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Do CAD-CAM fibre posts exhibit higher bond strength and fracture resistance than other types of posts? systematic review with network meta-analysis of in-vitro studies. CAD-CAM 纤维支柱是否比其他类型的支柱具有更高的粘接强度和抗断裂性?
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-17 DOI: 10.1038/s41405-025-00315-x
Mohammed Maher Ghanem, Xin Yi Leong, Sajesh K Veettil, Anas Al Jada, Musab Saeed, Rohit Kunnath Menon

Introduction: Pre-fabricated fibre posts facilitate post-endodontic restoration of endodontically treated teeth with insufficient coronal tooth structure. Recent advancements in digital dentistry have led to the introduction of custom-made fibre posts fabricated with computer-aided design-computer-aided manufactured (CAD-CAM) technology. However, evidence on the comparative performance of the different post-types is lacking. This systematic review with network meta-analysis aimed to analyse the current evidence on in-vitro studies comparing bond strength, catastrophic failures, fracture resistance, and cement film thickness between CAD-CAM fibre posts and other post types, including pre-fabricated fibre and custom-made cast-metal posts.

Materials and methods: A systematic search was conducted in PubMed, Scopus, and the Cochrane Central Register of Controlled Studies for in-vitro studies from inception until December 2023 (PROSPERO: CRD42024501614). Network meta-analysis and pairwise meta-analysis were performed. The ranking was performed using the surface area under the cumulative ranking (SUCRA) guidelines.

Results: Seven hundred forty-one articles were identified, of which 80 duplicates were removed, and 585 were excluded by screening the titles and abstracts. A total of 76 articles were assessed by full-text reading, and 16 were included in the quantitative synthesis. CAD-CAM fibre posts (SMD = 1.09 [95% CI: 0.01, 2.17]) P = 0.04 demonstrated higher bond strength when compared to pre-fabricated posts. CAD-CAM fibre posts (RR = 0.39 [95% CI: 0.23, 0.69]) P < 0.05 demonstrated a lower risk for catastrophic failures when compared to pre-fabricated fibre posts.

Conclusions: In-vitro studies demonstrated that CAD-CAM fibre posts demonstrated higher bond strength, lower catastrophic failure rates, and similar fracture resistance compared to pre-fabricated and cast metal posts. The data on bond strength and catastrophic failures of CAD-CAM fibre posts must be validated clinically by high-quality, randomised, controlled clinical trials.

简介:预制纤维桩有利于冠状牙结构不足的牙根管治疗后的牙根修复。数字牙科的最新进展导致了采用计算机辅助设计-计算机辅助制造(CAD-CAM)技术制造的定制纤维桩的引入。但是,缺乏关于不同员额类型的比较业绩的证据。本系统综述采用网络荟萃分析,旨在分析目前体外研究的证据,比较CAD-CAM纤维桩与其他类型的桩(包括预制纤维桩和定制铸造金属桩)之间的粘结强度、灾难性破坏、抗断裂能力和水泥膜厚度。材料和方法:系统检索PubMed, Scopus和Cochrane Central Register of Controlled Studies,从成立到2023年12月进行体外研究(PROSPERO: CRD42024501614)。进行网络元分析和两两元分析。在累积排名(SUCRA)指南下,使用表面积进行排名。结果:通过筛选题目和摘要,共筛选到741篇文献,剔除重复80篇,排除585篇。全文阅读共评估了76篇文章,其中16篇纳入定量综合。与预制桩相比,CAD-CAM纤维桩(SMD = 1.09 [95% CI: 0.01, 2.17]) P = 0.04显示出更高的粘结强度。结论:体外研究表明,与预制和铸造金属桩相比,CAD-CAM纤维桩具有更高的粘结强度、更低的灾难性故故率和相似的抗断裂能力。CAD-CAM纤维桩的粘结强度和灾难性失效数据必须通过高质量的随机对照临床试验进行临床验证。
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引用次数: 0
Comparative evaluation on the masking ability of different tooth colored restoration over blackish discoloration caused by 38% silver diamine fluoride: an in -vitro study. 不同牙色修复体对38%氟化二胺银致发黑的掩蔽能力的体外比较评价
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-17 DOI: 10.1038/s41405-025-00318-8
Prajval Mahajan, Anupama Nayak P, Srikant Natarajan, Karuna Yarmunje Mahabala, Kiran N Baliga, Ashwin Rao, Charisma Thimmaiah

Background: The application of Silver diamine fluoride is an effective approach in controlling dental caries. But the black discoloration caused by its application is unaesthetic and is of greater concern to the parents.

Aim: To assess the potential color masking ability of tooth colored restorative material over discoloration caused by 38% SDF using a UV‒VIS-NIR spectrophotometer.

Material and methods: 20 extracted teeth were taken and randomly divided into 4 groups: Group A: 38% SDF + GIC; Group B: 38% SDF + RMGIC; Group C: 38% SDF+ Composite; Group D: 38% SDF+ Cention N. Two readings were recorded, one on application of 38% SDF and second after application of test materials using a UV‒VIS-NIR spectrophotometer.

Result: The intragroup comparison for color masking ability (ΔE) for all four restorative materials revealed no statistically significant differences, with a test value of 1.168 and a p value of 0.353, and the highest mean was observed in Group A, i.e., 38% SDF + GIC (9.171966) Significant differences in color were observed, with more shifts toward yellow in group A (2.488 ± 2.957) and group D (1.686 ± 0.559) and more shifts toward green in groups B (-0.088 ± 0.34) and C (-0.062 ± 0.5). The mean lightness was greatest for Group C, i.e., the composite group (86.396 ± 3.741), and least for Group A, i.e., the GIC group (76.664 ± 8.213).

Conclusion: All 4 restorative materials were equally effective in terms of color masking over 38% SDF discoloration.

背景:氟化二胺银是防治龋病的有效方法。但由于其使用造成的黑色变色是不美观的,是家长更关心的问题。目的:用紫外-可见-近红外分光光度计评价牙色修复材料对38% SDF引起的变色的潜在遮盖能力。材料与方法:取拔牙20颗,随机分为4组:A组:38% SDF + GIC;B组:38% SDF + RMGIC;C组:38% SDF+复合;使用UV-VIS-NIR分光光度计记录两次读数,一次是在应用38% SDF时,第二次是在应用测试材料后。结果:社会团体内部的对比颜色的掩蔽能力(ΔE)为所有四个修复材料并没有发现显著差异,测试值为1.168,p值为0.353,最高的意思是在a组观察,也就是说,38%自卫队+ GIC(9.171966)显著差异观察颜色,更多的转向黄色在a组(2.488±2.957)和D组(1.686±0.559)和更多的转向绿色在B组(-0.088±0.34)和C(-0.062±0.5)。C组(即复合组)的平均亮度最大(86.396±3.741),A组(即GIC组)的平均亮度最小(76.664±8.213)。结论:4种修复材料对38% SDF变色的遮盖效果相同。
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引用次数: 0
Drug-associated gingival disorders: a retrospective pharmacovigilance assessment using disproportionality analysis. 药物相关牙龈疾病:使用歧化分析的回顾性药物警戒评估。
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-11 DOI: 10.1038/s41405-024-00291-8
Kannan Sridharan, Gowri Sivaramakrishnan

Background: Drug-associated gingival disorders can negatively impact on oral health. This study aimed to utilize the United States Food and Drug Administration Adverse Event Reporting System (USFDA AERS) to comprehensively assess the associations between medications and specific gingival disorders.

Methods: Data were extracted from the USFDA AERS from 2004-2024 using Preferred Terms for eight gingival disorders. Reports were deduplicated and disproportionality analysis was conducted using frequentist and Bayesian approaches to detect potential signals. Volcano plots were generated for each gum disorder to identify the drugs with the strongest signals based on the statistical significance and magnitude of association.

Results: A total of 11,465 reports were included. Several anti-osteoporotic drugs, anti-thrombotics, calcium channel blockers and immunosuppressants showed significant associations with multiple gingival disorders. Phenytoin was linked to hypertrophy and bleeding. Stomatological preparations were associated with discoloration and bleeding. Emergent signals were identified with finasteride, COVID-19 vaccine, and levothyroxine with gum disorders.

Conclusion: This study highlights the need for increased awareness of oral side effects amongst healthcare providers. Future research should explore the mechanisms of drug-induced gingival disorders and develop interdisciplinary management strategies to enhance oral health in patients on long-term medications.

背景:药物相关性牙龈疾病会对口腔健康产生负面影响。本研究旨在利用美国食品和药物管理局不良事件报告系统(USFDA AERS)来全面评估药物与特定牙龈疾病之间的关系。方法:从2004-2024年USFDA AERS中提取8种牙龈疾病的首选术语数据。报告被重复删除,歧化分析使用频率和贝叶斯方法来检测潜在的信号。为每种牙龈疾病生成火山图,根据统计显著性和关联程度来识别具有最强信号的药物。结果:共纳入11465份报告。几种抗骨质疏松药物、抗血栓药、钙通道阻滞剂和免疫抑制剂与多种牙龈疾病有显著相关性。苯妥英与肥厚和出血有关。口腔制剂与变色和出血有关。非那雄胺、COVID-19疫苗和左旋甲状腺素与牙龈疾病一起确定了紧急信号。结论:本研究强调需要提高卫生保健提供者对口服副作用的认识。未来的研究应探索药物性牙龈疾病的机制,并制定跨学科的管理策略,以提高长期用药患者的口腔健康。
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引用次数: 0
In vitro evaluation of human enamel remineralization after treatment with Ginger, Ashwaganda and Maca herbal dentifrices versus commercially available fluoride containing dentifrice. 生姜、阿什瓦甘达和玛卡草药牙膏与市售含氟牙膏治疗后人牙釉质再矿化的体外评价
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-03 DOI: 10.1038/s41405-025-00298-9
Ghada Ahmed Elzayat, Fagr Hassan Elmergawy, Aya Abd ElFattah Mohammed Nemt Allah

Background: Compare the remineralization efficiency of Ginger, Ashwaghanda and Maca dentifrices versus commercially fluoride containing dentifrice.

Methods: Ginger, Ashwaghanda and Maca extracts were prepared by solvent extraction methodology and were characterized using transmission electron microscope, dynamic light scattering, and inductively coupled plasma optical emission spectrometer. The pH of the dentifrices was evaluated by pH meter. Eighty teeth were collected and divided into five groups according to the treatment protocol. Enamel morphology was carried out by scanning electron microscope with energy dispersive X-Ray spectroscopy for the analysis of calcium, phosphorus, Ca/P ratio and carbon. Surface microhardness was evaluated by Vickers micro-hardness tester. Data were analyzed using One-way ANOVA followed by Tukey's post hoc test (p ≤ 0.05).

Results: Characterization results showed the highest calcium, phosphorus and fluoride ion release were associated to Maca, Ashwaganda and Ginger respectively. The pH results revealed that Ginger dentifrice exhibited the most alkaline pH, whereas Ashwaganda dentifrice exhibited the most acidic pH. Morphological analysis revealed that Ashwaganda showed lower remineralization ability compared to the other treated groups. Maca showed significant higher Ca/P ratio compared to other groups (p < 0.001) and Ginger showed significant higher surface microhardness recovery compared to Ashwaganda (p < 0.001).

Conclusion: Ginger and Maca are promising remineralizing agents.

背景:比较生姜、Ashwaghanda和Maca牙膏与市售含氟牙膏的再矿化效率。方法:采用溶剂萃取法制备姜、阿什waghanda和玛咖提取物,采用透射电镜、动态光散射和电感耦合等离子体发射光谱仪对其进行表征。用pH计测定牙液的pH值。收集80颗牙齿,根据治疗方案分为5组。采用扫描电镜观察牙釉质形态,x射线能谱分析牙釉质钙、磷、钙磷比和碳含量。采用维氏显微硬度计测定表面显微硬度。数据分析采用单因素方差分析和Tukey事后检验(p≤0.05)。结果:表征结果显示,钙、磷、氟离子释放量最高的分别为玛咖、阿什瓦甘和姜。pH值结果显示,生姜牙的pH值碱性最强,而阿什瓦根牙的pH值酸性最强。形态学分析表明,阿什瓦根牙的再矿化能力低于其他处理组。结论:生姜和玛咖是很有前途的再矿化剂。
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引用次数: 0
Predictive factors for insertion torque values in transalveolar sinus lift procedures. 经肺泡窦提升术中插入扭矩值的预测因素。
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-03-03 DOI: 10.1038/s41405-025-00297-w
Ziad Albash, Ali Khalil

Objectives: The objective of this retrospective study was to investigate the impact of bone-related factors such as initial bone height (IBH), imaginary pixel unit (IPU), bone diameter (BD), crestal cortical thickness (CCT), and sinus floor thickness (SFT) in transalveolar sinus lift procedures using threaded bone expanders without bone graft materials.

Materials and methods: This retrospective cohort study was carried out on patients who had reported to the department of oral and maxillofacial surgery at Tishreen University between January 2018 and June 2024. The sample consisted of patients who had transalveolar sinus lift using motorized threaded bone expanders with simultaneous hybrid dental implants placement without bone graft materials. The bone-related factors, including initial bone height (IBH), imaginary pixel unit (IPU), bone diameter (BD), crestal cortical thickness (CCT), and sinus floor thickness (SFT) were analyzed using CBCT scans that were taken preoperatively. Statistical analysis was performed to assess the relationship of the factors and insertion torque of the dental implant. The statistical analysis includes descriptive statistics for all variables mentioned. A Uni-variate linear regression (Spearman's correlation) and multivariate linear regression were performed to assess the relation between Insertion torque and the explanatory variables. The p values < 0.05 were considered to be statistically significant. The Newey West correction for heteroskedasticity was applied.

Results: In this retrospective study, 124 hybrid implants (cylindrical in coronal section and conical in apical section) were placed in 113 patients (53 males and 60 females) in the posterior region of the maxilla in conjunction with transalveolar sinus lift. In the Uni-variate analysis, we observed a strong positive correlation between IT and IPU, a weak positive correlation between IT and SFT, and between IT and CCT. There was no correlation found between IT and IBH, as well as between IT and BD. Through multivariate analysis, we found that IPU and CCT were associated with higher values of IT, whereas IBH, BD, and SFT were not significantly associated with the value of insertion torque.

Conclusions: Our study indicates that, within its limitations, insertion torque values in transalveolar sinus lift procedures using threaded bone expanders and hybrid implants are primarily influenced by cortical bone thickness and imaginary pixel unit, while factors such as sinus floor thickness, initial bone height, and bone diameter do not significantly affect these values.

目的:本回顾性研究的目的是探讨骨相关因素,如初始骨高度(IBH),想象像素单位(IPU),骨直径(BD),嵴皮质厚度(CCT)和窦底厚度(SFT)在无骨移植材料的螺纹骨扩张器经牙槽窦提升手术中的影响。材料与方法:回顾性队列研究对象为2018年1月至2024年6月在天津大学口腔颌面外科就诊的患者。样本包括使用电动螺纹骨扩张器同时放置混合牙种植体而不使用骨移植材料的经牙槽窦提升患者。通过术前CBCT扫描分析骨相关因素,包括初始骨高(IBH)、想象像素单位(IPU)、骨径(BD)、嵴皮质厚度(CCT)和窦底厚度(SFT)。统计分析各因素与种植体插入力矩的关系。统计分析包括对上述所有变量的描述性统计。采用单变量线性回归(Spearman相关)和多变量线性回归来评估插入扭矩与解释变量之间的关系。结果:在本回顾性研究中,113例患者(男53例,女60例)在上颌骨后区放置124个混合种植体(冠状面为圆柱形,根尖面为圆锥形),并结合经牙槽窦提升。在单变量分析中,我们观察到IT与IPU之间存在强正相关,IT与SFT之间存在弱正相关,IT与CCT之间存在弱正相关。通过多变量分析,我们发现IPU和CCT与较高的IT值相关,而IBH、BD和SFT与插入扭矩值无显著相关。结论:我们的研究表明,在其局限性内,使用螺纹骨扩张器和混合种植体的经牙槽窦提升手术的插入扭矩值主要受皮质骨厚度和想象像素单位的影响,而窦底厚度、初始骨高度和骨直径等因素对这些值没有显著影响。
{"title":"Predictive factors for insertion torque values in transalveolar sinus lift procedures.","authors":"Ziad Albash, Ali Khalil","doi":"10.1038/s41405-025-00297-w","DOIUrl":"10.1038/s41405-025-00297-w","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this retrospective study was to investigate the impact of bone-related factors such as initial bone height (IBH), imaginary pixel unit (IPU), bone diameter (BD), crestal cortical thickness (CCT), and sinus floor thickness (SFT) in transalveolar sinus lift procedures using threaded bone expanders without bone graft materials.</p><p><strong>Materials and methods: </strong>This retrospective cohort study was carried out on patients who had reported to the department of oral and maxillofacial surgery at Tishreen University between January 2018 and June 2024. The sample consisted of patients who had transalveolar sinus lift using motorized threaded bone expanders with simultaneous hybrid dental implants placement without bone graft materials. The bone-related factors, including initial bone height (IBH), imaginary pixel unit (IPU), bone diameter (BD), crestal cortical thickness (CCT), and sinus floor thickness (SFT) were analyzed using CBCT scans that were taken preoperatively. Statistical analysis was performed to assess the relationship of the factors and insertion torque of the dental implant. The statistical analysis includes descriptive statistics for all variables mentioned. A Uni-variate linear regression (Spearman's correlation) and multivariate linear regression were performed to assess the relation between Insertion torque and the explanatory variables. The p values < 0.05 were considered to be statistically significant. The Newey West correction for heteroskedasticity was applied.</p><p><strong>Results: </strong>In this retrospective study, 124 hybrid implants (cylindrical in coronal section and conical in apical section) were placed in 113 patients (53 males and 60 females) in the posterior region of the maxilla in conjunction with transalveolar sinus lift. In the Uni-variate analysis, we observed a strong positive correlation between IT and IPU, a weak positive correlation between IT and SFT, and between IT and CCT. There was no correlation found between IT and IBH, as well as between IT and BD. Through multivariate analysis, we found that IPU and CCT were associated with higher values of IT, whereas IBH, BD, and SFT were not significantly associated with the value of insertion torque.</p><p><strong>Conclusions: </strong>Our study indicates that, within its limitations, insertion torque values in transalveolar sinus lift procedures using threaded bone expanders and hybrid implants are primarily influenced by cortical bone thickness and imaginary pixel unit, while factors such as sinus floor thickness, initial bone height, and bone diameter do not significantly affect these values.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"23"},"PeriodicalIF":2.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Posture analysis during tooth extraction. 纠正:拔牙时的姿势分析。
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-25 DOI: 10.1038/s41405-025-00313-z
Takashi Fukushima, Keisuke Sugahara, Kazuhiro Ito, Masahide Koyachi, Akihiro Nishiyama, Chihiro Kurihara, Shintaro Nakajima, Satoru Matsunaga, Akira Katakura
{"title":"Correction: Posture analysis during tooth extraction.","authors":"Takashi Fukushima, Keisuke Sugahara, Kazuhiro Ito, Masahide Koyachi, Akihiro Nishiyama, Chihiro Kurihara, Shintaro Nakajima, Satoru Matsunaga, Akira Katakura","doi":"10.1038/s41405-025-00313-z","DOIUrl":"10.1038/s41405-025-00313-z","url":null,"abstract":"","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"21"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Efficacy of oral irrigators compared to other interdental aids for managing peri-implant diseases: a systematic review. 纠正:与其他牙间辅助设备相比,口腔冲洗器治疗种植体周围疾病的疗效:一项系统综述。
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-20 DOI: 10.1038/s41405-025-00312-0
Gargi Gandhi, Bhoomika Sai Laxmi Masanam, Ananya Sudhakaran Nair, Nidhi Semani, Aditi Chopra, Venkitachalam Ramanarayanan
{"title":"Correction: Efficacy of oral irrigators compared to other interdental aids for managing peri-implant diseases: a systematic review.","authors":"Gargi Gandhi, Bhoomika Sai Laxmi Masanam, Ananya Sudhakaran Nair, Nidhi Semani, Aditi Chopra, Venkitachalam Ramanarayanan","doi":"10.1038/s41405-025-00312-0","DOIUrl":"10.1038/s41405-025-00312-0","url":null,"abstract":"","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"19"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of magnesium-based scaffolds fabricated using a modified sintering technique and two types of space holding agents (in vitro study). 对使用改良烧结技术和两种空间保持剂制作的镁基支架的评估(体外研究)。
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-20 DOI: 10.1038/s41405-025-00299-8
Omnia Ghabour, Nahla Taha, Salma Aboul Gheit, Mona Mohy El Din

Objective: The aim of this work was to study the mechanical, degradation behavior and bioactivity of porous magnesium-based scaffolds alloyed with zinc and hydroxyapatite, fabricated using two different types of space holding agents and a modified powder metallurgy route.

Methods: Powder particles of magnesium, zinc, hydroxyapatite (HA) and spacers were mixed, then mixtures were divided into 6 groups: IA (urea/0%HA), IB (urea/5%HA), IC (urea/7.5%HA), IIA (ammonium bicarbonate/0%HA), IIB (ammonium bicarbonate/5%HA) and IIC (ammonium bicarbonate/7.5%HA). A modified powder metallurgy route was used to fabricate the composites. Porosity analysis and microstructural characterization using Scanning Electron Microscope (SEM), Energy Dispersive X-ray Analysis (EDX), and X-ray Diffraction Analysis (XRD) were done. Evaluation of mechanical properties, in-vitro degradation rate in simulated body fluid (SBF) and in-vitro bioactivity using SEM and XRD were done. Data were statistically analyzed using two-way and three-way repeated ANOVA tests.

Results: All scaffolds were found to be highly porous. Significant differences were observed regarding mechanical properties, degradation rate and concentration of magnesium released during degradation (P  < 0.0001). The results showed that group IIB had the lowest strength and fastest corrosion rate, while IB had the highest strength and elastic modulus and the slowest corrosion rate among all groups. Bioactivity evaluation revealed extensive formation of calcium phosphate crystals and precipitations covering the scaffolds' surfaces.

Conclusion: This study showed that using up to 5% HA as a reinforcing element with moderate compaction pressure and urea as a space holding agent can result in the fabrication of magnesium scaffolds suitable for orthopedic applications.

目的:研究锌羟基磷灰石复合多孔镁基支架材料的力学性能、降解性能和生物活性。该材料采用两种不同的空间保持剂和改性粉末冶金工艺制备。方法:将镁、锌、羟基磷灰石(HA)粉末颗粒和间隔剂混合,将混合物分为IA(尿素/0%HA)、IB(尿素/5%HA)、IC(尿素/7.5%HA)、IIA(碳酸氢铵/0%HA)、IIB(碳酸氢铵/5%HA)和IIC(碳酸氢铵/7.5%HA) 6组。采用改进的粉末冶金工艺制备复合材料。利用扫描电镜(SEM)、能量色散x射线分析(EDX)和x射线衍射分析(XRD)对样品进行了孔隙度分析和微观结构表征。利用扫描电镜(SEM)和x射线衍射(XRD)对其力学性能、体外模拟体液降解率和体外生物活性进行了评价。数据采用双向和三向重复方差分析进行统计学分析。结果:所有支架均具有高多孔性。在力学性能、降解速率和降解过程中释放的镁的浓度方面观察到显著的差异(P结论:本研究表明,使用高达5%的HA作为适度压实压力的增强元素,尿素作为空间保持剂,可以制造出适合骨科应用的镁支架。
{"title":"Evaluation of magnesium-based scaffolds fabricated using a modified sintering technique and two types of space holding agents (in vitro study).","authors":"Omnia Ghabour, Nahla Taha, Salma Aboul Gheit, Mona Mohy El Din","doi":"10.1038/s41405-025-00299-8","DOIUrl":"10.1038/s41405-025-00299-8","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this work was to study the mechanical, degradation behavior and bioactivity of porous magnesium-based scaffolds alloyed with zinc and hydroxyapatite, fabricated using two different types of space holding agents and a modified powder metallurgy route.</p><p><strong>Methods: </strong>Powder particles of magnesium, zinc, hydroxyapatite (HA) and spacers were mixed, then mixtures were divided into 6 groups: IA (urea/0%HA), IB (urea/5%HA), IC (urea/7.5%HA), IIA (ammonium bicarbonate/0%HA), IIB (ammonium bicarbonate/5%HA) and IIC (ammonium bicarbonate/7.5%HA). A modified powder metallurgy route was used to fabricate the composites. Porosity analysis and microstructural characterization using Scanning Electron Microscope (SEM), Energy Dispersive X-ray Analysis (EDX), and X-ray Diffraction Analysis (XRD) were done. Evaluation of mechanical properties, in-vitro degradation rate in simulated body fluid (SBF) and in-vitro bioactivity using SEM and XRD were done. Data were statistically analyzed using two-way and three-way repeated ANOVA tests.</p><p><strong>Results: </strong>All scaffolds were found to be highly porous. Significant differences were observed regarding mechanical properties, degradation rate and concentration of magnesium released during degradation (P  < 0.0001). The results showed that group IIB had the lowest strength and fastest corrosion rate, while IB had the highest strength and elastic modulus and the slowest corrosion rate among all groups. Bioactivity evaluation revealed extensive formation of calcium phosphate crystals and precipitations covering the scaffolds' surfaces.</p><p><strong>Conclusion: </strong>This study showed that using up to 5% HA as a reinforcing element with moderate compaction pressure and urea as a space holding agent can result in the fabrication of magnesium scaffolds suitable for orthopedic applications.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"20"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attractiveness and determinants of maxillary midline diastemas in a West African smile. 西非微笑中上颌中线间隙的吸引力和决定因素。
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-18 DOI: 10.1038/s41405-025-00302-2
Sefaakor Ahiaku, Brian J Millar, Michael Cronin

Introduction: This cross-sectional study examines whether the assumption that diastemas of 1 mm or greater are un-attractive is true in a Black West-African population, and identifies the determinants of attractiveness.

Methods: A structured questionnaire was self-administered to adult participants, who rated digitally altered full-face colour photographs of a male and female model with diastema widths of 0-6 mm on a 5-point Likert scale. Quantitative data was analysed using SAS® (version 9.4) and SPSS® (version 26). Qualitative data was analysed with thematic analysis.

Results: 375 participants completed the questionnaire (51% female, 48% male, 1% preferred not to disclose) with a modal age of 25-34. 65% of participants found maxillary midline diastema esthetic and/or desirable, with 63% of those with diastemas choosing to have no treatment, and the desire to have treatment decreasing with increasing age (p = 0.012). No smile was perceived to be unattractive, however female smiles were rated more favourably (p < 0.001) and increasing diastema width correlated with a decreasing attractiveness especially for diastemas wider than 3 mm in females and 2 mm in males. Diastema width, the gender of the model, and whether or not the participant had a diastema themselves was shown to impact perceptions of attractiveness in a multi-variable analysis.

Conclusion: There is limited evidence to support the position that MMDs over 1 mm are not attractive in this population. Diastemas of ≤3 mm in females and ≤2 mm in males are considered attractive. In addition gender, diastema width, and an individual's own diastema (or absence thereof) impact perceived attractiveness.

本横断面研究探讨了1毫米或更大的裂口在西非黑人人群中是否不具有吸引力的假设,并确定了吸引力的决定因素。方法:对成年参与者自行进行结构化问卷调查,他们以5分李克特量表对隔膜宽度为0-6毫米的男性和女性模特的数字修改的全脸彩色照片进行评分。定量数据采用SAS®(version 9.4)和SPSS®(version 26)进行分析。对定性数据进行专题分析。结果:375名参与者完成了问卷(51%女性,48%男性,1%不愿透露),模态年龄为25-34岁。65%的参与者认为上颌中线隔膜美观和/或理想,63%的隔膜患者选择不进行治疗,并且随着年龄的增长,治疗的愿望减少(p = 0.012)。没有微笑的人被认为是不吸引人的,然而女性的微笑被认为是更有吸引力的(p结论:有有限的证据支持mmd超过1毫米在这个人群中没有吸引力的观点。雌性裂口≤3mm,雄性裂口≤2mm被认为是有吸引力的。此外,性别、隔膜宽度和个体自身的隔膜(或不存在隔膜)影响感知吸引力。
{"title":"Attractiveness and determinants of maxillary midline diastemas in a West African smile.","authors":"Sefaakor Ahiaku, Brian J Millar, Michael Cronin","doi":"10.1038/s41405-025-00302-2","DOIUrl":"10.1038/s41405-025-00302-2","url":null,"abstract":"<p><strong>Introduction: </strong>This cross-sectional study examines whether the assumption that diastemas of 1 mm or greater are un-attractive is true in a Black West-African population, and identifies the determinants of attractiveness.</p><p><strong>Methods: </strong>A structured questionnaire was self-administered to adult participants, who rated digitally altered full-face colour photographs of a male and female model with diastema widths of 0-6 mm on a 5-point Likert scale. Quantitative data was analysed using SAS® (version 9.4) and SPSS® (version 26). Qualitative data was analysed with thematic analysis.</p><p><strong>Results: </strong>375 participants completed the questionnaire (51% female, 48% male, 1% preferred not to disclose) with a modal age of 25-34. 65% of participants found maxillary midline diastema esthetic and/or desirable, with 63% of those with diastemas choosing to have no treatment, and the desire to have treatment decreasing with increasing age (p = 0.012). No smile was perceived to be unattractive, however female smiles were rated more favourably (p < 0.001) and increasing diastema width correlated with a decreasing attractiveness especially for diastemas wider than 3 mm in females and 2 mm in males. Diastema width, the gender of the model, and whether or not the participant had a diastema themselves was shown to impact perceptions of attractiveness in a multi-variable analysis.</p><p><strong>Conclusion: </strong>There is limited evidence to support the position that MMDs over 1 mm are not attractive in this population. Diastemas of ≤3 mm in females and ≤2 mm in males are considered attractive. In addition gender, diastema width, and an individual's own diastema (or absence thereof) impact perceived attractiveness.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"17"},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Findings from computed tomography examinations of Viking age skulls. 维京时代头骨的计算机断层扫描检查结果。
IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-18 DOI: 10.1038/s41405-025-00309-9
Carolina Bertilsson, Eva Borg, Maria Vretemark, Henrik Lund

Introduction: Computed tomography (CT) images can provide information about anatomical structures and pathological processes in ancient skulls. A previous study on the teeth and jaws of 171 individuals in a late Swedish Viking age population, dating around the 10th-12th century made clinical examinations that included intraoral radiographs. Current explorative study examined a subset of this population using CT with the aim to investigate if this method could provide additional information about the studied subjects.

Materials and method: The skulls of 15 Viking-era individuals were examined with CT. Two specialists in oral and maxillofacial radiology and one general dentist examined the images together, performing the diagnostics and interpretated the results.

Results: Findings included signs of pathological conditions of the teeth; of the alveolar, mandibular, maxillary and auricular bone; and of the paranasal sinuses and temporomandibular joints. These findings indicated the presence of both clinically detectable conditions, such as dental caries, periodontal disease, periapical destructions and remodelling of the caput mandibulae, but also additional findings such as sclerotization of the mastoid process, infection-induced periosteal bone deposition, and signs of sinusitis.

Conclusion: CT investigation of skeletal remains from an early Christian community in the Viking era in Sweden indicated that the population suffered from numerous orofacial pathologies, including dental disease, sinusitis, otitis, and various infections. The current study, using CT as an investigation method of skeletal remains, indicated that this method could identify conditions that might be difficult to find through ocular inspection. Conclusively, CT is suggested to be an important non-invasive method when used in combination with other examination methods, possibly providing additional information about archeological human remains. Further studies on similar samples are suggested to examine this further.

计算机断层扫描(CT)图像可以提供有关古代颅骨解剖结构和病理过程的信息。先前的一项研究对大约10 -12世纪瑞典维京人晚期的171个人的牙齿和颌骨进行了临床检查,其中包括口内x光片。目前的探索性研究使用CT检查了这一人群的一个子集,目的是调查这种方法是否可以提供有关被研究对象的额外信息。材料与方法:对15例维京时代个体的颅骨进行了CT检查。两名口腔颌面放射学专家和一名普通牙医一起检查图像,进行诊断并解释结果。结果:检查结果包括牙齿病理状况的迹象;牙槽骨、下颌骨、上颌骨和耳骨;还有副鼻窦和颞下颌关节。这些发现表明存在临床可检测的情况,如龋齿、牙周病、根尖周破坏和下颌头重塑,但也有其他发现,如乳突硬化、感染引起的骨膜骨沉积和鼻窦炎的迹象。结论:对瑞典维京时代早期基督教社区的骨骼遗骸进行的CT调查表明,该人群患有多种口腔面部疾病,包括牙病、鼻窦炎、中耳炎和各种感染。目前的研究使用CT作为骨骼遗骸的调查方法,表明这种方法可以识别通过眼睛检查可能难以发现的疾病。最后,CT被认为是一种重要的非侵入性方法,当与其他检查方法结合使用时,可能提供关于考古人类遗骸的额外信息。建议对类似样品进行进一步的研究以进一步检验这一点。
{"title":"Findings from computed tomography examinations of Viking age skulls.","authors":"Carolina Bertilsson, Eva Borg, Maria Vretemark, Henrik Lund","doi":"10.1038/s41405-025-00309-9","DOIUrl":"10.1038/s41405-025-00309-9","url":null,"abstract":"<p><strong>Introduction: </strong>Computed tomography (CT) images can provide information about anatomical structures and pathological processes in ancient skulls. A previous study on the teeth and jaws of 171 individuals in a late Swedish Viking age population, dating around the 10<sup>th</sup>-12<sup>th</sup> century made clinical examinations that included intraoral radiographs. Current explorative study examined a subset of this population using CT with the aim to investigate if this method could provide additional information about the studied subjects.</p><p><strong>Materials and method: </strong>The skulls of 15 Viking-era individuals were examined with CT. Two specialists in oral and maxillofacial radiology and one general dentist examined the images together, performing the diagnostics and interpretated the results.</p><p><strong>Results: </strong>Findings included signs of pathological conditions of the teeth; of the alveolar, mandibular, maxillary and auricular bone; and of the paranasal sinuses and temporomandibular joints. These findings indicated the presence of both clinically detectable conditions, such as dental caries, periodontal disease, periapical destructions and remodelling of the caput mandibulae, but also additional findings such as sclerotization of the mastoid process, infection-induced periosteal bone deposition, and signs of sinusitis.</p><p><strong>Conclusion: </strong>CT investigation of skeletal remains from an early Christian community in the Viking era in Sweden indicated that the population suffered from numerous orofacial pathologies, including dental disease, sinusitis, otitis, and various infections. The current study, using CT as an investigation method of skeletal remains, indicated that this method could identify conditions that might be difficult to find through ocular inspection. Conclusively, CT is suggested to be an important non-invasive method when used in combination with other examination methods, possibly providing additional information about archeological human remains. Further studies on similar samples are suggested to examine this further.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":"11 1","pages":"18"},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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