Benzo (k) fluoranthene (BkF) has adverse effects on male reproduction, but its specific mechanism of action is still unclear. This study focused on the role of RNA reading protein YTHDF2 and its mechanism in BkF induced male reproductive injury. Mouse spermatocytes were exposed to 0, 40, 80, 160 μM BkF. It was found that BkF significantly increased the apoptosis of GC-2 spermatogonia and decreased its survival rate. BCL2 in spermatocytes decreased significantly, while the expression of P53 and BAX exhibited a notable increase. Interestingly, the expression of RNA reading protein YTHDF2 progressively rose in tandem with the escalating BkF exposure dosage. Overexpression of YTHDF2 significantly reduced the viability of cells and increased the apoptosis rate. Meanwhile, there was a substantial increase in the expression of P53 and BAX, BCL2 was significantly down-regulated. On the contrary, interfering with YTHDF2 increased cell proliferation and reduced cell apoptosis. Furthermore, YTHDF2 overexpression exacerbated the decrease in cell viability under BkF exposure, while YTHDF2 knockdown was the opposite. The results from the RIP assay demonstrated a significant enhancement in the interaction of YTHDF2 protein to with BCL2 mRNA following the overexpression of YTHDF2. In addition, animal experiments showed that there was an increase in apoptosis and a decrease in proliferation of testicular cells in mice in the high-dose (30 mg/kg) BkF group by TUNEL staining and Ki67 staining. Immunohistochemical analysis showed that Bcl2 levels were significantly lower in the high-dose group than in the control group, while YTHDF2, P53 and BAX were dramatically increased. In summary, our study suggests that YTHDF2 has been implicated in BkF-induced male reproductive injury by promoting the degradation of BCL2.
{"title":"RNA reading protein YTHDF2 mediates Benzo(k)fluoranthene induced male reproductive injury by regulating the stability of BCL2.","authors":"Ya-Wen Li, Dan-Dan Wang, Hong-Qiang Chen, Yong Zeng, Na Wang, Yu Shi, Jiang-Ying Li, Ni-Ya Zhou, Da-Peng Wang, Qing Chen, Xue Han, Jia Cao, Wen-Bin Liu","doi":"10.1016/j.envpol.2024.124889","DOIUrl":"https://doi.org/10.1016/j.envpol.2024.124889","url":null,"abstract":"<p><p>Benzo (k) fluoranthene (BkF) has adverse effects on male reproduction, but its specific mechanism of action is still unclear. This study focused on the role of RNA reading protein YTHDF2 and its mechanism in BkF induced male reproductive injury. Mouse spermatocytes were exposed to 0, 40, 80, 160 μM BkF. It was found that BkF significantly increased the apoptosis of GC-2 spermatogonia and decreased its survival rate. BCL2 in spermatocytes decreased significantly, while the expression of P53 and BAX exhibited a notable increase. Interestingly, the expression of RNA reading protein YTHDF2 progressively rose in tandem with the escalating BkF exposure dosage. Overexpression of YTHDF2 significantly reduced the viability of cells and increased the apoptosis rate. Meanwhile, there was a substantial increase in the expression of P53 and BAX, BCL2 was significantly down-regulated. On the contrary, interfering with YTHDF2 increased cell proliferation and reduced cell apoptosis. Furthermore, YTHDF2 overexpression exacerbated the decrease in cell viability under BkF exposure, while YTHDF2 knockdown was the opposite. The results from the RIP assay demonstrated a significant enhancement in the interaction of YTHDF2 protein to with BCL2 mRNA following the overexpression of YTHDF2. In addition, animal experiments showed that there was an increase in apoptosis and a decrease in proliferation of testicular cells in mice in the high-dose (30 mg/kg) BkF group by TUNEL staining and Ki67 staining. Immunohistochemical analysis showed that Bcl2 levels were significantly lower in the high-dose group than in the control group, while YTHDF2, P53 and BAX were dramatically increased. In summary, our study suggests that YTHDF2 has been implicated in BkF-induced male reproductive injury by promoting the degradation of BCL2.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1016/j.envpol.2024.124875
Demand for unconventional crude oils continues to drive the production of diluted bitumen (dilbit) within Western Canada, promoting increased transport volumes across the extensive 700,000 km pipeline system of Canada and the USA. Despite this vast extent of terrestrial transport, the current understanding of the behavior and fate of spilled dilbit within shallow groundwater systems is limited. To this end, oil spill experiments with a dilbit (Cold Lake Blend) and a physicochemically similar conventional heavy crude oil (Conventional Heavy Blend) were conducted for 104 days in large soil columns (1 m height × 0.6 m diameter) engineered to model contaminant transport in the unsaturated (vadose) zone. Around two-fold greater concentrations and 6–41 % faster rates of vadose zone transport of benzene, toluene, ethylbenzene and xylenes (BTEX) and polycyclic aromatic compounds (PACs) were observed in the dilbit- compared to conventional heavy crude-contaminated columns. As determined by Orbitrap mass spectrometry, the OxSx species abundances in the acid extractable organics (AEOs) fraction of column leachate from both oil types increased over time, ostensibly due to microbial degradation of petroleum. Bioaccumulation of petroleum constituents in fathead minnow (Pimephales promelas) larvae exposed to contaminated leachate was confirmed through the induction of developmental malformations lasting up to 34 days and increased abundance of cyp1a mRNA observed throughout the experiment. Toxicity was comparable between the two oils but could not be fully attributed to metals, BTEX, PACs or AEOs, implying the presence of uncharacterized teratogens capable of being transported within the vadose zone following terrestrial dilbit and conventional heavy crude oil surface spills.
{"title":"Behavior and toxicological impact of spilled diluted bitumen and conventional heavy crude oil in the unsaturated zone","authors":"","doi":"10.1016/j.envpol.2024.124875","DOIUrl":"10.1016/j.envpol.2024.124875","url":null,"abstract":"<div><p>Demand for unconventional crude oils continues to drive the production of diluted bitumen (dilbit) within Western Canada, promoting increased transport volumes across the extensive 700,000 km pipeline system of Canada and the USA. Despite this vast extent of terrestrial transport, the current understanding of the behavior and fate of spilled dilbit within shallow groundwater systems is limited. To this end, oil spill experiments with a dilbit (Cold Lake Blend) and a physicochemically similar conventional heavy crude oil (Conventional Heavy Blend) were conducted for 104 days in large soil columns (1 m height × 0.6 m diameter) engineered to model contaminant transport in the unsaturated (vadose) zone. Around two-fold greater concentrations and 6–41 % faster rates of vadose zone transport of benzene, toluene, ethylbenzene and xylenes (BTEX) and polycyclic aromatic compounds (PACs) were observed in the dilbit- compared to conventional heavy crude-contaminated columns. As determined by Orbitrap mass spectrometry, the O<sub>x</sub>S<sub>x</sub> species abundances in the acid extractable organics (AEOs) fraction of column leachate from both oil types increased over time, ostensibly due to microbial degradation of petroleum. Bioaccumulation of petroleum constituents in fathead minnow (<em>Pimephales promelas</em>) larvae exposed to contaminated leachate was confirmed through the induction of developmental malformations lasting up to 34 days and increased abundance of <em>cyp1a</em> mRNA observed throughout the experiment. Toxicity was comparable between the two oils but could not be fully attributed to metals, BTEX, PACs or AEOs, implying the presence of uncharacterized teratogens capable of being transported within the vadose zone following terrestrial dilbit and conventional heavy crude oil surface spills.</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0269749124015896/pdfft?md5=f31cc9ee554777a94fb6b64aa92fab1a&pid=1-s2.0-S0269749124015896-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1016/j.envpol.2024.124784
Sewages from duck farms are often recognized as a major source of antimicrobial resistance and pathogenic bacteria discharged to natural water bodies, but few studies depicted the dynamic changes in resistome and microbial communities in the rivers under immense exposure of sewage discharge. In this study, we investigated the ecological and environmental risks of duck sewages to the rivers that geographically near to the duck farms with short-distance (<1 km) using 16S rRNA amplicon and metagenomic sequencing. The results showed that a total of 20 ARG types were identified with abundances ranged from 0.61 to 1.33 cpc. Of note, the genes modulate resistances against aminoglycoside, bacitracin and beta-lactam were the most abundant ARGs. Limnohabitans, Fluviibacter and Cyanobium were the top 3 predominant genera in the microbial community. The alpha diversity of overall microbial community decrease while the abundance of pathogen increase during the input of sewage within 200 m. Sul1 and bacA were the dominant ARGs brought from duck farm sewage. The community variations of ARGs and microbiome were primarily driven by pH and temperature. Total phosphorus was significantly correlated to alpha diversity and top 30 ARGs subtype. Stochastic processes was the dominated microbial assembly pattern and did not be altered by sewage. We also highlighted the ecological risk caused by blaGES which possibly could be mitigated by Cyanobacteria, and the natural water body can purify partial ARGs as well as microbiome from duck farms sewage. These findings expanded our knowledge regarding the ecological risks by wastes from the livestock farm, and underscoring the necessity to monitor ARGs in farm-surrounding water bodies.
{"title":"Metagenomic analysis unveiled the response of microbial community and antimicrobial resistome in natural water body to duck farm sewage","authors":"","doi":"10.1016/j.envpol.2024.124784","DOIUrl":"10.1016/j.envpol.2024.124784","url":null,"abstract":"<div><p>Sewages from duck farms are often recognized as a major source of antimicrobial resistance and pathogenic bacteria discharged to natural water bodies, but few studies depicted the dynamic changes in resistome and microbial communities in the rivers under immense exposure of sewage discharge. In this study, we investigated the ecological and environmental risks of duck sewages to the rivers that geographically near to the duck farms with short-distance (<1 km) using 16S rRNA amplicon and metagenomic sequencing. The results showed that a total of 20 ARG types were identified with abundances ranged from 0.61 to 1.33 cpc. Of note, the genes modulate resistances against aminoglycoside, bacitracin and beta-lactam were the most abundant ARGs. <em>Limnohabitans</em>, <em>Fluviibacter</em> and <em>Cyanobium</em> were the top 3 predominant genera in the microbial community. The alpha diversity of overall microbial community decrease while the abundance of pathogen increase during the input of sewage within 200 m. <em>Sul1</em> and <em>bacA</em> were the dominant ARGs brought from duck farm sewage. The community variations of ARGs and microbiome were primarily driven by pH and temperature. Total phosphorus was significantly correlated to alpha diversity and top 30 ARGs subtype. Stochastic processes was the dominated microbial assembly pattern and did not be altered by sewage. We also highlighted the ecological risk caused by <em>bla</em><sub>GES</sub> which possibly could be mitigated by Cyanobacteria, and the natural water body can purify partial ARGs as well as microbiome from duck farms sewage. These findings expanded our knowledge regarding the ecological risks by wastes from the livestock farm, and underscoring the necessity to monitor ARGs in farm-surrounding water bodies.</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1016/j.envpol.2024.124885
Polybrominated diphenyl ethers (PBDEs) and their alternatives (e.g., dechlorane plus (DPs) and decabromodiphenyl ethane (DBDPE)) are ubiquitous in various environmental media. However, limited data is available on these chemicals in edible fish species from the wide-open South China Sea (SCS). In the present study, ten legacy PBDEs and three substitutions (DBDPE and two DPs) were analyzed in 16 wild fish species sampled from the open SCS to investigate their spatial and species-specific variations. The results showed that the total concentrations of PBDEs, DBDPE, and DPs in fish samples were in the range of 1.69–47.6, not detected (nd) to 21.0, and nd to 3.80 ng/g lipid weight (lw), respectively. BDEs 47, 209 and 100 were the dominant target PBDE congeners, representing 49.2%, 17.2% and 9.93% of the total PBDE concentrations, respectively. Higher concentrations of PBDEs, DBDPE, and DPs were found in fish species from the Wanshan Archipelago compared to those from the Mischief Reef and the Yongxing Island, suggesting the significant influence of anthropogenic activities. Species-specific differences in levels of PBDEs were observed, with the order of bathydemersal > demersal > pelagic ≈ reef-associated > benthopelagic species. The average fanti value of all fish samples was 0.68, suggesting commercial DP products as a contamination source. The levels of PBDEs, DPs, and DBDPE in fish samples were relatively low compared with those from other locations around the globe. Finally, the health risks concerning the ingestion of BDEs 47, 99, 153 and 209 via fish consumption collected from the SCS are negligible.
{"title":"Evidence of polybrominated diphenyl ethers (PBDEs) and alternative halogenated flame retardants (AHFRs) in wild fish species from the remote tropical marine environment, south China sea","authors":"","doi":"10.1016/j.envpol.2024.124885","DOIUrl":"10.1016/j.envpol.2024.124885","url":null,"abstract":"<div><p>Polybrominated diphenyl ethers (PBDEs) and their alternatives (e.g., dechlorane plus (DPs) and decabromodiphenyl ethane (DBDPE)) are ubiquitous in various environmental media. However, limited data is available on these chemicals in edible fish species from the wide-open South China Sea (SCS). In the present study, ten legacy PBDEs and three substitutions (DBDPE and two DPs) were analyzed in 16 wild fish species sampled from the open SCS to investigate their spatial and species-specific variations. The results showed that the total concentrations of PBDEs, DBDPE, and DPs in fish samples were in the range of 1.69–47.6, not detected (nd) to 21.0, and nd to 3.80 ng/g lipid weight (lw), respectively. BDEs 47, 209 and 100 were the dominant target PBDE congeners, representing 49.2%, 17.2% and 9.93% of the total PBDE concentrations, respectively. Higher concentrations of PBDEs, DBDPE, and DPs were found in fish species from the Wanshan Archipelago compared to those from the Mischief Reef and the Yongxing Island, suggesting the significant influence of anthropogenic activities. Species-specific differences in levels of PBDEs were observed, with the order of bathydemersal > demersal > pelagic ≈ reef-associated > benthopelagic species. The average <em>f</em><sub>anti</sub> value of all fish samples was 0.68, suggesting commercial DP products as a contamination source. The levels of PBDEs, DPs, and DBDPE in fish samples were relatively low compared with those from other locations around the globe. Finally, the health risks concerning the ingestion of BDEs 47, 99, 153 and 209 via fish consumption collected from the SCS are negligible.</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1016/j.envpol.2024.124881
In residential environment, NO2 is an important air pollutant. Yet, the dynamics of indoor NO2 and source contributions to human exposure are not well understood. Here, we conducted a continuous NO2 measurement in and out of eight households in Guangzhou, China. Paired high time-resolution NO2 data sets indoors (kitchen, living room) and outdoors (balcony) were obtained with NO2 monitors. We summarized the indoor and outdoor NO2 levels, identified temporal variation patterns, analyzed indoor-outdoor relationships, and quantified source contributions to indoor NO2 exposure. Indoor NO2 were overall higher than outdoor NO2, and in most cases, the highest NO2 levels were observed in the kitchen. NO2 in the kitchen was characterized by multiple spikes associated with use of gas stoves, while NO2 in the living room was also elevated but the peaks were generally smaller. The indoor-outdoor correlations were stronger in winter than in summer, and were stronger in nighttime than daytime. The sources contributing to indoor NO2 were separated with a conceptual model. Overall, the outdoor NO2 source contributed 73%–76% of the NO2 in the kitchen, and 76%–85% in the living room. The source pattern was quite different: outdoor NO2 sources were present indoors all the time; by contrast, indoor NO2 sources were present sporadically but with a very high contribution. This has important implication to the exposure assessment that indoor NO2 sources lead to short-term high exposure, and deserves attention regarding acute health effects.
{"title":"Continuous measurement of the dynamics of residential indoor and outdoor NO2 and the contributions to human exposure","authors":"","doi":"10.1016/j.envpol.2024.124881","DOIUrl":"10.1016/j.envpol.2024.124881","url":null,"abstract":"<div><p>In residential environment, NO<sub>2</sub> is an important air pollutant. Yet, the dynamics of indoor NO<sub>2</sub> and source contributions to human exposure are not well understood. Here, we conducted a continuous NO<sub>2</sub> measurement in and out of eight households in Guangzhou, China. Paired high time-resolution NO<sub>2</sub> data sets indoors (kitchen, living room) and outdoors (balcony) were obtained with NO<sub>2</sub> monitors. We summarized the indoor and outdoor NO<sub>2</sub> levels, identified temporal variation patterns, analyzed indoor-outdoor relationships, and quantified source contributions to indoor NO<sub>2</sub> exposure. Indoor NO<sub>2</sub> were overall higher than outdoor NO<sub>2</sub>, and in most cases, the highest NO<sub>2</sub> levels were observed in the kitchen. NO<sub>2</sub> in the kitchen was characterized by multiple spikes associated with use of gas stoves, while NO<sub>2</sub> in the living room was also elevated but the peaks were generally smaller. The indoor-outdoor correlations were stronger in winter than in summer, and were stronger in nighttime than daytime. The sources contributing to indoor NO<sub>2</sub> were separated with a conceptual model. Overall, the outdoor NO<sub>2</sub> source contributed 73%–76% of the NO<sub>2</sub> in the kitchen, and 76%–85% in the living room. The source pattern was quite different: outdoor NO<sub>2</sub> sources were present indoors all the time; by contrast, indoor NO<sub>2</sub> sources were present sporadically but with a very high contribution. This has important implication to the exposure assessment that indoor NO<sub>2</sub> sources lead to short-term high exposure, and deserves attention regarding acute health effects.</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1016/j.envpol.2024.124877
Air quality degradation presents a significant public health challenge, particularly in rapidly urbanizing regions where changes in land use/land cover (LULC) can dramatically influence pollution levels. This study investigates the association between LULC changes and air pollution (AP) in the five fastest-growing cities of Bangladesh from 1998 to 2021. Leveraging satellite data from Landsat and Sentinel-5P, the analysis reveals a substantial increase in urban areas and sparse vegetation, with declines in dense vegetation and water bodies over this period. Urban expansion was most pronounced in Sylhet (22–254%), while Khulna experienced the largest increase in sparse vegetation (2–124%). Dense vegetation loss was highest in Dhaka (20–77%) and water bodies (9–59%) over this period. Concentrations of six major air pollutants (APTs) - aerosol index, CO, HCHO, NO2, O3, and SO2 - were quantified, showing alarmingly high levels in densely populated industrial and commercial zones. Pearson's correlation indicates strong positive associations between APTs and urban land indices (R > 0.8), while negative correlations exist with vegetation indices. Geographically weighted regression modeling identifies city centers with dense urban built-up as pollution hotspots, where APTs exhibited stronger impacts on land cover changes (R2 > 0.8) compared to other land classes. The highest daily emissions were observed for O3 (1031 tons) and CO (356 tons) at Chittagong in 2021. In contrast, areas with substantial green cover displayed weaker pollutant-land cover associations. These findings underscore how unplanned urbanization drives AP by replacing natural land cover with emission sources, providing crucial insights to guide sustainable urban planning strategies integrating pollution mitigation and environmental resilience.
{"title":"The urban air quality nexus: Assessing the interplay of land cover change and air pollution in emerging South Asian cities","authors":"","doi":"10.1016/j.envpol.2024.124877","DOIUrl":"10.1016/j.envpol.2024.124877","url":null,"abstract":"<div><p>Air quality degradation presents a significant public health challenge, particularly in rapidly urbanizing regions where changes in land use/land cover (LULC) can dramatically influence pollution levels. This study investigates the association between LULC changes and air pollution (AP) in the five fastest-growing cities of Bangladesh from 1998 to 2021. Leveraging satellite data from Landsat and Sentinel-5P, the analysis reveals a substantial increase in urban areas and sparse vegetation, with declines in dense vegetation and water bodies over this period. Urban expansion was most pronounced in Sylhet (22–254%), while Khulna experienced the largest increase in sparse vegetation (2–124%). Dense vegetation loss was highest in Dhaka (20–77%) and water bodies (9–59%) over this period. Concentrations of six major air pollutants (APTs) - aerosol index, CO, HCHO, NO<sub>2</sub>, O<sub>3</sub>, and SO<sub>2</sub> - were quantified, showing alarmingly high levels in densely populated industrial and commercial zones. Pearson's correlation indicates strong positive associations between APTs and urban land indices (R > 0.8), while negative correlations exist with vegetation indices. Geographically weighted regression modeling identifies city centers with dense urban built-up as pollution hotspots, where APTs exhibited stronger impacts on land cover changes (R<sup>2</sup> > 0.8) compared to other land classes. The highest daily emissions were observed for O<sub>3</sub> (1031 tons) and CO (356 tons) at Chittagong in 2021. In contrast, areas with substantial green cover displayed weaker pollutant-land cover associations. These findings underscore how unplanned urbanization drives AP by replacing natural land cover with emission sources, providing crucial insights to guide sustainable urban planning strategies integrating pollution mitigation and environmental resilience.</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1016/j.envpol.2024.124878
Tellurium is a technology-critical element (TCE), with relatively limited data on its behavior in the environment, especially the pedosphere. As with other TCEs, its more widespread use, especially in new energy sources, might lead to Te spillage during production or in the eventual waste. Investigation of tellurium's interaction with soil is a necessary step in the research into the physiochemical transformation and determining the mobility of different tellurium species. To broaden the hitherto scarce knowledge of tellurium behavior in the soil environment, selected soluble tellurium compounds were introduced into different types of well-characterized soil (content of fertilizers, organic matrix, clay minerals, Mn, Fe, pH). The study of Te(IV) and Te(VI) sorption indicated that after 7 days the sorption is quantitative and close to 100%. Addition of Fe2O3 to a soil deficient in Mn and Fe increases its sorption potential by about 10 percentage points. Based on fractionation study (0.11 mol L−1 CH3COOH, 0.1 mol L−1 ascorbic acid in oxalate buffer (pH 3), 30% H2O2 at 85 °C followed by 0.5 mol L−1 CH3COONH4), it was shown that the presence of Mn/Fe (oxyhydr)oxides plays an essential role in the mobility of Te, especially Te(VI), regardless of the soil type. In the soil poor in reducible fraction and rich in organic matrix (peat), the organic fraction was responsible for the immobilization of Te, especially Te(IV). Extraction of the mobile fraction after incubation in the presence of DI water (Te extraction: 7–8%), oxalic acid (5–7%) or citric acid (6%) (mimicking rhizosphere activity) indicated that these did not play a significant role in Te retention. Nevertheless, soil modification with biocarbon limited the effect of citrates on Te mobilization. This knowledge is fundamental, i.e. in the context of soil remediation processes and counteracting the migration of Te in the environment from anthropogenic sources (e.g. solar farms).
{"title":"Interaction of Te(IV) and Te(VI) with the soil matrix – Sorption and fractionation as a function of soil composition","authors":"","doi":"10.1016/j.envpol.2024.124878","DOIUrl":"10.1016/j.envpol.2024.124878","url":null,"abstract":"<div><p>Tellurium is a technology-critical element (TCE), with relatively limited data on its behavior in the environment, especially the pedosphere. As with other TCEs, its more widespread use, especially in new energy sources, might lead to Te spillage during production or in the eventual waste. Investigation of tellurium's interaction with soil is a necessary step in the research into the physiochemical transformation and determining the mobility of different tellurium species. To broaden the hitherto scarce knowledge of tellurium behavior in the soil environment, selected soluble tellurium compounds were introduced into different types of well-characterized soil (content of fertilizers, organic matrix, clay minerals, Mn, Fe, pH). The study of Te(IV) and Te(VI) sorption indicated that after 7 days the sorption is quantitative and close to 100%. Addition of Fe<sub>2</sub>O<sub>3</sub> to a soil deficient in Mn and Fe increases its sorption potential by about 10 percentage points. Based on fractionation study (0.11 mol L<sup>−1</sup> CH<sub>3</sub>COOH, 0.1 mol L<sup>−1</sup> ascorbic acid in oxalate buffer (pH 3), 30% H<sub>2</sub>O<sub>2</sub> at 85 °C followed by 0.5 mol L<sup>−1</sup> CH<sub>3</sub>COONH<sub>4</sub>), it was shown that the presence of Mn/Fe (oxyhydr)oxides plays an essential role in the mobility of Te, especially Te(VI), regardless of the soil type. In the soil poor in reducible fraction and rich in organic matrix (peat), the organic fraction was responsible for the immobilization of Te, especially Te(IV). Extraction of the mobile fraction after incubation in the presence of DI water (Te extraction: 7–8%), oxalic acid (5–7%) or citric acid (6%) (mimicking rhizosphere activity) indicated that these did not play a significant role in Te retention. Nevertheless, soil modification with biocarbon limited the effect of citrates on Te mobilization. This knowledge is fundamental, i.e. in the context of soil remediation processes and counteracting the migration of Te in the environment from anthropogenic sources (e.g. solar farms).</p></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-08-01DOI: 10.1016/j.envpol.2024.124508
Akira Tazaki, Delgama A S M Nishadhi, Ao Li, Lanyue Zhang, Than Htike Maw, Lisa Kondo-Ida, Kiyoshi Yanagisawa, Masashi Kato
Chemicals are representative environmental factors that affect human health. Recently, external exposure to a chemical of rhododenol (RD) caused chemical leukoderma, an acquired patchy hypopigmentation, in about 20,000 Asian people. The development of a hazard assessment system for accurate determination of leukoderma-inducible chemicals is required for the prevention of such tragedies. Case studies in humans have shown 6 chemicals, including RD, with a constitutive leukoderma-inducible potency and 3 chemicals with a photosensitive but not a constitutive leukoderma-inducible potency. In this study, the 6 positive and 3 negative control chemicals with or without constitutive leukoderma-inducible potencies were investigated by our previously developed in vivo hazard assessment system using tail skin of mice. Based on the results of validation, this study aimed to develop an in vitro hazard assessment system to correctly determine chemicals with a constitutive leukoderma-inducible potency. As expected, external exposure to the 6 positive control chemicals, but not external exposure to the 3 negative control chemicals, resulted in development of constitutive leukoderma in mouse tail skin with a decreased level of skin melanin and decreased number of melanocytes. Moreover, the 6 positive and 3 negative control chemicals were correctly distinguished by the presence or absence of endoplasmic reticulum (ER) stress induction, but not by tyrosinase-dependent cell death or production of reactive oxygen species (ROS), in immortalized normal melanocytes. The hazard assessment system using tail skin could be a solid in vivo tool to reliably determine the chemical potency of a chemical for constitutive leukoderma induction. The hazard assessment system focusing on ER stress induction in normal melanocytes might be a novel and convenient in vitro tool for accurately evaluating chemicals with leukoderma-inducible potencies. Thus, this study contributed to environmentology through the development of a screening system for preventing an environmental factor-related disease.
{"title":"Progression from in vivo validation to in vitro screening in hazard assessment for leukoderma-inducible chemicals.","authors":"Akira Tazaki, Delgama A S M Nishadhi, Ao Li, Lanyue Zhang, Than Htike Maw, Lisa Kondo-Ida, Kiyoshi Yanagisawa, Masashi Kato","doi":"10.1016/j.envpol.2024.124508","DOIUrl":"10.1016/j.envpol.2024.124508","url":null,"abstract":"<p><p>Chemicals are representative environmental factors that affect human health. Recently, external exposure to a chemical of rhododenol (RD) caused chemical leukoderma, an acquired patchy hypopigmentation, in about 20,000 Asian people. The development of a hazard assessment system for accurate determination of leukoderma-inducible chemicals is required for the prevention of such tragedies. Case studies in humans have shown 6 chemicals, including RD, with a constitutive leukoderma-inducible potency and 3 chemicals with a photosensitive but not a constitutive leukoderma-inducible potency. In this study, the 6 positive and 3 negative control chemicals with or without constitutive leukoderma-inducible potencies were investigated by our previously developed in vivo hazard assessment system using tail skin of mice. Based on the results of validation, this study aimed to develop an in vitro hazard assessment system to correctly determine chemicals with a constitutive leukoderma-inducible potency. As expected, external exposure to the 6 positive control chemicals, but not external exposure to the 3 negative control chemicals, resulted in development of constitutive leukoderma in mouse tail skin with a decreased level of skin melanin and decreased number of melanocytes. Moreover, the 6 positive and 3 negative control chemicals were correctly distinguished by the presence or absence of endoplasmic reticulum (ER) stress induction, but not by tyrosinase-dependent cell death or production of reactive oxygen species (ROS), in immortalized normal melanocytes. The hazard assessment system using tail skin could be a solid in vivo tool to reliably determine the chemical potency of a chemical for constitutive leukoderma induction. The hazard assessment system focusing on ER stress induction in normal melanocytes might be a novel and convenient in vitro tool for accurately evaluating chemicals with leukoderma-inducible potencies. Thus, this study contributed to environmentology through the development of a screening system for preventing an environmental factor-related disease.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-05-09DOI: 10.1016/j.envpol.2024.123871
James Hall, Jian Zhong, Sue Jowett, Andrea Mazzeo, G Neil Thomas, John R Bryson, Steve Dewar, Nadia Inglis, Mark Wolstencroft, Catherine Muller, William James Bloss, Roy M Harrison, Suzanne E Bartington
Poor air quality is the largest environmental health risk in England. In the West Midlands, UK, ∼2.9 million people are affected by air pollution with an average loss in life expectancy of up to 6 months. The 2021 Environment Act established a legal framework for local authorities in England to develop regional air quality plans, generating a policy need for predictive environmental impact assessment tools. In this context, we developed a novel Air Quality Lifecourse Assessment Tool (AQ-LAT) to estimate electoral ward-level impacts of PM2.5 and NO2 exposure on outcomes of interest to local authorities, namely morbidity (asthma, coronary heart disease (CHD), stroke, lung cancer), mortality, and associated healthcare costs. We apply the Tool to assess the health economic burden of air pollutant exposure and estimate benefits that would be generated by meeting WHO 2021 Global Air Quality Guidelines (AQGs) (annual average concentrations) for NO2 (10 μg/m3) and PM2.5 (5 μg/m3) in the West Midlands Combined Authority Area. All West Midlands residents live in areas which exceed WHO AQGs, with 2070 deaths, 2070 asthma diagnoses, 770 CHD diagnoses, 170 lung cancers and 650 strokes attributable to air pollution exposure annually. Reducing PM2.5 and NO2 concentrations to WHO AQGs would save 10,700 lives reducing regional mortality by 1.8%, gaining 92,000 quality-adjusted life years (QALYs), and preventing 20,500 asthma, 7400 CHD, 1400 lung cancer, and 5700 stroke diagnoses, with economic benefits of £3.2 billion over 20 years. Significantly, we estimate 30% of QALY gains relate to reduced disease burden. The AQ-LAT has major potential to be replicated across local authorities in England and applied to inform regional investment decisions.
{"title":"Regional impact assessment of air quality improvement: The air quality lifecourse assessment tool (AQ-LAT) for the West Midlands combined authority (WMCA) area.","authors":"James Hall, Jian Zhong, Sue Jowett, Andrea Mazzeo, G Neil Thomas, John R Bryson, Steve Dewar, Nadia Inglis, Mark Wolstencroft, Catherine Muller, William James Bloss, Roy M Harrison, Suzanne E Bartington","doi":"10.1016/j.envpol.2024.123871","DOIUrl":"10.1016/j.envpol.2024.123871","url":null,"abstract":"<p><p>Poor air quality is the largest environmental health risk in England. In the West Midlands, UK, ∼2.9 million people are affected by air pollution with an average loss in life expectancy of up to 6 months. The 2021 Environment Act established a legal framework for local authorities in England to develop regional air quality plans, generating a policy need for predictive environmental impact assessment tools. In this context, we developed a novel Air Quality Lifecourse Assessment Tool (AQ-LAT) to estimate electoral ward-level impacts of PM<sub>2.5</sub> and NO<sub>2</sub> exposure on outcomes of interest to local authorities, namely morbidity (asthma, coronary heart disease (CHD), stroke, lung cancer), mortality, and associated healthcare costs. We apply the Tool to assess the health economic burden of air pollutant exposure and estimate benefits that would be generated by meeting WHO 2021 Global Air Quality Guidelines (AQGs) (annual average concentrations) for NO<sub>2</sub> (10 μg/m<sup>3</sup>) and PM<sub>2.5</sub> (5 μg/m<sup>3</sup>) in the West Midlands Combined Authority Area. All West Midlands residents live in areas which exceed WHO AQGs, with 2070 deaths, 2070 asthma diagnoses, 770 CHD diagnoses, 170 lung cancers and 650 strokes attributable to air pollution exposure annually. Reducing PM<sub>2.5</sub> and NO<sub>2</sub> concentrations to WHO AQGs would save 10,700 lives reducing regional mortality by 1.8%, gaining 92,000 quality-adjusted life years (QALYs), and preventing 20,500 asthma, 7400 CHD, 1400 lung cancer, and 5700 stroke diagnoses, with economic benefits of £3.2 billion over 20 years. Significantly, we estimate 30% of QALY gains relate to reduced disease burden. The AQ-LAT has major potential to be replicated across local authorities in England and applied to inform regional investment decisions.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Due to the significance of atmospheric HONO as a reservoir for radicals and the presence of substantial unknown sources of HONO, there is a pressing need for accurate and consistent measurement of its concentration. In this study, we compared the measurements obtained from the monitor for aerosols and gases in ambient air (MARGA) based on wet chemical method with those from the incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS) based on optical method to assess the suitability of the MARGA instrument for accurate HONO detection. The diurnal patterns obtained by the two instruments are similar, with peaks at 8 a.m. and lows at 5 p.m. Over the course of the observation period, it was often observed that HONO concentrations recorded by the MARGA instrument consistently exceeded those obtained through the IBBCEAS technique, accounting for approximately 91.33% of the total observation time. Throughout the entire observation period, the R2 value between the two instruments was 0.49, indicating relatively good correlation. However, with a slope of only 0.27, it suggests poor agreement between the two instruments. Furthermore, the R2 and slopes between the two instruments vary with the seasons and day-night. The larger the quartile values of NO2, NH3, and BC, the greater the slopes of both MARGA and IBBCEAS instruments, and the higher the concentrations of NO2, NH3, and BC (indicator of semivolatile oxidizable hydrocarbons), the greater the differences between the two instruments, all indicating that NH3 may promote the reaction of NO2 with semivolatile oxidizable hydrocarbons to produce HONO. The O3 with its strong oxidizing properties may cause underestimation in the MARGA instrument by oxidizing NO2- to NO3- in the absorbing solution. It is challenging to derive a universal correction formula due to the interference of various chemical substances. Hence, MARGA should not be used for HONO research in the future.
{"title":"The observation of atmospheric HONO by wet-rotating-denuder ion chromatograph in a coastal city: Performance and influencing factors.","authors":"Baoye Hu, Yue Wang, Jinsheng Chen, Naihua Chen, Youwei Hong, Lingling Xu, Xiaolong Fan, Mengren Li, Lei Tong","doi":"10.1016/j.envpol.2024.124355","DOIUrl":"10.1016/j.envpol.2024.124355","url":null,"abstract":"<p><p>Due to the significance of atmospheric HONO as a reservoir for radicals and the presence of substantial unknown sources of HONO, there is a pressing need for accurate and consistent measurement of its concentration. In this study, we compared the measurements obtained from the monitor for aerosols and gases in ambient air (MARGA) based on wet chemical method with those from the incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS) based on optical method to assess the suitability of the MARGA instrument for accurate HONO detection. The diurnal patterns obtained by the two instruments are similar, with peaks at 8 a.m. and lows at 5 p.m. Over the course of the observation period, it was often observed that HONO concentrations recorded by the MARGA instrument consistently exceeded those obtained through the IBBCEAS technique, accounting for approximately 91.33% of the total observation time. Throughout the entire observation period, the R<sup>2</sup> value between the two instruments was 0.49, indicating relatively good correlation. However, with a slope of only 0.27, it suggests poor agreement between the two instruments. Furthermore, the R<sup>2</sup> and slopes between the two instruments vary with the seasons and day-night. The larger the quartile values of NO<sub>2</sub>, NH<sub>3</sub>, and BC, the greater the slopes of both MARGA and IBBCEAS instruments, and the higher the concentrations of NO<sub>2</sub>, NH<sub>3</sub>, and BC (indicator of semivolatile oxidizable hydrocarbons), the greater the differences between the two instruments, all indicating that NH<sub>3</sub> may promote the reaction of NO<sub>2</sub> with semivolatile oxidizable hydrocarbons to produce HONO. The O<sub>3</sub> with its strong oxidizing properties may cause underestimation in the MARGA instrument by oxidizing NO<sub>2</sub><sup>-</sup> to NO<sub>3</sub><sup>-</sup> in the absorbing solution. It is challenging to derive a universal correction formula due to the interference of various chemical substances. Hence, MARGA should not be used for HONO research in the future.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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