Environmental Pollution最新文献_第9页

Pharmaceutical footprint in the river ecosystem: Suspect screening approach with high resolution mass spectrometry 河流生态系统中的药物足迹：高分辨率质谱法可疑筛选方法

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-15 Epub Date: 2026-02-09 DOI: 10.1016/j.envpol.2026.127795

Silvia Royano, Juan Escobar-Arnanz, Irene Navarro, Adrián de la Torre , María Ángeles Martínez

Pharmaceutically active compounds (PhACs) are recognized as important emerging pollutants in aquatic environments. Despite growing concern, an increasing number of new pharmaceuticals are being authorized each year, reaching the environment and compromising the quality and health of ecosystems. However, comprehensive multi-matrix investigations integrating water, sediments, biota, and wastewater systems remain scarce. In this study, a comprehensive HRMS-based suspect screening workflow was implemented using ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-HRMS). Through a multi-compartment approach involving water (n = 89), sediments (n = 28), fish (n = 24), wastewater (n = 16), and sewage sludge (n = 16) matrices collected during 2020-2022, this study identified 153 PhACs (136 active ingredients and 17 metabolites or transformation products). Cardiovascular, psychotropic, pain management, and other nervous system drugs were the dominant therapeutic families, accounting for 63% of all identifications. Surface water contained the highest number of compounds (122), followed by effluents (85). Although influents presented fewer compounds, they showed significantly higher total input (p < 0.05). Solid matrices such as sediments and sludge accumulated highly hydrophobic substances (e.g., telmisartan, citalopram), whereas aqueous matrices contained more polar compounds (e.g., tramadol) and metabolites. Fish exhibited the lowest number of PhACs (11). Regarding spatial distribution, sites more strongly influenced by human activities displayed higher (p < 0.05) normalized areas and number of compounds. Overall, this study provides one of the most comprehensive multi matrix suspect screening assessments of PhACs to date. The holistic evaluation of the riverine ecosystem highlights the value of HRMS based workflows for identifying and prioritizing emerging contaminants, supporting the development of regulatory strategies to control pharmaceutical pollution and enabling early detection of newly marketed drugs.

药物活性化合物（PhACs）是水生环境中重要的新兴污染物。尽管日益引起关注，但每年仍有越来越多的新药获得批准，影响环境并损害生态系统的质量和健康。然而，综合水、沉积物、生物群和废水系统的综合多基质研究仍然很少。在本研究中，采用超高效液相色谱-高分辨率质谱（UPLC-HRMS）实现了基于hrms的嫌疑人筛选工作流程。通过对2020-2022年期间收集的水（n=89）、沉积物（n=28）、鱼（n=24）、废水（n=16）和污水污泥（n=16）基质的多室方法，本研究确定了153种PhACs（136种有效成分和17种代谢物或转化产物）。心血管、精神药物、疼痛治疗和其他神经系统药物是主要的治疗家族，占所有鉴定的63%。地表水含有的化合物最多（122种），其次是污水（85种）。虽然进水中化合物含量较少，但总输入量显著增加（p < 0.05）。固体基质如沉积物和污泥积累了高度疏水性物质（如替米沙坦、西酞普兰），而水基质含有更多极性化合物（如曲马多）和代谢物。鱼类中PhACs的数量最少（11个）。在空间分布上，受人类活动影响越强烈的地点，其归一化面积和化合物数量越高（p < 0.05）。总的来说，这项研究提供了迄今为止最全面的PhACs多矩阵可疑筛查评估之一。河流生态系统的整体评估强调了基于HRMS的工作流程的价值，它可以识别和优先处理新出现的污染物，支持制定控制药物污染的监管战略，并能够早期发现新上市的药物。

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引用次数: 0

Seasonal dynamics, risk prioritization, and management implications for industrial chemicals, pesticides, and PPCPs in the Yangtze River Delta 长江三角洲工业化学品、农药和ppcp的季节性动态、风险优先排序和管理意义

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-24 DOI: 10.1016/j.envpol.2026.127729

Ying Peng , Luhang She , Qiang Xu , Chenyang Sun , Jinzhi Ren , Yining Zhang , Ziqiang Guan , Xiaowei Zhang

This study presents a comprehensive investigation into the occurrence, seasonal variations, and ecological risks of 484 contaminants of emerging concern (CECs) in the surface waters of the Yangtze River Delta. In winter, 209 CECs were detected, with industrial chemicals representing the most dominant category in terms of both concentration and proportion, underscoring industrial discharge as the primary source of pollution in the region. Significant seasonal shifts in contaminant composition were observed: industrial intermediates, surfactants, and antibiotics dominated in winter, whereas industrial intermediates, plasticizers, and herbicides prevailed in summer, reflecting the combined influence of climatic conditions and anthropogenic activities. Spatially, pollution hotspots varied dynamically with the seasons, concentrating in the highly industrialized Yangtze River basin during winter and shifting to the agriculturally intensive Taihu Lake basin in summer. Ecological risk assessment identified 18 high-risk substances, predominantly PPCPs and pesticides, among which the antifungal agent clotrimazole exhibited an extreme hazard quotient (HQ) exceeding 500. A core list of six compounds consistently posed high risks across both seasons. The risk evaluation further revealed pronounced species-specific sensitivity, with Daphnia magna being the most vulnerable, as well as notable seasonal variability, indicating that single-season assessments may underestimate the annual ecological risk. These findings provide a scientific basis for developing targeted region-, risk-, and season-specific management strategies for CECs in the Yangtze River Delta.

本文对长江三角洲表层水体中484种新兴关注污染物的发生、季节变化及生态风险进行了全面调查。在冬季，共检测到209种CECs，其中工业化学品在浓度和比例上都是最主要的类别，突出表明工业排放是该区域的主要污染源。在污染物组成上观察到显著的季节变化：工业中间体、表面活性剂和抗生素在冬季占主导地位，而工业中间体、增塑剂和除草剂在夏季占主导地位，反映了气候条件和人为活动的综合影响。空间上，污染热点随季节动态变化，冬季集中在工业化程度较高的长江流域，夏季向农业密集型的太湖流域转移。生态风险评价确定了18种高危物质，以PPCPs和农药为主，其中抗真菌剂克霉唑的极端危害商（HQ）超过500。六种化合物的核心清单在两个季节都具有很高的风险。风险评价结果显示，大水蚤（Daphnia magna）最为脆弱，且存在明显的季节差异，表明单季节评价可能低估了年生态风险。研究结果可为长三角地区CECs制定针对性区域、风险和季节管理策略提供科学依据。

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引用次数: 0

Radiative effects of dust aerosols and their impacts on precipitation in typical cities surrounding the Taklimakan Desert 塔克拉玛干沙漠周边典型城市沙尘气溶胶辐射效应及其对降水的影响

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.envpol.2025.127584

Guanghui Zhou, Jing Zhang, Xiaoqing Deng, Yiwen Lang, Yifan Wang

Dust aerosols originating from the Taklimakan Desert (TD) significantly affected air quality and the regional climate. In this study, ground-based observations, satellite retrievals, and reanalysis data were integrated to quantitatively assess the aerosol direct radiative effect (ADRE) and its impact on precipitation under different dust pollution levels in four representative cities surrounding the TD – Kashgar, Hotan, Aksu, and Bayingolin. The results indicated that during three periods (09:00–11:00, 12:00–14:00, and 15:00–17:00 Beijing Time – BJT), the magnitude of ADRE for direct, diffuse, total radiation, and diffuse fraction increased with dust pollution intensity, whereas the radiative efficiency decreased. Under certain dust levels, the intensity of the ADRE weakened as surface albedo (SA) and/or the solar zenith angle (SZA) increased. Under all-sky conditions, changes in the radiative energy balance affected the atmospheric thermal structure. From no-dust to mild dust level, the near-surface temperature (1000 hPa) decreased by 4.26, 6.15, and 11.39 °C in Kashgar, Aksu, and Bayingolin, respectively; from mild to heavy dust level, further decreases of 6.73, 5.75, and 5.42 °C occurred, while Hotan experienced a 1.96 °C decrease. As the dust pollution intensified, the lower tropospheric stability (LTS) increased, while water vapor flux (WVF), liquid water path (LWP), cloud droplet effective radius (r_e), and total precipitable water (TPW) decreased, thereby suppressing precipitation. This study would provide additional evidence for understanding the impacts of dust aerosols at varying pollution intensities on the regional radiative energy balance and precipitation.

来自塔克拉玛干沙漠的沙尘气溶胶对空气质量和区域气候有显著影响。本研究利用地面观测、卫星反演和再分析资料，定量评价了青藏高原周边4个典型城市（喀什、和田、阿克苏和巴音戈林）不同沙尘污染水平下气溶胶直接辐射效应（ADRE）及其对降水的影响。结果表明：在北京时间09:00-11:00、12:00-14:00和15:00-17:00 3个时段，直接辐射、漫射辐射、总辐射和漫射分数的ADRE值随扬尘污染强度增大而增大，而辐射效率降低；在一定扬尘水平下，ADRE的强度随地表反照率（SA）和太阳天顶角（SZA）的增大而减弱。在全天条件下，辐射能量平衡的变化影响了大气热结构。从无尘到轻度扬尘，喀什、阿克苏和巴音戈林近地表温度（1000 hPa）分别下降4.26、6.15和11.39℃；从轻度到重度，分别下降了6.73、5.75、5.42℃，和田下降了1.96℃。随着沙尘污染的加剧，对流层低层稳定性（LTS）增加，水汽通量（WVF）、液态水路径（LWP）、云滴有效半径（re）和总可降水量（TPW）减少，从而抑制降水。该研究将为了解不同污染强度下粉尘气溶胶对区域辐射能量平衡和降水的影响提供额外的证据。

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引用次数: 0

Occurrence and distribution of phthalate esters in stormwater runoff and coastal water receiving bodies, Macao, South China 华南澳门雨水径流及沿岸水体中邻苯二甲酸酯的发生与分布

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1016/j.envpol.2026.127742

Yutang Luo , Tianyi Zhang , Yaru Cao , Qiying Jian , Aolei Du , Jun Yan , Yanjun Li , Youxiang Xu , Guoyuan Zhu , Xiong Xiong , Chenxi Wu , Kai Zhang

Urban stormwater runoff is a major pathway for anthropogenic pollutants into aquatic ecosystems. Phthalate esters (PAEs), widely produced endocrine-disrupting plasticizers, readily enter the environment; however, their transport via stormwater and contribution to nearshore marine pollution remain largely overlooked. The stormwater system of Macao discharges directly to the sea, representing a potentially significant PAE pathway, yet systematic investigations on PAEs pollution in its aquatic environment are lacking. This study conducted the first comprehensive investigation on the occurrence and distribution of 16 PAEs congeners in six stormwater drainage channels (covering residential, industrial, and ecological functional zones) and four seawater sampling sites in Macao using GC-MS, aiming to characterize PAEs pollution, identify sources, and estimate annual fluxes. Results showed widespread PAEs contamination: Σ₁₆PAEs in stormwater ranged from 1.51 × 10²–3.35 × 10⁴ ng/L (0.152–33.5 μg/L), and 89.1–858 ng/L in seawater. High levels of dimethoxyethyl phthalate (DMEP) were detected, revealing unique local pollution characteristics. Among stormwater sites, Σ₁₆PAEs loads were significantly higher in residential/industrial areas than ecological areas, with distinct seasonal variations. Linear correlations between some stormwater and seawater PAEs concentrations may imply a potential source-sink relationship. Principal component analysis indicated non-point sources primarily from residential and industrial discharges. Importantly, pumping stations were innovatively identified as key dry-season PAEs sources. The annual average Σ₁₆PAEs input from the stormwater system of Macao to nearshore waters was 4.31 × 10⁻³–9.5 kg. As the first systematic report on aquatic PAEs pollution of Macao, these findings fill the regional research gap, support targeted dry/wet season control measures, and provide a reference for small coastal cities.

城市雨水径流是人为污染物进入水生生态系统的主要途径。邻苯二甲酸酯（PAEs）是广泛生产的干扰内分泌的增塑剂，很容易进入环境；然而，它们通过雨水的运输和对近岸海洋污染的贡献在很大程度上被忽视了。澳门雨水系统直接向海洋排放，是一条潜在的重要PAE途径，但缺乏对其水环境中PAEs污染的系统调查。本研究首次利用气相色谱-质谱联用技术，对澳门6个雨水排水通道（包括住宅、工业和生态功能区）和4个海水采样点的16种PAEs同系物的发生和分布进行了全面调查，目的是表征PAEs污染，确定其来源，估算其年通量。结果表明，PAEs污染范围广泛，雨水中Σ16PAEs范围为from1.51×102-3.35×104 ng/L (0.152 ~ 33.5 μg/L)，海水中为89.1 ~ 858 ng/L。检测到高浓度的邻苯二甲酸二甲氧基乙酯（DMEP），揭示了当地独特的污染特征。在雨水站点中，住宅/工业区的Σ16PAEs负荷显著高于生态区，且具有明显的季节变化。一些雨水和海水PAEs浓度之间的线性相关可能意味着潜在的源-汇关系。主成分分析表明，非点源主要来自居民和工业排放。重要的是，泵站被创新地确定为旱季PAEs的主要来源。澳门雨水系统向近岸水域的年平均Σ16PAEs输入量为4.31×10-3-9.5公斤。本研究结果为澳门首个系统报告水体PAEs污染情况，填补了区域研究空白，支持有针对性的干湿季控制措施，为沿海小城市提供参考。

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引用次数: 0

The contributions of refined anthropogenic sources to PM2.5 air quality and health impacts in China from 2020 to 2030, and associated policy benefits 2020 - 2030年中国精细人为源对PM2.5空气质量和健康影响的贡献及相关政策效益

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-30 DOI: 10.1016/j.envpol.2026.127743

Ruili Wu , Xinying Qin , Hongyan Zhao , Jing Cheng , Shigan Liu , Christopher W. Tessum , Qiang Zhang

In this study, we quantified the contributions of twenty-three emission sectors to ambient PM_2.5 concentrations and associated premature deaths in China from 2020 to 2030 using three key components: 1) a China-specific reduced-complexity air quality model, 2) high-resolution emission data for refined sectors, and 3) the exposure-response function (ERF) from the Global Exposure Mortality Model (GEMM). Our findings indicate that the implementation of end-of-pipe control policies and energy policies would lead to a reduction in the nationwide population-weighted PM_2.5 concentration from 41.2 μg/m³ to 26.3 μg/m³ between 2020 and 2030, with the largest contributor shifting from residential biomass burning to off-road mobile machinery during this period. Correspondingly, annual PM_2.5-related premature deaths are projected to decline from 1.8 million to 1.2 million, with the primary contributor to mortality shifting from residential biomass burning to coal-fired power plants. Notably, relative to the business-as-usual (BAU) scenario, these policies are expected to yield substantial co-benefits by 2030, including a reduction of 30.2 μg/m³ in population-weighted PM_2.5 concentration and the annual avoidance of 1.3 million premature deaths. Key policies driving these significant improvements in PM_2.5 levels and public health include: increasing the proportion of renewable energy in power generation; tightening emission standards and phasing out outdated coal-fired industrial boilers, cement plants, and iron and steel facilities; replacing residential coal consumption; controlling emissions from coal-fired heating plants; and upgrading emission standards for on-road diesel trucks and off-road mobile machinery.

在这项研究中，我们使用三个关键组成部分量化了2020年至2030年中国23个排放部门对环境PM2.5浓度和相关过早死亡的贡献：1)中国特定的低复杂性空气质量模型，2)精炼部门的高分辨率排放数据，以及3)全球暴露死亡率模型（GEMM）的暴露响应函数（ERF）。研究结果表明，2020 - 2030年，终端控制政策和能源政策的实施将导致全国人口加权PM2.5浓度从41.2 μg/m3降至26.3 μg/m3，其中最大的贡献者从住宅生物质燃烧转向越野移动机械。相应地，预计每年与pm2.5相关的过早死亡人数将从180万下降到120万，导致死亡的主要原因将从住宅生物质燃烧转向燃煤发电厂。值得注意的是，相对于“一切照旧”情景，这些政策预计到2030年将产生巨大的协同效益，包括人口加权PM2.5浓度降低30.2 μg/m3，每年避免130万人过早死亡。推动PM2.5水平和公众健康显著改善的关键政策包括：提高可再生能源在发电中的比例；严格排放标准，淘汰落后的燃煤工业锅炉、水泥、钢铁设施；替代居民煤炭消费；控制燃煤供热厂的排放；提高公路柴油车和非公路移动机械排放标准。

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引用次数: 0

Prenatal exposure to multiple insecticides and reduced birth weight: a possible mediating role of plasma metabolomic alterations 产前暴露于多种杀虫剂和降低出生体重：血浆代谢组学改变的可能中介作用

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.envpol.2026.127755

Juan Wen , Junya Wang , Juan Mu , Yue Zhang , Miao Miao , Lingmin Hu , Yongmei Dai , Haiting Hu

Organophosphates (OPPs), pyrethroids (PYRs), and neonicotinoids (NNIs) represent three major classes of insecticides with potential developmental toxicity, yet their effects on fetal growth remain insufficiently characterized. This prospective cohort study examined 442 maternal-infant pairs from Jiangsu, China to assess the relationship between prenatal insecticide exposure and birth outcomes, while exploring underlying metabolomic mechanisms. Maternal fasting blood samples obtained during early pregnancy (<16 weeks) were analyzed for 15 insecticides/their metabolites (3 OPPs, 3 PYRs, and 9 NNIs) and 495 metabolomic features. Fetal growth parameters were assessed via ultrasound-estimated fetal weight and birth measurements from medical records. Multiple linear regression revealed that each natural log-unit rise in 3,5,6-trichloro-2-pyridinol (TCPy, an OPP metabolite) and desmethyl-clothianidin (DM-CLO, an NNI metabolite) concentrations was linked to a significant reduction in birth weight by 43.75 g (95% CI: 73.27, −14.23) and 68.45 g (95% CI: 121.98, −14.92), respectively. Mixture analysis through weighted quantile sum (WQS) regression demonstrated that exposure to insecticide mixture was related to a 122.15 g reduction in birth weight (95% CI: 187.83, −56.47), with TCPy and DM-CLO identified as primary contributors. Metabolomic analysis identified 14 metabolites significantly linked to both insecticide exposure and birth weight, and pathway analysis revealed significant enrichment in "Valine, leucine and isoleucine biosynthesis" (P < 0.001). Mediation analysis indicated that ketoleucine and 3-Methyl-2-oxovaleric acid mediated 9.86% and 6.78% of the insecticides-birth weight association, respectively. These findings suggest that prenatal exposure to specific OPP and NNI metabolites is associated with reduced birth weight, potentially mediated through disruption of branched-chain amino acid metabolism.

有机磷酸酯（OPPs）、拟除虫菊酯（PYRs）和新烟碱类（NNIs）是三大类具有潜在发育毒性的杀虫剂，但它们对胎儿生长的影响尚未得到充分的研究。这项前瞻性队列研究调查了来自中国江苏的442对母婴，以评估产前杀虫剂暴露与出生结局之间的关系，同时探索潜在的代谢组学机制。在妊娠早期（16周）采集的孕妇空腹血样中分析了15种杀虫剂/其代谢物（3种OPPs， 3种PYRs和9种NNIs）和495种代谢组学特征。通过超声估计胎儿体重和医疗记录中的出生测量来评估胎儿生长参数。多元线性回归显示，3,5,6-三氯-2-吡啶醇（TCPy，一种OPP代谢物）和去甲基-噻虫胺（DM-CLO，一种NNI代谢物）浓度每增加一个自然对数单位，出生体重分别显著减少43.75 g （95% CI: 73.27,−14.23）和68.45 g （95% CI: 121.98,−14.92）。通过加权分位数和（WQS）回归的混合分析表明，暴露于杀虫剂混合物与出生体重减少122.15 g有关（95% CI: 187.83,−56.47），TCPy和DM-CLO被确定为主要因素。代谢组学分析发现14种代谢物与杀虫剂暴露和出生体重显著相关，途径分析显示“缬氨酸、亮氨酸和异亮氨酸生物合成”显著富集（P < 0.001）。中介分析表明，酮丙氨酸和3-甲基-2-氧戊酸分别介导了9.86%和6.78%的杀虫剂与出生体重的关联。这些发现表明，产前暴露于特定的OPP和NNI代谢物与出生体重降低有关，可能通过破坏支链氨基酸代谢介导。

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引用次数: 0

Brain concentrations of flame retardants and trace elements related to habitat use and brain measures in an urban-adapted gull 城市适应海鸥的阻燃剂和微量元素脑浓度与栖息地使用和脑测量有关。

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.envpol.2026.127726

Anna Lippold , Mélanie F. Guigueno , Marilou Lalumière , Chavy Dworkind , Alison Aube , Amy Smith-Dijak , Brenda Toscano-Marquez , Anna A. Cook , Alanna J. Watt , Jonathan Verreault

Exposure to environmental contaminants, such as halogenated flame retardants (HFRs) and trace elements, has been associated with a several health effects, including neurotoxicity. However, information on contaminant concentrations in brain tissue and factors influencing their accumulation and exposure-related effects are limited in wild birds. We quantified 45 HFRs and 16 trace elements in brain of ring-billed gulls (Larus delawarensis) breeding in a highly urbanized environment and related their concentrations to foraging habitat use and a range of coarse and fine-scale neuroanatomical measures. Ten polybrominated diphenyl ethers (PBDEs), hexabromobenzene (HBB), pentabromoethylbenzene (PBEB), and anti-dechlorane plus (anti-DP) were detected in over 80 % of brain samples, as well as cobalt, nickel, copper, selenium, silver, cadmium, lead, and mercury. For certain compounds or elements, brain concentrations correlated with foraging habitat use, for example, PBDEs and lead increased with the proportion of time gulls spent foraging in waste management facilities. Additionally, we found correlations between brain contaminant concentrations and certain brain measures. For example, the number of immature neurons in the nucleus pretectalis principalis (Pt), a region in the visual system in birds, correlated negatively with brain concentrations of PBDEs and lead. Our results showed that urban-adapted ring-billed gulls accumulate a wide range of HFRs and trace elements in brain tissue, and that some of these contaminants might be associated with variations in selected neural measures. Although the present correlative study cannot establish causality, these findings highlight potential toxicity pathways in the avian brain that warrant mechanistic investigation under controlled conditions.

接触环境污染物，如卤代阻燃剂和微量元素，与若干健康影响有关，包括神经毒性。然而，关于野生鸟类大脑中的污染物浓度以及影响其积累和接触相关影响的因素的信息有限。本研究量化了在高度城市化环境中繁殖的环嘴鸥（Larus delawarensis）脑中的45种HFRs和16种微量元素，并将其浓度与觅食栖息地的利用和一系列粗、精细神经解剖学测量相关联。在超过80%的脑样本中检测到十种多溴二苯醚（PBDEs）、六溴苯（HBB）、五溴乙苯（PBEB）和反二氯烷（anti-DP），以及钴、镍、铜、硒、银、镉、铅和汞。对于某些化合物或元素，大脑浓度与觅食栖息地的使用有关，例如，多溴二苯醚和铅随着海鸥在废物管理设施中觅食的时间比例的增加而增加。此外，我们还发现了脑污染物浓度与某些脑测量指标之间的相关性。例如，鸟的视觉系统区域——主前核（Pt）中未成熟神经元的数量与脑内多溴二苯醚和铅的浓度呈负相关。我们的研究结果表明，适应城市的环嘴鸥在大脑中积累了广泛的HFRs和微量元素，其中一些污染物可能与选择的神经测量的变化有关。虽然目前的相关研究不能确定因果关系，但这些发现强调了鸟类大脑中潜在的毒性途径，需要在受控条件下进行机制研究。

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引用次数: 0

EBV-driven rewiring of Drp1-Mediated mitophagy exacerbates trichloroethylene-induced hypersensitivity syndrome ebv驱动的drp1介导的线粒体自噬重新布线加剧了三氯乙烯诱导的超敏综合征。

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-20 DOI: 10.1016/j.envpol.2026.127716

Yuyan Xu , Shuai Liu , Mengnan Yi , Wen Gu , Yican Wang , Guoyong Mei , Jun Han , Yufei Dai

The environmental pollutant trichloroethylene (TCE) can induce T-cell-mediated hypersensitivity syndrome. Clinical evidence closely links Epstein-Barr virus (EBV) reactivation to aggravated disease severity, yet the mechanism underlying this chemical-viral synergy remains unknown. Based on the view that hypersensitivity essentially involves sustained activation of effector T-cells and disruption of immune homeostasis, this study aims to investigate how EBV reactivation cooperates with TCE metabolite trichloroethanol (TCOH) to regulate the T-cell apoptosis process by affecting mitochondrial dynamics and autophagy, thereby exacerbating trichloroethylene-induced hypersensitive syndrome (TIHS). Results show that TCOH exposure induces mitochondrial damage and apoptosis in T-cells. However, co-exposure with EBV significantly alleviates TCOH-induced mitochondrial damage by enhancing Drp1-mediated mitochondrial fission and promoting subsequent PINK1/Parkin pathway-dependent mitophagy, which in turn suppresses T-cell apoptosis. In an animal model, administration of the Drp1 inhibitor Mdivi-1 inhibited mitophagy, increased T-cell apoptosis, and effectively alleviated skin and hepatic immune injury in TCE-sensitized mice. This confirms that Drp1 is a key molecular target regulating the T-cell apoptosis program and influencing the progression of TIHS. The study reveals that during TIHS development, EBV reactivation exploits Drp1 to promote mitochondrial fission and mitophagy, thereby hindering the normal apoptotic clearance of activated effector T-cells, leading to their sustained activation and immune attack, which exacerbates tissue inflammation and injury. This finding provides a new scientific perspective for understanding the mechanism by which viral co-exposure aggravates TIHS.

环境污染物三氯乙烯（TCE）可诱发t细胞介导的过敏综合征。临床证据与eb病毒（EBV）再激活与疾病严重程度加重密切相关，但这种化学-病毒协同作用的机制尚不清楚。基于超敏反应本质上涉及效应t细胞的持续激活和免疫稳态的破坏，本研究旨在探讨EBV再激活如何与TCE代谢物三氯乙醇（TCOH）协同作用，通过影响线粒体动力学和自噬来调节t细胞凋亡过程，从而加剧三氯乙烯诱导的超敏综合征（TIHS）。结果表明，TCOH暴露可诱导t细胞线粒体损伤和凋亡。然而，与EBV共暴露可通过增强drp1介导的线粒体分裂和促进随后的PINK1/Parkin途径依赖的线粒体自噬，从而抑制t细胞凋亡，从而显著减轻tcoh诱导的线粒体损伤。在动物模型中，给药Drp1抑制剂Mdivi-1可抑制线粒体自噬，增加t细胞凋亡，有效减轻tce致敏小鼠的皮肤和肝脏免疫损伤。这证实了Drp1是调控t细胞凋亡程序并影响TIHS进展的关键分子靶点。研究发现，在TIHS发育过程中，EBV再激活利用Drp1促进线粒体分裂和线粒体自噬，从而阻碍活化效应t细胞的正常凋亡清除，导致效应t细胞持续活化和免疫攻击，加剧组织炎症和损伤。这一发现为理解病毒共暴露加重TIHS的机制提供了新的科学视角。

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引用次数: 0

Procymidone induces muscle atrophy and impaired myocyte fusion via the TNF-α/NF-κB/ROS pathway in developing zebrafish embryos 原胺酮通过TNF-α/NF-κB/ROS通路诱导斑马鱼胚胎发育中的肌肉萎缩和肌细胞融合受损。

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-02-02 DOI: 10.1016/j.envpol.2026.127760

Chuanwen Yin , Suwen Zeng , Yuyang Peng , Xiaomei Chen , Yong Huang , Xin Yang , Ling Liu , Minhong Zhang , Huiqiang Lu

Procymidone (PCM), a fungicide widely used to control gray mold and Sclerotinia rot in agricultural production, is known for its hepatotoxic and endocrine-disrupting effects; however, its potential myotoxicity remains largely unexplored. To evaluate muscle toxicity and underlying mechanisms, zebrafish embryos were exposed to PCM (1, 1.25, 1.5 mg/L) until 72 h post-fertilization (hpf). Transgenic models revealed that PCM exposure was associated with myopathic phenotypes, including muscle atrophy and aberrant muscle cell fusion. Transcriptomic analysis identified extensive dysregulation of genes involved in muscle development, differentiation, fusion, and motor function. PCM exposure was accompanied by increased reactive oxygen species (ROS) levels and elevated apoptosis in affected tissues. Gene Set Enrichment Analysis (GSEA) suggested enrichment of Toll-like receptor and apoptosis signaling pathways, which have been associated with muscle atrophy. Integrative analyses suggested that PCM-induced muscular toxicity is associated with coordinated alterations in TNF-α/NF-κB signaling and oxidative stress. Notably, co-treatment with an NF-κB inhibitor partially alleviated PCM-induced muscle atrophy. Together, these findings indicate that PCM exposure induces muscular toxicity in developing zebrafish, which is associated with oxidative stress and inflammation-related apoptotic responses. This study provides mechanistic insight into procymidone-associated skeletal muscle toxicity and contributes to the understanding of its potential impacts on aquatic organisms.

Procymidone （PCM）是一种广泛用于农业生产中防治灰霉病和菌核病的杀菌剂，因其肝毒性和内分泌干扰作用而闻名；然而，其潜在的肌毒性在很大程度上仍未被探索。为了评估肌肉毒性及其潜在机制，斑马鱼胚胎暴露于PCM （1,1.25, 1.5 mg/L）直到受精后72小时（hpf）。转基因模型显示PCM暴露与肌病表型相关，包括肌肉萎缩和异常的肌肉细胞融合。转录组学分析确定了与肌肉发育、分化、融合和运动功能有关的基因的广泛失调。PCM暴露伴随着受影响组织中活性氧（ROS）水平的增加和细胞凋亡的升高。基因集富集分析（GSEA）表明toll样受体和凋亡信号通路的富集与肌肉萎缩有关。综合分析表明，pcm诱导的肌肉毒性与TNF-α/NF-κB信号和氧化应激的协调改变有关。值得注意的是，与NF-κB抑制剂联合治疗可部分缓解pcm诱导的肌肉萎缩。总之，这些发现表明PCM暴露会诱导发育中的斑马鱼肌肉毒性，这与氧化应激和炎症相关的凋亡反应有关。本研究提供了原嘧啶酮相关骨骼肌毒性的机制，并有助于了解其对水生生物的潜在影响。

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引用次数: 0

Comparative ecotoxicity of a reduced graphene–polypropylene nanocomposite and its components to the terrestrial isopod Porcellio scaber (Crustacea) 还原性石墨烯-聚丙烯纳米复合材料及其组分对陆生等足类动物瓷爪虫的生态毒性比较

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution

Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.envpol.2026.127756

Sara Novak , Andraž Dolar , Tina Petrišič , Valentina Perc , Julio Gomez , Elvira Villaro , Monica Martinez-Junquera , Carlota Eguiluz García , Mateja Štefančič , Damjana Drobne

Graphene-enhanced polymer composites are attracting interest due to the unique properties of graphene-related nanomaterials. However, their environmental impact, especially as sources of micro- and nanoplastics (MNPs), remains underexplored compared to conventional polymers. Therefore, comprehensive environmental risk assessments of advanced polymer nanocomposites are needed. This study assessed the toxic potential of reduced graphene oxide-enhanced polypropylene (PP-rGO) using a multi-biomarker approach, focusing on how rGO alters the ecotoxicological profile of polypropylene (PP).

Terrestrial isopods were exposed for 14 days to soil mixed with PP and PP-rGO MNPs at 1% and 10% w/w, and to reduced graphene oxide (rGO) alone at 0.1% and 1% w/w. The lowest tested concentrations represent environmentally relevant levels of MNPs in soil, while the highest concentrations reflect a worst-case scenario. Organism-level toxicity was evaluated by monitoring survival, body weight change, and moulting frequency. Sublethal stress responses were evaluated in isolated isopod haemolymph using cellular and biochemical biomarkers, including haemocyte counts, haemocyte viability, and phenoloxidase-like activity. In addition, electron transport system activity, glutathione S-transferase activity, and acetylcholinesterase activity were assessed in whole-animal homogenates. At 1%, PP-rGO triggered sublethal stress without affecting survival. At 10%, it caused low toxicity and altered haemocyte profiles. rGO induced high toxicity at 1%, impacting survival and moulting. PP alone caused stress only at 10%. Embedding rGO in a polymer matrix reduces its toxicity compared to free rGO but still enhances PP effects. These findings highlight the need for thorough environmental risk assessment of nanocomposites.

石墨烯增强聚合物复合材料因其纳米材料的独特性能而备受关注。然而，与传统聚合物相比，它们对环境的影响，特别是作为微塑料和纳米塑料（MNPs）的来源，仍然没有得到充分的研究。因此，需要对先进聚合物纳米复合材料进行全面的环境风险评价。本研究使用多生物标志物方法评估了还原氧化石墨烯增强聚丙烯（PP-rGO）的毒性潜力，重点研究了rGO如何改变聚丙烯（PP）的生态毒理学特征。将陆生等足类动物暴露在含有PP和PP-rGO MNPs的土壤中，分别以1%和10%的w/w，以及0.1%和1% w/w的还原氧化石墨烯（rGO）中，持续14天。最低测试浓度代表土壤中MNPs的环境相关水平，而最高浓度反映最坏情况。通过监测存活率、体重变化和换羽频率来评估生物水平的毒性。使用细胞和生化生物标志物，包括血细胞计数、血细胞活力和酚氧化酶样活性，评估分离的等足类血淋巴的亚致死应激反应。此外，在全动物匀浆中评估了电子传递系统活性、谷胱甘肽s转移酶活性和乙酰胆碱酯酶活性。在1%时，PP-rGO触发亚致死应激，但不影响生存。当浓度为10%时，其毒性较低，并能改变血细胞谱。1%的氧化石墨烯产生高毒性，影响存活和换毛。只有10%的人因为PP而感到压力。与游离氧化石墨烯相比，在聚合物基质中嵌入氧化石墨烯可降低其毒性，但仍可增强PP效应。这些发现强调了对纳米复合材料进行全面环境风险评估的必要性。

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引用次数: 0