Environmental Pollution最新文献

{"title":"A case-control study linking concentrations of microplastics in human cerebrospinal fluid to intracranial aneurysm risk","authors":"Zebin Fang ,&nbsp;Xiaoyi Wang ,&nbsp;Fan Wu ,&nbsp;Sihan Mao ,&nbsp;Hao Jiang ,&nbsp;Chi Hu ,&nbsp;Luyuan Zhang ,&nbsp;Weijian Fan ,&nbsp;Chao Zhang ,&nbsp;Ping Lan ,&nbsp;Kaiyuan Huang ,&nbsp;Yuxiang Weng ,&nbsp;Jianwei Pan","doi":"10.1016/j.envpol.2026.127788","DOIUrl":"10.1016/j.envpol.2026.127788","url":null,"abstract":"<div><div>Microplastics (MPs) have become a global concern due to their widespread environmental presence and human health risk, yet their risk on cerebrovascular diseases remains largely unexplored. In this case-control study, we collected cerebrospinal fluid samples from 48 intracranial aneurysms (IAs) patients and 108 leptomeningeal metastasis (LM) patients, and investigated the presence of MPs in these cerebrospinal fluid samples using pyrolysis-gas chromatography-mass spectrometry. Seven types of MPs were identified in the cerebrospinal fluid samples, among which polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polystyrene were present in over 80% of the samples. PE and PP were the most abundant MPs in cerebrospinal fluid samples. When using LM patients as controls, a significantly increased risk of IA was observed for subjects in the highest quartile of cerebrospinal fluid PP and PVC levels. Compared to the lowest quartile, the adjusted risk was elevated by 2.25-fold (95% CI: 1.68–5.94) and 3.82-fold (95% CI: 2.57–5.41) for PP and PVC levels, respectively. Our analysis revealed significant (<em>p</em> for trend &lt;0.01) dose-response relationships between cerebrospinal fluid MP mixture concentrations and IA risk. Bayesian kernel machine regression and quantile g-computation models further revealed synergistic effects of co-occurrence to MPs, with PVC contributing the strongest contribution (weight 55.8%). Our results suggest a potential link between higher cerebrospinal fluid levels of MPs and elevated IA risk, and highlight the need for further investigation into this emerging health risk.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127788"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polylactic acid microplastic exposure induced male reproductive toxicity and decreased testosterone levels by accelerating Leydig cell senescence","authors":"Zhencheng Fan ,&nbsp;Xinglong Wang ,&nbsp;Yunqi Wu ,&nbsp;Shuhao Li ,&nbsp;Liang Kong ,&nbsp;Shoujun Li ,&nbsp;Tan Ma ,&nbsp;Chun Pan","doi":"10.1016/j.envpol.2026.127778","DOIUrl":"10.1016/j.envpol.2026.127778","url":null,"abstract":"<div><div>Polylactic acid microplastics (PLA-MPs), despite being marketed as biodegradable and eco-friendly alternatives to conventional plastics, have raised growing concerns regarding their potential adverse effects on human health. The reproductive toxicity of PLA-MPs exposure in male mammals has been confirmed in previous studies, but its specific effects on testosterone biosynthesis remain unclear. Male mice were treated with PLA-MPs at doses of low, medium, and high (0.01, 0.1, and 1 mg/d, respectively) for a duration of 28 days in this study. Our results demonstrated that PLA-MPs were enriched in mouse testes and led to a dose-dependent decrease in the serum testosterone concentration. We also observed the accumulation of senescent Leydig cells in the testis, along with inhibited autophagy and mitophagy. Moreover, we identified the critical involvement of autophagy and mitophagy in PLA-MPs-induced Leydig cell senescence. Re-establishment of autophagy and mitophagy effectively reserved the senescence of Leydig cell. Overall, our study revealed that PLA-MPs inhibit autophagy and mitophagy, thereby promoting Leydig cell senescence and subsequently reducing testosterone synthesis and secretion. These results advance our understanding of the pathogenic mechanisms underlying PLA-MPs-induced reproductive toxicity in male mammals.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127778"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the association between early-pregnancy hair metal levels and gestational diabetes mellitus","authors":"Feng Tang ,&nbsp;Jun Guo ,&nbsp;Li-An-Sheng Wu ,&nbsp;Xiao-Yuan Fan ,&nbsp;Han-Wen Zhang ,&nbsp;Noora Kartiosuo ,&nbsp;Boris Novakovic ,&nbsp;Ting-Li Han ,&nbsp;Hua Zhang ,&nbsp;Yin-Yin Xia ,&nbsp;Philip Baker ,&nbsp;Richard Saffery","doi":"10.1016/j.envpol.2026.127765","DOIUrl":"10.1016/j.envpol.2026.127765","url":null,"abstract":"<div><div>Gestational diabetes mellitus (GDM) is a common complication of pregnancy with a complex etiology, and environmental exposure to metals is considered a potential and important risk factor. However, there is still insufficient research on the comprehensive effects of long-term mixed exposure to multiple metals during early pregnancy on GDM and the potential mediating factors. This study aimed to systematically explore the independent and combined effects of exposure to 15 metals during early pregnancy on GDM risk and to clarify the potential mediating role of saturated fatty acids (SFAs) through a prospective cohort of 665 pregnant women recruited between September 2015 and June 2017. Hair samples were collected during early pregnancy, and metal concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS). SFAs levels in mid-pregnancy were measured by gas chromatography-mass spectrometry (GC-MS). Statistically, logistic regression and restricted cubic splines (RCS) were used to assess the effects of individual metals, and Weighted Quantile Sum (WQS) and Bayesian kernel machine regression(BKMR) model were applied to analyze the combined effects of metal mixtures. Additionally, mediation analysis was conducted to investigate the mediating roles of three SFAs. The results showed that potassium (K), rubidium (Rb), niobium (Nb), silver (Ag), and thallium (Tl) were positively associated with GDM risk, while Nb, Ag, and mercury (Hg) exhibited non-linear exposure-response relationships. Metals mixture had an overall possitive effect on GDM risk. Mediation analysis revealed that myristic acid (C14:0) mediated the associations of K, Rb, Nb, and Ag with GDM risk; pentadecanoic acid (C15:0) mediated the associations of K, Rb, and Nb with GDM risk; and heptadecanoic acid (C17:0) mediated the associations of Rb and Ag with GDM risk.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127765"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioaccumulation, trophic transfer, and health risk assessment of microplastics in the food web of Wuliangsuhai Lake, China: Higher risk for children","authors":"Guoliang Zhang ,&nbsp;Jinhui Sun ,&nbsp;Yiran Zhan ,&nbsp;Bowen Xiao ,&nbsp;Huamin Liu ,&nbsp;Lixin Wang","doi":"10.1016/j.envpol.2026.127787","DOIUrl":"10.1016/j.envpol.2026.127787","url":null,"abstract":"<div><div>Microplastics (MPs) are widely ingested by aquatic organisms. Thus far, our understanding of the biomagnification potential and health risks of MPs in lake ecosystems remains unclear. Herein, we investigated the pollution levels and characteristics of MPs in surface water, sediment, and aquatic organisms from Wuliangsuhai Lake, China. Food web structure was determined by stable isotope analysis, then the biomagnification potential and associated human health risks of MPs were assessed. The dominant shape of MPs in Wuliangsuhai Lake was fiber, with particle sizes mainly less than 0.5 mm, the primary colors were transparent and blue, and the main polymer types were polyethylene terephthalate (PET), polyethylene (PE), and polypropylene (PP). MP concentrations in organisms decreased with the increasing body size, and the concentration of MPs in omnivorous organisms was significantly higher than that in organisms with other feeding strategies. A significant negative correlation was observed between the trophic level of organisms and their MP concentration, indicating that biodilution of MPs occurred in the food web. PP exhibited a higher biodilution effect while PET showed a lower biodilution effect. MPs were accumulated in the edible tissues (e.g., muscle) of aquatic organisms, indicating the human health risk via the dietary route of consuming MP-contaminated aquatic products. Notably, the estimated daily intake (EDI) of MPs for children was higher than that for adults, highlighting the greater health risks for children. This study provided new insights into the trophic transfer and the associated health risks of MPs in lake ecosystems. Future research should investigate the trophic transfer of nanoplastics along the food web to assess their potential risks to human health.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127787"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plastic debris facilitates the survival of multidrug-resistant bacterial pathogens in an urban agricultural environment","authors":"Michael J. Ormsby ,&nbsp;Luke Woodford ,&nbsp;James J. Mwesiga ,&nbsp;Winnie Ernest ,&nbsp;Dativa Shilla ,&nbsp;Daniel Shilla ,&nbsp;Richard S. Quilliam","doi":"10.1016/j.envpol.2026.127786","DOIUrl":"10.1016/j.envpol.2026.127786","url":null,"abstract":"<div><div>Rapid urbanisation in Low- and Middle-Income Countries (LMICs) has driven the expansion of urban and peri-urban farming to enhance food security. However, these systems are highly vulnerable to contaminated irrigation waters, urban runoff, open defecation and inadequate sanitation, and anthropogenic pollution, such as plastic and microplastic waste. Here, we investigated the role of plastic debris as a reservoir and vector for multidrug-resistant (MDR) enteric bacterial pathogens in a real-world agronomic setting. Focusing on two peri-urban agricultural sites in Dar es Salaam, Tanzania, we analysed 140 environmental samples (soil, water, vegetation, and surface and buried plastic debris) for the presence of four key enteric pathogens: <em>E. coli</em>, <em>Salmonella</em> spp., <em>V. cholerae</em>, and <em>K. pneumoniae</em>. The concentration of total culturable pathogens was higher on plastic debris compared to soil, water and vegetation, with presumptive <em>E. coli</em> loads of ∼1 × 10³ CFU per individual piece of plastic debris. Importantly, plastic debris harboured a greater proportion of MDR strains; specifically, 69% of <em>E. coli</em> isolates were resistant to two or more antimicrobials, with plastics at one site accounting for over half of all MDR <em>E. coli</em>. While MDR <em>E. coli</em> were absent from soil, plastic debris supported strains of <em>E. coli</em> and <em>K. pneumoniae</em> that were resistant to critically important antimicrobials (e.g., ciprofloxacin and cefixime).This study provides robust evidence that in a real-world setting, plastic waste can act as an ecological reservoir which concentrates and facilitates the survival of MDR pathogens. Therefore, the widespread presence of contaminated plastic in agricultural systems could pose significant occupational health risks for farmers, in addition to a potential environment-to-food risk for consumers.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127786"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of HECAM passive samplers for discovering the occurrence, sources, and transport of tire additives and their transformation products in surface waters","authors":"Ran Zhu ,&nbsp;Yuchen Li ,&nbsp;Xiaofan Yang ,&nbsp;Xiaozhong Gao ,&nbsp;Xiang Cheng","doi":"10.1016/j.envpol.2026.127789","DOIUrl":"10.1016/j.envpol.2026.127789","url":null,"abstract":"<div><div>Tire additives and their transformation products (TATPs) such as <em>p</em>-phenylenediamines (PPDs), PPDs-derived quinones (PPDQs), and other industrial additives have been highly concerned emerging contaminants in recent years. The hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane (HECAM) is a highly sensitive and efficient passive sampler designed to simultaneously monitor hydrophilic and hydrophobic contaminants in waters. This work evaluated passive sampling performance of twelve TATPs in the HECAM, and a field application was conducted for discovering occurrence, sources, and transport of TATPs in northeast China (Hinggan League, Inner Mongolia). In the laboratorial experiments, the uptake of twelve TATPs in HECAM well followed a first-order kinetic model. Chemical structures of TATPs affect their accumulation and TATPs with moderate polarities have relatively higher equilibrium partition coefficients. In the field sampling, nine TATPs were detected with concentrations ranging from 0.06 ng L⁻¹ to 423 ng L⁻¹. Azoles have much higher levels than PPDs and PPDQs, and all TATPs would transport with runoffs and rivers. As reported data in water of remote northeast China, the PPDs and PPDQs concentrations were much lower than those of south China, which could be related to the low population density (traffic activities) and intense photodegradation in Inner Mongolia. In this area, both human settlements and fungicides use are important sources of the azoles, and they would transport to nearby rivers by the farmland runoffs. This work indicated that HECAM shows potential as a highly efficient sampler for comprehensive monitoring TATPs in surface waters.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127789"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polystyrene nanoplastics exacerbate dibutyl phthalate-induced liver fibrosis through PDGFRα-dependent hepatic stellate cell activation","authors":"Eun Bok Baek ,&nbsp;Jae-Hong Ko ,&nbsp;Hisao Yamamura ,&nbsp;Aya Yamamura ,&nbsp;Hyang-Ae Lee ,&nbsp;Eun-Jin Kim ,&nbsp;Anjas Happy Prayoga ,&nbsp;Ahmad Awwalun Nashar ,&nbsp;Jae-Ho Lee ,&nbsp;Sung-Cherl Jung ,&nbsp;Tong Zhou ,&nbsp;Dawon Kang ,&nbsp;Eun-A Ko","doi":"10.1016/j.envpol.2026.127763","DOIUrl":"10.1016/j.envpol.2026.127763","url":null,"abstract":"<div><div>Nanoplastic particles (NPs) derived from common polymers such as polyvinyl chloride and polystyrene (PS) act as persistent environmental reservoirs that facilitate the transport and cellular internalization of dibutyl phthalate (DBP), a ubiquitous plasticizer contaminating air, water, soil, and food through plastic leaching. The platelet-derived growth factor receptor α (PDGFRα) pathway is a well-established regulator of hepatic stellate cell (HSC) activation and fibrogenesis; however, its mechanistic involvement in plastic particle–induced hepatotoxicity and its intersection with DBP-mediated fibrosis remain unclear. Using HSC-hepatic cell cocultures (LX-2-HepG2 or LO2) and transcriptomic profiling, we demonstrate that DBP exposure markedly decreases hepatic cellular viability, elevates proinflammatory cytokines (TNF and IL-6), and induces apoptosis. In parallel, DBP stimulates LX-2 proliferation and upregulates fibrogenic markers (<em>TGFB1, COL1A1, ACTA2</em>) along with enhanced secretion of PDGF-A and PDGF-B, thereby reinforcing hepatic cell injury through paracrine signaling. RNA-seq analysis revealed activation of apoptotic and TNF-related pathways in LO2, whereas LX-2 cells exhibited upregulation of oncogenic and PI3K–Akt signaling, collectively promoting a profibrotic transcriptional landscape. In vivo, both PDGFRα antibody neutralization and pharmacological inhibition with imatinib significantly attenuated DBP-induced hepatic fibrosis and inflammatory gene expression, confirming PDGFRα′s central role in DBP toxicity. Polystyrene nanoplastics (PS-NPs) were rapidly internalized by PDGFRα-positive primary HSCs within 24 h, leading to increased PDGFRα and PI3K expression. Co-exposure to PS-NPs and DBP resulted in synergistic hepatotoxicity and exacerbated fibrotic injury, demonstrating compounding effects of mixed environmental pollutants. Collectively, these findings identify PDGFRα as a mechanistic nexus linking DBP and PS-NPs exposure to hepatic fibrosis and highlight its potential as a therapeutic target for environmentally induced liver disease. The results further underscore the importance of co-exposure paradigms in evaluating the health risks of complex contaminant mixtures.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127763"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urban runoff impacts on benthic communities of a receiving stream","authors":"Neus Besolí-Mestres ,&nbsp;Mar Auró ,&nbsp;Sílvia Gómez-Arcusa ,&nbsp;Itxaso Martinez-Sanz ,&nbsp;M. Isabel Cadena-Aizaga ,&nbsp;Núria de Castro-Català ,&nbsp;Isabel Muñoz ,&nbsp;Mira Petrovic ,&nbsp;Sergi Sabater ,&nbsp;Anna Freixa","doi":"10.1016/j.envpol.2026.127808","DOIUrl":"10.1016/j.envpol.2026.127808","url":null,"abstract":"<div><div>Chemical pollutants are mobilized during rainfall episodes in urban and industrial areas. As a result, complex mixtures of pollutants may enter freshwater ecosystems, potentially exacerbating the individual pollutant effects on aquatic organisms and on ecosystems functioning. We investigated the ecological impacts of five runoff episodes on an urban stream (Girona, Spain) by assessing the effects on the structure and function of river biofilms, and on the community composition of macroinvertebrate assemblages. Each of the five rainfall events was evaluated independently using a Control (upstream) vs Impact (downstream of the urban runoff entrance) design. Urban runoff transported high concentrations of dissolved organic carbon, and a suite of organic (1,3-diphenylguanidine) and inorganic pollutants (zinc, copper). These added to other pollutants which were already present in the urban stream. Small-scale flood events following rainfall episodes caused biofilm detachment, confounding the effects of hydrological disturbance with those of urban runoff pollutants. Urban runoff caused peaks in nutrient, DOC and pollutant concentrations, consistently adding to an increase in chlorophyll-a content, phosphatase activity and bacterial densities in river biofilms. Macroinvertebrate composition variations mostly reflected temporal dynamics. Overall, pollutant impacts associated with urban runoff became masked by environmental factors, and effects on biofilm communities were most evident after events of moderate rainfall, which allowed pollutant-driven responses to emerge. These findings indicate that recurrent urban runoff episodes can increase ecological risks in urban streams, particularly under scenarios of increasing urbanisation and climate-driven extremes.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127808"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological risks and recent inputs of banned and current-use pesticides in surface water and sediment from Malawi's tobacco-growing region","authors":"Emmanuel Cishibanji ,&nbsp;Rodgers Makwinja ,&nbsp;Elias Chirwa ,&nbsp;Benjamin N. Kondowe ,&nbsp;John Kamanula ,&nbsp;Christopher J. Curtis ,&nbsp;Fabrice Muvundja ,&nbsp;Bossissi Nkuba","doi":"10.1016/j.envpol.2026.127772","DOIUrl":"10.1016/j.envpol.2026.127772","url":null,"abstract":"<div><div>Pesticides play a key role in conventional agriculture and food security. However, their heavy use poses human and environmental risks. In this study, we employed the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method, followed by gas or liquid chromatography-tandem mass spectrometry, to quantify pesticide residues commonly associated with tobacco farming and to assess their ecological risks in river systems. We detected residues of banned and currently registered pesticides in water and sediment. Pyrethroid residues were higher, with concentrations of 7.62–15.2 μg/L in water and 0.51–8.71 μg/kg in sediment (α-cypermethrin). Organophosphates ranged from 0.94 to 13.3 μg/L in water and 0.08–5.37 μg/kg in sediment (chlorpyrifos-methyl); organochlorines from 0.11 μg/L (γ-HCH) to 10.8 μg/L (o,p'-DDT) in water and 0.08 μg/kg (p,p'-DDT) to 5.48 μg/kg (α-HCH) in sediment; and neonicotinoids from 0.02 to 4.19 μg/L in water and 0.03–4.52 μg/kg in sediment (imidacloprid). Seasonality and water quality had weak effects on most pesticide levels (95% credible intervals). Degradation and isomer profiles indicated recent inputs of DDT and HCH. Except for neonicotinoids, all detected pesticides in water posed considerable ecological risks (RQ &gt; 1), and their mixtures could cause acute harm to algae, invertebrates, and fish (STU &gt;1). In contrast, neonicotinoids in porewater primarily threatened sediment-dwelling organisms (RQ &gt; 1), particularly <em>Chironomus</em> spp. This study provides critical evidence of ecological risks posed by tobacco pesticides in aquatic ecosystems. We recommend regular pesticide monitoring to safeguard river health and guide ecological management in tobacco-producing regions. Promoting safer pesticide use is strongly encouraged.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127772"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of nitrate on uptake and translocation of organophosphate esters in wheat (Triticum aestivum L.)","authors":"Shuaihao Liu ,&nbsp;Hongyi Xue ,&nbsp;Guoguang Wang ,&nbsp;Yana Wang ,&nbsp;Jiameng Hou ,&nbsp;Jingya Zhang ,&nbsp;Haixia Wang ,&nbsp;Yu Liu","doi":"10.1016/j.envpol.2026.127807","DOIUrl":"10.1016/j.envpol.2026.127807","url":null,"abstract":"<div><div>Tris(2-chloroethyl) phosphate (TCEP) and tributyl phosphate (TnBP) are the typical organophosphate esters (OPEs), and detected in high concentrations and frequencies in environment. Nitrate, as an essential plant nutrient, can regulate the environmental behaviors and fates of pollutants within plants. However, the underlying mechanisms of mediation of nitrate on environmental behaviors of OPEs in plants remained unclear. This study integrated compound-specific stable isotope analysis, transcriptomics, and molecular docking simulations to systematically investigate the effects of nitrate on the uptake and translocation of TCEP and TnBP in wheat. Results showed that nitrate with low (LN, 40 mg/L NaNO₃) and high levels (HN, 100 mg/L NaNO₃) significantly inhibited the root uptake and translocation to shoots of TCEP and TnBP, with the higher inhibition effects for LN than HN. Compound-specific stable isotope analysis revealed that nitrate reduced TCEP uptake via aquaporins in wheat roots, specifically inhibiting the transmembrane transport of TCEP molecules with heavy carbon isotopes. Transcriptomic and molecular docking simulations consistently demonstrated that the nitrate-specific transporters of SLAH2 and NRT1 were involved in mediating the transmembrane transport of TCEP, and nitrate inhibited TCEP transport via the downregulation of gene expression of SLAH2 and NRT1 and competitive binding to active sites of these two transporters with TCEP. Overall, this study clarified that nitrate could effectively suppress the root uptake of TCEP and TnBP in wheat, providing a basis for developing application of nitrate to mitigate OPE contamination in crops.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"395 ","pages":"Article 127807"},"PeriodicalIF":7.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}