Aquatic Toxicology最新文献

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Ocean acidification aggravates the toxicity of deltamethrin in Haliotis discus hannai: Insights from immune response, histopathology and physiological responses 海洋酸化加剧了溴氰菊酯对汉娜鱼（Haliotis discus hannai）的毒性：免疫反应、组织病理学和生理反应的启示。

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2024-10-29 DOI: 10.1016/j.aquatox.2024.107139

Xiaojing Lv , Qinyou Deng , Lizhu Chen , Xin Wang , Yijing Han , Guiqing Wu , Yongliang Liu , Haiyue Sun , Xuan Li , Jinxia He , Xiangquan Liu , Dinglong Yang , Jianmin Zhao

Ocean acidification (OA) and other environmental factors can collectively affect marine organisms. Deltamethrin (DM), a type II pyrethroid insecticide, has been widely detected in coastal and estuarine areas, while little attention has been given to the combined effects of DM and OA. In this study, Haliotis discus hannai was exposed to three pH levels (8.1, 7.7 and 7.4) and three DM nominal concentrations (0 μg/L, 0.6 μg/L and 6 μg/L) for 14 and 28 days. The results indicated that experimental acidification and/or DM exposure led to impaired immune function and pathological damage. Additionally, acidified conditions and DM exposure induced oxidative stress, and gills are more sensitive than digestive glands. With increasing pCO₂ and DM nominal concentrations, superoxide dismutase (SOD) activity decreased, whereas catalase (CAT) and glutathione S-transferase (GST) activities increased in the gills. Moreover, the expression levels of Toll-like receptor (TLR) pathway-related genes were upregulated after exposure. Integrated biomarker response (IBR) analysis proved that acidified conditions and/or DM detrimentally affected the overall fitness of H. discus hannai, and co-exposure to experimental acidification and DM was the most stressful condition. This study emphasizes the necessity of incorporating OA in future pollutant environmental assessments to better elucidate the risks of environmental disturbance.

海洋酸化（OA）和其他环境因素会共同影响海洋生物。溴氰菊酯（DM）是一种II型拟除虫菊酯杀虫剂，在沿海和河口地区被广泛检测到，但很少有人关注DM和OA的综合影响。在本研究中，将汉娜藻暴露于三种 pH 值（8.1、7.7 和 7.4）和三种 DM 标称浓度（0 μg/L、0.6 μg/L 和 6 μg/L）下 14 天和 28 天。结果表明，实验性酸化和/或 DM 暴露会导致免疫功能受损和病理损伤。此外，酸化条件和DM暴露会诱发氧化应激，鳃比消化腺更敏感。随着pCO2和DM名义浓度的增加，鳃中的超氧化物歧化酶（SOD）活性降低，而过氧化氢酶（CAT）和谷胱甘肽S-转移酶（GST）活性增加。此外，与 Toll 样受体（TLR）通路相关的基因表达水平在接触后上调。综合生物标记反应（IBR）分析表明，酸化条件和/或DM对盘尾鰕虎鱼的整体适应性有不利影响，同时暴露于实验性酸化和DM条件下的盘尾鰕虎鱼应激最大。这项研究强调了将OA纳入未来污染物环境评估的必要性，以更好地阐明环境干扰的风险。

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引用次数: 0

Evaluating the impact of the combined acute toxicity of iron (Fe) and microplastics on Namalycastis jaya 评估铁（Fe）和微塑料的综合急性毒性对鲎的影响。

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2024-10-29 DOI: 10.1016/j.aquatox.2024.107141

Sakthinarenderan Saikumar , Ravi Mani , Swedha Ganesan , Mirunalini Ganesan

The rising concern over heavy metals (HMs) and microplastics (MPs) pollution in marine ecosystems, primarily driven by anthropogenic activities, poses significant threats to ecological health. Understanding the combined exposure of HMs and MPs aids in toxicity assessment. In this study, we examined the combined effects of polystyrene microplastics (MPs) and iron (Fe) on oxidative stress, bioaccumulation, histopathology, and genotoxicity in Namalycastis jaya. Oxidative stress was assessed by analyzing the levels of Superoxide dismutase (SOD), Catalase (CAT), Peroxidase (POD), Malondialdehyde (MDA), and Bicinchoninic acid (BCA), while genotoxicity was evaluated using the comet assay. Bioaccumulation analysis, conducted via Inductively coupled plasma-optical emission spectrometry (ICP-OES), indicated that the highest values (4.790 µg/ml) were observed in combined exposure, emphasizing the significant increase in iron (Fe) accumulation in polychaetes facilitated by MPs. Biochemical analysis revealed that oxidative damage in polychaetes became evident within 48 h of exposure to individual contaminants. However, in the case of combined exposures, elevated stress levels were observed within just 24 h. The genotoxic assay further demonstrated a higher degree of DNA damage in the combined exposure compared to individual exposures. Similarly, histopathology revealed mild alterations in the gut epithelium in combined exposures. It is evident that MPs intensify both oxidative and DNA damage induced by Fe in polychaetes. The insights gained from this study provide valuable information for the risk assessment of Fe and MPs in environmental safety, contributing to our understanding of the complex interactions between these pollutants in marine ecosystems.

海洋生态系统中的重金属（HMs）和微塑料（MPs）污染问题日益受到关注，这主要是人为活动造成的，对生态健康构成了重大威胁。了解重金属和微塑料的综合暴露有助于进行毒性评估。在这项研究中，我们考察了聚苯乙烯微塑料（MPs）和铁（Fe）对Namalycastis jaya的氧化应激、生物累积、组织病理学和遗传毒性的综合影响。氧化应激是通过分析超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、过氧化物酶（POD）、丙二醛（MDA）和双链霉素（BCA）的水平来评估的，而遗传毒性则是通过彗星试验来评估的。通过电感耦合等离子体-光发射光谱分析法（ICP-OES）进行的生物累积分析表明，在联合接触中观察到的最高值（4.790 微克/毫升）强调了 MPs 对多毛目环节动物体内铁（Fe）累积的显著增加。生化分析表明，在接触单种污染物 48 小时内，多毛目环节动物体内的氧化损伤变得明显。基因毒性检测进一步表明，与单独暴露相比，联合暴露中的 DNA 损伤程度更高。同样，组织病理学显示，在联合接触中，肠道上皮细胞发生了轻微的改变。很明显，MPs 会加剧多毛目动物体内由铁引起的氧化和 DNA 损伤。这项研究为铁和多溴联苯的环境安全风险评估提供了有价值的信息，有助于我们了解海洋生态系统中这些污染物之间复杂的相互作用。

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引用次数: 0

The effect of cortisone on female zebrafish (Dania rerio): Reducing reproductive capacity and offspring survival rate 可的松对雌性斑马鱼（Dania rerio）的影响：降低生殖能力和后代存活率

IF 4.1 2区环境科学与生态学 Q1 MARINE & FRESHWATER BIOLOGY

Aquatic Toxicology

Pub Date : 2024-10-28 DOI: 10.1016/j.aquatox.2024.107132

MeiXin Ye , JinLin Yang , ZiPing Cai , JunHao Wu , Wenting Xiong , LiPing Hou

Cortisone is a naturally occurring corticosteroid hormone known for its wide range of anti-inflammatory and immunosuppressive effects, and it is commonly found in various aquatic environments. Previous reports have shown that cortisone can have significant negative impacts on fish; however, its specific effects on fish reproduction have not been thoroughly investigated. In this study, female adult zebrafish were exposed to 0.0 (control), 3.9, 40.2, and 377.9 ng/L of cortisone for 60 days, and multiple endpoints were evaluated. The results showed that as the concentration of cortisone increased, there was an increase in the percentage of perinuclear oocytes and a decrease in the proportion of late-stage oocytes, indicating a stagnation in oocyte development. Additionally, female zebrafish exposed to cortisone exhibited decreased attraction to males and reduced mating intimacy. Furthermore, exposure to cortisone resulted in changes in the development and behavior of zebrafish embryos. At cortisone concentrations of 3.9 and 40.2 ng/L, fewer eggs were laid and the survival rate of fertilized eggs decreased. These observed effects are associated with abnormal transcription levels of genes (Star, Cyp11a1, Cyp17, Cyp19a, Cyp11b, Hsd11β2, Hsd17β3) related to the HPG axis. These findings provided new insights into understanding potential environmental risks associated with corticosteroids.

可的松是一种天然的皮质类固醇激素，具有广泛的消炎和免疫抑制作用，常见于各种水生环境中。以往的报告显示，可的松会对鱼类产生严重的负面影响，但其对鱼类繁殖的具体影响尚未得到深入研究。本研究将雌性成年斑马鱼暴露于 0.0（对照组）、3.9、40.2 和 377.9 纳克/升的可的松浓度下 60 天，并对多个终点进行了评估。结果显示，随着可的松浓度的增加，围核卵母细胞的比例增加，晚期卵母细胞的比例减少，表明卵母细胞发育停滞。此外，暴露于可的松的雌性斑马鱼对雄性斑马鱼的吸引力下降，交配亲密性降低。此外，暴露于可的松还会导致斑马鱼胚胎的发育和行为发生变化。可的松浓度为 3.9 和 40.2 纳克/升时，斑马鱼产卵量减少，受精卵存活率降低。这些观察到的影响与 HPG 轴相关基因（Star、Cyp11a1、Cyp17、Cyp19a、Cyp11b、Hsd11β2、Hsd17β3）的转录水平异常有关。这些发现为了解与皮质类固醇相关的潜在环境风险提供了新的视角。

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