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Challenges of heat stress on intestinal health in pig husbandry 热应激对猪肠道健康的影响
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2025.06.006
Xiaolan Fan , Xue Tian , Mingzhou Li
Global warming has intensified the threat of heat stress in pig husbandry, with the intestine emerging as a primary target of heat-induced injury. This perspective reviews recent advances in our understanding of the complex effects of heat stress on porcine intestinal health. We highlight current intervention strategies implemented in pig farming to enhance resilience against heat stress and mitigate associated intestinal damage. These strategies offer promising avenues to preserve pig health and improve productivity under rising environmental temperatures.
全球变暖加剧了养猪业热应激的威胁,肠道成为热致损伤的主要目标。这一观点回顾了我们对热应激对猪肠道健康的复杂影响的理解的最新进展。我们强调了目前在养猪业中实施的干预策略,以增强对热应激的恢复能力并减轻相关的肠道损伤。这些策略为在不断上升的环境温度下保护猪的健康和提高生产力提供了有希望的途径。
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引用次数: 0
Physical biomedical science 物理生物医学
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2025.10.001
Zhou Li
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引用次数: 0
Effective disposal and remediation of chemical agents with designer living biofilm materials in soil and water 设计生物膜材料对土壤和水中化学制剂的有效处理和修复
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2023.04.007
Xuan Guo , Suying Liu , Lei Zhou , Bin Xue , Yongpeng Huang , Junwen Li , Jinyi Zhong , Chao Zhong
Chemical agents (CAs) and their analogues, as representative persistent organic pollutants, are of serious global concerns and can have devastating impacts on environments and human beings. Enzymes used for decontamination of such chemical pollutions often lack high efficacy and robustness against environmental pressures, thereby limiting their practical application in bioremediation. Here, we report living materials based on genetically engineered biofilms that exhibit remarkable enzymatic activities, superior environmental tolerance, self-regeneration, recyclable usage, and tunable functionality. We show that the designer living materials can degrade CAs and pesticides with high efficacy in an eco-friendly manner, and our systems enable actual elimination of CAs pollution in water and soil. The degradation capacity of the designer living materials can achieve more than 95% for 5 mg/ml HD, 5 mg/ml GD and 5 mg/ml VX within 60 min under laboratory conditions, and the turnover numbers of the designer living materials for HD, GD, and VX have increased by more than 1.3 times compared with free enzymes. In addition, the relative activities of the designer living materials remained almost unchanged after 5 recycles, retaining over 95% of their initial catalytic activities even after the final cycle. Combining the adhesive engineered biofilm living materials with electropositive granule media to form a bifunctional composite material, we further demonstrate coinstantaneous removal of biological and chemical pollutants in environmental water. Our work thus establishes a general approach to improve the robustness of enzymes against environmental pressures and provides a sustainable method for decontamination of chemical and biological pollutions.
化学剂及其类似物作为具有代表性的持久性有机污染物,已成为全球关注的焦点,对环境和人类造成了毁灭性的影响。用于净化这类化学污染的酶往往缺乏高效和抗环境压力的稳健性,从而限制了它们在生物修复中的实际应用。在这里,我们报道了基于基因工程生物膜的生物材料,这些材料表现出显著的酶活性、优越的环境耐受性、自我再生、可回收利用和可调节的功能。我们的研究表明,设计的生物材料可以高效、环保地降解CAs和农药,我们的系统可以真正消除水和土壤中的CAs污染。在实验室条件下,设计活性材料对5mg /ml HD、5mg /ml GD、5mg /ml VX在60min内的降解能力可达到95%以上,设计活性材料对HD、GD、VX的周转率比游离酶提高了1.3倍以上。此外,经过5次循环后,设计活性材料的相对活性几乎没有变化,即使在最后一次循环后,也保持了95%以上的初始催化活性。将胶粘剂工程生物膜生物材料与正电颗粒介质结合,形成双功能复合材料,进一步展示了同时去除环境水中的生物和化学污染物。因此,我们的工作建立了一种提高酶对环境压力的稳健性的一般方法,并为化学和生物污染的净化提供了一种可持续的方法。
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引用次数: 0
Inner ear organoids: Recent progress and potential applications 内耳有机体:最新进展和潜在应用
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2023.07.013
Yiyun Lou , Yaoqian Liu , Mingxuan Wu , Gaogan Jia , Mingyu Xia , Wenyan Li
The inner ear is one of the most complicated structures that harbor organs for the perception of sound and balance, which is deep in the temporal bone and challenging to operate. Organoids serve as promising platforms for understanding developmental processes and pathological dysfunctions and discovering therapeutic drugs and gene therapy strategies for disorders in the inner ear. To better understand the origin and application value of organoids, we reviewed the developmental history and advancement of inner ear organoid research. We summarized the cell sources of organoids and the matrices supporting their formation. The history of the research on inner ear organoids derived from pluripotent stem cells (PSCs) and primary progenitor cells has been clarified in detail. We elaborated on the applications of organoids in inner ear development, hereditary deafness modeling, and hair cell (HC) regeneration strategy formulation. Finally, we mentioned limitations of the current culture methods and applications of inner ear organoids, and described several prospects for optimizing next-generation organoids of the inner ear for potential translational applications.
内耳是最复杂的结构之一,它位于颞骨深处,具有感知声音和平衡的器官,具有挑战性。类器官是了解内耳发育过程和病理功能障碍以及发现治疗药物和基因治疗策略的有希望的平台。为了更好地了解类器官的起源和应用价值,本文综述了内耳类器官的发展历史和研究进展。本文综述了类器官的细胞来源及支持其形成的基质。本文详细阐述了多能干细胞(PSCs)和原代祖细胞衍生的内耳类器官的研究历史。我们详细阐述了类器官在内耳发育、遗传性耳聋建模和毛细胞(HC)再生策略制定中的应用。最后,我们指出了目前内耳类器官培养方法和应用的局限性,并描述了优化下一代内耳类器官以实现潜在转化应用的几个前景。
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引用次数: 0
Research on silicoaluminate-based low-carbon cementitious material—A state-of-the-art review 硅铝酸盐基低碳水泥基材料研究--最新进展综述
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2024.04.020
Jinyang Jiang , Shiyu Sui , Zhiyong Liu , Fengjuan Wang , Guoqing Geng
The green and low-carbon production of cement is the essential pathway for infrastructure sustainability and the implementation of a dual-carbon strategy. To mitigate the increasingly criticized environmental impact of cement production, silicoaluminate-based cementitious materials utilizing pozzolanic waste and low-grade materials have received considerable attention in recent years. They not only reduce CO2 emissions but also decrease the reliance on nonrenewable resources, thus promoting the sustainable development of building materials. This paper provides a comprehensive review of the latest research progress on low-carbon cementitious materials based on silicoaluminate and limestone. First, an introduction to the current low-carbon cementitious materials is provided that helps address the necessity of exploring silicoaluminate-based low-carbon cementitious materials. Then, the hydration and microstructure evolution, mechanical properties, and durability characteristics of these new cementitious materials are analyzed. Furthermore, the net benefits of this low-carbon material sustainability are summarized from a life-cycle perspective. Finally, the paper suggests some directions for future research in this field.
绿色低碳水泥生产是基础设施可持续发展和实施双碳战略的重要途径。为了减轻水泥生产对环境日益严重的影响,近年来,利用火山灰废物和低品位材料的硅铝酸盐基胶凝材料受到了相当大的关注。既减少了二氧化碳的排放,又减少了对不可再生资源的依赖,从而促进了建筑材料的可持续发展。本文综述了以硅铝酸盐和石灰岩为基材的低碳胶凝材料的最新研究进展。首先,介绍了目前低碳胶凝材料,有助于解决探索硅铝酸盐基低碳胶凝材料的必要性。分析了新型胶凝材料的水化、微观结构演变、力学性能和耐久性特征。此外,从生命周期的角度总结了这种低碳材料可持续性的净效益。最后,对该领域今后的研究方向进行了展望。
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引用次数: 0
Key role of microbial necromass and iron minerals in retaining micronutrients and facilitating biological nitrogen fixation in paddy soils 微生物坏死物质和铁矿物在保留微量营养元素和促进稻田土壤生物固氮方面的关键作用
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2024.02.007
Li-Xin Xu , Fei Wang , Yao Yao , Minjie Yao , Yakov Kuzyakov , Guang-Hui Yu , Cong-Qiang Liu
Paddy fields, as the largest anthropogenic wetlands on Earth, face a high risk of micronutrient loss through surface runoff and leaching due to their frequent irrigation-drainage cycles, as well as removal with crop harvest. While micronutrient’s losses largely impede biological nitrogen fixation (BNF) in soils, agricultural practices and mechanisms that retain micronutrients and thus increase BNF in paddy soils remain underexplored. Here we showed that the long-term (40 years) application of fertilizers increased the contents of microbial necromass in paddy soils by 20%–43% compared to the unfertilized control. In particular, long-term organic fertilizations increased poorly crystalline minerals through intensifying mineral weathering, which further contributed to the increased stable carbon burials in paddy soils. Synchrotron radiation based spectromicroscopy analysis provided direct evidence demonstrating a differential control of hydroxyl functional groups from mineral surfaces on C functional groups at the submicron scale in paddy soils. Notably, microbial necromass and short-range ordered minerals had a strong correlation with the content and bioavailability of micronutrients in paddy soils, indicating their key roles in the retention of micronutrients. Metagenomic sequencing analysis further indicated that the content and bioavailability of micronutrients were strongly correlated with the abundance of the key N-fixing genera (i.e., Azospirillum and Bradyrhizobium). Unexpectedly, structural equation modeling (SEM) identified that microbial necromass exerted the strongest control on N-fixing genera, highlighting an underappreciated role of microbial necromass as a reservoir of micronutrients. Based on micronutrient's bioavailability and metagenomic sequencing, we conclude that micronutrients are the key factor for BNF in paddy soils, offering significant implications for managing BNF in paddy soils.
水田作为地球上最大的人为湿地,由于其频繁的灌溉-排水循环以及随着作物收获而被清除,水田面临着通过地表径流和淋滤而导致微量营养素流失的高风险。虽然微量元素的损失在很大程度上阻碍了土壤的生物固氮(BNF),但保持微量元素从而增加水稻土生物固氮的农业实践和机制仍未得到充分探索。本研究表明,长期(40年)施用化肥使水稻土微生物坏死块含量比未施肥的对照增加了20%-43%。特别是,长期有机肥通过强化矿物风化作用增加了低结晶矿物,进一步增加了水稻土的稳定碳埋藏。基于同步辐射的光谱显微镜分析提供了直接证据,证明了在亚微米尺度上水稻土中矿物表面羟基官能团对C官能团的差异控制。值得注意的是,微生物坏死团块和短程有序矿物质与水稻土中微量元素的含量和生物有效性有很强的相关性,表明它们在微量元素的保留中起着关键作用。宏基因组测序分析进一步表明,微量营养素的含量和生物利用度与固氮菌和慢生根瘤菌等关键固氮菌的丰度密切相关。出乎意料的是,结构方程模型(SEM)发现微生物坏死块对固氮属施加了最强的控制,突出了微生物坏死块作为微量营养素储存库的作用。基于微量元素的生物有效性和宏基因组测序,我们得出结论,微量元素是水稻土BNF的关键因素,为水稻土BNF的管理提供了重要意义。
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引用次数: 0
Biohybrid CO2 electrolysis under external mode: Using pure formic acid extracted from CO2 electroreduction for diverse microbial conversion 外部模式下的生物混合二氧化碳电解:利用从二氧化碳电还原中提取的纯甲酸进行多种微生物转化
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2024.02.008
Na Chu , Xiaobing Wu , Ziyue Zhao , Xue Zheng , Yilin Lu , Ying Pu , Yue Wang , Jiayi Cai , Lixia Zhang , Xiaohong He , Daping Li , Raymond Jianxiong Zeng , Yangyang Yu , Yong Jiang
The demand for converting CO2 into fuels or chemicals is on the rise to achieve a carbon-efficient circular economy. Biohybrid CO2 electrolysis shows potential for increasing production rates and diversifying product spectra by combining electrocatalysts and microbial catalysts. However, it is important to note that utilizing a shared catholyte for biohybrid CO2 electrolysis has not demonstrated significant performance improvements to date. In this study, we developed a biohybrid CO2 electrolysis system utilizing a solid electrolyte operating in an external mode. The produced formic acid was extracted and used as an intermediate for microbial conversion. Impressively, the solid-electrolyte CO2 electrolysers obtained a remarkable total Faradic efficiency of 81.4% for formic acid production. In-situ mechanism studies unveiled metallic tin as the probable real active site, prompting further exploration of strategies to boost the activity and stability of electrocatalysts. In the bioconversion step, we achieved a noteworthy 8-day duration for generating bioelectricity, nearly 100% electron recovery for biomethane production, and 90.8% for acetate generation. Additionally, when ethanol was co-fed, a C6 specificity of 41.1% was observed for the generation of medium-chain fatty acids (MCFAs). This study presents groundbreaking experimental data that demonstrates the numerous advantages of utilizing hybrid systems as advanced synthesis techniques.
为实现低碳循环经济,将二氧化碳转化为燃料或化学品的需求正在上升。生物混合CO2电解通过结合电催化剂和微生物催化剂,显示出提高生产速率和多样化产品光谱的潜力。然而,值得注意的是,迄今为止,使用共享阴极液进行生物混合CO2电解尚未显示出显着的性能改进。在这项研究中,我们开发了一种生物混合CO2电解系统,利用固体电解质在外部模式下工作。提取生成的甲酸作为微生物转化的中间体。令人印象深刻的是,固体电解质CO2电解槽在甲酸生产中获得了81.4%的显着总法拉迪效率。原位机理研究揭示了金属锡可能是电催化剂的真正活性位点,进一步探索了提高电催化剂活性和稳定性的策略。在生物转化步骤中,我们实现了8天的生物发电持续时间,生物甲烷生产的电子回收率接近100%,醋酸盐生产的电子回收率为90.8%。此外,当乙醇共投喂时,观察到C6对中链脂肪酸(MCFAs)产生的特异性为41.1%。这项研究提出了突破性的实验数据,证明了利用混合系统作为先进合成技术的众多优势。
{"title":"Biohybrid CO2 electrolysis under external mode: Using pure formic acid extracted from CO2 electroreduction for diverse microbial conversion","authors":"Na Chu ,&nbsp;Xiaobing Wu ,&nbsp;Ziyue Zhao ,&nbsp;Xue Zheng ,&nbsp;Yilin Lu ,&nbsp;Ying Pu ,&nbsp;Yue Wang ,&nbsp;Jiayi Cai ,&nbsp;Lixia Zhang ,&nbsp;Xiaohong He ,&nbsp;Daping Li ,&nbsp;Raymond Jianxiong Zeng ,&nbsp;Yangyang Yu ,&nbsp;Yong Jiang","doi":"10.1016/j.fmre.2024.02.008","DOIUrl":"10.1016/j.fmre.2024.02.008","url":null,"abstract":"<div><div>The demand for converting CO<sub>2</sub> into fuels or chemicals is on the rise to achieve a carbon-efficient circular economy. Biohybrid CO<sub>2</sub> electrolysis shows potential for increasing production rates and diversifying product spectra by combining electrocatalysts and microbial catalysts. However, it is important to note that utilizing a shared catholyte for biohybrid CO<sub>2</sub> electrolysis has not demonstrated significant performance improvements to date. In this study, we developed a biohybrid CO<sub>2</sub> electrolysis system utilizing a solid electrolyte operating in an external mode. The produced formic acid was extracted and used as an intermediate for microbial conversion. Impressively, the solid-electrolyte CO<sub>2</sub> electrolysers obtained a remarkable total Faradic efficiency of 81.4% for formic acid production. <em>In-situ</em> mechanism studies unveiled metallic tin as the probable real active site, prompting further exploration of strategies to boost the activity and stability of electrocatalysts. In the bioconversion step, we achieved a noteworthy 8-day duration for generating bioelectricity, nearly 100% electron recovery for biomethane production, and 90.8% for acetate generation. Additionally, when ethanol was co-fed, a C<sub>6</sub> specificity of 41.1% was observed for the generation of medium-chain fatty acids (MCFAs). This study presents groundbreaking experimental data that demonstrates the numerous advantages of utilizing hybrid systems as advanced synthesis techniques.</div></div>","PeriodicalId":34602,"journal":{"name":"Fundamental Research","volume":"5 6","pages":"Pages 2597-2606"},"PeriodicalIF":6.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140091403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can competitive effects and responses of alien and native species predict invasion outcomes? 外来物种和本地物种的竞争效应和反应能否预测入侵结果?
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2024.05.001
Tingting Wu , Yuanzhi Li , Marc W. Cadotte , Oscar Godoy , Chengjin Chu
The relative competitive ability of native and alien species, which consists of competitive effect (CE) and response (CR), has often been invoked as a key determinant of invasion success. Previous studies have reported that an alien species with a high CE and/or a low CR would successfully invade a native species. However, no studies have yet empirically examined the hypothesis or tested the consistency of invasion outcomes predicted by the CE-CR framework and modern species coexistence theory (MCT). To fill this research gap, we conducted a pairwise competition experiment between five alien and five native species, quantified CE and CR based on their biomass in the absence and presence of one competitor, and predicted invasion outcomes based on both CE-CR and MCT frameworks. We have demonstrated theoretically that the CE and CR frequently measured in previous work are only approximations of interspecific competitive coefficients, and thus could not completely predict the invasion outcomes. As we expected, the invasion outcomes predicted by the CE-CR framework were partially consistent with the predictions by the MCT framework. Specifically, aliens with low CR and high CE tended to exclude natives, while aliens with high CR and low CE tended to be excluded by natives according to MCT. In contrast, pairs of stable coexistence and priority effects did not conform to the theoretical expectation. Despite the theoretical defects of the CE-CR framework, it can provide some useful value in predicting the invasion outcomes, especially when intrinsic growth rate and intraspecific competition coefficients are not available. Our study is the first to compare invasion outcomes separately derived from qualitative (the CE-CR framework) and quantitative (the MCT framework) methods. We recommend that future research should adopt quantitative approaches such as MCT as far as possible, to more comprehensively understand and predict the biotic outcomes of interacting species.
本地和外来物种的相对竞争能力,包括竞争效应(CE)和反应(CR),通常被认为是入侵成功的关键决定因素。以前的研究报道了具有高CE和/或低CR的外来物种能够成功入侵本地物种。然而,目前还没有研究对这一假设进行实证检验,也没有研究对CE-CR框架与现代物种共存理论(MCT)预测的入侵结果的一致性进行检验。为了填补这一研究空白,我们在5种外来物种和5种本地物种之间进行了配对竞争实验,根据缺乏和存在一个竞争对手时的生物量量化了CE和CR,并基于CE-CR和MCT框架预测了入侵结果。我们已经从理论上证明,以往工作中经常测量的CE和CR只是种间竞争系数的近似值,因此不能完全预测入侵结果。正如我们所料,CE-CR框架预测的入侵结果与MCT框架的预测部分一致。具体来说,根据MCT,低CR和高CE的外来者倾向于排斥本地人,而高CR和低CE的外来者倾向于被本地人排斥。而对稳定共存和优先效应则不符合理论预期。尽管CE-CR框架存在理论缺陷,但它在预测入侵结果方面具有一定的实用价值,特别是在内在生长速率和种内竞争系数不确定的情况下。我们的研究首次比较了定性(CE-CR框架)和定量(MCT框架)方法分别得出的入侵结果。我们建议未来的研究应尽可能采用MCT等定量方法,以更全面地了解和预测相互作用物种的生物结果。
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引用次数: 0
Multicolor management of smart fluorescent polymeric hydrogels 智能荧光聚合物水凝胶的多色管理
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2024.07.006
Muqing Si , Wei Lu , Tao Chen
Fluorescent polymeric hydrogels (FPHs) are rising stars of luminescent materials because of their considerable prospects in a wide range of advancing domains. However, challenges exist in broadening their color tunability, which is the key to developing multicolor FPHs (MFPHs) for actual applications in cutting-edge frontiers. In this perspective, we summarize the state-of-the-art strategies for fabricating MFPHs and discuss the remaining challenges.
荧光聚合物水凝胶(FPHs)是发光材料领域的一颗冉冉升起的新星,在许多先进的领域具有广阔的前景。然而,扩大其颜色可调性存在挑战,这是开发多色FPHs (MFPHs)在前沿领域实际应用的关键。从这个角度来看,我们总结了制造MFPHs的最新策略,并讨论了剩余的挑战。
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引用次数: 0
Management and utilization of triplet excitons in organic optoelectronic devices 有机光电器件中三重态激子的管理与利用
IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Pub Date : 2025-11-01 DOI: 10.1016/j.fmre.2024.05.009
Can Gao , Zhagen Miao , Wallace W.H. Wong , Trevor A. Smith , Shih-Chun Lo , Wenping Hu , Ebinazar B. Namdas , Huanli Dong
Organic optoelectronics have received tremendous attentions in the past few decades, which are benefitting from the rapid development of organic semiconductors and their unique merits such as flexible design, low-cost production, and rich optoelectronic properties. Triplet excitons with two parallel electronic spins generated in the organic optoelectronic devices have significant effects on the device performance. In this review, a timely summary and brief discussion of the management and utilization of the triplet excitons in organic optoelectronic devices are given. We firstly summarized the studies and applications of triplet excitons in optical-to-electrical and electrical-to-optical devices, including solar cells, organic light-emitting diodes (OLEDs) and organic light-emitting transistors (OLETs). Particularly, the pioneering advances of triplet management in OLETs are reviewed for the first time. Additionally, two possible strategies for breaking the theoretical limit of internal quantum efficiency (IQE) in electroluminescent devices by fully taking the advantages of triplet excitons are proposed. Finally, the challenges and perspective of existing issues in this field for further improving the performance of optoelectronic devices and other related research directions are also provided.
近几十年来,有机光电子学受到了人们的极大关注,这得益于有机半导体的快速发展及其设计灵活、生产成本低、光电性能丰富等独特优点。有机光电器件中产生的具有两个平行电子自旋的三重态激子对器件性能有重要影响。本文对有机光电器件中三重态激子的管理和利用进行了及时的总结和简要的讨论。本文首先综述了三重态激子在光电和电光器件中的研究和应用,包括太阳能电池、有机发光二极管和有机发光晶体管。特别地,本文首次回顾了OLETs中三元组管理的开创性进展。此外,本文还提出了利用三重态激子的优势来突破电致发光器件内量子效率理论极限的两种可能策略。最后,对该领域存在的问题提出了挑战和展望,为进一步提高光电器件性能和其他相关研究方向提供了参考。
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引用次数: 0
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