Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2024.107213
Rasha M. Reda , Eman M. Zaki , Ahmed A.A. Aioub , Mohamed M.M. Metwally , Fatma Mahsoub
This study aims to examine the restorative impact of corn cob biochar (CCB) on pendimethalin (PMD)-induced toxicity in Oreochromis niloticus. Fish were divided into four groups: the first control group without treatment, the second group (CCB) exposed to 10 g CCB/L, the third group (PDM) exposed to 0.355 mg PDM/L, and the fourth group (PDM+ CCB) receiving both 0.355 mg PDM/L and 10 g CCB/L for 30 days. PDM exposure resulted in behavioral alterations, low survival rate (73.33 %), hematological and biochemical impairments, increased oxidative stress, suppressed immunity, and histopathological damage in gill, liver, and brain tissues. Co-treatment with CCB significantly alleviated these effects, as evidenced by improved survival rate (88.88 %), hematological, biochemical, and antioxidant-immune parameters and reduced histopathological alterations. In conclusion, CCB demonstrated a promising potential to mitigate PDM-induced toxicity in O. niloticus by enhancing physiological, biochemical, and histological resilience.
本研究旨在研究玉米芯生物炭（CCB）对二甲甲烷（PMD）诱导的nilochromis毒性的恢复作用。鱼被分为四组：第一组未处理，第二组（CCB）暴露于10 g CCB/L，第三组（PDM）暴露于0.355 mg PDM/L，第四组（PDM+ CCB）同时接受0.355 mg PDM/L和10 g CCB/L，持续30天。PDM暴露导致行为改变、低存活率（73.33%）、血液学和生化损伤、氧化应激增加、免疫抑制以及鳃、肝和脑组织的组织病理学损伤。与CCB联合治疗显著缓解了这些影响，证明了生存率（88.88%）、血液学、生化和抗氧化免疫参数的提高以及组织病理学改变的减少。综上所述，CCB通过增强niloticus的生理、生化和组织学恢复力，显示出减轻pdm诱导的毒性的潜力。
{"title":"The potential effects of corn cob biochar on mitigating pendimethalin-induced toxicity in Nile tilapia (Oreochromis niloticus): Effects on hematological, biochemical, antioxidant-immune parameters, and histopathological alterations","authors":"Rasha M. Reda , Eman M. Zaki , Ahmed A.A. Aioub , Mohamed M.M. Metwally , Fatma Mahsoub","doi":"10.1016/j.aquatox.2024.107213","DOIUrl":"10.1016/j.aquatox.2024.107213","url":null,"abstract":"<div><div>This study aims to examine the restorative impact of corn cob biochar (CCB) on pendimethalin (PMD)-induced toxicity in <em>Oreochromis niloticus</em>. Fish were divided into four groups: the first control group without treatment, the second group (CCB) exposed to 10 g CCB/L, the third group (PDM) exposed to 0.355 mg PDM/L, and the fourth group (PDM+ CCB) receiving both 0.355 mg PDM/L and 10 g CCB/L for 30 days. PDM exposure resulted in behavioral alterations, low survival rate (73.33 %), hematological and biochemical impairments, increased oxidative stress, suppressed immunity, and histopathological damage in gill, liver, and brain tissues. Co-treatment with CCB significantly alleviated these effects, as evidenced by improved survival rate (88.88 %), hematological, biochemical, and antioxidant-immune parameters and reduced histopathological alterations. In conclusion, CCB demonstrated a promising potential to mitigate PDM-induced toxicity in <em>O. niloticus</em> by enhancing physiological, biochemical, and histological resilience.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107213"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2024.107216
Souvik Pore , Alexia Pelloux , Anders Bergqvist , Mainak Chatterjee , Kunal Roy
Early life stage (ELS) toxicity testing in fish is a crucial test procedure used to evaluate the long-term effects of a wide range of chemicals, including pesticides, industrial chemicals, pharmaceuticals, and food additives. This test is particularly important for screening and prioritizing thousands of chemicals under the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation. In silico methods can be used to estimate the toxicity of a chemical when no experimental data is available and to reduce the cost, time, and resources involved in the experimentation process. In the present study, we developed predictive Quantitative Structure-Activity Relationship (QSAR) models to assess chronic effects of chemicals on ELS in fish. Toxicity data for ELS in fish was collected from two different sources, i.e. J-CHECK and eChemPortal, which contain robust study summaries of experimental studies performed according to OECD Test Guideline 210. The collected data included two types of endpoints – the No Observed Effect Concentration (NOEC) and the Lowest Observed Effect Concentration (LOEC), which were utilized to develop the QSAR models. Six different partial least squares (PLS) models with various descriptor combinations were created for both endpoints. These models were then employed for intelligent consensus-based prediction to enhance predictability for unknown chemicals. Among these models, the consensus model – 3 (Q2F1 = 0.71, Q2F2 = 0.71) and individual model – 3 (Q2F1 = 0.80, Q2F2 = 0.79) exhibited most promising results for both the NOEC and LOEC endpoints. Furthermore, these models were validated experimentally using experimental data from nine different industrial chemicals provided by Global Product Compliance (Europe) AB. Lastly, the models were used to screen and prioritize chemicals obtained from the Pesticide Properties (PPDB) and DrugBank databases.
{"title":"Intelligent consensus-based predictions of early life stage toxicity in fish tested in compliance with OECD Test Guideline 210","authors":"Souvik Pore , Alexia Pelloux , Anders Bergqvist , Mainak Chatterjee , Kunal Roy","doi":"10.1016/j.aquatox.2024.107216","DOIUrl":"10.1016/j.aquatox.2024.107216","url":null,"abstract":"<div><div>Early life stage (ELS) toxicity testing in fish is a crucial test procedure used to evaluate the long-term effects of a wide range of chemicals, including pesticides, industrial chemicals, pharmaceuticals, and food additives. This test is particularly important for screening and prioritizing thousands of chemicals under the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation. In silico methods can be used to estimate the toxicity of a chemical when no experimental data is available and to reduce the cost, time, and resources involved in the experimentation process. In the present study, we developed predictive Quantitative Structure-Activity Relationship (QSAR) models to assess chronic effects of chemicals on ELS in fish. Toxicity data for ELS in fish was collected from two different sources, i.e. J-CHECK and eChemPortal, which contain robust study summaries of experimental studies performed according to OECD Test Guideline 210. The collected data included two types of endpoints – the No Observed Effect Concentration (NOEC) and the Lowest Observed Effect Concentration (LOEC), which were utilized to develop the QSAR models. Six different partial least squares (PLS) models with various descriptor combinations were created for both endpoints. These models were then employed for intelligent consensus-based prediction to enhance predictability for unknown chemicals. Among these models, the consensus model – 3 (Q<sup>2</sup><sub>F1</sub> = 0.71, Q<sup>2</sup><sub>F2</sub> = 0.71) and individual model – 3 (Q<sup>2</sup><sub>F1</sub> = 0.80, Q<sup>2</sup><sub>F2</sub> = 0.79) exhibited most promising results for both the NOEC and LOEC endpoints. Furthermore, these models were validated experimentally using experimental data from nine different industrial chemicals provided by Global Product Compliance (Europe) AB. Lastly, the models were used to screen and prioritize chemicals obtained from the Pesticide Properties (PPDB) and DrugBank databases.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107216"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2024.107230
Chaoqiong Wu , Guanghua Mao , Xiang Ji , Yao Chen , Xin Geng , Emmanuel Sunday Okeke , Yangyang Ding , Liuqing Yang , Xiangyang Wu , Weiwei Feng
Monoethylhexyl phthalate (MEHP) is the primary metabolite of di(2-ethylhexyl) phthalate (DEHP), the most prevalent phthalate plasticiser globally. It has been demonstrated that MEHP exerts more potent toxic effects than DEHP. Nevertheless, the full extent of the toxicity of MEHP to neurodevelopmental organisms remains unclear. Accordingly, the present study was designed to investigate the neurodevelopmental toxicity of MEHP exposure and the underlying molecular mechanisms. Zebrafish juveniles were exposed to different concentrations of MEHP (7.42, 14.84, 29.68 and 74.2 μg/L) for a period of four weeks. Immunohistological evidence indicated that MEHP exposure resulted in oxidative stress and apoptosis in the developing zebrafish brain. Subsequently, the neurobehaviour of zebrafish larvae was evaluated, and it was determined that MEHP significantly disrupted their locomotor capacity, motor vigor, and social conduct. Furthermore, HE staining revealed damage to brain neurons, which may be linked to impaired synthesis and conduction of inter-synaptic neurotransmitters. Transcriptomic analyses indicated that MEHP may affect the expression levels of genes in the P53 signalling pathway and signalling pathways related to the development of the nervous system. This results in impaired functions, including nerve conduction and neuronal development. Additionally, it induces oxidative stress, which leads to significant brain cell apoptosis and, ultimately, neurotoxicity in developing zebrafish.
{"title":"Neurodevelopmental toxicity and mechanism of action of monoethylhexyl phthalate (MEHP) in the developing zebrafish (Danio rerio)","authors":"Chaoqiong Wu , Guanghua Mao , Xiang Ji , Yao Chen , Xin Geng , Emmanuel Sunday Okeke , Yangyang Ding , Liuqing Yang , Xiangyang Wu , Weiwei Feng","doi":"10.1016/j.aquatox.2024.107230","DOIUrl":"10.1016/j.aquatox.2024.107230","url":null,"abstract":"<div><div>Monoethylhexyl phthalate (MEHP) is the primary metabolite of di(2-ethylhexyl) phthalate (DEHP), the most prevalent phthalate plasticiser globally. It has been demonstrated that MEHP exerts more potent toxic effects than DEHP. Nevertheless, the full extent of the toxicity of MEHP to neurodevelopmental organisms remains unclear. Accordingly, the present study was designed to investigate the neurodevelopmental toxicity of MEHP exposure and the underlying molecular mechanisms. Zebrafish juveniles were exposed to different concentrations of MEHP (7.42, 14.84, 29.68 and 74.2 μg/L) for a period of four weeks. Immunohistological evidence indicated that MEHP exposure resulted in oxidative stress and apoptosis in the developing zebrafish brain. Subsequently, the neurobehaviour of zebrafish larvae was evaluated, and it was determined that MEHP significantly disrupted their locomotor capacity, motor vigor, and social conduct. Furthermore, HE staining revealed damage to brain neurons, which may be linked to impaired synthesis and conduction of inter-synaptic neurotransmitters. Transcriptomic analyses indicated that MEHP may affect the expression levels of genes in the P53 signalling pathway and signalling pathways related to the development of the nervous system. This results in impaired functions, including nerve conduction and neuronal development. Additionally, it induces oxidative stress, which leads to significant brain cell apoptosis and, ultimately, neurotoxicity in developing zebrafish.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107230"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2024.107232
Eram Rashid , Syed Makhdoom Hussain , Shafaqat Ali , Muhammad Munir , Abdul Ghafoor , Ebru Yilmaz , Mohammed Ali Alshehri , Danish Riaz , Adan Naeem , Eman Naeem
The presence of microplastics (MPs) in aquatic ecosystem has become a pressing global concern. MPs pose a significant threat to aquatic ecosystems, with devastating consequences for both aquatic life and human health. Notably, freshwater ecosystems are particularly vulnerable to MPs pollution. MPs, characterized by their small size (< 5 mm), have emerged as a ubiquitous environmental pollutant. They exhibit diverse characteristics, including varying sizes, forms, polymer types, and colors. Two distinct categories of MPs exist: primary and secondary. Primary MPs are incorporated into industrial hard materials, cosmetics, and hand cleaners, whereas secondary MPs result from the breakdown of larger plastic products in both terrestrial and marine environments. They enter the environment through various sources, such as household products, clothing, industrial activities, sewage waste and plastic degradation. Aquatic organisms ingest these contaminants, facilitating the transfer of MPs into the food chain and potentially causing severe health problems. This review delves into the bioaccumulation of MPs in fish, highlighting the eco-toxicological, neurological and immunological effects. This review provides an in-depth analysis of innovative solutions for MPs removal and reduction. Finally, we delineate evidence-based strategies to mitigate impacts of MPs, offering valuable insights to inform policy formulations and accelerate the development of sustainable plastic technologies.
{"title":"Impacts of microplastic accumulation in aquatic environment: Physiological, eco-toxicological, immunological, and neurotoxic effects","authors":"Eram Rashid , Syed Makhdoom Hussain , Shafaqat Ali , Muhammad Munir , Abdul Ghafoor , Ebru Yilmaz , Mohammed Ali Alshehri , Danish Riaz , Adan Naeem , Eman Naeem","doi":"10.1016/j.aquatox.2024.107232","DOIUrl":"10.1016/j.aquatox.2024.107232","url":null,"abstract":"<div><div>The presence of microplastics (MPs) in aquatic ecosystem has become a pressing global concern. MPs pose a significant threat to aquatic ecosystems, with devastating consequences for both aquatic life and human health. Notably, freshwater ecosystems are particularly vulnerable to MPs pollution. MPs, characterized by their small size (< 5 mm), have emerged as a ubiquitous environmental pollutant. They exhibit diverse characteristics, including varying sizes, forms, polymer types, and colors. Two distinct categories of MPs exist: primary and secondary. Primary MPs are incorporated into industrial hard materials, cosmetics, and hand cleaners, whereas secondary MPs result from the breakdown of larger plastic products in both terrestrial and marine environments. They enter the environment through various sources, such as household products, clothing, industrial activities, sewage waste and plastic degradation. Aquatic organisms ingest these contaminants, facilitating the transfer of MPs into the food chain and potentially causing severe health problems. This review delves into the bioaccumulation of MPs in fish, highlighting the eco-toxicological, neurological and immunological effects. This review provides an in-depth analysis of innovative solutions for MPs removal and reduction. Finally, we delineate evidence-based strategies to mitigate impacts of MPs, offering valuable insights to inform policy formulations and accelerate the development of sustainable plastic technologies.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107232"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2025.107244
Ye Lin , Xin Yang , Mingxuan Zhang , Jinyan Cheng , Hai Lin , Qi Zhao
As compound concentrations in aquatic environments increase, the habitat degradation of aquatic organisms underscores the growing importance of studying the impact of chemicals on diverse aquatic populations. Understanding the potential impacts of different chemical substances on different species is a necessary requirement for protecting the environment and ensuring sustainable human development. In this regard, deep learning methods offer significant advantages over traditional experimental approaches in terms of cost, accuracy, and generalization ability. This research introduces CLSSATP, an efficient contrastive self-supervised learning deep neural network prediction model for organic toxicity. The model integrates two modules, a self-supervised learning module using molecular fingerprints for representation, and a contrastive learning module utilizing molecular graphs. Through dual-perspective learning, the model gains clear insights into the structural and property relationships of molecules. The experiment results indicate that our model outperforms comparative methods, demonstrating the effectiveness of our proposed architecture. Moreover, ablation experiments show that the self-supervised module and contrastive learning module respectively provide average performance improvements of 9.43 % and 10.98 % to CLSSATP. Furthermore, by visualizing the representations of our model, we observe that it correctly identifies the substructures that determine the molecular properties, granting itself with interpretability. In conclusion, CLSSATP offers a novel and effective perspective for future research in aquatic toxicity assessment. All of codes and datasets are freely available online at https://github.com/zhaoqi106/CLSSATP.
{"title":"CLSSATP: Contrastive learning and self-supervised learning model for aquatic toxicity prediction","authors":"Ye Lin , Xin Yang , Mingxuan Zhang , Jinyan Cheng , Hai Lin , Qi Zhao","doi":"10.1016/j.aquatox.2025.107244","DOIUrl":"10.1016/j.aquatox.2025.107244","url":null,"abstract":"<div><div>As compound concentrations in aquatic environments increase, the habitat degradation of aquatic organisms underscores the growing importance of studying the impact of chemicals on diverse aquatic populations. Understanding the potential impacts of different chemical substances on different species is a necessary requirement for protecting the environment and ensuring sustainable human development. In this regard, deep learning methods offer significant advantages over traditional experimental approaches in terms of cost, accuracy, and generalization ability. This research introduces CLSSATP, an efficient contrastive self-supervised learning deep neural network prediction model for organic toxicity. The model integrates two modules, a self-supervised learning module using molecular fingerprints for representation, and a contrastive learning module utilizing molecular graphs. Through dual-perspective learning, the model gains clear insights into the structural and property relationships of molecules. The experiment results indicate that our model outperforms comparative methods, demonstrating the effectiveness of our proposed architecture. Moreover, ablation experiments show that the self-supervised module and contrastive learning module respectively provide average performance improvements of 9.43 % and 10.98 % to CLSSATP. Furthermore, by visualizing the representations of our model, we observe that it correctly identifies the substructures that determine the molecular properties, granting itself with interpretability. In conclusion, CLSSATP offers a novel and effective perspective for future research in aquatic toxicity assessment. All of codes and datasets are freely available online at <span><span>https://github.co</span><svg><path></path></svg></span><span><span><em>m/z</em></span><svg><path></path></svg></span><span><span>haoqi106/CLSSATP</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107244"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2025.107246
Carolina Arantes de Moraes , Fagner Neves Oliveira , Gabriel Qualhato , Pedro Vale de Azevedo Brito , Karina Simões , Thiago Lopes Rocha , Raquel Fernanda Salla , Lucélia Gonçalves Vieira
The rising production and improper disposal of titanium dioxide nanoparticles (TiO2 NPs) into aquatic systems present considerable environmental challenges, especially when these particles interact with other contaminants such as cadmium (Cd). Thus, the current study aimed to evaluate the potential toxic effects on the gills, chondrocranium, body growth, and mortality of Aquarana catesbeiana tadpoles. The tadpoles were exposed to environmentally relevant concentrations of TiO2 NPs (10 µg L-1), and CdCl2 (10 µg L-1), both individually and in combination, for 30 days (chronic exposure), along with a control group. Our results indicate that the co-exposure to TiO2 NPs and Cd induced a higher mortality rate. In the gills, TiO2 NPs led to epithelial simplification, while Cd exposure resulted in stratified epithelium formation. Additionally, there were notable changes in the index of degenerative alterations for the co-exposed group and the overall organ index for the groups exposed to Cd and the mixture. The viscerocranium showed significant malformations in the ceratobranchials and reticular processes, indicating the mixture's toxicological potential during the skeletal system's development. Morphometric analysis also revealed reduced body length and abnormal body ratios in tadpoles from the co-exposure group. In conclusion, TiO2 NPs and Cd, both alone and in combination, exhibit toxicological effects in A. catesbeiana tadpoles, indicating a potential ecological risk associated with releasing these contaminants into aquatic environments.
{"title":"Single and combined chronic toxicity of cadmium and titanium dioxide nanoparticles in Aquarana catesbeiana (Anura: Ranidae) tadpoles","authors":"Carolina Arantes de Moraes , Fagner Neves Oliveira , Gabriel Qualhato , Pedro Vale de Azevedo Brito , Karina Simões , Thiago Lopes Rocha , Raquel Fernanda Salla , Lucélia Gonçalves Vieira","doi":"10.1016/j.aquatox.2025.107246","DOIUrl":"10.1016/j.aquatox.2025.107246","url":null,"abstract":"<div><div>The rising production and improper disposal of titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) into aquatic systems present considerable environmental challenges, especially when these particles interact with other contaminants such as cadmium (Cd). Thus, the current study aimed to evaluate the potential toxic effects on the gills, chondrocranium, body growth, and mortality of <em>Aquarana catesbeiana</em> tadpoles. The tadpoles were exposed to environmentally relevant concentrations of TiO<sub>2</sub> NPs (10 µg L<sup>-1</sup>), and CdCl<sub>2</sub> (10 µg L<sup>-1</sup>), both individually and in combination, for 30 days (chronic exposure), along with a control group. Our results indicate that the co-exposure to TiO<sub>2</sub> NPs and Cd induced a higher mortality rate. In the gills, TiO<sub>2</sub> NPs led to epithelial simplification, while Cd exposure resulted in stratified epithelium formation. Additionally, there were notable changes in the index of degenerative alterations for the co-exposed group and the overall organ index for the groups exposed to Cd and the mixture. The viscerocranium showed significant malformations in the ceratobranchials and reticular processes, indicating the mixture's toxicological potential during the skeletal system's development. Morphometric analysis also revealed reduced body length and abnormal body ratios in tadpoles from the co-exposure group. In conclusion, TiO<sub>2</sub> NPs and Cd, both alone and in combination, exhibit toxicological effects in <em>A. catesbeiana</em> tadpoles, indicating a potential ecological risk associated with releasing these contaminants into aquatic environments.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107246"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2024.107198
Gabriela Helena da Silva , Jing Ji , Marcella Torres Maia , Davide Mattia , Diego Stéfani Teodoro Martinez
The increase in anthropogenic activities has led to the release of numerous chemicals and pollutants into aquatic ecosystems, raising significant concerns for water quality and health. Among the emerging issues is the interaction between pollutants and nanomaterials (mixture effects). In this work, it was studied the combined toxicity of boron nitride nanosheets (BNNS) and cadmium (Cd2+) incorporating the influence of natural organic matter (NOM) to enhance ecological relevance for the first time. Colloidal stability studies showed that BNNS is highly unstable, aggregating and precipitating over time in mineral reconstituted water. However, the addition of natural organic matter stabilizes BNNS. Acute toxicity results showed that this material has a good biocompatibility with D. magna, not causing acute toxic effect (immobility) even at high concentration (100 mg L−1). Moreover, when combined with cadmium, BNNS exhibited a "Trojan horse" effect, enhancing Cd2+ toxicity by facilitating its uptake at 1 mg L−1. 48h-EC50 values of Cd2+ and BNNS+Cd2+ were 0.21 and 0.14 mg L−1, respectively. Nevertheless, NOM (10 mg L−1) mitigated this combined toxicity effect after 48 h of exposure. These findings provide novel insights into nanomaterial-pollutant interactions linked to toxicological effects in aquatic environments, contributing to the risk assessment for the safe and sustainable development of the emerging boron nitride nanomaterials and novel products.
{"title":"Exploring the combined toxicity of boron nitride nanosheets, cadmium and natural organic matter on Daphnia magna","authors":"Gabriela Helena da Silva , Jing Ji , Marcella Torres Maia , Davide Mattia , Diego Stéfani Teodoro Martinez","doi":"10.1016/j.aquatox.2024.107198","DOIUrl":"10.1016/j.aquatox.2024.107198","url":null,"abstract":"<div><div>The increase in anthropogenic activities has led to the release of numerous chemicals and pollutants into aquatic ecosystems, raising significant concerns for water quality and health. Among the emerging issues is the interaction between pollutants and nanomaterials (mixture effects). In this work, it was studied the combined toxicity of boron nitride nanosheets (BNNS) and cadmium (Cd<sup>2+</sup>) incorporating the influence of natural organic matter (NOM) to enhance ecological relevance for the first time. Colloidal stability studies showed that BNNS is highly unstable, aggregating and precipitating over time in mineral reconstituted water. However, the addition of natural organic matter stabilizes BNNS. Acute toxicity results showed that this material has a good biocompatibility with <em>D. magna</em>, not causing acute toxic effect (immobility) even at high concentration (100 mg <em>L</em><sup>−1</sup>). Moreover, when combined with cadmium, BNNS exhibited a \"Trojan horse\" effect, enhancing Cd<sup>2+</sup> toxicity by facilitating its uptake at 1 mg <em>L</em><sup>−1</sup>. 48h-EC<sub>50</sub> values of Cd<sup>2+</sup> and BNNS+Cd<sup>2+</sup> were 0.21 and 0.14 mg <em>L</em><sup>−1</sup>, respectively. Nevertheless, NOM (10 mg <em>L</em><sup>−1</sup>) mitigated this combined toxicity effect after 48 h of exposure. These findings provide novel insights into nanomaterial-pollutant interactions linked to toxicological effects in aquatic environments, contributing to the risk assessment for the safe and sustainable development of the emerging boron nitride nanomaterials and novel products.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107198"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2024.107210
Tianyu Zhuo , Beibei Chai , Xue-yi You
Microplastic (MP) pollution poses a significant threat to aquatic ecosystems. Numerical modeling has emerged as an effective tool for predicting the distribution, accumulation, and risk assessment of MPs in aquatic ecosystems. However, published work has not systematically assessed the strengths and weaknesses of various modeling approaches. Therefore, we conducted a thorough review of the main modeling approaches for MPs over the past six years. We classified the approaches into three categories as: spatial and temporal distribution, bioaccumulation, and systematic ecological risk assessment. The review analyzed application scenarios, modeling methods, and the advantages and disadvantages of models. The results indicate that the accurate simulation of MPs spatial and temporal distribution requires reasonable parameterization and comprehensive transport considerations. Meanwhile, it is important to focus on coupling process models with other types of models. To enhance risk assessment models, expanding the relevant evaluation indicators is essential.
{"title":"Modeling the spatiotemporal distribution, bioaccumulation, and ecological risk assessment of microplastics in aquatic ecosystems: A review","authors":"Tianyu Zhuo , Beibei Chai , Xue-yi You","doi":"10.1016/j.aquatox.2024.107210","DOIUrl":"10.1016/j.aquatox.2024.107210","url":null,"abstract":"<div><div>Microplastic (MP) pollution poses a significant threat to aquatic ecosystems. Numerical modeling has emerged as an effective tool for predicting the distribution, accumulation, and risk assessment of MPs in aquatic ecosystems. However, published work has not systematically assessed the strengths and weaknesses of various modeling approaches. Therefore, we conducted a thorough review of the main modeling approaches for MPs over the past six years. We classified the approaches into three categories as: spatial and temporal distribution, bioaccumulation, and systematic ecological risk assessment. The review analyzed application scenarios, modeling methods, and the advantages and disadvantages of models. The results indicate that the accurate simulation of MPs spatial and temporal distribution requires reasonable parameterization and comprehensive transport considerations. Meanwhile, it is important to focus on coupling process models with other types of models. To enhance risk assessment models, expanding the relevant evaluation indicators is essential.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107210"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2025.107252
Pengfei Xie , Mohammad Mehdi Ommati , Deshan Chen , Weijun Chen , Lei Han , Xinquan Zhao , Hongwei Wang , Shixiao Xu , Ping Sun
The hepatotoxicity of microplastics (MPs) has garnered increasing attention, but their effects on elderly organisms remain inadequately characterized, particularly concerning hepatic stress response patterns in environmental conditions. In this study, a 10-day exposure period of elderly zebrafish to polystyrene microplastics (PS-MPs, 1 µm) was conducted, with exposure concentrations set at 5.6 × 10–7 µg/L, 5.6 × 10–4 µg/L, and 5.6 × 10–1 µg/L. PS-MPs-induced toxicity varied with concentration: superoxide dismutase (SOD), complement 3 (C3), and complement 4 (C4) initially decreased before rising; 8‑hydroxy-2-deoxyguanosine (8-OhdG), interleukin-6 (IL-6), and interleukin-8 (IL-8) increased at high concentrations. Additionally, catalase (CAT) activity and thiobarbituric acid reactive substances (TBARS) contents rose with concentration. The aged zebrafish liver exhibited differentiation driven by responsiveness; low levels cause homeostatic disruption, and high levels induce genotoxicity and immune activation. LC-MS identified twelve crucial metabolites involved in 18 metabolic pathways, including amino acids (L-tyrosine, l-arginine), lipids (phospholipids, 12(S)-leukotriene B4 and triglycerides), and N-acetylneuraminic acid, related to energy, immunity, and neurological health. Overall, elderly zebrafish exhibited clear dose-dependent thresholds and distinct physiological stress responses under varying concentrations of PS-MPs. These findings reveal how PS-MP exposure can affect physiological health and metabolism, offering critical insights into the ecological risks faced by aging organisms.
{"title":"Hepatotoxic effects of environmentally relevant concentrations of polystyrene microplastics on senescent Zebrafish (Danio rerio): Patterns of stress response and metabolomic alterations","authors":"Pengfei Xie , Mohammad Mehdi Ommati , Deshan Chen , Weijun Chen , Lei Han , Xinquan Zhao , Hongwei Wang , Shixiao Xu , Ping Sun","doi":"10.1016/j.aquatox.2025.107252","DOIUrl":"10.1016/j.aquatox.2025.107252","url":null,"abstract":"<div><div>The hepatotoxicity of microplastics (MPs) has garnered increasing attention, but their effects on elderly organisms remain inadequately characterized, particularly concerning hepatic stress response patterns in environmental conditions. In this study, a 10-day exposure period of elderly zebrafish to polystyrene microplastics (PS-MPs, 1 µm) was conducted, with exposure concentrations set at 5.6 × 10<sup>–7</sup> µg/L, 5.6 × 10<sup>–4</sup> µg/L, and 5.6 × 10<sup>–1</sup> µg/L. PS-MPs-induced toxicity varied with concentration: superoxide dismutase (SOD), complement 3 (C3), and complement 4 (C4) initially decreased before rising; 8‑hydroxy-2-deoxyguanosine (8-OhdG), interleukin-6 (IL-6), and interleukin-8 (IL-8) increased at high concentrations. Additionally, catalase (CAT) activity and thiobarbituric acid reactive substances (TBARS) contents rose with concentration. The aged zebrafish liver exhibited differentiation driven by responsiveness; low levels cause homeostatic disruption, and high levels induce genotoxicity and immune activation. LC-MS identified twelve crucial metabolites involved in 18 metabolic pathways, including amino acids (L-tyrosine, l-arginine), lipids (phospholipids, 12(<em>S</em>)-leukotriene B4 and triglycerides), and N-acetylneuraminic acid, related to energy, immunity, and neurological health. Overall, elderly zebrafish exhibited clear dose-dependent thresholds and distinct physiological stress responses under varying concentrations of PS-MPs. These findings reveal how PS-MP exposure can affect physiological health and metabolism, offering critical insights into the ecological risks faced by aging organisms.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107252"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.aquatox.2025.107254
Sadeq Abdullah Abdo Alkhadher , Lariyah Mohd Sidek , Mohamad Pauzi Zakaria , Maged Al-gradi , Suhaimi Suratman , Mohammad Sherjeel Javed Khan , Hidayah Basri , Mohd Hafiz Zawawi , Najat Masood , Tonni Agustiono Kurniawan , Sami Magam
This review article provides a thorough examination of an interaction between linear alkylbenzenes (LABs) and ecosystems. The review covers various aspects of LABs' impact on ecosystems, focusing on detection and treatment strategies to mitigate ecological consequences. It delves into LABs' role as molecular markers for sewage pollution, their physicochemical properties contributing to persistence, and their effects on aquatic and terrestrial organisms, including disruptions to endocrine systems. The diverse sources of LABs, including domestic wastewater and industrial effluents, are explored, along with their ratios in different matrices for assessing contamination origins. Biodegradation pathways of LABs, both aerobic and anaerobic, are scrutinized, considering their interaction with microbes. Distribution patterns in aquatic environments are discussed, encompassing sediment, water, sewage, and soils. An investigation is conducted on the relationship between LABs and total organic carbon (TOC) as a means of evaluating sewage pollution. It is assessed how sewage treatment facilities (STPs) contribute to biodegradation.
{"title":"Impacts of Linear Alkylbenzene (LABs) on ecosystems: Detection, fate and remediation","authors":"Sadeq Abdullah Abdo Alkhadher , Lariyah Mohd Sidek , Mohamad Pauzi Zakaria , Maged Al-gradi , Suhaimi Suratman , Mohammad Sherjeel Javed Khan , Hidayah Basri , Mohd Hafiz Zawawi , Najat Masood , Tonni Agustiono Kurniawan , Sami Magam","doi":"10.1016/j.aquatox.2025.107254","DOIUrl":"10.1016/j.aquatox.2025.107254","url":null,"abstract":"<div><div>This review article provides a thorough examination of an interaction between linear alkylbenzenes (LABs) and ecosystems. The review covers various aspects of LABs' impact on ecosystems, focusing on detection and treatment strategies to mitigate ecological consequences. It delves into LABs' role as molecular markers for sewage pollution, their physicochemical properties contributing to persistence, and their effects on aquatic and terrestrial organisms, including disruptions to endocrine systems. The diverse sources of LABs, including domestic wastewater and industrial effluents, are explored, along with their ratios in different matrices for assessing contamination origins. Biodegradation pathways of LABs, both aerobic and anaerobic, are scrutinized, considering their interaction with microbes. Distribution patterns in aquatic environments are discussed, encompassing sediment, water, sewage, and soils. An investigation is conducted on the relationship between LABs and total organic carbon (TOC) as a means of evaluating sewage pollution. It is assessed how sewage treatment facilities (STPs) contribute to biodegradation.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"279 ","pages":"Article 107254"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号