An impact of PLA and oxoPE MP was shown on energy reserves, with a reduction in glycogen concentration in organisms exposed to the highest concentration (100 μg L⁻¹). A decrease in burrowing was also reported in S. plana exposed to 0.008 and 100 µg L⁻¹ of PLA MP. At cellular and molecular levels, catalase (CAT) and glutathione-S-transferases (GST) activities decreased after exposure to PLA MP (10 and 100 μg L⁻¹ respectively) suggesting a disruption of antioxidant and detoxication systems, while no impact was noted on DNA damage, whatever the biodegradable MP. Analysis using IBR-T revealed greater effects of PLA (100 μg L⁻¹) on S. plana physiology compared to the different types of PE MP tested, while oxoPE MP showed limited toxicity. These findings support the importance of assessing the toxic effects of biodegradable and fragmentable MP to evaluate whether they can really be considered as a reliable alternative to conventional plastics.

微塑料（MP）正在广泛污染多种生态系统。为了减轻这种污染，人们正在推动塑料替代品的开发。然而，关于这些替代品没有毒性的科学数据仍然缺乏。本研究评估了石油基可破碎MP，氧聚乙烯（oxoPE）和生物基可生物降解MP，聚乳酸（PLA）对双壳类浮游生物的影响。将蛤蜊暴露于环境浓度（0.008、10和100 μg L−1）的PLA和oxoPE MP中21天，从个体到分子水平评估其影响。然后将替代MP的效果与聚乙烯MP的效果进行比较，这是先前研究的结果。计算了综合生物标志物反应阈值指数（IBR-T）来评估替代塑料和传统塑料之间的毒性差异。PLA和oxoPE MP对能量储备有影响，暴露于最高浓度（100 μg L−1）的生物体中糖原浓度降低。暴露于0.008和100µg L−1 PLA MP的拟南鲷的穴居也有所减少。在细胞和分子水平上，暴露于PLA MP（分别为10和100 μg L−1）后，过氧化氢酶（CAT）和谷胱甘肽- s转移酶（GST）活性下降，表明抗氧化和解毒系统受到破坏，而对DNA损伤没有影响，无论可生物降解的MP是什么。IBR-T分析显示，与不同类型的PE MP相比，PLA （100 μg L−1）对平面葡萄树生理的影响更大，而oxoPE MP的毒性有限。这些发现支持了评估可生物降解和可破碎MP的毒性作用的重要性，以评估它们是否真的可以被认为是传统塑料的可靠替代品。

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引用次数: 0

Direct and indirect ecological impacts of microplastic fibers on host-parasite and host-microbiota interactions 微塑料纤维对宿主-寄生虫和宿主-微生物相互作用的直接和间接生态影响

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-12-28 DOI: 10.1016/j.aquatox.2025.107697

Katarzyna Affek , Nicholas Buss , Gavin Dehnert , Jessica Hite , Andrzej N. Affek , Jessica Hua

Microplastic (MP) pollution poses a growing threat to freshwater ecosystems, yet its effects on ecological interactions, such as host-parasite or host-microbiota dynamics, are poorly understood. Using leopard frog (Lithobates pipiens) tadpoles and their interactions with a common trematode parasite as a model, this study experimentally manipulated MP fiber size (short: ∼0.24 mm; long: ∼1.5 mm) and concentration (10 or 40 μg L⁻¹) to assess effects on tadpole survival, growth, development, behavior, gut microbiota, and parasite susceptibility. High MP concentrations significantly reduced tadpole survival, with long fibers causing greater mortality. Sublethal exposures inhibited development at both concentrations, while 40 μg L⁻¹ also reduced mass and length. Shorter fibers were more frequently ingested, coinciding with altered host behavior and elevated infection intensities, suggesting impaired parasite avoidance. MP exposure caused modest shifts in gut microbiota. In contrast, tadpole gut microbiota was minimally altered by the parasite and MP–parasite treatments. Our findings revealed that MP fiber morphology and concentration interact to shape amphibian health and susceptibility to parasitic infection. These results underscore the importance of incorporating ecological interactions into risk assessments of MP and highlight how environmentally–relevant fiber sizes can disrupt key ecological interactions in freshwater systems.

微塑料污染对淡水生态系统构成越来越大的威胁，但其对生态相互作用（如宿主-寄生虫或宿主-微生物群动力学）的影响却知之甚少。本研究以豹纹蛙（Lithobates pipiens）蝌蚪及其与一种常见吸虫寄生虫的相互作用为模型，实验控制MP纤维的大小（短：~ 0.24 mm；长：~ 1.5 mm）和浓度（10或40 μg L - 1）来评估对蝌蚪生存、生长、发育、行为、肠道微生物群和寄生虫敏感性的影响。高浓度的MP显著降低了蝌蚪的存活率，长纤维蝌蚪的死亡率更高。两种浓度的亚致死暴露都抑制了胎儿的发育，而40 μg L毒血症也减少了胎儿的质量和长度。较短的纤维更频繁地被摄入，与宿主行为改变和感染强度升高相一致，表明对寄生虫的躲避受损。MP暴露引起肠道微生物群的适度变化。相比之下，寄生虫和mp -寄生虫处理对蝌蚪肠道微生物群的影响最小。我们的研究结果表明，MP纤维的形态和浓度相互作用，塑造两栖动物的健康和对寄生虫感染的易感性。这些结果强调了将生态相互作用纳入MP风险评估的重要性，并强调了与环境相关的纤维尺寸如何破坏淡水系统中关键的生态相互作用。

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引用次数: 0

Marine and freshwater mussels as biomonitors for microplastic concentrations: A comparative laboratory study 海洋和淡水贻贝作为微塑料浓度的生物监测仪：一项比较实验室研究

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.aquatox.2025.107659

Adèle Wolinski , Miléna Ferret , Basile Bergeron , Loïc Tettling , Edouard Lavergne , Audrey M. Pruski , Isabelle Calvès , Anne-Leïla Meistertzheim , Franck Lartaud

Microplastics are pervasive in both freshwater and marine waters, posing potential hazards to a wide range of species. Evaluating environmental microplastic pollution is crucial for ecological risk assessment. However, current monitoring methods, such as sampling nets, are inefficient for quantifying small microplastics (< 25 µm) and non-buoyant particles, leading to potential underestimation of pollution levels. Biomonitors, like suspension-feeding organisms, can serve as complementary tools. This study takes a first step in evaluating bivalves as biomonitors by assessing whether microplastic uptake in their tissues correlates with environmental concentrations in both marine and freshwater conditions. Two mussel models, the marine Mytilus galloprovincialis and the freshwater Dreissena spp., were exposed to varying concentrations of microplastics (from 0 to 2000 MPs.L⁻¹) over 48 h. Both marine and freshwater mussels followed a linear model for MP uptake. However, an exponential model appeared more suitable for M. galloprovincialis whereas a Gaussian model better described the uptake pattern in Dreissena spp., suggesting the presence of a threshold in MP capture for the latter species. Microplastics primarily accumulated in the digestive gland compared to other tissues (i.e., byssus, gills, mantle, and others). After 48 h of depuration, marine mussels exhibited a high microplastic depuration rate (from 88 to 97%), while freshwater mussels showed moderate depuration ability (from 0 to 71%). These results support M. galloprovincialis as an effective biomonitor for marine microplastic pollution. In freshwaters, the non-linear accumulation of microplastics by Dreissena spp. limits their suitability for precise pollution assessment, but may help set pollution alert levels based on MP content and sub-lethal effects. This study contributes to addressing the challenge of accurate MP quantification in aquatic environments by highlighting the potential of bioindicators in complementing traditional methods.

微塑料在淡水和海水中普遍存在，对许多物种构成潜在危害。环境微塑料污染评价是生态风险评价的重要内容。然而，目前的监测方法，如采样网，在量化小微塑料（25微米）和非浮力颗粒方面效率低下，导致对污染水平的潜在低估。生物监测仪，如悬浮进食生物，可以作为补充工具。本研究通过评估双壳类动物组织中的微塑料吸收是否与海洋和淡水条件下的环境浓度相关，迈出了评估双壳类动物作为生物监测仪的第一步。两种贻贝模型，海洋贻贝（Mytilus galloprovincialis）和淡水贻贝（Dreissena spp.），暴露于不同浓度的微塑料（从0到2000毫微克）中。L−1)超过48 h。海洋和淡水贻贝的MP摄取都遵循线性模型。然而，指数模型似乎更适合于加洛省m.g logallprovincialis，而高斯模型更好地描述了Dreissena的摄取模式，这表明后者在MP捕获中存在阈值。与其他组织（即足跖、鳃、套膜等）相比，微塑料主要积聚在消化腺中。经过48 h的净化，海洋贻贝的微塑料净化率较高（88% ~ 97%），淡水贻贝的微塑料净化率为中等（0% ~ 71%）。这些结果支持加洛省支原体作为海洋微塑料污染的有效生物监测仪。在淡水中，Dreissena spp.的微塑料的非线性积累限制了它们对精确污染评估的适用性，但可能有助于根据MP含量和亚致死效应设置污染警报级别。本研究通过强调生物指标在补充传统方法方面的潜力，有助于解决水生环境中准确定量MP的挑战。

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引用次数: 0

Sex and physicochemistry modulate the acute toxicity of PAHs in the tropical amphipod model, Parhyale hawaiensis 性别和物理化学调节多环芳烃对热带片足类动物的急性毒性

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2026-01-01 DOI: 10.1016/j.aquatox.2025.107703

Ibrahim Lawan , Gisela de Aragão Umbuzeiro , Alastair R. Lyndon , Theodore B. Henry

Sex-specific physiological differences can modulate the toxicity of contaminants; however, the relationship between these differences and the physicochemistry of toxicants remains understudied. Our objective was to investigate sex-specific differences in the acute toxicity of nine priority polycyclic aromatic hydrocarbons (PAHs) with varying physicochemical properties (logKow: 3.30–6.63) in the tropical marine amphipod Parhyale hawaiensis. Adult males and females were exposed (96 h), toxicity thresholds (LC_x and EC_x) were determined, and Toxic Units (TUs), Hazard Quotients (HQs), and Risk Quotients (RQs) were computed to assess environmental risks. The results revealed a consistent pattern of heightened sensitivity in females for all the tested PAHs. For the most toxic mid-range compounds (logKow 4.4–4.95), females were significantly (p ≤ 0.05) more sensitive than males, with LC₅₀ values of 111.3 µg/L in females and 190.3 µg/L in males for phenanthrene. This heightened sensitivity was particularly evident at lower effect thresholds, where female EC₁₀ values for the most toxic PAHs were approximately two-fold lower than those for males. Toxicity was nonlinear with respect to hydrophobicity, and mid-range PAHs (logKow 4.4–4.95) posed the highest acute toxicity risk. Consequently, the calculated Risk Quotient for phenanthrene in females (RQ = 14.44) was nearly 30 times the Level of Concern (0.5). This study provides foundational toxicity data for a key tropical species, demonstrating that risk assessments that overlook both sex-specific vulnerabilities and the distinct threats of mid-range PAHs may fail to protect critically important tropical marine ecosystems.

性别特异性生理差异可以调节污染物的毒性；然而，这些差异与毒物的物理化学之间的关系仍未得到充分研究。我们的目的是研究具有不同物理化学性质（logKow: 3.30-6.63）的九种优先多环芳烃（PAHs）在热带海洋片足类夏威夷对虾（Parhyale hawaiensis）中的急性毒性的性别差异。对成年男性和女性进行暴露（96 h），确定毒性阈值（LCx和ECx），计算毒性单位（TUs）、危害商数（HQs）和风险商数（RQs），评估环境风险。结果显示，女性对所有测试的多环芳烃都有一致的高度敏感性。对于大多数毒性中等的化合物（logKow 4.4 ~ 4.95），女性对菲的LC50值为111.3µg/L，男性为190.3µg/L，显著高于男性（p≤0.05）。在较低的影响阈值下，这种高度的敏感性尤其明显，其中最有毒的多环芳烃的女性EC10值大约比男性低两倍。毒性与疏水性呈非线性关系，中阶多环芳烃（logKow 4.4-4.95）的急性毒性风险最高。因此，计算得出的女性菲风险商（RQ = 14.44）是关注水平（0.5）的近30倍。这项研究为一个重要的热带物种提供了基本的毒性数据，表明忽视性别特异性脆弱性和中程多环芳烃的独特威胁的风险评估可能无法保护至关重要的热带海洋生态系统。

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引用次数: 0

Crosstalk with the cholinergic pathway may be responsible for chlorpyrifos-induced reproductive toxicity in fish 与胆碱能通路的串扰可能是毒死蜱引起鱼类生殖毒性的原因

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2026-01-09 DOI: 10.1016/j.aquatox.2026.107710

Aoxue Wang , Yujia Yan , Yuyao Jiang , Yanru Guan , Zexin Wen , Shengli Zhou , Yanmei Xu , Haisong Cui , Miqi Jin , Wenjun Gui , Shuying Li

Chlorpyrifos (CPF), a commonly applied organophosphate insecticide, is known to disrupt the endocrine systems of aquatic species. However, further research is required to elucidate the molecular mechanisms involved in the reproductive toxicity of fish. In the present study, zebrafish were exposed to environmentally relevant concentrations of CPF (1, 10, and 50 μg/L) for a 21-day period. Within the concentration range at which chlorpyrifos significantly inhibits the activity of acetylcholinesterase in zebrafish, there is a significant decrease in reproductive capacity of 31.65 %. The RNA-seq analysis has revealed that processes such as transporter activity, reproduction, and reproductive function are affected. Elevated FSH and LH levels in CPF-exposed females were observed at concentrations of 10 μg/L and 50 μg/L. Furthermore, the CPF treatment resulted in the upregulation of esr2b, hsd3b1, fshr, gnrh2, vtg1, and vtg2, while cyp19a1a was found to be downregulated. Co-exposure to cetrorelix acetate, a potent GnRH receptor antagonist, has been demonstrated to normalize gene expression and restore E₂ levels. These results suggest that CPF-induced reproductive toxicity involves crosstalk between cholinergic signaling and the HPG axis. These findings underscore the complex toxicity and ecological risks associated with CPF.

毒死蜱（CPF）是一种常用的有机磷杀虫剂，已知会破坏水生物种的内分泌系统。然而，还需要进一步的研究来阐明鱼类生殖毒性的分子机制。在本研究中，斑马鱼暴露于环境相关浓度的CPF（1、10和50 μg/L）中21天。在毒死蜱显著抑制斑马鱼乙酰胆碱酯酶活性的浓度范围内，斑马鱼的繁殖能力显著下降31.65%。RNA-seq分析揭示了转运蛋白活性、繁殖和生殖功能等过程受到影响。cpf暴露的雌性在浓度为10 μg/L和50 μg/L时FSH和LH水平升高。此外，CPF处理导致esr2b、hsd3b1、fshr、gnrh2、vtg1和vtg2上调，而cyp19a1a下调。共同暴露于醋酸cetrorelix（一种有效的GnRH受体拮抗剂）已被证明可以使基因表达正常化并恢复E2水平。这些结果表明cpf诱导的生殖毒性涉及胆碱能信号和HPG轴之间的串扰。这些发现强调了CPF相关的复杂毒性和生态风险。

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引用次数: 0

Chronic paternal or maternal exposure to florfenicol causes reproductive and developmental toxicity in marine medaka (Oryzias melastigma) 父亲或母亲接触氟苯尼考会导致海洋medaka （Oryzias melastigma）的生殖和发育毒性。

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-12-24 DOI: 10.1016/j.aquatox.2025.107692

Xingying Guo, Tan-Duc Nguyen, Qingshi Chen, Xiaomin Wu, Wenhua Liu, Zhen Wang

New pollutants impair the reproduction and development of offspring in marine fish after parental exposure. While florfenicol has been frequently detected in the environment and organisms, limited information is available on its effects on the endocrine system of marine fishes and their developmental defects in offspring. In this study, six-month-old marine medaka (Oryzias melastigma) were exposed to florfenicol at 0.1 and 89 μg/L (measured) for 28 days. A cross-mating experimental design was employed to generate offspring embryos from various cross-mates by combining and mating control and exposed O. melastigma (male or female), thereby differentiating maternal and paternal influences. The results showed that either paternal or maternal exposure to florfenicol could affect the embryonic development of offspring. Additionally, parental exposure to florfenicol resulted in lower hatching rates and increased mortality in F1 embryos, even when cultured in clean seawater. Furthermore, the embryos of each cross-breeding group displayed distinct expressions of apoptosis-related genes, indicating that florfenicol can induce varying degrees of apoptosis in embryos. Altered expressions of genes related to endocrine disruption in the gonads were also identified, and morphological changes were observed in ovarian and testicular tissue sections of adult fish. The florfenicol-treated group showed a decrease in mature oocytes in the ovaries and an increase in interstitial tissue in the tests. In general, chronic exposure to florfenicol caused energy metabolism disorders, altered the expression of endocrine disruption related genes, damaged gonadal tissues, and led to reproductive dysfunction in O. melastigma, thereby impairing the production and development of their offspring. Overall, the key findings of this study demonstrated that extended exposure of paternal or maternal exposure to florfenicol significantly induced reproductive toxicity in adult medaka, leading to developmental toxicity in their offspring.

新污染物在亲代接触后对海鱼后代的繁殖和发育造成损害。虽然氟苯尼考经常在环境和生物体中被发现，但关于其对海洋鱼类内分泌系统的影响及其后代发育缺陷的资料有限。本研究以6个月大的海鳉鱼（Oryzias melastigma）为研究对象，分别暴露于0.1和89 μg/L（测量值）的氟苯尼考28天。采用交叉交配实验设计，通过组合、交配控制和暴露（雄性或雌性），从不同的杂交伴侣产生后代胚胎，从而区分母系和父系的影响。结果表明，父亲或母亲接触氟苯尼考均可影响后代的胚胎发育。此外，父母接触氟苯尼考导致F1胚胎的孵化率降低和死亡率增加，即使在清洁海水中培养也是如此。此外，各杂交组胚胎的凋亡相关基因表达不同，表明氟苯尼考可诱导不同程度的胚胎凋亡。性腺中与内分泌干扰相关的基因表达也发生了改变，在成年鱼的卵巢和睾丸组织切片中观察到形态学变化。氟苯尼考组显示卵巢成熟卵母细胞减少，间质组织增加。总的来说，长期暴露于氟苯尼考可引起能量代谢紊乱，改变内分泌干扰相关基因的表达，损伤性腺组织，导致褐斑O.生殖功能障碍，从而影响其后代的生产和发育。总体而言，本研究的主要发现表明，父亲或母亲长时间暴露于氟苯尼考可显著诱导成年medaka的生殖毒性，从而导致其后代的发育毒性。

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引用次数: 0

Aroclor 1254 impairs visual and neurosensory signaling pathways independent of the aryl hydrocarbon receptor in larval zebrafish Aroclor 1254对斑马鱼幼虫的视觉和神经感觉信号通路的影响不依赖于芳烃受体

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-12-25 DOI: 10.1016/j.aquatox.2025.107695

Jason T. Magnuson , Corey S. Green , Jeffrey M. Morris , Rachel R. Leads , Claire R. Lay , Michel Gielazyn , Lisa Rosman , Aaron P. Roberts , Daniel Schlenk

Aroclor 1254 is a mixture of polychlorinated biphenyl (PCB) congeners that are present in aquatic systems originating from coolants, solvents, plasticizers, and shipbreaking. Aroclor 1254 can induce an eye tremor response in early life stage zebrafish (Danio rerio) following exposure to between 22.7 and 4140 µg/L Aroclor 1254 at 102 h post fertilization (hpf), as shown in our recent study. However, the underlying mechanism that induces this response, either acting through the aryl hydrocarbon receptor (AhR) or non-AhR pathways, is not well characterized. As such, transcriptomics, morphology, and targeted behavioral functions were assessed using previously exposed larvae. Transcriptomic profiling was conducted in 102 hpf larvae to elucidate what may be driving this tremor response using in silico bioinformatic software. Subsequent eye tremor responses, a visually mediated behavioral function assay, and eye morphology were assessed in 7 day post fertilization (dpf) larvae after embryonic treatment. Parkinson’s signaling pathway, opioid signaling pathway, and the negative regulation of general cell signaling and communication were the top enriched dose-dependent pathways predicted. Eye diameters were significantly decreased in 7 dpf larvae exposed to 173 µg/L Aroclor 1254, whereas the number of eye saccades, assessed with an optokinetic response assay, and eye tremor response behavior were increased following exposure to a concentration of ≥ 173 µg/L Aroclor 1254. This suggests that Aroclor 1254 acts through a cross-talk of visual and neuronal-based mechanisms, and that non-AhR pathways may be more important than AhR pathways in inducing visual effects, which may influence survivorship and recruitment in early life stage wild fish.

Aroclor 1254是多氯联苯（PCB）同系物的混合物，存在于水生系统中，源自冷却剂、溶剂、增塑剂和拆船。我们最近的研究表明，在受精后102小时，暴露于22.7至4140µg/L的Aroclor 1254中，Aroclor 1254可以诱导早期斑马鱼（Danio rerio）的眼震颤反应。然而，诱导这种反应的潜在机制，无论是通过芳烃受体（AhR）还是非AhR途径，都没有很好地表征。因此，使用先前暴露的幼虫评估转录组学，形态学和目标行为功能。利用硅生物信息学软件对102只hpf幼虫进行了转录组学分析，以阐明可能驱动这种震颤反应的原因。在胚胎处理后的受精后7天（dpf）幼虫中，对随后的眼震颤反应、视觉介导的行为功能测定和眼睛形态进行了评估。帕金森信号通路、阿片信号通路和一般细胞信号和通讯的负调控是预测的最富集的剂量依赖性通路。暴露于173µg/L Aroclor 1254的7只dpf幼虫的眼直径显著减小，而暴露于浓度≥173µg/L Aroclor 1254后，用光动力学反应试验评估的眼跳次数和眼震颤反应行为增加。这表明Aroclor 1254通过视觉和神经元机制的交叉作用起作用，非AhR通路在诱导视觉效果方面可能比AhR通路更重要，这可能影响野生鱼类生命早期的生存和招募。

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引用次数: 0

Size-dependent and tissue specific accumulation of polystyrene microplastics and nanoplastics in zebrafish 聚苯乙烯微塑料和纳米塑料在斑马鱼体内的大小依赖性和组织特异性积累

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-12-05 DOI: 10.1016/j.aquatox.2025.107678

Min Su , Dangen Gu , Le Liang , Zhendong Zhou , Chenchen Zhu , Jiaoyang Qi , Pu Wu , Tian Xu , Zhongguan Jiang

As emerging pollutants, micro-nanoplastics (MNPs), have been widely detected in aquatic ecosystems. When engaging with fish species, MNPs can be initially accumulated in fish gills and intestinal tract, followed by subsequent transportation to other tissues and organs through the circulatory system. However, the tissue-specific accumulation of MNPs in relation to size differences remains uncertain. In this study, continuous exposure experiments with MNPs of different particle sizes were conducted to evaluate tissue-specific accumulation and to examine associated biochemical responses. Generally, fish intestine and gills accumulated MNPs of all size, whereas fish muscle and brain only accumulated nano-sized MNPs. Specifically, fish muscle and brain showed significantly higher MNPs enrichment of 25 nm (vs. 250 nm), since they can easily pass through the intercellular spaces or be endocytosed within cells. In terms of time-dependent accumulations, fish intestines and gills exhibited rapid initial uptake followed by fluctuating variations of MNPs as exposing lasted, since these organs possess both a high capacity for MNP accessibility and elimination. However, fish liver and brain showed a monotonic increase in MNPs accumulation with continuous exposure, which can be ascribed to the difficulty in draining the metabolic waste of these organs. When examining toxic effects, both AChE and CYP450 enzyme activities in all exposure groups were significantly higher than the control group, indicating that MNPs triggered neurotoxicity and metabolic detoxification. Our study highlights considering size and tissue-specific accumulations of MNPs when planning MNPs control for fish health and fishery products safety.

微纳米塑料（MNPs）作为一种新兴的污染物，在水生生态系统中被广泛发现。与鱼类接触时，MNPs最初可在鱼鳃和肠道中积累，随后通过循环系统运输到其他组织和器官。然而，MNPs的组织特异性积累与大小差异的关系仍然不确定。在这项研究中，不同粒径的MNPs进行了连续暴露实验，以评估组织特异性积累并检查相关的生化反应。一般来说，鱼的肠道和鳃会积累各种大小的MNPs，而鱼的肌肉和大脑只会积累纳米大小的MNPs。具体来说，鱼类肌肉和大脑的MNPs富集程度明显高于25 nm (250 nm)，因为它们可以很容易地通过细胞间隙或在细胞内被内吞。就时间依赖性积累而言，鱼的肠道和鳃表现出快速的初始吸收，随后随着暴露时间的持续，MNP的波动变化，因为这些器官具有高的MNP可及性和消除能力。然而，随着持续暴露，鱼肝脏和大脑的MNPs积累单调增加，这可能归因于这些器官的代谢废物难以排出。在检测毒性作用时，所有暴露组的AChE和CYP450酶活性均显著高于对照组，表明MNPs触发了神经毒性和代谢解毒。我们的研究强调，在规划MNPs控制以保证鱼类健康和渔业产品安全时，应考虑MNPs的大小和组织特异性积累。

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引用次数: 0

Micro/nanoplastic-induced stress in microalgae: Latest laboratory evidence and knowledge gaps 微藻中微/纳米塑性诱导的应力：最新的实验室证据和知识空白

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI: 10.1016/j.aquatox.2025.107677

Amina Antonacci , Vincenzo Vedi , Sara Colella , Alessia Di Fraia , Manuela Rossi , Gabriella Fiorentino , Viviana Scognamiglio

Pollution by micro- and nanoplastics (MNPs) is a major concern today, with direct consequences for human health and the environment. Microalgae, among the main primary producers in aquatic ecosystems, suffer from MNPs contamination due to the worrying amount of plastic waste and its persistence in the environment. This problem has mobilized international organizations and raised awareness among the scientific community for the identification of effective solutions. Policies aimed at reducing plastic products, waste management, and recycling are attempting to limit this problem; however, plastic pollution appears to be irreversible. Therefore, a critical analysis of the effects of MNPs on various microorganisms (e.g., microalgae) is urgently needed. Therefore, the objective of this review was to identify the impact of micro- and nanoplastics on microalgal populations, based on the currently available literature. Particular attention was paid to available laboratory studies on MNPs effects on microalgae physiology - as growth rate, pigment content, photosynthetic activity, oxidative stress - and morphology, with the aim of providing an update on the state of the art.

微塑料和纳米塑料造成的污染是当今的一个主要问题，对人类健康和环境产生直接影响。微藻是水生生态系统中主要的初级生产者之一，由于令人担忧的塑料废物数量及其在环境中的持久性，微藻受到MNPs污染。这一问题调动了国际组织，提高了科学界的认识，以便找出有效的解决办法。旨在减少塑料制品、废物管理和回收的政策正试图限制这一问题；然而，塑料污染似乎是不可逆转的。因此，迫切需要对MNPs对各种微生物（如微藻）的影响进行批判性分析。因此，本综述的目的是在现有文献的基础上确定微塑料和纳米塑料对微藻种群的影响。特别注意了关于MNPs对微藻生理（如生长速度、色素含量、光合活性、氧化应激）和形态的影响的现有实验室研究，目的是提供最新的技术状况。

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引用次数: 0

Unveiling the hidden impacts: A comprehensive review of microplastic effects on marine bivalves 揭示隐藏的影响：微塑料对海洋双壳类动物影响的综合综述

IF 4.3 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2026-02-01 Epub Date: 2025-11-24 DOI: 10.1016/j.aquatox.2025.107657

Zhaowen Chen , Sijie Fan , Wenbo Guo , Menghong Hu , Jae-Seong Lee , Youji Wang

Microplastics (MPs) pollution has become a global environmental issue, posing significant potential risks to marine ecosystems, especially bivalve mollusks. Studies have shown that bivalves are at increased risk of ingesting and accumulating MPs due to their filter-feeding habits, which leads to a series of physiological and ecological consequences. This review highlights the current knowledge gap in the study of MP bioaccumulation in bivalves: The effect of biofilm on MPs’ bioaccumulation and selective excretion. The ingestion of MPs can induce oxidative stress and cell damage, impair normal physiological functions, and inhibit bivalve growth, which in turn affects their immune response and overall health. In addition to the effects on individual bivalves, this review innovatively analyzes the adverse ecological consequences of MPs on aquatic ecosystems from the perspectives of nutrient cycling and energy flow. Based on the filter-feeding characteristics of bivalves, we also discuss their potential in mitigating MPs pollution. This review not only summarized the findings in microplastic ecotoxicology research on marine bivalves in recent years, but also provided the perspectives are significant for exploring effective strategies to reduce MPs pollution, protect marine ecosystems, and safeguard human health.

微塑料污染已成为一个全球性的环境问题，对海洋生态系统，特别是双壳类软体动物构成了重大的潜在风险。研究表明，由于双壳类动物的滤食性，它们摄入和积累MPs的风险增加，从而导致一系列生理和生态后果。本文综述了目前在双壳类动物中MPs生物积累研究中的知识空白：生物膜对MPs生物积累和选择性排泄的影响。摄入MPs可诱导氧化应激和细胞损伤，损害正常生理功能，抑制双壳类动物生长，进而影响其免疫反应和整体健康。除了对双壳类动物个体的影响外，本文还创新性地从营养循环和能量流的角度分析了MPs对水生生态系统的不利生态后果。基于双壳类的滤食特性，我们还讨论了它们在减轻MPs污染方面的潜力。本文综述了近年来海洋双壳类动物微塑料生态毒理学研究的最新进展，并为探索减少微塑料污染、保护海洋生态系统、保障人类健康的有效策略提供了新的视角。

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引用次数: 0