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Symptom-Driven Personalized Proton Pump Inhibitors Therapy Using Bayesian Neural Networks and Model Predictive Control 使用贝叶斯神经网络和模型预测控制的症状驱动个性化质子泵抑制剂治疗
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-22 DOI: 10.1109/LCSYS.2025.3647098
Yutong Li;Ilya Kolmanovsky
Proton Pump Inhibitors (PPIs) are the standard of care for gastric acid disorders but carry significant risks when administered chronically at high doses. Precise long-term control of gastric acidity is challenged by the impracticality of invasive gastric acid monitoring beyond 72 hours and wide inter-patient variability. We propose a noninvasive, symptom-based framework that tailors PPI dosing solely on patient-reported reflux and digestive symptom patterns. A Bayesian Neural Network (BNN) prediction model learns to predict patient symptoms and quantifies its uncertainty from historical symptom scores, meal, and PPIs intake data. These probabilistic forecasts feed a chance-constrained Model Predictive Control (MPC) algorithm that dynamically computes future PPI doses to minimize drug usage while enforcing acid suppression with high confidence—without any direct acid measurement. In silico studies over diverse dietary schedules and virtual patient profiles demonstrate that our learning-augmented MPC reduces total PPI consumption by 65% compared to standard fixed regimens, while maintaining acid suppression with at least 95% probability. The proposed approach offers a practical path to personalized PPI therapy, minimizing treatment burden and overdose risk without invasive sensors.
质子泵抑制剂(PPIs)是胃酸紊乱的标准治疗,但长期高剂量使用会带来显著风险。由于超过72小时的侵入性胃酸监测的不可行性和患者之间的广泛差异,对胃酸的精确长期控制提出了挑战。我们提出一个无创的、基于症状的框架,仅根据患者报告的反流和消化症状模式来调整PPI剂量。贝叶斯神经网络(BNN)预测模型学习预测患者症状,并从历史症状评分、膳食和PPIs摄入数据中量化其不确定性。这些概率预测提供给机会约束模型预测控制(MPC)算法,该算法动态计算未来PPI剂量,以最大限度地减少药物使用,同时在没有任何直接酸测量的情况下,以高可信度实施酸抑制。在不同饮食计划和虚拟患者资料的计算机研究表明,与标准固定方案相比,我们的学习增强MPC减少了总PPI消耗65%,同时保持酸抑制的概率至少为95%。提出的方法为个性化PPI治疗提供了一条实用的途径,在没有侵入性传感器的情况下,将治疗负担和用药过量风险降至最低。
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引用次数: 0
Safe Bayesian Optimization Across Noise Models via Scenario Programming 基于场景规划的噪声模型安全贝叶斯优化
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-18 DOI: 10.1109/LCSYS.2025.3645824
Abdullah Tokmak;Thomas B. Schön;Dominik Baumann
Safe Bayesian optimization (BO) with Gaussian processes is an effective tool for tuning control policies in safety-critical real-world systems, specifically due to its sample efficiency and safety guarantees. However, most safe BO algorithms assume homoscedastic sub-Gaussian measurement noise, an assumption that does not hold in many relevant applications. In this letter, we propose a straightforward yet rigorous approach for safe BO across noise models, including homoscedastic sub-Gaussian and heteroscedastic heavy-tailed distributions. We provide a high-probability bound on the measurement noise via the scenario approach, integrate these bounds into high probability confidence intervals, and prove safety and optimality for our proposed safe BO algorithm. We deploy our algorithm in synthetic examples and in tuning a controller for the Franka Emika manipulator in simulation.
具有高斯过程的安全贝叶斯优化(BO)是在安全关键的现实系统中调整控制策略的有效工具,特别是由于它的样本效率和安全性保证。然而,大多数安全的BO算法假设均方差亚高斯测量噪声,这一假设在许多相关应用中并不成立。在这封信中,我们提出了一种简单而严格的方法,用于跨噪声模型的安全BO,包括均方差亚高斯分布和异方差重尾分布。我们通过场景方法提供测量噪声的高概率界,将这些界整合到高概率置信区间中,并证明了我们提出的安全BO算法的安全性和最优性。我们将我们的算法应用于合成实例,并在仿真中用于调整Franka Emika机械手的控制器。
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引用次数: 0
Stability Analysis of Fast Extremum Seeking Control for Wiener Systems Using Online Complex Curve Fitting 基于在线复杂曲线拟合的Wiener系统快速求极值控制稳定性分析
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-18 DOI: 10.1109/LCSYS.2025.3645829
Juan Javier Palacios Roman;Matthijs van Berkel;Maurice Heemels;Thijs van Keulen
In this letter, we show uniform semi-global practical asymptotic stability of fast extremum seeking control (ESC) for single-input single-output Wiener systems. While classic ESC requires a time-scale separation between plant and dither, the fast ESC method circumvents this time-scale separation by exploiting limited knowledge of the frequency response of the linear part of the Wiener system, thereby achieving faster convergence. The assumptions under which the fast ESC method works are relaxed compared to existing work and explicit bounds on the design parameters of the fast ESC scheme are provided. A numerical case study illustrates the enhanced convergence and the robustness of the fast ESC method.
在这篇文章中,我们证明了单输入单输出Wiener系统快速极值寻求控制(ESC)的一致半全局实用渐近稳定性。虽然经典ESC需要在植物和抖动之间进行时间尺度分离,但快速ESC方法通过利用维纳系统线性部分的频率响应的有限知识来规避这种时间尺度分离,从而实现更快的收敛。与现有方法相比,放宽了快速ESC方法工作的假设条件,并给出了快速ESC方案设计参数的明确界限。算例研究表明,快速ESC方法具有较好的收敛性和鲁棒性。
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引用次数: 0
A Small-Gain Look at Cyber-Physical Security 网络物理安全的小收益分析
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-18 DOI: 10.1109/LCSYS.2025.3645825
Sayan Chakraborty;Zhong-Ping Jiang
This letter studies the resilience of cyber-physical systems under denial-of-service attacks. We develop a novel framework for resilient control that avoids the need for detailed information about the system or attacker dynamics by treating the plant–attacker interaction as an interconnected system. Using small-gain analysis and switching systems theory, we derive explicit resilience conditions, and employ reinforcement learning to synthesize an optimal policy directly from input–state data, estimating the required small-gain bounds in a data-driven manner. A numerical example illustrates the effectiveness of the proposed approach.
这封信研究了网络物理系统在拒绝服务攻击下的弹性。我们开发了一种新的弹性控制框架,通过将植物-攻击者交互视为一个相互关联的系统,避免了对系统或攻击者动态详细信息的需要。利用小增益分析和开关系统理论,我们推导出明确的弹性条件,并采用强化学习直接从输入状态数据合成最优策略,以数据驱动的方式估计所需的小增益边界。数值算例说明了该方法的有效性。
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引用次数: 0
Optimism as Risk-Seeking in Multi-Agent Reinforcement Learning 多智能体强化学习中的乐观主义风险寻求
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-17 DOI: 10.1109/LCSYS.2025.3645109
Runyu Zhang;Na Li;Asuman Ozdaglar;Jeff Shamma;Gioele Zardini
Risk sensitivity has become a central theme in reinforcement learning (RL), where convex risk measures and robust formulations provide principled ways to model preferences beyond expected return. Recent extensions to multi-agent RL (MARL) have largely emphasized the risk-averse setting, prioritizing robustness to uncertainty. In cooperative MARL, however, such conservatism often leads to suboptimal equilibria, and a parallel line of work has shown that optimism can promote cooperation. Existing optimistic methods, though effective in practice, are typically heuristic and lack theoretical grounding. Building on the dual representation for convex risk measures, we propose a principled framework that interprets risk-seeking objectives as optimism. We introduce optimistic value functions, which formalize optimism as divergence-penalized risk-seeking evaluations. Building on this foundation, we derive a policy-gradient theorem for optimistic value functions, including explicit formulas for the entropic risk/KL-penalty setting, and develop decentralized optimistic actor-critic algorithms that implement these updates. Empirical results on cooperative benchmarks demonstrate that risk-seeking optimism consistently improves coordination over both risk-neutral baselines and heuristic optimistic methods. Our framework thus unifies risk-sensitive learning and optimism, offering a theoretically grounded and practically effective approach to cooperation in MARL.
风险敏感性已经成为强化学习(RL)的中心主题,其中凸风险度量和鲁棒公式提供了超越预期回报的偏好建模的原则方法。最近对多智能体强化学习(MARL)的扩展在很大程度上强调了风险规避设置,将鲁棒性优先于不确定性。然而,在合作型MARL中,这种保守性往往会导致次优均衡,而一条平行线表明,乐观主义可以促进合作。现有的乐观方法虽然在实践中是有效的,但往往是启发式的,缺乏理论依据。在凸风险度量的对偶表示的基础上,我们提出了一个原则性框架,将风险寻求目标解释为乐观主义。我们引入乐观价值函数,将乐观形式化为发散惩罚风险寻求评估。在此基础上,我们推导了乐观值函数的策略梯度定理,包括熵风险/ kl -惩罚设置的显式公式,并开发了实现这些更新的分散乐观行为者批评算法。合作基准的实证结果表明,风险寻求乐观主义在风险中性基准和启发式乐观方法上都能持续改善协调。因此,我们的框架将风险敏感学习和乐观主义结合起来,为MARL合作提供了理论基础和实践有效的方法。
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引用次数: 0
Heterogeneous Pursuit of an Active Target Under Sensing Constraints 传感约束下主动目标的异构跟踪
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-17 DOI: 10.1109/LCSYS.2025.3645033
Prajakta Surve;Shaunak D. Bopardikar;Alexander Von Moll;Isaac Weintraub;David W. Casbeer
This letter studies a heterogeneous three-agent pursuit-evasion scenario in which a sensor–attacker team attempts to capture an active target capable of changing its heading at fixed time intervals. The sensor has a limited sensing range, and the attacker must intercept the target before it escapes sensing. We formulate this problem as a game of kind and extend the optimal sensor and attacker strategies from prior work on passive targets to the active target setting. The sensor updates its heading in each interval by assuming that the target will keep its heading fixed for the rest of the engagement, while the attacker uses an Apollonius circle-based approach for minimum-time interception and updating its heading corresponding to the target heading in every interval. We show that the conditions for capture or escape of a passive target also extend to the case of an active target. In particular, if the speed of the active target is less than a critical value identified for passive targets in our prior work, then capture is guaranteed.
这封信研究了一个异构的三代理追捕逃避场景,其中一个传感器攻击者团队试图捕获一个能够以固定的时间间隔改变其航向的活动目标。传感器的感知范围有限,攻击者必须在目标逃脱感知之前拦截目标。我们将此问题表述为一类博弈,并将最优传感器和攻击者策略从先前的被动目标工作扩展到主动目标设置。传感器通过假设目标将在剩余的交战时间内保持其航向固定,在每个间隔更新其航向,而攻击者使用基于阿波罗尼乌斯圆的方法进行最小时间拦截,并在每个间隔更新其航向对应于目标航向。我们证明了被动目标的捕获或逃脱的条件也延伸到主动目标的情况下。特别是,如果主动目标的速度小于我们在之前的工作中为被动目标确定的临界值,那么捕获是保证的。
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引用次数: 0
Safe Navigation in the Presence of Range-Limited Pursuers 在距离有限的追踪者存在下的安全导航
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-17 DOI: 10.1109/LCSYS.2025.3645221
Thomas Chapman;Alexander Von Moll;Isaac E. Weintraub
This letter examines the degree to which an evader seeking a safe and efficient path to a target location can benefit from increasing levels of knowledge regarding one or more range-limited pursuers seeking to intercept it. Unlike previous work, this letter considers the time of flight of the pursuers actively attempting interception. It is shown that additional knowledge allows the evader to safely steer closer to the threats, shortening paths without accepting additional risk of capture. A control heuristic is presented, suitable for real-time implementation, which capitalizes on all knowledge available to the evader.
这封信考察了寻求安全有效路径到目标位置的逃避者在多大程度上可以从寻求拦截它的一个或多个范围有限的追踪者的不断提高的知识水平中受益。与以前的工作不同,这封信考虑了主动尝试拦截的追击者的飞行时间。研究表明,额外的知识允许逃避者安全地转向更接近威胁,缩短路径而不接受额外的捕获风险。提出了一种适合于实时实现的控制启发式算法,该算法充分利用了逃避者可用的所有知识。
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引用次数: 0
Safety-Certified Planning and Control in Dynamic Environments via Model Predictive Control 基于模型预测控制的动态环境下安全认证规划与控制
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-15 DOI: 10.1109/LCSYS.2025.3644797
Marjan Khaledi;Bahare Kiumarsi
This letter proposes a novel approach to safe navigation in environments with static and dynamic obstacles by embedding control barrier functions (CBFs) within the model predictive control (MPC) framework. Unlike conventional methods that rely on unbounded additive slack variables, the proposed approach enforces each CBF constraint separately, allowing individual flexibility through dedicated slack variables with bounded relaxation weights. These weights modulate the permissible degree of constraint relaxation, ensuring that any safety softening remains quantitatively bounded, systematically tunable, and theoretically consistent with the CBF-based safety guaranties. Furthermore, the feasibility of the proposed approach is guaranteed, and the effectiveness of our method is demonstrated through the simulation results.
这封信通过在模型预测控制(MPC)框架内嵌入控制障碍函数(cbf),提出了一种在静态和动态障碍环境中安全导航的新方法。与依赖无界附加松弛变量的传统方法不同,该方法单独执行每个CBF约束,通过具有有界松弛权的专用松弛变量实现个体灵活性。这些权重调节约束松弛的允许程度,确保任何安全软化都保持定量限制,系统可调,并且理论上与基于cbf的安全保证一致。最后,通过仿真结果验证了该方法的有效性。
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引用次数: 0
Certifying the Nonexistence of Feasible Paths Between Power System Operating Points 电力系统运行点之间不存在可行路径的证明
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-15 DOI: 10.1109/LCSYS.2025.3644800
Mohammad Rasoul Narimani;Katherine R. Davis;Daniel K. Molzahn
By providing the optimal operating point that satisfies both the power flow equations and engineering limits, the optimal power flow (OPF) problem is central to power systems operations. While extensive research has focused on computing high-quality OPF solutions, assessing the feasibility of transitioning between operating points remains challenging since the feasible spaces of OPF problems may consist of multiple disconnected components. It is not possible to transition between operating points in different disconnected components without violating OPF constraints. To identify such situations, this letter introduces an algorithm for certifying the infeasibility of transitioning between two operating points within an OPF feasible space. As an indication of potential disconnectedness, the algorithm first seeks an infeasible point on the line connecting a pair of feasible points. The algorithm then certifies disconnectedness by using convex relaxation and bound tightening techniques to show that all points on the plane that is normal to this line are infeasible. Using this algorithm, we provide the first certifications of disconnected feasible spaces for a variety of OPF test cases.
最优潮流(OPF)问题是电力系统运行的核心问题,它提供了既满足潮流方程又满足工程极限的最优工作点。虽然广泛的研究集中在计算高质量的OPF解决方案上,但由于OPF问题的可行空间可能由多个不相连的组件组成,因此评估工作点之间转换的可行性仍然具有挑战性。在不违反OPF约束的情况下,不可能在不同断开组件的工作点之间进行转换。为了识别这种情况,本函引入了一种算法,用于证明在OPF可行空间内两个工作点之间过渡的不可行性。作为潜在不连通的指示,该算法首先在连接一对可行点的直线上寻找一个不可行点。然后,该算法通过使用凸松弛和约束收紧技术来证明断开性,以表明平面上与该直线垂直的所有点都是不可行的。使用该算法,我们为各种OPF测试用例提供了第一个断开可行空间的认证。
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引用次数: 0
Arbitration With Control Barrier Functions for Safe Shared Control 具有控制屏障功能的安全共享控制仲裁
IF 2 Q2 AUTOMATION & CONTROL SYSTEMS Pub Date : 2025-12-10 DOI: 10.1109/LCSYS.2025.3642534
M. Yusuf Uzun;Yildiray Yildiz
By combining automation accuracy with human adaptability, shared control provides enhanced performance and safety in dynamic, complex environments. Traditional arbitration methods for integrating automation and human inputs often rely on system-specific, parameter-dependent functions that are based on shared control metrics such as trust, workload, or attention. Meanwhile, Control Barrier Functions (CBFs) enforce safety constraints on automated systems but are typically limited to safeguarding plant states. This letter introduces a novel arbitration method based on Control Barrier Functions (CBFs), where shared control metrics such as workload, attention, and trust are expressed as real-time inequality constraints. The resulting quadratic-programming formulation determines the automation assistance input that enforces these constraints while preserving feasibility and safety. This CBF-based arbitration provides a systematic, interpretable, and scalable foundation for safe human–autonomy integration.
通过将自动化精度与人的适应性相结合,共享控制在动态、复杂的环境中提供了增强的性能和安全性。集成自动化和人工输入的传统仲裁方法通常依赖于基于共享控制度量(如信任、工作负载或注意力)的系统特定的、参数相关的功能。同时,控制屏障功能(cbf)对自动化系统实施安全约束,但通常仅限于保护工厂状态。这封信介绍了一种基于控制屏障函数(cbf)的新型仲裁方法,其中共享控制指标(如工作量,注意力和信任)表示为实时不等式约束。由此产生的二次规划公式确定了在保持可行性和安全性的同时执行这些约束的自动化辅助输入。这种基于cbf的仲裁为安全的人类自治集成提供了系统的、可解释的和可扩展的基础。
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引用次数: 0
期刊
IEEE Control Systems Letters
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