A. Molua, E. Matondo, Michel Tshikuela Lelo, J. Mukaya, A. Mbongo, T. Mazoba
Context and objective. The pancreas being a deep organ, its clinical exploration is sometimes limited and inefficient. The diagnosis of pancreatic pathologies is mainly based on the dosage of pancreatic enzymes (lipasemia in particular) and medical imaging. The objective of the present study was to describe the scanographic profile of pancreatic tumors in 3 radiology departments in Kinshasa. Methods. It was a retrospective serial case study conducted in 3 radiology departments in Kinshasa from January 2016 to June 2021, having retained 86 reports of abdominal computed tomography (CT) scan of patients with pancreatic pathology. Results. 66 cases of pancreatic tumors were involved. Male patients were predominant (sex-ratio M/F=1.6) and the mean age of 55.7 ± 14.7 years (range: 16 to 92 years). Cholestasis syndrome (50 %) and abdominal (epigastric) pain were the most common indications. In tumors, the contours were lobulated (56.1 %). The Wirsung duct was dilated in most tumors. The tumors were resectable in 26 % of cases. Conclusion. The abdominal CT-scan contributes to the diagnosis of pancreatic pathologies. These pathologies mostly affect male elderly subjects, are predominantly tumoral and generally diagnosed in late unresectable stage.
{"title":"Scanographic profile tumors from 3 radiology division in Kinshasa: retrospective serial cases","authors":"A. Molua, E. Matondo, Michel Tshikuela Lelo, J. Mukaya, A. Mbongo, T. Mazoba","doi":"10.4314/aamed.v15i4.6","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.6","url":null,"abstract":"Context and objective. The pancreas being a deep organ, its clinical exploration is sometimes limited and inefficient. The diagnosis of pancreatic pathologies is mainly based on the dosage of pancreatic enzymes (lipasemia in particular) and medical imaging. The objective of the present study was to describe the scanographic profile of pancreatic tumors in 3 radiology departments in Kinshasa. Methods. It was a retrospective serial case study conducted in 3 radiology departments in Kinshasa from January 2016 to June 2021, having retained 86 reports of abdominal computed tomography (CT) scan of patients with pancreatic pathology. Results. 66 cases of pancreatic tumors were involved. Male patients were predominant (sex-ratio M/F=1.6) and the mean age of 55.7 ± 14.7 years (range: 16 to 92 years). Cholestasis syndrome (50 %) and abdominal (epigastric) pain were the most common indications. In tumors, the contours were lobulated (56.1 %). The Wirsung duct was dilated in most tumors. The tumors were resectable in 26 % of cases. Conclusion. The abdominal CT-scan contributes to the diagnosis of pancreatic pathologies. These pathologies mostly affect male elderly subjects, are predominantly tumoral and generally diagnosed in late unresectable stage.","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82001181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute angina is mostly viral, but Bacterial angina is mainly related to the group of streptococci (group A beta-hemolytic). Other unusual bacterial strains are sometimes found, which requires an adapted and gradual clinical approach including the use of microbiological diagnostic means. We report an observation of acute angina caused by Klebsiella pneumoniae, an unusual bacterial agent requiring an appropriate response.
{"title":"About one observation of an acute Klebsiella pneumoniae tonsillitis","authors":"Smail Kharoubi","doi":"10.4314/aamed.v15i4.13","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.13","url":null,"abstract":"Acute angina is mostly viral, but Bacterial angina is mainly related to the group of streptococci (group A beta-hemolytic). Other unusual bacterial strains are sometimes found, which requires an adapted and gradual clinical approach including the use of microbiological diagnostic means. We report an observation of acute angina caused by Klebsiella pneumoniae, an unusual bacterial agent requiring an appropriate response.","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88205466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Anzouan-Kacou, Maire Dehinsala, A. Bangoura, D. H. Kouamé, Adjéka Stanislas Doffou, A. Mahassadi, F. B. Yao, A. Attia
Context and objectives. Chronic viral hepatitis is a public health problem in Côte-d’Ivoire. A significant number of patients have little access to treatment due to the high costs of assessment and treatment. The objective of our study was to evaluate the costs of assessments and treatment of chronic viral hepatitis. Methods. This was an analytical cross-sectional observational study from March 1, 2019 to July 31, 2019 in the Hepato- Gastroenterology Consultation Service at the Yopougon University Hospital. The variables studied were socio-demographic and economic parameters. Results. 136 patients (men 53.6 %, average age 42 ± 12.2 years) were included. More than half of the patients (63.3 %) had a monthly income not exceeding 490.39 USD. The cost ofthe initial assessment was 223.13 USD and 351.14 USD for viral hepatitis B and C, respectively. Tenofovir and pegylated interferon were free of charge. Treatment with sofosbuvir + velpastavir cost 593.37 USD. The annual follow-up assessment was estimated at 237.02 USD for viral hepatitis B and 225.58 USD for viral hepatitis C. Conclusion. The assessment and treatment of chronic viral hepatitis have a cost that remains high for patients despite the universal health coverage.
{"title":"Socio-economic aspects of the management of chronic viral hepatitis in Côte-d’Ivoire","authors":"H. Anzouan-Kacou, Maire Dehinsala, A. Bangoura, D. H. Kouamé, Adjéka Stanislas Doffou, A. Mahassadi, F. B. Yao, A. Attia","doi":"10.4314/aamed.v15i4.3","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.3","url":null,"abstract":"Context and objectives. Chronic viral hepatitis is a public health problem in Côte-d’Ivoire. A significant number of patients have little access to treatment due to the high costs of assessment and treatment. The objective of our study was to evaluate the costs of assessments and treatment of chronic viral hepatitis. Methods. This was an analytical cross-sectional observational study from March 1, 2019 to July 31, 2019 in the Hepato- Gastroenterology Consultation Service at the Yopougon University Hospital. The variables studied were socio-demographic and economic parameters. Results. 136 patients (men 53.6 %, average age 42 ± 12.2 years) were included. More than half of the patients (63.3 %) had a monthly income not exceeding 490.39 USD. The cost ofthe initial assessment was 223.13 USD and 351.14 USD for viral hepatitis B and C, respectively. Tenofovir and pegylated interferon were free of charge. Treatment with sofosbuvir + velpastavir cost 593.37 USD. The annual follow-up assessment was estimated at 237.02 USD for viral hepatitis B and 225.58 USD for viral hepatitis C. Conclusion. The assessment and treatment of chronic viral hepatitis have a cost that remains high for patients despite the universal health coverage.","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84019167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Philémon Matumo Mumbere, Jean Sihalikyolo Juakali, Etienne Kakule Ndungo, Olivier Mulisya, Albin Baraka Mulyanderu, L. Muhindo, A. Modia, O. L. Ahuka, G. B. Katenga
Context and objective. The sperm tests explore testicular spermatogenesis, epididymal maturation and storage, prostate and seminal vesicle secretions and genital tract patency. The aim of this study was to establish a correlation between spermogram abnormalities and epididymalvesicular biomarkers of spouses in infertile couples. Methods. An analytical cross-sectional study was conducted from November 15, 2020 to October 15, 2021 at the Centre Universitaire de Diagnostic du Graben in Butembo, DRCongo. The correlation between spermogram abnormalities and epididymal biomarkers was investigated by determining the Pearson correlation coefficient. Results. One hundred ninety-two patients were involved. The alphaglucosidase concentration was low in 31.2 % of cases of altered spermograms against 7.3 % of the spouses with normal spermograms. The fructose concentration was also low in 37.5 % of cases of altered spermograms against 4.2% of normal spermograms. Semen volume was associated with reduced fructose concentration while sperm concentration, motility, vitality and morphology were correlated with reduced alphaglucosidase levels. Chlamydia (OR: 13.7), Gonorrhoea (OR: 3.8), anti-sperm antibody serology (OR: 6.05), history of STI (OR: 3.61), smoking (OR: 5.62), leukocytospermia (OR: 6.23) as well as varicocele and obesity were significantly correlated with spermogram abnormalities. The latter were dominated by oligoasthenoteratozoospermia (39.6%) and consisted of various types of abnormalities including azoospermia (15.6 %). Conclusion. The functional status of the epididymo-vesicular and genital tract influences semen quality. Genitou-inary tract infections, even if asymptomatic, are the major etiological factor of infertility. The topographical diagnosis requires the contribution of sperm biochemical markers for a judicious therapeutic approach.
{"title":"Spermogram abnormalities correlate with epididymo-vesicular biochemical markers in infertile men: an analytical cross-sectional study","authors":"Philémon Matumo Mumbere, Jean Sihalikyolo Juakali, Etienne Kakule Ndungo, Olivier Mulisya, Albin Baraka Mulyanderu, L. Muhindo, A. Modia, O. L. Ahuka, G. B. Katenga","doi":"10.4314/aamed.v15i4.5","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.5","url":null,"abstract":"Context and objective. The sperm tests explore testicular spermatogenesis, epididymal maturation and storage, prostate and seminal vesicle secretions and genital tract patency. The aim of this study was to establish a correlation between spermogram abnormalities and epididymalvesicular biomarkers of spouses in infertile couples. Methods. An analytical cross-sectional study was conducted from November 15, 2020 to October 15, 2021 at the Centre Universitaire de Diagnostic du Graben in Butembo, DRCongo. The correlation between spermogram abnormalities and epididymal biomarkers was investigated by determining the Pearson correlation coefficient. Results. One hundred ninety-two patients were involved. The alphaglucosidase concentration was low in 31.2 % of cases of altered spermograms against 7.3 % of the spouses with normal spermograms. The fructose concentration was also low in 37.5 % of cases of altered spermograms against 4.2% of normal spermograms. Semen volume was associated with reduced fructose concentration while sperm concentration, motility, vitality and morphology were correlated with reduced alphaglucosidase levels. Chlamydia (OR: 13.7), Gonorrhoea (OR: 3.8), anti-sperm antibody serology (OR: 6.05), history of STI (OR: 3.61), smoking (OR: 5.62), leukocytospermia (OR: 6.23) as well as varicocele and obesity were significantly correlated with spermogram abnormalities. The latter were dominated by oligoasthenoteratozoospermia (39.6%) and consisted of various types of abnormalities including azoospermia (15.6 %). Conclusion. The functional status of the epididymo-vesicular and genital tract influences semen quality. Genitou-inary tract infections, even if asymptomatic, are the major etiological factor of infertility. The topographical diagnosis requires the contribution of sperm biochemical markers for a judicious therapeutic approach. ","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72603694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indretsy Mahavivola Ernestho-ghoud, Ny Ony Narindra Lova Hasina Rajaonarison, Ahmad Ahmad
Eosinophilic granulomatosis with polyangitis (EGPA), formerly known as Churg-Strauss syndrome, with antineutrophil cytoplasmic autoantibodies (ANCA) is a rare vasculitis. The CANCA is mainly antibodies to proteinase-3 and the P-ANCA is antibodies to myeloperoxidase (MPO). The EGPA with C-ANCA with antibodies anti-MPO has never been described in Subsaharan Africa. Medical investigations allowed excluding infectious diseases, malignancies and other rheumatic affections. Thus, clinical and paraclinical data suggested an atypic EGPA with MPO-C-ANCA. In our knoweledge, we reported here the first case of EGPA wtih MPO C-ANCA from Madagascar. The EGPA was succesfully controled with steroid treatment.
{"title":"Eosinophilic granulomatosis with Anti-MPO-C-ANCA-associated polyangitis: a case report illustrating the diagnosis difficulty","authors":"Indretsy Mahavivola Ernestho-ghoud, Ny Ony Narindra Lova Hasina Rajaonarison, Ahmad Ahmad","doi":"10.4314/aamed.v15i4.9","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.9","url":null,"abstract":"Eosinophilic granulomatosis with polyangitis (EGPA), formerly known as Churg-Strauss syndrome, with antineutrophil cytoplasmic autoantibodies (ANCA) is a rare vasculitis. The CANCA is mainly antibodies to proteinase-3 and the P-ANCA is antibodies to myeloperoxidase (MPO). The EGPA with C-ANCA with antibodies anti-MPO has never been described in Subsaharan Africa. Medical investigations allowed excluding infectious diseases, malignancies and other rheumatic affections. Thus, clinical and paraclinical data suggested an atypic EGPA with MPO-C-ANCA. In our knoweledge, we reported here the first case of EGPA wtih MPO C-ANCA from Madagascar. The EGPA was succesfully controled with steroid treatment.","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75512759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ángeles Leyda Avilés García, Eliezer Morales Rojas, M. Piña, H. Zerón
The COVID-19 pandemic has caused problems in the health and social fields, seriously affecting the perception of health personnel by the general population. A systematic review of scientific articles has been carried out in databases such as Pubmed, Scielo, Latindex and Google Scholar, and in Google, since the first case of COVID-19 reported in Mexico on February 28 2020 through April 2021. During the study period, two articles were found in the Pubmed, one article was published in each of the other databases, and eight more through Google. In Mexico, the State of Jalisco is the federal entity with the highest number of reported attacks on health care personnel relative to its population.
{"title":"Violence against health personnel in Mexico in the context of the COVID-19 pandemic: a systematic review","authors":"Ángeles Leyda Avilés García, Eliezer Morales Rojas, M. Piña, H. Zerón","doi":"10.4314/aamed.v15i4.8","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.8","url":null,"abstract":"The COVID-19 pandemic has caused problems in the health and social fields, seriously affecting the perception of health personnel by the general population. A systematic review of scientific articles has been carried out in databases such as Pubmed, Scielo, Latindex and Google Scholar, and in Google, since the first case of COVID-19 reported in Mexico on February 28 2020 through April 2021. During the study period, two articles were found in the Pubmed, one article was published in each of the other databases, and eight more through Google. In Mexico, the State of Jalisco is the federal entity with the highest number of reported attacks on health care personnel relative to its population.","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76553613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taoufik Elabbassi, Abdeladime Zouhair, A. Elkarouachi, Bachar Amine, M. Lefriyekh
Spiegel's hernia, also known as lateral ventral hernia, is a rare entity of abdominal hernias due to a congenital or acquired defect in the abdominal wall anterior to the midline. The incidence is approximately 2% of abdominal wall hernias. It most commonly affects the elderly, and is more common in women. This hernia is secondary to certain factors such as collagen disorders, obesity, pregnancy, chronic cough. Diagnosis is often difficult due to its particular location, usually asymptomatic, but the risk of strangulation is significant. Abdominal ultrasound is useful, but a computerized tomography (CT) scan is the best imaging test to confirm the diagnosis with a highr sensitivity, allowing visualization of the muscle dehiscence and the content of the hernia sac. We report a case of an unstrangulated Spiegel’s hernia in an elderly man, treated surgically with a composite mesch under laparoscopy.
{"title":"Spiegel's hernia, a rare weakness of the abdominal wall","authors":"Taoufik Elabbassi, Abdeladime Zouhair, A. Elkarouachi, Bachar Amine, M. Lefriyekh","doi":"10.4314/aamed.v15i4.12","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.12","url":null,"abstract":"Spiegel's hernia, also known as lateral ventral hernia, is a rare entity of abdominal hernias due to a congenital or acquired defect in the abdominal wall anterior to the midline. The incidence is approximately 2% of abdominal wall hernias. It most commonly affects the elderly, and is more common in women. This hernia is secondary to certain factors such as collagen disorders, obesity, pregnancy, chronic cough. Diagnosis is often difficult due to its particular location, usually asymptomatic, but the risk of strangulation is significant. Abdominal ultrasound is useful, but a computerized tomography (CT) scan is the best imaging test to confirm the diagnosis with a highr sensitivity, allowing visualization of the muscle dehiscence and the content of the hernia sac. We report a case of an unstrangulated Spiegel’s hernia in an elderly man, treated surgically with a composite mesch under laparoscopy. ","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85015899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osteoma is a benign osteogenic lesion with slow and insidious growth rarely observed in the mandible. We report a new and rarely described localization of a peripheral osteoma of unusual size, while showing the interest of piezosurgery in the conservative excision. This technique is less aggressive without morpho-functional sequelae. However, it is important to perform an adequate maxillofacial examination and a correct radiological reading in order to detect this type of lesion early. The diagnostic certainty is always histological.
{"title":"A peripheral osteoma of the mandible: a case report","authors":"I. Turki","doi":"10.4314/aamed.v15i4.10","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.10","url":null,"abstract":"Osteoma is a benign osteogenic lesion with slow and insidious growth rarely observed in the mandible. We report a new and rarely described localization of a peripheral osteoma of unusual size, while showing the interest of piezosurgery in the conservative excision. This technique is less aggressive without morpho-functional sequelae. However, it is important to perform an adequate maxillofacial examination and a correct radiological reading in order to detect this type of lesion early. The diagnostic certainty is always histological.","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82458018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. M. Pamatika, C. D. Mossoro-Kpinde, Aint-Calvaire Henri Dieme, Geoffroy Ndakouzou Kongo, Régina Edwige Lenguetama Kodia, Hyacinthe Nguida, J. D. D. Longo
Context and objective. Viral hepatitis B (VHB) by its evolution can lead to recovery or to a chronic form. This chronic form, a source of new contaminations, is not documented among voluntary blood donors (VBD) in Bangui and Bimbo. The present study aimed to determine the prevalence of chronic VHB among VBD in the two cities in the Central African Republic (CAR). Methods. The study carried out at the Bangui National Blood Transfusion Center was retrospective and focused on serological control data from VBD from Bangui, capital of CAR and Bimbo. The exhaustive sampling is from July 2013 to December 2019. A VBD carries a chronic infection if the VHB surface antigen persists for more than six months. Results. Serological control data from 702 VBD aged 18 to 62 years were analyzed. Male sex predominated at inclusion (n = 598). The prevalence of chronic VHB was 70.5 %. This prevalence was higher among young VBD aged 25 to 34 years (30.4 %), the male gender (58.4 %) and VBD residing in Bangui (61.2 %). The chronic form was significantly associated with young age (18 to 44 years) and male sex (p< 5%). Co-infection with HIV and hepatitis C was found in 5.5 % of cases (39/702). Conclusion. The prevalence of chronic VHB is very high in VBD from Bangui and Bimbo. The chronic form was significantly associated with age and sex. Free viral load and antiviral treatment are prospects to be implemented.
{"title":"Prevalence of chronic viral hepatitis B in Bangui and Bimbo in the Central African Republic: cases of regular voluntary donors not eligible for blood donations","authors":"C. M. Pamatika, C. D. Mossoro-Kpinde, Aint-Calvaire Henri Dieme, Geoffroy Ndakouzou Kongo, Régina Edwige Lenguetama Kodia, Hyacinthe Nguida, J. D. D. Longo","doi":"10.4314/aamed.v15i4.7","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.7","url":null,"abstract":"Context and objective. Viral hepatitis B (VHB) by its evolution can lead to recovery or to a chronic form. This chronic form, a source of new contaminations, is not documented among voluntary blood donors (VBD) in Bangui and Bimbo. The present study aimed to determine the prevalence of chronic VHB among VBD in the two cities in the Central African Republic (CAR). Methods. The study carried out at the Bangui National Blood Transfusion Center was retrospective and focused on serological control data from VBD from Bangui, capital of CAR and Bimbo. The exhaustive sampling is from July 2013 to December 2019. A VBD carries a chronic infection if the VHB surface antigen persists for more than six months. Results. Serological control data from 702 VBD aged 18 to 62 years were analyzed. Male sex predominated at inclusion (n = 598). The prevalence of chronic VHB was 70.5 %. This prevalence was higher among young VBD aged 25 to 34 years (30.4 %), the male gender (58.4 %) and VBD residing in Bangui (61.2 %). The chronic form was significantly associated with young age (18 to 44 years) and male sex (p< 5%). Co-infection with HIV and hepatitis C was found in 5.5 % of cases (39/702). Conclusion. The prevalence of chronic VHB is very high in VBD from Bangui and Bimbo. The chronic form was significantly associated with age and sex. Free viral load and antiviral treatment are prospects to be implemented.","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88116846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Loua, Dramane Ouedraogo, Dramane Ouadraogo, M. Soumaré, Amayi Essénam Allé Akapko, Y. Cissoko
Cerebral toxoplasmosis and tuberculosis miliaria are major and serious opportunistic infections, usually occurring in HIV-positive individuals with CD4 counts< 200 cells/mm3. We report here a case in a 56-year-old patient with toxoplasmosistuberculosis- HIV co-infection with CD4 count of 446 cells/mm3. Under multidrug therapy (cotrimoxazole and first-line antituberculosis drugs), the favorable evolution (clinical improvement) was observed on the fourteenth day of cotrimoxazole treatment. High antiretroviral therapy (HAART) was reintroduced on the fifteenth day of anti-tuberculosis treatment, after two sessions of psychotherapy. Through this clinical case, the practitioner should be warned about the possibility of concomitant opportunistic infections in an HIV immunocompromised patient, especially without chemoprophylaxis, whatever his CD4 count.
{"title":"Cerebral toxoplasmosis, miliary tuberculosis and HIV co-infection with CD4 count of 446 cells/mm3: an unsual case report","authors":"O. Loua, Dramane Ouedraogo, Dramane Ouadraogo, M. Soumaré, Amayi Essénam Allé Akapko, Y. Cissoko","doi":"10.4314/aamed.v15i4.11","DOIUrl":"https://doi.org/10.4314/aamed.v15i4.11","url":null,"abstract":"Cerebral toxoplasmosis and tuberculosis miliaria are major and serious opportunistic infections, usually occurring in HIV-positive individuals with CD4 counts< 200 cells/mm3. We report here a case in a 56-year-old patient with toxoplasmosistuberculosis- HIV co-infection with CD4 count of 446 cells/mm3. Under multidrug therapy (cotrimoxazole and first-line antituberculosis drugs), the favorable evolution (clinical improvement) was observed on the fourteenth day of cotrimoxazole treatment. High antiretroviral therapy (HAART) was reintroduced on the fifteenth day of anti-tuberculosis treatment, after two sessions of psychotherapy. Through this clinical case, the practitioner should be warned about the possibility of concomitant opportunistic infections in an HIV immunocompromised patient, especially without chemoprophylaxis, whatever his CD4 count. ","PeriodicalId":31055,"journal":{"name":"Annales Africaines de Medecine","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80598965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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