Aim: The aim of this study was to examine self-compassion, temperament types and cognitive flexibility characteristics of individuals residing in Istanbul, Turkey aged between 16 and 85 years who never cheated and who cheated at least once. Material and Method: The sample of this study consists of 93 individuals who never cheated and 83 individuals who cheated at least once, residing in Istanbul, Turkey aged between 16 and 85 years. The sample was selected by using simple random sampling. The sample was administered Sociodemographic Form, Deception Tendency Scale (DTS), Self-Compassion Scale (SCS), Temperament Evaluation of Memphis, Pisa, Paris, San Diego-Autoquestionnaire (TEMPS-A) and Cognitive Flexibility Scale (CFS). First, it was checked whether there was a normal distribution or not. For this, skewness and kurtosis values were checked. This study was carried out by the relational screening model, one of the quantitative research methods. Statistical evaluations were analyzed using SPSS (Statistical Package for Social Sciences) 25.0. Results: The results of this study showed that there was a significant difference between self-compassion components: self-judgment, common humanity, isolation, and over-identification scores of individuals with and without tendency to deceive (p
目的:本研究的目的是考察居住在土耳其伊斯坦布尔的16 - 85岁从未欺骗过和至少欺骗过一次的个体的自我同情、气质类型和认知灵活性特征。材料与方法:本研究的样本包括93名从未欺骗过的人和83名至少欺骗过一次的人，他们居住在土耳其伊斯坦布尔，年龄在16至85岁之间。采用简单随机抽样的方法选取样本。采用社会人口学量表、欺骗倾向量表(DTS)、自我同情量表(SCS)、孟菲斯、比萨、巴黎、圣地亚哥气质评价问卷(TEMPS-A)和认知灵活性量表(CFS)对被试进行问卷调查。首先，检查是否存在正态分布。为此，检查了偏度和峰度值。本研究采用定量研究方法之一的关系筛选模型进行。统计评价采用SPSS (Statistical Package for Social Sciences) 25.0进行分析。结果:本研究结果显示，有欺骗倾向和无欺骗倾向个体的自我同情成分:自我判断、共同人性、孤立和过度认同得分之间存在显著差异(p
{"title":"An examination of the relationship between self-compassion, temperament types and cognitive flexibility according to deceiving tendency","authors":"O. Demirci, Kahraman Güler","doi":"10.38053/acmj.1252898","DOIUrl":"https://doi.org/10.38053/acmj.1252898","url":null,"abstract":"Aim: The aim of this study was to examine self-compassion, temperament types and cognitive flexibility characteristics of individuals residing in Istanbul, Turkey aged between 16 and 85 years who never cheated and who cheated at least once. \u0000Material and Method: The sample of this study consists of 93 individuals who never cheated and 83 individuals who cheated at least once, residing in Istanbul, Turkey aged between 16 and 85 years. The sample was selected by using simple random sampling. The sample was administered Sociodemographic Form, Deception Tendency Scale (DTS), Self-Compassion Scale (SCS), Temperament Evaluation of Memphis, Pisa, Paris, San Diego-Autoquestionnaire (TEMPS-A) and Cognitive Flexibility Scale (CFS). First, it was checked whether there was a normal distribution or not. For this, skewness and kurtosis values were checked. This study was carried out by the relational screening model, one of the quantitative research methods. Statistical evaluations were analyzed using SPSS (Statistical Package for Social Sciences) 25.0. \u0000Results: The results of this study showed that there was a significant difference between self-compassion components: self-judgment, common humanity, isolation, and over-identification scores of individuals with and without tendency to deceive (p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115300576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The formation of scars on the face after open septorhinoplasty (SRP) with alar base reduction may disturb the patient due to cosmetic concerns. This study aimed to compare scar outcomes of the columella and alar base in patients undergoing SRP. Material and Method: Twenty-seven patients who underwent alar base reduction during primary open SRP were divided into two groups according to the intervened area as the Columella (CLM) group (n=27) and the Alar Base (AB) group (n=27). Irradiated polyglactin 911 was used in all patients. The modified Stony Brook Scar Evaluation Scale (SBSES) and a questionnaire form were used to measure scar outcomes and patient satisfaction. Columellar and alar base scar outcomes were compared. Results: Patient satisfaction and scar outcomes were better in the CLM group. There was no significant difference, except for the first month total SBSES scores, between the CLM and AB groups. There was no significant difference in patient questionnaire scores between groups. In the early period, there were more signs of inflammation in the alar base than in the columella, without statistical significance. Conclusion: Patient satisfaction and scar outcomes in the columellar area were favorable. Scar outcome on the alar base was statistically significantly worse than columella in the early period. There was no statistically significant difference between both areas in the long-term. Irradiated rapid vicryl can be used for closure of the alar base and columella, considering its advantages and disadvantages, in patients undergoing open septorhinoplasty with alar base reduction.
{"title":"Comparison of scar outcomes of alar base and columella using irradiated polyglactin 911: a single-blind study","authors":"M. Ceylan, T. Yücel","doi":"10.38053/acmj.1249691","DOIUrl":"https://doi.org/10.38053/acmj.1249691","url":null,"abstract":"Aim: The formation of scars on the face after open septorhinoplasty (SRP) with alar base reduction may disturb the patient due to cosmetic concerns. This study aimed to compare scar outcomes of the columella and alar base in patients undergoing SRP. \u0000Material and Method: Twenty-seven patients who underwent alar base reduction during primary open SRP were divided into two groups according to the intervened area as the Columella (CLM) group (n=27) and the Alar Base (AB) group (n=27). Irradiated polyglactin 911 was used in all patients. The modified Stony Brook Scar Evaluation Scale (SBSES) and a questionnaire form were used to measure scar outcomes and patient satisfaction. Columellar and alar base scar outcomes were compared. \u0000Results: Patient satisfaction and scar outcomes were better in the CLM group. There was no significant difference, except for the first month total SBSES scores, between the CLM and AB groups. There was no significant difference in patient questionnaire scores between groups. In the early period, there were more signs of inflammation in the alar base than in the columella, without statistical significance. \u0000Conclusion: Patient satisfaction and scar outcomes in the columellar area were favorable. Scar outcome on the alar base was statistically significantly worse than columella in the early period. There was no statistically significant difference between both areas in the long-term. Irradiated rapid vicryl can be used for closure of the alar base and columella, considering its advantages and disadvantages, in patients undergoing open septorhinoplasty with alar base reduction.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134476369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To characterize the patient groups referred to the ophthalmology clinic from the pediatrics clinic and to determine the frequency of the findings. Material and Method: The patients consulted to Balıkesir University Eye Clinic by the Pediatrics Clinic were evaluated retrospectively. Patients were divided into rule-out and ocular symptom groups. Reasons for consultation and ocular findings were recorded. Results: The mean age of 116 patients included in the study was 8.04±4.11 years. Of the patients included in the study, 75 (64.7%) rule-out 41 (35.3%) were in the ocular symptom group. 41 (54.7%) patients in the rule-out group were those who applied for headaches and requested an examination of the fundus and optic disc. Papilledema was detected in 7 (17.1%) patients with headache. Of the patients in the ocular symptom group, 11 (26.8%) were consulted for ocular trauma, 11 (26.8%) for red eye, and 7 (17.1%) for preseptal/orbital cellulitis. Preseptal cellulitis was detected in 4 (57.1%) patients consulted for preseptal/orbital cellulitis. Ocular findings were detected in 10 (91%) patients consulted for trauma. Conjunctivitis was detected in 9 (81.8%) patients who were consulted with red eyes. Conclusion: In the pediatric age group, ophthalmic consultation is mainly performed due to rule-out. The most common reason is the examination of the fundus of the eye due to headache. It is crucial for pediatric age groups to consult an ophthalmologist by performing an eye and vision examination by a pediatrician in terms of early diagnosis and treatment.
{"title":"Evaluation of pediatric ophthalmic consultations in a tertiary care university hospital","authors":"A. G. Taslipinar Uzel, Özlem Özcanli Çay, M. Uzel","doi":"10.38053/acmj.1233818","DOIUrl":"https://doi.org/10.38053/acmj.1233818","url":null,"abstract":"Aim: To characterize the patient groups referred to the ophthalmology clinic from the pediatrics clinic and to determine the frequency of the findings. \u0000Material and Method: The patients consulted to Balıkesir University Eye Clinic by the Pediatrics Clinic were evaluated retrospectively. Patients were divided into rule-out and ocular symptom groups. Reasons for consultation and ocular findings were recorded. \u0000Results: The mean age of 116 patients included in the study was 8.04±4.11 years. Of the patients included in the study, 75 (64.7%) rule-out 41 (35.3%) were in the ocular symptom group. 41 (54.7%) patients in the rule-out group were those who applied for headaches and requested an examination of the fundus and optic disc. Papilledema was detected in 7 (17.1%) patients with headache. Of the patients in the ocular symptom group, 11 (26.8%) were consulted for ocular trauma, 11 (26.8%) for red eye, and 7 (17.1%) for preseptal/orbital cellulitis. Preseptal cellulitis was detected in 4 (57.1%) patients consulted for preseptal/orbital cellulitis. Ocular findings were detected in 10 (91%) patients consulted for trauma. Conjunctivitis was detected in 9 (81.8%) patients who were consulted with red eyes. \u0000Conclusion: In the pediatric age group, ophthalmic consultation is mainly performed due to rule-out. The most common reason is the examination of the fundus of the eye due to headache. It is crucial for pediatric age groups to consult an ophthalmologist by performing an eye and vision examination by a pediatrician in terms of early diagnosis and treatment.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133574196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Contrast-induced nephropathy (CIN), a significant complication of percutaneous coronary intervention (PCI), is related to increased morbidity and mortality. It has been suggested that inflammation plays an important role in the development of CIN. This study aimed to investigate the prognostic role of the CANLPH score, a new indicator of inflammation, in predicting CIN and in-hospital mortality among patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI. Material and Method: This retrospective study included 1475 patients with STEMI undergoing PCI. CIN was defined as a 25% or 0.5 mg/dL increase in serum creatinine compared to the baseline value within 48 h after PCI. The preprocedural modified Mehran score was calculated for each patient. The CANLPH score was derived from the cut-off points of the platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and platelet/hemoglobin ratio to predict CIN. Results: The mean age of the patients was 62.0±14.3 years and the majority were male (69.8%). The incidence of CIN was determined as 11.5%. Multivariable regression analysis showed that increased CANLPH score (OR=4.49, p
目的:造影剂肾病(CIN)是经皮冠状动脉介入治疗(PCI)的一个重要并发症，与发病率和死亡率增加有关。有研究表明炎症在CIN的发展中起重要作用。本研究旨在探讨CANLPH评分(一种新的炎症指标)在st段抬高型心肌梗死(STEMI)行PCI的患者中预测CIN和住院死亡率的预后作用。材料与方法:本回顾性研究纳入1475例STEMI患者行PCI。CIN定义为PCI术后48小时内血清肌酐较基线值升高25%或0.5 mg/dL。计算每位患者的术前改良Mehran评分。CANLPH评分由血小板/淋巴细胞比值、中性粒细胞/淋巴细胞比值和血小板/血红蛋白比值的截断点得出，用于预测CIN。结果:患者平均年龄62.0±14.3岁，以男性居多(69.8%)。CIN的发生率为11.5%。多变量回归分析显示，CANLPH评分升高(OR=4.49, p
{"title":"ST segment yükselmeli miyokard enfarktüsü olan hastalarda kontrast maddeye bağlı nefropati ile CANLPH skoru arasındaki ilişki","authors":"Ozlem OZCAN CELEBİ, Birsen Doğanay","doi":"10.38053/acmj.1249896","DOIUrl":"https://doi.org/10.38053/acmj.1249896","url":null,"abstract":"Aim: Contrast-induced nephropathy (CIN), a significant complication of percutaneous coronary intervention (PCI), is related to increased morbidity and mortality. It has been suggested that inflammation plays an important role in the development of CIN. This study aimed to investigate the prognostic role of the CANLPH score, a new indicator of inflammation, in predicting CIN and in-hospital mortality among patients with ST-segment elevation myocardial infarction (STEMI) undergoing PCI. \u0000Material and Method: This retrospective study included 1475 patients with STEMI undergoing PCI. CIN was defined as a 25% or 0.5 mg/dL increase in serum creatinine compared to the baseline value within 48 h after PCI. The preprocedural modified Mehran score was calculated for each patient. The CANLPH score was derived from the cut-off points of the platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and platelet/hemoglobin ratio to predict CIN. \u0000Results: The mean age of the patients was 62.0±14.3 years and the majority were male (69.8%). The incidence of CIN was determined as 11.5%. Multivariable regression analysis showed that increased CANLPH score (OR=4.49, p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133894980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Dry mouth has been considered a clinical finding of Parkinson’s disease (PD), but we think otherwise. We studied if the olfactory bulbectomy (OBX) might rely on the superior salivatory nucleus (SSN), submandibular ganglia (SMGn), and submandibular glands (SLGl) circuity disruption induced submandibular gland degeneration related dry mouth in rats. Material and Method: This study was carried out on twenty-six male rats. Five (GI-n=5), six (GII, n=6), and sixteen (GIII, n=15) of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment (1/day), and animals were decapitated. The olfactory bulb volumes (mm3), degenerated neuron densities of SSN/SMG (n/mm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSN/SMGn/SMGl follicles volumes were compared statistically. Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes (mm3), degenerated neuron density of SSN (n/mm3), SMGn (n/mm3), and follicles volumes of SMGl (cubic micrometer/mm3) were measured in the order written as; (4.27±0.21), (4±1), (5±2), (81.23±13.34).106 in GI; (3.67±0.33), (14±3), (17±4), (72.45±11.78).106 in GII and (2.91±0.14), (23±5), (29±8), (57.19±11.93).106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p
{"title":"New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study","authors":"M. Zeynal","doi":"10.38053/acmj.1242763","DOIUrl":"https://doi.org/10.38053/acmj.1242763","url":null,"abstract":"Aim: Dry mouth has been considered a clinical finding of Parkinson’s disease (PD), but we think otherwise. We studied if the olfactory bulbectomy (OBX) might rely on the superior salivatory nucleus (SSN), submandibular ganglia (SMGn), and submandibular glands (SLGl) circuity disruption induced submandibular gland degeneration related dry mouth in rats. \u0000Material and Method: This study was carried out on twenty-six male rats. Five (GI-n=5), six (GII, n=6), and sixteen (GIII, n=15) of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment (1/day), and animals were decapitated. The olfactory bulb volumes (mm3), degenerated neuron densities of SSN/SMG (n/mm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSN/SMGn/SMGl follicles volumes were compared statistically. \u0000Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes (mm3), degenerated neuron density of SSN (n/mm3), SMGn (n/mm3), and follicles volumes of SMGl (cubic micrometer/mm3) were measured in the order written as; (4.27±0.21), (4±1), (5±2), (81.23±13.34).106 in GI; (3.67±0.33), (14±3), (17±4), (72.45±11.78).106 in GII and (2.91±0.14), (23±5), (29±8), (57.19±11.93).106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127944760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet Onat Çakit, G. Koca, A. Akbulut, O. Erdem, S. Çetinkaya, Gaye Umurhan, Nur Aydinbelge-Dizdar, M. Esmekaya, N. Yumuşak, Ayse Gulnihal Canseven Kursun, M. Korkmaz
Aim: The aim of this study was to investigate the effects of 1mT, 1.5 mT, and 2 mT extremely low-frequency magnetic fields, which were within the limits for public environmental and occupational magnetic field exposure guidelines, on apoptosis, neurodegeneration and trace elements in rat brain cells. Material and Method: A total of 35 adult male Wistar rats were allocated into four main groups: Group 1 (n=8) was healthy controls; Group 2 (n=9) was exposed to 1 mT extremely low-frequency magnetic field; Group 3 (n=9) was exposed to 1.5 mT extremely low-frequency magnetic field and Group 4 (n=9) was exposed to 2 mT extremely low-frequency magnetic field. All the rats in the exposure groups were exposed to 50 Hz extremely low-frequency magnetic field for 4 hours per day, 5 days per week for 30 days in the Helmholtz coils. After the exposure, rats were sacrificed and rat brains were evaluated for histopathological and immunohistochemical changes as well as about the trace element levels in the brain. Results: Different levels of exposure to extremely low-frequency magnetic field doses caused increases in Ca levels and increased apoptosis in the rat brain. As the applied extremely low-frequency magnetic field levels increased, so did the apoptosis and Ca levels in the brain tissues. Conclusion: Extremely low-frequency magnetic field exposure caused neurodegeneration in rat brain tissue, increased apoptosis, and increased Ca concentration. These changes may cause various biological damage, especially cancer in healthy tissues and measures should be taken to minimize extremely low-frequency magnetic field exposure in daily life in terms of protecting public health.
{"title":"The effects of extremely low-frequency magnetic field exposure on apoptosis, neurodegeneration and trace element levels in the rat brain","authors":"Mehmet Onat Çakit, G. Koca, A. Akbulut, O. Erdem, S. Çetinkaya, Gaye Umurhan, Nur Aydinbelge-Dizdar, M. Esmekaya, N. Yumuşak, Ayse Gulnihal Canseven Kursun, M. Korkmaz","doi":"10.38053/acmj.1245104","DOIUrl":"https://doi.org/10.38053/acmj.1245104","url":null,"abstract":"Aim: The aim of this study was to investigate the effects of 1mT, 1.5 mT, and 2 mT extremely low-frequency magnetic fields, which were within the limits for public environmental and occupational magnetic field exposure guidelines, on apoptosis, neurodegeneration and trace elements in rat brain cells. \u0000Material and Method: A total of 35 adult male Wistar rats were allocated into four main groups: Group 1 (n=8) was healthy controls; Group 2 (n=9) was exposed to 1 mT extremely low-frequency magnetic field; Group 3 (n=9) was exposed to 1.5 mT extremely low-frequency magnetic field and Group 4 (n=9) was exposed to 2 mT extremely low-frequency magnetic field. All the rats in the exposure groups were exposed to 50 Hz extremely low-frequency magnetic field for 4 hours per day, 5 days per week for 30 days in the Helmholtz coils. After the exposure, rats were sacrificed and rat brains were evaluated for histopathological and immunohistochemical changes as well as about the trace element levels in the brain. \u0000Results: Different levels of exposure to extremely low-frequency magnetic field doses caused increases in Ca levels and increased apoptosis in the rat brain. As the applied extremely low-frequency magnetic field levels increased, so did the apoptosis and Ca levels in the brain tissues. \u0000Conclusion: Extremely low-frequency magnetic field exposure caused neurodegeneration in rat brain tissue, increased apoptosis, and increased Ca concentration. These changes may cause various biological damage, especially cancer in healthy tissues and measures should be taken to minimize extremely low-frequency magnetic field exposure in daily life in terms of protecting public health.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"120 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133755045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The ratio of hemoglobin (Hb) to red cell distribution width (RDW) (HRR) has been defined as an effective prognostic factor in various cancer types. The aim of this study is to investigate the prognostic role of HRR value in small cell lung cancer (SCLC). Material and Method: A total of 1039 patients diagnosed with SCLC between 2010-2021 were included in the study. After exclusion of 199 patients without positron emission tomography-computerized tomography (PET-CT), age, gender, additional disease histories, smoking history, pathological stages, survival status, disease progression times, treatments applied, first hemoglobin obtained after diagnosis, red cell distribution width and ratios, and other laboratory parameters of 840 patients were recorded. The log-rank test and the Cox proportional hazards model were used to identify predictors of mortality. Results: A total of 840 patients were included in the study. The median overall survival (OS) and the progression-free survival (PS) times of the patients were 9 months, and 7 months, respectively. The cut-off value for HRR was determined 0.580 (sensitivity 78.73%, specificity 37.88%). In this study, each one-unit increase in HRR reduces death and survival by 1.6 times detected, and it was revealed that HRR had a statistically significant effect on OS and PS. When the patients were divided into two as limited and extensive disease, there was a statistically significant difference between the groups in terms of OS (12-6 months) and PS (10-6 months), but no significant difference was found in terms of HRR between these two groups. Conclusion: HRR is an easily accessible, inexpensive parameter that can be used as a prognostic marker in patients with SCLC.
{"title":"A new prognostic marker in small cell lung cancer: red cell distribution width ratio of hemoglobin","authors":"Figen Öztürk Ergür, Ayperi Öztürk","doi":"10.38053/acmj.1259439","DOIUrl":"https://doi.org/10.38053/acmj.1259439","url":null,"abstract":"Aim: The ratio of hemoglobin (Hb) to red cell distribution width (RDW) (HRR) has been defined as an effective prognostic factor in various cancer types. The aim of this study is to investigate the prognostic role of HRR value in small cell lung cancer (SCLC). \u0000Material and Method: A total of 1039 patients diagnosed with SCLC between 2010-2021 were included in the study. After exclusion of 199 patients without positron emission tomography-computerized tomography (PET-CT), age, gender, additional disease histories, smoking history, pathological stages, survival status, disease progression times, treatments applied, first hemoglobin obtained after diagnosis, red cell distribution width and ratios, and other laboratory parameters of 840 patients were recorded. The log-rank test and the Cox proportional hazards model were used to identify predictors of mortality. \u0000Results: A total of 840 patients were included in the study. The median overall survival (OS) and the progression-free survival (PS) times of the patients were 9 months, and 7 months, respectively. The cut-off value for HRR was determined 0.580 (sensitivity 78.73%, specificity 37.88%). In this study, each one-unit increase in HRR reduces death and survival by 1.6 times detected, and it was revealed that HRR had a statistically significant effect on OS and PS. When the patients were divided into two as limited and extensive disease, there was a statistically significant difference between the groups in terms of OS (12-6 months) and PS (10-6 months), but no significant difference was found in terms of HRR between these two groups. \u0000Conclusion: HRR is an easily accessible, inexpensive parameter that can be used as a prognostic marker in patients with SCLC.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115448476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To evaluate the functional and anatomic efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with diabetic macular edema (DME) and investigate the association between central macular thickness (CMT) and total macular volume (TMV) in real-life settings.Material and Method: In this retrospective, observational, longitudinal study 38 eyes of 23 consecutive patients with center-involving DME were included. A loading phase of three monthly intravitreal anti-VEGF injections was initiated, followed by anti-VEGF injections if needed as per clinicians’ discretion. Results: Mean Early Treatment Diabetic Retinopathy Study (ETDRS) letters gained was 3.2 letters at month 12. The reduction in the mean of CMT and TMV were 60 μm and 1.33 mm3 respectively at the end of 12 months. Best-corrected visual acuity (BCVA) was negatively correlated with CMT (r=-0.573, p < 0.01) and TMV (r=-0.533, p < 0.01) initially. There was a statistically significant positive correlation between the CMT and the TMV initially (r=0.765, p < 0.01) and month 12 (r=0.937, p < 0.01). Baseline TMV was found to be more predictive of treatment response at the 9th month than baseline CMT. Conclusion: It is demonstrated that TMV may be a suitable biomarker in the assessment of treatment response of the macular region when regarded as a complete three-dimensional macular unit instead of central vertical thickness only. Although the present study contributes to a better understanding of managing DME in real-life settings, further prospective, and controlled investigations are needed.
目的:评价玻璃体内抗血管内皮生长因子(anti-VEGF)治疗糖尿病性黄斑水肿(DME)的功能和解剖效果，探讨现实生活中黄斑中央厚度(CMT)与黄斑总体积(TMV)的关系。材料与方法:在这项回顾性、观察性、纵向研究中，纳入了23例连续累及中心的DME患者的38只眼。开始了每月3次玻璃体内抗vegf注射的加载阶段，随后根据临床医生的判断需要进行抗vegf注射。结果:12个月时，早期治疗糖尿病视网膜病变研究(ETDRS)的平均字母增加为3.2个字母。12个月后，CMT和TMV的平均值分别下降了60 μm和1.33 mm3。最佳矫正视力(BCVA)与CMT (r=-0.573, p < 0.01)、TMV (r=-0.533, p < 0.01)初始呈负相关。CMT与TMV初始值(r=0.765, p < 0.01)和第12个月(r=0.937, p < 0.01)呈正相关，有统计学意义。发现基线TMV比基线CMT更能预测第9个月的治疗反应。结论:TMV作为一个完整的三维黄斑单元，而不仅仅是中心垂直厚度，可以作为评价黄斑区域治疗效果的一个合适的生物标志物。虽然目前的研究有助于更好地理解在现实环境中管理二甲醚，但需要进一步的前瞻性和对照调查。
{"title":"Total macular volume as a potential biomarker in the assessment of anti-VEGF response in patients with diabetic macular edema: real-life data analysis","authors":"Eren Ekici, A. K. Kocak altintas","doi":"10.38053/acmj.1205486","DOIUrl":"https://doi.org/10.38053/acmj.1205486","url":null,"abstract":"Aim: To evaluate the functional and anatomic efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with diabetic macular edema (DME) and investigate the association between central macular thickness (CMT) and total macular volume (TMV) in real-life settings.Material and Method: In this retrospective, observational, longitudinal study 38 eyes of 23 consecutive patients with center-involving DME were included. A loading phase of three monthly intravitreal anti-VEGF injections was initiated, followed by anti-VEGF injections if needed as per clinicians’ discretion. Results: Mean Early Treatment Diabetic Retinopathy Study (ETDRS) letters gained was 3.2 letters at month 12. The reduction in the mean of CMT and TMV were 60 μm and 1.33 mm3 respectively at the end of 12 months. Best-corrected visual acuity (BCVA) was negatively correlated with CMT (r=-0.573, p < 0.01) and TMV (r=-0.533, p < 0.01) initially. There was a statistically significant positive correlation between the CMT and the TMV initially (r=0.765, p < 0.01) and month 12 (r=0.937, p < 0.01). Baseline TMV was found to be more predictive of treatment response at the 9th month than baseline CMT. Conclusion: It is demonstrated that TMV may be a suitable biomarker in the assessment of treatment response of the macular region when regarded as a complete three-dimensional macular unit instead of central vertical thickness only. Although the present study contributes to a better understanding of managing DME in real-life settings, further prospective, and controlled investigations are needed.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114416179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Şipal, Meliha Turksever, Hatice Tezcan, E. Yuvanç
Guillain Barre syndrome (GBS) is the most common neurological cause of acute flaccid paralysis worldwide. Early diagnosis and treatment of GBS are vital due to possible deadly consequences. Awareness of the silent neurological symptoms in patients preparing for upcoming surgery may have critically crucial for a urologist. Developing GBS after relieving urosepsis is rarely addressed in the literature. Therefore, this report presents an infrequent complication of Escherichia coli (E. coli)-induced urosepsis, GBS. A 47-year-old female patient was admitted to the emergency department in a septic state. During the intensive care unit management with the preliminary diagnosis of sepsis-related hypovolemic shock, a nephrostomy catheter was placed in an obstructed left kidney due to impacted upper ureteral calculus with 1.5 cm in size. Following the improvement of the patient’s condition in intensive care unit with proper management, the patient was transferred to the urology ward for definitive treatment. During the follow-up, however, the patient showed some neurological signs and symptoms considering GBS. An obtained cerebral spinal fluid analysis revealed an albumin-cytologic dissociation and examining the patient underpinned the diagnosis. The patient was treated with intravenous immunoglobulin for five days, according to the guidlines. After the treatment, the patient’s condition improved rapidly following two weeks. The left obstructed ureteral stones were removed with ureteroscopy. A stone-free status was achieved the following month. GBS is the most common cause of acute flaccid paralysis worldwide, and proper management is essential due to poor prognosis. GBS after a uroseptic condition is sporadic, but any surgery on patients who experience active GBS would bode for severe consequences, so awareness of the silent neurological symptoms in patients prepared for upcoming surgery is vital for a urologist. We aimed to remind with this report of the possibility of GBS for a patient who expresses neurological symptoms following a septic state.
{"title":"A rare complication of Escherichia coli induced urosepsis; is Guillain-Barre syndrome","authors":"T. Şipal, Meliha Turksever, Hatice Tezcan, E. Yuvanç","doi":"10.38053/acmj.1206669","DOIUrl":"https://doi.org/10.38053/acmj.1206669","url":null,"abstract":"Guillain Barre syndrome (GBS) is the most common neurological cause of acute flaccid paralysis worldwide. Early diagnosis and treatment of GBS are vital due to possible deadly consequences. Awareness of the silent neurological symptoms in patients preparing for upcoming surgery may have critically crucial for a urologist. Developing GBS after relieving urosepsis is rarely addressed in the literature. Therefore, this report presents an infrequent complication of Escherichia coli (E. coli)-induced urosepsis, GBS. A 47-year-old female patient was admitted to the emergency department in a septic state. During the intensive care unit management with the preliminary diagnosis of sepsis-related hypovolemic shock, a nephrostomy catheter was placed in an obstructed left kidney due to impacted upper ureteral calculus with 1.5 cm in size. Following the improvement of the patient’s condition in intensive care unit with proper management, the patient was transferred to the urology ward for definitive treatment. During the follow-up, however, the patient showed some neurological signs and symptoms considering GBS. An obtained cerebral spinal fluid analysis revealed an albumin-cytologic dissociation and examining the patient underpinned the diagnosis. The patient was treated with intravenous immunoglobulin for five days, according to the guidlines. After the treatment, the patient’s condition improved rapidly following two weeks. The left obstructed ureteral stones were removed with ureteroscopy. A stone-free status was achieved the following month. GBS is the most common cause of acute flaccid paralysis worldwide, and proper management is essential due to poor prognosis. GBS after a uroseptic condition is sporadic, but any surgery on patients who experience active GBS would bode for severe consequences, so awareness of the silent neurological symptoms in patients prepared for upcoming surgery is vital for a urologist. We aimed to remind with this report of the possibility of GBS for a patient who expresses neurological symptoms following a septic state. ","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129764008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayşe Şeyma Küçükakça, M. Ağar, N. Dokuzeylül Güngör, T. Gürbüz
Aim: This study investigated the risk of premature progesterone (P4) rise in the fixed and sequential estradiol valerate (EV) administration for frozen embryo transfer (FET) cycles.Material and Method: In this cross-sectional case-control study, 1272 cycles of FET were analyzed retrospectively from computer records between January 2015 to August 2020. EV was administrated in 795 patients with a fixed dose and in 477 patients with a sequential dose. P4 values were measured on the day when the endometrial thickness reached 8 mm in the patients.Results: There were 795 patients in the fixed EV administration group with a mean age of 30.75±3.39 and 477 patients in the sequential EV administration with a mean age of 30.75±3.39. P4 of the sequential-dose group (1.05±0.31) was significantly higher than the fixed-dose group (1.01±0.33). The Pairwise Z-Tests found that the abort rate was significantly higher in the sequential-dose group (p=0.04).Conclusion: Our results showed a higher P4 and abortion rate in the sequential-dose group. These findings show that premature P4 rise can be considered a risk factor.
{"title":"Effects of sequential and fixed-dose estradiol valerate administration on premature progesterone rise in frozen-thawed embryo transfer cycles","authors":"Ayşe Şeyma Küçükakça, M. Ağar, N. Dokuzeylül Güngör, T. Gürbüz","doi":"10.38053/acmj.1209514","DOIUrl":"https://doi.org/10.38053/acmj.1209514","url":null,"abstract":"Aim: This study investigated the risk of premature progesterone (P4) rise in the fixed and sequential estradiol valerate (EV) administration for frozen embryo transfer (FET) cycles.Material and Method: In this cross-sectional case-control study, 1272 cycles of FET were analyzed retrospectively from computer records between January 2015 to August 2020. EV was administrated in 795 patients with a fixed dose and in 477 patients with a sequential dose. P4 values were measured on the day when the endometrial thickness reached 8 mm in the patients.Results: There were 795 patients in the fixed EV administration group with a mean age of 30.75±3.39 and 477 patients in the sequential EV administration with a mean age of 30.75±3.39. P4 of the sequential-dose group (1.05±0.31) was significantly higher than the fixed-dose group (1.01±0.33). The Pairwise Z-Tests found that the abort rate was significantly higher in the sequential-dose group (p=0.04).Conclusion: Our results showed a higher P4 and abortion rate in the sequential-dose group. These findings show that premature P4 rise can be considered a risk factor.","PeriodicalId":307693,"journal":{"name":"Anatolian Current Medical Journal","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124274508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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