Pub Date : 2025-12-06DOI: 10.1016/j.envpol.2025.127503
Wen-Peng Zhao, Shi-Quan Zhu, Zhi-Hong Yin, Mohammad Mehdi Ommati, Ya-Wen Zhang, Jing Zhao, Bian-Hua Zhou, Hong-Wei Wang
Neuroinflammation is a hallmark of central nervous system injury caused by fluorosis; however, the regulatory relationship between intestinal microbial and fluoride-induced neuroinflammation remains unclear. Here, we aimed to evaluate the alleviating effect of short-chain fatty acids (SCFAs) on fluorine exposure-induced neuroinflammation in rats. In this study, it is demonstrated that the composition of colonic microbiota was disrupted in fluoride-exposed rats at both phylum and genus levels, and fluoride exposure decreased the number of goblet cells, inhibited mucin secretion, and reduced the protein expression of MUC2 and TFF3, and tight junction proteins (Occludin and ZO-1) in the colon tissue, leading to colonic mucosal barrier damage. Additionally, the content of IL-1β, TNF-α and LPS in the serum of fluoride-exposed rats was increased, and the TLR4/NF-κB pathway was also activated in the colon tissue. Moreover, the expression of Occludin and ZO-1 in the cerebral cortex was decreased by fluoride exposure, resulting in neuronal damage, astrocyte and microglial activation and the activation of the TLR4/NF-κB signaling pathway, which subsequently induced neuroinflammation. However, these adverse effects were mitigated by supplementation with SCFAs. It was observed that supplementation with SCFAs improves microbial dysbiosis in the colon, and SCFAs enhance tight junction integrity between intestinal epithelial cells, decrease intestinal permeability and the content of IL-1β, TNF-α and LPS in the serum, inhibit colonic inflammation. Additionally, SCFAs restored the damaged blood-brain barrier structure, suppressed astrocyte and microglial activation, and relieved fluoride-induced neuroinflammation by inhibiting the activation of the TLR4/NF-κB signaling pathway. In conclusion, SCFAs supplementation alleviates fluoride-induced colonic barrier damage and microbial disturbances, thereby mitigating fluoride-induced neuroinflammation in rats through the microbiota-gut-brain axis.
{"title":"Short-chain fatty acids alleviated fluoride-induced neuroinflammation via the gut-brain axis in rats","authors":"Wen-Peng Zhao, Shi-Quan Zhu, Zhi-Hong Yin, Mohammad Mehdi Ommati, Ya-Wen Zhang, Jing Zhao, Bian-Hua Zhou, Hong-Wei Wang","doi":"10.1016/j.envpol.2025.127503","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127503","url":null,"abstract":"Neuroinflammation is a hallmark of central nervous system injury caused by fluorosis; however, the regulatory relationship between intestinal microbial and fluoride-induced neuroinflammation remains unclear. Here, we aimed to evaluate the alleviating effect of short-chain fatty acids (SCFAs) on fluorine exposure-induced neuroinflammation in rats. In this study, it is demonstrated that the composition of colonic microbiota was disrupted in fluoride-exposed rats at both phylum and genus levels, and fluoride exposure decreased the number of goblet cells, inhibited mucin secretion, and reduced the protein expression of MUC2 and TFF3, and tight junction proteins (Occludin and ZO-1) in the colon tissue, leading to colonic mucosal barrier damage. Additionally, the content of IL-1β, TNF-α and LPS in the serum of fluoride-exposed rats was increased, and the TLR4/NF-κB pathway was also activated in the colon tissue. Moreover, the expression of Occludin and ZO-1 in the cerebral cortex was decreased by fluoride exposure, resulting in neuronal damage, astrocyte and microglial activation and the activation of the TLR4/NF-κB signaling pathway, which subsequently induced neuroinflammation. However, these adverse effects were mitigated by supplementation with SCFAs. It was observed that supplementation with SCFAs improves microbial dysbiosis in the colon, and SCFAs enhance tight junction integrity between intestinal epithelial cells, decrease intestinal permeability and the content of IL-1β, TNF-α and LPS in the serum, inhibit colonic inflammation. Additionally, SCFAs restored the damaged blood-brain barrier structure, suppressed astrocyte and microglial activation, and relieved fluoride-induced neuroinflammation by inhibiting the activation of the TLR4/NF-κB signaling pathway. In conclusion, SCFAs supplementation alleviates fluoride-induced colonic barrier damage and microbial disturbances, thereby mitigating fluoride-induced neuroinflammation in rats through the microbiota-gut-brain axis.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"55 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1016/j.envpol.2025.127505
Rahini Mahendran, Lei Zhang, Rongbin Xu, Tingting Ye, Yiwen Zhang, Zhihu Xu, Wenzhong Huang, Zhengyu Yang, Micheline SZS Coelho, Paulo H.N. Saldiva, Shanshan Li, Yuming Guo
Wildfire fine particulate matter (PM2.5) is an emerging health concern, yet its effects on mosquito-borne diseases, particularly dengue, remain unclear. Brazil faces one of the world’s highest dengue burdens alongside frequent wildfires. We examined the association between short-term wildfire-specific PM2.5 exposure and dengue-related hospitalizations across Brazil. We conducted a nationwide two-stage time-series analysis using daily dengue-related hospitalizations and daily wildfire-specific PM2.5 concentrations across all Brazilian immediate-regions from 2008–2019. The wildfire-specific PM2.5 estimates were derived from a chemical transport model and machine-learning calibration. Immediate region-specific associations between wildfire-specific PM2.5 with dengue hospitalization risks were estimated using quasi-Poisson regression with distributed lag models and pooled using random-effects meta-analysis. Effect modification by socio-demographic factors, season, and forest cover was examined and attributable dengue hospitalizations were estimated. A 5 μg/m3 increase in wildfire-specific PM2.5 (lag 0–7 days) was associated with a 10.5% increase in dengue-related hospitalizations (Relative risk [RR]: 1.105 (95% Confidence Interval [CI]: 1.060–1.152), stronger for dengue fever (RR: 1.094, 95%CI: 1.049–1.141) than for Dengue Hemorrhagic Fever (DHF) (1.174, 0.754–1.831). Associations were consistent across sex, age groups, and regions, with higher risks in the elderly for DHF. Risks were greater during the dry season and in less densely populated areas. An estimated 28,994 dengue-related hospitalizations (95% CI: 16,737–40,867) were attributable to wildfire-specific PM2.5 exposure in Brazil, averaging 17.3 per 100,000 population annually. The Northeast region had the highest number of attributable dengue-related hospitalizations, while the Southeast region had higher population-level impact. No association was found with non-wildfire PM2.5. Wildfire-specific PM2.5 exposure increases dengue-related hospitalization risk in Brazil, underscoring the need to integrate wildfire smoke into dengue and vector surveillance and to target high-risk areas to reduce disease burden.
{"title":"Wildfire smoke and dengue burden in Brazil: Evidence from a nationwide study","authors":"Rahini Mahendran, Lei Zhang, Rongbin Xu, Tingting Ye, Yiwen Zhang, Zhihu Xu, Wenzhong Huang, Zhengyu Yang, Micheline SZS Coelho, Paulo H.N. Saldiva, Shanshan Li, Yuming Guo","doi":"10.1016/j.envpol.2025.127505","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127505","url":null,"abstract":"Wildfire fine particulate matter (PM<sub>2.5</sub>) is an emerging health concern, yet its effects on mosquito-borne diseases, particularly dengue, remain unclear. Brazil faces one of the world’s highest dengue burdens alongside frequent wildfires. We examined the association between short-term wildfire-specific PM<sub>2.5</sub> exposure and dengue-related hospitalizations across Brazil. We conducted a nationwide two-stage time-series analysis using daily dengue-related hospitalizations and daily wildfire-specific PM<sub>2.5</sub> concentrations across all Brazilian immediate-regions from 2008–2019. The wildfire-specific PM<sub>2.5</sub> estimates were derived from a chemical transport model and machine-learning calibration. Immediate region-specific associations between wildfire-specific PM<sub>2.5</sub> with dengue hospitalization risks were estimated using quasi-Poisson regression with distributed lag models and pooled using random-effects meta-analysis. Effect modification by socio-demographic factors, season, and forest cover was examined and attributable dengue hospitalizations were estimated. A 5 μg/m<sup>3</sup> increase in wildfire-specific PM<sub>2.5</sub> (lag 0–7 days) was associated with a 10.5% increase in dengue-related hospitalizations (Relative risk [RR]: 1.105 (95% Confidence Interval [CI]: 1.060–1.152), stronger for dengue fever (RR: 1.094, 95%CI: 1.049–1.141) than for Dengue Hemorrhagic Fever (DHF) (1.174, 0.754–1.831). Associations were consistent across sex, age groups, and regions, with higher risks in the elderly for DHF. Risks were greater during the dry season and in less densely populated areas. An estimated 28,994 dengue-related hospitalizations (95% CI: 16,737–40,867) were attributable to wildfire-specific PM<sub>2.5</sub> exposure in Brazil, averaging 17.3 per 100,000 population annually. The Northeast region had the highest number of attributable dengue-related hospitalizations, while the Southeast region had higher population-level impact. No association was found with non-wildfire PM<sub>2.5</sub>. Wildfire-specific PM<sub>2.5</sub> exposure increases dengue-related hospitalization risk in Brazil, underscoring the need to integrate wildfire smoke into dengue and vector surveillance and to target high-risk areas to reduce disease burden.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"28 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Human Health Risk Assessment of Exposure to Heavy Rare Earth Elements Based on Animal Toxicity Experiments and Physiologically Based Pharmacokinetic Modeling","authors":"Shuyun Jiang, Hao Zhou, Liying Zhang, Jian Zhao, Tianzong Zhou, Luyun Zhang, Lili Liu, Qing Wang, Xiumei Xing, Daochuan Li","doi":"10.1016/j.envpol.2025.127485","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127485","url":null,"abstract":"","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"134 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.envpol.2025.127493
Alexandra Loll, Elke Eilebrecht, Christoph Schäfers, Henner Hollert, Sebastian Eilebrecht
Due to their high stability and water solubility, some artificial sweeteners reach aquatic environments and persist there. Despite the identification of sucralose, acesulfame, saccharin, and cyclamate as emerging pollutants in literature for over a decade, no environmental risk assessment of these substances has been conducted to date. However, the European Food Safety Authority (EFSA) is currently undertaking a re-evaluation of the authorization of artificial sweeteners, still ongoing for sucralose and cyclamate. The present review demonstrates that all four sweeteners have been identified as being persistent and very mobile in the aquatic environment. The focal point of this review pertains to the ecotoxicity of the four aforementioned sweeteners. The acute toxicity studies conducted on aquatic model organisms demonstrated that there was no overall acute hazard. Nevertheless, a pronounced lack of chronic toxicity studies persists, and data at environmentally relevant concentrations remain scarce, representing a significant knowledge gap. This is a matter of concern, as this review indicates that numerous studies employing alternative endpoints have identified effects within environmentally relevant concentrations. In light of the potential for long-term effects, the reauthorization of the addressed artificial sweeteners warrants careful reconsideration.
{"title":"Bitter Truth about Artificial Sweeteners: A Critical Review on the Ecotoxicity of Sucralose, Acesulfame, Saccharin and Cyclamate","authors":"Alexandra Loll, Elke Eilebrecht, Christoph Schäfers, Henner Hollert, Sebastian Eilebrecht","doi":"10.1016/j.envpol.2025.127493","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127493","url":null,"abstract":"Due to their high stability and water solubility, some artificial sweeteners reach aquatic environments and persist there. Despite the identification of sucralose, acesulfame, saccharin, and cyclamate as emerging pollutants in literature for over a decade, no environmental risk assessment of these substances has been conducted to date. However, the European Food Safety Authority (EFSA) is currently undertaking a re-evaluation of the authorization of artificial sweeteners, still ongoing for sucralose and cyclamate. The present review demonstrates that all four sweeteners have been identified as being persistent and very mobile in the aquatic environment. The focal point of this review pertains to the ecotoxicity of the four aforementioned sweeteners. The acute toxicity studies conducted on aquatic model organisms demonstrated that there was no overall acute hazard. Nevertheless, a pronounced lack of chronic toxicity studies persists, and data at environmentally relevant concentrations remain scarce, representing a significant knowledge gap. This is a matter of concern, as this review indicates that numerous studies employing alternative endpoints have identified effects within environmentally relevant concentrations. In light of the potential for long-term effects, the reauthorization of the addressed artificial sweeteners warrants careful reconsideration.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"27 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.envpol.2025.127469
Todd R. Harris, Adam Morris, Erin Lange, D.A.D. Blair, Anaïs Remili, Robert J. Letcher, Amy A. Rand
Environmental contaminants, particularly persistent organic pollutants (POPs) and mercury, pose significant threats to wildlife health, with complex interactions between contaminants and biological processes that are challenging to assess in field studies. This research investigates the oxylipin metabolome in liver samples from polar bears (Ursus maritimus) in two geographically distinct subpopulations from Western Hudson Bay (WHB) and Baffin Bay (BB), Canada, with the aim of elucidating the impact of environmental contaminants on metabolic and inflammatory pathways. Oxylipins, bioactive lipid metabolites derived from polyunsaturated fatty acids, regulate critical biological processes such as inflammation and vascular tone. We identified significant differences in oxylipin levels between the two subpopulations, with WHB bears showing higher concentrations of several key metabolites, including Prostaglandin E2 (PGE2) and 5-iPF2a-VI, an isoprostane, both associated with inflammation and oxidative stress. Contaminant analysis revealed elevated levels of specific POPs, including polybrominated diphenyl ether (PBDEs), in WHB polar bears. These results suggest a potential link between contaminant exposure and altered oxylipin metabolism, which may contribute to liver dysfunction and inflammation. Multivariate analysis also revealed correlations between contaminants and metabolic pathways related to liver disease, including arginine biosynthesis and alanine, aspartate and glutamate metabolism. Our findings underscore the importance of considering the interplay between environmental contaminants and lipid signaling in wildlife health, particularly in the context of Arctic ecosystems, and highlight the need for further research to explore the long-term impacts of these exposures on polar bear populations and other wildlife species in the Arctic.
{"title":"Lipid oxidation and metabolism in relation to contaminants in polar bears from the Canadian High Arctic and Hudson Bay","authors":"Todd R. Harris, Adam Morris, Erin Lange, D.A.D. Blair, Anaïs Remili, Robert J. Letcher, Amy A. Rand","doi":"10.1016/j.envpol.2025.127469","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127469","url":null,"abstract":"Environmental contaminants, particularly persistent organic pollutants (POPs) and mercury, pose significant threats to wildlife health, with complex interactions between contaminants and biological processes that are challenging to assess in field studies. This research investigates the oxylipin metabolome in liver samples from polar bears (<em>Ursus maritimus</em>) in two geographically distinct subpopulations from Western Hudson Bay (WHB) and Baffin Bay (BB), Canada, with the aim of elucidating the impact of environmental contaminants on metabolic and inflammatory pathways. Oxylipins, bioactive lipid metabolites derived from polyunsaturated fatty acids, regulate critical biological processes such as inflammation and vascular tone. We identified significant differences in oxylipin levels between the two subpopulations, with WHB bears showing higher concentrations of several key metabolites, including Prostaglandin E<sub>2</sub> (PGE2) and 5-iPF2a-VI, an isoprostane, both associated with inflammation and oxidative stress. Contaminant analysis revealed elevated levels of specific POPs, including polybrominated diphenyl ether (PBDEs), in WHB polar bears. These results suggest a potential link between contaminant exposure and altered oxylipin metabolism, which may contribute to liver dysfunction and inflammation. Multivariate analysis also revealed correlations between contaminants and metabolic pathways related to liver disease, including arginine biosynthesis and alanine, aspartate and glutamate metabolism. Our findings underscore the importance of considering the interplay between environmental contaminants and lipid signaling in wildlife health, particularly in the context of Arctic ecosystems, and highlight the need for further research to explore the long-term impacts of these exposures on polar bear populations and other wildlife species in the Arctic.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"15 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taste and odor events in lacustrine systems, primarily driven by 2-methylisoborneol (2-MIB), pose a global challenge to drinking water safety. In this study of eastern Lake Taihu, we conducted synchronous monitoring of 2-MIB concentrations, environmental parameters, and the abundance of genes associated with odor production in bacteria in surface water, bottom water, and sediment porewater from April to December 2023. Our findings revealed a steep vertical concentration gradient, with 2-MIB in sediment porewater reaching a peak mean concentration of 1150 ng/L in August, a level over four times higher than that in the overlying surface water (280 ng/L). Piecewise structural equation modeling (SEM) quantitatively confirmed a distinct "bottom-up" transport pathway. Porewater 2-MIB concentrations directly influenced bottom-water levels (path coefficient, β=0.37), which in turn were the primary determinant of surface-water concentrations (β=0.93). Furthermore, our analysis unveiled divergent mechanisms driving 2-MIB dynamics; concentrations in the overlying water were strongly correlated with aquatic primary productivity, whereas those in porewater depended on the distinct biogeochemical environment of the sediment layer. This study shows that the sediment is a key internal source of 2-MIB in eastern Lake Taihu. We reveal a bottom-up transport pathway that drives odor pollution in the overlying water, providing critical scientific insights for managing taste and odor problems in shallow lake ecosystems.
{"title":"Sediment as a Key Internal Source of 2-Methylisoborneol (2-MIB) in Large Shallow Lakes: A Case Study of Lake Taihu","authors":"Donghao Wu, Tiancheng Sun, Qingchun Guo, Yadong Shi, Xiaoying Cheng, Aichun Shen","doi":"10.1016/j.envpol.2025.127397","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127397","url":null,"abstract":"Taste and odor events in lacustrine systems, primarily driven by 2-methylisoborneol (2-MIB), pose a global challenge to drinking water safety. In this study of eastern Lake Taihu, we conducted synchronous monitoring of 2-MIB concentrations, environmental parameters, and the abundance of genes associated with odor production in bacteria in surface water, bottom water, and sediment porewater from April to December 2023. Our findings revealed a steep vertical concentration gradient, with 2-MIB in sediment porewater reaching a peak mean concentration of 1150 ng/L in August, a level over four times higher than that in the overlying surface water (280 ng/L). Piecewise structural equation modeling (SEM) quantitatively confirmed a distinct \"bottom-up\" transport pathway. Porewater 2-MIB concentrations directly influenced bottom-water levels (path coefficient, β=0.37), which in turn were the primary determinant of surface-water concentrations (β=0.93). Furthermore, our analysis unveiled divergent mechanisms driving 2-MIB dynamics; concentrations in the overlying water were strongly correlated with aquatic primary productivity, whereas those in porewater depended on the distinct biogeochemical environment of the sediment layer. This study shows that the sediment is a key internal source of 2-MIB in eastern Lake Taihu. We reveal a bottom-up transport pathway that drives odor pollution in the overlying water, providing critical scientific insights for managing taste and odor problems in shallow lake ecosystems.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"115 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.envpol.2025.127495
Zhitong Li , Xiangsheng Hong , Wang Liu , Le Zhang , Juan Wang , Wei Sang , Saihong Yan , Jinmiao Zha
Beyond regulating glucose metabolism and energy homeostasis, insulin dysregulation impairs mammalian fertility by disrupting hormone secretion, but its role in fish reproduction remains poorly characterized. Here, a transcriptome-based systematic review of 19 screened studies revealed that exposure to pollutants (bisphenols) caused dual changes in insulin signaling and reproductive processes across species, suggesting a potential mechanistic link. Bisphenols (BPs) are a typical class of endocrine-disrupting chemicals. Molecular docking assessed binding affinities of ten BPs to insulin and its receptor across species, with BPZ and BPM showing stronger affinities than BPA. Juvenile Chinese rare minnows (Gobiocypris rarus) were exposed to BPA, BPZ, or BPM (1–100 μg/L) for 60 days. The reproductive development including reduced gonadosomatic index, inhibited oogenesis, and enhanced spermatogenesis were impaired at all treatments. Moreover, insulin-related gene expression along the HPG axis was altered, accompanied by suppressed insulin and disrupted sex hormone levels. Spearman correlation analysis revealed strong correlations between insulin and HPG axis hormones in males (r = 0.41–0.90, p = 0.02–0.21) and fair correlations in females (r = 0.48–0.61, p = 0.11–0.23). Those findings indicated that bisphenols-induced reproductive toxicity maybe mediated by insulin homeostasis disruption.
{"title":"Is reproductive toxicity of bisphenols an adverse outcome from insulin homeostasis disruption in fish?","authors":"Zhitong Li , Xiangsheng Hong , Wang Liu , Le Zhang , Juan Wang , Wei Sang , Saihong Yan , Jinmiao Zha","doi":"10.1016/j.envpol.2025.127495","DOIUrl":"10.1016/j.envpol.2025.127495","url":null,"abstract":"<div><div>Beyond regulating glucose metabolism and energy homeostasis, insulin dysregulation impairs mammalian fertility by disrupting hormone secretion, but its role in fish reproduction remains poorly characterized. Here, a transcriptome-based systematic review of 19 screened studies revealed that exposure to pollutants (bisphenols) caused dual changes in insulin signaling and reproductive processes across species, suggesting a potential mechanistic link. Bisphenols (BPs) are a typical class of endocrine-disrupting chemicals. Molecular docking assessed binding affinities of ten BPs to insulin and its receptor across species, with BPZ and BPM showing stronger affinities than BPA. Juvenile Chinese rare minnows (<em>Gobiocypris rarus</em>) were exposed to BPA, BPZ, or BPM (1–100 μg/L) for 60 days. The reproductive development including reduced gonadosomatic index, inhibited oogenesis, and enhanced spermatogenesis were impaired at all treatments. Moreover, insulin-related gene expression along the HPG axis was altered, accompanied by suppressed insulin and disrupted sex hormone levels. Spearman correlation analysis revealed strong correlations between insulin and HPG axis hormones in males (<em>r</em> = 0.41–0.90, <em>p</em> = 0.02–0.21) and fair correlations in females (<em>r</em> = 0.48–0.61, <em>p</em> = 0.11–0.23). Those findings indicated that bisphenols-induced reproductive toxicity maybe mediated by insulin homeostasis disruption.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"390 ","pages":"Article 127495"},"PeriodicalIF":7.3,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.envpol.2025.127496
Carmen Peuters, Joan Birulés, Toni Galmés, Xavier Basagaña, Alan Dominguez, Maria Foraster, Laura Gomez-Herrera, María Dolores Gómez-Roig, Elisa Llurba, Ioar Rivas, Jessica Sánchez-Galán, Laura Bosch, Mireia Gascon, Payam Dadvand, Jordi Sunyer
Although the prenatal life is a critical period for brain development, very few studies have focused on prenatal exposure to air pollution in relation to infant cognition, and most studies have relied on carer-reported outcome assessment. We examined the association between prenatal exposure to air pollution and objective measurement of infant cognitive development using an eye-tracking methodology. The study was based on data from a subset of 168 mother-child pairs participating in the Barcelona Life Study Cohort (BiSC), Spain (2018-2023). Total exposure to nitrogen dioxide (NO2), black carbon (BC), particulate matter (PM2.5), and PM2.5 copper (Cu) and iron (Fe) content during pregnancy were assessed through integrating estimates of land-use regression (LUR) models with data on time spent at home, workplace, and during commuting. Cognitive performance was assessed longitudinally at 6 months (n=156) and 18 months (n=62) of age through an eye-tracking Visual Paired-Comparison (VPC) task that measured short-term recognition memory for faces. Linear mixed models were applied to explore the association between prenatal air pollution exposure and the percentage looking time at novel compared to familiar stimuli on the VPC task, adjusting for potential confounders. Results showed worse cognitive performance with increasing air pollution exposure: For each interquartile range increase of NO2, BC, PM2.5, Cu and Fe, novelty preference decreased with -2.0 (95% CI: -4.7, 0.6), -2.5 (-4.6, -0.5), -3.9 (-7.0, -0.9), -2.1 (-4.0, -0.3), and -1.4 (-3.2, 0.3), respectively. There were suggestions for potentially stronger associations in boys. The findings highlight the pregnancy period as a window of vulnerability for the impact of air pollution on the developing brain, and values eye-tracking as an objective non-invasive tool for early detection of such impact.
{"title":"Prenatal exposure to air pollution and infant cognitive development using an eye-tracking Visual Paired-Comparison task","authors":"Carmen Peuters, Joan Birulés, Toni Galmés, Xavier Basagaña, Alan Dominguez, Maria Foraster, Laura Gomez-Herrera, María Dolores Gómez-Roig, Elisa Llurba, Ioar Rivas, Jessica Sánchez-Galán, Laura Bosch, Mireia Gascon, Payam Dadvand, Jordi Sunyer","doi":"10.1016/j.envpol.2025.127496","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.127496","url":null,"abstract":"Although the prenatal life is a critical period for brain development, very few studies have focused on prenatal exposure to air pollution in relation to infant cognition, and most studies have relied on carer-reported outcome assessment. We examined the association between prenatal exposure to air pollution and objective measurement of infant cognitive development using an eye-tracking methodology. The study was based on data from a subset of 168 mother-child pairs participating in the Barcelona Life Study Cohort (BiSC), Spain (2018-2023). Total exposure to nitrogen dioxide (NO<sub>2</sub>), black carbon (BC), particulate matter (PM<sub>2.5</sub>), and PM<sub>2.5</sub> copper (Cu) and iron (Fe) content during pregnancy were assessed through integrating estimates of land-use regression (LUR) models with data on time spent at home, workplace, and during commuting. Cognitive performance was assessed longitudinally at 6 months (<em>n</em>=156) and 18 months (<em>n</em>=62) of age through an eye-tracking Visual Paired-Comparison (VPC) task that measured short-term recognition memory for faces. Linear mixed models were applied to explore the association between prenatal air pollution exposure and the percentage looking time at novel compared to familiar stimuli on the VPC task, adjusting for potential confounders. Results showed worse cognitive performance with increasing air pollution exposure: For each interquartile range increase of NO<sub>2</sub>, BC, PM<sub>2.5</sub>, Cu and Fe, novelty preference decreased with -2.0 (95% CI: -4.7, 0.6), -2.5 (-4.6, -0.5), -3.9 (-7.0, -0.9), -2.1 (-4.0, -0.3), and -1.4 (-3.2, 0.3), respectively. There were suggestions for potentially stronger associations in boys. The findings highlight the pregnancy period as a window of vulnerability for the impact of air pollution on the developing brain, and values eye-tracking as an objective non-invasive tool for early detection of such impact.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"26 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.envpol.2025.127504
Qian Zhao , Qinghai Guo , Xingqing He , Qixin Duan , Yaowu Cao , Ziyin Zhang , Wenqi Zhu , Ziqi He , Yu Li , Huai Wang
The formation of thioantimonates in sulfidic waters significantly increases the complexity of antimony (Sb) geochemistry, yet the factors controlling their prevalence in natural systems remain poorly constrained. This study systematically examined the competitive thiolation kinetics among Sb, arsenic (As), and tungsten (W), elements that commonly coexist in sulfidic geothermal waters. Experimental results demonstrate that under sulfide-limited conditions, the kinetics sequence is As > Sb ≈ W, while the kinetic stability of the resulting thio-anions follows thioarsenates > thioantimonates > thiotungstates. This coupled kinetic-stability framework successfully explains the distribution of Sb speciation observed in representative sulfidic hot springs within the Yunnan-Sichuan-Tibet geothermal province (China), where high Sb concentrations (4.32–2128.7 μg/L) originate from rock leaching and magmatic fluids. In sulfide-deficient hot springs, coexisting As and W act as inhibitors of Sb thiolation through competitive exclusion, leading to oxyanion dominance; conversely, in sulfide-sufficient hot springs, they become promoters, enhancing thioantimonates formation (up to 56.6 % of total Sb) potentially through an ionic strength effect. Our findings redefine the competitive thiolation hierarchy among Sb, As, and W and provide a quantitative framework for predicting Sb speciation in sulfidic environments, which is critical for assessing its environmental fate.
{"title":"Competitive thiolation kinetics of antimony, arsenic, and tungsten controlling antimony speciation in sulfidic hot springs","authors":"Qian Zhao , Qinghai Guo , Xingqing He , Qixin Duan , Yaowu Cao , Ziyin Zhang , Wenqi Zhu , Ziqi He , Yu Li , Huai Wang","doi":"10.1016/j.envpol.2025.127504","DOIUrl":"10.1016/j.envpol.2025.127504","url":null,"abstract":"<div><div>The formation of thioantimonates in sulfidic waters significantly increases the complexity of antimony (Sb) geochemistry, yet the factors controlling their prevalence in natural systems remain poorly constrained. This study systematically examined the competitive thiolation kinetics among Sb, arsenic (As), and tungsten (W), elements that commonly coexist in sulfidic geothermal waters. Experimental results demonstrate that under sulfide-limited conditions, the kinetics sequence is As > Sb ≈ W, while the kinetic stability of the resulting thio-anions follows thioarsenates > thioantimonates > thiotungstates. This coupled kinetic-stability framework successfully explains the distribution of Sb speciation observed in representative sulfidic hot springs within the Yunnan-Sichuan-Tibet geothermal province (China), where high Sb concentrations (4.32–2128.7 μg/L) originate from rock leaching and magmatic fluids. In sulfide-deficient hot springs, coexisting As and W act as inhibitors of Sb thiolation through competitive exclusion, leading to oxyanion dominance; conversely, in sulfide-sufficient hot springs, they become promoters, enhancing thioantimonates formation (up to 56.6 % of total Sb) potentially through an ionic strength effect. Our findings redefine the competitive thiolation hierarchy among Sb, As, and W and provide a quantitative framework for predicting Sb speciation in sulfidic environments, which is critical for assessing its environmental fate.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"390 ","pages":"Article 127504"},"PeriodicalIF":7.3,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：