Obesity Medicine最新文献_第9页

Protein phosphatase 6 as an important downstream target of fibroblast growth 21 and its therapeutic analogues in attenuating MASH development 蛋白磷酸酶6作为成纤维细胞生长的重要下游靶点21及其治疗类似物在减轻MASH发展中的作用

Q2 Medicine

Obesity Medicine

Pub Date : 2025-03-24 DOI: 10.1016/j.obmed.2025.100602

Jia Nuo Feng , Qingchun Tong , Tianru Jin

引用次数: 0

Clinical evaluation of safety and efficacy of biozen syrup in patients with hyperlipidemia biozen糖浆治疗高脂血症的安全性和有效性的临床评价

Q2 Medicine

Obesity Medicine

Pub Date : 2025-03-21 DOI: 10.1016/j.obmed.2025.100601

Rajappan Chandra Satish Kumar , Subramaniam Nandhini , Bhuvaneshwaran Mothishwaran , Chittaranjan Das , Anavarathan Vallipuram , Muhasaparur Ganesan Rajanandh

Background

The increasing prevalence of hyperlipidemia has become one of the greatest threats to public health. While pharmacological treatments are effective for the management of hyperlipidemia, alternative approaches like dietary supplements are gaining interest for their natural benefits. The present study aimed to evaluate the safety and efficacy of biozen syrup comprised of garlic, apple-cider vinegar, lemon and honey for controlling patients with hyperlipidemia.

Methods

A prospective, open-label study was conducted on patients who had hyperlipidemia. Patients were given with biozen syrup (15 ml in 100 ml warm water) twice daily for 90 days. Clinical assessments and laboratory findings were compared before (day 0) and after (day 90) starting the treatment.

Results

A total of 60 patients were enrolled in the study. After administration of biozen syrup, serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high-sensitivity C-reactive protein (hs-CRP), homocysteine, and apolipoprotein B levels significantly decreased (p < 0.001). The mean serum apolipoprotein A1, high-density lipoprotein cholesterol (HDL-C) were raised post-treatment (p < 0.001). Treatment with biozen syrup had no significant effects (p > 0.001) on serum biochemical parameters related to liver, kidney functions and hematological parameters. Gastrointestinal disturbances was the most frequently occurred ADR (58 %).

Conclusion

The results demonstrated that the biozen was safe and efficacious in lowering the levels of bad cholesterol and raising the levels of good cholesterol.

背景：高脂血症的日益流行已成为公众健康的最大威胁之一。虽然药物治疗对高脂血症的治疗是有效的，但像膳食补充剂这样的替代方法因其天然的益处而受到关注。本研究旨在评价由大蒜、苹果醋、柠檬和蜂蜜组成的biozen糖浆控制高脂血症患者的安全性和有效性。方法对高脂血症患者进行前瞻性、开放标签研究。患者每日2次给予biozen糖浆（15 ml放入100 ml温水中），连续90天。比较治疗开始前（第0天）和治疗开始后（第90天）的临床评估和实验室结果。结果共纳入60例患者。给药后，血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）、高敏c反应蛋白（hs-CRP）、同型半胱氨酸和载脂蛋白B水平显著降低(p <；0.001)。治疗后血清载脂蛋白A1、高密度脂蛋白胆固醇（HDL-C）均升高(p <；0.001)。用生化糖浆治疗无显著效果(p >；0.001)对肝肾功能相关生化指标和血液学指标的影响。胃肠道紊乱是最常见的不良反应（58%）。结论该制剂具有降低坏胆固醇、提高好胆固醇的作用，安全有效。

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引用次数: 0

Assessing the relationship between demographic characteristics, lifestyle factors, and obesity metrics among adults in Haiphong, Vietnam 评估越南海防市成年人人口特征、生活方式因素和肥胖指标之间的关系

Q2 Medicine

Obesity Medicine

Pub Date : 2025-03-18 DOI: 10.1016/j.obmed.2025.100600

Duc Minh Cap , Kien Trung Dong , Diem Thi Hong Nguyen , Hong Thi Nguyen , Khoa Xuan Tang , Anh Hai Cao , Linh Thuy Nguyen , Tuyet Thi Hong Nguyen , Minh Duc Pham

Aims

This study aimed to assess the association between demographic characteristics, lifestyle factors, and obesity metrics among adults in Haiphong, Vietnam.

Materials and methods

A community-based cross-sectional study involving 2100 participants was conducted using a multi-stage sampling technique. Data were collected through face-to-face interviews and anthropometric measurements. Overweight/obesity was defined using body mass index (BMI), whereas abdominal obesity was determined by waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). The association between demographic characteristics, lifestyle factors, and obesity metrics was assessed using univariable and multivariable logistic regression.

Results

The prevalence of overweight/obesity was 18.4 % (male, 22 %; female, 16.2 %). The rates of abdominal obesity based on the WC, WHR, and WHtR were 19.3 %, 54.0 %, and 41.1 %, respectively. There was a significant difference in the prevalence of overweight/obesity and abdominal obesity between genders. Males had higher rates of overweight/obesity and abdominal obesity based on WHtR, whereas females showed higher rates of abdominal obesity based on WC and WHR. Male sex, age, education, occupation, and sedentary time were significantly associated with being overweight/obese. Female sex, age, education, residence, alcohol dependence, sedentary time, and physical activity were significantly associated with at least one abdominal obesity indicator.

Conclusion

The prevalence of overweight/obesity and abdominal obesity in adults was high. Both demographic factors and unhealthy lifestyle habits were associated with overweight/obesity and abdominal obesity. This suggests the need for intervention strategies to modify lifestyle behaviors tailored to each age group and gender.

目的本研究旨在评估越南海防市成年人的人口统计学特征、生活方式因素和肥胖指标之间的关系。材料与方法采用多阶段抽样技术对2100名参与者进行了基于社区的横断面研究。通过面对面访谈和人体测量收集数据。超重/肥胖使用体重指数（BMI）来定义，而腹部肥胖由腰围（WC）、腰臀比（WHR）和腰高比（WHtR）来确定。使用单变量和多变量logistic回归评估人口统计学特征、生活方式因素和肥胖指标之间的关系。结果超重/肥胖患病率为18.4%(男性22%；女性，16.2%)。基于腰围、腰臀比和腰臀比的腹部肥胖率分别为19.3%、54.0%和41.1%。超重/肥胖和腹部肥胖的患病率在性别之间存在显著差异。基于腰臀比的男性超重/肥胖和腹部肥胖的比例更高，而基于腰围和腰臀比的女性腹部肥胖的比例更高。男性的性别、年龄、教育程度、职业和久坐时间与超重/肥胖显著相关。女性性别、年龄、教育程度、居住地、酒精依赖、久坐时间和体力活动与至少一项腹部肥胖指标显著相关。结论成人超重/肥胖和腹部肥胖患病率较高。人口因素和不健康的生活习惯都与超重/肥胖和腹部肥胖有关。这表明需要针对每个年龄组和性别制定干预策略来改变生活方式行为。

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引用次数: 0

Effect of 52-week liraglutide treatment on diabetes risk and glycaemic control in women with obesity and prior gestational diabetes. A randomized, double-blind, placebo-controlled study 利拉鲁肽治疗52周对肥胖合并妊娠糖尿病妇女糖尿病风险及血糖控制的影响。一项随机、双盲、安慰剂对照的研究

Q2 Medicine

Obesity Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.obmed.2025.100596

Roosa Perämäki , Meri-Maija Ollila , Janne Hukkanen , Marja Vääräsmäki , Jukka Uotila , Saara Metso , Heidi Hakkarainen , Reeta Rintamäki , Eliisa Löyttyniemi , Heidi Immonen , Risto Kaaja

Aims

We investigated the effect of 52-week liraglutide treatment on the incidence of type 2 diabetes (T2D) compared with placebo treatment in women with obesity and previous gestational diabetes (pGDM) requiring medical treatment. As secondary outcomes, the prevalence of prediabetes and glycaemic control were investigated.

Methods

Women were randomized to once daily subcutaneous liraglutide 1.8 mg or placebo for 52 weeks. Oral glucose tolerance test, C-peptide, insulin, HbA1c and lipids were determined at baseline, 26 weeks, and 52 weeks.

Results

In total, 75 women [mean age of 34.5 years, median BMI of 38.0 kg/m²] were assigned to liraglutide (n = 37) or placebo (n = 38). At 52 weeks, T2D was diagnosed in 3% (n = 1) of the liraglutide group and 8% (n = 2) of the placebo group (p = 0.58), and prediabetes in 27% (n = 9) and 58% (n = 15), respectively (p = 0.032). In intention-to-treat analysis, 52-week liraglutide treatment reduced fasting glucose [group × time interaction p = 0.0047; estimated treatment difference (ETD) at 52 weeks −0.5 mmol/L, p = 0.0020], HbA1c [p = 0.020; ETD -0.2% (−2.1 mmol/mol), p = 0.056], weight (p = 0.0087; ETD -6.2 kg, p = 0.20) and waist circumference (p = 0.022; ETD -3.9 cm, p = 0.25), and improved Matsuda index (p = 0.049; ETD 0.7, p = 0.011) compared with placebo.

Conclusions

Liraglutide reduces the prevalence of prediabetes and improves glycaemic control in women with obesity and pGDM. Due to few T2D cases, the effect of liraglutide on diabetes risk could not be reliably assessed.

目的：研究利拉鲁肽治疗52周后，与安慰剂治疗相比，对需要药物治疗的肥胖和既往妊娠期糖尿病（pGDM）妇女2型糖尿病（T2D）发病率的影响。作为次要结局，研究了前驱糖尿病的患病率和血糖控制。方法随机选择每日1次皮下注射利拉鲁肽1.8 mg组或安慰剂组，连续52周。分别在基线、26周和52周检测口服糖耐量、c肽、胰岛素、糖化血红蛋白和血脂。结果共有75名女性[平均年龄34.5岁，中位BMI为38.0 kg/m2]被分配到利拉鲁肽组（n = 37）或安慰剂组（n = 38）。52周时，利拉鲁肽组中有3% （n = 1）和8% （n = 2）的患者被诊断为T2D (p = 0.58)，而前驱糖尿病患者分别为27% （n = 9）和58% (n = 15) （p = 0.032）。意向治疗分析中，52周利拉鲁肽治疗可降低空腹血糖[组×时间相互作用p = 0.0047；估计治疗差异（ETD）在52周- 0.5 mmol/L, p = 0.0020), HbA1c [p = 0.020；要领(−2.1更易与摩尔)-0.2%,p = 0.056),体重(p = 0.0087;ETD -6.2 kg, p = 0.20)和腰围(p = 0.022；ETD -3.9 cm, p = 0.25)，改善了Matsuda指数(p = 0.049；ETD为0.7,p = 0.011)。结论利拉鲁肽可降低糖尿病前期患者的患病率，改善肥胖和重度糖尿病女性的血糖控制。由于T2D病例较少，利拉鲁肽对糖尿病风险的影响不能可靠地评估。

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引用次数: 0

Survey on the herbal combinations in traditional Vietnamese medicine formulas for obesity treatment based on literature 基于文献的越南传统治疗肥胖方剂中草药组合调查

Q2 Medicine

Obesity Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.obmed.2025.100598

Duong Thi Huong Nguyen, Huy Khanh Tang, An Thi Hoai Nguyen, Luu Bao Le

Objectives

Today, obesity is a significant public health concern. Traditional medicine, known for its minimal side effects and positive outcomes, is increasingly being utilized as an alternative intervention in clinical practice. This study seeks to examine Vietnamese literature to identify herbs that can aid in reducing obesity and to interpret the association rules among these herbs.

Methods

Four hundred thirty-six formulas were collected from 43 documents suited to inclusion criteria. Using Microsoft Excel 2016, we continuously interpreted the characteristics of 320 herbs extracted from 436 anti-obesity formulas. The Apriori algorithm, operated by R Studio version 4.3.3, investigated the association rules among core materials.

Results

Shan Zha (Fructus crataegi) is the most popular herb mentioned in 436 compounded medications. The predominant property and flavor were warm (33,02%) and sweet (52,7%), respectively. Eventually, we also found 18 association rules and screened out 7 potential anti-obesity herbs. Each rule consists of two or three components. Especially, the greatest prevalent associated law is a triple combination among Fu Ling (Poria cocos), Ban Xia (Rhizoma pinelliae), and Chen Pi (Pericarpium citri reticulatae).

Conclusions

This study documents traditional Vietnamese medicinal knowledge on herbs with anti-obesity properties. According to the traditional function, all of herbs can be divided into these classifications: Tonify Spleen-Qi, Move Qi and invigorate Blood, Resolve retention of food, Resolve Dampness and Promoting diuresis. Besides, the pharmacological functions of them are suppressing appetite, inhibition of fat absorption and elevation of fat metabolism rate.

今天，肥胖是一个重要的公共健康问题。传统医学以其最小的副作用和积极的结果而闻名，越来越多地被用作临床实践中的替代干预措施。本研究旨在研究越南文献，以确定可以帮助减少肥胖的草药，并解释这些草药之间的关联规则。方法从43篇符合纳入标准的文献中抽取436个方剂。我们使用Microsoft Excel 2016对436种抗肥胖配方中提取的320种草药的特性进行了连续解析。使用R Studio 4.3.3版本运行的Apriori算法，研究核心材料之间的关联规则。结果山楂在436种复方药物中被提及最多。其主要特性和风味分别为温（33.02%）和甜（52.7%）。最终，我们还发现了18条关联规则，筛选出了7种潜在的抗肥胖草药。每个规则由两个或三个部分组成。尤以茯苓（茯苓）、半夏（半夏）、陈皮（柑桔皮）的三联系最为普遍。结论本研究记录了越南传统医药知识中具有抗肥胖作用的草药。根据传统的功能，所有的草药都可以分为以下几类：健脾、气血、解食、化湿、利尿。此外，其药理作用还包括抑制食欲、抑制脂肪吸收、提高脂肪代谢率等。

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引用次数: 0

The application of biohacking in obesity medicine: New perspectives on obesity's socioeconomic effects and disease mechanisms 生物黑客技术在肥胖症医学中的应用：肥胖症的社会经济影响和疾病机制新视角

Q2 Medicine

Obesity Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.obmed.2025.100586

Ammar Abdulrahman Jairoun

Obesity is a complex health issue that affects every nation worldwide. It is associated with various economic and societal difficulties, substantial comorbidities, and complex disease mechanisms. Conventional approaches to treating obesity often do not result in tailored, sustainable health outcomes. However, new approaches to its treatment may be found in biohacking, an approach defined by the combined use of technology, advances in science, and self-experimentation. This Editorial explores biohacking's potential role in managing obesity, particularly in addressing its behavioral factors, socioeconomic effects, and disease mechanisms. Biohacking aims to manipulate core biological processes such as gene expression, systemic inflammation, and cellular health to reduce the risks associated with obesity and enhance metabolic health. These techniques include nutrigenomics, microbiome manipulation, and intermittent fasting with wearable technologies and ongoing glucose monitors, allowing people to access their health data in real time and personalize their approach to managing their weight. With the support of habit-establishing strategies and mindfulness tools, behavioral interventions underpinned by biohacking principles can deliver long-term changes to people's lifestyles. Biohacking offers potential benefits not only for the individual but also for society, where it may lessen healthcare inequalities by providing low-cost, accessible tools. Nonetheless, ethical concerns about self-experimentation and biohacking's equitability and safety remain. However, integrating biohacking into conventional medicine could transform obesity management and tackle its many associated factors by delivering tailored, preventative treatment options.

肥胖是一个影响全世界每个国家的复杂健康问题。它与各种经济和社会困难、大量合并症和复杂的疾病机制有关。治疗肥胖的传统方法往往不能带来量身定制的、可持续的健康结果。然而，在生物黑客中可能会发现新的治疗方法，这是一种结合使用技术、科学进步和自我实验的方法。这篇社论探讨了生物黑客在控制肥胖方面的潜在作用，特别是在解决其行为因素、社会经济影响和疾病机制方面。生物黑客旨在操纵核心生物过程，如基因表达、全身炎症和细胞健康，以减少与肥胖相关的风险，增强代谢健康。这些技术包括营养基因组学、微生物组操纵和间歇性禁食，使用可穿戴技术和持续血糖监测仪，使人们能够实时访问他们的健康数据，并个性化他们的体重管理方法。在习惯养成策略和正念工具的支持下，以生物黑客原理为基础的行为干预可以为人们的生活方式带来长期的改变。生物黑客不仅为个人，也为社会提供了潜在的好处，它可以通过提供低成本、可获得的工具来减少医疗不平等。尽管如此，关于自我实验和生物黑客的公平性和安全性的伦理担忧仍然存在。然而，将生物黑客技术整合到传统医学中可能会改变肥胖管理，并通过提供量身定制的预防性治疗方案来解决其许多相关因素。

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引用次数: 0

Hypertension in obese and severely malnourished children in resource-limited countries: Preliminary results of a comparative cross-sectional study 资源有限国家肥胖和严重营养不良儿童的高血压：一项比较横断面研究的初步结果

Q2 Medicine

Obesity Medicine

Pub Date : 2025-03-01 DOI: 10.1016/j.obmed.2025.100594

Mudahama Francis Neema , Mongwa Justin Mbikilile , Archippe Muhandule Birindwa

Backgroung

Hypertension is one of the world's leading causes of death, and few studies have shown the impact of its frequency on malnourished and overweight children.

Objective

the objective of this study is to describe the frequency of hypertension in obese and malnourished children comparing two areas, urban and rural in the country with limited resources, preliminary results of the cross-sectional study.

Method

In this study, we describe the preliminary results of the cross-sectional study we conducted, including obese, malnourished children from selected rural and urban health centers dealing with eating disorders and nutrition in the eastern Democratic Republic of Congo (DRC).

Results

The frequency of arterial hypertension in obese, malnourished children of normal constitution was 37.8% in two zones, rural and urban, and the most represented age was over 10 years.

Conclusion

Hypertension in children is still an under-diagnosed condition, yet its frequency remains high, and even obese and malnourished children are not excluded. If primary health care facilities were equipped with the appropriate measures, early diagnosis would be possible.

背景高血压是世界上最主要的死亡原因之一，很少有研究显示高血压对营养不良和超重儿童的影响。本研究的目的是描述肥胖和营养不良儿童患高血压的频率，并对资源有限的国家的城市和农村两个地区进行比较，这是横断面研究的初步结果。方法在本研究中，我们介绍了横断面研究的初步结果，研究对象包括来自刚果民主共和国（DRC）东部选定的处理饮食失调和营养问题的农村和城市医疗中心的肥胖和营养不良儿童。结果在农村和城市两个地区，体质正常的肥胖、营养不良儿童中动脉高血压的发病率为 37.8%，发病年龄多在 10 岁以上。如果基层医疗机构配备了适当的措施，就有可能做到早期诊断。

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引用次数: 0

Healing wounds in diabetes: Exploring cutting-edge natural extracellular vesicle therapeutics 糖尿病伤口愈合：探索先进的天然细胞外囊泡疗法

Q2 Medicine

Obesity Medicine

Pub Date : 2025-02-21 DOI: 10.1016/j.obmed.2025.100597

Mumtaj Bano Miya , Pankaj Chaturvedi , Vandana Pathak , Prakash Chandra Gupta , Anuradha Kalani

Managing diabetes-related foot ulcers is challenging due to their slow healing process, peripheral neuropathy, reduced blood flow and increased risk of infection. Exploring alternative approaches, such as medicinal plant-based therapies, could provide promising solutions for diabetic wound healing. The current review discusses the therapeutic potential of different extracellular vesicles for diabetic wound healing. A newly developed oxygenated nanotherapeutic, OXY-Exo^Aloe, is further discussed, which is formulated by combining the medicinal potential of Aloe barbadensis, Azadirachta indica, and Zingiber officinale. The oxygenated nanotherapeutics could offer a multi-faceted approach to wound healing and may revolutionize advancements in nanotechnology and medicinal plant-based therapies for the treatment of diabetic foot ulcers in the future.

由于糖尿病相关足溃疡的愈合过程缓慢、周围神经病变、血流量减少和感染风险增加，管理糖尿病相关足溃疡具有挑战性。探索替代方法，如药用植物疗法，可能为糖尿病伤口愈合提供有希望的解决方案。本文综述了不同细胞外囊泡对糖尿病伤口愈合的治疗潜力。进一步讨论了一种新开发的氧合纳米治疗药物OXY-ExoAloe，该药物结合了芦荟，印楝和生姜的药用潜力。氧化纳米疗法可以为伤口愈合提供多方面的方法，并可能在纳米技术和药用植物治疗糖尿病足溃疡方面取得革命性的进展。

引用次数: 0

Association and inequality between socioeconomic status and the prevalence of overweight and obesity among adults aged 18 and older in Bangladesh 社会经济地位与孟加拉国18岁及以上成年人超重和肥胖流行率之间的关联和不平等

Q2 Medicine

Obesity Medicine

Pub Date : 2025-02-19 DOI: 10.1016/j.obmed.2025.100595

Sukanta Das

Background

Overweight and obesity have emerged as significant public health concerns in Bangladesh. This study aims to assess the association between socioeconomic status (SES) and the prevalence of overweight and obesity while identifying socioeconomic inequalities among adults aged 18 and older in Bangladesh.

Methods

Using data from the Bangladesh Demographic and Health Survey (BDHS) 2017–18, this study analyzed a sample of 24,478 adults. Overweight and obesity were classified according to the World Health Organization's Body Mass Index (BMI) guidelines. SES was measured by wealth index, and its association with overweight and obesity was examined using multivariate logistic regression analysis. Socioeconomic inequality was evaluated using concentration curves and indexes.

Results

The overall prevalence of overweight and obesity was 31.8% and 13.4%, respectively. Even after controlling for age, gender, education, and place of residence, higher socioeconomic status was significantly associated with an increased risk of being overweight or obese. Adults in the richest wealth category were 3.2 times more likely to be overweight and 9.8 times more likely to be obese compared to those in the poorest category (p < 0.01). The concentration index of 0.35 (CI: 0.33 to 0.37;

p

< 0.01) indicated that overweight and obesity were more prevalent among wealthier adults, highlighting a pro-rich inequality.

Conclusion

There is a significant socioeconomic disparity in the prevalence of overweight and obesity in Bangladesh, with wealthier adults disproportionately affected. Targeted public health initiatives are needed to curb this growing epidemic, particularly among wealthier groups, to reduce obesity-related non-communicable diseases.

背景超重和肥胖已成为孟加拉国重大的公共卫生问题。本研究旨在评估社会经济地位（SES）与超重和肥胖患病率之间的关系，同时确定孟加拉国18岁及以上成年人的社会经济不平等。方法利用2017-18年孟加拉国人口与健康调查（BDHS）的数据，本研究分析了24,478名成年人的样本。超重和肥胖是根据世界卫生组织的身体质量指数（BMI）指南进行分类的。以财富指数衡量社会经济地位，并采用多变量logistic回归分析检验其与超重和肥胖的关系。采用浓度曲线和指数评价社会经济不平等。结果超重和肥胖的总体患病率分别为31.8%和13.4%。即使在控制了年龄、性别、教育程度和居住地之后，较高的社会经济地位与超重或肥胖的风险增加显著相关。最富有人群超重的可能性是最贫穷人群的3.2倍，肥胖的可能性是最贫穷人群的9.8倍(p <；0.01)。浓度指数为0.35 (CI: 0.33 ~ 0.37；p & lt;0.01)表明，超重和肥胖在富裕的成年人中更为普遍，凸显了亲富的不平等。结论：在孟加拉国，超重和肥胖的患病率存在显著的社会经济差异，富裕的成年人受到的影响尤为严重。需要采取有针对性的公共卫生举措，遏制这一日益严重的流行病，特别是在较富裕群体中，以减少与肥胖有关的非传染性疾病。

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引用次数: 0

Correlation between estimated glucose disposal rate, carotid intima-media thickness and cardiovascular risk prediction scales in adolescents and young adults with type 1 diabetes 青少年和青年1型糖尿病患者估计葡萄糖处置率、颈动脉内膜-中膜厚度和心血管风险预测量表的相关性

Q2 Medicine

Obesity Medicine

Pub Date : 2025-02-18 DOI: 10.1016/j.obmed.2025.100592

David Sánchez-García, Eloísa Saavedra-Castillo, Mariela Rivas-Hernández, Luis Diego Maximiliano Ramos-Anthony, Graciela Gómez-Martínez, Marcelo Diaz-Sallas, Dania Lizet Quintanilla-Flores

Aims

To analyze the correlation between estimated glucose disposal rate (eGDR), Carotid intima-media thickness (CIMT) and cardiovascular risk prediction scales in young adults with diabetes type 1 (T1D).

Methods

A cross-sectional, analytical, and retrospective study was conducted. Patients with T1D > 15 years were included, insulin resistance (IR) was defined by eGDR <8 mg/kg/min, and preclinical atherosclerosis as ≥0.54 mm of CIMT, STENO and ESC cardiovascular risk was calculated. Pearson's correlation test was used to measure the strength of association between them.

Results

102 patients with a median age of 19 years, HbA1c of 8.2%, diabetes duration of 8 years were included. IR was found in 50.9% of the patients and preclinical atherosclerosis in 46.1%, with a median CIMT of 0.52 mm. An inverse correlation was obtained between the eGDR and CIMT r = −0.23, p = 0.021, and STENO r = 0.33, p=<0.001, CIMT was higher in the IR group 0.54 vs 0.50 mm, p = 0.047, also was associated with more microvascular complications 36.5% vs 18%, p = 0.03, and proinflammatory markers, p=<0.001.

Conclusions

Carotid intima-media thickening is inversely associated with insulin sensitivity, the eGDR value could be used as a cardiovascular and as a enhance risk factor and could help to decide treatment in patients whit T1D.

目的分析1型糖尿病（T1D）青年患者估计葡萄糖处置率（eGDR）、颈动脉内膜-中膜厚度（CIMT）与心血管风险预测量表的相关性。方法采用横断面、分析和回顾性研究。T1D >患者；纳入15年，胰岛素抵抗（IR）定义为eGDR <；8 mg/kg/min，临床前动脉粥样硬化≥0.54 mm的CIMT，计算STENO和ESC心血管风险。使用Pearson相关检验来衡量两者之间的关联强度。结果纳入102例患者，中位年龄19岁，HbA1c为8.2%，糖尿病病程8年。50.9%的患者发现IR， 46.1%的患者发现临床前动脉粥样硬化，中位CIMT为0.52 mm。eGDR与CIMT r = - 0.23, p= 0.021, STENO r = 0.33, p=<；0.001呈负相关，IR组CIMT较高（0.54 vs 0.50 mm, p= 0.047），微血管并发症发生率较高（36.5% vs 18%, p= 0.03），促炎标志物发生率较高（p=<0.001）。结论颈动脉内膜-中膜增厚与胰岛素敏感性呈负相关，eGDR值可作为T1D患者的心血管和增强危险因素，有助于决定治疗方案。

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引用次数: 0