首页 > 最新文献

Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference最新文献

英文 中文
Evaluation of in vitro drug release and in vivo tolerance of porous biodegradable reservoir device 多孔可生物降解储药器体外释药及体内耐受性评价
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514418
D. Yang, G. Peyman, K. Fillacier, B. Khoobehi
The biodegradable polymer polycaprolactone was tested in vitro and in vivo as an intraocular drug delivery device loaded with 5-carboxyfluorescein dye. Zero-order release of carboxyfluorescein was obtained in vitro. The device was tolerated well after implantation in the rabbit eye. Further studies are necessary to determine the efficacy of this form of drug delivery.
采用生物可降解聚合物聚己内酯作为负载5-羧基荧光素染料的眼内给药装置进行了体外和体内试验。羧基荧光素在体外获得零级释放。该装置植入兔眼后耐受性良好。需要进一步的研究来确定这种给药方式的有效性。
{"title":"Evaluation of in vitro drug release and in vivo tolerance of porous biodegradable reservoir device","authors":"D. Yang, G. Peyman, K. Fillacier, B. Khoobehi","doi":"10.1109/SBEC.1995.514418","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514418","url":null,"abstract":"The biodegradable polymer polycaprolactone was tested in vitro and in vivo as an intraocular drug delivery device loaded with 5-carboxyfluorescein dye. Zero-order release of carboxyfluorescein was obtained in vitro. The device was tolerated well after implantation in the rabbit eye. Further studies are necessary to determine the efficacy of this form of drug delivery.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127366086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Water and filler content of hybrid glass ionomers 杂化玻璃离子的水和填料含量
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514444
B. Roberts, A. Puckett, B. Bennett
Summary form only given. The objective of this study was to determine the water and filler content of five different hybrid glass ionomers (GI) after aging in distilled water at 37 /spl deg/C for 7 days. The materials were A.) Encapsulated and B.) hand mixed Variglass (Caulk Dentsply, Milford, DE) C.) Photacfil Aplicaps (ESPE Premier, Norristown, PA) D.) Fuji II capsules (GC corp., Tokyo, Japan) and E.) Vitremer (3M, St. Paul, MN). Based upon the mass loss with increasing temperature and the residual mass, the percent water and filler content of the materials were determined. Comparison of the results using ANOVA and the Tukey test (p <.05) reveals that the water content is significantly different for every material and the filler contents are different for every material except C and D.
只提供摘要形式。本研究的目的是测定5种不同的杂化玻璃离子(GI)在37 /spl℃蒸馏水中陈化7天后的水分和填料含量。材料是a。封装和b)手工混合varigglass (Caulk Dentsply, Milford, DE) c)摄影应用(ESPE Premier, Norristown, PA) D.)富士II胶囊(日本东京GC公司)Vitremer (3M, St. Paul, MN)。根据随温度升高的质量损失和残余质量,确定了材料的含水率和填料含量。方差分析和Tukey检验结果比较(p < 0.05)表明,除C和D外,每种材料的含水量差异显著,填充物含量也不同。
{"title":"Water and filler content of hybrid glass ionomers","authors":"B. Roberts, A. Puckett, B. Bennett","doi":"10.1109/SBEC.1995.514444","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514444","url":null,"abstract":"Summary form only given. The objective of this study was to determine the water and filler content of five different hybrid glass ionomers (GI) after aging in distilled water at 37 /spl deg/C for 7 days. The materials were A.) Encapsulated and B.) hand mixed Variglass (Caulk Dentsply, Milford, DE) C.) Photacfil Aplicaps (ESPE Premier, Norristown, PA) D.) Fuji II capsules (GC corp., Tokyo, Japan) and E.) Vitremer (3M, St. Paul, MN). Based upon the mass loss with increasing temperature and the residual mass, the percent water and filler content of the materials were determined. Comparison of the results using ANOVA and the Tukey test (p <.05) reveals that the water content is significantly different for every material and the filler contents are different for every material except C and D.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131441326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wavelet transformation of chaotic biological signals 混沌生物信号的小波变换
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514474
Bai-lian Li, Hsin-i Wu
Wavelet analysis is a recently developed mathematical theory and computational method for decomposing a nonstationary signal into components that have good localization properties both in time and frequency and hierarchical structures. Wavelet transform provides local information and multiresolution decomposition on a signal that cannot be obtained using traditional methods such as Fourier transforms and statistical estimation theory. Hence the change in complex biological signals can be detected. We use wavelet analysis as an innovative method for identifying and characterizing chaotic biological signals in this paper. We usually do not know the underlying mechanism that determine the behavior of a biosystem. We are instead presented with nothing more than a phenomenological time series signal of the behavior, and must infer the mechanism from simple measurements of that time series. Data we used are simulated chaotic signals from the logistic equation. Using wavelet transformation we extract instantaneous frequencies of the signal varying in time across scales. The results under different parameters and initial conditions show that the phase maps of their wavelet transforms are different between period doubling bifurcation and chaos. This information could be used as a diagnostic for detecting different nonlinear dynamic responses. This may lead to a better understanding of the system, that may allow us to predict the onset of lethal arrhythmias and to intervene prior to the development of catastrophic clinical events.
小波分析是近年来发展起来的一种数学理论和计算方法,用于将非平稳信号分解成在时间、频率和层次结构上都具有良好局域性的分量。小波变换提供了傅里叶变换和统计估计等传统方法无法获得的信号的局部信息和多分辨率分解。因此,复杂生物信号的变化可以被检测到。本文将小波分析作为一种创新的方法用于混沌生物信号的识别和表征。我们通常不知道决定生物系统行为的潜在机制。相反,我们得到的只是行为的现象学时间序列信号,并且必须从该时间序列的简单测量中推断出机制。我们使用的数据是来自logistic方程的模拟混沌信号。利用小波变换提取信号在不同尺度上随时间变化的瞬时频率。在不同参数和初始条件下的结果表明,它们的小波变换在倍周期分岔和混沌时的相位映射是不同的。这些信息可以作为检测不同非线性动态响应的诊断。这可能会使我们更好地了解这个系统,这可能使我们能够预测致命性心律失常的发作,并在灾难性临床事件发生之前进行干预。
{"title":"Wavelet transformation of chaotic biological signals","authors":"Bai-lian Li, Hsin-i Wu","doi":"10.1109/SBEC.1995.514474","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514474","url":null,"abstract":"Wavelet analysis is a recently developed mathematical theory and computational method for decomposing a nonstationary signal into components that have good localization properties both in time and frequency and hierarchical structures. Wavelet transform provides local information and multiresolution decomposition on a signal that cannot be obtained using traditional methods such as Fourier transforms and statistical estimation theory. Hence the change in complex biological signals can be detected. We use wavelet analysis as an innovative method for identifying and characterizing chaotic biological signals in this paper. We usually do not know the underlying mechanism that determine the behavior of a biosystem. We are instead presented with nothing more than a phenomenological time series signal of the behavior, and must infer the mechanism from simple measurements of that time series. Data we used are simulated chaotic signals from the logistic equation. Using wavelet transformation we extract instantaneous frequencies of the signal varying in time across scales. The results under different parameters and initial conditions show that the phase maps of their wavelet transforms are different between period doubling bifurcation and chaos. This information could be used as a diagnostic for detecting different nonlinear dynamic responses. This may lead to a better understanding of the system, that may allow us to predict the onset of lethal arrhythmias and to intervene prior to the development of catastrophic clinical events.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124938736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A model-based reasoning system for the management of respiratory weaning process 基于模型的呼吸脱机过程管理推理系统
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514417
Qian Tan, S. Napper
Summary form only given. The progressive withdrawal of mechanical ventilation is called weaning. A computerized decision support system (off-line or on-line) would help the medical staff to wean patients more efficiently and can potentially reduce treatment duration and mortality rates. The aim of this research is to design a model-based reasoning system to provide on-line guidance in respiratory weaning process management. In this approach, the semi-quantitative reasoning method is applied to regulate and control the weaning process by adjusting the ventilator settings. A semi-quantitative method provides a level of description that is intermediate between abstract qualitative models and precise numerical models. It combines both qualitative and quantitative knowledge within a single semi-quantitative qualitative differential equation (SQDE) representation. It is a set of qualitative constraints which are augmented with envelopes for all monotonic functions and numeric ranges for all model variables and initial conditions. The model is then simulated to compute the variables in ventilator setting. The control system is tested under different physiological conditions, using a detailed simulation model of the human respiratory system.
只提供摘要形式。逐步停用机械通气称为脱机。计算机化决策支持系统(离线或在线)将帮助医务人员更有效地让患者断奶,并可能缩短治疗时间和死亡率。本研究的目的是设计一个基于模型的推理系统,为呼吸脱机过程管理提供在线指导。该方法采用半定量推理方法,通过调节呼吸机设置来调节和控制断奶过程。半定量方法提供了介于抽象的定性模型和精确的数值模型之间的描述层次。它将定性和定量知识结合在一个半定量定性微分方程(SQDE)表示中。它是一组定性约束,对所有单调函数和所有模型变量和初始条件的数值范围进行包络扩充。然后对模型进行仿真,计算出通风机设置的变量。利用人体呼吸系统的详细仿真模型,在不同的生理条件下对控制系统进行了测试。
{"title":"A model-based reasoning system for the management of respiratory weaning process","authors":"Qian Tan, S. Napper","doi":"10.1109/SBEC.1995.514417","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514417","url":null,"abstract":"Summary form only given. The progressive withdrawal of mechanical ventilation is called weaning. A computerized decision support system (off-line or on-line) would help the medical staff to wean patients more efficiently and can potentially reduce treatment duration and mortality rates. The aim of this research is to design a model-based reasoning system to provide on-line guidance in respiratory weaning process management. In this approach, the semi-quantitative reasoning method is applied to regulate and control the weaning process by adjusting the ventilator settings. A semi-quantitative method provides a level of description that is intermediate between abstract qualitative models and precise numerical models. It combines both qualitative and quantitative knowledge within a single semi-quantitative qualitative differential equation (SQDE) representation. It is a set of qualitative constraints which are augmented with envelopes for all monotonic functions and numeric ranges for all model variables and initial conditions. The model is then simulated to compute the variables in ventilator setting. The control system is tested under different physiological conditions, using a detailed simulation model of the human respiratory system.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123866973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pathologic processes associated with the use of scleral buckling in humans 与人类使用巩膜屈曲相关的病理过程
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514463
R. Misra
Scleral buckling or indentation over a retinal tear or detachment was popularized by Ernst Custodis in 1953. Since then it has become one of the most popular and effective retinal reattachment surgical procedures. Although a few biologic materials such as fascia lata, lyophilized sclera and gelatin are used sometimes as scleral buckles, the most common material for buckles currently used is derivatives of medical grade silicone rubber or MAI. When the scleral buckling material is of foreign origin, the body reacts with acute and chronic inflammation, extrusion, and intrusion. The author has studied five eneucleated globes, with scleral buckles in place for periods of 3 to 48 months. The globes were removed for "painful blind eyes". The author's studies consisted of histomorphological analyses. The author observed foreign body granulomatous reaction and extensive fibrosis of Tenon's capsule and the sclera. The precise mechanism by which scleral buckling works remain uncertain at this time.
1953年恩斯特·库斯托迪斯推广了视网膜撕裂或脱离的巩膜屈曲或压痕。从那时起,它已成为最流行和最有效的视网膜再植手术方法之一。虽然一些生物材料如阔筋膜、冻干巩膜和明胶有时被用作巩膜扣,但目前使用的最常见的扣材是医用级硅橡胶或MAI的衍生物。当巩膜屈曲材料是外来来源时,机体反应为急性和慢性炎症、挤压和侵入。作者研究了5例巩膜扣固定的眼球摘除术,时间为3至48个月。因为“痛苦的失明”,眼镜被取下了。作者的研究包括组织形态学分析。作者观察到异物肉芽肿反应及腱鞘囊和巩膜广泛纤维化。目前,巩膜屈曲作用的确切机制仍不确定。
{"title":"Pathologic processes associated with the use of scleral buckling in humans","authors":"R. Misra","doi":"10.1109/SBEC.1995.514463","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514463","url":null,"abstract":"Scleral buckling or indentation over a retinal tear or detachment was popularized by Ernst Custodis in 1953. Since then it has become one of the most popular and effective retinal reattachment surgical procedures. Although a few biologic materials such as fascia lata, lyophilized sclera and gelatin are used sometimes as scleral buckles, the most common material for buckles currently used is derivatives of medical grade silicone rubber or MAI. When the scleral buckling material is of foreign origin, the body reacts with acute and chronic inflammation, extrusion, and intrusion. The author has studied five eneucleated globes, with scleral buckles in place for periods of 3 to 48 months. The globes were removed for \"painful blind eyes\". The author's studies consisted of histomorphological analyses. The author observed foreign body granulomatous reaction and extensive fibrosis of Tenon's capsule and the sclera. The precise mechanism by which scleral buckling works remain uncertain at this time.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125424546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The acoustic sweep method for monitoring osteoporosis 超声扫描法监测骨质疏松症
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514491
S. Panteliou, H. Abbasi-Jahromi, A. Dimarogonas
A non-invasive method to measure bone integrity has been developed which has potential for monitoring osteoporosis. It is based on a patented process of obtaining the dynamic characteristics of the bone using dynamic excitation in the range of acoustic frequencies (a sound source). The Modal Damping Factor has been used as an indicator of the tendency of the bone to fracture. Results of numerous animal studies have supported this hypothesis.
一种非侵入性测量骨完整性的方法已被开发出来,具有监测骨质疏松症的潜力。它基于一项专利过程,该过程使用声学频率范围内的动态激励(声源)获得骨骼的动态特性。模态阻尼系数已被用作骨断裂倾向的指标。大量的动物研究结果支持这一假设。
{"title":"The acoustic sweep method for monitoring osteoporosis","authors":"S. Panteliou, H. Abbasi-Jahromi, A. Dimarogonas","doi":"10.1109/SBEC.1995.514491","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514491","url":null,"abstract":"A non-invasive method to measure bone integrity has been developed which has potential for monitoring osteoporosis. It is based on a patented process of obtaining the dynamic characteristics of the bone using dynamic excitation in the range of acoustic frequencies (a sound source). The Modal Damping Factor has been used as an indicator of the tendency of the bone to fracture. Results of numerous animal studies have supported this hypothesis.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117057341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aging characteristics of four hybrid glass ionomers 四种杂化玻璃离子的老化特性
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514439
B. Bennett, A. Puckett, J. Fitchie
Summary form only given. The objective of this study was to evaluate the change in Barcol hardness of five different hybrid glass ionomers (GI) after storage in distilled H/sub 2/O at 37/spl deg/C. The materials were (A) Encapsulated and (B) Handmixed Variglass (Caulk Dentsply, Milford, DE), (C) Vitremer (3M, St. Paul, MN), (D) Fuji II (GC Corp., Tokyo, Japan) and (E) Photacfil (ESPE Premier, Norristown, PA). Barcol hardness measurements were taken on all the samples after twenty-four hours, 1 week and 1 month of aging. Comparison of the initial hardness using ANOVA (p<0.05) revealed no significant differences. However, materials A and B showed a decrease in hardness after 1 week of storage. In contrast, materials C, D and E showed a significant increase (p<0.05) in hardness after storage. Based upon these results, it may be concluded that materials C, D and E continue to react during aging resulting in a harder material. In contrast, the materials A and B do not continue to react but actually become softer due to plasticization by absorbed water. The additional reaction of materials C, D and E is most probably the result of further ionic crosslinking which may be facilitated by water absorption.
只提供摘要形式。本研究的目的是评价5种不同的杂化玻璃离子(GI)在37℃/spl℃的蒸馏H/sub /O中保存后的硬度变化。材料为(A)封装和(B)手工混合varigglass (Caulk Dentsply, Milford, DE), (C) Vitremer (3M, St. Paul, MN), (D) Fuji II (GC Corp, Tokyo, Japan)和(E) Photacfil (ESPE Premier, Norristown, PA)。分别在时效24小时、1周和1个月后对样品进行巴氏硬度测定。采用方差分析比较初始硬度(p<0.05),差异无统计学意义。然而,材料A和材料B在储存1周后硬度下降。C、D、E材料贮藏后硬度显著升高(p<0.05)。根据这些结果,可以得出结论,材料C、D和E在时效过程中继续发生反应,导致材料变硬。相反,材料A和材料B不会继续反应,而是由于吸收的水的塑化而变得更软。材料C、D和E的附加反应很可能是进一步离子交联的结果,而离子交联可以通过吸水来促进。
{"title":"Aging characteristics of four hybrid glass ionomers","authors":"B. Bennett, A. Puckett, J. Fitchie","doi":"10.1109/SBEC.1995.514439","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514439","url":null,"abstract":"Summary form only given. The objective of this study was to evaluate the change in Barcol hardness of five different hybrid glass ionomers (GI) after storage in distilled H/sub 2/O at 37/spl deg/C. The materials were (A) Encapsulated and (B) Handmixed Variglass (Caulk Dentsply, Milford, DE), (C) Vitremer (3M, St. Paul, MN), (D) Fuji II (GC Corp., Tokyo, Japan) and (E) Photacfil (ESPE Premier, Norristown, PA). Barcol hardness measurements were taken on all the samples after twenty-four hours, 1 week and 1 month of aging. Comparison of the initial hardness using ANOVA (p<0.05) revealed no significant differences. However, materials A and B showed a decrease in hardness after 1 week of storage. In contrast, materials C, D and E showed a significant increase (p<0.05) in hardness after storage. Based upon these results, it may be concluded that materials C, D and E continue to react during aging resulting in a harder material. In contrast, the materials A and B do not continue to react but actually become softer due to plasticization by absorbed water. The additional reaction of materials C, D and E is most probably the result of further ionic crosslinking which may be facilitated by water absorption.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129400461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell adhesion strength to bioceramics and morphology 细胞对生物陶瓷的粘附强度及形态
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514501
T. Tateishi, T. Ushida
The aim of this study is to measure adhesion strength of cultured cells to bioceramics such as alumina, and to adapt a mathematical model of defect growth kinetics to the cell adhesion phenomena. Fibroblasts from mouse (L-929) were cultured on alumina plates and fibronectin-coated alumina plates. The adhesion strength was measured by loading adhered cells with centrifugal force vertical to the material's surface. At the same time, we measured adhered areas and morphology of cells on the 2 types of surfaces by using an image analyzing method. The results show that the cells adhered more tightly to fibronectin coated alumina than to alumina. (50% of the cells were peeled off from the fibronectin-coated alumina under the load of 500 G, while 50% of the cells were peeled off from the alumina under the load of 100 G.) The image processed data show that the average of adhered areas of cells to fibronectin coated alumina was 3 times as large as to alumina 6 hours after seeding. The results show influence of fibronectin-receptor bonds on the cell's adhesion strength and the cell's adhesion phenomena. Considering the influence of fibronectin-receptor bonds, a mathematical model of defect growth kinetics was adapted to the cells adhesion phenomena, where we assumed that the rate of condensation of vacancies or the rate of rupture of fibronectin-receptor bonds at the tip of the crack was proportional to the radius of the crack.
本研究的目的是测量培养细胞对生物陶瓷(如氧化铝)的粘附强度,并使缺陷生长动力学的数学模型适应细胞粘附现象。小鼠成纤维细胞(L-929)在氧化铝板和纤维连接蛋白包被的氧化铝板上培养。粘附强度是通过将粘附细胞以离心力垂直加载到材料表面来测量的。同时,我们用图像分析的方法测量了两种表面的粘附面积和细胞形态。结果表明,细胞与纤维连接蛋白包被氧化铝的粘附比与氧化铝的粘附更紧密。(在500 G的负载下,50%的细胞从纤维连接蛋白涂层的氧化铝上脱落,而在100 G的负载下,50%的细胞从氧化铝上脱落。)图像处理数据显示,在播种6小时后,细胞对纤维连接蛋白包被氧化铝的平均粘附面积是对氧化铝的3倍。结果表明,纤维连接蛋白-受体键对细胞的粘附强度和细胞粘附现象有影响。考虑到纤维连接蛋白-受体键的影响,缺陷生长动力学的数学模型适用于细胞粘附现象,其中我们假设在裂纹尖端空位的凝结速率或纤维连接蛋白-受体键的破裂速率与裂纹的半径成正比。
{"title":"Cell adhesion strength to bioceramics and morphology","authors":"T. Tateishi, T. Ushida","doi":"10.1109/SBEC.1995.514501","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514501","url":null,"abstract":"The aim of this study is to measure adhesion strength of cultured cells to bioceramics such as alumina, and to adapt a mathematical model of defect growth kinetics to the cell adhesion phenomena. Fibroblasts from mouse (L-929) were cultured on alumina plates and fibronectin-coated alumina plates. The adhesion strength was measured by loading adhered cells with centrifugal force vertical to the material's surface. At the same time, we measured adhered areas and morphology of cells on the 2 types of surfaces by using an image analyzing method. The results show that the cells adhered more tightly to fibronectin coated alumina than to alumina. (50% of the cells were peeled off from the fibronectin-coated alumina under the load of 500 G, while 50% of the cells were peeled off from the alumina under the load of 100 G.) The image processed data show that the average of adhered areas of cells to fibronectin coated alumina was 3 times as large as to alumina 6 hours after seeding. The results show influence of fibronectin-receptor bonds on the cell's adhesion strength and the cell's adhesion phenomena. Considering the influence of fibronectin-receptor bonds, a mathematical model of defect growth kinetics was adapted to the cells adhesion phenomena, where we assumed that the rate of condensation of vacancies or the rate of rupture of fibronectin-receptor bonds at the tip of the crack was proportional to the radius of the crack.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126280255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficiency of muscular contractions in mouse is different from that in frog 小鼠肌肉收缩的效率与青蛙不同
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514475
C. Yin, R. Woledge
Traditionally, muscle efficiency studies were performed on frog muscles. Muscles of other animal species are assumed to have efficiency values similar to that in frog muscles. This assumption has not been vigorously tested. Our goal was to test this assumption by determining efficiencies of mouse and frog muscles and comparing them. Mouse soleus and frog semitendinosus muscles were isolated and stimulated electrically to produce shortening against external load. The force, muscle length and temperature change associated with these contractions were recorded simultaneously. Efficiency values were worked out from these signals. Our results showed that mouse soleus muscle had a significantly lower efficiency than frog semitendinosus.
传统上,肌肉效率研究是在青蛙肌肉上进行的。其他动物的肌肉被认为具有与青蛙肌肉相似的效率值。这一假设尚未得到有力的检验。我们的目标是通过测定老鼠和青蛙肌肉的效率并进行比较来验证这一假设。分离小鼠比目鱼肌和青蛙半腱肌,电刺激使其在外部负荷下缩短。同时记录与这些收缩相关的力、肌肉长度和温度变化。利用这些信号计算出效率值。我们的研究结果表明,小鼠比目鱼肌的效率明显低于青蛙半腱肌。
{"title":"Efficiency of muscular contractions in mouse is different from that in frog","authors":"C. Yin, R. Woledge","doi":"10.1109/SBEC.1995.514475","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514475","url":null,"abstract":"Traditionally, muscle efficiency studies were performed on frog muscles. Muscles of other animal species are assumed to have efficiency values similar to that in frog muscles. This assumption has not been vigorously tested. Our goal was to test this assumption by determining efficiencies of mouse and frog muscles and comparing them. Mouse soleus and frog semitendinosus muscles were isolated and stimulated electrically to produce shortening against external load. The force, muscle length and temperature change associated with these contractions were recorded simultaneously. Efficiency values were worked out from these signals. Our results showed that mouse soleus muscle had a significantly lower efficiency than frog semitendinosus.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123713620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Model of the behavior of a Kirschner-Ehmer style external fixator clamp Kirschner-Ehmer型外固定钳的行为模型
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514486
G. Pijanowski, J. W. Phillips, M. Swindeman
Several Kirschner-Ehmer style clamps used in external fixation of fractures were loaded in various configurations. The clamp was found to be characterized mechanically as a torsional spring, rather than a rigid connector between a sidebar and a bone pin. Also, the center of rotation is offset from the center of the bolt. Proper modeling of planar unilateral and bilateral fixator frames should be possible by treating the KE-style clamp as a torsional spring with a center of rotation displaced slightly toward the sidebar.
几种用于骨折外固定的克氏钳以不同的配置加载。发现钳的机械特征为扭转弹簧,而不是侧栏和骨钉之间的刚性连接器。此外,旋转中心与螺栓的中心偏移。通过将ke型钳视为旋转中心略微向侧栏偏移的扭转弹簧,可以对平面单侧和双侧固定架框架进行适当的建模。
{"title":"Model of the behavior of a Kirschner-Ehmer style external fixator clamp","authors":"G. Pijanowski, J. W. Phillips, M. Swindeman","doi":"10.1109/SBEC.1995.514486","DOIUrl":"https://doi.org/10.1109/SBEC.1995.514486","url":null,"abstract":"Several Kirschner-Ehmer style clamps used in external fixation of fractures were loaded in various configurations. The clamp was found to be characterized mechanically as a torsional spring, rather than a rigid connector between a sidebar and a bone pin. Also, the center of rotation is offset from the center of the bolt. Proper modeling of planar unilateral and bilateral fixator frames should be possible by treating the KE-style clamp as a torsional spring with a center of rotation displaced slightly toward the sidebar.","PeriodicalId":332563,"journal":{"name":"Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1995-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129854222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1