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Comparative evaluation on the effect of different cavity disinfectant nano gels; Chlorohexidine, Propolis, Liquorice versus Diode Laser in terms of composite microleakage (comparative in vitro study). 不同空腔消毒纳米凝胶效果的比较评价氯己定、蜂胶、甘草与二极管激光复合微泄漏的比较研究。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-11-11 DOI: 10.1038/s41405-023-00176-2
Maryam Mohamed ElMansy, Silvia Sabry Tawfik Tadros, Reham Sayed Saleh, Rehab Abdelmonem, Hala El Menoufy, Naglaa Shawky

Introduction: The application of different cavity disinfectants is an essential step that eliminates bacteria after cavity preparation. However, some of these materials may affect restoration sealing ability.

Aim: This study aimed to assess the degree of microleakage at the tooth restoration interface after using different nano prepared cavity disinfectants versus Diode Laser.

Materials and methods: Three disinfectants were prepared on the nanoscale; Propolis, Liquorice and Chlorhexidine. A total of 40 extracted premolars with standard class V cavities were prepared on the facial surface. Teeth were divided into five groups according to the applied cavity disinfection protocol; no treatment, Chloehexidine, Propolis, Liquorice, and Diode Laser. After application of composite resin restoration, all teeth were subjected to thermocycling, afterwords the degree of microleakage was measured in micrometers. Data were analyzed by one-way analysis of variance (ANOVA) test, followed by Bonferroni's and Tukey's post hoc test.

Results: The highest mean microlekage value was recorded in no treatment group, followed by Liquorice, Propolis. While Diode Laser group showed the lowest degree of microleakage.

Conclusion: Diode Laser cavity disinfectant has no negative effect on the restoration sealing ability. Nano prepared Propolis showed comparative results to nanoChloehexidine as both had low degree of microleakage.

应用不同的口腔消毒剂是口腔准备后消除细菌的必要步骤。然而,这些材料中的一些可能会影响修复的密封能力。目的:比较不同纳米口腔消毒剂与二极管激光对牙体修复界面微渗漏的影响程度。材料与方法:制备了三种纳米级消毒剂;蜂胶,甘草和氯己定。拔除的前磨牙共40颗,均为标准的V类空腔。按照应用口腔消毒方案将牙齿分为5组;无处理,氯己定,蜂胶,甘草,二极管激光。应用复合树脂修复后,所有牙齿进行热循环,然后以微米为单位测量微泄漏程度。数据分析采用单因素方差分析(ANOVA)检验,随后采用Bonferroni’s和Tukey’s事后检验。结果:未给药组平均微漏值最高,甘草、蜂胶次之。而二极管激光组微漏程度最低。结论:二极管激光腔消毒剂对修复密封能力无负面影响。纳米蜂胶与纳米氯己定的微泄漏程度均较低。
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引用次数: 0
Efficacy and safety of using antibiotics to prevent post-operative complications in oral implant treatment: evidence-based review. 在口腔种植体治疗中使用抗生素预防术后并发症的有效性和安全性:循证综述。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-10-31 DOI: 10.1038/s41405-023-00174-4
Javed Ikram, Rawand Shado, Ines Novo Pereira, David Madruga, Haidar Hassan

Aims: To identify and critically appraise available evidence on the efficacy and safety of antibiotics in preventing complications following oral implant placement treatment.

Methods: An electronic search was performed using PubMed, Ovid MEDLINE and Cochrane Library databases up to July/21 for the purpose of answering the research question: In[healthy adults treated with dental implants]the use of[different antibiotics before or immediately after treatment]in comparison to[treatment without antibiotics]is safe and effective in terms of[infection, pain, swelling, wound dehiscence, soft tissue healing, early/late implant failure]? Following the Best Evidence Topic methodology, the included studies were categorised based on the Oxford Centre for Evidence-Based Medicine (OCEBM) ratings. The critical appraisal skills programme CASP checklist was used for the methodological analysis. The risk of bias assessment was performed according to the Cochrane Methodology for Systematic Reviews of Interventions.

Results: 26 of the 245 initially identified articles met our inclusion criteria for analysis after applying rigorous filters. The included human studies demonstrated significant methodological heterogeneity, precluding meta-analysis. These studies spanned evidence levels II to IV, as per OCEBM 2011 classifications, with the United States contributing the most studies (19.2%, n = 5), all at level III. The United Kingdom and Spain followed with three studies each (11.5% each), two from the UK and one from Spain classified at level II. Most studies had less than 1 year of follow-up (21%). Our analysis included 26 studies, with 38 antibiotic patient groups totalling 7459 patients. Amoxicillin was the predominant antibiotic, with various dosage regimens. Complications were observed in studies across different amoxicillin regimens at a cumulative incidence of 5%.

Conclusion: The evidence on antibiotics to prevent implant failure presents uncertain and heterogeneous findings. High-risk bias and underpowered studies were prevalent. Future research should prioritise multicentre, double-blinded RCTs with larger samples and longer follow-ups. Structured methodologies, antibiotic stewardship, and adherence to guidelines are needed. Amoxicillin (2 g) was commonly prescribed, but guidelines recommend 3 g, which results in relatively low complications yet there is limited evidence to support it. Clindamycin was favoured for penicillin allergies, but caution is advised due to potential implant failure risk. Consistent use of antiseptic mouthwash was observed. Future research should explore alternatives to antibiotics and antibiotic stewardship. Establishing a well-funded research consortium could yield conclusive results for clinical practice.

目的:确定并严格评估抗生素在预防口腔植入治疗后并发症方面的有效性和安全性的现有证据。方法:使用PubMed进行电子检索,Ovid MEDLINE和Cochrane Library数据库截至2021年7月,目的是回答研究问题:在[接受牙科植入物治疗的健康成年人]中,与[不使用抗生素的治疗]相比,在治疗前或治疗后立即使用[不同的抗生素]是安全有效的[感染、疼痛、肿胀、伤口裂开、软组织愈合、早期/晚期植入失败]?根据最佳证据主题方法,纳入的研究根据牛津循证医学中心(OCEBM)的评级进行分类。关键评估技能方案CASP检查表用于方法分析。根据Cochrane干预措施系统评价方法进行偏倚风险评估。结果:245篇最初确定的文章中,有26篇在应用严格的过滤器后符合我们的纳入标准进行分析。纳入的人类研究显示出显著的方法异质性,排除了荟萃分析。根据OCEBM 2011的分类,这些研究涵盖了证据级别II至IV,其中美国贡献了最多的研究(19.2%,n = 5) ,均为III级。随后,英国和西班牙各进行了三项研究(各占11.5%),其中两项来自英国,一项来自西班牙,均为II级。大多数研究的随访时间不到1年(21%)。我们的分析包括26项研究,38个抗生素患者组共7459名患者。阿莫西林是主要的抗生素,有不同的剂量方案。在不同阿莫西林方案的研究中观察到并发症的累积发生率为5%。结论:抗生素预防植入失败的证据存在不确定性和异质性。高风险偏见和研究不足普遍存在。未来的研究应优先考虑多中心、双盲随机对照试验,具有更大的样本和更长的随访时间。需要结构化的方法、抗生素管理和遵守指南。阿莫西林(2 g) 通常是处方药,但指南建议3 g、 这导致相对较低的并发症,但支持它的证据有限。克林霉素对青霉素过敏是有利的,但由于潜在的植入失败风险,建议谨慎。观察到持续使用防腐漱口水。未来的研究应该探索抗生素的替代品和抗生素管理。建立一个资金充足的研究联盟可以为临床实践产生决定性的结果。
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引用次数: 0
Correction: Effect of eucalyptus oil on Streptococcus mutans and Enterococcus faecalis growth. 更正:桉树油对变形链球菌和粪肠球菌生长的影响。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-10-16 DOI: 10.1038/s41405-023-00173-5
Abdulrahman A Balhaddad, Rasha N AlSheikh
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引用次数: 0
A descriptive study of percutaneous injuries in National Healthcare Group POLYCLINICS dental clinics in Singapore from 2014 to 2020. 2014年至2020年新加坡国家医疗集团POLYCLINICS牙科诊所经皮损伤的描述性研究。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-10-16 DOI: 10.1038/s41405-023-00171-7
Vivian Yung Yee Wong, Priscilla Jang Shing Chao, Sabrina Poay Sian Lee, Eng Sing Lee, Lily Ren Lee Lang, Holy Jr Koh, Kenneth Meng Tze Low

Introduction: All dental staff face risk of percutaneous injuries (PCI)s. Blood-borne diseases may be transmitted to staff via contaminated sharp instruments. Hence there are significant impacts on staff when PCIs occur. Though a PCI is an occupational hazard, it is preventable.

Aim: This study aims to identify factors associated with PCIs among dental staff by evaluating the circumstances and staff designations involved.

Methods: PCIs were reported through an electronic incident reporting system from 2014 to 2020. Reports involved their nature and extent. Statistical analysis was carried out to find associations between factors such as injury site, type of instrument and staff designation.

Results: A total of 63 PCIs were included in this study. The type of instrument was found to be significantly associated with staff designation (p = 0.04, p < 0.05) with significantly more dental burs causing injury in dentists and more injuries caused by 'other instruments' in health attendants (p = 0.0083). Majority of PCIs occurred in dentists, then dental assistants and health attendants. Staff designation was significantly associated with the instance where PCIs occurred (p < 0.001). Dentists and dental assistants were more likely to sustain injuries during a dental procedure than before procedure and after procedure (p = 0.0167). The mean incidence of PCIs among our dentists was 15.6/100.

Conclusions: All dental staff are at risk of PCIs however dentists sustain the highest number of PCIs. Needles, dental burs and metal matrices are the top three instruments. Targeted interventions might help prevent/reduce PCIs.

引言:所有牙科工作人员都面临经皮穿刺损伤(PCI)的风险。血液传播的疾病可能通过受污染的尖锐器具传播给工作人员。因此,当PCI发生时,会对员工产生重大影响。尽管PCI是一种职业危害,但它是可以预防的。目的:本研究旨在通过评估相关情况和工作人员的指定,确定牙科工作人员PCI的相关因素。方法:2014年至2020年,通过电子事故报告系统报告PCI。报告涉及其性质和范围。进行了统计分析,以找出受伤地点、仪器类型和工作人员指定等因素之间的关联。结果:本研究共纳入63例PCI。研究发现,仪器类型与工作人员的任命显著相关(p = 0.04,p 结论:所有牙科工作人员都有PCI的风险,但牙医的PCI数量最多。针头、牙套和金属基质是排名前三的器械。有针对性的干预措施可能有助于预防/减少PCI。
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引用次数: 0
Effect of various types of milk on salivary pH among children: a pilot randomized controlled crossover trial. 不同类型的牛奶对儿童唾液pH值的影响:一项随机对照交叉试验。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-09-13 DOI: 10.1038/s41405-023-00170-8
Rouaa Zamzam, Mawia Karkoutly, Nada Bshara

Objective: This study aimed to evaluate salivary pH changes after consuming three types of milk in children aged 3-5 years. The null hypothesis was that no statistically significant difference would be noted in the salivary pH between high-protein, full-fat, and sweetened milk groups at different time points.

Materials and methods: This was a double-blind, pilot randomized controlled crossover trial. 30 Children have undergone three experimental sessions with a 1-week washout period. Each child was given 250 mL of one of the following types of milk: high-protein, full-fat, or sweetened milk. The salivary pH was measured at the baseline (t0) after 5 (t1), 10 (t2), 15 (t3), 30 (t4), and 60 (t5) minutes of milk consumption, using a pH saliva indicator strip.

Results: There is a sharp drop in salivary pH after 5 min of sweetened (P < 0.05) and full-fat milk consumption (p < 0.05). However, the initial drop in the salivary pH was found to remain above the critical level. For the high-protein milk group, salivary pH decreased slightly after 5 min but was similar to that at the baseline (p = 0.573). In the high-protein milk group (p < 0.05), the salivary pH was slightly greater than the baseline value at t5.

Conclusions: The study shows an initial suggestion that milk is a non-cariogenic beverage, even when sugar is added. Furthermore, high-protein milk has a protective effect from dental caries.

目的:本研究旨在评价3-5岁儿童饮用三种牛奶后唾液pH值的变化。原假设是,在不同的时间点,高蛋白、全脂和加糖牛奶组的唾液pH值没有统计学上的显著差异。材料和方法:这是一项双盲、先导、随机对照交叉试验。30名儿童进行了三次实验,洗脱期为1周。给每个孩子250毫升的牛奶:高蛋白、全脂或加糖牛奶。使用唾液pH值指示条,在牛奶消耗5 (t1)、10 (t2)、15 (t3)、30 (t4)和60 (t5)分钟后,在基线(t0)测量唾液pH值。结果:加糖5min后,大鼠唾液pH值急剧下降。结论:这项研究初步表明,即使添加了糖,牛奶也是一种不会导致龋齿的饮料。此外,高蛋白牛奶对龋齿有保护作用。
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引用次数: 0
Correction: The accuracy of virtual setup in simulating treatment outcomes in orthodontic practice: a systematic review. 纠正:在正畸实践中虚拟设置模拟治疗结果的准确性:一个系统的回顾。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-09-12 DOI: 10.1038/s41405-023-00169-1
Benja Sereewisai, Rochaya Chintavalakorn, Peerapong Santiwong, Theerasak Nakornnoi, Siew Peng Neoh, Kawin Sipiyaruk
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引用次数: 0
Cross-cultural translation and modification of the revised oral assessment guide for oral health assessment by non-dentists. 非牙医口腔健康评估口腔评估指南修订版的跨文化翻译与修改
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-09-12 DOI: 10.1038/s41405-023-00168-2
Nareudee Limpuangthip, Orapin Komin, Jumphitta Chaichaowarat, Patthamaporn Phumkor

Objectives: This study aimed to conduct a cross-cultural translation of the revised oral assessment guide (ROAG) into Thai language and to modify the tool to increase its validity and reliability.

Materials and methods: The present study was a cross-sectional design conducted in dental and hospitalized patients, and community-dwelling people. The original English-version of the ROAG was translated into Thai, which was evaluated for validity and reliability. The tool was then revised to develop the modified ROAG for non-dentist (ndROAG) comprising 9 oral assessment categories with a three-level response; healthy, mild, and severe alteration. The criterion validity of the ndROAG was tested in 82 adult and older participants, and 46 non-dentists comprising dental assistants, dental hygienists, community health volunteers, and nurses, using a calibrated dentist as the reference standard. The ndROAG was translated back into an English version. The criterion validity was evaluated using weighted Kappa (Kw) and intraclass correlation coefficient (ICC). Internal consistency was determined using Cronbach alpha. The three-level response was dichotomized into healthy and changed to determine the sensitivity and specificity.

Results: The Kw values, ICC, and Cronbach alpha values of the ndROAG were higher than those of the pre-test ROAG. The sensitivity of the ndROAG in identifying the healthy and changed state ranged from 57.1 to 100.0% with the lowest value in the saliva category, whereas the specificity ranged from 90.9-100.0%.

Conclusion: The original ROAG was translated and revised into the ndROAG with improved validity and reliability. The ndROAG can be used by non-dentists to assess the oral health of adult and older individuals to detect oral changes, which includes self-care instructions and patient referral guidance.

目的:本研究旨在对修订后的口头评估指南(ROAG)进行泰国语的跨文化翻译,并对该工具进行修改以提高其效度和信度。材料和方法:本研究采用横断面设计,在牙科和住院患者以及社区居民中进行。将ROAG的原始英文版本翻译成泰语,并对其进行效度和信度评估。然后对该工具进行修订,以开发非牙医的改进ROAG (ndROAG),包括9个口腔评估类别,三个级别的反应;健康的,轻微的,严重的变化。采用一名校准过的牙医作为参考标准,对82名成人和老年参与者以及46名非牙医(包括牙科助理、牙科保健员、社区卫生志愿者和护士)进行了标准效度测试。ndROAG被翻译回英文版。采用加权Kappa (Kw)和类内相关系数(ICC)评价标准效度。内部一致性采用Cronbach alpha测定。将三个水平的反应分为健康和改变,以确定敏感性和特异性。结果:ndROAG的Kw值、ICC值和Cronbach alpha值均高于前测ROAG。ndROAG对健康和改变状态的敏感性为57.1 ~ 100.0%,在唾液类别中最低,而特异性为90.9 ~ 100.0%。结论:将原ROAG翻译修改为ndROAG,提高了信度和效度。非牙医可以使用ndROAG来评估成人和老年人的口腔健康,以发现口腔变化,其中包括自我保健指导和患者转诊指导。
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引用次数: 0
Calcium phosphate ceramic as a model for enamel substitute material in dental applications. 磷酸钙陶瓷作为牙釉质替代材料的模型。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-09-03 DOI: 10.1038/s41405-023-00152-w
Phakvalunch Rujiraprasert, Sarat Suriyasangpetch, Anucharte Srijunbarl, Thawanrat Singthong, Chalermkwan Makornpan, Katanchalee Nampuksa, Thanaphum Osathanon, Dusit Nantanapiboon, Naruporn Monmaturapoj

Objective: This study aimed to develop enamel substitute material using a mechanochemical technique.

Materials and methods: Hydroxyapatite was synthesized with and without tricalcium phosphate under uniaxial pressing of 10 and 17 MPa (HA10, HA17, BCP10, and BCP17), followed by sintering at 1250 °C for 2 h. Human enamel and dentin blocks were used as control groups. The mechanical properties were determined by compressive strength test and Vickers microhardness. The data were analyzed with one-way ANOVA and LSD post-hoc test (α = 0.05). The phase formation and morphology of the specimens were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM).

Results: HA17 and HA10 had compressive strength values comparable to enamel and dentin, respectively (p > 0.05). The microhardness of all synthesized groups was significantly higher than that of tooth structures (p < 0.05). From the XRD graphs, only the hydroxyapatite peak was observed in the control and HA groups. SEM images showed homogeneous hydroxyapatite grains in all groups, while the BCP groups contained higher porosities.

Conclusions: Both HA10 and HA17 are suitable for use as the inorganic part of dentin and enamel substitutes.

目的:利用机械化学技术开发牙釉质替代材料。材料和方法:分别在10和17 MPa (HA10、HA17、BCP10和BCP17)单轴压力下合成羟基磷灰石,1250℃烧结2 h。人牙釉质和牙本质块作为对照组。通过抗压强度试验和维氏显微硬度测定了材料的力学性能。采用单因素方差分析和LSD事后检验(α = 0.05)。采用x射线衍射仪(XRD)和扫描电镜(SEM)对试样的相形成和形貌进行了表征。结果:HA17和HA10抗压强度值分别与牙本质和牙釉质相当(p > 0.05)。所有合成基团的显微硬度均显著高于牙结构(p)。结论:HA10和HA17均适合作为牙本质和牙釉质替代品的无机部分。
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引用次数: 0
The accuracy of virtual setup in simulating treatment outcomes in orthodontic practice: a systematic review. 虚拟设置在正畸实践中模拟治疗结果的准确性:一项系统综述。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-08-28 DOI: 10.1038/s41405-023-00167-3
Benja Sereewisai, Rochaya Chintavalakorn, Peerapong Santiwong, Theerasak Nakornnoi, Siew Peng Neoh, Kawin Sipiyaruk

Objectives: To evaluate the accuracy of virtual orthodontic setup in simulating treatment outcomes and to determine whether virtual setup should be used in orthodontic practice and education.

Materials and methods: A systematic search was performed in five electronic databases: PubMed, Scopus, Embase, ProQuest Dissertations & Theses Global, and Google Scholar from January 2000 to November 2022 to identify all potentially relevant evidence. The reference lists of identified articles were also screened for relevant literature. The last search was conducted on 30 November 2022.

Results: This systematic review included twenty-one articles, where all of them were assessed as moderate risk of bias. The extracted data were categorized into three groups, which were: (1) Virtual setup and manual setup; (2) Virtual setup and actual outcomes in clear aligner treatment; (3) Virtual setup and actual outcomes in fixed appliance treatment. There appeared to be statistically significant differences between virtual setups and actual treatment outcomes, however the discrepancies were clinically acceptable.

Conclusion: This systematic review supports the use of orthodontic virtual setups, and therefore they should be implemented in orthodontic practice and education with clinically acceptable accuracy. However, high-quality research should be required to confirm the accuracy of virtual setups in simulating treatment outcomes.

目的:评估虚拟正畸设置在模拟治疗结果方面的准确性,并确定虚拟设置是否应用于正畸实践和教育。材料和方法:2000年1月至2022年11月,在PubMed、Scopus、Embase、ProQuest Dissertations&Theses Global和Google Scholar五个电子数据库中进行了系统搜索,以确定所有潜在的相关证据。已鉴定文章的参考文献列表也进行了相关文献筛选。最后一次搜索于2022年11月30日进行。结果:这项系统综述包括21篇文章,所有文章都被评估为中度偏倚风险。将提取的数据分为三组:(1)虚拟设置和手动设置;(2) 清晰对准器治疗的虚拟设置和实际结果;(3) 固定矫治器治疗中的虚拟设置和实际结果。虚拟设置和实际治疗结果之间似乎存在统计学上的显著差异,但这些差异在临床上是可以接受的。结论:本系统综述支持使用正畸虚拟设置,因此应在正畸实践和教育中以临床可接受的准确性实施。然而,应该需要高质量的研究来确认虚拟设置在模拟治疗结果方面的准确性。
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引用次数: 1
Evaluation of a digital oral health intervention (Know Your OQ™) to enhance knowledge, attitudes and practices related to oral health. 评估数字口腔健康干预(Know Your OQ™),以提高与口腔健康相关的知识、态度和做法。
IF 3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-08-26 DOI: 10.1038/s41405-023-00166-4
George Kitsaras, Juliana Gomez, Richard Hogan, Maria Ryan

Objective/aim: Optimal oral health behaviours are crucial to avoid preventable dental diseases and maintain good oral health. This research aimed to evaluate the impact of a digital oral health intervention (Know Your OQ™) in changing knowledge, attitudes and practices related to oral health.

Materials & methods: Two studies were conducted with a total of 296 healthy adults. Demographic data as well as knowledge, attitudes, and practices (KAPs) related to oral health were collected before and after completion of the Know Your OQ™ intervention. The KAPs questionnaire included 19 multiple choice questions. Comprehension and feedback were also collected.

Results: In total, 134 (45%) male and 162 (55%) female participants completed the two studies. Across both studies, 5 out of 7 knowledge questions and 2 out of 5 attitude questions showed significant changes pre/post-intervention with participants increasing their knowledge and improving their attitudes towards oral health. Only 1 practice changed in the first study, however, in the second study, 4 out of 7 practice questions showed significant changes pre/post-intervention. Comprehensibility was high across both studies with overall, positive feedback on the intervention.

Conclusion: A digital oral health intervention was successful in increasing knowledge, changing attitudes and self-reported practices with regards to oral health in a diverse sample of the US population.

目标/目的:良好的口腔卫生行为对避免可预防的口腔疾病和保持良好的口腔健康至关重要。本研究旨在评估数字口腔健康干预(Know Your OQ™)在改变与口腔健康相关的知识、态度和实践方面的影响。材料与方法:两项研究共纳入296名健康成人。在完成Know Your OQ™干预之前和之后,收集了与口腔健康相关的人口统计数据以及知识、态度和实践(KAPs)。KAPs问卷包括19道选择题。并收集理解和反馈。结果:共有134名(45%)男性和162名(55%)女性参与者完成了这两项研究。在两项研究中,7个知识问题中的5个和5个态度问题中的2个在干预前后显示出显著的变化,参与者对口腔健康的知识和态度都有所增加。在第一项研究中只有1项练习发生了变化,而在第二项研究中,7个练习问题中有4个在干预前后出现了显著变化。两项研究的可理解性都很高,对干预的总体反馈是积极的。结论:数字口腔健康干预在美国不同人群中成功地提高了对口腔健康的认识,改变了态度和自我报告的做法。
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引用次数: 0
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