首页 > 最新文献

Fundamental Research最新文献

英文 中文
The evolving landscape of spatial proteomics technologies in the AI age 人工智能时代空间蛋白质组学技术的发展前景
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2024.11.023
Beiyu Hu , Junjie Zhu , Fangqing Zhao
Although single-cell technologies have provided deep insights into cellular heterogeneity and complexity, they fall short in explaining how cells form tissue structures, a crucial aspect for understanding the principles of complex tissues. Recently, spatial transcriptomics has begun to fill this gap, allowing in situ studies of tissues at cellular and subcellular resolution. However, these genomic-level methods primarily provide indirect measurements of cellular states, as most biological processes are controlled by proteins. Therefore, spatial proteomics has the potential to revolutionize our understanding of biological processes, with significant implications for both basic cell biology and clinical applications. In this review, we provide an overview of the recent technical achievements and remaining challenges in spatial proteomics. Specifically, we categorize the techniques into three main types: antibody-based, LC-MS/MS-based, and imaging mass spectrometry-based. We describe each method in detail and discuss its strengths and weaknesses. We also discuss the emerging opportunities of artificial intelligence for spatial proteomics. Finally, we review key issues and suggest future directions for the advancement of spatial proteomics.
尽管单细胞技术提供了对细胞异质性和复杂性的深刻见解,但它们在解释细胞如何形成组织结构方面存在不足,而这是理解复杂组织原理的关键方面。最近,空间转录组学已经开始填补这一空白,允许在细胞和亚细胞分辨率的组织原位研究。然而,这些基因组水平的方法主要提供细胞状态的间接测量,因为大多数生物过程是由蛋白质控制的。因此,空间蛋白质组学有可能彻底改变我们对生物过程的理解,对基础细胞生物学和临床应用都具有重要意义。本文综述了空间蛋白质组学研究的最新进展和面临的挑战。具体来说,我们将这些技术分为三种主要类型:基于抗体的、基于LC-MS/ ms的和基于成像质谱的。我们详细描述了每种方法,并讨论了其优缺点。我们还讨论了人工智能在空间蛋白质组学中的新机遇。最后,对空间蛋白质组学研究中存在的关键问题进行了综述,并对未来的研究方向进行了展望。
{"title":"The evolving landscape of spatial proteomics technologies in the AI age","authors":"Beiyu Hu ,&nbsp;Junjie Zhu ,&nbsp;Fangqing Zhao","doi":"10.1016/j.fmre.2024.11.023","DOIUrl":"10.1016/j.fmre.2024.11.023","url":null,"abstract":"<div><div>Although single-cell technologies have provided deep insights into cellular heterogeneity and complexity, they fall short in explaining how cells form tissue structures, a crucial aspect for understanding the principles of complex tissues. Recently, spatial transcriptomics has begun to fill this gap, allowing in situ studies of tissues at cellular and subcellular resolution. However, these genomic-level methods primarily provide indirect measurements of cellular states, as most biological processes are controlled by proteins. Therefore, spatial proteomics has the potential to revolutionize our understanding of biological processes, with significant implications for both basic cell biology and clinical applications. In this review, we provide an overview of the recent technical achievements and remaining challenges in spatial proteomics. Specifically, we categorize the techniques into three main types: antibody-based, LC-MS/MS-based, and imaging mass spectrometry-based. We describe each method in detail and discuss its strengths and weaknesses. We also discuss the emerging opportunities of artificial intelligence for spatial proteomics. Finally, we review key issues and suggest future directions for the advancement of spatial proteomics.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 28-39"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding intrinsically disordered regions in biomolecular condensates 解码生物分子凝聚体中的内在无序区域
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2025.01.013
Minglei Shi , Zhaoxu Wu , Yi Zhang , Tingting Li
Biomolecular condensates comprise a diverse array of molecular entities, with intrinsically disordered regions (IDRs) receiving mounting attention due to their pivotal roles. In recent years, significant progress has been made in understanding the linear and conformational molecular grammar of IDRs in biomolecular condensates. This review will focus on the advances in studying IDR conformational ensembles and their relationship to function, with a particular emphasis on molecular dynamics (MD) simulations and the emerging synergy between MD and machine learning (ML) methods. Nevertheless, the inherent flexibility and dynamic nature of IDRs continue to present substantial challenges for conformation analysis. The integration of advanced experimental techniques, computational methods, and evolutionary analysis promises to unveil the conformational mysteries and therapeutic potential of IDRs in condensates.
生物分子凝聚物由多种分子实体组成,内在无序区(IDRs)因其关键作用而受到越来越多的关注。近年来,对生物分子凝聚物中idr的线性和构象分子语法的研究取得了重大进展。本文将重点介绍IDR构象集成及其与功能关系的研究进展,特别强调分子动力学(MD)模拟以及MD与机器学习(ML)方法之间的新兴协同作用。然而,idr固有的灵活性和动态性质继续对构象分析提出重大挑战。将先进的实验技术、计算方法和进化分析相结合,有望揭开凝析油中idr的构象之谜和治疗潜力。
{"title":"Decoding intrinsically disordered regions in biomolecular condensates","authors":"Minglei Shi ,&nbsp;Zhaoxu Wu ,&nbsp;Yi Zhang ,&nbsp;Tingting Li","doi":"10.1016/j.fmre.2025.01.013","DOIUrl":"10.1016/j.fmre.2025.01.013","url":null,"abstract":"<div><div>Biomolecular condensates comprise a diverse array of molecular entities, with intrinsically disordered regions (IDRs) receiving mounting attention due to their pivotal roles. In recent years, significant progress has been made in understanding the linear and conformational molecular grammar of IDRs in biomolecular condensates. This review will focus on the advances in studying IDR conformational ensembles and their relationship to function, with a particular emphasis on molecular dynamics (MD) simulations and the emerging synergy between MD and machine learning (ML) methods. Nevertheless, the inherent flexibility and dynamic nature of IDRs continue to present substantial challenges for conformation analysis. The integration of advanced experimental techniques, computational methods, and evolutionary analysis promises to unveil the conformational mysteries and therapeutic potential of IDRs in condensates.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 53-61"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contrasting patterns for bacteria and archaea in response to salt stress across alpine wetlands of the Tibetan Plateau 青藏高原高寒湿地的细菌和古细菌对盐胁迫的反应模式截然不同
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2024.02.010
Xu Liu , Manuel Delgado-Baquerizo , Teng Yang , Gui-Feng Gao , Yu Shi , Haiyan Chu
Understanding microbial responses to environmental stress is crucial for comprehending their distribution and supporting conservation efforts. Yet, comprehensive evaluations of these responses across diverse microbial taxa within the framework of classical ecological theories are scarce. This gap limits our ability to predict the impact of environmental changes on the diversity and functions of soil microbes in natural settings. In this study, we conducted a field survey across twenty alpine wetlands on the Tibetan Plateau. Employing amplicon sequencing with network theories, we investigated the biodiversity and coexistence of bacteria and archaea under a wide range of natural salinity conditions. Our results demonstrated a linear decrease in bacterial diversity with increased salinity, while archaeal diversity showed a non-linear pattern, initially declining and then rising, reflecting varied adaptation strategies to salt stress. Network analysis revealed a heightened complexity in positive associations among bacteria under salt stress. In contrast, archaea exhibited a decrease in both positive and negative associations, with the community succession to halophiles. These results imply that bacteria may counteract stress through enhanced facilitation, whereas archaea predominantly rely on stress-tolerant taxa. Additionally, structural equation modeling confirmed our hypothesis regarding the ecological response strategies of bacteria and archaea to salinity stress, showing that the variation in bacterial diversity is mainly explained by the complexity of positive associations, whereas archaeal diversity directly correlates with salinity levels. Overall, this study offers novel insights into the ecological strategies of prokaryotes under salinity stress and enriches our understanding of the processes maintaining microbial diversity in stressful conditions.
了解微生物对环境胁迫的反应对于了解其分布和支持保护工作至关重要。然而,在经典生态学理论的框架内,对不同微生物类群的这些反应进行综合评估是稀缺的。这一差距限制了我们预测自然环境下环境变化对土壤微生物多样性和功能的影响的能力。本研究对青藏高原20个高寒湿地进行了野外调查。利用扩增子测序和网络理论,我们研究了在广泛的自然盐度条件下细菌和古细菌的生物多样性和共存。结果表明,随着盐度的增加,细菌多样性呈线性下降,而古细菌多样性呈先下降后上升的非线性模式,反映了对盐胁迫的不同适应策略。网络分析显示,盐胁迫下细菌间正相关关系的复杂性增加。相比之下,古菌表现出正相关和负相关的减少,随着群落演替到嗜盐菌。这些结果表明,细菌可能通过增强的促进作用来抵消压力,而古细菌主要依赖于耐压力的分类群。此外,结构方程模型证实了我们关于细菌和古菌对盐度胁迫的生态响应策略的假设,表明细菌多样性的变化主要由正相关的复杂性来解释,而古菌多样性与盐度水平直接相关。总的来说,这项研究为原核生物在盐度胁迫下的生态策略提供了新的见解,并丰富了我们对胁迫条件下维持微生物多样性的过程的理解。
{"title":"Contrasting patterns for bacteria and archaea in response to salt stress across alpine wetlands of the Tibetan Plateau","authors":"Xu Liu ,&nbsp;Manuel Delgado-Baquerizo ,&nbsp;Teng Yang ,&nbsp;Gui-Feng Gao ,&nbsp;Yu Shi ,&nbsp;Haiyan Chu","doi":"10.1016/j.fmre.2024.02.010","DOIUrl":"10.1016/j.fmre.2024.02.010","url":null,"abstract":"<div><div>Understanding microbial responses to environmental stress is crucial for comprehending their distribution and supporting conservation efforts. Yet, comprehensive evaluations of these responses across diverse microbial taxa within the framework of classical ecological theories are scarce. This gap limits our ability to predict the impact of environmental changes on the diversity and functions of soil microbes in natural settings. In this study, we conducted a field survey across twenty alpine wetlands on the Tibetan Plateau. Employing amplicon sequencing with network theories, we investigated the biodiversity and coexistence of bacteria and archaea under a wide range of natural salinity conditions. Our results demonstrated a linear decrease in bacterial diversity with increased salinity, while archaeal diversity showed a non-linear pattern, initially declining and then rising, reflecting varied adaptation strategies to salt stress. Network analysis revealed a heightened complexity in positive associations among bacteria under salt stress. In contrast, archaea exhibited a decrease in both positive and negative associations, with the community succession to halophiles. These results imply that bacteria may counteract stress through enhanced facilitation, whereas archaea predominantly rely on stress-tolerant taxa. Additionally, structural equation modeling confirmed our hypothesis regarding the ecological response strategies of bacteria and archaea to salinity stress, showing that the variation in bacterial diversity is mainly explained by the complexity of positive associations, whereas archaeal diversity directly correlates with salinity levels. Overall, this study offers novel insights into the ecological strategies of prokaryotes under salinity stress and enriches our understanding of the processes maintaining microbial diversity in stressful conditions.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 313-323"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140277851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing non-Newtonian gravity constraint using a levitated pendulum in vacuum 利用真空中的悬浮摆加强非牛顿重力约束
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2023.12.008
Fang Xiong , Leilei Guo , Pu Huang , Xiaowen Gao , Zhiming Chen , Xunmin Zhu , Tong Wu , Huizhu Hu
The detection of non-Newtonian gravity is crucial for fundamental physics research and our understanding of dark energy. However, conducting an experiment that provides explicit evidence of its existence remains an endeavour. We propose an experiment utilizing a diamagnetically levitated pendulum in vacuum to detect non-Newtonian gravity on a micrometer scale. The pendulum configuration effectively helps to shield electromagnetic force fluctuations in the vacuum levitation system. The structural parameters of the pendulum are intentionally optimized to enhance the constraint on the non-Newtonian gravity strength α. The designed pendulum can be stably levitated in the diamagnetic trap thanks to its passive levitation mechanism. By conducting resonance force measurements at room temperature for a duration of 104 s, we anticipate a significant improvement in the constraint on the non-Newtonian gravity strength (α28) within the force range of λ=7.6 µm. This represents an enhancement of over three orders of magnitude compared to the current limit. This study presents a promising tool for investigating short-range forces and exploring frontier physics in tabletop laboratory.
探测非牛顿引力对于基础物理研究和我们对暗能量的理解至关重要。然而,进行一项实验来提供它存在的明确证据仍然是一项努力。我们提出了一个实验利用反磁悬浮摆在真空中检测非牛顿重力在微米尺度。摆摆结构有效地屏蔽了真空悬浮系统中的电磁力波动。为了增强对非牛顿重力强度α的约束,特意对摆的结构参数进行了优化。利用被动悬浮机制,设计的摆锤可以在抗磁阱中稳定悬浮。通过在室温下进行持续104 s的共振力测量,我们预计在λ=7.6µm的力范围内,对非牛顿重力强度(α≥28)的约束有显著改善。这比目前的限制提高了三个数量级以上。该研究为桌面实验室研究近程力和探索前沿物理提供了一种很有前途的工具。
{"title":"Enhancing non-Newtonian gravity constraint using a levitated pendulum in vacuum","authors":"Fang Xiong ,&nbsp;Leilei Guo ,&nbsp;Pu Huang ,&nbsp;Xiaowen Gao ,&nbsp;Zhiming Chen ,&nbsp;Xunmin Zhu ,&nbsp;Tong Wu ,&nbsp;Huizhu Hu","doi":"10.1016/j.fmre.2023.12.008","DOIUrl":"10.1016/j.fmre.2023.12.008","url":null,"abstract":"<div><div>The detection of non-Newtonian gravity is crucial for fundamental physics research and our understanding of dark energy. However, conducting an experiment that provides explicit evidence of its existence remains an endeavour. We propose an experiment utilizing a diamagnetically levitated pendulum in vacuum to detect non-Newtonian gravity on a micrometer scale. The pendulum configuration effectively helps to shield electromagnetic force fluctuations in the vacuum levitation system. The structural parameters of the pendulum are intentionally optimized to enhance the constraint on the non-Newtonian gravity strength <span><math><mi>α</mi></math></span>. The designed pendulum can be stably levitated in the diamagnetic trap thanks to its passive levitation mechanism. By conducting resonance force measurements at room temperature for a duration of <span><math><msup><mn>10</mn><mn>4</mn></msup></math></span> s, we anticipate a significant improvement in the constraint on the non-Newtonian gravity strength (<span><math><mrow><mi>α</mi><mo>≥</mo><mn>28</mn></mrow></math></span>) within the force range of <span><math><mrow><mi>λ</mi><mo>=</mo><mn>7.6</mn></mrow></math></span> µm. This represents an enhancement of over three orders of magnitude compared to the current limit. This study presents a promising tool for investigating short-range forces and exploring frontier physics in tabletop laboratory.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 141-148"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139637731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concept, development and applications of DNA computation DNA计算的概念、发展和应用
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2023.06.015
Mingzhi Zhang , Da Han
As traditional silicon-based chips approach their theoretical limits on computing power, DNA-based computation presents a promising alternative with potential advantages such as reduced size, high storage density, low consumption, long-term stability and the ability to perform in memory-computing. This review provides a summarized overview of DNA computation, covering its history, development and applications. In addition, we also highlight the possible directions to address the challenges that stand in the way of realizing the full potentials of this technology.
当传统的硅基芯片接近计算能力的理论极限时,基于dna的计算呈现出一种很有前途的替代方案,具有体积小、存储密度高、功耗低、长期稳定以及能够执行内存计算等潜在优势。本文综述了DNA计算的历史、发展和应用。此外,我们还强调了解决阻碍实现这项技术全部潜力的挑战的可能方向。
{"title":"Concept, development and applications of DNA computation","authors":"Mingzhi Zhang ,&nbsp;Da Han","doi":"10.1016/j.fmre.2023.06.015","DOIUrl":"10.1016/j.fmre.2023.06.015","url":null,"abstract":"<div><div>As traditional silicon-based chips approach their theoretical limits on computing power, DNA-based computation presents a promising alternative with potential advantages such as reduced size, high storage density, low consumption, long-term stability and the ability to perform in memory-computing. This review provides a summarized overview of DNA computation, covering its history, development and applications. In addition, we also highlight the possible directions to address the challenges that stand in the way of realizing the full potentials of this technology.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 178-183"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135347832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preformer MOT: A transformer-based approach for multi-object tracking with global trajectory prediction Preformer MOT:一种基于变压器的全局轨迹预测多目标跟踪方法
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2024.06.015
Yueying Wang , Yuhao Qing , Kaer Huang , Chuangyin Dang , Zhengtian Wu
Multi-Object Tracking (MOT) is designed to accurately ascertain the positions and trajectories of moving objects within a video sequence. While prevalent methodologies primarily link detected objects across successive frames by leveraging appearance and motion attributes, some approaches incorporate implicit global correlations from multiple antecedent frames to delineate target trajectories. Nonetheless, the capability to predict trajectories over multiple future frames remains insufficiently explored, leading to a significant underutilization of pertinent information in MOT. To address this gap, we introduce a transformer-based methodology, termed Preformer MOT, which enhances the precision of nonlinear trajectory predictions in dynamic settings. This enhancement is achieved through an innovative combination of a novel motion estimation technique-trajectory prediction-and Kalman filtering. Our method not only utilizes historical trajectory data but also anticipates the future positions of the target objects up to n subsequent steps, thereby furnishing a comprehensive prediction of trajectories with extensive temporal correlations. Specifically, we develop a straightforward self-supervised trajectory prediction model that estimates the future positions of a target object based on previously observed positional data. During the correlation phase, if a trajectory disruption occurs due to overlapping, occlusion, or nonlinear movements of the detected objects, Preformer MOT is capable of making early predictions using data from multiple forthcoming frames to reestablish trajectory continuity. Empirical evaluations on pedestrian datasets such as DanceTrack and MOT17 demonstrate that our approach surpasses other contemporary state-of-the-art methods. Furthermore, Preformer MOT exhibits exceptional performance in complex marine environments, underscoring its adaptability and efficacy.
多目标跟踪(MOT)的目的是准确地确定视频序列中运动物体的位置和轨迹。虽然流行的方法主要是通过利用外观和运动属性将检测到的对象跨连续帧连接起来,但一些方法结合了来自多个前帧的隐式全局相关性来描绘目标轨迹。尽管如此,预测多个未来框架的轨迹的能力仍然没有得到充分的探索,导致MOT中相关信息的利用严重不足。为了解决这一差距,我们引入了一种基于变压器的方法,称为Preformer MOT,它提高了动态设置下非线性轨迹预测的精度。这种增强是通过一种新的运动估计技术-轨迹预测-和卡尔曼滤波的创新组合来实现的。我们的方法不仅利用了历史轨迹数据,而且还预测了目标物体在后续n步中的未来位置,从而提供了具有广泛时间相关性的轨迹的全面预测。具体来说,我们开发了一个直接的自监督轨迹预测模型,该模型基于先前观察到的位置数据估计目标物体的未来位置。在相关阶段,如果由于检测到的物体的重叠、遮挡或非线性运动而导致轨迹中断,Preformer MOT能够使用来自多个即将到来的帧的数据进行早期预测,以重建轨迹连续性。对DanceTrack和MOT17等行人数据集的实证评估表明,我们的方法优于其他当代最先进的方法。此外,Preformer MOT在复杂的海洋环境中表现出优异的性能,突出了其适应性和有效性。
{"title":"Preformer MOT: A transformer-based approach for multi-object tracking with global trajectory prediction","authors":"Yueying Wang ,&nbsp;Yuhao Qing ,&nbsp;Kaer Huang ,&nbsp;Chuangyin Dang ,&nbsp;Zhengtian Wu","doi":"10.1016/j.fmre.2024.06.015","DOIUrl":"10.1016/j.fmre.2024.06.015","url":null,"abstract":"<div><div>Multi-Object Tracking (MOT) is designed to accurately ascertain the positions and trajectories of moving objects within a video sequence. While prevalent methodologies primarily link detected objects across successive frames by leveraging appearance and motion attributes, some approaches incorporate implicit global correlations from multiple antecedent frames to delineate target trajectories. Nonetheless, the capability to predict trajectories over multiple future frames remains insufficiently explored, leading to a significant underutilization of pertinent information in MOT. To address this gap, we introduce a transformer-based methodology, termed Preformer MOT, which enhances the precision of nonlinear trajectory predictions in dynamic settings. This enhancement is achieved through an innovative combination of a novel motion estimation technique-trajectory prediction-and Kalman filtering. Our method not only utilizes historical trajectory data but also anticipates the future positions of the target objects up to n subsequent steps, thereby furnishing a comprehensive prediction of trajectories with extensive temporal correlations. Specifically, we develop a straightforward self-supervised trajectory prediction model that estimates the future positions of a target object based on previously observed positional data. During the correlation phase, if a trajectory disruption occurs due to overlapping, occlusion, or nonlinear movements of the detected objects, Preformer MOT is capable of making early predictions using data from multiple forthcoming frames to reestablish trajectory continuity. Empirical evaluations on pedestrian datasets such as DanceTrack and MOT17 demonstrate that our approach surpasses other contemporary state-of-the-art methods. Furthermore, Preformer MOT exhibits exceptional performance in complex marine environments, underscoring its adaptability and efficacy.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 423-431"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rendering compact formation and trajectory tracking for cyber unmanned ground vehicles 网络无人地面车辆的紧凑编队与轨迹跟踪绘制
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2023.08.018
Xiaomin Zhao , Zhengrong Cui , Chee-Meng Chew , Fangfang Dong
This paper considers the cooperative control problem for the unmanned ground vehicle swarm system with cyber interference. Each vehicle in the system is intelligent and connected with each other via networks. The cyber security issue is inevitable and vital in the control design for the swarm system. Taking account of the cyber interference and system uncertainty, we explore the cooperative control for the unmanned ground vehicle swarm system. In order to describe the behaviors of mutual attraction, repulsion and overall trajectory tracking in a mathematical manner, we abstract the integrated potential function, thereby the kinematic model. Treating the mathematical model as the system constraint and decomposing the system uncertainty, we propose a class of cooperative adaptive robust controls to assure that all the unmanned ground vehicles follow the constraint to move. Four major system performances are achieved: (i) global stability (i.e., uniform boundedness and uniform ultimate boundedness), (ii) compact formation, (iii) cooperative hunting, (iv) trajectory tracking.
研究了具有网络干扰的地面无人车辆群系统的协同控制问题。系统中的每辆车都是智能的,并通过网络相互连接。在群系统的控制设计中,网络安全问题是不可避免的,也是至关重要的。考虑网络干扰和系统不确定性,探讨了无人地面车辆群系统的协同控制问题。为了用数学的方式描述相互吸引、排斥和整体轨迹跟踪的行为,我们抽象了积分势函数,从而得到了运动学模型。将数学模型视为系统约束,对系统不确定性进行分解,提出了一类协同自适应鲁棒控制,以保证所有地面无人车辆都遵循约束进行运动。实现了四种主要的系统性能:(i)全局稳定性(即均匀有界性和均匀最终有界性),(ii)紧凑队形,(iii)合作狩猎,(iv)轨迹跟踪。
{"title":"Rendering compact formation and trajectory tracking for cyber unmanned ground vehicles","authors":"Xiaomin Zhao ,&nbsp;Zhengrong Cui ,&nbsp;Chee-Meng Chew ,&nbsp;Fangfang Dong","doi":"10.1016/j.fmre.2023.08.018","DOIUrl":"10.1016/j.fmre.2023.08.018","url":null,"abstract":"<div><div>This paper considers the cooperative control problem for the unmanned ground vehicle swarm system with cyber interference. Each vehicle in the system is intelligent and connected with each other via networks. The cyber security issue is inevitable and vital in the control design for the swarm system. Taking account of the cyber interference and system uncertainty, we explore the cooperative control for the unmanned ground vehicle swarm system. In order to describe the behaviors of mutual attraction, repulsion and overall trajectory tracking in a mathematical manner, we abstract the integrated potential function, thereby the kinematic model. Treating the mathematical model as the system constraint and decomposing the system uncertainty, we propose a class of cooperative adaptive robust controls to assure that all the unmanned ground vehicles follow the constraint to move. Four major system performances are achieved: (i) global stability (i.e., uniform boundedness and uniform ultimate boundedness), (ii) compact formation, (iii) cooperative hunting, (iv) trajectory tracking.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 369-379"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioavailability factor for improved drinking water contaminant exposure risk assessment accuracy 提高饮用水污染物暴露风险评估准确性的生物利用度因子
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2024.10.010
Yayun Zhang , Shengkun Dong , Di Zhang , Michael J. Plewa , Wenhai Chu
Despite being low in concentration, the presence of broad-spectrum chemical constituents in drinking water is a fact of modern life. The current drinking water chemical risk assessment practice predominantly relies on drinking exposure and chemical toxicity data, providing a valuable tool for regulation. However, only a fraction of chemicals is retained for a considerable duration within the human body, as the remainder are excreted or metabolized. This limits the efficacy of risk assessment when exclusively relying on water contaminants ingestion dose and toxicity potencies. We propose large scale incorporation of a bioavailability factor, F, into the calculation of chemical-mediated human health risk assessment for drinking water. Specifically, F values account for the ratio of one compound in human circulation and excretion and are multivariable specific, such as exposure route specific, and gender specific. Utilizing disinfection by-products (DBPs), an important group of chemicals commonly found in drinking water as an example, we provided detailed explanations of F values. Through incorporation of the F values, the accuracy of drinking water human health risk assessment may be improved as the biological retention ratio is accommodated, providing leniency on chemicals that less interact with the human body during internal retention. This approach has clear implications for the subsequent control measures and national drinking water standards updates for emerging pollutants.
尽管浓度很低,但饮用水中广谱化学成分的存在是现代生活的一个事实。目前的饮用水化学品风险评估主要依赖于饮用水暴露和化学品毒性数据,为监管提供了有价值的工具。然而,只有一小部分化学物质在人体内保留相当长的时间,其余的都被排泄或代谢掉了。当仅仅依靠水污染物的摄入剂量和毒性时,这限制了风险评估的有效性。我们建议将生物利用度因子F大规模纳入化学物质介导的饮用水人类健康风险评估的计算中。具体来说,F值反映了一种化合物在人体循环和排泄中的比例,并且具有多变量特异性,例如暴露途径特异性和性别特异性。以饮用水中常见的一组重要化学物质消毒副产物(DBPs)为例,我们提供了F值的详细解释。通过纳入F值,可以提高饮用水人体健康风险评估的准确性,因为可以调节生物滞留比,对在内部滞留期间与人体相互作用较小的化学物质给予宽大处理。这种方法对后续的控制措施和国家饮用水标准的新出现污染物的更新具有明显的影响。
{"title":"Bioavailability factor for improved drinking water contaminant exposure risk assessment accuracy","authors":"Yayun Zhang ,&nbsp;Shengkun Dong ,&nbsp;Di Zhang ,&nbsp;Michael J. Plewa ,&nbsp;Wenhai Chu","doi":"10.1016/j.fmre.2024.10.010","DOIUrl":"10.1016/j.fmre.2024.10.010","url":null,"abstract":"<div><div>Despite being low in concentration, the presence of broad-spectrum chemical constituents in drinking water is a fact of modern life. The current drinking water chemical risk assessment practice predominantly relies on drinking exposure and chemical toxicity data, providing a valuable tool for regulation. However, only a fraction of chemicals is retained for a considerable duration within the human body, as the remainder are excreted or metabolized. This limits the efficacy of risk assessment when exclusively relying on water contaminants ingestion dose and toxicity potencies. We propose large scale incorporation of a bioavailability factor, <em>F</em>, into the calculation of chemical-mediated human health risk assessment for drinking water. Specifically, <em>F</em> values account for the ratio of one compound in human circulation and excretion and are multivariable specific, such as exposure route specific, and gender specific. Utilizing disinfection by-products (DBPs), an important group of chemicals commonly found in drinking water as an example, we provided detailed explanations of <em>F</em> values. Through incorporation of the <em>F</em> values, the accuracy of drinking water human health risk assessment may be improved as the biological retention ratio is accommodated, providing leniency on chemicals that less interact with the human body during internal retention. This approach has clear implications for the subsequent control measures and national drinking water standards updates for emerging pollutants.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 380-382"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the economically sustainable solutions for clean heating in rural Northern China 探索中国北方农村清洁供暖的经济可持续解决方案
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2024.11.020
Feng Wang , Yuzhu Shang , Pengfei Zhang , Wei Zhang , Jiashuo Li
China's Rural Clean Heating Policy (RCHP) is confronted with affordability issues in terms of the increasing household heating costs against the background of subsidies phase out, calling for economically feasible strategies to alleviate the heating burden. By compiling a high-resolution township-level RCHP retrofitting dataset, here we comprehensively assessed the rural residential heating burdens, with or without operational subsidies, and further explored the economically viable clean heating strategies in Northern China. We show that eliminating subsidies would significantly increase rural residential heating expenditure by 36.2% (an average of 523.3 CNY per household), and low-income rural residents in Shandong and Shanxi would bear the most significant increase in heating burdens. The incremental heating costs can be partly offset (18.7%) by RCHP's carbon reduction credits in the context of the Chinese Certified Emission Reduction. Rural rooftop photovoltaics show significant potential in increasing household revenue, particularly in Hebei, Shanxi, and Beijing, where they can compensate for an average of 32.2–64.5% of the increased heating costs. The implementation of tailored subsidy phase-out strategies, coupled with the promotion of distributed PV projects, could enhance the sustainability of clean heating in China.
在补贴逐步取消的背景下,中国农村清洁供暖政策面临着家庭供暖成本不断上升的可负担性问题,需要寻找经济可行的策略来减轻供暖负担。通过编制高分辨率乡镇级RCHP改造数据集,综合评估了有或没有运营补贴的农村居民供暖负担,并进一步探索了经济上可行的中国北方清洁供暖策略。研究表明,取消补贴将使农村居民供暖支出显著增加36.2%(平均每户523.3元),其中山东和山西低收入农村居民的供暖负担增加幅度最大。在中国认证减排的背景下,RCHP的碳减排额度可以部分抵消增加的供暖成本(18.7%)。农村屋顶光伏发电在增加家庭收入方面显示出巨大的潜力,特别是在河北、山西和北京,它们平均可以弥补增加的供暖成本的32.2-64.5%。实施有针对性的补贴逐步取消战略,再加上推广分布式光伏项目,可以增强中国清洁供暖的可持续性。
{"title":"Exploring the economically sustainable solutions for clean heating in rural Northern China","authors":"Feng Wang ,&nbsp;Yuzhu Shang ,&nbsp;Pengfei Zhang ,&nbsp;Wei Zhang ,&nbsp;Jiashuo Li","doi":"10.1016/j.fmre.2024.11.020","DOIUrl":"10.1016/j.fmre.2024.11.020","url":null,"abstract":"<div><div>China's Rural Clean Heating Policy (RCHP) is confronted with affordability issues in terms of the increasing household heating costs against the background of subsidies phase out, calling for economically feasible strategies to alleviate the heating burden. By compiling a high-resolution township-level RCHP retrofitting dataset, here we comprehensively assessed the rural residential heating burdens, with or without operational subsidies, and further explored the economically viable clean heating strategies in Northern China. We show that eliminating subsidies would significantly increase rural residential heating expenditure by 36.2% (an average of 523.3 CNY per household), and low-income rural residents in Shandong and Shanxi would bear the most significant increase in heating burdens. The incremental heating costs can be partly offset (18.7%) by RCHP's carbon reduction credits in the context of the Chinese Certified Emission Reduction. Rural rooftop photovoltaics show significant potential in increasing household revenue, particularly in Hebei, Shanxi, and Beijing, where they can compensate for an average of 32.2–64.5% of the increased heating costs. The implementation of tailored subsidy phase-out strategies, coupled with the promotion of distributed PV projects, could enhance the sustainability of clean heating in China.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 455-464"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revegetation re-carbonizes soil: Patterns, mechanisms, and challenges 植被恢复使土壤再碳化:模式、机制和挑战
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2026-01-01 DOI: 10.1016/j.fmre.2024.06.004
Qingyin Zhang , Yaxian Hu , Mingan Shao , Xiaoxu Jia , Xiaorong Wei
Revegetation has been widely implemented throughout the world for controlling soil loss, conserving biodiversity, increasing ecosystem productivity, mitigating climate change, and contributing to soil carbon (C) sequestration. However, systematic knowledge is still lacking regarding the variations, mechanisms, and challenges in soil C sequestration after revegetation despite its crucial role in resolving the ongoing C sink/source debate and achieving the C neutrality targets. In this review, we summarize the spatiotemporal patterns and drivers of soil organic carbon (SOC) sequestration in restored ecosystems based on existing studies at multiple spatial and temporal scales and the mechanisms associated with C stabilization in soils after revegetation, and suggest future research into soil C in restored ecosystems. Revegetation, i.e. grassland restoration or afforestation/reforestations, significantly increases the SOC sequestration by 21.4% with rapid SOC accumulation in the initial few years (generally within 30 years), followed by a relatively stable stage. We also clarified the three key mechanisms (including physical protection within soil aggregates, chemical protection by interacting with organo-mineral associations, and inherent biological recalcitrance protection) associated with SOC stabilization in soils after revegetation. Revegetation re-carbonizes soil by increasing new inputs of C and decreasing the ratio of soil C outputs to new inputs of C (i.e., increasing the decomposition of SOC and reducing erosional SOC loss), both of which promote SOC sequestration. Based on the key issues identified in this review, future research should focus on the fate of C sequestrated in soils after revegetation, and feedback to environmental changes and human activities in order to achieve C neutrality by around 2050.
在控制土壤流失、保护生物多样性、提高生态系统生产力、减缓气候变化和促进土壤碳(C)固存方面,世界各地都在广泛实施植被恢复。然而,尽管土壤碳在解决碳汇/源争论和实现碳中和目标中发挥着至关重要的作用,但对植被恢复后土壤碳封存的变化、机制和挑战仍缺乏系统的认识。本文在多时空尺度研究的基础上,总结了恢复生态系统土壤有机碳(SOC)固存的时空格局和驱动因素,以及植被恢复后土壤碳稳定的机制,并对恢复生态系统土壤碳的未来研究进行了展望。植被恢复(即草地恢复或造林/再造林)显著增加了21.4%的有机碳固存,并且在最初几年(一般在30年内)快速积累,随后是一个相对稳定的阶段。我们还明确了恢复后土壤有机碳稳定的三个关键机制(包括土壤团聚体内部的物理保护、与有机-矿物关联相互作用的化学保护和内在的生物抗性保护)。植被恢复通过增加碳的新输入量和降低土壤碳输出量与碳新输入量的比值(即增加有机碳的分解和减少侵蚀性有机碳损失)来实现土壤再碳化,这两者都促进了有机碳的固存。基于本文提出的关键问题,未来的研究重点应放在植被恢复后土壤中固存的碳的命运,以及对环境变化和人类活动的反馈,以期在2050年左右实现碳中和。
{"title":"Revegetation re-carbonizes soil: Patterns, mechanisms, and challenges","authors":"Qingyin Zhang ,&nbsp;Yaxian Hu ,&nbsp;Mingan Shao ,&nbsp;Xiaoxu Jia ,&nbsp;Xiaorong Wei","doi":"10.1016/j.fmre.2024.06.004","DOIUrl":"10.1016/j.fmre.2024.06.004","url":null,"abstract":"<div><div>Revegetation has been widely implemented throughout the world for controlling soil loss, conserving biodiversity, increasing ecosystem productivity, mitigating climate change, and contributing to soil carbon (C) sequestration. However, systematic knowledge is still lacking regarding the variations, mechanisms, and challenges in soil C sequestration after revegetation despite its crucial role in resolving the ongoing C sink/source debate and achieving the C neutrality targets. In this review, we summarize the spatiotemporal patterns and drivers of soil organic carbon (SOC) sequestration in restored ecosystems based on existing studies at multiple spatial and temporal scales and the mechanisms associated with C stabilization in soils after revegetation, and suggest future research into soil C in restored ecosystems. Revegetation, i.e. grassland restoration or afforestation/reforestations, significantly increases the SOC sequestration by 21.4% with rapid SOC accumulation in the initial few years (generally within 30 years), followed by a relatively stable stage. We also clarified the three key mechanisms (including physical protection within soil aggregates, chemical protection by interacting with organo-mineral associations, and inherent biological recalcitrance protection) associated with SOC stabilization in soils after revegetation. Revegetation re-carbonizes soil by increasing new inputs of C and decreasing the ratio of soil C outputs to new inputs of C (i.e., increasing the decomposition of SOC and reducing erosional SOC loss), both of which promote SOC sequestration. Based on the key issues identified in this review, future research should focus on the fate of C sequestrated in soils after revegetation, and feedback to environmental changes and human activities in order to achieve C neutrality by around 2050.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"6 1","pages":"Pages 290-300"},"PeriodicalIF":6.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Fundamental Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1