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2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems最新文献

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Electrorotation: Diagnostic Tool for Abnormality of Marine Phytoplankton Cells 电旋:海洋浮游植物细胞异常的诊断工具
P. Wanichapichart, T. Wongluksanapan, L. Khooburat
This work proposes a method to estimate cell dielectric properties using a rotating electric field. Signals given to four platinum electrodes were from a phase shift unit, which splits an input signal into four of pi/2 phase difference. The unit performs well under frequency below 5 MHz. Rotation patterns of pretreated Tetraselmis sp. were utilized to reveal dielectric information of the cells. The rotation of boiled cells diminished at the lower frequency range, while that of the arsenic pretreated cells was smaller than that of the control when higher arsenic concentration was used. The specific membrane conductance was increased from 0.5 kS.m-1 for the control to 90 kS.m-1 boiled cells. Pretreated cells with arsenic solution at 10 to 100 ppm levels increased the membrane conductance to 8.8 kS.m-1, much less effect compared to the boiled cells. Moreover, 24 hrs pretreatment was long enough for arsenic to penetrate the membrane, and the cytoplasmic permittivity was reduced from 39epsivO to about 13e0, independent of the arsenic levels used. The study can distinguish the viability from the non-viability cells by carefully selected field, frequency, and solution conductivity.
本文提出了一种利用旋转电场估计电池介电特性的方法。给四个铂电极的信号来自相移装置,它将输入信号分成四个相位差为pi/2的相位差。在5兆赫以下的频率下性能良好。利用预处理过的Tetraselmis sp.的旋转模式来揭示细胞的介电信息。在较低的频率范围内,水煮细胞的旋转减弱,而在较高的砷浓度下,砷预处理细胞的旋转小于对照。比膜电导从0.5 k增加。m-1为控制至90 k。M-1煮沸细胞。用10至100 ppm浓度的砷溶液预处理细胞,使膜电导率提高到8.8 k。M-1,与煮沸的细胞相比效果要小得多。此外,24小时的预处理时间足以使砷穿透膜,并且细胞质介电常数从39epsivO降至13e0左右,与使用的砷水平无关。该研究可以通过精心选择的电场、频率和溶液电导率来区分有活力和无活力的细胞。
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引用次数: 5
Extracting the Young's Modulus and Stress Gradient of Thin Films from the Pull-in Voltage of a Micro Curled Cantilever Beam 从微卷曲悬臂梁的拉入电压中提取薄膜的杨氏模量和应力梯度
Yuh-Chung Hu, C. Wei, C. Hsiao, D.T.W. Li
This paper presents a high-precision algorithm for extracting the Young's modulus and stress gradient of thin films from the pull-in voltage measurement of a micro curled cantilever beam made of thin film materials. The algorithm considers the important issues including the fringing fields, the electromechanical coupling, and the stress-induced initial curling of the micro structures. The deviation of the extracted Young's modulus and stress gradient from the reality are below 4%. The present algorithm is very applicable to the wafer-lever testing of MEMS devices since the driving and response signals are both electric, the present algorithm could be accomplished using existing semiconductor testing equipments through probing on the bonding pads of devices.
本文提出了一种从薄膜材料微卷曲悬臂梁的拉入电压测量中提取薄膜杨氏模量和应力梯度的高精度算法。该算法考虑了微结构的边缘场、机电耦合和应力致初始卷曲等重要问题。提取的杨氏模量和应力梯度与实际的偏差在4%以下。由于驱动信号和响应信号都是电信号,本算法非常适用于MEMS器件的晶级测试,可以利用现有的半导体测试设备,通过探测器件的键合盘来完成。
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引用次数: 4
A Drug Delivery System Based on Polymer Nanotubes 基于聚合物纳米管的药物输送系统
K. Koombua, R. Pidaparti, G. Tepper
A generic drug delivery system based on polymer nanotubes was design. Polymer nanotube bundles were used as drug delivery channels within a device. Because this device is very small and biocompatible, it can be implanted at any specific infectious location. The drug diffusion within the device was analyzed using the finite element method and the diffusion rate was calculated using Fick's law. The results showed the possibility of using this polymer-nanotube device as a drug delivery system that can provide a constant delivery rate and target a specific location.
设计了一种基于聚合物纳米管的非专利给药系统。采用高分子纳米管束作为药物输送通道。因为这个装置非常小并且具有生物相容性,它可以被植入任何特定的感染部位。用有限元法分析了药物在装置内的扩散,用菲克定律计算了扩散速率。结果表明,使用这种聚合物纳米管装置作为药物递送系统的可能性,可以提供恒定的递送速率并针对特定的位置。
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引用次数: 5
Acoustic Analysis of Single-Walled Carbon Nanotube-based Vacuum Sensor 单壁碳纳米管真空传感器的声学分析
Yi Zhang, Hang Guo
In this paper, the acoustic wave propagation of single walled carbon nanotube (SWCNT) is investigated with a look into their applications in vacuum sensors at the microscale. First, the carbon nanotube in fixed-free is simulated by a continuum elastic shell modeling to analyze to the wave propagation of single walled carbon nanotubes. The sensing principle of the single-walled carbon nanotube-based vacuum sensor is based on the resonant frequency shift of a carbon nanotube acoustic bridge driven by resonant ultrasound spectroscopy (RUS) when it is subjected to sub-atmosphere force or gas pressure. The results indicate that the quality factor of the SWCNT bridge can be very high. The simulation analysis results show that the modeling approach is appropriated to describe the acoustic wave propagation of SWNT, which may be adopted as a theoretical reference for vacuum sensor design.
本文研究了单壁碳纳米管(SWCNT)的声波传播特性,并探讨了其在真空传感器中的应用。首先,采用连续弹性壳模型对固定-自由状态下的碳纳米管进行了模拟,分析了单壁碳纳米管的波传播特性。单壁碳纳米管真空传感器的传感原理是基于共振超声光谱(RUS)驱动的碳纳米管声桥在受到亚大气力或气体压力时的谐振频移。结果表明,纳米碳管电桥的质量系数可以非常高。仿真分析结果表明,该建模方法能够较好地描述SWNT的声波传播过程,可为真空传感器的设计提供理论参考。
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引用次数: 2
The application of Iron Oxide magnetic nanoparticles to improve the binding efficiency of the IgG and Thiol SAMs 应用氧化铁磁性纳米颗粒提高IgG和硫醇类SAMs的结合效率
D. Yao, Chun-Yi Lin, Fang-Gang Tseng
Superparamagnetic nanoparticles have been fabricated successfully, which are composed of Fe3O4 by using wet chemical co-precipitate method. The nanoparticles were functionalized on the surface by conjugated with the abti-Rabbit IgG. In the recently research, we try to use this system to approach the work which is to increase the reaction efficiency between antibodies and antigens by applying magnetic fields to alternate the binding samples in solution. The applied magnetic fields are produced by electro-magnets with AC or DC input. In the preliminary experiment, the antibodies were reacted with the carboxyl group Thiol SAMs that were modified on the glass chip with gold film. The surface plasma resonance (SPR) was used to detect the binding number of antibodies on the chip. The binding efficiency could be further calculated. The results showed the binding efficiency could be improved by using superparamagnetic nanoparticles with applying magnetic fields.
采用湿化学共沉淀法成功制备了由Fe3O4组成的超顺磁性纳米颗粒。纳米颗粒通过与抗兔IgG偶联在表面实现功能化。在最近的研究中,我们尝试使用该系统来研究通过施加磁场交替结合样品来提高抗体和抗原之间的反应效率的工作。外加磁场由交流或直流输入的电磁铁产生。在初步实验中,抗体与羧基硫醇SAMs反应,并在玻璃芯片上用金膜修饰。采用表面等离子体共振(SPR)检测抗体在芯片上的结合数。结合效率可以进一步计算。结果表明,在外加磁场的作用下,超顺磁性纳米颗粒可以提高其结合效率。
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引用次数: 1
Fabrication of Nanowire Arrays Using Diblock Copolymer 用双嵌段共聚物制备纳米线阵列
V. Sudha Rani, C.O. Kim, B. Parvatheeswara Rao, S. Yoon, Cheolgi Kim
Electrodeposited Co nanowires were grown on self assembled diblock copolymer nanoporous templates. While keeping the template pore size and electrolyte pH value constant at 13.7 nm and 3.82, respectively, the DC current density (5 mA/cm2 and 50 mA/cm2) and time of deposition (50s, 100s, 150s and 200s) were varied as an attempt to obtain nanowires of varied aspect ratios and morphologies. It was observed that height of the nanowire linearly enhances with the time of the electrodeposition. SEM images of the samples indicate that the template pores were completely filled during deposition when the current density was set 50 mA/cm2. Excess times of deposition produced a thin layer of the deposited material on top of the porous template. Magnetic hysteresis properties of the generated nanowires were examined by vibration sample magnetometry. The loops displayed are highly square with coercivities of few tens of oersteds. The magnetization of the Co nanowires enhances as the height of the wires increases. The results were analyzed to understand the influence of current density on the growth of nanowires.
在自组装的二嵌段共聚物纳米孔模板上生长电沉积钴纳米线。在保持模板孔径和电解液pH分别为13.7 nm和3.82 nm的情况下,改变直流电流密度(5 mA/cm2和50 mA/cm2)和沉积时间(50s, 1000s, 150s和200s),试图获得不同宽高比和形貌的纳米线。观察到纳米线的高度随电沉积时间的增加呈线性增加。样品的SEM图像表明,当电流密度为50 mA/cm2时,模板孔在沉积过程中被完全填充。过多的沉积次数会在多孔模板的顶部产生一层薄薄的沉积材料。用振动样品磁强计测试了制备的纳米线的磁滞特性。所显示的环路是高度方形的,矫顽力只有几十伏。钴纳米线的磁化强度随高度的增加而增强。对实验结果进行分析,了解电流密度对纳米线生长的影响。
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引用次数: 3
Blue Emission Mechanism of NPB/ZnSe Hybrid Structure NPB/ZnSe杂化结构蓝色发射机理研究
N. Kayunkid, A. Keawprajak, A. Jaruwanawat, J. Nukeaw
The electrical and optical properties of organic-inorganic hybrid light emitting diodes (HLED) have been investigated. The HLED is consisted of organic material N,N'-di(naphthalene-l-yl)-N,N'- diphenyl-benzidine (NPB) as a hole transport layer and inorganic material zinc selenide (ZnSe) as an electron transport layer and emitting layer as well. The electrical and optical properties have been characterized by current-voltage measurement and electroluminescence (EL) spectroscopy, respectively. The current of HLED decreases with increasing ZnSe thickness, while the threshold voltage increases. The EL spectrum exhibits two peaks at 457 nm and 500 nm, due to electron-hole recombination from energy gap of ZnSe and recombination from defect states in ZnSe layer, respectively. The emission mechanism is described by electric field in organic and inorganic layers.
研究了有机-无机混合发光二极管(HLED)的电学和光学特性。该发光二极管由有机材料N,N′-二(萘-l-基)-N,N′-二苯基联苯胺(NPB)作为空穴传输层和无机材料硒化锌(ZnSe)作为电子传输层和发射层组成。电学和光学性质分别用电流-电压测量和电致发光(EL)光谱进行了表征。随着ZnSe厚度的增加,led电流减小,阈值电压增大。EL谱在457nm和500nm处出现两个峰,分别是由于ZnSe能隙的电子空穴复合和ZnSe层缺陷态的电子空穴复合。用电场描述了有机层和无机层的发射机理。
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引用次数: 3
On-Chip Continuous Blood Cell Subtype Separation by Deterministic Lateral Displacement 用确定性横向位移法在芯片上连续分离血细胞亚型
Nan Li, Daniel T. Kamei, Chih-Ming Ho
This paper presents a microfluidic device for continuous human blood cell subtype separation using the deterministic lateral displacement principle. Based on their significant size and shape differences, three major cell types of human whole blood - platelets, red blood cells and white blood cells -were demonstrated to be directly separated using a two-stage separation strategy. Even though all white blood cells are spherical and have diameters within a narrow range (8-20mum), the initial limitation for using this principle to separate white blood cell subtypes was conquered by attaching larger polystyrene microbeads to one of the subtypes to amplify the size differences. Specifically, continuous separation of human CD4+ T helper lymphocytes from other white blood cell subtypes was achieved with high purity and recovery due to the underlying high affinity and high specificity of the antigen-antibody interaction used to attach the microbeads to the lymphocytes. With our novel approach, the pure population of one blood cell subtype can be effectively isolated by exploring the deterministic lateral displacement principle, which has the advantages of the simplicity, high speed and high resolution. Because many cells express unique surface markers, this method can theoretically be applied to separate any target cell type from a heterogeneous mixture for downstream analysis.
本文介绍了一种利用确定性横向位移原理连续分离人血细胞亚型的微流控装置。基于它们显著的大小和形状差异,人类全血的三种主要细胞类型——血小板、红细胞和白细胞——被证明可以使用两阶段分离策略直接分离。尽管所有的白细胞都是球形的,直径范围也很窄(8- 20mm),但通过将更大的聚苯乙烯微珠附着在其中一种亚型上,扩大白细胞的大小差异,克服了利用这一原理分离白细胞亚型的最初限制。具体来说,由于用于将微珠附着在淋巴细胞上的抗原-抗体相互作用具有潜在的高亲和力和高特异性,因此可以实现人类CD4+ T辅助淋巴细胞与其他白细胞亚型的连续分离,并且具有高纯度和高回收率。该方法通过探索确定性横向位移原理,可以有效地分离单一血细胞亚型的纯群体,具有简单、快速和高分辨率的优点。由于许多细胞表达独特的表面标记,理论上这种方法可以应用于从异质混合物中分离任何靶细胞类型进行下游分析。
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引用次数: 40
Natural Frequencies of Single-Walled Carbon Nanotubes 单壁碳纳米管的固有频率
U. Lee, Hyukjin Oh, S. You
Fundamental natural frequencies of armchair single-walled carbon nanotubes (SWCNTs) are evaluated in this paper. As there is no universal agreement on the exact wall thickness of a SWCNT, some different wall thicknesses have been assumed by most of researchers to report a wide range of different elastic constants for a SWCNT. Thus, to compute the effective structural properties of SWCNTs needed for the evaluation of their fundamental natural frequencies, without needing to assume the controversial wall thickness, we adopt a new continuum modeling method developed in our previous study based on the energy equivalence principle.
本文对扶手型单壁碳纳米管(SWCNTs)的基本固有频率进行了评估。由于对单壁碳纳米管的确切壁厚没有统一的看法,大多数研究人员都假设了不同的壁厚,以报告不同的单壁碳纳米管弹性常数。因此,为了计算评估SWCNTs基本固有频率所需的有效结构特性,而不需要假设有争议的壁厚,我们采用了我们之前基于能量等效原理开发的新的连续介质建模方法。
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引用次数: 3
Fabrication of a Complicated Heat Transfer Microchannel System for CPU Cooling Study 一种用于CPU冷却的复杂传热微通道系统的制作研究
H.T. Chen, C.W. Liu, S.G. Liu, C.S. Yang, C. Gau
Fabrication of a temperature sensor array and a heater in a complicated heat transfer microchannel system, on a glass substrate, is presented. In addition to the glass substrate, low thermal conductivity materials such as SU-8, PMMA plate are selected to form the micro channel wall to provide good thermal insulation. Both the titanium and the platinum are deposited sequentially on a glass plate and made into heater and sensors, respectively. Lift-off method is used to obtain the desired pattern for heater and sensors. The fabrication process is much simpler than those reported in literature. Design consideration and fabrication techniques involved in this processes is discussed. Finally, validation of the heaters and sensors fabricated and a measurement of the heat transfer coefficient distributions inside the micro channel is presented.
介绍了在玻璃基板上制造复杂传热微通道系统中的温度传感器阵列和加热器。除了玻璃基板外,还选择了低导热材料如SU-8、PMMA板等形成微通道壁,以提供良好的隔热效果。钛和铂依次沉积在玻璃板上,分别制成加热器和传感器。采用升离法获得加热器和传感器所需的模式。制作过程比文献报道的要简单得多。讨论了该工艺中涉及的设计考虑和制造技术。最后,对所制作的加热器和传感器进行了验证,并测量了微通道内的传热系数分布。
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引用次数: 1
期刊
2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems
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