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2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems最新文献

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Nanomechanical Chemical Sensor Platform 纳米机械化学传感器平台
Si-Hyung Lim, J. Jaworski, S. Satyanarayana, F. Wang, D. Raorane, Seung-Wuk Lee, A. Majumdar
For gas phase chemical sensing, we have developed a selective, sensitive and portable sensing platform, which integrates bio receptors, chemo-mechanical sensor array, and electrical readout circuits. The biggest challenge in chemical sensors is selectivity of a receptor to its respective target molecule against a background of various interfering agents. For target specific receptors, sequence-specific recognition motifs have been identified through directed evolution methods, called phage display. We have demonstrated and updated a parylene micromembrane surface stress sensor array which uses capacitive signal readout. For a fully integrated sensor platform, a portable chemical sensing board has been built.
对于气相化学传感,我们开发了一种选择性,灵敏度和便携式传感平台,该平台集成了生物受体,化学机械传感器阵列和电子读出电路。化学传感器面临的最大挑战是在各种干扰剂的背景下,受体对其各自的靶分子的选择性。对于目标特异性受体,序列特异性识别基序已经通过定向进化方法确定,称为噬菌体展示。我们展示并更新了一种使用电容式信号读出的聚对二甲苯微膜表面应力传感器阵列。为了实现完全集成的传感器平台,构建了便携式化学传感板。
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引用次数: 5
Design and system-level simulation of a capacitive dual axis accelerometer 电容式双轴加速度计的设计与系统级仿真
Weiping Chen, J. Ding, Xiaowei Liu, Chao Wang
A system-level model of a bulk micromachined dual axis accelerometer is presented. The accelerometer has only one inertial mass, symmetrically suspended by four pairs of folded elastic beams. The size of the fabricated accelerometer is 5.4times5.4 mm2. The displacement change of the inertial mass is converted to the change of differential capacitance between active combs and fixed combs. Generally, the input acceleration is mixed with the x-axis and the y-axis. In order to separate and pick off the mixed signal, the frequency-division method is adopted in the interface circuit. The paper details the Simulink model, which is used to evaluate the feasibility of the detective method. The simulation results validate the feasibility that the interface circuit can detect dual-axis acceleration separately and synchronously.
提出了一种大型微加工双轴加速度计的系统级模型。加速度计只有一个惯性质量,对称地悬挂在四对折叠弹性梁上。制作的加速度计尺寸为5.4 × 5.4 mm2。惯性质量的位移变化转化为主动梳和固定梳之间的差分电容变化。通常,输入加速度与x轴和y轴混合。在接口电路中采用分频法对混合信号进行分离和剔除。本文详细介绍了Simulink模型,并用该模型来评估检测方法的可行性。仿真结果验证了该接口电路分别同步检测双轴加速度的可行性。
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引用次数: 6
Flip-Chip Micro-Thermal Stress Simulation in Underfill Process 下充填过程倒装芯片微热应力模拟
W. Lou, X. Yu
MEMS package technology is playing an increasingly important part today. As one of important part of MEMS package technology, flip-chip technology is widely used in the assembly of high-performance that requires good functionality on substrate space. It has many advantages such as smaller size, increased functionality and lower cost. So it has been widely used in MEMS package. The thermal stress of flip-chip is analyzed by using the finite element analysis software in this paper. It simulates the thermal stress distributing of the flip-chip structure, which is caused by the high temperature during the underfill process. And by modifying all kinds of geometry parameters and material attributes, it analyses that how underfill CTE, solidifying temperature and bump size affect the thermal stress of the micro-structure. The results from this work would be very useful to optimize the technological parameter and improve the package properties.
MEMS封装技术在当今扮演着越来越重要的角色。倒装芯片技术作为MEMS封装技术的重要组成部分之一,广泛应用于要求在基板空间上具有良好功能的高性能组装。它具有体积更小、功能更强、成本更低等优点。因此在MEMS封装中得到了广泛的应用。本文利用有限元分析软件对倒装芯片的热应力进行了分析。模拟了下充填过程中高温对倒装结构热应力的影响。通过修改各种几何参数和材料属性,分析了下填CTE、凝固温度和凹凸尺寸对微观组织热应力的影响。研究结果对优化工艺参数、提高包装性能具有重要的指导意义。
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引用次数: 1
Immunogold Nanoparticle Combing Surface-Enhanced Raman Scattering Method for Protein A Detection 免疫金纳米粒子结合表面增强拉曼散射法检测蛋白A
Chi-Chang Lin, Jr-Tzai Chen, Yan-Fu Chen, T. Chang, Hsien-Chang Chang
An unique, sensitive, and highly specific immunoassay system using gold nanoparticles and surface-enhanced Raman spectroscopy (SERS) is described. To demonstrate the analytical capabilities of the new technique, Raman reporter (mercaptobenzoic, MBA) that is coimmobilized with biospeciflc anti-protein A on gold nanoparticles (AuNP). Anti-protein A-AuNP-MBA, which combing both electromagnetic field and chemical enhancement, was used to exploits the SERS-derived signal. A dynamic range of 2-3 orders of magnitude and 1-10 pg/mL of detection limitation of protein A were achieved. The results indicated this new technique could be used in clinical diagnostic applications with fast, high sensitivity and high-throughput screening of antibodies.
一个独特的,敏感的,高度特异性免疫分析系统使用金纳米粒子和表面增强拉曼光谱(SERS)被描述。为了证明新技术的分析能力,将拉曼报告基因(巯基苯甲酸,MBA)与生物特异性抗蛋白A共同固定在金纳米颗粒(AuNP)上。利用结合电磁场和化学增强的抗蛋白A-AuNP-MBA来利用sers衍生的信号。A蛋白的动态范围为2-3个数量级,检测限为1-10 pg/mL。结果表明,该方法具有快速、高灵敏度、高通量的抗体筛选方法,可用于临床诊断。
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引用次数: 0
Fabrication of a Complicated Heat Transfer Microchannel System for CPU Cooling Study 一种用于CPU冷却的复杂传热微通道系统的制作研究
H.T. Chen, C.W. Liu, S.G. Liu, C.S. Yang, C. Gau
Fabrication of a temperature sensor array and a heater in a complicated heat transfer microchannel system, on a glass substrate, is presented. In addition to the glass substrate, low thermal conductivity materials such as SU-8, PMMA plate are selected to form the micro channel wall to provide good thermal insulation. Both the titanium and the platinum are deposited sequentially on a glass plate and made into heater and sensors, respectively. Lift-off method is used to obtain the desired pattern for heater and sensors. The fabrication process is much simpler than those reported in literature. Design consideration and fabrication techniques involved in this processes is discussed. Finally, validation of the heaters and sensors fabricated and a measurement of the heat transfer coefficient distributions inside the micro channel is presented.
介绍了在玻璃基板上制造复杂传热微通道系统中的温度传感器阵列和加热器。除了玻璃基板外,还选择了低导热材料如SU-8、PMMA板等形成微通道壁,以提供良好的隔热效果。钛和铂依次沉积在玻璃板上,分别制成加热器和传感器。采用升离法获得加热器和传感器所需的模式。制作过程比文献报道的要简单得多。讨论了该工艺中涉及的设计考虑和制造技术。最后,对所制作的加热器和传感器进行了验证,并测量了微通道内的传热系数分布。
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引用次数: 1
Natural Frequencies of Single-Walled Carbon Nanotubes 单壁碳纳米管的固有频率
U. Lee, Hyukjin Oh, S. You
Fundamental natural frequencies of armchair single-walled carbon nanotubes (SWCNTs) are evaluated in this paper. As there is no universal agreement on the exact wall thickness of a SWCNT, some different wall thicknesses have been assumed by most of researchers to report a wide range of different elastic constants for a SWCNT. Thus, to compute the effective structural properties of SWCNTs needed for the evaluation of their fundamental natural frequencies, without needing to assume the controversial wall thickness, we adopt a new continuum modeling method developed in our previous study based on the energy equivalence principle.
本文对扶手型单壁碳纳米管(SWCNTs)的基本固有频率进行了评估。由于对单壁碳纳米管的确切壁厚没有统一的看法,大多数研究人员都假设了不同的壁厚,以报告不同的单壁碳纳米管弹性常数。因此,为了计算评估SWCNTs基本固有频率所需的有效结构特性,而不需要假设有争议的壁厚,我们采用了我们之前基于能量等效原理开发的新的连续介质建模方法。
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引用次数: 3
Application of Micro Sensors on Diagnosis of Micro Fuel Cells 微型传感器在微型燃料电池诊断中的应用
Chi-Yuan Lee, Shuo-Jen Lee, C. Hsieh
The fuel cell has the potential to become an indispensable source of electric power. However, some problems have not yet been resolved. Measuring the temperature and humidity inside the fuel cells is currently difficult. Accordingly, in this study, array micro sensors are fabricated within the fuel cell, in which the temperature and humidity distributions are measured. The substrate of the bipolar plate of the fuel cell was made of stainless steel (SS-304) and the wet etching was employed to fabricate the channel on the stainless steel substrate. Then microelectromechanical systems (MEMS) technology was used to fabricate the array micro temperature sensors and the micro humidity sensors on the rib of channel of stainless steel. The advantages of array micro temperature sensors are their small volume, their high accuracy, their short response time, the simplicity of their fabrication, their mass production and their ability to measure the temperature at a precise location more effectively than the traditional thermocouple. The micro humidity sensors are made from gold and titanium as down and up electrodes in the channel. The performance curves of the single cell operating at 41.54 degC and gas flow rates of H2/O2 at 200/200ml/min. The max power density of the bipolar without micro sensor is 142 mW/cm2 and the current density is 463 mA/cm2. The max power density of the bipolar with micro sensor is 56 mW/cm2.
燃料电池有可能成为一种不可或缺的电力来源。但是,有些问题还没有得到解决。测量燃料电池内部的温度和湿度目前是很困难的。因此,本研究在燃料电池内部制作阵列微传感器,测量其温度和湿度分布。燃料电池双极板的衬底为不锈钢(SS-304),采用湿法蚀刻在不锈钢衬底上制作通道。然后利用微机电系统(MEMS)技术在不锈钢通道肋上制作阵列微温度传感器和微湿度传感器。阵列微温度传感器的优点是体积小,精度高,响应时间短,制造简单,批量生产以及比传统热电偶更有效地在精确位置测量温度的能力。微湿度传感器由金和钛制成,作为通道中的上下电极。在41.54℃下,H2/O2气体流速为200/200ml/min时,单体电池的性能曲线。无微传感器双极极的最大功率密度为142 mW/cm2,电流密度为463 mA/cm2。微传感器双极极的最大功率密度为56 mW/cm2。
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引用次数: 1
A Novel Fabrication for Pressure Sensor with Polymer Material and Its Characteristic Testing 一种新型高分子材料压力传感器制造方法及其特性测试
H. Ko, C.W. Liu, C. Gau
In the current fabrication of pressure sensor, both the sensor cavity and the sensor diaphragm were made of SU-8 which can be readily spun coat on the substrate at desired thickness and patterned by lithography. The thickness of the diaphragm, and the height of the sensor cavities, allowing deformation of diaphragm, can be readily varied from few to hundreds of microns by spin coat different thickness of SU-8 layer. This allows fabrication of cavity with much greater heights and measurement of pressure with much wider range. However, the sensor material used for the pressure sensor is the polysilicon doped with a high concentration of boron, which can readily sense the deformation of a diaphragm. This has precluded the possibility of fabricating the cavities and diaphragm first - which is a low temperature process, and then depositing the polysilicon sensor on the above - which is a high temperature process. Fabrication strategy has to be reversed, i.e., starts with the high temperature process of depositing the doped polysilicon layer and then the low temperature process.
在目前的压力传感器制造中,传感器腔和传感器膜片都是由SU-8制成的,SU-8可以很容易地以所需的厚度涂覆在基板上,并通过光刻进行图案化。通过自旋涂覆不同厚度的SU-8层,膜片的厚度和允许膜片变形的传感器腔的高度可以很容易地从几微米到几百微米变化。这允许制造更高高度的腔体和更宽范围的压力测量。然而,用于压力传感器的传感器材料是掺杂高浓度硼的多晶硅,它可以很容易地感知隔膜的变形。这就排除了首先制造空腔和隔膜的可能性——这是一个低温过程,然后在上面沉积多晶硅传感器——这是一个高温过程。制造策略必须反转,即从沉积掺杂多晶硅层的高温工艺开始,然后再进行低温工艺。
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引用次数: 2
The application of Iron Oxide magnetic nanoparticles to improve the binding efficiency of the IgG and Thiol SAMs 应用氧化铁磁性纳米颗粒提高IgG和硫醇类SAMs的结合效率
D. Yao, Chun-Yi Lin, Fang-Gang Tseng
Superparamagnetic nanoparticles have been fabricated successfully, which are composed of Fe3O4 by using wet chemical co-precipitate method. The nanoparticles were functionalized on the surface by conjugated with the abti-Rabbit IgG. In the recently research, we try to use this system to approach the work which is to increase the reaction efficiency between antibodies and antigens by applying magnetic fields to alternate the binding samples in solution. The applied magnetic fields are produced by electro-magnets with AC or DC input. In the preliminary experiment, the antibodies were reacted with the carboxyl group Thiol SAMs that were modified on the glass chip with gold film. The surface plasma resonance (SPR) was used to detect the binding number of antibodies on the chip. The binding efficiency could be further calculated. The results showed the binding efficiency could be improved by using superparamagnetic nanoparticles with applying magnetic fields.
采用湿化学共沉淀法成功制备了由Fe3O4组成的超顺磁性纳米颗粒。纳米颗粒通过与抗兔IgG偶联在表面实现功能化。在最近的研究中,我们尝试使用该系统来研究通过施加磁场交替结合样品来提高抗体和抗原之间的反应效率的工作。外加磁场由交流或直流输入的电磁铁产生。在初步实验中,抗体与羧基硫醇SAMs反应,并在玻璃芯片上用金膜修饰。采用表面等离子体共振(SPR)检测抗体在芯片上的结合数。结合效率可以进一步计算。结果表明,在外加磁场的作用下,超顺磁性纳米颗粒可以提高其结合效率。
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引用次数: 1
The Study of Flexible Plate Wave Device for Micro Pumping System 微泵系统柔性板波装置的研究
M. Tsai, T. Leu
This paper investigates on micro pumping system, flow field generated by an traveling wave boundary layer, which model is developed for flexural plate wave (FPW) device numerically. In the study, the steady state solution of a FPW pump is most concerned. The velocity profiles and net flow rate for different parameters including frequency, channel height, and wave length are investigated. In this device, it is found that flow field remains periodic. The time averaged velocity profiles over one period become a parabolic velocity profile when the channel height is less than 100 mum. When a channel height is higher than 200jim, the time averaged velocity profiles deviate from parabolic velocity profile to a wall-jet type velocity profile. This finding is different from previous study. The acoustic pressure can influence as high as 100 Jim channel height. The pressure wave confinement effect in a microchannel with height less than 100 Jim is noticed. This research also finds that the flow rate of FPW pump can be controlled by the frequency.
本文研究了微泵系统中行波边界层产生的流场,并建立了弯曲板波装置的流场数值模型。在研究中,最受关注的是FPW泵的稳态解。研究了不同频率、通道高度和波长参数下的流速分布和净流量。在该装置中,发现流场保持周期性。当通道高度小于100 μ m时,一个周期内的时间平均速度曲线变为抛物线速度曲线。当通道高度大于200jim时,时间平均速度剖面由抛物型速度剖面向壁面射流型速度剖面偏移。这一发现与之前的研究不同。声压可以影响高达100 Jim的通道高度。研究了高度小于100 Jim的微通道中压力波的约束效应。研究还发现,FPW泵的流量可以通过频率控制。
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引用次数: 5
期刊
2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems
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