Schizophrenia Research-Cognition最新文献

{"title":"Equivalence verification of the electronic version of the Chinese Brief Cognitive Test (C-BCT): Focus on Chinese schizophrenia populations","authors":"Han Han ,&nbsp;Shuling Ye ,&nbsp;Mengjuan Xie ,&nbsp;Xin Yu ,&nbsp;Renrong Wu ,&nbsp;Dengtang Liu ,&nbsp;Shaohua Hu ,&nbsp;Yong Xu ,&nbsp;Huanzhong Liu ,&nbsp;Xijin Wang ,&nbsp;Gang Zhu ,&nbsp;Huaning Wang ,&nbsp;Shaohong Zou ,&nbsp;Tao Li ,&nbsp;Wanjun Guo ,&nbsp;Xiufeng Xu ,&nbsp;Yuqi Cheng ,&nbsp;Yi Li ,&nbsp;Juan Yang ,&nbsp;Min Peng ,&nbsp;Chuan Shi","doi":"10.1016/j.scog.2025.100386","DOIUrl":"10.1016/j.scog.2025.100386","url":null,"abstract":"<div><h3>Objective</h3><div>To complete the preparation of the electronic version of C-BCT, verifying the criterion validity of the electronic version of C-BCT.</div></div><div><h3>Methods</h3><div>747 healthy subjects and 139 schizophrenics completed the electronic version of C-BCT and MCCB. To measure psychotic symptoms and severity, patients with schizophrenia completed the PANSS scale. Mean, standard deviation, percentage, etc. were used to describe demographic variables. One-way analysis of variance and independent sample <em>t-</em>test were used to compare differences between groups. MCCB as a calibration tool, criterion validity was examined using Pearson product moment correlations.</div></div><div><h3>Results</h3><div>In the equivalence analysis of the healthy group, all tests have good calibration validity (<em>p</em> &lt; 0.01). SC and TMT-A showed moderate correlation (r- value ranged from 0.572 to 0.651, <em>p</em> &lt; 0.01), DS showed a weak correlation(<em>r</em> = 0.373, <em>p</em> &lt; 0.01), CPT showed a weak correlation (r- value ranged from 0.219 to 0.444, <em>p</em> &lt; 0.01), the comprehensive scores of the two sets of cognitive tools showed a strong correlation (<em>r</em> = 0.739, p &lt; 0.01). In the equivalence analysis of the patient group, TMT-A and SC showed strong correlation (r- value ranged from 0.754 to 0.803, p &lt; 0.01), DS showed a weak correlation (<em>r</em> = 0.381, <em>p</em> &lt; 0.01), the cognitive tools comprehensive score was significantly strong correlation (<em>r</em> = 0.755, p &lt; 0.01), there was no correlation between CPT(<em>p</em> &gt; 0.05). In the healthy group, there was a correlation between the scores of each subtest of the electronic version of C-BCT and the comprehensive scores of the two cognition tools, (r- value ranged from 0.261 to 0.824, <em>p</em> &lt; 0.01). In the patient group, there was a correlation between the scores of each subtest and the comprehensive scores of the two tools,(r- value ranged from 0.266 to 0.778, p &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>The electronic version of C-BCT has been compiled. The electronic version of the C-BCT performs well in overall calibration validity and could be used to assess the cognitive function of schizophrenia.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100386"},"PeriodicalIF":3.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous self-experience in schizophrenia spectrum disorders: Phenomenological and psychopathological correlates","authors":"Alessio Mosca ,&nbsp;Stefania Chiappini ,&nbsp;Arianna Pasino ,&nbsp;Andrea Miuli ,&nbsp;Carlotta Marrangone ,&nbsp;Mauro Pettorruso ,&nbsp;Giovanni Martinotti","doi":"10.1016/j.scog.2025.100389","DOIUrl":"10.1016/j.scog.2025.100389","url":null,"abstract":"<div><h3>Background</h3><div>Anomalous self-experiences (ASEs) are increasingly recognized as core features of schizophrenia spectrum disorders, reflecting disruptions of the pre-reflective self or <em>ipseity</em>. While ASEs have been conceptualized as foundational to psychotic vulnerability, their empirical associations with broader clinical and psychological dimensions remain underexplored.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the relationship between ASEs, schizotypal traits, general psychopathology, personality dimensions, and intolerance of uncertainty in individuals diagnosed with schizophrenia-spectrum disorders.</div></div><div><h3>Methods</h3><div>A cross-sectional sample of clinically stable patients (<em>n</em> = 30) with schizophrenia-spectrum disorders was assessed using the Examination of Anomalous Self-Experience (EASE), Positive and Negative Syndrome Scale (PANSS), Schizotypal Personality Questionnaire (SPQ), Big Five Questionnaire (BFQ), and the Intolerance of Uncertainty Scale. Pearson correlations and multiple linear regression analyses were performed to examine associations and predictive factors of self-disturbance severity.</div></div><div><h3>Results</h3><div>EASE scores were significantly correlated with SPQ total and cognitive-perceptual dimensions, general psychopathology (PANSS), and intolerance of uncertainty. Regression analysis identified SPQ total positive percentage, PANSS general psychopathology scores, and prospective intolerance of uncertainty as significantly associated with ASEs, explaining 42 % of the total variance. BFQ personality traits showed no significant predictive value.</div></div><div><h3>Conclusion</h3><div>These findings support the conceptualization of ASEs as a core, trait-like feature of schizophrenia-spectrum psychopathology. The study highlights the interconnection between self-disturbance and schizotypy, affective dysregulation, and experiential disorganization. Incorporating phenomenological assessment into routine clinical practice may enhance early detection and inform targeted therapeutic approaches.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100389"},"PeriodicalIF":3.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition before and after psychosis onset: A naturalistic study of change, heterogeneity, and prognosis","authors":"Maria Lee ,&nbsp;Alexis E. Cullen ,&nbsp;Granville J. Matheson ,&nbsp;Zheng-An Lu ,&nbsp;Sarah E. Bergen ,&nbsp;Carl M. Sellgren ,&nbsp;Sophie Erhardt ,&nbsp;Helena Fatouros-Bergman ,&nbsp;Simon Cervenka","doi":"10.1016/j.scog.2025.100387","DOIUrl":"10.1016/j.scog.2025.100387","url":null,"abstract":"<div><h3>Aims</h3><div>Cognitive dysfunction is a core feature of psychotic disorders. The degree of impairment varies greatly between individuals, which may reflect different levels of decline from pre-morbid functioning. Diverse trajectories of cognitive change prior to or during development of psychosis have been hypothesized to reflect distinct underlying pathological processes. Our primary aim was to model cognitive change over time in a sample of individuals with first-episode psychosis (FEP) and controls. The secondary aim was to explore associations between cognitive change, clinical outcomes and select biological markers.</div></div><div><h3>Methods</h3><div>Our sample consisted of 72 individuals with FEP and 53 controls. School grades from nationwide population registers were used as a proxy for pre-morbid cognitive ability. All participants underwent formal cognitive testing at psychosis onset, with a subset returning for testing at 1,5 year follow up. Cognitive change was modelled using linear mixed-effects models, and resulting change scores were correlated to polygenic risk scores, cerebrospinal fluid levels of complement protein C4A and clinical outcomes.</div></div><div><h3>Results</h3><div>Groups did not differ in school performance prior to psychosis. Psychosis onset was associated with marked cognitive decline in FEP individuals, who subsequently performed significantly worse than controls. However, cognitive change over time varied widely between FEP individuals. Degree of cognitive change was not associated with the selected biological variables but did predict worse clinical outcomes.</div></div><div><h3>Conclusions</h3><div>Individual cognitive trajectories may be a clinically relevant topic for further study, and larger studies are needed to further explore their potential role in stratified models of care.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100387"},"PeriodicalIF":3.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom severity and cognitive performance in patients with substance induced psychotic disorder and schizophrenia: a cross-sectional comparative study","authors":"Kaloyan Stoychev ,&nbsp;Ivanka Veleva ,&nbsp;Eleonora Mineva-Dimitrova ,&nbsp;Petranka Chumpalova ,&nbsp;Emiliya Dimitrova","doi":"10.1016/j.scog.2025.100388","DOIUrl":"10.1016/j.scog.2025.100388","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>psychotic disorders induced by substances like marijuana, amphetamines and methamphetamines (SIPDs) are a growing mental health problem, yet the question do they represent a separate psychotic class independent from schizophrenia (SZ) still stands. Studies comparing clinical and cognitive performance of SIPD and SZ patients have produced inconsistent results.</div></div><div><h3>Study design</h3><div>we performed a cross-sectional analysis of 62 subjects divided into two statistically matched groups (<em>n</em> = 31 each) with SZ and SIPD respectively. We compared the clinical severity of their symptoms as measured by the positive and negative PANSS scores. We then applied the following neurocognitive battery – 10 Words Memory Test of Luria for verbal learning and verbal memory; Digit Symbol Substitution Test (DSST) and Benton Visual Retention Test for processing speed and visual memory; Trail Making Test Part A &amp; B for attention and cognitive flexibility (along with DSST); Logical Memory Test (LMT) for episodic memory and thinking disorders; Verbal Fluency Test (VFT) for semantic memory and language. We referenced the performance results of the two groups to the normative values of each of the tests.</div></div><div><h3>Study results</h3><div>SZ subjects had significantly higher positive and negative PANSS scores and greater impairment in all cognitive domains except semantic memory and language (VFT). Compared to the normative values of all tests both SZ and SIPD patients performed poorer.</div></div><div><h3>Conclusions</h3><div>Our data support the assumption that the two conditions share a common underlying neurobiological vulnerability that is more pronounced quantitatively in schizophrenia.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100388"},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationships between Early Childhood Adversity, Social Cognition, and Aggression in a South African Study of People Living with Schizophrenia","authors":"K. van der Walt ,&nbsp;O. Wootton ,&nbsp;J. Rokicki ,&nbsp;A. Vaskinn ,&nbsp;D. Jonker ,&nbsp;M. Campbell ,&nbsp;E. Susser ,&nbsp;U.K. Haukvik ,&nbsp;R.C. Gur ,&nbsp;D.J. Stein ,&nbsp;C. Friestad","doi":"10.1016/j.scog.2025.100382","DOIUrl":"10.1016/j.scog.2025.100382","url":null,"abstract":"<div><div>People living with schizophrenia (PLS) are at increased risk of being both victims and perpetrators of violence. Recent research suggests that social cognitive impairments may contribute to heightened aggression in schizophrenia. Childhood trauma, a well-established risk factor for both schizophrenia and aggression, is also linked to more severe cognitive deficits in PLS. Few studies have explored the relationships between childhood trauma, social cognition, and aggression in large sample sizes, particularly in low- and middle-income settings, where varying socioeconomic factors and exposure to violence may influence these associations. In this study, a subsample of participants (PLS = 585; controls = 882) from the <em>Genomics of Schizophrenia in the South African Xhosa People</em> study completed The Childhood Trauma Questionnaire (CTQ), Penn Emotion Identification Test (ER), Life History of Aggression Questionnaire (LHA), and Structured Diagnostic Interview for DSM-IV Axis I Disorders. Group differences in CTQ, ER, LHA, and selected demographic and clinical factors were assessed using <em>t</em>-tests and chi-square tests. Multivariable linear regressions were employed to test for associations among CTQ, ER, and LHA. We found that PLS had significantly higher childhood trauma and lifetime aggression scores and poorer emotion recognition performance than controls. Higher childhood trauma was associated with higher lifetime aggression and worse emotion recognition performance. However, emotion recognition performance was not associated with lifetime aggression. In this setting, childhood trauma predicts lifetime aggression and poorer emotion recognition, but there is no evidence that emotion recognition ability is related to aggression.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100382"},"PeriodicalIF":3.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring theory of mind abilities in Lebanese chronic patients with schizophrenia: A cross-sectional study","authors":"Marie Ghosn ,&nbsp;Chadia Haddad ,&nbsp;Jean-Marc Rabil ,&nbsp;Georges Haddad","doi":"10.1016/j.scog.2025.100385","DOIUrl":"10.1016/j.scog.2025.100385","url":null,"abstract":"<div><h3>Introduction</h3><div>In recent decades, social cognition has become a central focus in schizophrenia research. Multiple previous studies reported impairments in multiple social cognitive domains. One particular domain of social cognition affected in schizophrenia is “Theory of Mind (TOM). The objective of this study was to examine the heterogeneity of ToM impairments within the schizophrenia population and compare TOM performance between individuals diagnosed with schizophrenia and a matched healthy control group.</div></div><div><h3>Methods</h3><div>a cross-sectional study was conducted between June 2024 and September 2024 at the Psychiatric Hospital of the Cross (HPC) in Lebanon that explored TOM abilities in 146, chronic Lebanese schizophrenia inpatients and 50 healthy controls, using the Arabic translation of the “TOM-15,” a False Belief Task.</div></div><div><h3>Results</h3><div>A significant difference between schizophrenia patients and healthy controls was found, with the patient group scoring poorer on both first-order, and second-order false belief and in the comprehension control task of the TOM-15. Furthermore, among the patient population, impairments in second-order false belief were more pronounced than first-order. Performance on the BACS scale for neuro-cognition showed moderate associations with performance on the TOM-15. Multivariable analysis revealed a negative association between depression and second-order tasks as well as females outperforming males in TOM-15, especially in the second-order task.</div></div><div><h3>Conclusion</h3><div>The results revealed significant TOM impairments in patients with schizophrenia as compared to healthy controls, with greater difficulties observed in second-order false belief tasks.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100385"},"PeriodicalIF":3.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wide Range Achievement Test word reading subtest score as an indicator of premorbid intellectual disability in serious mental illness","authors":"Susan R. McGurk ,&nbsp;Renata Botello ,&nbsp;Daniel Fulford ,&nbsp;Kim T. Mueser","doi":"10.1016/j.scog.2025.100381","DOIUrl":"10.1016/j.scog.2025.100381","url":null,"abstract":"<div><h3>Objective</h3><div>Performance on reading tests is often used as an indicator of premorbid intellectual disability in individuals with serious mental illness (SMI), but independent evidence validating their use is lacking. This study evaluated the accuracy of the Wide Range Achievement Test Word Reading Subtest in predicting history of intellectual disability in people with SMI.</div></div><div><h3>Methods</h3><div>Participants were 105 people with SMI (62.8 % schizophrenia) with either a confirmed history of intellectual disability based on medical record review (Confirmed ID; <em>n</em> = 18) or no such history (No ID; <em>n</em> = 87). Participants were administered the WRAT-III Reading Subtest, the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery, and three other cognitive tests. A receiver operator characteristics (ROC) curve was fit to identify the optimal cutoff score on the WRAT for correctly classifying the Confirmed ID and No ID groups. <em>t</em>-tests and effect sizes were used to compare the two groups on the WRAT and cognitive tests.</div></div><div><h3>Results</h3><div>The ROC curve indicated that a cutoff score of 70 or below on the WRAT correctly identified 88.9 % of individuals with Confirmed ID (sensitivity) and incorrectly identified 5.6 % of individuals with No ID (Specificity) (<em>p</em> &lt; .001). Performance on the cognitive battery was worse in the Confirmed ID group than No ID group, but the effect size for the WRAT was higher than any of the cognitive tests.</div></div><div><h3>Conclusions</h3><div>A WRAT Word Reading Subtest score of ≤70 is a strong indicator of premorbid intellectual disability in people with SMI.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100381"},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and administration of the flexible adapted cognitive test battery for schizophrenia (FACTS)","authors":"Bing Cai ,&nbsp;William S. Stone ,&nbsp;Xinyi Ouyang ,&nbsp;Fei Deng ,&nbsp;Hanhui Chen ,&nbsp;Min Qian ,&nbsp;Margaux M. Grivel ,&nbsp;Matcheri S. Keshavan ,&nbsp;Ezra S. Susser ,&nbsp;Lawrence H. Yang ,&nbsp;Michael R. Phillips","doi":"10.1016/j.scog.2025.100377","DOIUrl":"10.1016/j.scog.2025.100377","url":null,"abstract":"<div><h3>Background</h3><div>Age and educational eligibility criteria for administration of the most widely used cognitive battery for schizophrenia typically exclude 20 % of individuals with schizophrenia in high-income countries and 25–50 % in middle- and low-income countries.</div></div><div><h3>Methods</h3><div>We developed the Flexible Adapted Cognitive Test battery for Schizophrenia (FACTS) that can be administered to <em>all</em> individuals with schizophrenia, regardless of age or education. To evaluate the utility and validity of the nine tests in the FACTS, two process measures are assessed during the administration of each test: ‘test comprehension’ and ‘test completion’ (successful or unsuccessful). The FACTS was administered to 495 community-dwelling individuals with schizophrenia and 308 healthy controls, including 473 (58.9 %) older or undereducated individuals typically excluded from studies of cognition in schizophrenia. Inter-rater reliability of the test comprehension and completion measures was assessed.</div></div><div><h3>Findings</h3><div>Older, undereducated participants successfully completed 82 % (3499/4257) of the administered tests. The mean weighted Kappa value for the nine test comprehension measures was 0.90 (range: 0.82–0.96), and the mean unweighted Kappa for the 20 test and subtest completion measures was 0.94 (range: 0.85–1.00).</div></div><div><h3>Interpretation</h3><div>Cognitive functioning is a core symptom cluster of schizophrenia, so the comprehensive assessment of cognitive functioning must become a standard part of the assessment of <em>all</em> individuals with schizophrenia, regardless of age or education. The development of the FACTS, which can be successfully administered to most older, undereducated individuals with schizophrenia, provides a model for doing this.</div></div><div><h3>Funding</h3><div>This study was supported by National Institute of Mental Health grants MH108385-R01 and MH127631-R01.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100377"},"PeriodicalIF":3.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The aperiodic and periodic activities of EEG dynamically relate with cognitive performance in schizophrenia","authors":"Kexin Zhang ,&nbsp;Yunfei Ji ,&nbsp;Xiaodong Guo ,&nbsp;Tianqi Gao ,&nbsp;Xuemin Zhang ,&nbsp;Xin Yu ,&nbsp;Jing Wang","doi":"10.1016/j.scog.2025.100383","DOIUrl":"10.1016/j.scog.2025.100383","url":null,"abstract":"<div><h3>Background</h3><div>Aperiodic and periodic activities of electrophysiological signals have strong correlation with various neurocognitive factors. In the current study, we aim to investigate the aperiodic exponent and periodic oscillations (alpha and beta band power) and their associations with cognitive performance in schizophrenia (SCZ).</div></div><div><h3>Methods</h3><div>We enrolled 32 SCZ patients and 33 healthy controls (HC) for the study. Cognitive performance was assessed using the total Brief Assessment of Cognition in Schizophrenia (BACS). Before and after the language comprehension tasks (humor, metaphor and irony), the 5-min eyes-closed and eyes-open EEG signals were collected respectively. The aperiodic exponent and periodic power were extracted and obtained according to the division of brain regions. Finally, Pearson correlation was used to examine the relationships between the EEG parameters and behavioral measures.</div></div><div><h3>Results</h3><div>SCZ participants exhibited higher aperiodic exponents and lower periodic oscillations compared to HC. The aperiodic exponent decreased significantly after the tasks in central location (<em>F</em> (56,1) = 8.93, <em>P</em> = 0.004, <em>η</em>² = 0.14) in both groups, while the periodic oscillations had no significant change. The variance of the aperiodic exponent showed significantly negative correlation with <em>Z</em> scores of humor comprehension tasks (<em>r</em> = −0.42, <em>P</em> = 0.027) in SCZ. Besides, the pre-tasks aperiodic exponent in posterior location positively correlated with <em>T</em> scores of attention and speed of information processing (<em>r</em> = 0.35, <em>P</em> = 0.048).</div></div><div><h3>Conclusions</h3><div>Our findings confirmed the higher aperiodic exponent with lower alpha and beta band in SCZ, along with the variability and task-responsiveness of the aperiodic exponent. The findings suggest that aperiodic exponent holds strong cognitive functional implications in SCZ.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100383"},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theory-of-mind improvement in schizophrenia after integrative cognitive remediation: which patients benefit more?","authors":"Agurne Sampedro ,&nbsp;Javier Peña ,&nbsp;Pedro Sánchez ,&nbsp;Naroa Ibarretxe-Bilbao ,&nbsp;Nagore Iriarte-Yoller ,&nbsp;Cristóbal Pavón ,&nbsp;Natalia Ojeda","doi":"10.1016/j.scog.2025.100380","DOIUrl":"10.1016/j.scog.2025.100380","url":null,"abstract":"<div><div>Social cognition, and specifically theory of mind, is considered a key factor in predicting functional outcomes and quality of life in schizophrenia. Although cognitive remediation is an effective intervention for improving theory of mind, little is known about the factors that moderate this improvement. Therefore, the aim of this study is to identify moderators of theory-of-mind improvement in schizophrenia after integrative cognitive remediation (REHACOP). Data from two randomized controlled trials were used in this secondary analysis. The sample included 182 patients (experimental group = 94; active control group = 88) from the Mental Health Network in Álava (Spain). A comprehensive assessment of clinical symptoms, neurocognition, theory of mind, and functional outcome at baseline and follow-up was carried out. Hierarchical regression analyses were used to identify moderators of theory-of-mind improvement. Regardless of the patients' initial profiles, the REHACOP was effective in improving theory of mind (<em>F</em> = 27.00, <em>p</em> &lt; .001). Regression analyses, however, revealed that baseline neurocognition (<em>β</em> = −0.223, <em>t</em> = −2.075, <em>p</em> = .039), baseline theory of mind (<em>β</em> = −0.325, <em>t</em> = −3.100, <em>p</em> = .002), and baseline positive symptoms (<em>β</em> = −0.243, <em>t</em> = −2.296, <em>p</em> = .023) played a moderating role in the improvement of theory of mind after the REHACOP. Results showed that those participants with lower baseline neurocognition and theory-of-mind scores and less positive symptoms obtained greater theory-of-mind benefits. Determining the factors that account for the different patterns of improvement after cognitive remediation could be helpful in the implementation of personalized cognitive remediation plans and for the appropriate use of healthcare resources.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"42 ","pages":"Article 100380"},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}